Look for Gene | Autophagy database

(CDKN1B) cyclin-dependent kinase inhibitor 1B (p27, Kip1) [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	6902
Official symbol	CDKN1B
Official name	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene type	gene with protein product
Organism	Homo sapiens
Location	Chromosome 12 (NC_000012.11) : 12870301...12875304 (+)
Map	12p13.1-p12
Length	5004 nt

Alternative name(s) and Synynom(s)

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Synonyms	MEN4; MEN1B; CDKN4; P27KIP1; KIP1

External Links

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Ensembl	ENSG00000111276
Entrez	1027
HGNC	1785
HPRD	02867

Comment

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Summary

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Bibliography

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Related Articles in PubMed

Genomic Context

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Go to ensembl

Sequence

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	FASTA

1	TCTTCTTCGT	CAGCCTCCCT	TCCACCGCCA	TATTGGGCCA	CTAAAAAAAG	GGGGCTCGTC	TTTTCGGGGT	GTTTTTCTCC
81	CCCTCCCCTG	TCCCCGCTTG	CTCACGGCTC	TGCGACTCCG	ACGCCGGCAA	GGTTTGGAGA	GCGGCTGGGT	TCGCGGGACC
161	CGCGGGCTTG	CACCCGCCCA	GACTCGGACG	GGCTTTGCCA	CCCTCTCCGC	TTGCCTGGTC	CCCTCTCCTC	TCCGCCCTCC
241	CGCTCGCCAG	TCCATTTGAT	CAGCGGAGAC	TCGGCGGCCG	GGCCGGGGCT	TCCCCGCAGC	CCCTGCGCGC	TCCTAGAGCT
321	CGGGCCGTGG	CTCGTCGGGG	TCTGTGTCTT	TTGGCTCCGA	GGGCAGTCGC	TGGGCTTCCG	AGAGGGGTTC	GGGCTGCGTA
401	GGGGCGCTTT	GTTTTGTTCG	GTTTTGTTTT	TTTGAGAGTG	CGAGAGAGGC	GGTCGTGCAG	ACCCGGGAGA	AAGATGTCAA
481	ACGTGCGAGT	GTCTAACGGG	AGCCCTAGCC	TGGAGCGGAT	GGACGCCAGG	CAGGCGGAGC	ACCCCAAGCC	CTCGGCCTGC
561	AGGAACCTCT	TCGGCCCGGT	GGACCACGAA	GAGTTAACCC	GGGACTTGGA	GAAGCACTGC	AGAGACATGG	AAGAGGCGAG
641	CCAGCGCAAG	TGGAATTTCG	ATTTTCAGAA	TCACAAACCC	CTAGAGGGCA	AGTACGAGTG	GCAAGAGGTG	GAGAAGGGCA
721	GCTTGCCCGA	GTTCTACTAC	AGACCCCCGC	GGCCCCCCAA	AGGTGCCTGC	AAGGTGCCGG	CGCAGGAGAG	CCAGGATGTC
801	AGCGGGAGCC	GCCCGGCGGC	GCCTTTAATT	GGGGCTCCGG	CTAACTCTGA	GGACACGCAT	TTGGTGGACC	CAAAGACTGA
881	TCCGTCGGAC	AGCCAGACGG	GGTTAGCGGA	GCAATGCGCA	GGAATAAGGA	AGCGACCTGC	AACCGACGGT	AATGACCCTT
961	TCCCAACCAT	AGAATGTGTT	TGGGGCCCCG	CTTTGCCTGC	TGGAGGGTGT	TAACCTTAGC	TTGCTTTTCG	GCGTATTCTG
1041	ATTTAGCTTT	GGGAGAGCTA	ACTTTATTGG	TCTTAGGTGT	TCAGTGCTAC	CTGGCCCACT	GCTTGTCTGT	TTGTGACTTT
1121	TAAGTCAGAA	ACTGGAGATG	GTAAGATCCG	ATAATTTCCC	TAACTTAATA	CATCGCGGTC	CCTCTCACTA	GCAACTCCTA
1201	GGTATGTGAC	AAAGTTGGGA	TGTTTATCAA	CGGTCCGCCT	CCTGGCTAGG	GAAAGAGCTC	TGGGGCGGAG	AATGCACTTT
1281	CTGTTTTTTG	AAAACAACCT	CATTTTGTGC	CCTTAAAAGC	CACTGGGGAT	GACGGATCCA	GGATTGTGGG	TGGAGGTAGT
1361	GGGTTTTTCA	TCCCCTGACT	ATGGGGCCAA	CTTCTGCCAG	CCATTGTTTT	TTCTAATAAA	GATTGTGTGT	TCTTTTTAAA
1441	AATTTCCCCT	GCGCTTAGAT	TCTTCTACTC	AAAACAAAAG	AGCCAACAGA	ACAGAAGAAA	ATGTTTCAGA	CGGTTCCCCA
1521	AATGCCGGTT	CTGTGGAGCA	GACGCCCAAG	AAGCCTGGCC	TCAGAAGACG	TCAAACGTAA	ACAGCTCGGT	GGGTTGATCA
1601	CTAAAGGAGC	ACGCACTGGA	ACCCGGGGCC	TTCAGACCTC	ACGATACCTG	ATCTTACTGG	TTGCTGGCAA	ATTAAAAGCT
1681	TATGGGGTTT	TGTTTTGTTT	ATACTTCGTG	AGGTCAAAAA	AGTAGCAATG	GGGAAGGCTG	GGGATACGGT	AATTCCTCAG
1761	AGTTTCTATG	CCCAGAGATA	CTTTCTCTTC	AAACTGTTGA	CCAGAGCAGC	TACTTGTAAC	CCAGGCCCCA	TCGGGTAGGA
1841	AGGTCGTTTC	CCTGTGAGTC	CCACTAAAAC	GTGTTGGGAG	CAATAGGTTC	TTTGCCCATC	CGAACAAGAA	CTAGGGTACT
1921	CCCTCAGTCC	GAATTAATGA	GAATTAATTT	CCTAGAGGTT	CAGCTTGAGT	CGGTAACAGA	TTTTGAGCCA	TACATGGAAA
2001	AATGGCAAAT	ACATGATTAA	GTTTCAATTT	TGAGGGGGAA	TGTTTGGTAG	AAATTGCTCA	TCTTTGGTTA	TGCAAGGGAT
