(RGS19) regulator of G-protein signaling 19 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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10541
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Official symbol
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RGS19
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Official name
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regulator of G-protein signaling 19
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 20 (NC_000020.10) : 62704533...62711323 (-)
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Map
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20q13.33
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Length
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6791 nt
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NM_005873.2
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RGS19, mRNA isoform 1
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NM_001039467.1
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RGS19, mRNA isoform 2
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Accession
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Name
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Organism
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Length
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P49795
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Regulator of G-protein signaling 19
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Homo sapiens
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217 aa
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Synonyms |
RGSGAIP; GAIP
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Alternative name(s) |
guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; G alpha interacting protein; regulator of G-protein signalling 19
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Summary |
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
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Related Articles in PubMed
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Go to ensembl
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1 |
GCCTGCGCAC |
TGCGCCCCCG |
CGCCCCCTCC |
CCGACTGTCG |
GGCCGGACCT |
TGGAGCGCGC |
GGGCCGGCGG |
CGGCGCGAGT |
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81 |
GGCTCGGGAG |
CGCGGCTGGT |
GAGTGCGCGC |
GCGCAGCGCC |
GGGGACAGCG |
GCCCTGCCCC |
TCCCGGCCCG |
GGCCCGGGGA |
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161 |
CCGTGCTGGG |
CGGGAGCTTC |
GGGAGCCGGC |
GCACGGGACT |
CGAACCCCAA |
GGGCTCCCGC |
CGCCAGGTCC |
ACGTGGACCC |
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241 |
TGGGCCGCAG |
TGGAAGTGGA |
GCCCGCCCCC |
CGCGCGTGGG |
GGAGGGGGCG |
CCGCAGCCGG |
GTTCCCCTTT |
TTCTGGAGCT |
|
321 |
CAAAGCCTGG |
GGAAGTGATT |
GCTCAAAGGT |
GGGGGCCGGA |
AGAACCCAGG |
TTTCCGCGTC |
TCCCTCCCCC |
TCTCAGCCCG |
|
401 |
GTGAGGAGGG |
GCCGGGGCGG |
GACACCCTGT |
CCGCCCCCGC |
CCCCACCCCG |
CTGGATCTGG |
CAGCCACTCA |
GCCCTTCGAG |
|
481 |
CTGTAGGGGA |
GGCGCTGCGC |
CCCCGGCCCC |
AGCCGATCGG |
GGGCTCCTGG |
CGCTAGCCTC |
CCTCCAGAGC |
GCCGCAGGAG |
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561 |
TCCCTCCTGC |
CGTCTGACTT |
GAGTCCCTGC |
TGCTGCAGTG |
CACGCCCCTT |
CGGCAGCCAG |
GGTGGGGCCC |
AGACCCAACC |
|
641 |
TGGCCCCTCC |
TGCCCCCACC |
CCGCCTTTGG |
GTCGCTGGTG |
AGTAGGGAGC |
TTTGAGGTAG |
GGGTGGGGGC |
GTCAGAGGCT |
|
721 |
GAAGAAAGAG |
GCACCTGGAG |
GAGAACACAG |
GCTTCTCCAG |
ACTGGACCCT |
AACAGCAGAG |
AGAGGAGCGT |
GGTGGGTGGG |
|
801 |
CCACCACCAC |
CATTTCAGAG |
GTGGGGAGAG |
CTGGCCTTCC |
CTGGAGGGGC |
CAGGCCAGGG |
CTCGCCCACC |
AGCCAGATGT |
|
881 |
GGAGGGTGGC |
AGATGGGAAA |
GGCCCTGGGT |
AGGAGCTAAG |
GACTGAGAAT |
GGAGCCCCTC |
TTCAACCCCC |
CTCCCAAAGG |
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961 |
TTATGACATT |
TTTTTCTGGG |
ATTGTCACAT |
TTTCTTATTC |
TTTTTTTGGA |
CTGGGCAGGC |
TCTGGGACGT |
TCTTTTTCCT |
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1041 |
TCTGTGGAGC |
AAAGCGGCAG |
CCACTCCCAA |
GGGATCCTCT |
ATCCCCAGAG |
AGCAGACGTG |
CCGCCTATCC |
AGCCTATCCC |
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1121 |
ATCCCAGACT |
TGGGGGCCAA |
AGCCTGGGAG |
GCTGGGGAAG |
GGGGTCCCCA |
ATGCCAGGTT |
GACAAGCAGG |
AGGACCCTAG |
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1201 |
TTGAGACTCT |
GTATCCCCCA |
GGAGAGACGG |
GGGGAGGGTA |
GCCTGGGGAC |
ATGGGTTGCC |
CCAGTTGACC |
TGAGAAGGGT |
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1281 |
ACAGGAAGCC |
AGGTCCAGGG |
ACAGGTGACC |
AGGTCCAGGG |
CCTGCAACTG |
GGAAAGAAGG |
GGCTGGCTCC |
CTGCTCTGCA |
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1361 |
GCAAATGCAG |
CCCCTAGCAC |
CCCGGCCCTG |
CACCCCTAAA |
CACGTCCCCT |
CCTCCAGTTC |
AGAGCTGGGG |
TGGAGATGGT |
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1441 |
