(CLN3) ceroid-lipofuscinosis, neuronal 3 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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8419
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Official symbol
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CLN3
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Official name
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ceroid-lipofuscinosis, neuronal 3
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 16 (NC_000016.9) : 28488599...28503622 (-)
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Map
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16p12
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Length
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15024 nt
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NM_001042432.1
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CLN3, mRNA isoform 1
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NM_000086.2
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CLN3, mRNA isoform 2
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Accession
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Name
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Organism
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Length
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Q13286
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Battenin
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Homo sapiens
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438 aa
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Q549S9
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CLN3 protein [submitted name]
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Homo sapiens
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438 aa
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Synonyms |
MGC102840; JNCL; BTS
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Alternative name(s) |
battenin; juvenile neuronal ceroid lipofuscinosis; Batten, Spielmeyer-Vogt disease
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Summary |
This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl
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1 |
TAACTGGTGC |
TGGCAGGCTA |
CTGTCTCGGT |
CTTGGGCGCC |
ACTGATCTAA |
GGTCACGGCT |
CTGCTTGCTG |
CTCCCACCCG |
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81 |
CTCCAGTTTA |
AAACCTGCGG |
TTCCAGGGTT |
CTCCAGCCCC |
TCCCTTTTTC |
ACGCTCCGAA |
GCCGAGAAGG |
CCCAAAGCGA |
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161 |
AGACAGAGAG |
GACCCGGAAG |
TAGGGAAAAC |
CTCTGAGCAC |
GTGATGGGGG |
AACACGCGGG |
TGCTGTCACG |
TGATCCGACA |
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241 |
AACGGCCTCT |
GCATAGTGCA |
GAACATTCTG |
CTGCTCTTAA |
AGGTACAGGC |
CTCAGGGTCC |
CTGCTGTAGA |
CGGGGCGGGG |
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321 |
GAGAGTACGA |
TGGGTGGGGC |
GTGGTGGGTC |
GTAGGGCGCT |
CGAGATGGAG |
CCCCCAGCTT |
CCTTGATGGA |
TCGCGGGGCG |
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401 |
CGAGTGCCCT |
AGACAAGCCG |
GAGCTGGGAC |
CGGCAATCGG |
GCGTTGATCC |
TTGTCACCTG |
TCGCAGACCC |
TCATCCCTCC |
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481 |
CGTGGGAGCC |
CCCTTTGGAC |
ACTCTATGAC |
CCTGGACCCT |
CGGGGGACCT |
GAACTTGATG |
CGATGGGAGG |
CTGTGCAGGC |
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561 |
TCGCGGCGGC |
GCTTTTCGGA |
TTCCGAGGGT |
GAGTATTCCC |
GCCCACCCTC |
ATGGAACGAC |
CACCTCTGGC |
TCGCAGCCCA |
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641 |
CCTGAGGGGA |
ATGAGAGCTG |
ACTCGGCCCC |
GGGAGGACAC |
GCAAGGAGCG |
GTCGTGCACC |
TGAGAGTAGG |
TGGGGGTCAT |
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721 |
GCCCTCTTCT |
CGCTCTCCCA |
GGGGAGGAGA |
CCGTCCCGGA |
GCCCCGGCTC |
CCTCTGTTGG |
ACCATCAGGG |
CGCGCATTGG |
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801 |
AAGAACGCGG |
TGGGCTTCTG |
GTGAGTGGCC |
TGAGACTTCA |
GCGAGTGACA |
ATGGCATGAG |
AAGAGGGAAG |
TGACCGGAGG |
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881 |
AAAGGGGGAA |
GAAAGAGTTA |
AGCTGCGCAA |
AGGAGCTGAA |
CCCACAAATA |
TTTACTGAAT |
CCACTGGTTT |
GCCCCAGGGG |
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961 |
CAGCATGTAA |
AATTTCCAAA |
CTTCACTCCT |
TATCACCTTC |
CGGATTTAGC |
AAGATCCTCA |
TACCTACCAC |
CTGTAGGATT |
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1041 |
ATTTACTTTT |
TTCTTCCAGC |
CAATTCAGCC |
TTAACGTTTT |
TTAGTGCACA |
TATTTTTAAA |
AAGAAAACTT |
TAAATCACGA |
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1121 |
CTCCACTTGG |
AAAACCAGCG |
TTTTCCTAGT |
GAACGTTTAA |
ATAAATGCAT |
CACTACTAAA |
ACTTTTTTAT |
TTTTTTAATT |
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1201 |
TATTTTATTT |
TATCTTATTT |
TTTTTTCTTT |
TTGAGACAGG |
GTCTTGCTCT |
GTTTCCCAGG |
TTGGAATGCA |
GTAGTGCAAT |
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1281 |
CACAGCTCCC |
TGCAGCCTGG |
AACTCCTGGG |
CTCAAGTGAT |
TCTCCCACCT |
CAGCCTCCAA |
GTAGGTGTGG |
CTACAGGTGT |
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1361 |
GCACCACCGC |
ATCTGCCTAA |
TTTTTATATT |
TTTTTATAGA |
GATGGGGGTC |
TCACTATGGG |
ACCTGGGCTG |
GTCTCAAACT |
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1441 |
CGTGGCCTCA |
AGTGATCCTC |
CTACCTCAAC |
CTTCCAAAGT |
GCTGAGATTA |
CAAGCATGAG |
CCACCATGCC |
GGGCCTGAAC |
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1521 |
CTTTTTTTTT |
TTTTTTTTTT |
TTGAGACGGA |
GTCTCTCTCT |
GTCCTCCAGG |
CTGGAGTGCA |
GTGGCGCAAT |
CTCGGCTCAC |
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1601 |
TGCAAACTCC |
GCCTCCCAGG |
TTCACACCAT |
TCTTTTGCCT |
CAGCCTCCGG |
AGTAGCTGAG |
ACTACAGGCG |
CCTGCCACCA |
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1681 |
CGCCCGGCTA |
TTTTTTTGTA |
TTTTTAGTAG |
AGATGGGGTT |
TCACCGCGTT |
ATCCAGGATG |
GTCTCGATCT |
CCTGACCTCG |
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1761 |
TGATCCGCCC |
GCCTCGGCCT |
CCCAAAGTGC |
TGGGATTACA |
GGTGTGAGCC |
ACCGCGCCCA |
GCTTTTTTTT |
TTTTTTTTTT |
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1841 |
TAATTTTATT |
TTATTTTTGA |
GACAGAGTCT |
CACTCTATCA |
CCCAGGCTGG |
AGAGCAGTGG |
CACAATCTCG |
GCTCACTGAA |
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1921 |
ACCTCCACCT |
CCAAGGTTCA |
AGCTATTCTC |
CTGTCTCAGC |
TCCCCGAGTA |
GCTGGGATTA |
CAGGTGCGTG |
CCACCAGACA |
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2001 |
CAGCTAATTT |
TTTGTATTTT |
TAGTAAAGAC |
AGGATTTCAC |
CATGTTGGTC |
AGGCTGGTCT |
AGAACTCCTG |
ACCTTAGGTG |
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2081 |
ATCCGCTTGC |
CTCCACTTCC |
CAAAGTGCTG |
GGATTACAGG |
CGTGAGCCAC |
CGTGCCCCGC |
CCTGACATAG |
GGGCTTTGGG |
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2161 |
ATCACAGACT |
TGGATTCACT |
TCCAGCCTCC |
AAGGCCTCTC |
CCAGAAACTC |
TCTGTGACCA |
CTCTCCTTTT |
TTTTTTTTTT |
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2241 |
TTTTGAGATA |
GAGTCTCGCT |
CTTGTAGCCC |
AGGCTGGAGT |
GCAATGGCAC |
AATCTCGGCT |
TACTGCAACC |
TCCGCCTTTC |
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2321 |
GGGTTCAAGT |
GGTTCTCCTG |
CCTCAGCCTC |
CTGAGTAGCT |
AGGATTACAG |
GCATGTGCAA |
CTTCGCCCAG |
CTAATTTTGT |
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2401 |
ATTTTTTAGT |
AGAGACGGGG |
TTTCTCCATA |
TTGCTCAGGC |
TGGTCTCGAA |
CTCCTGACCT |
CAGGCGATCC |
GCCCGCCTCG |
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2481 |
GCCCCTCAAA |
GTGCTGGAAT |
TACAGGTGTG |
AGCCACTGCA |
CTCGGCCTCT |
TCCTTTTTAT |
TTTTTATTTT |
TGTGACAGGG |
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2561 |
TCTTGCTCTG |
TCACCCAGGC |
TAGAGTGCAG |
TGGCATGATC |
ACAGTTCACT |
GCAGCCTCTG |
ACTCCTGGAC |
TCAAGCAATC |
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2641 |
CTCCCACCTC |
AGCCTCCCAA |
GTAGCTGGGA |
CTACAGTGCA |
AGCCACCACA |
CCTGGCTAAT |
TTTTAAATTT |
TTTGTAGAGA |
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2721 |
TGGGGGTCTC |
ACTATCTTGC |
CCAAGCACCA |
AAGCCTGTAT |
TTTTGACCCC |
AACATTGAAT |
GAGGATGGGA |
TCTGGTGATA |
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2801 |
GAGGGAAAAA |
AAAGAGGGGG |
CTGATTGAAG |
GGCACAGGTA |
AGGGAAGGTT |
TGGCACAAAG |
GCTACAGATG |
GCTGCAGGAT |
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2881 |
GAGGAGGGAG |
TTGAGACCTG |
TCCTGCTCCT |
TCCAGGCTGC |
TGGGCCTTTG |
CAACAACTTC |
TCTTATGTGG |
TGATGCTGAG |
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2961 |
TGCCGCCCAC |
GACATCCTTA |
GCCACAAGAG |
GACATCGGGA |
AACCAGAGCC |
ATGTAAGTGA |
CTCTCTACCA |
CCACCACCAT |
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3041 |
GGTTAGTCCC |
TGTGGGAAGA |
TGAGGGGGTG |
GGACAAGGTG |
GGGTAAAGTT |
TCCAGTCTCT |
GGCTGGGCAC |
AGTGGCTCAC |
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3121 |
ACCTGTAATC |
CCAGCAGTTT |
GGGAGGCTGA |
GGCGGGCGGA |