2081	TAGAGATGTG	AATAGGATGG	TATGTTGTGT	TCTTTGACAT	TTTAATAAAC	TGTCACTTTC	CCTGTTGTCT	CCTAAGTTTG
2161	GAGAGAGAAG	GAACCAGTAT	TTGCAAAAAC	CAAATGGAAA	GATAAAAAAG	TTACTAAAGT	TTCTACAGAA	TTTCTGGTAA
2241	CACTGAAGTT	GCAAAGCAGA	AGTTAAATTA	ACTCTTGTCA	GTAAGCAATC	CAGGAACACG	TCAGCCAGTG	TATGCTAATT
2321	GTGCCGTAAC	AGGGTGATTT	GGATATTTGT	AGGGGAAATG	GGTAGTAAAT	ATCAAGACTG	GTGACCGTAG	GTCAGCCCAG
2401	CACAAAGGAA	GTGGAGATTT	TTCCATGCAC	AAGAATCTGA	TCACTGTAAA	TAGCTAATTT	GAATAATTCA	GTCCCCAGAT
2481	AACCAACATG	GGTTGGTTAT	TCATAATAAA	CTACATATTT	TAATAGTTTA	TTAGCTTCCT	TTAGACCAAG	ACTGTGACCT
2561	CTTTATTTTC	TAAAGCACAC	ACGTAGTTTA	GCATATGAGG	CGATAAAATA	TTGATGTTAA	CTTTTTAAAT	CCCCAGTTAT
2641	AAAAATTTTA	AAATAACAGG	GATTAAGGTG	AGATTCAGGT	TTGTTGTGTC	TTTAAATTGT	ATATGTGACT	TCACATATCT
2721	TTTTCAGCGC	TTATACAAAA	CGGCACTATA	GAACCTCCAT	TTTACAGCAC	CATATGAAGT	GGGAAAATTA	GGTGAAAATT
2801	TTCCTGAAGC	AACCTTAACA	TGCGCAGCCC	TTGTTGGTTT	GTGACTTGTG	GCCTAGCTCA	TCAGATGAGC	CACGAGAATC
2881	AGACCTGGAT	TTTGATCTGG	CCCTGTTCTG	ACATGCAATG	AGGCATTTGT	AGGATTTAGT	AATATTGCTA	GTTCAAAGAA
2961	TACTAGAAAT	ATTAGTAAGA	ACCTATTCAA	AAGTATTCAT	GAGTATTTTC	TGCATATGAA	TCAGGAATTA	GAATATTTTG
3041	AAAATGATGT	TAATAAAATT	TTCCTCTGGA	AGGCCTTTAT	AATTTTTATT	CCCAATCATT	TTTCAAATTT	AGAAAGTTTA
3121	ATCTGTCACA	GGAGAAAAAA	AATTAAAAAT	TTTCAAAAAT	TTAGAAAATT	TTTACCCGTA	AGTATTACAG	TTTCCTAATT
3201	ATCCTATTTA	TTTCCCACTT	GCCTTTGACC	TAGATTATTT	AGAGTAGGGT	TTCTCAGCCT	CTGCACTAAT	GACATTTTGG
3281	GCCGAATAAT	TCTGTTGTAG	GAGGCTGTCC	TGTGTGTTTT	AGATTGTTTG	GAATTATCCC	TGGCCTCTCA	CACTAGATGC
3361	CAGCAGTATC	CTCCTCCCCC	AGTGTGACAA	CCTAAAATGT	CTCCAGACAT	TGCCAAATGT	TCCCTGTGGG	GCGGGGGCAA
3441	CATTGCCTAC	TGTTAAGAAC	TACTGCTCTA	GACCAAAGAA	CACAGCACAG	AGGAAAGGAA	AAAAAAATCC	AGTTAAGAGA
3521	ATGTTAGGTG	GAGATGACTA	TAGTCATCAA	ACTTTTTTCC	CCATCAAGTA	TTTCCAAGCT	AACATAGTGA	CAAAATAATT
3601	CCTGTACTCT	ACTGGTAACG	TTAATCTAGT	GCTCTTCCTT	TAATTCTTCC	GTTTTGTTTT	CTTTTGCAGA	ATTAAGAATA
3681	TGTTTCCTTG	TTTATCAGAT	ACATCACTGC	TTGATGAAGC	AAGGAAGATA	TACATGAAAA	TTTTAAAAAT	ACATATCGCT
3761	GACTTCATGG	AATGGACATC	CTGTATAAGC	ACTGAAAAAC	AACAACACAA	TAACACTAAA	ATTTTAGGCA	CTCTTAAATG
3841	ATCTGCCTCT	AAAAGCGTTG	GATGTAGCAT	TATGCAATTA	GGTTTTTCCT	TATTTGCTTC	ATTGTACTAC	CTGTGTATAT
3921	AGTTTTTACC	TTTTATGTAG	CACATAAACT	TTGGGGAAGG	GAGGGCAGGG	TGGGGCTGAG	GAACTGACGT	GGAGCGGGGT
4001	ATGAAGAGCT	TGCTTTGATT	TACAGCAAGT	AGATAAATAT	TTGACTTGCA	TGAAGAGAAG	CAATTTTGGG	GAAGGGTTTG
4081	AATTGTTTTC	TTTAAAGATG	TAATGTCCCT	TTCAGAGACA	GCTGATACTT	CATTTAAAAA	AATCACAAAA	ATTTGAACAC
4161	TGGCTAAAGA	TAATTGCTAT	TTATTTTTAC	AAGAAGTTTA	TTCTCATTTG	GGAGATCTGG	TGATCTCCCA	AGCTATCTAA
4241	AGTTTGTTAG	ATAGCTGCAT	GTGGCTTTTT	TAAAAAAGCA	ACAGAAACCT	ATCCTCACTG	CCCTCCCCAG	TCTCTCTTAA
4321	AGTTGGAATT	TACCAGTTAA	TTACTCAGCA	GAATGGTGAT	CACTCCAGGT	AGTTTGGGGC	AAAAATCCGA	GGTGCTTGGG
4401	AGTTTTGAAT	GTTAAGAATT	GACCATCTGC	TTTTATTAAA	TTTGTTGACA	AAATTTTCTC	ATTTTCTTTT	CACTTCGGGC
4481	TGTGTAAACA	CAGTCAAAAT	AATTCTAAAT	CCCTCGATAT	TTTTAAAGAT	CTGTAAGTAA	CTTCACATTA	AAAAATGAAA
4561	TATTTTTTAA	TTTAAAGCTT	ACTCTGTCCA	TTTATCCACA	GGAAAGTGTT	ATTTTTCAAG	GAAGGTTCAT	GTAGAGAAAA
4641	GCACACTTGT	AGGATAAGTG	AAATGGATAC	TACATCTTTA	AACAGTATTT	CATTGCCTGT	GTATGGAAAA	ACCATTTGAA
4721	GTGTACCTGT	GTACATAACT	CTGTAAAAAC	ACTGAAAAAT	TATACTAACT	TATTTATGTT	AAAAGATTTT	TTTTAATCTA
4801	GACAATATAC	AAGCCAAAGT	GGCATGTTTT	GTGCATTTGT	AAATGCTGTG	TTGGGTAGAA	TAGGTTTTCC	CCTCTTTTGT
4881	TAAATAATAT	GGCTATGCTT	AAAAGGTTGC	ATACTGAGCC	AAGTATAATT	TTTTGTAATG	TGTGAAAAAG	ATGCCAATTA
4961	TTGTTACACA	TTAAGTAATC	AATAAAGAAA	ACTTCCATAG	CTAT