AGCCCAGGGG |
GACAGTCTCA |
GGGGTGCTAG |
AGTGTGGGGG |
AGGACCCTGG |
GTGGGGACAG |
AGAGGAGGAA |
GAACTGCTGC |
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1521 |
CTGGGGAAGC |
CACAGACAGC |
CCCGTCTGGG |
TACAGCTACC |
AAACCTCAGG |
TTGCCACGCC |
CCTTCCTTTC |
CCTAGAAACT |
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1601 |
TGACCCCTGA |
AAGAAAGCCC |
AGCTGCAGGG |
CTACTTTCGG |
TCTCCTCATC |
TACTTGCTAG |
GAGCCCGTGG |
GACCCCCAGT |
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1681 |
CTCAGAGGAA |
ACTGGGCCGG |
TGGTGAGGGG |
CCAAGGTCCC |
AGGGGATGCT |
GCACCTGCCC |
CAGACTTGGG |
CCAGGGCAGT |
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1761 |
GGCCTCTGCA |
TGCCCAGGCC |
TCGGGGGTAT |
TGGGGGCCCT |
AAGAGTGCAG |
AACTCCAGCA |
CTGTCTCTTC |
TGAGGGCCAT |
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1841 |
TCACACACCG |
TCCCAGGAGG |
CCAAGAGAAG |
CCAACCAGCC |
AGAAACAAGC |
ATTCAAAGGC |
CACGAGCTAG |
GGGAGGCGTG |
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1921 |
GCGGGGGGAT |
GAAGATTGAG |
AAAATAAAGT |
AGAATCAAGT |
TGTGAGCTTC |
CTGGCCAGGG |
AGGGTGGCGG |
CACATGAGGA |
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2001 |
GGGTGGCGGA |
TGTGCACGGA |
GGCCCCTCCC |
TGCCCTGGGC |
AGAAGTGGGC |
GCAGGTGTTC |
ACAACTGCCT |
CCGGGGCACT |
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2081 |
GATTGGCCCC |
CCTGTACCAT |
CGCCCAAGGA |
GACTTGGGAT |
TCGAAGTGGC |
ATCTTAGGTG |
GCATGAGGGC |
CACTCACAGC |
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2161 |
TTTGGCGCTC |
CTGGTGCACC |
TCCCCTGCAG |
ACGGTGCAAC |
CAAATGCTGG |
GAGGGACATG |
CACCACACCA |
CACCCCCCTC |
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2241 |
AGGGACTCCG |
AGGCTTCGAC |
TGGGGAGCAG |
GGTGCCCCCC |
ACCCCTGCCA |
CCCCCACTTC |
CCTGGCTGGC |
GCACCCTGTG |
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2321 |
GTAGGGCCTT |
GGTTCCACAG |
CAGTTTCACA |
GCCTAGAGGC |
AGTGGGCAAG |
GAGGGAGGGA |
AGTCTTGGGT |
GGGAGGTAGC |
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2401 |
AGGACCAAAG |
AACCATGTTT |
GGGGGGCATG |
TCCCTCCTCA |
CCGGGGCCCT |
GCCCCCCTTC |
CCACACCCTC |
AGCAAGTCCA |
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2481 |
GCCTGAGTCC |
CACTTAAATC |
CTCACTGCTG |
CAGGTCTAGC |
CTGCTGCCCC |
TGGCTGAGAC |
CTCTGGGACC |
CACAGACAGA |
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2561 |
CCTGGACTCT |
TGGTGGGAAG |
CCACTCTGCC |
CACTCCCCAC |
CCCAGACACC |
CTAGAAGCCA |
GTCTGGCCAC |
CACCCGCACG |
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2641 |
CACCAGTTGG |
TAGCCCCAGA |
CTCTCGGGGC |
CCCTTTGGGA |
GGGGCTGGGA |
GCCGGAAACC |
AAGAAAGAGG |
AACCCAGGCT |
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2721 |
TCCGGCTTCC |
CAGGGAGTGA |
GCGGATGGGG |
GTGTCTCGGA |
ACCTCCAGTG |
GGGGCCTCAT |
CTGGGGCCCA |
GCCTGGGAGG |
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2801 |
AGGGGCCAGA |
AGCTGCTGCA |
GCTCCCTCCT |
CAATGATCCT |
GGACCCCCTC |
CCAGCCCTGC |
TGTAAGCTTG |
GGGTCGGGGT |
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2881 |
AGAAGCCCTA |
GGCAGAGCTG |
GGTCCAGAGG |
CAGGAGCAGG |
CCCCGCTAGG |
GAGACACCCT |
CTCAGGACCC |
CTCCTAAGGG |
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2961 |
GTAGGCAGGG |
GCTGGGGTTT |
CAGGTTCTCA |
GTCAGAACCT |
TGGCCCCTCT |
CCCCAGACCC |
CCAGGCTGTG |
GTGAGGGTCT |
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3041 |
GAGAGCTGGT |
ACCACGGAGC |
CTGGGCAACC |
TCCTCCGCCC |
ACCCATGCCC |
ACCCCGCATG |
AGGCTGAGAA |
GCAGGTATGC |
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3121 |
CACCTCCCCC |
TCTGCCTCTG |
CTCCCCTGGG |
GGAGATGGGG |
TGGGGCAAGC |
TGAGGGGCCA |
CAAGGAGCTG |
GGAGATCCCT |
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3201 |
GAACACCCGG |
GAGGCCAGAA |
GGGTCATGTG |
CCTGGGAACA |
GGGCTACCCA |
TGGGAAGGTG |
GGGGAGAGGT |
GGAGAGTCTG |
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3281 |
GTGGGTTCTG |
ACCTGAAAGC |
TGAGGTAGCC |
CCACTTTTCC |
CCAGATCACA |
GGGCCAGAGG |
AGGCGGACCG |
GCCCCCTTCA |
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3361 |
ATGTCCAGTC |
ATGATACAGC |
CTCTCCAGCG |
GCCCCCAGCC |
GCAACCCCTG |
CTGCCTGTGC |
TGGTGCTGCT |
GCTGTAGCTG |
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3441 |
CTCCTGGTGA |
GTAGGGCCTG |
GGGTGCCCAG |
CTGGCGAGGG |
GGTCGAGGGC |
ATGGGGCCAA |
GCAGACCCAG |
GAGGGGACCC |
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3521 |
AGTGGTGGCT |
TCCGAGGCAT |
CCCCGCAGGC |
AGGATGCCCC |
TGCCACCTCA |
CAGCACTGTC |
CTGTCCAGGG |
TCTGTTGGGC |
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3601 |
CCTGGTGATG |
AGTGGCCGGT |
GCCTTGGCCC |
CAGGGAGCTC |
ATGTATGGCT |
CTCGTACCTG |
TCTTGCCAAG |
GGTGTGTCCG |
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3681 |
TGTGCTGTGT |
ACATGCATGT |
GCCCGTTCAC |
GCGGCATGTG |
CTTTATCCAT |
GCTGCTGTGA |
GCCAGCCCAG |
GCTAGGCCCT |
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3761 |
GGGGGCCTGC |