TCACTTGAAG |
TCAGGAGTTC |
GAGACCAGCC |
TGGCCAACAT |
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3201 |
GGTGAAACTC |
CGACTCTACT |
AAAAATACAA |
AAACTACCTG |
GGTGTGGTGG |
CACACACCTG |
TAGTCTGAGC |
TATTCAGGAG |
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3281 |
GCTGAGGCAG |
GAGAATTGCT |
TGAAGCCAGG |
AGGTGGAAGT |
TGCAATGAGC |
CAAGATCACA |
CCACTGCACT |
CTAGCTTGGG |
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3361 |
CAACAGAGTG |
AGACACCATC |
TCAAAAAAAA |
GAAAGCTCTT |
GAATGTGTTA |
TCTAAACAAA |
GTCCATTTAC |
AGGGCCATCT |
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3441 |
GTGGCCTGTG |
GTCTAGTAGT |
GTGAGACTCA |
TATGGAAACC |
CCCTCTTCAT |
TGTGCATGCA |
GAGACGCTGA |
GGTCCTGAGA |
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3521 |
AGTCAGTCAC |
TGCTGACCCA |
AAGCCATCCT |
TCAAGTGAAG |
GCAGAGCTGG |
GACGGGAGCC |
AGGCTCTGTG |
TGTCTATCCC |
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3601 |
TCTGCCTCCA |
GGGTGAAAGA |
CATGCTTTTC |
TCCCATTAGG |
TGGACCCAGG |
CCCAACGCCG |
ATCCCCCACA |
ACAGCTCATC |
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3681 |
ACGATTTGAC |
TGCAACTCTG |
TCTCTACGGC |
TGTGCGTACT |
CATCTCACCT |
GGTCCTTGCC |
TGACCCAGGG |
CCCCTGGGTC |
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3761 |
TATAGACCCC |
ACTCCCAGCC |
CTTCACTACC |
CAGCTGGGAC |
TGTCATGATT |
AAAACAGTTG |
AGACCTGGGC |
TGGGCGCACT |
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3841 |
GGCTCACACT |
TGTAATCCCA |
GCACTTTGGG |
AGACCAAGGT |
GGGAGGATCA |
CTTGAGCCTA |
GGAGTTTGAG |
ACCAGCCTGG |
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3921 |
GCAGTATAGT |
GAGACCCCCA |
TCTTAAAGAA |
AAAAATTAAA |
AAATATATAT |
ATATAAAATA |
ATTGAGACCT |
TAATATAATT |
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4001 |
TCTGAGGCTG |
AGGCGGATGG |
ATCACTTGAG |
ACCAGGAGTT |
CAAGACCAGC |
CTGGCCAACA |
TGGTGAAACC |
CCATCTGTAC |
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4081 |
TAAAAATACA |
AAAATTAGCC |
AGGCATGGTG |
GTGCACGCCT |
GTAATCCCAG |
CTACTCAGGA |
GGCTGAGGCA |
GGAGAATCAC |
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4161 |
TTGAACCCAG |
GAGGTGGAGG |
TTGTAGTGAG |
CCAAGATCGA |
GCCACTACAC |
TCCAGCCTGG |
GTGGCAGAAT |
GAGACTCACT |
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4241 |
CTCAAAATAT |
ATATATATAT |
AGTTTCTGAG |
TCCTTTCTGT |
CTGCACCATA |
TATTAGCTCA |
TTTAAGCCAC |
ACAGCAGTCC |
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4321 |
TGTGAGCTAG |
GTGCTATGAT |
ATTCCCATTT |
TCCAGATGAG |
GAAACTGAAG |
CTCAGAGAGT |
ATAAACTCTT |
GACACACAAC |
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4401 |
TAAGGAGTGG |
GAGAGCTGAG |
ACTTGAACCC |
AGGCGTGCCT |
GACTCCAGAG |
CCTGTGTTTG |
TAGCAGGCCT |
GTTTGGCCAG |
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4481 |
CTCCTGCCTC |
TCCTTGGCCA |
CGTGGTTGGG |
AGGGTTGTCC |
CCTGGAAGCT |
CTGCGGTCTC |
ACTCTATTCT |
CCTGTCCCAG |
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4561 |
GCTGTGCTCC |
TGGCGGACAT |
CCTCCCCACA |
CTCGTCATCA |
AATTGTTGGC |
TCCTCTTGGC |
CTTCACCTGC |
TGCCCTACAG |
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4641 |
GTCTGGGTGA |
GGGTAGTGGG |
AGGCAGGGTG |
GGCAGGAGCT |
GAGAAAGGGG |
AGGCTGGGAT |
GGCTGAGATG |
CTGAGAGTAG |
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4721 |
AGACCGACCT |
TCCCCCTCCC |
TTCCCTTCTC |
ACCCCCTCAG |
CCCCCGGGTT |
CTCGTCAGTG |
GGATTTGTGC |
TGCTGGAAGC |
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4801 |
TTCGTCCTGG |
TTGCCTTTTC |
TCATTCTGTG |
GGGACCAGCC |
TGTGTGGTGA |
GTGTGTGGTT |
CTGTGTCAGA |
TGGGGAGCCC |
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4881 |
CGAGGAACCA |
CATCAGAGCA |
TTTGTGGGAA |
GAGTCTCCCC |
AGCCTCCCAG |
AGGAAAGGGA |
TTCATTCTGT |
CACCCTTAGA |
|
4961 |
AGCCTGCTAG |
GGCTATCAGC |
AGTAGGCGAT |
GGGAGACTGG |
GACAATTTGG |
AGGGGTAGGC |
AGTGGAGGAG |
ATGGGAGAAA |
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5041 |
ATGGATGAAT |
TAGATGGAGA |
TTGAGGTGAA |
CAAAGTCAAG |
ACTCTGTGAT |
GGACCAGGCA |
CAGTGACTCA |
TGCCTATAAT |
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5121 |
CCCAGCACTT |
TGGAAAGCCA |
AGGCAGGCAG |
ATCACCTGAG |
GTCAGGAGTT |
CGAAACCAGC |
CTGGCCAACA |
TGGAGAAACC |
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5201 |
CCGTCTCTAC |
CAAAAATACA |
AAAATTAGCT |
GGGTGTGGTG |
GCAGGAGCCT |
GTAATCCCAG |
CTACTCGGGA |
GGCTGAGGCA |
|
5281 |
GGAGAATCTC |
TTGAACCTGG |
GAGGCAGAGG |
TTGCAGTGAG |
CCGAGATCAC |
GCCACTGTAC |
TCCAGCCTGG |
GTGACAGGGC |
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5361 |
GAGACTCCGT |
CTCCAAAAAG |
AAAAGAAAAG |
AAAAAGACTG |
ATGAAGGGGC |
AGAGACATCA |
AGGGTGCATG |
TCTGCCCCTG |
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5441 |
GTCTGATAAC |
TGGGTGGATG |
GAGGTGCCAC |
TCTCCATGAA |
GGGACACGCA |
GGGGAGTGGG |
GCTCTGCTTC |
AGACCTGGAA |
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5521 |
CCTGGCCTAT |
GCATGGGATC |
TATTGGAGCC |
TCTATGAGCT |
GATACTGAGG |
AGGCCATGGC |
CAGACACATT |
AGAGGCCTGG |
|
5601 |
GCAGTGTGGC |
AAGGTGTGGT |
GTGACCATCC |
CAGTGCTTGT |
CCTCCCCCCA |
GGTGTGGTCT |
TCGCTAGCAT |
CTCATCAGGC |
|
5681 |
CTTGGGGAGG |
TCACCTTCCT |
CTCCCTCACT |
GCCTTCTACC |
CCAGGTAAGC |
AGGTGGAGCA |
GGGAGTGTGG |
GGAGAGGCTG |
|
5761 |
TCCCATGGTC |
AGCCTAGGTC |
CTCCTGAATG |
TTCCTGTGTT |
CTCCTTCCCA |
GGGCCGTGAT |
CTCCTGGTGG |
TCCTCAGGGA |
|
5841 |
CTGGGGGAGC |
TGGGCTGCTG |
GGGGCCCTGT |
CCTACCTGGG |
CCTCACCCAG |
GCCGGCCTCT |
CCCCTCAGCA |
GACCCTGCTG |
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5921 |
TCCATGCTGG |
GTATCCCTGC |
CCTGCTGCTG |
GCCAGGTGAG |
CTGCCCTGAG |
CCGGGAGGGA |
GAGGGGTCCA |
AGGAGAGAAA |
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6001 |
ACTTGGCCAT |
GGCTGGGTGT |
GGTGGCTCAC |
GCCTGTAATC |
CCAGCACTTT |
GGGAGGCCAA |
GGAGGGCAGA |
TCGCCTAAGG |
|
6081 |
TCAGGAAACC |
AGCCTGGCCA |
ACATGGTGAA |
ACCCCGTCTC |
TACTAAAAAT |
ACAACAATTA |
GCCAGGTGTG |
GTGGCGGGTG |
|
6161 |
CCTGTAGTCC |
CAACTACTCA |
GGAGGCTAAG |
GCAGGAGAAT |
CGCTTGAACC |
CCGGAGGCAG |
TGGTGGCAGT |
GAGCCGAGAT |
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6241 |
CGTGCCATTG |
CACTCCAGCC |
CGGGCGACAG |
AGTTAGACTC |
TGTCTCAGGA |
AGAAAAAAAA |
AAAAAGAAAG |
AAAAGAAAAC |
|
6321 |
TTGATTATGA |
TTGCAATCTT |
CAAGTCCCTA |
CCTTGCTGTG |
AAGGGAGGCG |
GAATCTGGAC |
TCTGATAGCC |
CCAGGTGTGA |
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6401 |
GTCCTGGAGC |
TGCCACTTTT |
TAGCTTTGTA |
GCGTTGAACA |
AGTTACTCCA |
CCTCTCTGAA |
CCCTCAGTTT |
CCCCATATCT |
|
6481 |
CAAATGGCAG |
TTGTTCTTGC |
TTTCCTTGGA |
GGTGATGAGG |
GTAATGCATT |
CAGCACAGTG |
TGGTTCCCAA |
GGTGATTAGA |
|
6561 |
AGTAGGATGA |
GGGTGGACTT |
TATTTGATTA |
GTTCCTTTTT |
TTTTTTTTTT |
TTTTTTTAAT |
CAGTGTTGAC |
CAGGTTGGCC |
|
6641 |
TCGAATGTGT |
AGCCTTGCCT |
GCCTGAGTGC |
CAGGGCAACA |
GGCCTGAACC |
ATGGCGACTC |
CCTTTTTTTT |
TTTTTTTTTT |
|
6721 |
TTTTTTTTTT |
GAGACGGAGT |
CTCATGGTGT |
CACTCAGGCT |
GGAGTGCAGT |
GACTGGTGTG |
ATCTCAGCTC |
ACTGCAGCCT |
|
6801 |
CGGCCTCCCG |
GGCTCTAGTG |
ATTCTCCTGC |
CTCAGCCTCC |
CGAGTAGCTG |
GGACTACAGG |
CCCATGCCAC |
CATGCCTGGC |
|
6881 |
TAATTTTTTA |
TATTTTTAGT |
AGAGACGGGG |
TTTCACTGTA |
TTGGCCAGGC |
TGGTCTCAAA |
CTCCTGACCT |
CAAGTGATCC |
|
6961 |
ACCTGCCTTG |
GCCTCCCATA |
ATGCTAGGAA |
TACAGGCGTG |
AGCCACCGCG |
CCCGGCCTGA |
TTAGTTCTGT |
GTATTTTCAT |
|
7041 |
GCATATTACA |
AAACACTTTG |
GCCGGGCATG |
GTGGCTCACA |
TCTGTAATCC |
CAGCACTTTG |
GGAGGCCGAG |
GCGGGCGCAC |
|
7121 |
CACGAGGTCA |
GGAGTTTGAG |
ACCAGCCTGG |
CCAATATGGT |
GAAACCCCGT |
CTCTACTAAA |
AATACAAAAA |
TTAGCCAGGC |
|
7201 |
TTGGTGGCGC |
TTGCCTGTAG |
TCCCAGCTAC |
TTGGGAGGCT |
GAGGAGAAGA |
ATCGCTTGAA |
CCCAGGAGGC |
AGAGGTTGCA |
|
7281 |
GTGAGCCGTG |
ATTGTGCCAC |
TGCACTCCAG |
GCTGGGCAAC |
AGAGCGAGAC |
TCCGTCTAAA |
AAAAAAAAAA |
ACACACACTT |
|
7361 |
TGAACTAGCC |
AGACACACCT |
GGCCCTTCAC |
AAGATTAGTG |
CTTAGGACAA |
GTCTAAGTAG |
AAAAAGTGAG |
TCCATTTAAA |
|
7441 |
GAAAAATATT |
AAGTAAAAAT |
ATATATATAC |
AGGAGGAATA |
TGGATATGGC |
AAATAACATG |
AAGCCAGAAC |
CTAAGTGACT |
|
7521 |
AAAATCGAGG |
AAGTTCTGGC |
CTAGCACAGA |
GTGAACGTAT |
AATTAATGGG |
AGCTAGAGCG |
ACCATTAGAA |
TAATAATGGC |
|
7601 |
CAGAAAACAG |
AACTGACTCG |
CTAGGTATGA |
GCCAGCAGTC |
CGAACAAGGG |
CCTGCTGAGC |
ACAGTGGCTC |
ACAGCTGTAA |
|
7681 |
TCCCAGTGCT |
TTAGGAGGCT |
GAGGCTGGAG |
GACCACTAGA |
GGCTAGAAAT |
TTGAGACCAG |
CCTGGGCAAC |
ATAGCGAGAC |
|
7761 |
TCCATTTATA |
CAAAAAATGG |
AAAATATGAG |
GCGGGCTTGG |
TGGCACGTGC |
CTGTAGTCCC |
CGCTACTTGG |
GAGGCTGAGG |
|
7841 |
CGGGAGGATT |
GCTTGAGCCT |
GGGAGGTCGC |
GGCTGCAGTG |
AGCTATGATT |
GCACCACTGC |
ATTCCAGCCT |
GGATGCTGGA |
|
7921 |
GAAAGACCCT |
GTCTCTGAAA |
AAAATCAAAA |
CAAAATGAAG |
GCCCATGAAT |
AGGAATAAGG |
AGATAAATTC |
AGGTCCAAAG |
|
8001 |
AAAGAAGCCT |
TTGTCCACAA |
TTGGAGCTCT |
CCCGCACAGC |
GTAGGAGCCT |
TAGAGGCAGT |
GAGCTACCCA |
TCTTTGAAAG |
|
8081 |
TGTTCAAAGG |
TAGAGGTGTT |
CCCTGGGAAA |
AGTGGCCTAG |
ATGGTCCCTG |
GGGACCTTCC |
CAGCCAGTAG |