	>ref\|Gene_ID:1027\|CDKN1B\|NC_000012.11:12870301...12875304 (+) TCTTCTTCGTCAGCCTCCCTTCCACCGCCATATTGGGCCACTAAAAAAAGGGGGCTCGTCTTTTCGGGGTGTTTTTCTCC CCCTCCCCTGTCCCCGCTTGCTCACGGCTCTGCGACTCCGACGCCGGCAAGGTTTGGAGAGCGGCTGGGTTCGCGGGACC CGCGGGCTTGCACCCGCCCAGACTCGGACGGGCTTTGCCACCCTCTCCGCTTGCCTGGTCCCCTCTCCTCTCCGCCCTCC CGCTCGCCAGTCCATTTGATCAGCGGAGACTCGGCGGCCGGGCCGGGGCTTCCCCGCAGCCCCTGCGCGCTCCTAGAGCT CGGGCCGTGGCTCGTCGGGGTCTGTGTCTTTTGGCTCCGAGGGCAGTCGCTGGGCTTCCGAGAGGGGTTCGGGCTGCGTA GGGGCGCTTTGTTTTGTTCGGTTTTGTTTTTTTGAGAGTGCGAGAGAGGCGGTCGTGCAGACCCGGGAGAAAGATGTCAA ACGTGCGAGTGTCTAACGGGAGCCCTAGCCTGGAGCGGATGGACGCCAGGCAGGCGGAGCACCCCAAGCCCTCGGCCTGC AGGAACCTCTTCGGCCCGGTGGACCACGAAGAGTTAACCCGGGACTTGGAGAAGCACTGCAGAGACATGGAAGAGGCGAG CCAGCGCAAGTGGAATTTCGATTTTCAGAATCACAAACCCCTAGAGGGCAAGTACGAGTGGCAAGAGGTGGAGAAGGGCA GCTTGCCCGAGTTCTACTACAGACCCCCGCGGCCCCCCAAAGGTGCCTGCAAGGTGCCGGCGCAGGAGAGCCAGGATGTC AGCGGGAGCCGCCCGGCGGCGCCTTTAATTGGGGCTCCGGCTAACTCTGAGGACACGCATTTGGTGGACCCAAAGACTGA TCCGTCGGACAGCCAGACGGGGTTAGCGGAGCAATGCGCAGGAATAAGGAAGCGACCTGCAACCGACGGTAATGACCCTT TCCCAACCATAGAATGTGTTTGGGGCCCCGCTTTGCCTGCTGGAGGGTGTTAACCTTAGCTTGCTTTTCGGCGTATTCTG ATTTAGCTTTGGGAGAGCTAACTTTATTGGTCTTAGGTGTTCAGTGCTACCTGGCCCACTGCTTGTCTGTTTGTGACTTT TAAGTCAGAAACTGGAGATGGTAAGATCCGATAATTTCCCTAACTTAATACATCGCGGTCCCTCTCACTAGCAACTCCTA GGTATGTGACAAAGTTGGGATGTTTATCAACGGTCCGCCTCCTGGCTAGGGAAAGAGCTCTGGGGCGGAGAATGCACTTT CTGTTTTTTGAAAACAACCTCATTTTGTGCCCTTAAAAGCCACTGGGGATGACGGATCCAGGATTGTGGGTGGAGGTAGT GGGTTTTTCATCCCCTGACTATGGGGCCAACTTCTGCCAGCCATTGTTTTTTCTAATAAAGATTGTGTGTTCTTTTTAAA AATTTCCCCTGCGCTTAGATTCTTCTACTCAAAACAAAAGAGCCAACAGAACAGAAGAAAATGTTTCAGACGGTTCCCCA AATGCCGGTTCTGTGGAGCAGACGCCCAAGAAGCCTGGCCTCAGAAGACGTCAAACGTAAACAGCTCGGTGGGTTGATCA CTAAAGGAGCACGCACTGGAACCCGGGGCCTTCAGACCTCACGATACCTGATCTTACTGGTTGCTGGCAAATTAAAAGCT TATGGGGTTTTGTTTTGTTTATACTTCGTGAGGTCAAAAAAGTAGCAATGGGGAAGGCTGGGGATACGGTAATTCCTCAG AGTTTCTATGCCCAGAGATACTTTCTCTTCAAACTGTTGACCAGAGCAGCTACTTGTAACCCAGGCCCCATCGGGTAGGA AGGTCGTTTCCCTGTGAGTCCCACTAAAACGTGTTGGGAGCAATAGGTTCTTTGCCCATCCGAACAAGAACTAGGGTACT CCCTCAGTCCGAATTAATGAGAATTAATTTCCTAGAGGTTCAGCTTGAGTCGGTAACAGATTTTGAGCCATACATGGAAA AATGGCAAATACATGATTAAGTTTCAATTTTGAGGGGGAATGTTTGGTAGAAATTGCTCATCTTTGGTTATGCAAGGGAT TAGAGATGTGAATAGGATGGTATGTTGTGTTCTTTGACATTTTAATAAACTGTCACTTTCCCTGTTGTCTCCTAAGTTTG GAGAGAGAAGGAACCAGTATTTGCAAAAACCAAATGGAAAGATAAAAAAGTTACTAAAGTTTCTACAGAATTTCTGGTAA CACTGAAGTTGCAAAGCAGAAGTTAAATTAACTCTTGTCAGTAAGCAATCCAGGAACACGTCAGCCAGTGTATGCTAATT GTGCCGTAACAGGGTGATTTGGATATTTGTAGGGGAAATGGGTAGTAAATATCAAGACTGGTGACCGTAGGTCAGCCCAG CACAAAGGAAGTGGAGATTTTTCCATGCACAAGAATCTGATCACTGTAAATAGCTAATTTGAATAATTCAGTCCCCAGAT AACCAACATGGGTTGGTTATTCATAATAAACTACATATTTTAATAGTTTATTAGCTTCCTTTAGACCAAGACTGTGACCT CTTTATTTTCTAAAGCACACACGTAGTTTAGCATATGAGGCGATAAAATATTGATGTTAACTTTTTAAATCCCCAGTTAT AAAAATTTTAAAATAACAGGGATTAAGGTGAGATTCAGGTTTGTTGTGTCTTTAAATTGTATATGTGACTTCACATATCT TTTTCAGCGCTTATACAAAACGGCACTATAGAACCTCCATTTTACAGCACCATATGAAGTGGGAAAATTAGGTGAAAATT TTCCTGAAGCAACCTTAACATGCGCAGCCCTTGTTGGTTTGTGACTTGTGGCCTAGCTCATCAGATGAGCCACGAGAATC AGACCTGGATTTTGATCTGGCCCTGTTCTGACATGCAATGAGGCATTTGTAGGATTTAGTAATATTGCTAGTTCAAAGAA TACTAGAAATATTAGTAAGAACCTATTCAAAAGTATTCATGAGTATTTTCTGCATATGAATCAGGAATTAGAATATTTTG AAAATGATGTTAATAAAATTTTCCTCTGGAAGGCCTTTATAATTTTTATTCCCAATCATTTTTCAAATTTAGAAAGTTTA ATCTGTCACAGGAGAAAAAAAATTAAAAATTTTCAAAAATTTAGAAAATTTTTACCCGTAAGTATTACAGTTTCCTAATT ATCCTATTTATTTCCCACTTGCCTTTGACCTAGATTATTTAGAGTAGGGTTTCTCAGCCTCTGCACTAATGACATTTTGG GCCGAATAATTCTGTTGTAGGAGGCTGTCCTGTGTGTTTTAGATTGTTTGGAATTATCCCTGGCCTCTCACACTAGATGC CAGCAGTATCCTCCTCCCCCAGTGTGACAACCTAAAATGTCTCCAGACATTGCCAAATGTTCCCTGTGGGGCGGGGGCAA CATTGCCTACTGTTAAGAACTACTGCTCTAGACCAAAGAACACAGCACAGAGGAAAGGAAAAAAAAATCCAGTTAAGAGA ATGTTAGGTGGAGATGACTATAGTCATCAAACTTTTTTCCCCATCAAGTATTTCCAAGCTAACATAGTGACAAAATAATT CCTGTACTCTACTGGTAACGTTAATCTAGTGCTCTTCCTTTAATTCTTCCGTTTTGTTTTCTTTTGCAGAATTAAGAATA TGTTTCCTTGTTTATCAGATACATCACTGCTTGATGAAGCAAGGAAGATATACATGAAAATTTTAAAAATACATATCGCT GACTTCATGGAATGGACATCCTGTATAAGCACTGAAAAACAACAACACAATAACACTAAAATTTTAGGCACTCTTAAATG ATCTGCCTCTAAAAGCGTTGGATGTAGCATTATGCAATTAGGTTTTTCCTTATTTGCTTCATTGTACTACCTGTGTATAT AGTTTTTACCTTTTATGTAGCACATAAACTTTGGGGAAGGGAGGGCAGGGTGGGGCTGAGGAACTGACGTGGAGCGGGGT ATGAAGAGCTTGCTTTGATTTACAGCAAGTAGATAAATATTTGACTTGCATGAAGAGAAGCAATTTTGGGGAAGGGTTTG AATTGTTTTCTTTAAAGATGTAATGTCCCTTTCAGAGACAGCTGATACTTCATTTAAAAAAATCACAAAAATTTGAACAC TGGCTAAAGATAATTGCTATTTATTTTTACAAGAAGTTTATTCTCATTTGGGAGATCTGGTGATCTCCCAAGCTATCTAA AGTTTGTTAGATAGCTGCATGTGGCTTTTTTAAAAAAGCAACAGAAACCTATCCTCACTGCCCTCCCCAGTCTCTCTTAA AGTTGGAATTTACCAGTTAATTACTCAGCAGAATGGTGATCACTCCAGGTAGTTTGGGGCAAAAATCCGAGGTGCTTGGG AGTTTTGAATGTTAAGAATTGACCATCTGCTTTTATTAAATTTGTTGACAAAATTTTCTCATTTTCTTTTCACTTCGGGC TGTGTAAACACAGTCAAAATAATTCTAAATCCCTCGATATTTTTAAAGATCTGTAAGTAACTTCACATTAAAAAATGAAA TATTTTTTAATTTAAAGCTTACTCTGTCCATTTATCCACAGGAAAGTGTTATTTTTCAAGGAAGGTTCATGTAGAGAAAA GCACACTTGTAGGATAAGTGAAATGGATACTACATCTTTAAACAGTATTTCATTGCCTGTGTATGGAAAAACCATTTGAA GTGTACCTGTGTACATAACTCTGTAAAAACACTGAAAAATTATACTAACTTATTTATGTTAAAAGATTTTTTTTAATCTA GACAATATACAAGCCAAAGTGGCATGTTTTGTGCATTTGTAAATGCTGTGTTGGGTAGAATAGGTTTTCCCCTCTTTTGT TAAATAATATGGCTATGCTTAAAAGGTTGCATACTGAGCCAAGTATAATTTTTTGTAATGTGTGAAAAAGATGCCAATTA TTGTTACACATTAAGTAATCAATAAAGAAAACTTCCATAGCTAT

