(CDKN1A) cyclin-dependent kinase inhibitor 1A (p21, Cip1) [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  4058
 Official symbol  CDKN1A
 Official name  cyclin-dependent kinase inhibitor 1A (p21, Cip1)
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 6 (NC_000006.11) :  36646458...36655108  (+)
 Map  6p21.1
 Length  8651  nt
Run another request
Search gene by
Query

Alternative name(s) and Synynom(s) top
Synonyms MDA-6; WAF1; SDI1; p21Cip1/Waf1; p21CIP1; P21; CIP1; CDKN1; CAP20
Alternative name(s) p21Cip1/Waf1; DNA synthesis inhibitor; wild-type p53-activated fragment 1; CDK-interaction protein 1; melanoma differentiation associated protein 6
External Links top
Ensembl ENSG00000124762
Entrez 1026
HGNC 1784
HPRD 00298
Comment top
Summary This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq].
Bibliography top
Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
1  TGTATATCAG GGCCGCGCTG AGCTGCGCCA GCTGAGGTGT GAGCAGCTGC CGAAGTCAGT TCCTTGTGGA GCCGGAGCTG
81  GGCGCGGATT CGCCGAGGCA CCGAGGCACT CAGAGGAGGT GAGAGAGCGG CGGCAGACAA CAGGGGACCC CGGGCCGGCG
161  GCCCAGAGCC GAGCCAAGCG TGCCCGCGTG TGTCCCTGCG TGTCCGCGAG GATGCGTGTT CGCGGGTGTG TGCTGCGTTC
241  ACAGGTGTTT CTGCGGCAGG TGAATGACGG GCGTGGGTCG GTGCGCGCTC GGCTTGCGCA CACGGTGTCT CTAAGTGCGC
321  GGGTGACGAG AGTCGGGATG TGCCGGAGAC CCCGGGGCGG AGAGCGGGAT TACAAGTACA GGAATCCCTG GTCACGCTCC
401  CCGCCCCTGG AAACCCAGCT GGGGCGAGGG AGGGCGTGGA CGGGACCGTT CTGGGAGCTC GCCTTTGGCT GCGGTTGGCT
481  CCAGGCCCCA GGCGCAGTTT GCTCGCGGCG TGGGGATGAA GTCCGTGTCC CTGGAGGGGC CCAGGAAGGG CGAGGAAAGC
561  GGAGTGGAGT AAGTTCGTCT AGGATCGGTC CCGGGTGGCT CTGGGATCCA ATCTGCGCCG CCCTGGCCCA GGTCCCAGGT
641  TCAGGTCCTT TACGCCACTG TGTCCACCAC CTGGCTGAGC GCTGAGGTCA GCGCGGGCTG TTTCCTGGCC CTTGGGAATG
721  TGCCAGGACC CGTCCCCTAA GGACTAGCGA GGAGGTGACT CACTGTGACA AGGAGACCCC AGGGAACGGA CTGTATGAGG
801  TCAGAACCCC GCCCGGGATG GGGTACAGCG GGACTCCAGA AGCCCTCTCC CCTGCCCCTT CGCGGTCTCC GTCCTCCCAT
881  CGGCACAGTG ACCTATTTGG CTGGAACAGT TTGTTCCCAA GGAAGCCGGG CACTGGAGGT CCGGGACACC GCGTCGGGTC
961  CCCGCTCCGC GGCGCGCTGT AGGGGTCGGG GAGTCACGGC CCTGCTCTGG GCGGGCTCTA ACCAGCCTGT CAGTCGGGGA
1041  AGGGCAAGGG TCTCCTCTAC CTCTTTCCCA CCGCGGCCGG GAGAATCGCG GCCCAGCCTG TCCTCGGGTC GGGGCGCTGG
1121  ACTCCGGGGC GGGAGCGGAG CCCACGCCTG GATGGGAGGC GGGGAGGGTT CATGTCTTTG AGGGGTGGGG GGTCTGGGGG
1201  GCACGACGCT GCTCAGGGCC TCTATCAGCT GCCTCGGGGG CTCAGGGCTT CCCGACCTAG CCCAGATTCC CTCTCCGAAA
1281  GCTACAGGGC TGAGCGGAGC AGGGGGGCGA GTCGCCCCCT GGGGCGCCGC CGCCTGGCGC GGACCACAGC GCGTCCTCTC