GGTTTTCTGA |
|
8161 |
CCCTGCCTTC |
ATCCTACTCC |
TAGCTATTTC |
TTGTTGCTCA |
CATCTCCTGA |
GGCCCAGGAC |
CCTGGAGGGG |
AAGAAGAAGC |
|
8241 |
AGAGAGCGCA |
GCCCGGCAGC |
CCCTCATAAG |
AACCGAGGCC |
CCGGAGTCGA |
AGCCAGGTAG |
GAGACACAGA |
CCCTCAGAGA |
|
8321 |
GGTCACTTTC |
TTTCTCTCTG |
GGTTTGGCCT |
TTTCCTCTCT |
GCAATAGGCA |
AAGTTAAGAG |
GGGAAAGAGA |
GTGAGTGTAC |
|
8401 |
TGGTTATGGG |
AAAAGCCTTT |
GTCTATTTGA |
GAAATACTTG |
TTGAGGACGA |
GCACAGTGGC |
TCACGCCTGT |
AATATCCCAG |
|
8481 |
CACTTTGGGA |
GGCTGAGGCA |
GGAGGACCAC |
TTGAGCTCAG |
AAGTCTGAGT |
CCAGCCTGGG |
CAACAGAGCA |
AGACCTTGTC |
|
8561 |
GCAAAAAAAA |
AAAAAAAAAA |
AAAAAAAAGA |
AAAGAAAGGA |
AGGAAGGGAG |
GGAGAGAAGA |
AGGGATATTA |
ATTGAGTACT |
|
8641 |
TACCATGTGC |
CAGGCATTCC |
AATCACAAGT |
GCTGAGGCCC |
TGCGGTGGGG |
ATAAGCTGGG |
ATGTTCTAGA |
ACCAGAGAAT |
|
8721 |
GGCCAGTGAG |
ACTGGGCAGG |
GTGGGCCAAT |
GGCCATCTGT |
GGAGCTGTAC |
AAGAGACATT |
GGCCGGGCGT |
GGTGGTTCAT |
|
8801 |
ACCTGTAATC |
CCAGCACTTT |
GGGAGGCTGA |
GGCAGATGGA |
TCATTTGAGA |
TCAAGAGTTT |
GAGACCAGTC |
TGGCCAACAT |
|
8881 |
GGTAAAACCC |
CGTCTCTACT |
AAAAATAAAA |
AAATTAGCCA |
GGTGTGGTGG |
TGCATGCCTG |
TAGTCCCAGC |
TACTTGGGAA |
|
8961 |
GCTGAGGCAC |
GAGAATCACT |
TGAACCCAGG |
AGGCAGAGGC |
TGCAGTGAGC |
TGAGATTGCA |
CCACTGCACT |
GCAGCCTGGG |
|
9041 |
CAACTGAGTG |
AGACTCTGTC |
TCAAAAAATA |
AAAAAAATTA |
AAAATCAAAG |
AGACGTGAAG |
AGGTCTCACC |
TGGTTAGCTT |
|
9121 |
TTATTTTCAT |
CATGATAAAG |
TATGTATATT |
ACTTGAAGTT |
TACCATTTTA |
TTATTTTTTA |
TCTTACTTTA |
TTTTTTTGAG |
|
9201 |
GTGGAGTTTC |
GCTCTTGTTG |
CCCAGGCTGG |
AGTGCAATGG |
CGCAATCTCA |
GCTCACTACA |
ACCTCTGCCT |
CCTGGGTTCA |
|
9281 |
AGTGATTCTC |
CTGCCTCAGC |
CACCCGAGTA |
GCTGGGACTA |
CAGACACCTG |
CCACCACACA |
TGGCTAATTT |
TTGTATTTTT |
|
9361 |
AGTAGAGATG |
GGGTTTCTCC |
ATGTTGGCCA |
GGGTGGTCTT |
GAACTCCTGA |
CCTCAGGTGA |
TCCGCCCACC |
TCAGTCTCCC |
|
9441 |
AAGGTGCTGG |
GATTACAAGC |
ATGAGCCACT |
GCGCCCAGCC |
ATTTTAACCA |
TTTTTAAGTG |
TCCAATCCAG |
TGGCATGGAA |
|
9521 |
GTGAGTTCCC |
ACTGTTGCGT |
GGTCTGGTTA |
ATTCTGTCAT |
ACCGGTGCCT |
CTTTGCCGAG |
TCTTCAGTGT |
GAAAACTTCA |
|
9601 |
TCTGCCCTTC |
TCTCTCTGTT |
CCCCTGCAGG |
CTCCAGCTCC |
AGCCTCTCCC |
TTCGGGAAAG |
GTGGACAGTG |
TTCAAGGTTC |
|
9681 |
GGATGATGGC |
TGGGGTATGT |
CCCTGTGGGG |
CTTGCTCACC |
TCCAGGCCCC |
CCGCTTATAT |
CTTCTGCCTT |
TTCCAGGGTC |
|
9761 |
TGCTGTGGTA |
CATTGTTCCC |
TTGGTCGTAG |
TTTACTTTGC |
CGAGTATTTC |
ATTAACCAGG |
GACTTGTAAG |
TGAGGGGTGC |
|
9841 |
TAGGAGGGGT |
GTGGAGGTGG |
CGATTGGGGC |
TGGGACCCAC |
ACAGCCCCGT |
CCATCTCCCC |
TGTCTGGTAT |
TTGTTGCAGT |
|
9921 |
TTGAACTCCT |
CTTTTTCTGG |
AACACTTCCC |
TGAGTCACGC |
TCAGCAATAC |
CGCTGGTAAG |
AGGAGCGAGG |
GCAGTGGGCT |
|
10001 |
GGGAGGGCGC |
CGTGGTGATG |
CAGCTGCCCT |
GCCCAGTAGG |
CACCGGGGGG |
AGCGGGATGG |
TCCCTGGAGG |
AGCCTCCTCT |
|
10081 |
CCTCCCCCCA |
ACCCTAACCT |
CAGGTACCAG |
ATGCTGTACC |
AGGCTGGCGT |
CTTTGCCTCC |
CGCTCTTCTC |
TCCGCTGCTG |
|
10161 |
TCGCATCCGT |
TTCACCTGGG |
CCCTGGCCCT |
GCTGCAGGTA |
CCAAACCCCT |
GCCCCTCACT |
TCACTCCCAC |
CTTGGCTCCC |
|
10241 |
AGCTTGGCTC |
CCAGCTTCCC |
CAAACCCCCT |
GCTTCCCACT |
ATCAGTGGGA |
AGTGTAAATT |
TTTTTTTTTT |
TTTTTGAGAC |
|
10321 |
AGAGTCTCGC |
TCTGTCGTCC |
AGGCTGGAGT |
GCAGTAGCGC |
AATCTTGGCT |
TACTGCAACC |
TCTGCCTCCC |
GGGTTCAAGT |
|
10401 |
GACTCTCCTG |
CCTCAGTCTC |
CTGAGTAGCT |
GGGATTACAG |
GCGCCCGCCA |
CCATACCTGG |
CTAATTTTTG |
TATTTTTAGT |
|
10481 |
AGAGATGGGA |
TTTTGCCATA |
TTGGCTGGTC |
TTGAACTCTT |
GACCTCAGGT |
GATCTGCCGG |
CCTCAGCCTC |
CCAAAGTGCT |
|
10561 |
GGGATTACAG |
GGAAGTGTAA |
ATTGTACACT |
ATCATTTCTT |
AGCACAGGGA |
ACCAAAGTCC |
AGCAGAGCTC |
CATGTAAAAT |
|
10641 |
GTATAGCCTC |
AGGAGCCAAG |
CAAAACTGAG |
CTTCAGTACT |
CAGCCACTGT |
GTGACTTAGG |
GCAGGTCTCA |
GAACCTCTCT |
|
10721 |
GAGCCTCAAT |
TTCCTCATGT |
ATAAATTGGG |
TGTGGCCAAT |
ACCTATTTTT |
CAGGGTAGTT |
GTAAGAAATA |
GAGATGAGAG |
|
10801 |
AAAGAATCGA |
AGAACAAGAT |
TTTGTAGTGT |
GTGTGTGTGT |
GTGTGTGCGT |
GTGTGTGTGT |
GTGTGTGTGT |
GTGTGTGTGT |
|
10881 |
GTGTTTTAAG |
CATTGGGATT |
GGGCCGGGCC |
AGGTGGCTCA |
TGCCTGTAAT |
CCCAGCACTA |
TGGGAGGCTG |
AGGCAGGTGG |
|
10961 |
ATCATTTGAG |
CTTGGTAGTT |
CAAGTCCAGC |
CTGGGCAACA |
TGGCACAATC |
ACATCTCTAC |
AAAAATTAGC |
CAGGTGCAGT |
|
11041 |
GGCGCACACC |
TGTAGTCTTA |
GCTACTGGGA |
AGCTGAGGTG |
GGAGGATCAC |
TTGAACCCAT |
GAGGTCAAGG |
CTGCAGTAAC |
|
11121 |
CAAGGTCATG |
CCACTGCACT |
CCAGCCTAGG |
CAATAGAGCG |
AGACCCTGTC |
TCCCAGAAAA |
AGAAAAAAGA |
AAGGAAAAGT |
|
11201 |
CGGAACCTTC |
CTCTGTCGCC |
TAGGCTGGAG |
TACAGTGGCA |
TGATCATAGG |
TCATTTACCT |
CAGGCAAAGA |
GACAGGCTTT |
|
11281 |
CAAATAATGT |
TTCTAACTAT |
AAGAAAATGT |
ACAGTTCTTT |
TATTCTAGAT |
AGTTAATTAT |
AATAGAATTG |
GTGACTTTGA |
|
11361 |
AGTCAGTGGG |
TTATTTATCT |
TGAGGGTGGT |
GAGCAAATTC |
AACTGCCCTT |
GGCAAACAGT |
AGTTTACAGC |
TTTAAGGGCG |
|
11441 |
CAAACACCCT |
TCCTTACAAC |
AGTCTAATAA |
AAGGAGTTTC |
ATATAACCAG |
CATTCATTGT |
TTCAAGGTTA |
CAAATCCACA |
|
11521 |
GCCCCTGCAG |
GTAACTGTTA |
CAATAAACTG |
TCAACTGTGA |
CAGGAAAGTC |
TTCTGCCTTT |
GAAATTTAGG |
AACTTGGCCA |
|
11601 |
GTCCTGGTGG |
CTCACACCTG |
TAATCCCAGC |
ACTTTGGGAG |
GCCAAGGCAG |
GTGAATCACC |
TGAGGTCAGG |
ATCAGGAGTT |
|
11681 |
TGAGACCAGT |
CTGGCCAACA |
CAGTGAAACC |
CCGTCTCTAT |
TAAAAATGCA |
AAAATTAGTT |
GGGCGTGGTG |
GCACCTGCCT |
|
11761 |
GTCATCTCAG |
CTACTCGCTA |
GGCTGAGGCA |
GGAGAATTGC |
TTGAACTCCG |
GATATGGAGG |
TTGCAGTGAG |
CCGAGATTGC |
|
11841 |
AGTACTGTAC |
TCCAGCCTGG |
GCCACAGAGC |
GAGACTCCAT |
CTCCAAAAAA |
AAAGACTTAG |
GAACTCAATT |
CTGTGATAGC |
|
11921 |
AAAATACAGA |
AATAGAGATT |
ATACTTTAGG |
CTAGGTGTTG |
TGGCTCACAC |
CTGTAATCCC |
AATGCTTTTG |
GAGGCTAGGG |
|
12001 |
TGGGAGGATC |
ACTCGAAGCC |
AGGAGCTTGA |
GACCAGACTG |
GACAACATAG |
TGAGACCCCC |
CACCTCTACA |
AAAAATTAAA |
|
12081 |
AAAAAAAATA |
AGCCAGGTGG |
GAGAATTGCT |
TGAGCCCAGA |
AGTTTGAGAG |
AGCAGCCTGG |
GTAACATCAC |
GAGACCTCAT |
|
12161 |
CTCTACAAAA |
AACAACAACA |
GGGTGTGGTG |
ACATTCACCT |
GTAATCCCAG |
CTACTCGGGA |
GGCTGAGGCA |
GGAGGATCGC |
|
12241 |
TTTAGCCCAG |
GAGTTCCAGG |
CTGCAGTGAG |
CCATAATCAT |
GCCACTGTAC |
CCCAGCCTGG |
GTGAGACCCT |
ATCTCAAAAA |
|
12321 |
AAAAGATTAC |
ACTTTCATAT |
TATGGCAAAA |
GCATGTAAAT |
ATCCTCCAGC |
CTCCTTCCTT |
ATTTATCTGA |
GCAGTGCTGC |
|
12401 |
AAGCCCAGGG |
TTTGTACCCA |
CAAAACCCCA |
AATTTATAAC |
TCAGGGTGCT |
TGTAGATACC |
ACTGAAACAT |
GTAGCTTATG |
|
12481 |
GTTTTAAGCT |
ACATGTTTTT |
AGCTATAATG |
TTTTTTGTTT |
TGTTTTGTTT |
TTTGAGATGG |
AGTCTCGCTC |
TGTTGCCCAG |
|
12561 |
GCTGGAATGT |
AGCGGTGCAA |
TCTTGGCTCA |
CTGCAACCCC |
TGCCTCCCAG |
ATTCAAGCGA |
TTCTCAAGCC |
TCAGCCTTCC |
|
12641 |
GAGTAGCTGG |
GATTACAGGT |
GCGCCACCAC |
GCCCAGCAAA |
TTTTTTGTTT |
TGTTTTGTTT |
TGTTTTGTTT |
TTTAGAGACA |
|
12721 |
GAGTTTTGCT |
CTTGTAGCTC |
AGGCTAGAGT |
ACAATGGCGT |
GATCTTGGCT |
CACTGCAACC |
TCCGCCTCCC |
AGGTTCAGGC |
|
12801 |
GATTCTTCTG |
CCTCAGCCTC |
CTGCGTAGCT |
GGGATTACAG |
GCACGTGCCA |
CCACACCTGG |
CTAATTTTTG |
TATTTTTTAG |
|
12881 |
TAGAGATGGG |
GTTTCGCCAT |
GTTGGCCAGG |
CTGGTCTTGA |
ACTCCTGACC |
TCAGGTGATC |
CACCCGCCTT |
GGCCTTCCAA |
|
12961 |
AGTGCTGGGA |
TTACAGGTGT |
GAGCCACCAC |
ACCTGGCTAG |
AGGTGTGTCC |
TTTTTAATGC |
TCATCTTTAA |
GTCTACCTCA |
|
13041 |
GATTTAATGA |
ATTAGGACCT |
CTAGGGTAAG |
CCCCGCTTGG |
GGCATTTGTA |
CCTAGATCCC |
CAGGCAATTC |
TTACATATAC |
|
13121 |
GAAAAGTATG |
AACCGCCACG |
AGGAGGCCTA |
CACACTGCAC |
AAGAGGCAAT |
GTGGCGTGGT |
CAGTGCTGGG |
AGGATGGCAC |
|
13201 |
CTCCTTGAGA |
GACTGGGGCA |
CAGAGGTGGG |
ACCTACACCC |
TGGGGTGGGG |
ATCGAAGAGG |
CTTCCTGGCC |
AGGTGCGGTG |
|
13281 |
GCTCCTGCCT |
ATAATCCCAG |
CACTTTGGGA |
GGCTGAGGCA |
GGGGGGCAGC |
GACTGCTTGA |
GACCAGGAGT |
TCGAGCCCAG |
|
13361 |
CTGAATAGGA |
TGCCCGGCTA |
CTCCCACCTT |
GTTTTACCAT |
AGTGAACCAA |
CGGTTTTTCC |
AATAGGGGCA |
ATTTTGCTGC |
|
13441 |
CCAGCGGATG |
TTTGGCAACG |
TCTGCAGGCA |
TGCTTTGGTT |
GTCACAACTG |
AGGGATGCTA |
TGGGCATCTA |
GCGGGCAGAG |
|
13521 |
GCCAGGGATC |
CTGCTAAATG |
CGCTGCCATA |
TACAGGACAG |
CCCTCACCAT |
GCAGAACAAC |
CAGCACCAAA |
CGCCAAGAGT |
|
13601 |
GCTGCAATTG |
AGAAATCCTG |
GTTTCGATGG |
TCCCACTTCC |
TTTAAGAAGC |
CTCCATTTTT |
TTTTTTTTTT |
TTTTTTTTTT |
|
13681 |
TTTTATGAGA |
CAGGATCTTG |
CTCTGTCACC |
CAGGCTGGAG |
TGCAGTGGCA |
CAATCATAGC |
TTACTGCAGC |
CTCCACCTCC |
|
13761 |
TAGGTTCAAG |
CAATCCTCCT |
GTCTCAGACT |
CCCGAGTAGC |
TGGGACTGCA |
GGTGCGTGCC |
ACCATGCTCA |
ACTAATTTTT |
|
13841 |
AAATTTTTTG |
TAGAGACGGA |
GTTTTGTTAT |
GTTGCCCAGG |
CTGGTCTCGA |
ACTCCTGGCC |
TCAAGTGATC |
ATCCCACCTT |
|
13921 |
GGTCTCCCAA |
TGTGCTGGTA |
TTACCTGCAT |
GAGCCACTGC |
ACCAGGCTGA |
GGTTGAGAAT |
TTTTTTTTTT |
TTTTTTTGGG |
|
14001 |
ATGGAGTCTC |
TCTCTGTTGC |
CCAGGCTGGA |
GTGCAGTGCT |
GCGATCTTGG |
CTCACTGCAG |
CCTCTGCCTC |
CCAGGTTCAA |
|
14081 |
GTGATTCTCC |
TGCCTCAGCC |
TTCCAAGTAG |
CTGGGACTAC |
AGAACCACTA |
CACCCAGATA |
ATTTTTGTAT |
TTTTAGTTGA |
|
14161 |
GATGGGGTTT |
TACCATGTTT |
AGTAGAGACC |
AGGCCAGGCT |
GGTCTCGAAA |
TCCTGACCTC |
AGGTGATCTG |
CCCACCTCAG |
|
14241 |