GGTGGAGTAA |
GACAGGCACA |
GGCCAGGTGC |
AGTGGCTCAT |
GCCTGTAGTC |
CCAGCACTTT |
GGGAGGGCAA |
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3841 |
GGTGGGCGGA |
TCACCTGAGG |
TCGGGAGTTC |
GAGATCAGCC |
TGACCAATGT |
GCAGAAACCC |
TGTCTCTACT |
AAAAATACAA |
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3921 |
AATTAGCCAG |
GCGTGGTGGC |
GCATGCCTGT |
AATCCCAGCT |
ACTCGGGAGG |
CTGAGGCAGG |
AGAATGGCTT |
GAACCTGGGA |
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4001 |
GGCGGAGGTT |
GCGTTGAGCC |
GAGATCGCGT |
CATTGCACTC |
CAGCCTGGGC |
AACAAGAGCA |
AAACTCCGTC |
TCAAAAAAAA |
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4081 |
AAAAAGAAAG |
AAAGAAAGAA |
AGACAGGCAC |
AGACCCCATA |
CAGTGTGTGG |
GGTGGAGGGA |
CGTTTGAACA |
GAGACCCCAA |
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4161 |
TAAGGGAACT |
GCTGGCCCTG |
GGGCGATGGC |
CAAGAGCTTC |
CCGGACAGCA |
TGCGTGGGGG |
AAGAAGAGCA |
GGGGGCGGTG |
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4241 |
GCGGGGACGT |
CTCTGGGCAT |
CCCTGTGAGG |
GTGGGAGTGG |
GGCTCCCAGA |
TGGTAACAGA |
TTTCCTAGGA |
GTGTAGGGGA |
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4321 |
GCTGGTGGAT |
GTTTTCACAC |
CTTGCAGAAG |
CCTGGCCCTA |
TTCAGGCTTC |
AGGCCCTGGC |
TGATGAGAGG |
ACAGCGCTTC |
|
4401 |
TGGATCCAAG |
GTGGCGTCAG |
CTGACCCACG |
GGCAAGCTGG |
GGGTGGCCAG |
GGGGCAGTCG |
GGAAAGGGGG |
TGGGAGGAGC |
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4481 |
CCAGGGGCCT |
AGTTCTGTCA |
GGACGTTTGG |
GTGCACGATG |
TCTGCCAGCC |
ATCCAAGTGC |
CCTGGAGAGA |
GGTCAGCCGG |
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4561 |
GTATGGATTT |
GGGTCCAGCA |
CTGACAGGAT |
GCTAGGAGCC |
AAGGCAAAGA |
AGCTGCTTCC |
CTTGAGACAA |
CCGGGGATCA |
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4641 |
GGCTCCAGAA |
CCTGAAGGAG |
TGTGGACACG |
GGTTTGGGGC |
TCTCACCTGC |
GTCAGCCGAC |
GAGAGACACT |
GCTGACACGC |
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4721 |
CAGACCTGCA |
GCGTGTGACC |
CCATCGGTGG |
GACAGGGACA |
GGCCAAGATC |
AGGCCCAGGA |
GCAGGGTGGC |
CCTGTTCCCA |
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4801 |
GGCACATTCC |
CATGGGTGGC |
CCTGTTCCCA |
GGCACATTCC |
CATGGGTGGC |
CCTGTTCCCA |
GGCACATTCC |
CATGGGTGGC |
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4881 |
CCTGTTCCCA |
GGCACATGAC |
CCTTCTGGCC |
TCCCAGGTGT |
TCAGGGATCT |
CCCAGCTCCT |
TGTGGCCCCT |
CATCTTGCCC |
|
4961 |
CACCCCATCT |
CCCCCAGGGG |
AGCAGAGGCA |
GAAGGGGAGG |
TGGCATACCT |
GCTTCTCAAC |
CTCATGTGGG |
GTGGGCATGG |
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5041 |
GTGGGTGGAG |
GAGGTTGCCC |
AGTGGGCCAG |
GGATGGGGAG |
GAGCACACCA |
GGAGCCGAAG |
GGCCCCTCCT |
GGAAGGCCAG |
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5121 |
AGACTCGCGG |
GCACTGGGTC |
ACACTGCTGG |
AATGGAAGAC |
GGCAGAGTCT |
GTGGTCTGGG |
CACTGTGGCA |
GGGACAGTAA |
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5201 |
CCTGGACTGC |
AGATTCTGTG |
GGGAATTTGG |
GAGTGTGGGA |
GAGTGTGGGA |
AGAGCCAGCT |
CCAGGGGCTG |
CCCTCCTGCA |
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5281 |
GTGGGTGCCC |
ATGTGTGTCA |
GGTGCCTGCA |
GGGGCTGCCC |
TCCTGCAGTG |
GGTGCCCATG |
TGTGTCAGGT |
GCCTGCCCAT |
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5361 |
GTGCTGAGGG |
CCTGTGTGGC |
CGTGGAGGCG |
TGTGTGCCCA |
CGGCAGCGCT |
GCTTCCTCTC |
TGCCACTAGG |
AACCAAGAGC |
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5441 |
GGCGGCGCGC |
GTGGCAGGCC |
TCCCGGGAGA |
GCAAGCTGCA |
GCCCCTCCCC |
AGCTGTGAAG |
TATGGTGAGT |
CCAGCCGGCT |
|
5521 |
GGTGTGTGCG |
TGCTGGGGGG |
GCCCCAGACC |
GGGAGACTCG |
GGCCTGACAT |
AGCCTGGCCC |
CCGTGCCCAC |
AGTGCCACGC |
|
5601 |
CAAGTCCTGA |
GGAGGTGCAG |
AGCTGGGCGC |
AGTCTTTTGA |
CAAGCTGATG |
CACAGCCCAG |
CGGGACGCAG |
CGTGTTCCGG |
|
5681 |
GCGTTCCTGC |
GGACAGAGTA |
CAGCGAGGAG |
AACATGCTCT |
TCTGGTTGGC |
CTGCGAGGAG |
CTGAAGGCCG |
AGGCCAACCA |
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5761 |
GCATGTGGTA |
GACGAGAAGG |
CGAGGCTCAT |
CTACGAGGAC |
TACGTATCCA |
TCCTGTCCCC |
CAAGGAGGTG |
CGCCAGACAC |
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5841 |
CAGAACAGGC |
CGGGGGCCGC |
CTGCTCCAGG |
CACTAGGTGG |
GGAAGGCAGC |
TCCCGCACCC |
CCTGACCTCA |
GTGTCTTGTC |
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5921 |
CTGCAGGTGA |
GCCTGGACTC |
CCGTGTGCGG |
GAGGGCATCA |
ACAAGAAGAT |
GCAGGAGCCG |
TCCGCACACA |
CGTTCGACGA |
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6001 |
CGCGCAGCTG |
CAGATCTACA |
CGCTCATGCA |
CCGGGACTCC |
TACCCCCGCT |
TCCTCAGCTC |
TCCCACCTAC |
CGTGCCCTGC |
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6081 |
TGCTGCAGGG |
GCCATCACAG |
TCCTCCTCCG |
AGGCCTAGGC |
CGCCCCCAGC |
AGCACAGACC |
CCGCCGCCTC |
CTACGGCCGA |
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6161 |
CTCTGGGTTC |
CCTTCAGGTG |
TTGTTGTCGG |
CAGGGCTGTC |
AGGGCACATG |
CCTGGCCGGC |
TGGGGTCCCC |
ACCCGCGGAG |