1361  CGTCCCAAAC CCCTGGGGGA CACTTGCGCC CTCTTCGTGA GGAAAAGCAT CTTGGAGCTG GGTTAGGAAC TTGGGGCGCC
1441  CAGGCAGCTT CCCCTCTCCT TGCCTCCCTC CACGTCGCGT TTCTGGGAGG ACTTGCGAGC GGTTTTGTTT TCGTTGCTCC
1521  CGTCTATTTT TATTTTCCAG GGATCTGACT CATCCCGTGC TTTGGGCGTG GAGATAAGGT GGAGGGGCCG GCTCCCGGCG
1601  CGCGCGCGCG TGCGTGTCTG CGCGGGCGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTCTGTG TCAGAGACGG
1681  CACAAGAGCG CGCGGTTTCC CAACAGCGGC GGGAGTTTCG GAAGCCTGGC CGGCTCAGCG TGACGTGTTC GCGGCCCCCC
1761  GGTCCCCTCC CATTCTCCCC CTCCCCACCC CAGGGTGACG CGCAGCCGGA GTGGAAGCAG TTTTGGCGGG CGAGCAGCGC
1841  CTTGCAGGAA ACTGACTCAT CACTACTCCC TCCAGCGGTC CGAGGCTCTG CCCACGCACC TCCCACTCCG CGCGTGATTT
1921  CCTGGAGGCC GGCGCCCCCT CCCGGCCCTG GCGGGAATAG CACACAGGCT TTCCCGCGGA GTGGGGCTGG CCGGCGCGAA
2001  CCGCCGCGGC TACTCCTGGG CTCATCCGAG ATCAACCCCT ATGCCATTAC CACCCCTTCA AAGGAGCACT CCTTAGGTTC
2081  AACAGTATTC ACTGAGCTCT TACTGGAAAT TAAAATATGG CTGAAGTCTA AGGCAGGAAG GCCAATAAAG GAGGCTATTT
2161  TTAATTGTTT CTAAAACAAG GGTTTGCGTT TCTGAGTTTT CTTTGGGCTG AAAGTTATTA TGAGCATGAG AGCAGATTTT
2241  GATGGGGGAG GAGAGGCCTA TGAGAGCCAT AAGAGAAGGA GGGGTGGTAG AAGAGGAGAG GGTGCCTGCC TAGATCCTAG
2321  TCCTGTCTTG AACTCCCGAG AGCCAGGGAA TATCCAGCAC CTTGATGAAG CCCTAGGCGG GCGCCTCCTC CTTGTGCCTA
2401  TGATGTATTG AGACCCAGAA TGTCCATTTC AAACATACCA GTGTGTCTCC GCTTGGCTGG CAACCCAAGA GTGCCCATCT
2481  GAGGAATTGT GCCAAACACT TGCTTGAATC TTCAATCTGG ATTAAGTTGG TCTCGGGAGG CAGGGCCTCA GCAATCTATA
2561  TTTTGAAAAA ACTCCCTAGG TGCTTTTCTT TCTTTCTTTT TTTCTTTCTT TCTTTCTTTC TTTCTTTCTT TCTTTCTTTC
2641  TTTCTTTCTT TCTTTTTCTT TCTTTCTTTC TTTTTCTTTC TTTTCTTTCT TTCTTTCTTT CTTTCTTTCT TTCTTTCTTT
2721  CTTTCTTCCT TTCTCTTTCT CTCTTTCTTT CTCTTTCTCT CTTTCTTTCT TTTCTTTCGA CAGAGTTGCA CTCTGTCACC
2801  CAGGCTGGAG TGCAATGGCA CCATCCTGGA CTCAAGTAGT CCTCCTGTTT CAGCCTCCCA AGTAACCGGG ACCACAGGCG
2881  TGATCCCCCC GCCCCCATGC CCAGATTTTT TTTTTTTTTT TTTTTTTTTT GAGATGCGGT CTCGCTCTGT CACCCAGGCT
2961  GGAGTGCAGT GGCGTGATCT CGGCTCACTG CAAGCTCCGC CTCCCGGGTT CACGCCATTC TCCTGCCTCA GCCTCCCGAG
3041  TAGCTGGGAC TACAGGTGCT GCCATCATGC CCGGCTAATT TTTTTTTGTA TTTTTAGTAG AGACGGGGTT TCACCGTGTT
3121  AGCCAGGATG GTCTCAATCT CCTGACCTCG TGCTCCGCCC TCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGAC
3201  ACTGCACCCA ACCACCCAGC TAATTTTTAT TTATTTTTAT TTTTAGTAGA GACAGGGTCT CAGCTAGTTG CCCAGGCTAG
3281  TCTTGGACCC TTGGGCTCAA ATGATTCTCC CACCTCTGCC TCCCAGAGTA TTAGGATTAC AGGCATAAGC CACTGCCCCT
3361  GGCCTCCCCA AGTGATTGTG ATGGGCCTCT CTGGTTAAGA AACCTCAAAA TTAGAGAGGG AGTGGGGTTC AATACTACAG