CCTCCCAAAG |
TGCTGGGATT |
ACAGGTGTGA |
GCCACCACAC |
CGGGCTGGTG |
TTGAGATTTT |
ATCTAGACCT |
GGCAGCCCTC |
|
14321 |
TCCTTCACCA |
GTAACTCCTA |
AAACCAGGGA |
CCCCTGGAGG |
GGAGGCCACC |
TCTCCTTCCC |
TGCCCCGCCC |
TGGTCCCAGG |
|
14401 |
CTTAGCCTCT |
CCCCCTGTTC |
ACAGTGCCTC |
AACCTGGTGT |
TCCTGCTGGC |
AGACGTGTGG |
TTCGGCTTTC |
TGCCAAGCAT |
|
14481 |
CTACCTCGTC |
TTCCTGATCA |
TTCTGTATGA |
GGGGCTCCTG |
GGAGGCGCAG |
CCTACGTGAA |
CACCTTCCAC |
AACATCGCCC |
|
14561 |
TGGAGGTCAG |
CATTGGCCGG |
GCAAGGGCTG |
GGGGTGGCCT |
GTCCAGGGAC |
ACCCAGGGCA |
GGGATGTCTG |
GGACTGAAGC |
|
14641 |
CTCACCCCTG |
CTCTCTGCCC |
TCCCAGACCA |
GTGATGAGCA |
CCGGGAGTTT |
GCAATGGCGG |
CCACCTGCAT |
CTCTGACACA |
|
14721 |
CTGGGGATCT |
CCCTGTCGGG |
GCTCCTGGCT |
TTGCCTCTGC |
ATGACTTCCT |
CTGCCAGCTC |
TCCTGATACT |
CGGGATCCTC |
|
14801 |
AGGACGCAGG |
TCACATTCAC |
CTGTGGGCAG |
AGGGACAGGT |
CAGACACCCA |
GGCCCACCCC |
AGAGACCCTC |
CATGAACTGT |
|
14881 |
GCTCCCAGCC |
TTCCCGGCAG |
GTCTGGGAGT |
AGGGAAGGGC |
TGAAGCCTTG |
TTTCCCTTGC |
AGGGGGGCCA |
GCCATTGTCT |
|
14961 |
CCCACTTGGG |
GAGTTTCTTC |
CTGGCATCAT |
GCCTTCTGAA |
TAAATGCCGA |
TTTTATCCAT |
GGAC |
|
|
|
|
|
|
|
|
|
|
|
|
>ref|Gene_ID:1201|CLN3|NC_000016.9:28488599...28503622 (-)
TAACTGGTGCTGGCAGGCTACTGTCTCGGTCTTGGGCGCCACTGATCTAAGGTCACGGCTCTGCTTGCTGCTCCCACCCG
CTCCAGTTTAAAACCTGCGGTTCCAGGGTTCTCCAGCCCCTCCCTTTTTCACGCTCCGAAGCCGAGAAGGCCCAAAGCGA
AGACAGAGAGGACCCGGAAGTAGGGAAAACCTCTGAGCACGTGATGGGGGAACACGCGGGTGCTGTCACGTGATCCGACA
AACGGCCTCTGCATAGTGCAGAACATTCTGCTGCTCTTAAAGGTACAGGCCTCAGGGTCCCTGCTGTAGACGGGGCGGGG
GAGAGTACGATGGGTGGGGCGTGGTGGGTCGTAGGGCGCTCGAGATGGAGCCCCCAGCTTCCTTGATGGATCGCGGGGCG
CGAGTGCCCTAGACAAGCCGGAGCTGGGACCGGCAATCGGGCGTTGATCCTTGTCACCTGTCGCAGACCCTCATCCCTCC
CGTGGGAGCCCCCTTTGGACACTCTATGACCCTGGACCCTCGGGGGACCTGAACTTGATGCGATGGGAGGCTGTGCAGGC
TCGCGGCGGCGCTTTTCGGATTCCGAGGGTGAGTATTCCCGCCCACCCTCATGGAACGACCACCTCTGGCTCGCAGCCCA
CCTGAGGGGAATGAGAGCTGACTCGGCCCCGGGAGGACACGCAAGGAGCGGTCGTGCACCTGAGAGTAGGTGGGGGTCAT
GCCCTCTTCTCGCTCTCCCAGGGGAGGAGACCGTCCCGGAGCCCCGGCTCCCTCTGTTGGACCATCAGGGCGCGCATTGG
AAGAACGCGGTGGGCTTCTGGTGAGTGGCCTGAGACTTCAGCGAGTGACAATGGCATGAGAAGAGGGAAGTGACCGGAGG
AAAGGGGGAAGAAAGAGTTAAGCTGCGCAAAGGAGCTGAACCCACAAATATTTACTGAATCCACTGGTTTGCCCCAGGGG
CAGCATGTAAAATTTCCAAACTTCACTCCTTATCACCTTCCGGATTTAGCAAGATCCTCATACCTACCACCTGTAGGATT
ATTTACTTTTTTCTTCCAGCCAATTCAGCCTTAACGTTTTTTAGTGCACATATTTTTAAAAAGAAAACTTTAAATCACGA
CTCCACTTGGAAAACCAGCGTTTTCCTAGTGAACGTTTAAATAAATGCATCACTACTAAAACTTTTTTATTTTTTTAATT
TATTTTATTTTATCTTATTTTTTTTTCTTTTTGAGACAGGGTCTTGCTCTGTTTCCCAGGTTGGAATGCAGTAGTGCAAT
CACAGCTCCCTGCAGCCTGGAACTCCTGGGCTCAAGTGATTCTCCCACCTCAGCCTCCAAGTAGGTGTGGCTACAGGTGT
GCACCACCGCATCTGCCTAATTTTTATATTTTTTTATAGAGATGGGGGTCTCACTATGGGACCTGGGCTGGTCTCAAACT
CGTGGCCTCAAGTGATCCTCCTACCTCAACCTTCCAAAGTGCTGAGATTACAAGCATGAGCCACCATGCCGGGCCTGAAC
CTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCTCTCTGTCCTCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCAC
TGCAAACTCCGCCTCCCAGGTTCACACCATTCTTTTGCCTCAGCCTCCGGAGTAGCTGAGACTACAGGCGCCTGCCACCA
CGCCCGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGCGTTATCCAGGATGGTCTCGATCTCCTGACCTCG
TGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCAGCTTTTTTTTTTTTTTTTTT
TAATTTTATTTTATTTTTGAGACAGAGTCTCACTCTATCACCCAGGCTGGAGAGCAGTGGCACAATCTCGGCTCACTGAA
ACCTCCACCTCCAAGGTTCAAGCTATTCTCCTGTCTCAGCTCCCCGAGTAGCTGGGATTACAGGTGCGTGCCACCAGACA
CAGCTAATTTTTTGTATTTTTAGTAAAGACAGGATTTCACCATGTTGGTCAGGCTGGTCTAGAACTCCTGACCTTAGGTG
ATCCGCTTGCCTCCACTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCCGCCCTGACATAGGGGCTTTGGG
ATCACAGACTTGGATTCACTTCCAGCCTCCAAGGCCTCTCCCAGAAACTCTCTGTGACCACTCTCCTTTTTTTTTTTTTT
TTTTGAGATAGAGTCTCGCTCTTGTAGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTTACTGCAACCTCCGCCTTTC
GGGTTCAAGTGGTTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGATTACAGGCATGTGCAACTTCGCCCAGCTAATTTTGT
ATTTTTTAGTAGAGACGGGGTTTCTCCATATTGCTCAGGCTGGTCTCGAACTCCTGACCTCAGGCGATCCGCCCGCCTCG
GCCCCTCAAAGTGCTGGAATTACAGGTGTGAGCCACTGCACTCGGCCTCTTCCTTTTTATTTTTTATTTTTGTGACAGGG
TCTTGCTCTGTCACCCAGGCTAGAGTGCAGTGGCATGATCACAGTTCACTGCAGCCTCTGACTCCTGGACTCAAGCAATC
CTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAGTGCAAGCCACCACACCTGGCTAATTTTTAAATTTTTTGTAGAGA
TGGGGGTCTCACTATCTTGCCCAAGCACCAAAGCCTGTATTTTTGACCCCAACATTGAATGAGGATGGGATCTGGTGATA
GAGGGAAAAAAAAGAGGGGGCTGATTGAAGGGCACAGGTAAGGGAAGGTTTGGCACAAAGGCTACAGATGGCTGCAGGAT
GAGGAGGGAGTTGAGACCTGTCCTGCTCCTTCCAGGCTGCTGGGCCTTTGCAACAACTTCTCTTATGTGGTGATGCTGAG
TGCCGCCCACGACATCCTTAGCCACAAGAGGACATCGGGAAACCAGAGCCATGTAAGTGACTCTCTACCACCACCACCAT
GGTTAGTCCCTGTGGGAAGATGAGGGGGTGGGACAAGGTGGGGTAAAGTTTCCAGTCTCTGGCTGGGCACAGTGGCTCAC
ACCTGTAATCCCAGCAGTTTGGGAGGCTGAGGCGGGCGGATCACTTGAAGTCAGGAGTTCGAGACCAGCCTGGCCAACAT
GGTGAAACTCCGACTCTACTAAAAATACAAAAACTACCTGGGTGTGGTGGCACACACCTGTAGTCTGAGCTATTCAGGAG
GCTGAGGCAGGAGAATTGCTTGAAGCCAGGAGGTGGAAGTTGCAATGAGCCAAGATCACACCACTGCACTCTAGCTTGGG
CAACAGAGTGAGACACCATCTCAAAAAAAAGAAAGCTCTTGAATGTGTTATCTAAACAAAGTCCATTTACAGGGCCATCT
GTGGCCTGTGGTCTAGTAGTGTGAGACTCATATGGAAACCCCCTCTTCATTGTGCATGCAGAGACGCTGAGGTCCTGAGA
AGTCAGTCACTGCTGACCCAAAGCCATCCTTCAAGTGAAGGCAGAGCTGGGACGGGAGCCAGGCTCTGTGTGTCTATCCC
TCTGCCTCCAGGGTGAAAGACATGCTTTTCTCCCATTAGGTGGACCCAGGCCCAACGCCGATCCCCCACAACAGCTCATC
ACGATTTGACTGCAACTCTGTCTCTACGGCTGTGCGTACTCATCTCACCTGGTCCTTGCCTGACCCAGGGCCCCTGGGTC
TATAGACCCCACTCCCAGCCCTTCACTACCCAGCTGGGACTGTCATGATTAAAACAGTTGAGACCTGGGCTGGGCGCACT
GGCTCACACTTGTAATCCCAGCACTTTGGGAGACCAAGGTGGGAGGATCACTTGAGCCTAGGAGTTTGAGACCAGCCTGG
GCAGTATAGTGAGACCCCCATCTTAAAGAAAAAAATTAAAAAATATATATATATAAAATAATTGAGACCTTAATATAATT
TCTGAGGCTGAGGCGGATGGATCACTTGAGACCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTGTAC
TAAAAATACAAAAATTAGCCAGGCATGGTGGTGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCAC
TTGAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAGATCGAGCCACTACACTCCAGCCTGGGTGGCAGAATGAGACTCACT
CTCAAAATATATATATATATAGTTTCTGAGTCCTTTCTGTCTGCACCATATATTAGCTCATTTAAGCCACACAGCAGTCC
TGTGAGCTAGGTGCTATGATATTCCCATTTTCCAGATGAGGAAACTGAAGCTCAGAGAGTATAAACTCTTGACACACAAC
TAAGGAGTGGGAGAGCTGAGACTTGAACCCAGGCGTGCCTGACTCCAGAGCCTGTGTTTGTAGCAGGCCTGTTTGGCCAG
CTCCTGCCTCTCCTTGGCCACGTGGTTGGGAGGGTTGTCCCCTGGAAGCTCTGCGGTCTCACTCTATTCTCCTGTCCCAG
GCTGTGCTCCTGGCGGACATCCTCCCCACACTCGTCATCAAATTGTTGGCTCCTCTTGGCCTTCACCTGCTGCCCTACAG
GTCTGGGTGAGGGTAGTGGGAGGCAGGGTGGGCAGGAGCTGAGAAAGGGGAGGCTGGGATGGCTGAGATGCTGAGAGTAG
AGACCGACCTTCCCCCTCCCTTCCCTTCTCACCCCCTCAGCCCCCGGGTTCTCGTCAGTGGGATTTGTGCTGCTGGAAGC
TTCGTCCTGGTTGCCTTTTCTCATTCTGTGGGGACCAGCCTGTGTGGTGAGTGTGTGGTTCTGTGTCAGATGGGGAGCCC
CGAGGAACCACATCAGAGCATTTGTGGGAAGAGTCTCCCCAGCCTCCCAGAGGAAAGGGATTCATTCTGTCACCCTTAGA
AGCCTGCTAGGGCTATCAGCAGTAGGCGATGGGAGACTGGGACAATTTGGAGGGGTAGGCAGTGGAGGAGATGGGAGAAA
ATGGATGAATTAGATGGAGATTGAGGTGAACAAAGTCAAGACTCTGTGATGGACCAGGCACAGTGACTCATGCCTATAAT
CCCAGCACTTTGGAAAGCCAAGGCAGGCAGATCACCTGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGAGAAACC
CCGTCTCTACCAAAAATACAAAAATTAGCTGGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCA
GGAGAATCTCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACGCCACTGTACTCCAGCCTGGGTGACAGGGC
GAGACTCCGTCTCCAAAAAGAAAAGAAAAGAAAAAGACTGATGAAGGGGCAGAGACATCAAGGGTGCATGTCTGCCCCTG
GTCTGATAACTGGGTGGATGGAGGTGCCACTCTCCATGAAGGGACACGCAGGGGAGTGGGGCTCTGCTTCAGACCTGGAA
CCTGGCCTATGCATGGGATCTATTGGAGCCTCTATGAGCTGATACTGAGGAGGCCATGGCCAGACACATTAGAGGCCTGG
GCAGTGTGGCAAGGTGTGGTGTGACCATCCCAGTGCTTGTCCTCCCCCCAGGTGTGGTCTTCGCTAGCATCTCATCAGGC
CTTGGGGAGGTCACCTTCCTCTCCCTCACTGCCTTCTACCCCAGGTAAGCAGGTGGAGCAGGGAGTGTGGGGAGAGGCTG
TCCCATGGTCAGCCTAGGTCCTCCTGAATGTTCCTGTGTTCTCCTTCCCAGGGCCGTGATCTCCTGGTGGTCCTCAGGGA
CTGGGGGAGCTGGGCTGCTGGGGGCCCTGTCCTACCTGGGCCTCACCCAGGCCGGCCTCTCCCCTCAGCAGACCCTGCTG
TCCATGCTGGGTATCCCTGCCCTGCTGCTGGCCAGGTGAGCTGCCCTGAGCCGGGAGGGAGAGGGGTCCAAGGAGAGAAA
ACTTGGCCATGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGAGGGCAGATCGCCTAAGG
TCAGGAAACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAACAATTAGCCAGGTGTGGTGGCGGGTG
CCTGTAGTCCCAACTACTCAGGAGGCTAAGGCAGGAGAATCGCTTGAACCCCGGAGGCAGTGGTGGCAGTGAGCCGAGAT
CGTGCCATTGCACTCCAGCCCGGGCGACAGAGTTAGACTCTGTCTCAGGAAGAAAAAAAAAAAAAGAAAGAAAAGAAAAC
TTGATTATGATTGCAATCTTCAAGTCCCTACCTTGCTGTGAAGGGAGGCGGAATCTGGACTCTGATAGCCCCAGGTGTGA
GTCCTGGAGCTGCCACTTTTTAGCTTTGTAGCGTTGAACAAGTTACTCCACCTCTCTGAACCCTCAGTTTCCCCATATCT
CAAATGGCAGTTGTTCTTGCTTTCCTTGGAGGTGATGAGGGTAATGCATTCAGCACAGTGTGGTTCCCAAGGTGATTAGA
AGTAGGATGAGGGTGGACTTTATTTGATTAGTTCCTTTTTTTTTTTTTTTTTTTTTTAATCAGTGTTGACCAGGTTGGCC
TCGAATGTGTAGCCTTGCCTGCCTGAGTGCCAGGGCAACAGGCCTGAACCATGGCGACTCCCTTTTTTTTTTTTTTTTTT
TTTTTTTTTTGAGACGGAGTCTCATGGTGTCACTCAGGCTGGAGTGCAGTGACTGGTGTGATCTCAGCTCACTGCAGCCT
CGGCCTCCCGGGCTCTAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCCCATGCCACCATGCCTGGC
TAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACTGTATTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCC
ACCTGCCTTGGCCTCCCATAATGCTAGGAATACAGGCGTGAGCCACCGCGCCCGGCCTGATTAGTTCTGTGTATTTTCAT
GCATATTACAAAACACTTTGGCCGGGCATGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGCAC
CACGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGC
TTGGTGGCGCTTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGAGAAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCA
GTGAGCCGTGATTGTGCCACTGCACTCCAGGCTGGGCAACAGAGCGAGACTCCGTCTAAAAAAAAAAAAAACACACACTT
TGAACTAGCCAGACACACCTGGCCCTTCACAAGATTAGTGCTTAGGACAAGTCTAAGTAGAAAAAGTGAGTCCATTTAAA
GAAAAATATTAAGTAAAAATATATATATACAGGAGGAATATGGATATGGCAAATAACATGAAGCCAGAACCTAAGTGACT
AAAATCGAGGAAGTTCTGGCCTAGCACAGAGTGAACGTATAATTAATGGGAGCTAGAGCGACCATTAGAATAATAATGGC
CAGAAAACAGAACTGACTCGCTAGGTATGAGCCAGCAGTCCGAACAAGGGCCTGCTGAGCACAGTGGCTCACAGCTGTAA
TCCCAGTGCTTTAGGAGGCTGAGGCTGGAGGACCACTAGAGGCTAGAAATTTGAGACCAGCCTGGGCAACATAGCGAGAC
TCCATTTATACAAAAAATGGAAAATATGAGGCGGGCTTGGTGGCACGTGCCTGTAGTCCCCGCTACTTGGGAGGCTGAGG
CGGGAGGATTGCTTGAGCCTGGGAGGTCGCGGCTGCAGTGAGCTATGATTGCACCACTGCATTCCAGCCTGGATGCTGGA
GAAAGACCCTGTCTCTGAAAAAAATCAAAACAAAATGAAGGCCCATGAATAGGAATAAGGAGATAAATTCAGGTCCAAAG
AAAGAAGCCTTTGTCCACAATTGGAGCTCTCCCGCACAGCGTAGGAGCCTTAGAGGCAGTGAGCTACCCATCTTTGAAAG
TGTTCAAAGGTAGAGGTGTTCCCTGGGAAAAGTGGCCTAGATGGTCCCTGGGGACCTTCCCAGCCAGTAGGGTTTTCTGA
CCCTGCCTTCATCCTACTCCTAGCTATTTCTTGTTGCTCACATCTCCTGAGGCCCAGGACCCTGGAGGGGAAGAAGAAGC
AGAGAGCGCAGCCCGGCAGCCCCTCATAAGAACCGAGGCCCCGGAGTCGAAGCCAGGTAGGAGACACAGACCCTCAGAGA
GGTCACTTTCTTTCTCTCTGGGTTTGGCCTTTTCCTCTCTGCAATAGGCAAAGTTAAGAGGGGAAAGAGAGTGAGTGTAC
TGGTTATGGGAAAAGCCTTTGTCTATTTGAGAAATACTTGTTGAGGACGAGCACAGTGGCTCACGCCTGTAATATCCCAG
CACTTTGGGAGGCTGAGGCAGGAGGACCACTTGAGCTCAGAAGTCTGAGTCCAGCCTGGGCAACAGAGCAAGACCTTGTC
GCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAGGAAGGAAGGGAGGGAGAGAAGAAGGGATATTAATTGAGTACT
TACCATGTGCCAGGCATTCCAATCACAAGTGCTGAGGCCCTGCGGTGGGGATAAGCTGGGATGTTCTAGAACCAGAGAAT
GGCCAGTGAGACTGGGCAGGGTGGGCCAATGGCCATCTGTGGAGCTGTACAAGAGACATTGGCCGGGCGTGGTGGTTCAT
ACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGATGGATCATTTGAGATCAAGAGTTTGAGACCAGTCTGGCCAACAT
GGTAAAACCCCGTCTCTACTAAAAATAAAAAAATTAGCCAGGTGTGGTGGTGCATGCCTGTAGTCCCAGCTACTTGGGAA
GCTGAGGCACGAGAATCACTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCTGAGATTGCACCACTGCACTGCAGCCTGGG
CAACTGAGTGAGACTCTGTCTCAAAAAATAAAAAAAATTAAAAATCAAAGAGACGTGAAGAGGTCTCACCTGGTTAGCTT
TTATTTTCATCATGATAAAGTATGTATATTACTTGAAGTTTACCATTTTATTATTTTTTATCTTACTTTATTTTTTTGAG
GTGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCAATCTCAGCTCACTACAACCTCTGCCTCCTGGGTTCA
AGTGATTCTCCTGCCTCAGCCACCCGAGTAGCTGGGACTACAGACACCTGCCACCACACATGGCTAATTTTTGTATTTTT
AGTAGAGATGGGGTTTCTCCATGTTGGCCAGGGTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCACCTCAGTCTCCC
AAGGTGCTGGGATTACAAGCATGAGCCACTGCGCCCAGCCATTTTAACCATTTTTAAGTGTCCAATCCAGTGGCATGGAA
GTGAGTTCCCACTGTTGCGTGGTCTGGTTAATTCTGTCATACCGGTGCCTCTTTGCCGAGTCTTCAGTGTGAAAACTTCA
TCTGCCCTTCTCTCTCTGTTCCCCTGCAGGCTCCAGCTCCAGCCTCTCCCTTCGGGAAAGGTGGACAGTGTTCAAGGTTC
GGATGATGGCTGGGGTATGTCCCTGTGGGGCTTGCTCACCTCCAGGCCCCCCGCTTATATCTTCTGCCTTTTCCAGGGTC
TGCTGTGGTACATTGTTCCCTTGGTCGTAGTTTACTTTGCCGAGTATTTCATTAACCAGGGACTTGTAAGTGAGGGGTGC
TAGGAGGGGTGTGGAGGTGGCGATTGGGGCTGGGACCCACACAGCCCCGTCCATCTCCCCTGTCTGGTATTTGTTGCAGT
TTGAACTCCTCTTTTTCTGGAACACTTCCCTGAGTCACGCTCAGCAATACCGCTGGTAAGAGGAGCGAGGGCAGTGGGCT
GGGAGGGCGCCGTGGTGATGCAGCTGCCCTGCCCAGTAGGCACCGGGGGGAGCGGGATGGTCCCTGGAGGAGCCTCCTCT
CCTCCCCCCAACCCTAACCTCAGGTACCAGATGCTGTACCAGGCTGGCGTCTTTGCCTCCCGCTCTTCTCTCCGCTGCTG
TCGCATCCGTTTCACCTGGGCCCTGGCCCTGCTGCAGGTACCAAACCCCTGCCCCTCACTTCACTCCCACCTTGGCTCCC
AGCTTGGCTCCCAGCTTCCCCAAACCCCCTGCTTCCCACTATCAGTGGGAAGTGTAAATTTTTTTTTTTTTTTTTGAGAC
AGAGTCTCGCTCTGTCGTCCAGGCTGGAGTGCAGTAGCGCAATCTTGGCTTACTGCAACCTCTGCCTCCCGGGTTCAAGT
GACTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGATTACAGGCGCCCGCCACCATACCTGGCTAATTTTTGTATTTTTAGT
AGAGATGGGATTTTGCCATATTGGCTGGTCTTGAACTCTTGACCTCAGGTGATCTGCCGGCCTCAGCCTCCCAAAGTGCT
GGGATTACAGGGAAGTGTAAATTGTACACTATCATTTCTTAGCACAGGGAACCAAAGTCCAGCAGAGCTCCATGTAAAAT
GTATAGCCTCAGGAGCCAAGCAAAACTGAGCTTCAGTACTCAGCCACTGTGTGACTTAGGGCAGGTCTCAGAACCTCTCT
GAGCCTCAATTTCCTCATGTATAAATTGGGTGTGGCCAATACCTATTTTTCAGGGTAGTTGTAAGAAATAGAGATGAGAG
AAAGAATCGAAGAACAAGATTTTGTAGTGTGTGTGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTTTTAAGCATTGGGATTGGGCCGGGCCAGGTGGCTCATGCCTGTAATCCCAGCACTATGGGAGGCTGAGGCAGGTGG
ATCATTTGAGCTTGGTAGTTCAAGTCCAGCCTGGGCAACATGGCACAATCACATCTCTACAAAAATTAGCCAGGTGCAGT
GGCGCACACCTGTAGTCTTAGCTACTGGGAAGCTGAGGTGGGAGGATCACTTGAACCCATGAGGTCAAGGCTGCAGTAAC
CAAGGTCATGCCACTGCACTCCAGCCTAGGCAATAGAGCGAGACCCTGTCTCCCAGAAAAAGAAAAAAGAAAGGAAAAGT
CGGAACCTTCCTCTGTCGCCTAGGCTGGAGTACAGTGGCATGATCATAGGTCATTTACCTCAGGCAAAGAGACAGGCTTT
CAAATAATGTTTCTAACTATAAGAAAATGTACAGTTCTTTTATTCTAGATAGTTAATTATAATAGAATTGGTGACTTTGA
AGTCAGTGGGTTATTTATCTTGAGGGTGGTGAGCAAATTCAACTGCCCTTGGCAAACAGTAGTTTACAGCTTTAAGGGCG
CAAACACCCTTCCTTACAACAGTCTAATAAAAGGAGTTTCATATAACCAGCATTCATTGTTTCAAGGTTACAAATCCACA
GCCCCTGCAGGTAACTGTTACAATAAACTGTCAACTGTGACAGGAAAGTCTTCTGCCTTTGAAATTTAGGAACTTGGCCA
GTCCTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGAATCACCTGAGGTCAGGATCAGGAGTT
TGAGACCAGTCTGGCCAACACAGTGAAACCCCGTCTCTATTAAAAATGCAAAAATTAGTTGGGCGTGGTGGCACCTGCCT
GTCATCTCAGCTACTCGCTAGGCTGAGGCAGGAGAATTGCTTGAACTCCGGATATGGAGGTTGCAGTGAGCCGAGATTGC
AGTACTGTACTCCAGCCTGGGCCACAGAGCGAGACTCCATCTCCAAAAAAAAAGACTTAGGAACTCAATTCTGTGATAGC
AAAATACAGAAATAGAGATTATACTTTAGGCTAGGTGTTGTGGCTCACACCTGTAATCCCAATGCTTTTGGAGGCTAGGG
TGGGAGGATCACTCGAAGCCAGGAGCTTGAGACCAGACTGGACAACATAGTGAGACCCCCCACCTCTACAAAAAATTAAA
AAAAAAAATAAGCCAGGTGGGAGAATTGCTTGAGCCCAGAAGTTTGAGAGAGCAGCCTGGGTAACATCACGAGACCTCAT
CTCTACAAAAAACAACAACAGGGTGTGGTGACATTCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGGATCGC
TTTAGCCCAGGAGTTCCAGGCTGCAGTGAGCCATAATCATGCCACTGTACCCCAGCCTGGGTGAGACCCTATCTCAAAAA
AAAAGATTACACTTTCATATTATGGCAAAAGCATGTAAATATCCTCCAGCCTCCTTCCTTATTTATCTGAGCAGTGCTGC
AAGCCCAGGGTTTGTACCCACAAAACCCCAAATTTATAACTCAGGGTGCTTGTAGATACCACTGAAACATGTAGCTTATG
GTTTTAAGCTACATGTTTTTAGCTATAATGTTTTTTGTTTTGTTTTGTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAG
GCTGGAATGTAGCGGTGCAATCTTGGCTCACTGCAACCCCTGCCTCCCAGATTCAAGCGATTCTCAAGCCTCAGCCTTCC
GAGTAGCTGGGATTACAGGTGCGCCACCACGCCCAGCAAATTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTTAGAGACA
GAGTTTTGCTCTTGTAGCTCAGGCTAGAGTACAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAGGC
GATTCTTCTGCCTCAGCCTCCTGCGTAGCTGGGATTACAGGCACGTGCCACCACACCTGGCTAATTTTTGTATTTTTTAG
TAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTTGGCCTTCCAA
AGTGCTGGGATTACAGGTGTGAGCCACCACACCTGGCTAGAGGTGTGTCCTTTTTAATGCTCATCTTTAAGTCTACCTCA
GATTTAATGAATTAGGACCTCTAGGGTAAGCCCCGCTTGGGGCATTTGTACCTAGATCCCCAGGCAATTCTTACATATAC
GAAAAGTATGAACCGCCACGAGGAGGCCTACACACTGCACAAGAGGCAATGTGGCGTGGTCAGTGCTGGGAGGATGGCAC
CTCCTTGAGAGACTGGGGCACAGAGGTGGGACCTACACCCTGGGGTGGGGATCGAAGAGGCTTCCTGGCCAGGTGCGGTG
GCTCCTGCCTATAATCCCAGCACTTTGGGAGGCTGAGGCAGGGGGGCAGCGACTGCTTGAGACCAGGAGTTCGAGCCCAG
CTGAATAGGATGCCCGGCTACTCCCACCTTGTTTTACCATAGTGAACCAACGGTTTTTCCAATAGGGGCAATTTTGCTGC
CCAGCGGATGTTTGGCAACGTCTGCAGGCATGCTTTGGTTGTCACAACTGAGGGATGCTATGGGCATCTAGCGGGCAGAG
GCCAGGGATCCTGCTAAATGCGCTGCCATATACAGGACAGCCCTCACCATGCAGAACAACCAGCACCAAACGCCAAGAGT
GCTGCAATTGAGAAATCCTGGTTTCGATGGTCCCACTTCCTTTAAGAAGCCTCCATTTTTTTTTTTTTTTTTTTTTTTTT
TTTTATGAGACAGGATCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTTACTGCAGCCTCCACCTCC
TAGGTTCAAGCAATCCTCCTGTCTCAGACTCCCGAGTAGCTGGGACTGCAGGTGCGTGCCACCATGCTCAACTAATTTTT
AAATTTTTTGTAGAGACGGAGTTTTGTTATGTTGCCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATCATCCCACCTT
GGTCTCCCAATGTGCTGGTATTACCTGCATGAGCCACTGCACCAGGCTGAGGTTGAGAATTTTTTTTTTTTTTTTTTGGG
ATGGAGTCTCTCTCTGTTGCCCAGGCTGGAGTGCAGTGCTGCGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAA
GTGATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGACTACAGAACCACTACACCCAGATAATTTTTGTATTTTTAGTTGA
GATGGGGTTTTACCATGTTTAGTAGAGACCAGGCCAGGCTGGTCTCGAAATCCTGACCTCAGGTGATCTGCCCACCTCAG
CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACACCGGGCTGGTGTTGAGATTTTATCTAGACCTGGCAGCCCTC
TCCTTCACCAGTAACTCCTAAAACCAGGGACCCCTGGAGGGGAGGCCACCTCTCCTTCCCTGCCCCGCCCTGGTCCCAGG
CTTAGCCTCTCCCCCTGTTCACAGTGCCTCAACCTGGTGTTCCTGCTGGCAGACGTGTGGTTCGGCTTTCTGCCAAGCAT
CTACCTCGTCTTCCTGATCATTCTGTATGAGGGGCTCCTGGGAGGCGCAGCCTACGTGAACACCTTCCACAACATCGCCC
TGGAGGTCAGCATTGGCCGGGCAAGGGCTGGGGGTGGCCTGTCCAGGGACACCCAGGGCAGGGATGTCTGGGACTGAAGC
CTCACCCCTGCTCTCTGCCCTCCCAGACCAGTGATGAGCACCGGGAGTTTGCAATGGCGGCCACCTGCATCTCTGACACA
CTGGGGATCTCCCTGTCGGGGCTCCTGGCTTTGCCTCTGCATGACTTCCTCTGCCAGCTCTCCTGATACTCGGGATCCTC
AGGACGCAGGTCACATTCACCTGTGGGCAGAGGGACAGGTCAGACACCCAGGCCCACCCCAGAGACCCTCCATGAACTGT
GCTCCCAGCCTTCCCGGCAGGTCTGGGAGTAGGGAAGGGCTGAAGCCTTGTTTCCCTTGCAGGGGGGCCAGCCATTGTCT
CCCACTTGGGGAGTTTCTTCCTGGCATCATGCCTTCTGAATAAATGCCGATTTTATCCATGGAC
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Primary source |
RefSeq : NM_001042432.1 (GI:109698600)
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Name |
Ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 1
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
1915 nt
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Map |