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6241 |
ACGGTCCTAG |
ACCCAGTGGG |
GAGTGCTGTG |
TCTCCTGGGT |
CTGCCCACCC |
GTGGCCAAGC |
AGGAACTCCA |
GGTGCAGGGC |
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6321 |
GGGCCTCCAG |
GTGCAGGGCG |
GGCCAGAAGC |
CCCCTCATCG |
GCCCGCAGCT |
GGCTGGCCCA |
GTGCTCCTGG |
CTGGGGGCTC |
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6401 |
TTGCGTGGTG |
AGAGTAGGGG |
TCCCCCCAGG |
AGCCATGCTG |
GACCCATGAG |
CCTCGCTGGG |
GCCTCCTCCC |
CAGGCAGCCA |
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6481 |
ATGGGCCCCA |
GACAAGCCTT |
TGGTGGGGAA |
CAGAACCTCC |
GCATCGTGTA |
GTTTTGTGAC |
ATAAGGAGAC |
CTCCTACTTG |
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6561 |
AGCTGTCTGT |
ACCCCAGAAT |
CAAACACAGA |
ACCTCAGAAC |
CAGATTTAGG |
ACCTCAGAAT |
CCTGCACTCA |
AGGTGGCAGG |
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6641 |
ACCCAATTTC |
TGTTTTATAT |
GTTCATGAAC |
TTTAAACCTG |
GAAACATGTC |
CTTACTAGGT |
GTTTTATCAA |
AAAAAAGTTT |
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6721 |
TCATATTTAT |
CTCTATCCCT |
AACCCCCCAA |
AAATAGGATG |
TCTTATTATT |
GAAGATATTT |
TTAAAGCAAA |
G |
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>ref|Gene_ID:10287|RGS19|NC_000020.10:62704533...62711323 (-)
GCCTGCGCACTGCGCCCCCGCGCCCCCTCCCCGACTGTCGGGCCGGACCTTGGAGCGCGCGGGCCGGCGGCGGCGCGAGT
GGCTCGGGAGCGCGGCTGGTGAGTGCGCGCGCGCAGCGCCGGGGACAGCGGCCCTGCCCCTCCCGGCCCGGGCCCGGGGA
CCGTGCTGGGCGGGAGCTTCGGGAGCCGGCGCACGGGACTCGAACCCCAAGGGCTCCCGCCGCCAGGTCCACGTGGACCC
TGGGCCGCAGTGGAAGTGGAGCCCGCCCCCCGCGCGTGGGGGAGGGGGCGCCGCAGCCGGGTTCCCCTTTTTCTGGAGCT
CAAAGCCTGGGGAAGTGATTGCTCAAAGGTGGGGGCCGGAAGAACCCAGGTTTCCGCGTCTCCCTCCCCCTCTCAGCCCG
GTGAGGAGGGGCCGGGGCGGGACACCCTGTCCGCCCCCGCCCCCACCCCGCTGGATCTGGCAGCCACTCAGCCCTTCGAG
CTGTAGGGGAGGCGCTGCGCCCCCGGCCCCAGCCGATCGGGGGCTCCTGGCGCTAGCCTCCCTCCAGAGCGCCGCAGGAG
TCCCTCCTGCCGTCTGACTTGAGTCCCTGCTGCTGCAGTGCACGCCCCTTCGGCAGCCAGGGTGGGGCCCAGACCCAACC
TGGCCCCTCCTGCCCCCACCCCGCCTTTGGGTCGCTGGTGAGTAGGGAGCTTTGAGGTAGGGGTGGGGGCGTCAGAGGCT
GAAGAAAGAGGCACCTGGAGGAGAACACAGGCTTCTCCAGACTGGACCCTAACAGCAGAGAGAGGAGCGTGGTGGGTGGG
CCACCACCACCATTTCAGAGGTGGGGAGAGCTGGCCTTCCCTGGAGGGGCCAGGCCAGGGCTCGCCCACCAGCCAGATGT
GGAGGGTGGCAGATGGGAAAGGCCCTGGGTAGGAGCTAAGGACTGAGAATGGAGCCCCTCTTCAACCCCCCTCCCAAAGG
TTATGACATTTTTTTCTGGGATTGTCACATTTTCTTATTCTTTTTTTGGACTGGGCAGGCTCTGGGACGTTCTTTTTCCT
TCTGTGGAGCAAAGCGGCAGCCACTCCCAAGGGATCCTCTATCCCCAGAGAGCAGACGTGCCGCCTATCCAGCCTATCCC
ATCCCAGACTTGGGGGCCAAAGCCTGGGAGGCTGGGGAAGGGGGTCCCCAATGCCAGGTTGACAAGCAGGAGGACCCTAG
TTGAGACTCTGTATCCCCCAGGAGAGACGGGGGGAGGGTAGCCTGGGGACATGGGTTGCCCCAGTTGACCTGAGAAGGGT
ACAGGAAGCCAGGTCCAGGGACAGGTGACCAGGTCCAGGGCCTGCAACTGGGAAAGAAGGGGCTGGCTCCCTGCTCTGCA
GCAAATGCAGCCCCTAGCACCCCGGCCCTGCACCCCTAAACACGTCCCCTCCTCCAGTTCAGAGCTGGGGTGGAGATGGT
AGCCCAGGGGGACAGTCTCAGGGGTGCTAGAGTGTGGGGGAGGACCCTGGGTGGGGACAGAGAGGAGGAAGAACTGCTGC
CTGGGGAAGCCACAGACAGCCCCGTCTGGGTACAGCTACCAAACCTCAGGTTGCCACGCCCCTTCCTTTCCCTAGAAACT
TGACCCCTGAAAGAAAGCCCAGCTGCAGGGCTACTTTCGGTCTCCTCATCTACTTGCTAGGAGCCCGTGGGACCCCCAGT
CTCAGAGGAAACTGGGCCGGTGGTGAGGGGCCAAGGTCCCAGGGGATGCTGCACCTGCCCCAGACTTGGGCCAGGGCAGT
GGCCTCTGCATGCCCAGGCCTCGGGGGTATTGGGGGCCCTAAGAGTGCAGAACTCCAGCACTGTCTCTTCTGAGGGCCAT
TCACACACCGTCCCAGGAGGCCAAGAGAAGCCAACCAGCCAGAAACAAGCATTCAAAGGCCACGAGCTAGGGGAGGCGTG
GCGGGGGGATGAAGATTGAGAAAATAAAGTAGAATCAAGTTGTGAGCTTCCTGGCCAGGGAGGGTGGCGGCACATGAGGA
GGGTGGCGGATGTGCACGGAGGCCCCTCCCTGCCCTGGGCAGAAGTGGGCGCAGGTGTTCACAACTGCCTCCGGGGCACT
GATTGGCCCCCCTGTACCATCGCCCAAGGAGACTTGGGATTCGAAGTGGCATCTTAGGTGGCATGAGGGCCACTCACAGC
TTTGGCGCTCCTGGTGCACCTCCCCTGCAGACGGTGCAACCAAATGCTGGGAGGGACATGCACCACACCACACCCCCCTC
AGGGACTCCGAGGCTTCGACTGGGGAGCAGGGTGCCCCCCACCCCTGCCACCCCCACTTCCCTGGCTGGCGCACCCTGTG
GTAGGGCCTTGGTTCCACAGCAGTTTCACAGCCTAGAGGCAGTGGGCAAGGAGGGAGGGAAGTCTTGGGTGGGAGGTAGC
AGGACCAAAGAACCATGTTTGGGGGGCATGTCCCTCCTCACCGGGGCCCTGCCCCCCTTCCCACACCCTCAGCAAGTCCA
GCCTGAGTCCCACTTAAATCCTCACTGCTGCAGGTCTAGCCTGCTGCCCCTGGCTGAGACCTCTGGGACCCACAGACAGA
CCTGGACTCTTGGTGGGAAGCCACTCTGCCCACTCCCCACCCCAGACACCCTAGAAGCCAGTCTGGCCACCACCCGCACG
CACCAGTTGGTAGCCCCAGACTCTCGGGGCCCCTTTGGGAGGGGCTGGGAGCCGGAAACCAAGAAAGAGGAACCCAGGCT
TCCGGCTTCCCAGGGAGTGAGCGGATGGGGGTGTCTCGGAACCTCCAGTGGGGGCCTCATCTGGGGCCCAGCCTGGGAGG
AGGGGCCAGAAGCTGCTGCAGCTCCCTCCTCAATGATCCTGGACCCCCTCCCAGCCCTGCTGTAAGCTTGGGGTCGGGGT
AGAAGCCCTAGGCAGAGCTGGGTCCAGAGGCAGGAGCAGGCCCCGCTAGGGAGACACCCTCTCAGGACCCCTCCTAAGGG
GTAGGCAGGGGCTGGGGTTTCAGGTTCTCAGTCAGAACCTTGGCCCCTCTCCCCAGACCCCCAGGCTGTGGTGAGGGTCT
GAGAGCTGGTACCACGGAGCCTGGGCAACCTCCTCCGCCCACCCATGCCCACCCCGCATGAGGCTGAGAAGCAGGTATGC
CACCTCCCCCTCTGCCTCTGCTCCCCTGGGGGAGATGGGGTGGGGCAAGCTGAGGGGCCACAAGGAGCTGGGAGATCCCT
GAACACCCGGGAGGCCAGAAGGGTCATGTGCCTGGGAACAGGGCTACCCATGGGAAGGTGGGGGAGAGGTGGAGAGTCTG
GTGGGTTCTGACCTGAAAGCTGAGGTAGCCCCACTTTTCCCCAGATCACAGGGCCAGAGGAGGCGGACCGGCCCCCTTCA
ATGTCCAGTCATGATACAGCCTCTCCAGCGGCCCCCAGCCGCAACCCCTGCTGCCTGTGCTGGTGCTGCTGCTGTAGCTG