3441  CACAGGACTC AGGGCAAACA GGCCTGGGTT CAGATCCTGG CTGTGCCACT TATGAACTGT GTGATGTTAG GCAAGTTACT
3521  TAACTTATCT GAGCCTTGGT TGCCTCTTCT GTAAAAAGGG AGCTAATAGA TATCCACTTT TTAGGAGGAT TGATATTTTT
3601  AAACTGCTTA GAACAGCCCC CAAACATAAA AATATATAAA TAAATCCCAA CTCATGCCTA GCAGAGGGTG GATAGAGGTT
3681  ATTTGAGGGC TCTGTCCACT GTACTGGGTG ACCCCTTTAT GGGGCAGTGG CCTTTGGCCT TTTTAGCTGT ATGACTCAGG
3761  GGCAAGTCTC ATATCTCTTC CATCTCCTGC CCTTTAAACT TGGTGTGAAG TTACCAAGAG CCTCCTCTCC CAACCAGCTG
3841  GGACGTGAAA CTGTGGGCTC CACTGATCAC AAGCAGTGGG GTGAGGTGGG GTGGAGCAGA TGTGGCATGT GTCCCGGGCT
3921  TCCTGCCTCA TGAGGACTCA GCAGAGCTTT CACCCCCAGA AACTGCAAGT TGGGACTTGT CCCTAGGAAA ATCCAGTTGC
4001  TGCCAAGGTC GTGCAGTCAC TCAGCCCTGG AGTCAAGCCA GAGCAGGCAG GTAGGTGCCA GGGCTCCCTC ATGGGCAAAC
4081  TCACTCTCCG TTTTCCCTCT CCTGAAGGGG GAGGAGAGGA GCCAGGTAGA CCAGCCACCT TTAATTTTCT TTTTGCCTGC
4161  AAAACGGTTT CCTTGGACAC AGGCAACACG AGGCAGGGGC TGCCAGGTGT CTAGACTTCA GATCACCTGA TGTGCCTGGC
4241  AGGATGTGGC TCAGCCTGGG AGAAATCATC CCTTGCGCTG CCCCGCCCGG CCCCTCCTTA CCCCTAGGCC ACCCGCCTGA
4321  CGACATCCTT GGGAAAGGCC CTCAGCCTAC AGCACCTGTC AGCTGCTGTC TGAAGGAGGT AGTTGGCAGG GGGAAGTGAT
4401  AGGGGGGAGG CTCAGTAAAA CTGAAGGCAG AGAGGAATAA TCATACTTCT GTTTTCAATG CACTTCTCTA TACGAAGTGC
4481  TGCTGGCACG TTACCTACAT TAACTCAGTT AATTCTCATG TCTATCCTCT GAGACAGTCA CTATTACTAT CCCCATTTTA
4561  TAGATGAGGA AACTAGAGCT CAGACAAGTT AAGTTGCTTG CCCAGGGTCA CCTAGTAAAA CCTGGACTCC AGCCCAGGTG
4641  ATCTGGCTCC AGAGCCCTCC TGCTTAACCA CCAGGATACA GCCTTTCATT CAGCTCTGTT CTGTCTGCCT TGCTGCATGG
4721  ACTCTGTGAT CAATTTCTTG AGTATGTGTC TGTAGCCATG CTCTTTAAAC TTGTACATGG CCCCATTTAT GGATGAGGAA
4801  ACTGAGACCT AGAGACATTA AGTGGCTTTT TAAAGCTTAC GTAGTAACTG GCAGAGCTAG GACCACAACC CGGGTGCTTT
4881  TTGCCCCAAA GTCCCGGGTA CTTTTACTTG GCAGAGCAGG GTTACCCTAC TTGGGGATCT GGGTCGGGGG ACTTAGGAGG
4961  CTGGAGGAAC TGTCAGACTG TTTCTTCTTT TGGGAATTGA CCTTCTGGCC AGGGCTGCGA TTAGGAAACT GCTGGACTCT
5041  GGCAATTCAC ACATATTTGG GGGGCATTCA CACCCATGAG GGACACCTCT GGGGGGAAAA CAAATTGATT TTAGCTGATA
5121  ATACCTGGTG GCAAACAGGA CCCTGGTCCT TGCTCTTGCA ATAGACTTGC CTTTGTTGAC ATTAGCTTGC CCTTCAGTTG
5201  CCTGCTCTCC CAGTGACCTT GGTGTGCCAG GCTGGCTGAG CTCTGCTGGT GGGGGTCAGG CCTCCTGTGG GAAGGAAGCA
5281  GGAAGACCAG CTGGAAGGAG TGAGAGAGAC CCTCTGGTAG GAAGACGTCA CCTGAGGTGA CACAGCAAAG CCCGGCCAGG
5361  TAACATAGTG TCTAATCTCC GCCGTGACCA GGGCCTTCCT TGTATCTCTG CTGCAGGCGC CATGTCAGAA CCGGCTGGGG
5441  ATGTCCGTCA GAACCCATGC GGCAGCAAGG CCTGCCGCCG CCTCTTCGGC CCAGTGGACA GCGAGCAGCT GAGCCGCGAC
5521  TGTGATGCGC TAATGGCGGG CTGCATCCAG GAGGCCCGTG AGCGATGGAA CTTCGACTTT GTCACCGAGA CACCACTGGA