CDKN1B, mRNA isoform 1 - Generality

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Primary source

RefSeq : NM_004064.3 (GI:207113192)

Name

Cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)

Type of transcript

mRNA

Organism

Homo sapiens

Length

2413 nt

Map

12p13.1-p12

Location

Chromosome 12 (NC_000012.11) strand : +

12870301...12871247

12871758...12871887

12873969...12875304

Exon(s)

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Exon(s)	Start	End	Length	is coding
Exon 1	1	947	947	1
Exon 2	948	1077	130	1
Exon 3	1078	2413	1336	1

Variation(s)

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ID	Class	Location	Mutation	Length	is synonymous	Source
rs11550615	SNP	102	c/g	1	?	dbSNP
rs3093728	SNP	207	c/g	1	?	dbSNP
rs34330	SNP	394	c/t	1	?	dbSNP
rs2066828	SNP	515	c/t	1	?	dbSNP
rs16908375	SNP	637	a/g	1	?	dbSNP
rs35456792	SNP	640	c/t	1	?	dbSNP
rs2066827	SNP	798	g/t	1	?	dbSNP
rs73281150	SNP	1049	c/t	1	?	dbSNP
rs4251696	SNP	1250	c/t	1	?	dbSNP
rs1042935	SNP	1436	a/g	1	?	dbSNP
rs4251697	SNP	1570	a/g	1	?	dbSNP
rs4251698	SNP	1679	a/t	1	?	dbSNP
rs1042937	SNP	1874	c/t	1	?	dbSNP
rs7330	SNP	2025	a/c	1	?	dbSNP
rs10237	SNP	2113	g/t	1	?	dbSNP