CTCCTGGTGAGTAGGGCCTGGGGTGCCCAGCTGGCGAGGGGGTCGAGGGCATGGGGCCAAGCAGACCCAGGAGGGGACCC
AGTGGTGGCTTCCGAGGCATCCCCGCAGGCAGGATGCCCCTGCCACCTCACAGCACTGTCCTGTCCAGGGTCTGTTGGGC
CCTGGTGATGAGTGGCCGGTGCCTTGGCCCCAGGGAGCTCATGTATGGCTCTCGTACCTGTCTTGCCAAGGGTGTGTCCG
TGTGCTGTGTACATGCATGTGCCCGTTCACGCGGCATGTGCTTTATCCATGCTGCTGTGAGCCAGCCCAGGCTAGGCCCT
GGGGGCCTGCGGTGGAGTAAGACAGGCACAGGCCAGGTGCAGTGGCTCATGCCTGTAGTCCCAGCACTTTGGGAGGGCAA
GGTGGGCGGATCACCTGAGGTCGGGAGTTCGAGATCAGCCTGACCAATGTGCAGAAACCCTGTCTCTACTAAAAATACAA
AATTAGCCAGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGA
GGCGGAGGTTGCGTTGAGCCGAGATCGCGTCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCCGTCTCAAAAAAAA
AAAAAGAAAGAAAGAAAGAAAGACAGGCACAGACCCCATACAGTGTGTGGGGTGGAGGGACGTTTGAACAGAGACCCCAA
TAAGGGAACTGCTGGCCCTGGGGCGATGGCCAAGAGCTTCCCGGACAGCATGCGTGGGGGAAGAAGAGCAGGGGGCGGTG
GCGGGGACGTCTCTGGGCATCCCTGTGAGGGTGGGAGTGGGGCTCCCAGATGGTAACAGATTTCCTAGGAGTGTAGGGGA
GCTGGTGGATGTTTTCACACCTTGCAGAAGCCTGGCCCTATTCAGGCTTCAGGCCCTGGCTGATGAGAGGACAGCGCTTC
TGGATCCAAGGTGGCGTCAGCTGACCCACGGGCAAGCTGGGGGTGGCCAGGGGGCAGTCGGGAAAGGGGGTGGGAGGAGC
CCAGGGGCCTAGTTCTGTCAGGACGTTTGGGTGCACGATGTCTGCCAGCCATCCAAGTGCCCTGGAGAGAGGTCAGCCGG
GTATGGATTTGGGTCCAGCACTGACAGGATGCTAGGAGCCAAGGCAAAGAAGCTGCTTCCCTTGAGACAACCGGGGATCA
GGCTCCAGAACCTGAAGGAGTGTGGACACGGGTTTGGGGCTCTCACCTGCGTCAGCCGACGAGAGACACTGCTGACACGC
CAGACCTGCAGCGTGTGACCCCATCGGTGGGACAGGGACAGGCCAAGATCAGGCCCAGGAGCAGGGTGGCCCTGTTCCCA
GGCACATTCCCATGGGTGGCCCTGTTCCCAGGCACATTCCCATGGGTGGCCCTGTTCCCAGGCACATTCCCATGGGTGGC
CCTGTTCCCAGGCACATGACCCTTCTGGCCTCCCAGGTGTTCAGGGATCTCCCAGCTCCTTGTGGCCCCTCATCTTGCCC
CACCCCATCTCCCCCAGGGGAGCAGAGGCAGAAGGGGAGGTGGCATACCTGCTTCTCAACCTCATGTGGGGTGGGCATGG
GTGGGTGGAGGAGGTTGCCCAGTGGGCCAGGGATGGGGAGGAGCACACCAGGAGCCGAAGGGCCCCTCCTGGAAGGCCAG
AGACTCGCGGGCACTGGGTCACACTGCTGGAATGGAAGACGGCAGAGTCTGTGGTCTGGGCACTGTGGCAGGGACAGTAA
CCTGGACTGCAGATTCTGTGGGGAATTTGGGAGTGTGGGAGAGTGTGGGAAGAGCCAGCTCCAGGGGCTGCCCTCCTGCA
GTGGGTGCCCATGTGTGTCAGGTGCCTGCAGGGGCTGCCCTCCTGCAGTGGGTGCCCATGTGTGTCAGGTGCCTGCCCAT
GTGCTGAGGGCCTGTGTGGCCGTGGAGGCGTGTGTGCCCACGGCAGCGCTGCTTCCTCTCTGCCACTAGGAACCAAGAGC
GGCGGCGCGCGTGGCAGGCCTCCCGGGAGAGCAAGCTGCAGCCCCTCCCCAGCTGTGAAGTATGGTGAGTCCAGCCGGCT
GGTGTGTGCGTGCTGGGGGGGCCCCAGACCGGGAGACTCGGGCCTGACATAGCCTGGCCCCCGTGCCCACAGTGCCACGC
CAAGTCCTGAGGAGGTGCAGAGCTGGGCGCAGTCTTTTGACAAGCTGATGCACAGCCCAGCGGGACGCAGCGTGTTCCGG
GCGTTCCTGCGGACAGAGTACAGCGAGGAGAACATGCTCTTCTGGTTGGCCTGCGAGGAGCTGAAGGCCGAGGCCAACCA
GCATGTGGTAGACGAGAAGGCGAGGCTCATCTACGAGGACTACGTATCCATCCTGTCCCCCAAGGAGGTGCGCCAGACAC
CAGAACAGGCCGGGGGCCGCCTGCTCCAGGCACTAGGTGGGGAAGGCAGCTCCCGCACCCCCTGACCTCAGTGTCTTGTC
CTGCAGGTGAGCCTGGACTCCCGTGTGCGGGAGGGCATCAACAAGAAGATGCAGGAGCCGTCCGCACACACGTTCGACGA
CGCGCAGCTGCAGATCTACACGCTCATGCACCGGGACTCCTACCCCCGCTTCCTCAGCTCTCCCACCTACCGTGCCCTGC
TGCTGCAGGGGCCATCACAGTCCTCCTCCGAGGCCTAGGCCGCCCCCAGCAGCACAGACCCCGCCGCCTCCTACGGCCGA
CTCTGGGTTCCCTTCAGGTGTTGTTGTCGGCAGGGCTGTCAGGGCACATGCCTGGCCGGCTGGGGTCCCCACCCGCGGAG
ACGGTCCTAGACCCAGTGGGGAGTGCTGTGTCTCCTGGGTCTGCCCACCCGTGGCCAAGCAGGAACTCCAGGTGCAGGGC
GGGCCTCCAGGTGCAGGGCGGGCCAGAAGCCCCCTCATCGGCCCGCAGCTGGCTGGCCCAGTGCTCCTGGCTGGGGGCTC
TTGCGTGGTGAGAGTAGGGGTCCCCCCAGGAGCCATGCTGGACCCATGAGCCTCGCTGGGGCCTCCTCCCCAGGCAGCCA
ATGGGCCCCAGACAAGCCTTTGGTGGGGAACAGAACCTCCGCATCGTGTAGTTTTGTGACATAAGGAGACCTCCTACTTG
AGCTGTCTGTACCCCAGAATCAAACACAGAACCTCAGAACCAGATTTAGGACCTCAGAATCCTGCACTCAAGGTGGCAGG
ACCCAATTTCTGTTTTATATGTTCATGAACTTTAAACCTGGAAACATGTCCTTACTAGGTGTTTTATCAAAAAAAAGTTT
TCATATTTATCTCTATCCCTAACCCCCCAAAAATAGGATGTCTTATTATTGAAGATATTTTTAAAGCAAAG
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Primary source |
RefSeq : NM_005873.2 (GI:86990433)
|
Name |
Regulator of G-protein signaling 19 (RGS19), transcript variant 1
|
Type of transcript |
mRNA
|
Organism |
Homo sapiens
|
Length |
1593 nt
|
Map |
20q13.33
|
Location |
Chromosome 20 (NC_000020.10) strand : -
62704533...62705396 | 62705496...62705730 | 62705819...62705893 | 62707877...62707998 |
62708209...62708306 | 62710646...62710844 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 2
|
1
|
199
|
199
|
1
|
Exon 3
|
200
|
297
|
98
|
1
|
Exon 4
|
298
|
419
|
122
|
1
|
Exon 5
|
420
|
494
|
75
|
1
|
Exon 6
|
495
|
729
|
235
|
1
|
Exon 7
|
730
|
1593
|
864
|
1
|
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ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
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Primary source |
NCBI : CCDS13555
|
Nucleotide |
RGS19, mRNA isoform 1[NM_005873.2] : 268...921
|
Length |
654
|
Location |
Chromosome 20 (NC_000020.10) strand : -
62705205...62705396 | 62705496...62705730 | 62705819...62705893 | 62707877...62707998 |
62708209...62708238 |
|
Start codon |
1
|
Translation |
NP_005864.1 |
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|
1 |
AGCTGTAGGG |
GAGGCGCTGC |
GCCCCCGGCC |
CCAGCCGATC |
GGGGGCTCCT |
GGCGCTAGCC |
TCCCTCCAGA |
GCGCCGCAGG |
|
81 |
AGTCCCTCCT |
GCCGTCTGAC |
TTGAGTCCCT |
GCTGCTGCAG |