5601  GGGTGACTTC GCCTGGGAGC GTGTGCGGGG CCTTGGCCTG CCCAAGCTCT ACCTTCCCAC GGGGCCCCGG CGAGGCCGGG
5681  ATGAGTTGGG AGGAGGCAGG CGGCCTGGCA CCTCACCTGC TCTGCTGCAG GGGACAGCAG AGGAAGACCA TGTGGACCTG
5761  TCACTGTCTT GTACCCTTGT GCCTCGCTCA GGGGAGCAGG CTGAAGGGTC CCCAGGTGGA CCTGGAGACT CTCAGGGTCG
5841  AAAACGGCGG CAGACCAGCA TGACAGGTGC GGACATGTGC ACGGAAGGAC TTTGTAAGGG ACCAGGATTC TCAGAATCCA
5921  TGGTCCAAGG GCTGACCTGT CTGGTCCTGG TCCAGCATGC TCCAGGTAGA AGGAAACAGG CCCAGAGAGG GGAAGCAACC
6001  TCCCTGAGGT CACACAGCAA GTAGGCAGCA AAGACCAACT AGCTAACATT TATTGGGAAT GTTCATTATG CCAGGCCCTT
6081  TGCCAAGCTT CTAAGGTAGA TTTATTTAGT CCTTATAGCA ATGTTATAAC ATAAGACATT CTTGTCACCC TGCCCGCCTT
6161  TCTTTTTGAG ACAGGTGTCT TAACTCTGTT GGCCAGACTG GAGTGCAGTG ATACGATCAT GGCTCACTGC AGCTTCAAAC
6241  TCCTGGGCTC AAGCGATCTT CCTACCTCAG CCTCCTGGGT AGCTGGGAAG CTGGGACTAT AGTTGTACAC CACTACGCCC
6321  GGTTAATTTT TTGAGTTTTT GTAGAGACAA GGTCTCACCA TGTTGCCCGG GCTGGTCTTG AACTCCTGAG CTCAAGCAGT
6401  CCTCCTGCCT CAGCCTCCCA AAGTGTTGTG ATTACAGGCG TGAGCCACCA TGCCCAGCCC CTTGCCATCC TTTTAGGGCA
6481  AGGAAACCAG GCTCAGAGAG GTAGAGTGAT TTATCTAAGG TCTCAAAGTG AATTTGCCGT TGGGTCAAGA CTAATTATAA
6561  TAACAACAAC TACTGACGTT TATATGGGCC CGGCATTGTG CTGAACACTT TCATGGATTT TGTAACAGAA TCCCTAGATC
6641  AGCACTGTCC AGTAACTCTG CAGGGATGGG AGTGTCCGGT ACAGGGGCCA CGAGCCACAT ACGGCTGTTG TGCATTTGAC
6721  ACACAGCTCA TGTGACTGAG GAACTGAATT GTTCATTTTA TTTGATTGTA GTCTGTTTAA ACAAGCACAC AGAGCTAGTA
6801  GTGGTTCCTC TGCTGGGCAG CTTGACTTAG AGCAGACCCA TGGGTGCGGG TGCGGTGATG GATAAAATCA CATCTGTGAA
6881  GCATGGTGGG ACACTCCATA ATACCCCTCA AGAGACAGAG TGGACGTTCC CCGAGTTCTT CCTGTTCTCA GCAGTCGGCC
6961  CCATTGGCCC CAGGGAAGGG TGTCCTGGCC CCCCACTGTC TTCCTCAGTT GGGCAGCTCC GCCGCGTCCT CTTCTTCTTG
7041  GCCTGGCTGA CTTCTGCTGT CTCTCCTCAG ATTTCTACCA CTCCAAACGC CGGCTGATCT TCTCCAAGAG GAAGCCCTAA
7121  TCCGCCCACA GGAAGCCTGC AGTCCTGGAA GCGCGAGGGC CTCAAAGGCC CGCTCTACAT CTTCTGCCTT AGTCTCAGTT
7201  TGTGTGTCTT AATTATTATT TGTGTTTTAA TTTAAACACC TCCTCATGTA CATACCCTGG CCGCCCCCTG CCCCCCAGCC
7281  TCTGGCATTA GAATTATTTA AACAAAAACT AGGCGGTTGA ATGAGAGGTT CCTAAGAGTG CTGGGCATTT TTATTTTATG
7361  AAATACTATT TAAAGCCTCC TCATCCCGTG TTCTCCTTTT CCTCTCTCCC GGAGGTTGGG TGGGCCGGCT TCATGCCAGC
7441  TACTTCCTCC TCCCCACTTG TCCGCTGGGT GGTACCCTCT GGAGGGGTGT GGCTCCTTCC CATCGCTGTC ACAGGCGGTT
7521  ATGAAATTCA CCCCCTTTCC TGGACACTCA GACCTGAATT CTTTTTCATT TGAGAAGTAA ACAGATGGCA CTTTGAAGGG
7601  GCCTCACCGA GTGGGGGCAT CATCAAAAAC TTTGGAGTCC CCTCACCTCC TCTAAGGTTG GGCAGGGTGA CCCTGAAGTG
7681  AGCACAGCCT AGGGCTGAGC TGGGGACCTG GTACCCTCCT GGCTCTTGAT ACCCCCCTCT GTCTTGTGAA GGCAGGGGGA