CDS

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Primary source

NCBI : CCDS8653

Nucleotide

CDKN1B, mRNA isoform 1[NM_004064.3] : 473...1069

Length

597

Location

Chromosome 12 (NC_000012.11) strand : +

12870773...12871247

12871758...12871879

Start codon

Translation

NP_004055.1

Sequence

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	FASTA

1	CTTCTTCGTC	AGCCTCCCTT	CCACCGCCAT	ATTGGGCCAC	TAAAAAAAGG	GGGCTCGTCT	TTTCGGGGTG	TTTTTCTCCC
81	CCTCCCCTGT	CCCCGCTTGC	TCACGGCTCT	GCGACTCCGA	CGCCGGCAAG	GTTTGGAGAG	CGGCTGGGTT	CGCGGGACCC
161	GCGGGCTTGC	ACCCGCCCAG	ACTCGGACGG	GCTTTGCCAC	CCTCTCCGCT	TGCCTGGTCC	CCTCTCCTCT	CCGCCCTCCC
241	GCTCGCCAGT	CCATTTGATC	AGCGGAGACT	CGGCGGCCGG	GCCGGGGCTT	CCCCGCAGCC	CCTGCGCGCT	CCTAGAGCTC
321	GGGCCGTGGC	TCGTCGGGGT	CTGTGTCTTT	TGGCTCCGAG	GGCAGTCGCT	GGGCTTCCGA	GAGGGGTTCG	GGCTGCGTAG
401	GGGCGCTTTG	TTTTGTTCGG	TTTTGTTTTT	TTGAGAGTGC	GAGAGAGGCG	GTCGTGCAGA	CCCGGGAGAA	AGATGTCAAA
481	CGTGCGAGTG	TCTAACGGGA	GCCCTAGCCT	GGAGCGGATG	GACGCCAGGC	AGGCGGAGCA	CCCCAAGCCC	TCGGCCTGCA
561	GGAACCTCTT	CGGCCCGGTG	GACCACGAAG	AGTTAACCCG	GGACTTGGAG	AAGCACTGCA	GAGACATGGA	AGAGGCGAGC
641	CAGCGCAAGT	GGAATTTCGA	TTTTCAGAAT	CACAAACCCC	TAGAGGGCAA	GTACGAGTGG	CAAGAGGTGG	AGAAGGGCAG
721	CTTGCCCGAG	TTCTACTACA	GACCCCCGCG	GCCCCCCAAA	GGTGCCTGCA	AGGTGCCGGC	GCAGGAGAGC	CAGGATGTCA
801	GCGGGAGCCG	CCCGGCGGCG	CCTTTAATTG	GGGCTCCGGC	TAACTCTGAG	GACACGCATT	TGGTGGACCC	AAAGACTGAT
881	CCGTCGGACA	GCCAGACGGG	GTTAGCGGAG	CAATGCGCAG	GAATAAGGAA	GCGACCTGCA	ACCGACGATT	CTTCTACTCA
961	AAACAAAAGA	GCCAACAGAA	CAGAAGAAAA	TGTTTCAGAC	GGTTCCCCAA	ATGCCGGTTC	TGTGGAGCAG	ACGCCCAAGA
1041	AGCCTGGCCT	CAGAAGACGT	CAAACGTAAA	CAGCTCGAAT	TAAGAATATG	TTTCCTTGTT	TATCAGATAC	ATCACTGCTT
1121	GATGAAGCAA	GGAAGATATA	CATGAAAATT	TTAAAAATAC	ATATCGCTGA	CTTCATGGAA	TGGACATCCT	GTATAAGCAC
1201	TGAAAAACAA	CAACACAATA	ACACTAAAAT	TTTAGGCACT	CTTAAATGAT	CTGCCTCTAA	AAGCGTTGGA	TGTAGCATTA
1281	TGCAATTAGG	TTTTTCCTTA	TTTGCTTCAT	TGTACTACCT	GTGTATATAG	TTTTTACCTT	TTATGTAGCA	CATAAACTTT
1361	GGGGAAGGGA	GGGCAGGGTG	GGGCTGAGGA	ACTGACGTGG	AGCGGGGTAT	GAAGAGCTTG	CTTTGATTTA	CAGCAAGTAG
1441	ATAAATATTT	GACTTGCATG	AAGAGAAGCA	ATTTTGGGGA	AGGGTTTGAA	TTGTTTTCTT	TAAAGATGTA	ATGTCCCTTT
1521	CAGAGACAGC	TGATACTTCA	TTTAAAAAAA	TCACAAAAAT	TTGAACACTG	GCTAAAGATA	ATTGCTATTT	ATTTTTACAA
1601	GAAGTTTATT	CTCATTTGGG	AGATCTGGTG	ATCTCCCAAG	CTATCTAAAG	TTTGTTAGAT	AGCTGCATGT	GGCTTTTTTA
1681	AAAAAGCAAC	AGAAACCTAT	CCTCACTGCC	CTCCCCAGTC	TCTCTTAAAG	TTGGAATTTA	CCAGTTAATT	ACTCAGCAGA
1761	ATGGTGATCA	CTCCAGGTAG	TTTGGGGCAA	AAATCCGAGG	TGCTTGGGAG	TTTTGAATGT	TAAGAATTGA	CCATCTGCTT
1841	TTATTAAATT	TGTTGACAAA	ATTTTCTCAT	TTTCTTTTCA	CTTCGGGCTG	TGTAAACACA	GTCAAAATAA	TTCTAAATCC
1921	CTCGATATTT	TTAAAGATCT	GTAAGTAACT	TCACATTAAA	AAATGAAATA	TTTTTTAATT	TAAAGCTTAC	TCTGTCCATT
2001	TATCCACAGG	AAAGTGTTAT	TTTTCAAGGA	AGGTTCATGT	AGAGAAAAGC	ACACTTGTAG	GATAAGTGAA	ATGGATACTA
2081	CATCTTTAAA	CAGTATTTCA	TTGCCTGTGT	ATGGAAAAAC	CATTTGAAGT	GTACCTGTGT	ACATAACTCT	GTAAAAACAC
2161	TGAAAAATTA	TACTAACTTA	TTTATGTTAA	AAGATTTTTT	TTAATCTAGA	CAATATACAA	GCCAAAGTGG	CATGTTTTGT
2241	GCATTTGTAA	ATGCTGTGTT	GGGTAGAATA	GGTTTTCCCC	TCTTTTGTTA	AATAATATGG	CTATGCTTAA	AAGGTTGCAT
2321	ACTGAGCCAA	GTATAATTTT	TTGTAATGTG	TGAAAAAGAT	GCCAATTATT	GTTACACATT	AAGTAATCAA	TAAAGAAAAC
2401	TTCCATAGCT	ATT