TGCACGCCCC |
TTCGGCAGCC |
AGGGTGGGGC |
CCAGACCCAA |
|
161 |
CCTGGCCCCT |
CCTGCCCCCA |
CCCCGCCTTT |
GGGTCGCTGA |
CCCCCAGGCT |
GTGGTGAGGG |
TCTGAGAGCT |
GGTACCACGG |
|
241 |
AGCCTGGGCA |
ACCTCCTCCG |
CCCACCCATG |
CCCACCCCGC |
ATGAGGCTGA |
GAAGCAGATC |
ACAGGGCCAG |
AGGAGGCGGA |
|
321 |
CCGGCCCCCT |
TCAATGTCCA |
GTCATGATAC |
AGCCTCTCCA |
GCGGCCCCCA |
GCCGCAACCC |
CTGCTGCCTG |
TGCTGGTGCT |
|
401 |
GCTGCTGTAG |
CTGCTCCTGG |
AACCAAGAGC |
GGCGGCGCGC |
GTGGCAGGCC |
TCCCGGGAGA |
GCAAGCTGCA |
GCCCCTCCCC |
|
481 |
AGCTGTGAAG |
TATGTGCCAC |
GCCAAGTCCT |
GAGGAGGTGC |
AGAGCTGGGC |
GCAGTCTTTT |
GACAAGCTGA |
TGCACAGCCC |
|
561 |
AGCGGGACGC |
AGCGTGTTCC |
GGGCGTTCCT |
GCGGACAGAG |
TACAGCGAGG |
AGAACATGCT |
CTTCTGGTTG |
GCCTGCGAGG |
|
641 |
AGCTGAAGGC |
CGAGGCCAAC |
CAGCATGTGG |
TAGACGAGAA |
GGCGAGGCTC |
ATCTACGAGG |
ACTACGTATC |
CATCCTGTCC |
|
721 |
CCCAAGGAGG |
TGAGCCTGGA |
CTCCCGTGTG |
CGGGAGGGCA |
TCAACAAGAA |
GATGCAGGAG |
CCGTCCGCAC |
ACACGTTCGA |
|
801 |
CGACGCGCAG |
CTGCAGATCT |
ACACGCTCAT |
GCACCGGGAC |
TCCTACCCCC |
GCTTCCTCAG |
CTCTCCCACC |
TACCGTGCCC |
|
881 |
TGCTGCTGCA |
GGGGCCATCA |
CAGTCCTCCT |
CCGAGGCCTA |
GGCCGCCCCC |
AGCAGCACAG |
ACCCCGCCGC |
CTCCTACGGC |
|
961 |
CGACTCTGGG |
TTCCCTTCAG |
GTGTTGTTGT |
CGGCAGGGCT |
GTCAGGGCAC |
ATGCCTGGCC |
GGCTGGGGTC |
CCCACCCGCG |
|
1041 |
GAGACGGTCC |
TAGACCCAGT |
GGGGAGTGCT |
GTGTCTCCTG |
GGTCTGCCCA |
CCCGTGGCCA |
AGCAGGAACT |
CCAGGTGCAG |
|
1121 |
GGCGGGCCTC |
CAGGTGCAGG |
GCGGGCCAGA |
AGCCCCCTCA |
TCGGCCCGCA |
GCTGGCTGGC |
CCAGTGCTCC |
TGGCTGGGGG |
|
1201 |
CTCTTGCGTG |
GTGAGAGTAG |
GGGTCCCCCC |
AGGAGCCATG |
CTGGACCCAT |
GAGCCTCGCT |
GGGGCCTCCT |
CCCCAGGCAG |
|
1281 |
CCAATGGGCC |
CCAGACAAGC |
CTTTGGTGGG |
GAACAGAACC |
TCCGCATCGT |
GTAGTTTTGT |
GACATAAGGA |
GACCTCCTAC |
|
1361 |
TTGAGCTGTC |
TGTACCCCAG |
AATCAAACAC |
AGAACCTCAG |
AACCAGATTT |
AGGACCTCAG |
AATCCTGCAC |
TCAAGGTGGC |
|
1441 |
AGGACCCAAT |
TTCTGTTTTA |
TATGTTCATG |
AACTTTAAAC |
CTGGAAACAT |
GTCCTTACTA |
GGTGTTTTAT |
CAAAAAAAAG |
|
1521 |
TTTTCATATT |
TATCTCTATC |
CCTAACCCCC |
CAAAAATAGG |
ATGTCTTATT |
ATTGAAGATA |
TTTTTAAAGC |
AAA |
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>gi|86990433|ref|NM_005873.2|Regulator of G-protein signaling 19 (RGS19), transcript variant 1
AGCTGTAGGGGAGGCGCTGCGCCCCCGGCCCCAGCCGATCGGGGGCTCCTGGCGCTAGCCTCCCTCCAGAGCGCCGCAGG
AGTCCCTCCTGCCGTCTGACTTGAGTCCCTGCTGCTGCAGTGCACGCCCCTTCGGCAGCCAGGGTGGGGCCCAGACCCAA
CCTGGCCCCTCCTGCCCCCACCCCGCCTTTGGGTCGCTGACCCCCAGGCTGTGGTGAGGGTCTGAGAGCTGGTACCACGG
AGCCTGGGCAACCTCCTCCGCCCACCCATGCCCACCCCGCATGAGGCTGAGAAGCAGATCACAGGGCCAGAGGAGGCGGA
CCGGCCCCCTTCAATGTCCAGTCATGATACAGCCTCTCCAGCGGCCCCCAGCCGCAACCCCTGCTGCCTGTGCTGGTGCT
GCTGCTGTAGCTGCTCCTGGAACCAAGAGCGGCGGCGCGCGTGGCAGGCCTCCCGGGAGAGCAAGCTGCAGCCCCTCCCC
AGCTGTGAAGTATGTGCCACGCCAAGTCCTGAGGAGGTGCAGAGCTGGGCGCAGTCTTTTGACAAGCTGATGCACAGCCC
AGCGGGACGCAGCGTGTTCCGGGCGTTCCTGCGGACAGAGTACAGCGAGGAGAACATGCTCTTCTGGTTGGCCTGCGAGG
AGCTGAAGGCCGAGGCCAACCAGCATGTGGTAGACGAGAAGGCGAGGCTCATCTACGAGGACTACGTATCCATCCTGTCC
CCCAAGGAGGTGAGCCTGGACTCCCGTGTGCGGGAGGGCATCAACAAGAAGATGCAGGAGCCGTCCGCACACACGTTCGA
CGACGCGCAGCTGCAGATCTACACGCTCATGCACCGGGACTCCTACCCCCGCTTCCTCAGCTCTCCCACCTACCGTGCCC
TGCTGCTGCAGGGGCCATCACAGTCCTCCTCCGAGGCCTAGGCCGCCCCCAGCAGCACAGACCCCGCCGCCTCCTACGGC
CGACTCTGGGTTCCCTTCAGGTGTTGTTGTCGGCAGGGCTGTCAGGGCACATGCCTGGCCGGCTGGGGTCCCCACCCGCG
GAGACGGTCCTAGACCCAGTGGGGAGTGCTGTGTCTCCTGGGTCTGCCCACCCGTGGCCAAGCAGGAACTCCAGGTGCAG
GGCGGGCCTCCAGGTGCAGGGCGGGCCAGAAGCCCCCTCATCGGCCCGCAGCTGGCTGGCCCAGTGCTCCTGGCTGGGGG
CTCTTGCGTGGTGAGAGTAGGGGTCCCCCCAGGAGCCATGCTGGACCCATGAGCCTCGCTGGGGCCTCCTCCCCAGGCAG
CCAATGGGCCCCAGACAAGCCTTTGGTGGGGAACAGAACCTCCGCATCGTGTAGTTTTGTGACATAAGGAGACCTCCTAC
TTGAGCTGTCTGTACCCCAGAATCAAACACAGAACCTCAGAACCAGATTTAGGACCTCAGAATCCTGCACTCAAGGTGGC
AGGACCCAATTTCTGTTTTATATGTTCATGAACTTTAAACCTGGAAACATGTCCTTACTAGGTGTTTTATCAAAAAAAAG
TTTTCATATTTATCTCTATCCCTAACCCCCCAAAAATAGGATGTCTTATTATTGAAGATATTTTTAAAGCAAA
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Primary source |
RefSeq : NM_001039467.1 (GI:86990434)
|
Name |
Regulator of G-protein signaling 19 (RGS19), transcript variant 2
|
Type of transcript |
mRNA
|
Organism |
Homo sapiens
|
Length |
1493 nt
|
Map |
20q13.33
|
Location |
Chromosome 20 (NC_000020.10) strand : -
62704533...62705396 | 62705496...62705730 | 62705819...62705893 | 62707877...62707998 |
62708209...62708306 | 62711225...62711323 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
|
1
|
99
|
99
|
1
|
Exon 3
|
100
|
197
|
98
|
1
|
Exon 4
|
198
|
319
|
122
|
1
|
Exon 5
|
320
|
394
|
75
|
1
|
Exon 6
|
395
|
629
|
235
|
1
|
Exon 7
|
630
|
1493
|
864
|
1
|
|
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|
|
|
|
|
|
ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
rs6122246
|
SNP
|
563
|
g/t
|
1
|
?
|
dbSNP
|
rs6011280
|
SNP
|
887
|
g/t
|
1
|
?
|
dbSNP
|
rs1128674
|
SNP
|
1314
|
a/c
|
1
|
?