7761  AGGTGGGGTC CTGGAGCAGA CCACCCCGCC TGCCCTCATG GCCCCTCTGA CCTGCACTGG GGAGCCCGTC TCAGTGTTGA
7841  GCCTTTTCCC TCTTTGGCTC CCCTGTACCT TTTGAGGAGC CCCAGCTACC CTTTTTCTCC AGCTGGGCTC TGCAATTCCC
7921  CTCTGCTGCT GTCCCTCCCC CTTGTCCTTT CCCTTCAGTA CCCTCTCAGC TCCAGGTGGC TCTGAGGTGC CTGTCCCACC
8001  CCCACCCCCA GCTCAATGGA CTGGAAGGGG AAGGGACACA CAAGAAGAAG GGCACCCTAG TTCTACCTCA GGCAGCTCAA
8081  GCAGCGACCG CCCCCTCCTC TAGCTGTGGG GGTGAGGGTC CCATGTGGTG GCACAGGCCC CCTTGAGTGG GGTTATCTCT
8161  GTGTTAGGGG TATATGATGG GGGAGTAGAT CTTTCTAGGA GGGAGACACT GGCCCCTCAA ATCGTCCAGC GACCTTCCTC
8241  ATCCACCCCA TCCCTCCCCA GTTCATTGCA CTTTGATTAG CAGCGGAACA AGGAGTCAGA CATTTTAAGA TGGTGGCAGT
8321  AGAGGCTATG GACAGGGCAT GCCACGTGGG CTCATATGGG GCTGGGAGTA GTTGTCTTTC CTGGCACTAA CGTTGAGCCC
8401  CTGGAGGCAC TGAAGTGCTT AGTGTACTTG GAGTATTGGG GTCTGACCCC AAACACCTTC CAGCTCCTGT AACATACTGG
8481  CCTGGACTGT TTTCTCTCGG CTCCCCATGT GTCCTGGTTC CCGTTTCTCC ACCTAGACTG TAAACCTCTC GAGGGCAGGG
8561  ACCACACCCT GTACTGTTCT GTGTCTTTCA CAGCTCCTCC CACAATGCTG AATATACAGC AGGTGCTCAA TAAATGATTC
8641  TTAGTGACTT T
>ref|Gene_ID:1026|CDKN1A|NC_000006.11:36646458...36655108 (+)
TGTATATCAGGGCCGCGCTGAGCTGCGCCAGCTGAGGTGTGAGCAGCTGCCGAAGTCAGTTCCTTGTGGAGCCGGAGCTG
GGCGCGGATTCGCCGAGGCACCGAGGCACTCAGAGGAGGTGAGAGAGCGGCGGCAGACAACAGGGGACCCCGGGCCGGCG
GCCCAGAGCCGAGCCAAGCGTGCCCGCGTGTGTCCCTGCGTGTCCGCGAGGATGCGTGTTCGCGGGTGTGTGCTGCGTTC
ACAGGTGTTTCTGCGGCAGGTGAATGACGGGCGTGGGTCGGTGCGCGCTCGGCTTGCGCACACGGTGTCTCTAAGTGCGC
GGGTGACGAGAGTCGGGATGTGCCGGAGACCCCGGGGCGGAGAGCGGGATTACAAGTACAGGAATCCCTGGTCACGCTCC
CCGCCCCTGGAAACCCAGCTGGGGCGAGGGAGGGCGTGGACGGGACCGTTCTGGGAGCTCGCCTTTGGCTGCGGTTGGCT
CCAGGCCCCAGGCGCAGTTTGCTCGCGGCGTGGGGATGAAGTCCGTGTCCCTGGAGGGGCCCAGGAAGGGCGAGGAAAGC
GGAGTGGAGTAAGTTCGTCTAGGATCGGTCCCGGGTGGCTCTGGGATCCAATCTGCGCCGCCCTGGCCCAGGTCCCAGGT
TCAGGTCCTTTACGCCACTGTGTCCACCACCTGGCTGAGCGCTGAGGTCAGCGCGGGCTGTTTCCTGGCCCTTGGGAATG
TGCCAGGACCCGTCCCCTAAGGACTAGCGAGGAGGTGACTCACTGTGACAAGGAGACCCCAGGGAACGGACTGTATGAGG
TCAGAACCCCGCCCGGGATGGGGTACAGCGGGACTCCAGAAGCCCTCTCCCCTGCCCCTTCGCGGTCTCCGTCCTCCCAT
CGGCACAGTGACCTATTTGGCTGGAACAGTTTGTTCCCAAGGAAGCCGGGCACTGGAGGTCCGGGACACCGCGTCGGGTC
CCCGCTCCGCGGCGCGCTGTAGGGGTCGGGGAGTCACGGCCCTGCTCTGGGCGGGCTCTAACCAGCCTGTCAGTCGGGGA
AGGGCAAGGGTCTCCTCTACCTCTTTCCCACCGCGGCCGGGAGAATCGCGGCCCAGCCTGTCCTCGGGTCGGGGCGCTGG
ACTCCGGGGCGGGAGCGGAGCCCACGCCTGGATGGGAGGCGGGGAGGGTTCATGTCTTTGAGGGGTGGGGGGTCTGGGGG
GCACGACGCTGCTCAGGGCCTCTATCAGCTGCCTCGGGGGCTCAGGGCTTCCCGACCTAGCCCAGATTCCCTCTCCGAAA
GCTACAGGGCTGAGCGGAGCAGGGGGGCGAGTCGCCCCCTGGGGCGCCGCCGCCTGGCGCGGACCACAGCGCGTCCTCTC