16p12.1
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Location |
Chromosome 16 (NC_000016.9) strand : -
28488599...28488955 | 28489057...28489197 | 28493425...28493518 | 28493647...28493702 |
28493797...28493865 | 28493946...28493992 | 28495326...28495438 | 28497667...28497810 |
28497898...28497970 | 28498776...28498861 | 28498982...28499061 | 28499911...28499982 |
28500610...28500706 | 28502802...28502880 | 28503034...28503155 | 28503340...28503622 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1a
|
1
|
283
|
283
|
1
|
Exon 1c
|
284
|
405
|
122
|
1
|
Exon 2
|
406
|
484
|
79
|
1
|
Exon 3
|
485
|
581
|
97
|
1
|
Exon 4
|
582
|
653
|
72
|
1
|
Exon 5
|
654
|
733
|
80
|
1
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Exon 6
|
734
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819
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86
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1
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Exon 7
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820
|
892
|
73
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1
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Exon 8
|
893
|
1036
|
144
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1
|
Exon 9
|
1037
|
1149
|
113
|
1
|
Exon 10
|
1150
|
1196
|
47
|
1
|
Exon 11
|
1197
|
1265
|
69
|
1
|
Exon 12
|
1266
|
1321
|
56
|
1
|
Exon 13
|
1322
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1415
|
94
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1
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Exon 14
|
1416
|
1556
|
141
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1
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Exon 15
|
1557
|
1913
|
357
|
1
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Primary source |
NCBI : CCDS10632
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Nucleotide |
CLN3, mRNA isoform 1[NM_001042432.1] : 360...1676
|
Length |
1317
|
Location |
Chromosome 16 (NC_000016.9) strand : -
28488836...28488955 | 28489057...28489197 | 28493425...28493518 | 28493647...28493702 |
28493797...28493865 | 28493946...28493992 | 28495326...28495438 | 28497667...28497810 |
28497898...28497970 | 28498776...28498861 | 28498982...28499061 | 28499911...28499982 |
28500610...28500706 | 28502802...28502880 | 28503034...28503079 |
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Start codon |
1
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Translation |
NP_001035897.1 |
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1 |
ATAACTGGTG |
CTGGCAGGCT |
ACTGTCTCGG |
TCTTGGGCGC |
CACTGATCTA |
AGGTCACGGC |
TCTGCTTGCT |
GCTCCCACCC |
|
81 |
GCTCCAGTTT |
AAAACCTGCG |
GTTCCAGGGT |
TCTCCAGCCC |
CTCCCTTTTT |
CACGCTCCGA |
AGCCGAGAAG |
GCCCAAAGCG |
|
161 |
AAGACAGAGA |
GGACCCGGAA |
GTAGGGAAAA |
CCTCTGAGCA |
CGTGATGGGG |
GAACACGCGG |
GTGCTGTCAC |
GTGATCCGAC |
|
241 |
AAACGGCCTC |
TGCATAGTGC |
AGAACATTCT |
GCTGCTCTTA |
AAGACCCTCA |
TCCCTCCCGT |
GGGAGCCCCC |
TTTGGACACT |
|
321 |
CTATGACCCT |
GGACCCTCGG |
GGGACCTGAA |
CTTGATGCGA |
TGGGAGGCTG |
TGCAGGCTCG |
CGGCGGCGCT |
TTTCGGATTC |
|
401 |
CGAGGGGGAG |
GAGACCGTCC |
CGGAGCCCCG |
GCTCCCTCTG |
TTGGACCATC |
AGGGCGCGCA |
TTGGAAGAAC |
GCGGTGGGCT |
|
481 |
TCTGGCTGCT |
GGGCCTTTGC |
AACAACTTCT |
CTTATGTGGT |
GATGCTGAGT |
GCCGCCCACG |
ACATCCTTAG |
CCACAAGAGG |
|
561 |
ACATCGGGAA |
ACCAGAGCCA |
TGTGGACCCA |
GGCCCAACGC |
CGATCCCCCA |
CAACAGCTCA |
TCACGATTTG |
ACTGCAACTC |
|
641 |
TGTCTCTACG |
GCTGCTGTGC |
TCCTGGCGGA |
CATCCTCCCC |
ACACTCGTCA |
TCAAATTGTT |
GGCTCCTCTT |
GGCCTTCACC |
|
721 |
TGCTGCCCTA |
CAGCCCCCGG |
GTTCTCGTCA |
GTGGGATTTG |
TGCTGCTGGA |
AGCTTCGTCC |
TGGTTGCCTT |
TTCTCATTCT |
|
801 |
GTGGGGACCA |
GCCTGTGTGG |
TGTGGTCTTC |
GCTAGCATCT |
CATCAGGCCT |
TGGGGAGGTC |
ACCTTCCTCT |
CCCTCACTGC |
|
881 |
CTTCTACCCC |
AGGGCCGTGA |
TCTCCTGGTG |
GTCCTCAGGG |
ACTGGGGGAG |
CTGGGCTGCT |
GGGGGCCCTG |
TCCTACCTGG |
|
961 |
GCCTCACCCA |
GGCCGGCCTC |
TCCCCTCAGC |
AGACCCTGCT |
GTCCATGCTG |
GGTATCCCTG |
CCCTGCTGCT |
GGCCAGCTAT |
|
1041 |
TTCTTGTTGC |
TCACATCTCC |
TGAGGCCCAG |
GACCCTGGAG |
GGGAAGAAGA |
AGCAGAGAGC |
GCAGCCCGGC |
AGCCCCTCAT |
|
1121 |
AAGAACCGAG |
GCCCCGGAGT |
CGAAGCCAGG |
CTCCAGCTCC |
AGCCTCTCCC |
TTCGGGAAAG |
GTGGACAGTG |
TTCAAGGGTC |
|
1201 |
TGCTGTGGTA |
CATTGTTCCC |
TTGGTCGTAG |
TTTACTTTGC |
CGAGTATTTC |
ATTAACCAGG |
GACTTTTTGA |
ACTCCTCTTT |
|
1281 |
TTCTGGAACA |
CTTCCCTGAG |
TCACGCTCAG |
CAATACCGCT |
GGTACCAGAT |
GCTGTACCAG |
GCTGGCGTCT |
TTGCCTCCCG |
|
1361 |
CTCTTCTCTC |
CGCTGCTGTC |
GCATCCGTTT |
CACCTGGGCC |
CTGGCCCTGC |
TGCAGTGCCT |
CAACCTGGTG |
TTCCTGCTGG |
|
1441 |
CAGACGTGTG |
GTTCGGCTTT |
CTGCCAAGCA |
TCTACCTCGT |
CTTCCTGATC |
ATTCTGTATG |
AGGGGCTCCT |
GGGAGGCGCA |
|
1521 |
GCCTACGTGA |
ACACCTTCCA |
CAACATCGCC |
CTGGAGACCA |
GTGATGAGCA |
CCGGGAGTTT |
GCAATGGCGG |
CCACCTGCAT |
|
1601 |
CTCTGACACA |
CTGGGGATCT |
CCCTGTCGGG |
GCTCCTGGCT |
TTGCCTCTGC |
ATGACTTCCT |
CTGCCAGCTC |
TCCTGATACT |
|
1681 |
CGGGATCCTC |
AGGACGCAGG |
TCACATTCAC |
CTGTGGGCAG |
AGGGACAGGT |
CAGACACCCA |
GGCCCACCCC |
AGAGACCCTC |
|
1761 |
CATGAACTGT |
GCTCCCAGCC |
TTCCCGGCAG |
GTCTGGGAGT |
AGGGAAGGGC |
TGAAGCCTTG |
TTTCCCTTGC |
AGGGGGGCCA |
|
1841 |
GCCATTGTCT |
CCCACTTGGG |
GAGTTTCTTC |
CTGGCATCAT |
GCCTTCTGAA |
TAAATGCCGA |
TTTTATCCAT |
GGAAA |
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>gi|109698600|ref|NM_001042432.1|Ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 1
ATAACTGGTGCTGGCAGGCTACTGTCTCGGTCTTGGGCGCCACTGATCTAAGGTCACGGCTCTGCTTGCTGCTCCCACCC
GCTCCAGTTTAAAACCTGCGGTTCCAGGGTTCTCCAGCCCCTCCCTTTTTCACGCTCCGAAGCCGAGAAGGCCCAAAGCG
AAGACAGAGAGGACCCGGAAGTAGGGAAAACCTCTGAGCACGTGATGGGGGAACACGCGGGTGCTGTCACGTGATCCGAC
AAACGGCCTCTGCATAGTGCAGAACATTCTGCTGCTCTTAAAGACCCTCATCCCTCCCGTGGGAGCCCCCTTTGGACACT
CTATGACCCTGGACCCTCGGGGGACCTGAACTTGATGCGATGGGAGGCTGTGCAGGCTCGCGGCGGCGCTTTTCGGATTC
CGAGGGGGAGGAGACCGTCCCGGAGCCCCGGCTCCCTCTGTTGGACCATCAGGGCGCGCATTGGAAGAACGCGGTGGGCT
TCTGGCTGCTGGGCCTTTGCAACAACTTCTCTTATGTGGTGATGCTGAGTGCCGCCCACGACATCCTTAGCCACAAGAGG
ACATCGGGAAACCAGAGCCATGTGGACCCAGGCCCAACGCCGATCCCCCACAACAGCTCATCACGATTTGACTGCAACTC
TGTCTCTACGGCTGCTGTGCTCCTGGCGGACATCCTCCCCACACTCGTCATCAAATTGTTGGCTCCTCTTGGCCTTCACC
TGCTGCCCTACAGCCCCCGGGTTCTCGTCAGTGGGATTTGTGCTGCTGGAAGCTTCGTCCTGGTTGCCTTTTCTCATTCT
GTGGGGACCAGCCTGTGTGGTGTGGTCTTCGCTAGCATCTCATCAGGCCTTGGGGAGGTCACCTTCCTCTCCCTCACTGC
CTTCTACCCCAGGGCCGTGATCTCCTGGTGGTCCTCAGGGACTGGGGGAGCTGGGCTGCTGGGGGCCCTGTCCTACCTGG
GCCTCACCCAGGCCGGCCTCTCCCCTCAGCAGACCCTGCTGTCCATGCTGGGTATCCCTGCCCTGCTGCTGGCCAGCTAT
TTCTTGTTGCTCACATCTCCTGAGGCCCAGGACCCTGGAGGGGAAGAAGAAGCAGAGAGCGCAGCCCGGCAGCCCCTCAT
AAGAACCGAGGCCCCGGAGTCGAAGCCAGGCTCCAGCTCCAGCCTCTCCCTTCGGGAAAGGTGGACAGTGTTCAAGGGTC
TGCTGTGGTACATTGTTCCCTTGGTCGTAGTTTACTTTGCCGAGTATTTCATTAACCAGGGACTTTTTGAACTCCTCTTT
TTCTGGAACACTTCCCTGAGTCACGCTCAGCAATACCGCTGGTACCAGATGCTGTACCAGGCTGGCGTCTTTGCCTCCCG
CTCTTCTCTCCGCTGCTGTCGCATCCGTTTCACCTGGGCCCTGGCCCTGCTGCAGTGCCTCAACCTGGTGTTCCTGCTGG
CAGACGTGTGGTTCGGCTTTCTGCCAAGCATCTACCTCGTCTTCCTGATCATTCTGTATGAGGGGCTCCTGGGAGGCGCA
GCCTACGTGAACACCTTCCACAACATCGCCCTGGAGACCAGTGATGAGCACCGGGAGTTTGCAATGGCGGCCACCTGCAT
CTCTGACACACTGGGGATCTCCCTGTCGGGGCTCCTGGCTTTGCCTCTGCATGACTTCCTCTGCCAGCTCTCCTGATACT
CGGGATCCTCAGGACGCAGGTCACATTCACCTGTGGGCAGAGGGACAGGTCAGACACCCAGGCCCACCCCAGAGACCCTC
CATGAACTGTGCTCCCAGCCTTCCCGGCAGGTCTGGGAGTAGGGAAGGGCTGAAGCCTTGTTTCCCTTGCAGGGGGGCCA
GCCATTGTCTCCCACTTGGGGAGTTTCTTCCTGGCATCATGCCTTCTGAATAAATGCCGATTTTATCCATGGAAA
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Primary source |
RefSeq : NM_000086.2 (GI:109698602)
|
Name |
Ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 2
|
Type of transcript |
mRNA
|
Organism |
Homo sapiens
|
Length |
1879 nt
|
Map |
16p12.1
|
Location |
Chromosome 16 (NC_000016.9) strand : -
28488599...28488955 | 28489057...28489197 | 28493425...28493518 | 28493647...28493702 |
28493797...28493865 | 28493946...28493992 | 28495326...28495438 | 28497667...28497810 |
28497898...28497970 | 28498776...28498861 | 28498982...28499061 | 28499911...28499982 |
28500610...28500706 | 28502802...28502880 | 28503034...28503402 |
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|
Exon(s) |
Start |
End |
Length |
is coding |
Exon 1b
|
1
|
369
|
369
|
1
|
Exon 2
|
370
|
448
|
79
|
1
|
Exon 3
|
449
|
545
|
97
|
1
|
Exon 4
|
546
|
617
|
72
|
1
|
Exon 5
|
618
|
697
|
80
|
1
|
Exon 6
|
698
|
783
|
86
|
1
|
Exon 7
|
784
|
856
|
73
|
1
|
Exon 8
|
857
|
1000
|
144
|
1
|
Exon 9
|
1001
|
1113
|
113
|
1
|
Exon 10
|
1114
|
1160
|
47
|
1
|
Exon 11
|
1161
|
1229
|
69
|
1
|
Exon 12
|
1230
|
1285
|
56
|
1
|
Exon 13
|
1286
|
1379
|
94
|
1
|
Exon 14
|
1380
|
1520
|
141
|
1
|
Exon 15
|
1521
|
1877
|
357
|
1
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ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
rs28612835
|
SNP
|
148
|
a/g
|
1
|
?