	>gi\|207113192\|ref\|NM_004064.3\|Cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) CTTCTTCGTCAGCCTCCCTTCCACCGCCATATTGGGCCACTAAAAAAAGGGGGCTCGTCTTTTCGGGGTGTTTTTCTCCC CCTCCCCTGTCCCCGCTTGCTCACGGCTCTGCGACTCCGACGCCGGCAAGGTTTGGAGAGCGGCTGGGTTCGCGGGACCC GCGGGCTTGCACCCGCCCAGACTCGGACGGGCTTTGCCACCCTCTCCGCTTGCCTGGTCCCCTCTCCTCTCCGCCCTCCC GCTCGCCAGTCCATTTGATCAGCGGAGACTCGGCGGCCGGGCCGGGGCTTCCCCGCAGCCCCTGCGCGCTCCTAGAGCTC GGGCCGTGGCTCGTCGGGGTCTGTGTCTTTTGGCTCCGAGGGCAGTCGCTGGGCTTCCGAGAGGGGTTCGGGCTGCGTAG GGGCGCTTTGTTTTGTTCGGTTTTGTTTTTTTGAGAGTGCGAGAGAGGCGGTCGTGCAGACCCGGGAGAAAGATGTCAAA CGTGCGAGTGTCTAACGGGAGCCCTAGCCTGGAGCGGATGGACGCCAGGCAGGCGGAGCACCCCAAGCCCTCGGCCTGCA GGAACCTCTTCGGCCCGGTGGACCACGAAGAGTTAACCCGGGACTTGGAGAAGCACTGCAGAGACATGGAAGAGGCGAGC CAGCGCAAGTGGAATTTCGATTTTCAGAATCACAAACCCCTAGAGGGCAAGTACGAGTGGCAAGAGGTGGAGAAGGGCAG CTTGCCCGAGTTCTACTACAGACCCCCGCGGCCCCCCAAAGGTGCCTGCAAGGTGCCGGCGCAGGAGAGCCAGGATGTCA GCGGGAGCCGCCCGGCGGCGCCTTTAATTGGGGCTCCGGCTAACTCTGAGGACACGCATTTGGTGGACCCAAAGACTGAT CCGTCGGACAGCCAGACGGGGTTAGCGGAGCAATGCGCAGGAATAAGGAAGCGACCTGCAACCGACGATTCTTCTACTCA AAACAAAAGAGCCAACAGAACAGAAGAAAATGTTTCAGACGGTTCCCCAAATGCCGGTTCTGTGGAGCAGACGCCCAAGA AGCCTGGCCTCAGAAGACGTCAAACGTAAACAGCTCGAATTAAGAATATGTTTCCTTGTTTATCAGATACATCACTGCTT GATGAAGCAAGGAAGATATACATGAAAATTTTAAAAATACATATCGCTGACTTCATGGAATGGACATCCTGTATAAGCAC TGAAAAACAACAACACAATAACACTAAAATTTTAGGCACTCTTAAATGATCTGCCTCTAAAAGCGTTGGATGTAGCATTA TGCAATTAGGTTTTTCCTTATTTGCTTCATTGTACTACCTGTGTATATAGTTTTTACCTTTTATGTAGCACATAAACTTT GGGGAAGGGAGGGCAGGGTGGGGCTGAGGAACTGACGTGGAGCGGGGTATGAAGAGCTTGCTTTGATTTACAGCAAGTAG ATAAATATTTGACTTGCATGAAGAGAAGCAATTTTGGGGAAGGGTTTGAATTGTTTTCTTTAAAGATGTAATGTCCCTTT CAGAGACAGCTGATACTTCATTTAAAAAAATCACAAAAATTTGAACACTGGCTAAAGATAATTGCTATTTATTTTTACAA GAAGTTTATTCTCATTTGGGAGATCTGGTGATCTCCCAAGCTATCTAAAGTTTGTTAGATAGCTGCATGTGGCTTTTTTA AAAAAGCAACAGAAACCTATCCTCACTGCCCTCCCCAGTCTCTCTTAAAGTTGGAATTTACCAGTTAATTACTCAGCAGA ATGGTGATCACTCCAGGTAGTTTGGGGCAAAAATCCGAGGTGCTTGGGAGTTTTGAATGTTAAGAATTGACCATCTGCTT TTATTAAATTTGTTGACAAAATTTTCTCATTTTCTTTTCACTTCGGGCTGTGTAAACACAGTCAAAATAATTCTAAATCC CTCGATATTTTTAAAGATCTGTAAGTAACTTCACATTAAAAAATGAAATATTTTTTAATTTAAAGCTTACTCTGTCCATT TATCCACAGGAAAGTGTTATTTTTCAAGGAAGGTTCATGTAGAGAAAAGCACACTTGTAGGATAAGTGAAATGGATACTA CATCTTTAAACAGTATTTCATTGCCTGTGTATGGAAAAACCATTTGAAGTGTACCTGTGTACATAACTCTGTAAAAACAC TGAAAAATTATACTAACTTATTTATGTTAAAAGATTTTTTTTAATCTAGACAATATACAAGCCAAAGTGGCATGTTTTGT GCATTTGTAAATGCTGTGTTGGGTAGAATAGGTTTTCCCCTCTTTTGTTAAATAATATGGCTATGCTTAAAAGGTTGCAT ACTGAGCCAAGTATAATTTTTTGTAATGTGTGAAAAAGATGCCAATTATTGTTACACATTAAGTAATCAATAAAGAAAAC TTCCATAGCTATT

CDKN1B - Exon 1

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Exon number	1
Length	947 nt
Location	Chromosome 12 (NC_000012.11) : 12870301...12871247 (+)
Is part of	CDKN1B, mRNA isoform 1 (NM_004064.3)
Sequence	Show
	CTTCTTCGTCAGCCTCCCTTCCACCGCCATATTGGGCCACTAAAAAAAGGGGGCTCGTCTTTTCGGGGTGTTTTTCTCCC CCTCCCCTGTCCCCGCTTGCTCACGGCTCTGCGACTCCGACGCCGGCAAGGTTTGGAGAGCGGCTGGGTTCGCGGGACCC GCGGGCTTGCACCCGCCCAGACTCGGACGGGCTTTGCCACCCTCTCCGCTTGCCTGGTCCCCTCTCCTCTCCGCCCTCCC GCTCGCCAGTCCATTTGATCAGCGGAGACTCGGCGGCCGGGCCGGGGCTTCCCCGCAGCCCCTGCGCGCTCCTAGAGCTC GGGCCGTGGCTCGTCGGGGTCTGTGTCTTTTGGCTCCGAGGGCAGTCGCTGGGCTTCCGAGAGGGGTTCGGGCTGCGTAG GGGCGCTTTGTTTTGTTCGGTTTTGTTTTTTTGAGAGTGCGAGAGAGGCGGTCGTGCAGACCCGGGAGAAAGATGTCAAA CGTGCGAGTGTCTAACGGGAGCCCTAGCCTGGAGCGGATGGACGCCAGGCAGGCGGAGCACCCCAAGCCCTCGGCCTGCA GGAACCTCTTCGGCCCGGTGGACCACGAAGAGTTAACCCGGGACTTGGAGAAGCACTGCAGAGACATGGAAGAGGCGAGC CAGCGCAAGTGGAATTTCGATTTTCAGAATCACAAACCCCTAGAGGGCAAGTACGAGTGGCAAGAGGTGGAGAAGGGCAG CTTGCCCGAGTTCTACTACAGACCCCCGCGGCCCCCCAAAGGTGCCTGCAAGGTGCCGGCGCAGGAGAGCCAGGATGTCA GCGGGAGCCGCCCGGCGGCGCCTTTAATTGGGGCTCCGGCTAACTCTGAGGACACGCATTTGGTGGACCCAAAGACTGAT CCGTCGGACAGCCAGACGGGGTTAGCGGAGCAATGCGCAGGAATAAGGAAGCGACCTGCAACCGACG