CGTCCCAAACCCCTGGGGGACACTTGCGCCCTCTTCGTGAGGAAAAGCATCTTGGAGCTGGGTTAGGAACTTGGGGCGCC
CAGGCAGCTTCCCCTCTCCTTGCCTCCCTCCACGTCGCGTTTCTGGGAGGACTTGCGAGCGGTTTTGTTTTCGTTGCTCC
CGTCTATTTTTATTTTCCAGGGATCTGACTCATCCCGTGCTTTGGGCGTGGAGATAAGGTGGAGGGGCCGGCTCCCGGCG
CGCGCGCGCGTGCGTGTCTGCGCGGGCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTCAGAGACGG
CACAAGAGCGCGCGGTTTCCCAACAGCGGCGGGAGTTTCGGAAGCCTGGCCGGCTCAGCGTGACGTGTTCGCGGCCCCCC
GGTCCCCTCCCATTCTCCCCCTCCCCACCCCAGGGTGACGCGCAGCCGGAGTGGAAGCAGTTTTGGCGGGCGAGCAGCGC
CTTGCAGGAAACTGACTCATCACTACTCCCTCCAGCGGTCCGAGGCTCTGCCCACGCACCTCCCACTCCGCGCGTGATTT
CCTGGAGGCCGGCGCCCCCTCCCGGCCCTGGCGGGAATAGCACACAGGCTTTCCCGCGGAGTGGGGCTGGCCGGCGCGAA
CCGCCGCGGCTACTCCTGGGCTCATCCGAGATCAACCCCTATGCCATTACCACCCCTTCAAAGGAGCACTCCTTAGGTTC
AACAGTATTCACTGAGCTCTTACTGGAAATTAAAATATGGCTGAAGTCTAAGGCAGGAAGGCCAATAAAGGAGGCTATTT
TTAATTGTTTCTAAAACAAGGGTTTGCGTTTCTGAGTTTTCTTTGGGCTGAAAGTTATTATGAGCATGAGAGCAGATTTT
GATGGGGGAGGAGAGGCCTATGAGAGCCATAAGAGAAGGAGGGGTGGTAGAAGAGGAGAGGGTGCCTGCCTAGATCCTAG
TCCTGTCTTGAACTCCCGAGAGCCAGGGAATATCCAGCACCTTGATGAAGCCCTAGGCGGGCGCCTCCTCCTTGTGCCTA
TGATGTATTGAGACCCAGAATGTCCATTTCAAACATACCAGTGTGTCTCCGCTTGGCTGGCAACCCAAGAGTGCCCATCT
GAGGAATTGTGCCAAACACTTGCTTGAATCTTCAATCTGGATTAAGTTGGTCTCGGGAGGCAGGGCCTCAGCAATCTATA
TTTTGAAAAAACTCCCTAGGTGCTTTTCTTTCTTTCTTTTTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTC
TTTCTTTCTTTCTTTTTCTTTCTTTCTTTCTTTTTCTTTCTTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTT
CTTTCTTCCTTTCTCTTTCTCTCTTTCTTTCTCTTTCTCTCTTTCTTTCTTTTCTTTCGACAGAGTTGCACTCTGTCACC
CAGGCTGGAGTGCAATGGCACCATCCTGGACTCAAGTAGTCCTCCTGTTTCAGCCTCCCAAGTAACCGGGACCACAGGCG
TGATCCCCCCGCCCCCATGCCCAGATTTTTTTTTTTTTTTTTTTTTTTTTGAGATGCGGTCTCGCTCTGTCACCCAGGCT
GGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAG
TAGCTGGGACTACAGGTGCTGCCATCATGCCCGGCTAATTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTT
AGCCAGGATGGTCTCAATCTCCTGACCTCGTGCTCCGCCCTCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGAC
ACTGCACCCAACCACCCAGCTAATTTTTATTTATTTTTATTTTTAGTAGAGACAGGGTCTCAGCTAGTTGCCCAGGCTAG
TCTTGGACCCTTGGGCTCAAATGATTCTCCCACCTCTGCCTCCCAGAGTATTAGGATTACAGGCATAAGCCACTGCCCCT
GGCCTCCCCAAGTGATTGTGATGGGCCTCTCTGGTTAAGAAACCTCAAAATTAGAGAGGGAGTGGGGTTCAATACTACAG
CACAGGACTCAGGGCAAACAGGCCTGGGTTCAGATCCTGGCTGTGCCACTTATGAACTGTGTGATGTTAGGCAAGTTACT
TAACTTATCTGAGCCTTGGTTGCCTCTTCTGTAAAAAGGGAGCTAATAGATATCCACTTTTTAGGAGGATTGATATTTTT
AAACTGCTTAGAACAGCCCCCAAACATAAAAATATATAAATAAATCCCAACTCATGCCTAGCAGAGGGTGGATAGAGGTT
ATTTGAGGGCTCTGTCCACTGTACTGGGTGACCCCTTTATGGGGCAGTGGCCTTTGGCCTTTTTAGCTGTATGACTCAGG