|
dbSNP
|
rs1128682
|
SNP
|
1353
|
c/t
|
1
|
?
|
dbSNP
|
rs10039
|
SNP
|
1373
|
c/t
|
1
|
?
|
dbSNP
|
rs71766720
|
insertion
|
1009
|
-/ctccaggtgcagggcgggc
|
19
|
?
|
dbSNP
|
|
|
|
|
|
|
|
|
|
|
|
|
Primary source |
NCBI : CCDS13555
|
Nucleotide |
RGS19, mRNA isoform 2[NM_001039467.1] : 168...821
|
Length |
654
|
Location |
Chromosome 20 (NC_000020.10) strand : -
62705205...62705396 | 62705496...62705730 | 62705819...62705893 | 62707877...62707998 |
62708209...62708238 |
|
Start codon |
1
|
Translation |
NP_001034556.1 |
|
|
|
|
|
|
|
|
|
|
|
|
1 |
CGCCTGCGCA |
CTGCGCCCCC |
GCGCCCCCTC |
CCCGACTGTC |
GGGCCGGACC |
TTGGAGCGCG |
CGGGCCGGCG |
GCGGCGCGAG |
|
81 |
TGGCTCGGGA |
GCGCGGCTGA |
CCCCCAGGCT |
GTGGTGAGGG |
TCTGAGAGCT |
GGTACCACGG |
AGCCTGGGCA |
ACCTCCTCCG |
|
161 |
CCCACCCATG |
CCCACCCCGC |
ATGAGGCTGA |
GAAGCAGATC |
ACAGGGCCAG |
AGGAGGCGGA |
CCGGCCCCCT |
TCAATGTCCA |
|
241 |
GTCATGATAC |
AGCCTCTCCA |
GCGGCCCCCA |
GCCGCAACCC |
CTGCTGCCTG |
TGCTGGTGCT |
GCTGCTGTAG |
CTGCTCCTGG |
|
321 |
AACCAAGAGC |
GGCGGCGCGC |
GTGGCAGGCC |
TCCCGGGAGA |
GCAAGCTGCA |
GCCCCTCCCC |
AGCTGTGAAG |
TATGTGCCAC |
|
401 |
GCCAAGTCCT |
GAGGAGGTGC |
AGAGCTGGGC |
GCAGTCTTTT |
GACAAGCTGA |
TGCACAGCCC |
AGCGGGACGC |
AGCGTGTTCC |
|
481 |
GGGCGTTCCT |
GCGGACAGAG |
TACAGCGAGG |
AGAACATGCT |
CTTCTGGTTG |
GCCTGCGAGG |
AGCTGAAGGC |
CGAGGCCAAC |
|
561 |
CAGCATGTGG |
TAGACGAGAA |
GGCGAGGCTC |
ATCTACGAGG |
ACTACGTATC |
CATCCTGTCC |
CCCAAGGAGG |
TGAGCCTGGA |
|
641 |
CTCCCGTGTG |
CGGGAGGGCA |
TCAACAAGAA |
GATGCAGGAG |
CCGTCCGCAC |
ACACGTTCGA |
CGACGCGCAG |
CTGCAGATCT |
|
721 |
ACACGCTCAT |
GCACCGGGAC |
TCCTACCCCC |
GCTTCCTCAG |
CTCTCCCACC |
TACCGTGCCC |
TGCTGCTGCA |
GGGGCCATCA |
|
801 |
CAGTCCTCCT |
CCGAGGCCTA |
GGCCGCCCCC |
AGCAGCACAG |
ACCCCGCCGC |
CTCCTACGGC |
CGACTCTGGG |
TTCCCTTCAG |
|
881 |
GTGTTGTTGT |
CGGCAGGGCT |
GTCAGGGCAC |
ATGCCTGGCC |
GGCTGGGGTC |
CCCACCCGCG |
GAGACGGTCC |
TAGACCCAGT |
|
961 |
GGGGAGTGCT |
GTGTCTCCTG |
GGTCTGCCCA |
CCCGTGGCCA |
AGCAGGAACT |
CCAGGTGCAG |
GGCGGGCCTC |
CAGGTGCAGG |
|
1041 |
GCGGGCCAGA |
AGCCCCCTCA |
TCGGCCCGCA |
GCTGGCTGGC |
CCAGTGCTCC |
TGGCTGGGGG |
CTCTTGCGTG |
GTGAGAGTAG |
|
1121 |
GGGTCCCCCC |
AGGAGCCATG |
CTGGACCCAT |
GAGCCTCGCT |
GGGGCCTCCT |
CCCCAGGCAG |
CCAATGGGCC |
CCAGACAAGC |
|
1201 |
CTTTGGTGGG |
GAACAGAACC |
TCCGCATCGT |
GTAGTTTTGT |
GACATAAGGA |
GACCTCCTAC |
TTGAGCTGTC |
TGTACCCCAG |
|
1281 |
AATCAAACAC |
AGAACCTCAG |
AACCAGATTT |
AGGACCTCAG |
AATCCTGCAC |
TCAAGGTGGC |
AGGACCCAAT |
TTCTGTTTTA |
|
1361 |
TATGTTCATG |
AACTTTAAAC |
CTGGAAACAT |
GTCCTTACTA |
GGTGTTTTAT |
CAAAAAAAAG |
TTTTCATATT |
TATCTCTATC |
|
1441 |
CCTAACCCCC |
CAAAAATAGG |
ATGTCTTATT |
ATTGAAGATA |
TTTTTAAAGC |
AAA |
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>gi|86990434|ref|NM_001039467.1|Regulator of G-protein signaling 19 (RGS19), transcript variant 2
CGCCTGCGCACTGCGCCCCCGCGCCCCCTCCCCGACTGTCGGGCCGGACCTTGGAGCGCGCGGGCCGGCGGCGGCGCGAG
TGGCTCGGGAGCGCGGCTGACCCCCAGGCTGTGGTGAGGGTCTGAGAGCTGGTACCACGGAGCCTGGGCAACCTCCTCCG
CCCACCCATGCCCACCCCGCATGAGGCTGAGAAGCAGATCACAGGGCCAGAGGAGGCGGACCGGCCCCCTTCAATGTCCA
GTCATGATACAGCCTCTCCAGCGGCCCCCAGCCGCAACCCCTGCTGCCTGTGCTGGTGCTGCTGCTGTAGCTGCTCCTGG
AACCAAGAGCGGCGGCGCGCGTGGCAGGCCTCCCGGGAGAGCAAGCTGCAGCCCCTCCCCAGCTGTGAAGTATGTGCCAC
GCCAAGTCCTGAGGAGGTGCAGAGCTGGGCGCAGTCTTTTGACAAGCTGATGCACAGCCCAGCGGGACGCAGCGTGTTCC
GGGCGTTCCTGCGGACAGAGTACAGCGAGGAGAACATGCTCTTCTGGTTGGCCTGCGAGGAGCTGAAGGCCGAGGCCAAC
CAGCATGTGGTAGACGAGAAGGCGAGGCTCATCTACGAGGACTACGTATCCATCCTGTCCCCCAAGGAGGTGAGCCTGGA
CTCCCGTGTGCGGGAGGGCATCAACAAGAAGATGCAGGAGCCGTCCGCACACACGTTCGACGACGCGCAGCTGCAGATCT
ACACGCTCATGCACCGGGACTCCTACCCCCGCTTCCTCAGCTCTCCCACCTACCGTGCCCTGCTGCTGCAGGGGCCATCA
CAGTCCTCCTCCGAGGCCTAGGCCGCCCCCAGCAGCACAGACCCCGCCGCCTCCTACGGCCGACTCTGGGTTCCCTTCAG
GTGTTGTTGTCGGCAGGGCTGTCAGGGCACATGCCTGGCCGGCTGGGGTCCCCACCCGCGGAGACGGTCCTAGACCCAGT
GGGGAGTGCTGTGTCTCCTGGGTCTGCCCACCCGTGGCCAAGCAGGAACTCCAGGTGCAGGGCGGGCCTCCAGGTGCAGG
GCGGGCCAGAAGCCCCCTCATCGGCCCGCAGCTGGCTGGCCCAGTGCTCCTGGCTGGGGGCTCTTGCGTGGTGAGAGTAG
GGGTCCCCCCAGGAGCCATGCTGGACCCATGAGCCTCGCTGGGGCCTCCTCCCCAGGCAGCCAATGGGCCCCAGACAAGC
CTTTGGTGGGGAACAGAACCTCCGCATCGTGTAGTTTTGTGACATAAGGAGACCTCCTACTTGAGCTGTCTGTACCCCAG
AATCAAACACAGAACCTCAGAACCAGATTTAGGACCTCAGAATCCTGCACTCAAGGTGGCAGGACCCAATTTCTGTTTTA
TATGTTCATGAACTTTAAACCTGGAAACATGTCCTTACTAGGTGTTTTATCAAAAAAAAGTTTTCATATTTATCTCTATC
CCTAACCCCCCAAAAATAGGATGTCTTATTATTGAAGATATTTTTAAAGCAAA
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|
Exon number |
1
|
Length |
99 nt
|
Location |
Chromosome 20 (NC_000020.10) : 62711225...62711323 (-)
|
Is part of |
RGS19, mRNA isoform 2
(NM_001039467.1)
|
Sequence |
Show
|
|
CGCCTGCGCACTGCGCCCCCGCGCCCCCTCCCCGACTGTCGGGCCGGACCTTGGAGCGCGCGGGCCGGCGGCGGCGCGAG
TGGCTCGGGAGCGCGGCTG
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Exon number |
2
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Length |
199 nt
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Location |
Chromosome 20 (NC_000020.10) : 62710646...62710844 (-)
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Is part of |
RGS19, mRNA isoform 1
(NM_005873.2)
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Sequence |
Show
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AGCTGTAGGGGAGGCGCTGCGCCCCCGGCCCCAGCCGATCGGGGGCTCCTGGCGCTAGCCTCCCTCCAGAGCGCCGCAGG
AGTCCCTCCTGCCGTCTGACTTGAGTCCCTGCTGCTGCAGTGCACGCCCCTTCGGCAGCCAGGGTGGGGCCCAGACCCAA
CCTGGCCCCTCCTGCCCCCACCCCGCCTTTGGGTCGCTG
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Exon number |
6
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Length |
235 nt
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Location |
Chromosome 20 (NC_000020.10) : 62705496...62705730 (-)
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Is part of |
RGS19, mRNA isoform 2
(NM_001039467.1)
RGS19, mRNA isoform 1
(NM_005873.2)
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Sequence |
Show
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TGCCACGCCAAGTCCTGAGGAGGTGCAGAGCTGGGCGCAGTCTTTTGACAAGCTGATGCACAGCCCAGCGGGACGCAGCG
TGTTCCGGGCGTTCCTGCGGACAGAGTACAGCGAGGAGAACATGCTCTTCTGGTTGGCCTGCGAGGAGCTGAAGGCCGAG
GCCAACCAGCATGTGGTAGACGAGAAGGCGAGGCTCATCTACGAGGACTACGTATCCATCCTGTCCCCCAAGGAG
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Exon number |
7
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Length |
864 nt
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Location |
Chromosome 20 (NC_000020.10) : 62704533...62705396 (-)
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Is part of |
RGS19, mRNA isoform 2
(NM_001039467.1)
RGS19, mRNA isoform 1
(NM_005873.2)
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Sequence |
Show