CDKN1B - Exon 2

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Exon number	2
Length	130 nt
Location	Chromosome 12 (NC_000012.11) : 12871758...12871887 (+)
Is part of	CDKN1B, mRNA isoform 1 (NM_004064.3)
Sequence	Show
	ATTCTTCTACTCAAAACAAAAGAGCCAACAGAACAGAAGAAAATGTTTCAGACGGTTCCCCAAATGCCGGTTCTGTGGAG CAGACGCCCAAGAAGCCTGGCCTCAGAAGACGTCAAACGTAAACAGCTCG

CDKN1B - Exon 3

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Exon number	3
Length	1336 nt
Location	Chromosome 12 (NC_000012.11) : 12873969...12875304 (+)
Is part of	CDKN1B, mRNA isoform 1 (NM_004064.3)
Sequence	Show
	AATTAAGAATATGTTTCCTTGTTTATCAGATACATCACTGCTTGATGAAGCAAGGAAGATATACATGAAAATTTTAAAAA TACATATCGCTGACTTCATGGAATGGACATCCTGTATAAGCACTGAAAAACAACAACACAATAACACTAAAATTTTAGGC ACTCTTAAATGATCTGCCTCTAAAAGCGTTGGATGTAGCATTATGCAATTAGGTTTTTCCTTATTTGCTTCATTGTACTA CCTGTGTATATAGTTTTTACCTTTTATGTAGCACATAAACTTTGGGGAAGGGAGGGCAGGGTGGGGCTGAGGAACTGACG TGGAGCGGGGTATGAAGAGCTTGCTTTGATTTACAGCAAGTAGATAAATATTTGACTTGCATGAAGAGAAGCAATTTTGG GGAAGGGTTTGAATTGTTTTCTTTAAAGATGTAATGTCCCTTTCAGAGACAGCTGATACTTCATTTAAAAAAATCACAAA AATTTGAACACTGGCTAAAGATAATTGCTATTTATTTTTACAAGAAGTTTATTCTCATTTGGGAGATCTGGTGATCTCCC AAGCTATCTAAAGTTTGTTAGATAGCTGCATGTGGCTTTTTTAAAAAAGCAACAGAAACCTATCCTCACTGCCCTCCCCA GTCTCTCTTAAAGTTGGAATTTACCAGTTAATTACTCAGCAGAATGGTGATCACTCCAGGTAGTTTGGGGCAAAAATCCG AGGTGCTTGGGAGTTTTGAATGTTAAGAATTGACCATCTGCTTTTATTAAATTTGTTGACAAAATTTTCTCATTTTCTTT TCACTTCGGGCTGTGTAAACACAGTCAAAATAATTCTAAATCCCTCGATATTTTTAAAGATCTGTAAGTAACTTCACATT AAAAAATGAAATATTTTTTAATTTAAAGCTTACTCTGTCCATTTATCCACAGGAAAGTGTTATTTTTCAAGGAAGGTTCA TGTAGAGAAAAGCACACTTGTAGGATAAGTGAAATGGATACTACATCTTTAAACAGTATTTCATTGCCTGTGTATGGAAA AACCATTTGAAGTGTACCTGTGTACATAACTCTGTAAAAACACTGAAAAATTATACTAACTTATTTATGTTAAAAGATTT TTTTTAATCTAGACAATATACAAGCCAAAGTGGCATGTTTTGTGCATTTGTAAATGCTGTGTTGGGTAGAATAGGTTTTC CCCTCTTTTGTTAAATAATATGGCTATGCTTAAAAGGTTGCATACTGAGCCAAGTATAATTTTTTGTAATGTGTGAAAAA GATGCCAATTATTGTTACACATTAAGTAATCAATAAAGAAAACTTCCATAGCTATT

P46527 - Generality

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Primary source	Uniprot : P46527
Name	Cyclin-dependent kinase inhibitor 1B
Alternative name(s)	Cyclin-dependent kinase inhibitor p27 p27Kip1
Synonym(s)
Organism	Homo sapiens
Length	198 aa
Protein existence	---

External Links

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ArrayExpress	P46527
Refseq	NP_004055.1
Uniprot	P46527
EBI	EBI-519280
InterPro	IPR015456 IPR003175
KEGG	hsa:1027
PDB	2AST 1JSU 1H27
PDBsum	2AST 1JSU 1H27
Pfam	PF02234

General annotation (Comments)

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Disease	Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:610755]. Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.
Domain	A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity.
Function	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.
Induction	Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen stimulation as cells progress toward S-phase.
Ptm	Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF. Ubiquitinated; in the cytoplasm by the KPC1/KPC2 complex and, in the nucleus, by SCF/SKP2. The latter requires prior phosphorylation on Thr-187.
Similarity	Belongs to the CDI family.
Subcellular location	Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser- 10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89.
Subunit	Interacts with NUP50; the interaction leads to nuclear import and degradation of phosphorylated p27kip1. Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to p27KIP degradation. Interacts with SPDYA in the SPDYA/CDK2/p27kip1 complex. Interacts (Thr-198 phosphorylated- form) with 14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ results in translocation to the cytoplasm. Interacts with AKT1, LYN and UHMK1; the interactions lead to cytoplasmic mislocation, phosphorylation of p27kip1 and inhibition of cell cycle arrest. Interacts (unphosphorylated form) with CDK2. Interacts (phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction induces nuclear translocation. Interacts with GRB2. Interacts with PIM1.
Tissue specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Ontologies

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Biological process	regulation of cyclin-dependent protein kinase activity [GO:0000079] G1/S transition of mitotic cell cycle [GO:0000082] induction of apoptosis [GO:0006917] cell cycle arrest [GO:0007050] negative regulation of cell proliferation [GO:0008285] negative regulation of cell growth [GO:0030308] negative regulation of gene-specific transcription [GO:0032582] negative regulation of kinase activity [GO:0033673] negative regulation of phosphorylation [GO:0042326] autophagic cell death [GO:0048102]
Cellular component	nucleus [GO:0005634] cytosol [GO:0005829]
Molecular function	cyclin-dependent protein kinase inhibitor activity [GO:0004861] transforming growth factor beta receptor, cytoplasmic mediator activity [GO:0005072] protein binding [GO:0005515]