GGCAAGTCTCATATCTCTTCCATCTCCTGCCCTTTAAACTTGGTGTGAAGTTACCAAGAGCCTCCTCTCCCAACCAGCTG
GGACGTGAAACTGTGGGCTCCACTGATCACAAGCAGTGGGGTGAGGTGGGGTGGAGCAGATGTGGCATGTGTCCCGGGCT
TCCTGCCTCATGAGGACTCAGCAGAGCTTTCACCCCCAGAAACTGCAAGTTGGGACTTGTCCCTAGGAAAATCCAGTTGC
TGCCAAGGTCGTGCAGTCACTCAGCCCTGGAGTCAAGCCAGAGCAGGCAGGTAGGTGCCAGGGCTCCCTCATGGGCAAAC
TCACTCTCCGTTTTCCCTCTCCTGAAGGGGGAGGAGAGGAGCCAGGTAGACCAGCCACCTTTAATTTTCTTTTTGCCTGC
AAAACGGTTTCCTTGGACACAGGCAACACGAGGCAGGGGCTGCCAGGTGTCTAGACTTCAGATCACCTGATGTGCCTGGC
AGGATGTGGCTCAGCCTGGGAGAAATCATCCCTTGCGCTGCCCCGCCCGGCCCCTCCTTACCCCTAGGCCACCCGCCTGA
CGACATCCTTGGGAAAGGCCCTCAGCCTACAGCACCTGTCAGCTGCTGTCTGAAGGAGGTAGTTGGCAGGGGGAAGTGAT
AGGGGGGAGGCTCAGTAAAACTGAAGGCAGAGAGGAATAATCATACTTCTGTTTTCAATGCACTTCTCTATACGAAGTGC
TGCTGGCACGTTACCTACATTAACTCAGTTAATTCTCATGTCTATCCTCTGAGACAGTCACTATTACTATCCCCATTTTA
TAGATGAGGAAACTAGAGCTCAGACAAGTTAAGTTGCTTGCCCAGGGTCACCTAGTAAAACCTGGACTCCAGCCCAGGTG
ATCTGGCTCCAGAGCCCTCCTGCTTAACCACCAGGATACAGCCTTTCATTCAGCTCTGTTCTGTCTGCCTTGCTGCATGG
ACTCTGTGATCAATTTCTTGAGTATGTGTCTGTAGCCATGCTCTTTAAACTTGTACATGGCCCCATTTATGGATGAGGAA
ACTGAGACCTAGAGACATTAAGTGGCTTTTTAAAGCTTACGTAGTAACTGGCAGAGCTAGGACCACAACCCGGGTGCTTT
TTGCCCCAAAGTCCCGGGTACTTTTACTTGGCAGAGCAGGGTTACCCTACTTGGGGATCTGGGTCGGGGGACTTAGGAGG
CTGGAGGAACTGTCAGACTGTTTCTTCTTTTGGGAATTGACCTTCTGGCCAGGGCTGCGATTAGGAAACTGCTGGACTCT
GGCAATTCACACATATTTGGGGGGCATTCACACCCATGAGGGACACCTCTGGGGGGAAAACAAATTGATTTTAGCTGATA
ATACCTGGTGGCAAACAGGACCCTGGTCCTTGCTCTTGCAATAGACTTGCCTTTGTTGACATTAGCTTGCCCTTCAGTTG
CCTGCTCTCCCAGTGACCTTGGTGTGCCAGGCTGGCTGAGCTCTGCTGGTGGGGGTCAGGCCTCCTGTGGGAAGGAAGCA
GGAAGACCAGCTGGAAGGAGTGAGAGAGACCCTCTGGTAGGAAGACGTCACCTGAGGTGACACAGCAAAGCCCGGCCAGG
TAACATAGTGTCTAATCTCCGCCGTGACCAGGGCCTTCCTTGTATCTCTGCTGCAGGCGCCATGTCAGAACCGGCTGGGG
ATGTCCGTCAGAACCCATGCGGCAGCAAGGCCTGCCGCCGCCTCTTCGGCCCAGTGGACAGCGAGCAGCTGAGCCGCGAC
TGTGATGCGCTAATGGCGGGCTGCATCCAGGAGGCCCGTGAGCGATGGAACTTCGACTTTGTCACCGAGACACCACTGGA
GGGTGACTTCGCCTGGGAGCGTGTGCGGGGCCTTGGCCTGCCCAAGCTCTACCTTCCCACGGGGCCCCGGCGAGGCCGGG
ATGAGTTGGGAGGAGGCAGGCGGCCTGGCACCTCACCTGCTCTGCTGCAGGGGACAGCAGAGGAAGACCATGTGGACCTG
TCACTGTCTTGTACCCTTGTGCCTCGCTCAGGGGAGCAGGCTGAAGGGTCCCCAGGTGGACCTGGAGACTCTCAGGGTCG
AAAACGGCGGCAGACCAGCATGACAGGTGCGGACATGTGCACGGAAGGACTTTGTAAGGGACCAGGATTCTCAGAATCCA
TGGTCCAAGGGCTGACCTGTCTGGTCCTGGTCCAGCATGCTCCAGGTAGAAGGAAACAGGCCCAGAGAGGGGAAGCAACC
TCCCTGAGGTCACACAGCAAGTAGGCAGCAAAGACCAACTAGCTAACATTTATTGGGAATGTTCATTATGCCAGGCCCTT
TGCCAAGCTTCTAAGGTAGATTTATTTAGTCCTTATAGCAATGTTATAACATAAGACATTCTTGTCACCCTGCCCGCCTT
TCTTTTTGAGACAGGTGTCTTAACTCTGTTGGCCAGACTGGAGTGCAGTGATACGATCATGGCTCACTGCAGCTTCAAAC