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GTGAGCCTGGACTCCCGTGTGCGGGAGGGCATCAACAAGAAGATGCAGGAGCCGTCCGCACACACGTTCGACGACGCGCA
GCTGCAGATCTACACGCTCATGCACCGGGACTCCTACCCCCGCTTCCTCAGCTCTCCCACCTACCGTGCCCTGCTGCTGC
AGGGGCCATCACAGTCCTCCTCCGAGGCCTAGGCCGCCCCCAGCAGCACAGACCCCGCCGCCTCCTACGGCCGACTCTGG
GTTCCCTTCAGGTGTTGTTGTCGGCAGGGCTGTCAGGGCACATGCCTGGCCGGCTGGGGTCCCCACCCGCGGAGACGGTC
CTAGACCCAGTGGGGAGTGCTGTGTCTCCTGGGTCTGCCCACCCGTGGCCAAGCAGGAACTCCAGGTGCAGGGCGGGCCT
CCAGGTGCAGGGCGGGCCAGAAGCCCCCTCATCGGCCCGCAGCTGGCTGGCCCAGTGCTCCTGGCTGGGGGCTCTTGCGT
GGTGAGAGTAGGGGTCCCCCCAGGAGCCATGCTGGACCCATGAGCCTCGCTGGGGCCTCCTCCCCAGGCAGCCAATGGGC
CCCAGACAAGCCTTTGGTGGGGAACAGAACCTCCGCATCGTGTAGTTTTGTGACATAAGGAGACCTCCTACTTGAGCTGT
CTGTACCCCAGAATCAAACACAGAACCTCAGAACCAGATTTAGGACCTCAGAATCCTGCACTCAAGGTGGCAGGACCCAA
TTTCTGTTTTATATGTTCATGAACTTTAAACCTGGAAACATGTCCTTACTAGGTGTTTTATCAAAAAAAAGTTTTCATAT
TTATCTCTATCCCTAACCCCCCAAAAATAGGATGTCTTATTATTGAAGATATTTTTAAAGCAAA
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Primary source |
Uniprot : P49795
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Name |
Regulator of G-protein signaling 19
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Alternative name(s) |
G-alpha-interacting protein
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Synonym(s) |
GAIP RGS19
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Organism |
Homo sapiens
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Length |
217 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Function
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Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
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Ptm
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Fatty acylated. Heavily palmitoylated in the cysteine string motif.
Phosphorylated, mainly on serine residues.
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Similarity
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Contains 1 RGS domain.
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Subcellular location
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Membrane; Lipid-anchor.
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Subunit
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Interacts with GIPC PDZ domain.
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Tissue specificity
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Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
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Biological process
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autophagy [GO:0006914]
G-protein coupled receptor protein signaling pathway [GO:0007186]
small GTPase mediated signal transduction [GO:0007264]
negative regulation of signal transduction [GO:0009968]
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Cellular component
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membrane fraction [GO:0005624]
Golgi apparatus [GO:0005794]
membrane [GO:0016020]
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Molecular function
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signal transducer activity [GO:0004871]
protein binding [GO:0005515]
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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Region |
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Compositional bias
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39 - 49
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11
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Poly-Cys
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P49795-COMPBIAS-39
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Domain
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90 - 206
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117
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RGS
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P49795-DOMAIN-90
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Region
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207 - 217
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11
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Interaction with GIPC
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P49795-REGION-207
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Amino acid modifications |
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Modified residue
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24 - 24
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1
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Phosphoserine (By similarity)
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P49795-MOD_RES-24
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Modified residue
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97 - 97
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1
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Phosphoserine
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P49795-MOD_RES-97
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Modified residue
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151 - 151
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1
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Phosphoserine; by MAPK1 and MAPK3
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P49795-MOD_RES-151
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Experimental info |
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Mutagenesis
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151 - 151
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1
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S->A: Diminishes gap activity towards G(i)-alpha3 and autophagy in colon cancer cells
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P49795-MUTAGEN-151
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1 |
MPTPHEAEKQ |
ITGPEEADRP |
PSMSSHDTAS |
PAAPSRNPCC |
LCWCCCCSCS |
WNQERRRAWQ |
ASRESKLQPL |
PSCEVCATPS |
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81 |
PEEVQSWAQS |
FDKLMHSPAG |
RSVFRAFLRT |
EYSEENMLFW |
LACEELKAEA |
NQHVVDEKAR |
LIYEDYVSIL |
SPKEVSLDSR |
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161 |
VREGINKKMQ |
EPSAHTFDDA |
QLQIYTLMHR |
DSYPRFLSSP |
TYRALLLQGP |
SQSSSEA |
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>sp|P49795|RGS19_human Regulator of G-protein signaling 19
MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPS
PEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSR
VREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
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