Binary interactions

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With	Uniprot accession	IntAct
YWHAE	P62258	EBI-519280,EBI-356498
Abl1 (xeno)	P00520	EBI-519280,EBI-914519
KPNA3	O00505	EBI-519280,EBI-358297
CCNB1	P14635	EBI-519280,EBI-495332
CKS1B	P61024	EBI-519280,EBI-456371
STMN1	P16949	EBI-519280,EBI-445909
UBA1	P22314	EBI-519280,EBI-709688
LYN	P07948	EBI-519280,EBI-79452
UCHL1	P09936	EBI-519280,EBI-714860
RBX1	P62877	EBI-519280,EBI-398523
CDK4	P11802	EBI-519280,EBI-295644
COPS5	Q92905	EBI-519280,EBI-594661
SKP2	Q13309	EBI-519280,EBI-456291
CCNA2	P20248	EBI-519280,EBI-457097
UBE2D2	P62837	EBI-519280,EBI-347677
TRAF2	Q12933	EBI-519280,EBI-355744
CCND1	P24385	EBI-519280,EBI-375001
RAN	P62826	EBI-519280,EBI-286642
YWHAG	P61981	EBI-519280,
CCNE2	O96020	EBI-519280,EBI-375033
CCNA1	P78396	EBI-519280,EBI-375065
CDK2	P24941	EBI-519280,EBI-375096
CUL1	Q13616	EBI-519280,EBI-359390
CDK5	Q00535	EBI-519280,EBI-1041567
SRC	P12931	EBI-519280,EBI-621482
KPNA5	O15131	EBI-519280,EBI-540602
???	P70168	EBI-519280,EBI-540580
NUTF2	P61970	EBI-519280,EBI-591778
YWHAB	P31946	EBI-519280,EBI-359815
CCNE1	P24864	EBI-519280,EBI-519526
YES1	P07947	EBI-519280,EBI-515331

Alternative product(s)

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Sequence annotation

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Feature key	Position	Length	Description	Feature identifier
Region
Motif	153 - 169	17	Nuclear localization signal (Potential)	P46527-MOTIF-153
Natural variations
Natural variant site	15 - 15	1	R -> W (in dbSNP:rs2066828)	VAR_011871
Natural variant site	109 - 109	1	V -> G (in dbSNP:rs2066827)	VAR_011872
Amino acid modifications
Modified residue	10 - 10	1	Phosphoserine; by UHMK1	P46527-MOD_RES-10
Modified residue	74 - 74	1	Phosphotyrosine; by SRC	P46527-MOD_RES-74
Modified residue	88 - 88	1	Phosphotyrosine; by ABL, LYN and SRC	P46527-MOD_RES-88
Modified residue	89 - 89	1	Phosphotyrosine	P46527-MOD_RES-89
Modified residue	140 - 140	1	Phosphoserine	P46527-MOD_RES-140
Modified residue	157 - 157	1	Phosphothreonine; by PKB/AKT1 and PIM1	P46527-MOD_RES-157
Modified residue	187 - 187	1	Phosphothreonine; by PKB/AKT1 and CDK2	P46527-MOD_RES-187
Modified residue	198 - 198	1	Phosphothreonine; by PKB/AKT1; RPS6KA4; RPS6KA5 and PIM1	P46527-MOD_RES-198
Experimental info
Mutagenesis	10 - 10	1	S->E: Increased stability in vivo and in vitro	P46527-MUTAGEN-10
Mutagenesis	74 - 74	1	Y->F: No change in binding CDK4. Translocates to nucleus	P46527-MUTAGEN-74
Mutagenesis	88 - 88	1	Y->F: Abolishes LYN-mediated phosphorylation. Reduced CDK2 phosphorylation on T-187. Greater cell cycle arrest into S-phase. No effect on binding CDK2 complexes. Reduction of CDK4 binding. No nuclear translocation. Completely abolishes CDK4 binding; when associated with F-89	P46527-MUTAGEN-88
Mutagenesis	89 - 89	1	Y->F: No effect on binding CDK2 complexes. Reduction of CDK4 binding. No nuclear translocation. Completely abolishes CDK4 binding; when associated with F-88	P46527-MUTAGEN-89
Mutagenesis	157 - 157	1	T->A: Greatly reduced PKB/AKT1-mediated phosphorylation. Nuclear location. Inhibits cyclin E/CDK2 cell cycle progression. No effect on binding AKT1. Completely abolishes PKB/AKT1-mediated phosphorylation and no cytoplasmic translocation; when associated with A- 198	P46527-MUTAGEN-157
Mutagenesis	161 - 161	1	S->A: No change in PKB/AKT1-mediated phosphorylation	P46527-MUTAGEN-161
Mutagenesis	162 - 162	1	T->A: No change in PKB/AKT1-mediated phosphorylation	P46527-MUTAGEN-162
Mutagenesis	187 - 187	1	T->A,D: No change in PKB/AKT1- nor UHMK1- mediated phosphorylation	P46527-MUTAGEN-187
Mutagenesis	198 - 198	1	T->A,D: Abolishes PKB/AKT1-mediated phosphorylation. 46% cytoplasmic location. Greatly reduced binding to YWHAQ. Equally reduced binding; when associated with A-10 and A-187. No nuclear import; when associated with A- 157. Completely abolishes PKB/AKT1- mediated phosphorylation and no cytoplasmic translocation; when associated with A-157	P46527-MUTAGEN-198

Sequence

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	FASTA

1	MSNVRVSNGS	PSLERMDARQ	AEHPKPSACR	NLFGPVDHEE	LTRDLEKHCR	DMEEASQRKW	NFDFQNHKPL	EGKYEWQEVE
81	KGSLPEFYYR	PPRPPKGACK	VPAQESQDVS	GSRPAAPLIG	APANSEDTHL	VDPKTDPSDS	QTGLAEQCAG	IRKRPATDDS
161	STQNKRANRT	EENVSDGSPN	AGSVEQTPKK	PGLRRRQT

Q6I9V6 - Generality

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Primary source	Uniprot : Q6I9V6
Name	CDKN1B protein [submitted name]
Alternative name(s)	Cyclin-dependent kinase inhibitor 1B (P27, Kip1), isoform CRA_a [submitted name] Cyclin-dependent kinase inhibitor 1B [submitted name] cDNA, FLJ92816, Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1)(CDKN1B), mRNA [submitted name]
Synonym(s)
Organism	Homo sapiens
Length	198 aa
Protein existence	---

External Links

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ArrayExpress	Q6I9V6
Refseq	NP_004055.1
Uniprot	Q6I9V6
InterPro	IPR015456 IPR003175
KEGG	hsa:1027
Pfam	PF02234

General annotation (Comments)

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Ontologies

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Biological process	cell cycle arrest [GO:0007050]
Cellular component	nucleus [GO:0005634]
Molecular function	cyclin-dependent protein kinase inhibitor activity [GO:0004861] kinase activity [GO:0016301]

Binary interactions

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With	Uniprot accession	IntAct

Alternative product(s)

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Sequence annotation

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Feature key	Position	Length	Description	Feature identifier

Sequence

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	FASTA

1	MSNVRVSNGS	PSLERMDARQ	AEHPKPSACR	NLFGPVDHEE	LTRDLEKHCR	DMEEASQRKW	NFDFQNHKPL	EGKYEWQEVE
81	KGSLPEFYYR	PPRPPKGACK	VPAQESQDVS	GSRPAAPLIG	APANSEDTHL	VDPKTDPSDS	QTGLAEQCAG	IRKRPATDDS
161	STQNKRANRT	EENVSDGSPN	AGSVEQTPKK	PGLRRRQT