TCCTGGGCTCAAGCGATCTTCCTACCTCAGCCTCCTGGGTAGCTGGGAAGCTGGGACTATAGTTGTACACCACTACGCCC
GGTTAATTTTTTGAGTTTTTGTAGAGACAAGGTCTCACCATGTTGCCCGGGCTGGTCTTGAACTCCTGAGCTCAAGCAGT
CCTCCTGCCTCAGCCTCCCAAAGTGTTGTGATTACAGGCGTGAGCCACCATGCCCAGCCCCTTGCCATCCTTTTAGGGCA
AGGAAACCAGGCTCAGAGAGGTAGAGTGATTTATCTAAGGTCTCAAAGTGAATTTGCCGTTGGGTCAAGACTAATTATAA
TAACAACAACTACTGACGTTTATATGGGCCCGGCATTGTGCTGAACACTTTCATGGATTTTGTAACAGAATCCCTAGATC
AGCACTGTCCAGTAACTCTGCAGGGATGGGAGTGTCCGGTACAGGGGCCACGAGCCACATACGGCTGTTGTGCATTTGAC
ACACAGCTCATGTGACTGAGGAACTGAATTGTTCATTTTATTTGATTGTAGTCTGTTTAAACAAGCACACAGAGCTAGTA
GTGGTTCCTCTGCTGGGCAGCTTGACTTAGAGCAGACCCATGGGTGCGGGTGCGGTGATGGATAAAATCACATCTGTGAA
GCATGGTGGGACACTCCATAATACCCCTCAAGAGACAGAGTGGACGTTCCCCGAGTTCTTCCTGTTCTCAGCAGTCGGCC
CCATTGGCCCCAGGGAAGGGTGTCCTGGCCCCCCACTGTCTTCCTCAGTTGGGCAGCTCCGCCGCGTCCTCTTCTTCTTG
GCCTGGCTGACTTCTGCTGTCTCTCCTCAGATTTCTACCACTCCAAACGCCGGCTGATCTTCTCCAAGAGGAAGCCCTAA
TCCGCCCACAGGAAGCCTGCAGTCCTGGAAGCGCGAGGGCCTCAAAGGCCCGCTCTACATCTTCTGCCTTAGTCTCAGTT
TGTGTGTCTTAATTATTATTTGTGTTTTAATTTAAACACCTCCTCATGTACATACCCTGGCCGCCCCCTGCCCCCCAGCC
TCTGGCATTAGAATTATTTAAACAAAAACTAGGCGGTTGAATGAGAGGTTCCTAAGAGTGCTGGGCATTTTTATTTTATG
AAATACTATTTAAAGCCTCCTCATCCCGTGTTCTCCTTTTCCTCTCTCCCGGAGGTTGGGTGGGCCGGCTTCATGCCAGC
TACTTCCTCCTCCCCACTTGTCCGCTGGGTGGTACCCTCTGGAGGGGTGTGGCTCCTTCCCATCGCTGTCACAGGCGGTT
ATGAAATTCACCCCCTTTCCTGGACACTCAGACCTGAATTCTTTTTCATTTGAGAAGTAAACAGATGGCACTTTGAAGGG
GCCTCACCGAGTGGGGGCATCATCAAAAACTTTGGAGTCCCCTCACCTCCTCTAAGGTTGGGCAGGGTGACCCTGAAGTG
AGCACAGCCTAGGGCTGAGCTGGGGACCTGGTACCCTCCTGGCTCTTGATACCCCCCTCTGTCTTGTGAAGGCAGGGGGA
AGGTGGGGTCCTGGAGCAGACCACCCCGCCTGCCCTCATGGCCCCTCTGACCTGCACTGGGGAGCCCGTCTCAGTGTTGA
GCCTTTTCCCTCTTTGGCTCCCCTGTACCTTTTGAGGAGCCCCAGCTACCCTTTTTCTCCAGCTGGGCTCTGCAATTCCC
CTCTGCTGCTGTCCCTCCCCCTTGTCCTTTCCCTTCAGTACCCTCTCAGCTCCAGGTGGCTCTGAGGTGCCTGTCCCACC
CCCACCCCCAGCTCAATGGACTGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCTAGTTCTACCTCAGGCAGCTCAA
GCAGCGACCGCCCCCTCCTCTAGCTGTGGGGGTGAGGGTCCCATGTGGTGGCACAGGCCCCCTTGAGTGGGGTTATCTCT
GTGTTAGGGGTATATGATGGGGGAGTAGATCTTTCTAGGAGGGAGACACTGGCCCCTCAAATCGTCCAGCGACCTTCCTC
ATCCACCCCATCCCTCCCCAGTTCATTGCACTTTGATTAGCAGCGGAACAAGGAGTCAGACATTTTAAGATGGTGGCAGT
AGAGGCTATGGACAGGGCATGCCACGTGGGCTCATATGGGGCTGGGAGTAGTTGTCTTTCCTGGCACTAACGTTGAGCCC
CTGGAGGCACTGAAGTGCTTAGTGTACTTGGAGTATTGGGGTCTGACCCCAAACACCTTCCAGCTCCTGTAACATACTGG
CCTGGACTGTTTTCTCTCGGCTCCCCATGTGTCCTGGTTCCCGTTTCTCCACCTAGACTGTAAACCTCTCGAGGGCAGGG
ACCACACCCTGTACTGTTCTGTGTCTTTCACAGCTCCTCCCACAATGCTGAATATACAGCAGGTGCTCAATAAATGATTC
TTAGTGACTTT