|
dbSNP
|
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Primary source |
NCBI : CCDS10632
|
Nucleotide |
CLN3, mRNA isoform 2[NM_000086.2] : 324...1640
|
Length |
1317
|
Location |
Chromosome 16 (NC_000016.9) strand : -
28488836...28488955 | 28489057...28489197 | 28493425...28493518 | 28493647...28493702 |
28493797...28493865 | 28493946...28493992 | 28495326...28495438 | 28497667...28497810 |
28497898...28497970 | 28498776...28498861 | 28498982...28499061 | 28499911...28499982 |
28500610...28500706 | 28502802...28502880 | 28503034...28503079 |
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Start codon |
1
|
Translation |
NP_000077.1 |
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|
1 |
GTGCTGTCAC |
GTGATCCGAC |
AAACGGCCTC |
TGCATAGTGC |
AGAACATTCT |
GCTGCTCTTA |
AAGGTACAGG |
CCTCAGGGTC |
|
81 |
CCTGCTGTAG |
ACGGGGCGGG |
GGAGAGTACG |
ATGGGTGGGG |
CGTGGTGGGT |
CGTAGGGCGC |
TCGAGATGGA |
GCCCCCAGCT |
|
161 |
TCCTTGATGG |
ATCGCGGGGC |
GCGAGTGCCC |
TAGACAAGCC |
GGAGCTGGGA |
CCGGCAATCG |
GGCGTTGATC |
CTTGTCACCT |
|
241 |
GTCGCAGACC |
CTCATCCCTC |
CCGTGGGAGC |
CCCCTTTGGA |
CACTCTATGA |
CCCTGGACCC |
TCGGGGGACC |
TGAACTTGAT |
|
321 |
GCGATGGGAG |
GCTGTGCAGG |
CTCGCGGCGG |
CGCTTTTCGG |
ATTCCGAGGG |
GGAGGAGACC |
GTCCCGGAGC |
CCCGGCTCCC |
|
401 |
TCTGTTGGAC |
CATCAGGGCG |
CGCATTGGAA |
GAACGCGGTG |
GGCTTCTGGC |
TGCTGGGCCT |
TTGCAACAAC |
TTCTCTTATG |
|
481 |
TGGTGATGCT |
GAGTGCCGCC |
CACGACATCC |
TTAGCCACAA |
GAGGACATCG |
GGAAACCAGA |
GCCATGTGGA |
CCCAGGCCCA |
|
561 |
ACGCCGATCC |
CCCACAACAG |
CTCATCACGA |
TTTGACTGCA |
ACTCTGTCTC |
TACGGCTGCT |
GTGCTCCTGG |
CGGACATCCT |
|
641 |
CCCCACACTC |
GTCATCAAAT |
TGTTGGCTCC |
TCTTGGCCTT |
CACCTGCTGC |
CCTACAGCCC |
CCGGGTTCTC |
GTCAGTGGGA |
|
721 |
TTTGTGCTGC |
TGGAAGCTTC |
GTCCTGGTTG |
CCTTTTCTCA |
TTCTGTGGGG |
ACCAGCCTGT |
GTGGTGTGGT |
CTTCGCTAGC |
|
801 |
ATCTCATCAG |
GCCTTGGGGA |
GGTCACCTTC |
CTCTCCCTCA |
CTGCCTTCTA |
CCCCAGGGCC |
GTGATCTCCT |
GGTGGTCCTC |
|
881 |
AGGGACTGGG |
GGAGCTGGGC |
TGCTGGGGGC |
CCTGTCCTAC |
CTGGGCCTCA |
CCCAGGCCGG |
CCTCTCCCCT |
CAGCAGACCC |
|
961 |
TGCTGTCCAT |
GCTGGGTATC |
CCTGCCCTGC |
TGCTGGCCAG |
CTATTTCTTG |
TTGCTCACAT |
CTCCTGAGGC |
CCAGGACCCT |
|
1041 |
GGAGGGGAAG |
AAGAAGCAGA |
GAGCGCAGCC |
CGGCAGCCCC |
TCATAAGAAC |
CGAGGCCCCG |
GAGTCGAAGC |
CAGGCTCCAG |
|
1121 |
CTCCAGCCTC |
TCCCTTCGGG |
AAAGGTGGAC |
AGTGTTCAAG |
GGTCTGCTGT |
GGTACATTGT |
TCCCTTGGTC |
GTAGTTTACT |
|
1201 |
TTGCCGAGTA |
TTTCATTAAC |
CAGGGACTTT |
TTGAACTCCT |
CTTTTTCTGG |
AACACTTCCC |
TGAGTCACGC |
TCAGCAATAC |
|
1281 |
CGCTGGTACC |
AGATGCTGTA |
CCAGGCTGGC |
GTCTTTGCCT |
CCCGCTCTTC |
TCTCCGCTGC |
TGTCGCATCC |
GTTTCACCTG |
|
1361 |
GGCCCTGGCC |
CTGCTGCAGT |
GCCTCAACCT |
GGTGTTCCTG |
CTGGCAGACG |
TGTGGTTCGG |
CTTTCTGCCA |
AGCATCTACC |
|
1441 |
TCGTCTTCCT |
GATCATTCTG |
TATGAGGGGC |
TCCTGGGAGG |
CGCAGCCTAC |
GTGAACACCT |
TCCACAACAT |
CGCCCTGGAG |
|
1521 |
ACCAGTGATG |
AGCACCGGGA |
GTTTGCAATG |
GCGGCCACCT |
GCATCTCTGA |
CACACTGGGG |
ATCTCCCTGT |
CGGGGCTCCT |
|
1601 |
GGCTTTGCCT |
CTGCATGACT |
TCCTCTGCCA |
GCTCTCCTGA |
TACTCGGGAT |
CCTCAGGACG |
CAGGTCACAT |
TCACCTGTGG |
|
1681 |
GCAGAGGGAC |
AGGTCAGACA |
CCCAGGCCCA |
CCCCAGAGAC |
CCTCCATGAA |
CTGTGCTCCC |
AGCCTTCCCG |
GCAGGTCTGG |
|
1761 |
GAGTAGGGAA |
GGGCTGAAGC |
CTTGTTTCCC |
TTGCAGGGGG |
GCCAGCCATT |
GTCTCCCACT |
TGGGGAGTTT |
CTTCCTGGCA |
|
1841 |
TCATGCCTTC |
TGAATAAATG |
CCGATTTTAT |
CCATGGAAA |
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>gi|109698602|ref|NM_000086.2|Ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 2
GTGCTGTCACGTGATCCGACAAACGGCCTCTGCATAGTGCAGAACATTCTGCTGCTCTTAAAGGTACAGGCCTCAGGGTC
CCTGCTGTAGACGGGGCGGGGGAGAGTACGATGGGTGGGGCGTGGTGGGTCGTAGGGCGCTCGAGATGGAGCCCCCAGCT
TCCTTGATGGATCGCGGGGCGCGAGTGCCCTAGACAAGCCGGAGCTGGGACCGGCAATCGGGCGTTGATCCTTGTCACCT
GTCGCAGACCCTCATCCCTCCCGTGGGAGCCCCCTTTGGACACTCTATGACCCTGGACCCTCGGGGGACCTGAACTTGAT
GCGATGGGAGGCTGTGCAGGCTCGCGGCGGCGCTTTTCGGATTCCGAGGGGGAGGAGACCGTCCCGGAGCCCCGGCTCCC
TCTGTTGGACCATCAGGGCGCGCATTGGAAGAACGCGGTGGGCTTCTGGCTGCTGGGCCTTTGCAACAACTTCTCTTATG
TGGTGATGCTGAGTGCCGCCCACGACATCCTTAGCCACAAGAGGACATCGGGAAACCAGAGCCATGTGGACCCAGGCCCA
ACGCCGATCCCCCACAACAGCTCATCACGATTTGACTGCAACTCTGTCTCTACGGCTGCTGTGCTCCTGGCGGACATCCT
CCCCACACTCGTCATCAAATTGTTGGCTCCTCTTGGCCTTCACCTGCTGCCCTACAGCCCCCGGGTTCTCGTCAGTGGGA
TTTGTGCTGCTGGAAGCTTCGTCCTGGTTGCCTTTTCTCATTCTGTGGGGACCAGCCTGTGTGGTGTGGTCTTCGCTAGC
ATCTCATCAGGCCTTGGGGAGGTCACCTTCCTCTCCCTCACTGCCTTCTACCCCAGGGCCGTGATCTCCTGGTGGTCCTC
AGGGACTGGGGGAGCTGGGCTGCTGGGGGCCCTGTCCTACCTGGGCCTCACCCAGGCCGGCCTCTCCCCTCAGCAGACCC
TGCTGTCCATGCTGGGTATCCCTGCCCTGCTGCTGGCCAGCTATTTCTTGTTGCTCACATCTCCTGAGGCCCAGGACCCT
GGAGGGGAAGAAGAAGCAGAGAGCGCAGCCCGGCAGCCCCTCATAAGAACCGAGGCCCCGGAGTCGAAGCCAGGCTCCAG
CTCCAGCCTCTCCCTTCGGGAAAGGTGGACAGTGTTCAAGGGTCTGCTGTGGTACATTGTTCCCTTGGTCGTAGTTTACT
TTGCCGAGTATTTCATTAACCAGGGACTTTTTGAACTCCTCTTTTTCTGGAACACTTCCCTGAGTCACGCTCAGCAATAC
CGCTGGTACCAGATGCTGTACCAGGCTGGCGTCTTTGCCTCCCGCTCTTCTCTCCGCTGCTGTCGCATCCGTTTCACCTG
GGCCCTGGCCCTGCTGCAGTGCCTCAACCTGGTGTTCCTGCTGGCAGACGTGTGGTTCGGCTTTCTGCCAAGCATCTACC
TCGTCTTCCTGATCATTCTGTATGAGGGGCTCCTGGGAGGCGCAGCCTACGTGAACACCTTCCACAACATCGCCCTGGAG
ACCAGTGATGAGCACCGGGAGTTTGCAATGGCGGCCACCTGCATCTCTGACACACTGGGGATCTCCCTGTCGGGGCTCCT
GGCTTTGCCTCTGCATGACTTCCTCTGCCAGCTCTCCTGATACTCGGGATCCTCAGGACGCAGGTCACATTCACCTGTGG
GCAGAGGGACAGGTCAGACACCCAGGCCCACCCCAGAGACCCTCCATGAACTGTGCTCCCAGCCTTCCCGGCAGGTCTGG
GAGTAGGGAAGGGCTGAAGCCTTGTTTCCCTTGCAGGGGGGCCAGCCATTGTCTCCCACTTGGGGAGTTTCTTCCTGGCA
TCATGCCTTCTGAATAAATGCCGATTTTATCCATGGAAA
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Exon number |
1a
|
Length |
283 nt
|
Location |
Chromosome 16 (NC_000016.9) : 28503340...28503622 (-)
|
Is part of |
CLN3, mRNA isoform 1
(NM_001042432.1)
|
Sequence |
Show
|
|
ATAACTGGTGCTGGCAGGCTACTGTCTCGGTCTTGGGCGCCACTGATCTAAGGTCACGGCTCTGCTTGCTGCTCCCACCC
GCTCCAGTTTAAAACCTGCGGTTCCAGGGTTCTCCAGCCCCTCCCTTTTTCACGCTCCGAAGCCGAGAAGGCCCAAAGCG
AAGACAGAGAGGACCCGGAAGTAGGGAAAACCTCTGAGCACGTGATGGGGGAACACGCGGGTGCTGTCACGTGATCCGAC
AAACGGCCTCTGCATAGTGCAGAACATTCTGCTGCTCTTAAAG
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Exon number |
1b
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Length |
369 nt
|
Location |
Chromosome 16 (NC_000016.9) : 28503034...28503402 (-)
|
Is part of |
CLN3, mRNA isoform 2
(NM_000086.2)
|
Sequence |
Show
|
|
GTGCTGTCACGTGATCCGACAAACGGCCTCTGCATAGTGCAGAACATTCTGCTGCTCTTAAAGGTACAGGCCTCAGGGTC
CCTGCTGTAGACGGGGCGGGGGAGAGTACGATGGGTGGGGCGTGGTGGGTCGTAGGGCGCTCGAGATGGAGCCCCCAGCT
TCCTTGATGGATCGCGGGGCGCGAGTGCCCTAGACAAGCCGGAGCTGGGACCGGCAATCGGGCGTTGATCCTTGTCACCT
GTCGCAGACCCTCATCCCTCCCGTGGGAGCCCCCTTTGGACACTCTATGACCCTGGACCCTCGGGGGACCTGAACTTGAT
GCGATGGGAGGCTGTGCAGGCTCGCGGCGGCGCTTTTCGGATTCCGAGG
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Exon number |
1c
|
Length |
122 nt
|
Location |
Chromosome 16 (NC_000016.9) : 28503034...28503155 (-)
|
Is part of |
CLN3, mRNA isoform 1
(NM_001042432.1)
|
Sequence |
Show
|
|
ACCCTCATCCCTCCCGTGGGAGCCCCCTTTGGACACTCTATGACCCTGGACCCTCGGGGGACCTGAACTTGATGCGATGG
GAGGCTGTGCAGGCTCGCGGCGGCGCTTTTCGGATTCCGAGG
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Exon number |
15
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Length |
357 nt
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Location |
Chromosome 16 (NC_000016.9) : 28488599...28488955 (-)
|
Is part of |
CLN3, mRNA isoform 1
(NM_001042432.1)
CLN3, mRNA isoform 2
(NM_000086.2)
|
Sequence |
Show
|
|
ACCAGTGATGAGCACCGGGAGTTTGCAATGGCGGCCACCTGCATCTCTGACACACTGGGGATCTCCCTGTCGGGGCTCCT
GGCTTTGCCTCTGCATGACTTCCTCTGCCAGCTCTCCTGATACTCGGGATCCTCAGGACGCAGGTCACATTCACCTGTGG
GCAGAGGGACAGGTCAGACACCCAGGCCCACCCCAGAGACCCTCCATGAACTGTGCTCCCAGCCTTCCCGGCAGGTCTGG
GAGTAGGGAAGGGCTGAAGCCTTGTTTCCCTTGCAGGGGGGCCAGCCATTGTCTCCCACTTGGGGAGTTTCTTCCTGGCA
TCATGCCTTCTGAATAAATGCCGATTTTATCCATGGA
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|
Primary source |
Uniprot : Q13286
|
Name |
Battenin
|
Alternative name(s) |
Batten disease protein Protein CLN3
|
Synonym(s) |
|
Organism |
Homo sapiens
|
Length |
438 aa
|
Protein existence |
---
|
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General annotation (Comments)
|
top
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Disease
|
Defects in CLN3 are the cause of neuronal ceroid lipofuscinosis type 3 (CLN3) [MIM:204200]; also known as Batten disease. A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The hallmark of CLN3 is the ultrastructural pattern of lipopigment with a fingerprint profile, which can have 3 different appearances: pure within a lysosomal residual body; in conjunction with curvilinear or rectilinear profiles; and as a small component within large membrane-bound lysosomal vacuoles. The combination of fingerprint profiles within lysosomal vacuoles is a regular feature of blood lymphocytes from patients with CLN3.
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Ptm
|
Highly glycosylated.
|
Similarity
|
Belongs to the battenin family.
|
Subcellular location
|
Lysosome membrane; Multi-pass membrane protein.
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Biological process
|
autophagic vacuole fusion [GO:0000046]
regulation of action potential [GO:0001508]
globoside metabolic process [GO:0001575]
protein folding [GO:0006457]
cellular amino acid metabolic process [GO:0006520]
glucosylceramide metabolic process [GO:0006678]
galactosylceramide metabolic process [GO:0006681]
sphingomyelin metabolic process [GO:0006684]
receptor-mediated endocytosis [GO:0006898]
lysosomal lumen acidification [GO:0007042]
cell death [GO:0008219]
associative learning [GO:0008306]
arginine transport [GO:0015809]
negative regulation of macroautophagy [GO:0016242]
protein processing [GO:0016485]
protein catabolic process [GO:0030163]
ionotropic glutamate receptor signaling pathway [GO:0035235]
neurotransmitter metabolic process [GO:0042133]
amyloid precursor protein catabolic process [GO:0042987]
negative regulation of catalytic activity [GO:0043086]
negative regulation of neuron apoptosis [GO:0043524]
negative regulation of proteolysis [GO:0045861]
neuromuscular process controlling balance [GO:0050885]
cytosolic calcium ion homeostasis [GO:0051480]
|
Cellular component
|
Golgi membrane [GO:0000139]
membrane fraction [GO:0005624]
nucleus [GO:0005634]
mitochondrion [GO:0005739]
lysosomal membrane [GO:0005765]
early endosome [GO:0005769]
late endosome [GO:0005770]
autophagic vacuole [GO:0005776]
Golgi stack [GO:0005795]
trans-Golgi network [GO:0005802]
caveola [GO:0005901]
synaptic vesicle [GO:0008021]
integral to endoplasmic reticulum membrane [GO:0030176]
neuron projection [GO:0043005]
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Molecular function
|
unfolded protein binding [GO:0051082]
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With
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Uniprot accession
|
IntAct
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Alternative product(s)
|
top
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  |
Uniprot Identifier
|
Difference(s) with the 'canonical' sequence
|
Notes
|
Sequences
|
Isoform 1
|
Q13286-1
|
---
|
'Canonical' sequence
|
Get Fasta
|
Isoform 2
|
Q13286-2
|
178-225 : Missing
|
---
|
Get Fasta
|
Isoform 3
|
Q13286-3
|
280-302 : GLLWYIVPLVVVYFAEYFINQGL -> VRMMAG
|
---
|
Get Fasta
|
Isoform 4
|
Q13286-4
|
322-438 : Missing
|
---
|
Get Fasta
|
Isoform 5
|
Q13286-5
|
155-264 : Missing
353-438 : CLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTF HNIALETSDEHREFAMAATCISDTLGISLSGLLALPLHDFL CQLS -> MESRSVAQAGM
|
---
|
Get Fasta
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Feature key |
Position
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Length
|
Description
|
Feature identifier
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Region |
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|
|
Transmembrane
|
38 - 58
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-38
|
Transmembrane
|
99 - 119
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-99
|
Transmembrane
|
128 - 148
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-128
|
Transmembrane
|
180 - 200
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-180
|
Transmembrane
|
212 - 232
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-212
|
Transmembrane
|
278 - 298
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-278
|
Transmembrane
|
358 - 378
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-358
|
Transmembrane
|
407 - 427
|
21
|
Helical; (Potential)
|
Q13286-TRANSMEM-407
|
Natural variations |
|
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|
Natural variant site
|
101 - 101
|
1
|
L -> P (in CLN3)
|
VAR_005131
|
Natural variant site
|
170 - 170
|
1
|
L -> P (in CLN3)
|
VAR_005132
|
Natural variant site
|
295 - 295
|
1
|
E -> K (in CLN3)
|
VAR_005133
|
Natural variant site
|
330 - 330
|
1
|
V -> F (in CLN3)
|
VAR_005134
|
Natural variant site
|
334 - 334
|
1
|
R -> H (in CLN3)
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VAR_005136
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Natural variant site
|
334 - 334
|
1
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R -> C (in CLN3)
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VAR_005135
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Alternative sequence
|
155 - 264
|
110
|
Missing
|
VSP_004169
|
Alternative sequence
|
178 - 225
|
48
|
Missing
|
VSP_004166
|
Alternative sequence
|
280 - 302
|
23
|
GLLWYIVPLVVVYFAEYFINQGL -> VRMMAG
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VSP_004167
|
Alternative sequence
|
322 - 438
|
117
|
Missing
|
VSP_004168
|
Alternative sequence
|
353 - 438
|
86
|
CLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTF HNIALETSDEHREFAMAATCISDTLGISLSGLLALPLHDFL CQLS -> MESRSVAQAGM
|
VSP_004170
|
Amino acid modifications |
|
|
|
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Glycosylation
|
71 - 71
|
1
|
N-linked (GlcNAc...) (Potential)
|
Q13286-CARBOHYD-71
|
Glycosylation
|
85 - 85
|
1
|
N-linked (GlcNAc...) (Potential)
|
Q13286-CARBOHYD-85
|
Glycosylation
|
310 - 310
|
1
|
N-linked (GlcNAc...) (Potential)
|
Q13286-CARBOHYD-310
|
Modified residue
|
12 - 12
|
1
|
Phosphoserine
|
Q13286-MOD_RES-12
|
Modified residue
|
14 - 14
|
1
|
Phosphoserine
|
Q13286-MOD_RES-14
|
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1 |
MGGCAGSRRR |
FSDSEGEETV |
PEPRLPLLDH |
QGAHWKNAVG |
FWLLGLCNNF |
SYVVMLSAAH |
DILSHKRTSG |
NQSHVDPGPT |
|
81 |
PIPHNSSSRF |
DCNSVSTAAV |
LLADILPTLV |
IKLLAPLGLH |
LLPYSPRVLV |
SGICAAGSFV |
LVAFSHSVGT |
SLCGVVFASI |
|
161 |
SSGLGEVTFL |
SLTAFYPRAV |
ISWWSSGTGG |
AGLLGALSYL |
GLTQAGLSPQ |
QTLLSMLGIP |
ALLLASYFLL |
LTSPEAQDPG |
|
241 |
GEEEAESAAR |
QPLIRTEAPE |
SKPGSSSSLS |
LRERWTVFKG |
LLWYIVPLVV |
VYFAEYFINQ |
GLFELLFFWN |
TSLSHAQQYR |
|
321 |
WYQMLYQAGV |
FASRSSLRCC |
RIRFTWALAL |
LQCLNLVFLL |
ADVWFGFLPS |
IYLVFLIILY |
EGLLGGAAYV |
NTFHNIALET |
|
401 |
SDEHREFAMA |
ATCISDTLGI |
SLSGLLALPL |
HDFLCQLS |
|
|
|
|
|
|
|
|
|
|
|
|
>sp|Q13286|CLN3_human Battenin
MGGCAGSRRRFSDSEGEETVPEPRLPLLDHQGAHWKNAVGFWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPT
PIPHNSSSRFDCNSVSTAAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGICAAGSFVLVAFSHSVGTSLCGVVFASI
SSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQAGLSPQQTLLSMLGIPALLLASYFLLLTSPEAQDPG
GEEEAESAARQPLIRTEAPESKPGSSSSLSLRERWTVFKGLLWYIVPLVVVYFAEYFINQGLFELLFFWNTSLSHAQQYR
WYQMLYQAGVFASRSSLRCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTFHNIALET
SDEHREFAMAATCISDTLGISLSGLLALPLHDFLCQLS
|
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| |
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|
|
Primary source |
Uniprot : Q549S9
|
Name |
CLN3 protein [submitted name]
|
Alternative name(s) |
Ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease), isoform CRA_a [submitted name]
|
Synonym(s) |
|
Organism |
Homo sapiens
|
Length |
438 aa
|
Protein existence |
---
|
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General annotation (Comments)
|
top
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Cellular component
|
membrane [GO:0016020]
|
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With
|
Uniprot accession
|
IntAct
|
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Alternative product(s)
|
top
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Feature key |
Position
|
Length
|
Description
|
Feature identifier
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
MGGCAGSRRR |
FSDSEGEETV |
PEPRLPLLDH |
QGAHWKNAVG |
FWLLGLCNNF |
SYVVMLSAAH |
DILSHKRTSG |
NQSHVDPGPT |
|
81 |
PIPHNSSSRF |
DCNSVSTAAV |
LLADILPTLV |
IKLLAPLGLH |
LLPYSPRVLV |
SGICAAGSFV |
LVAFSHSVGT |
SLCGVVFASI |
|
161 |
SSGLGEVTFL |
SLTAFYPRAV |
ISWWSSGTGG |
AGLLGALSYL |
GLTQAGLSPQ |
QTLLSMLGIP |
ALLLASYFLL |
LTSPEAQDPG |
|
241 |
GEEEAESAAR |
QPLIRTEAPE |
SKPGSSSSLS |
LRERWTVFKG |
LLWYIVPLVV |
VYFAEYFINQ |
GLFELLFFWN |
TSLSHAQQYR |
|
321 |
WYQMLYQAGV |
FASRSSLRCC |
RIRFTWALAL |
LQCLNLVFLL |
ADVWFGFLPS |
IYLVFLIILY |
EGLLGGAAYV |
NTFHNIALET |
|
401 |
SDEHREFAMA |
ATCISDTLGI |
SLSGLLALPL |
HDFLCQLS |
|
|
|
|
|
|
|
|
|
|
|
|
>sp|Q549S9|Q549S9_human CLN3 protein [submitted name]
MGGCAGSRRRFSDSEGEETVPEPRLPLLDHQGAHWKNAVGFWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPT
PIPHNSSSRFDCNSVSTAAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGICAAGSFVLVAFSHSVGTSLCGVVFASI
SSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQAGLSPQQTLLSMLGIPALLLASYFLLLTSPEAQDPG
GEEEAESAARQPLIRTEAPESKPGSSSSLSLRERWTVFKGLLWYIVPLVVVYFAEYFINQGLFELLFFWNTSLSHAQQYR
WYQMLYQAGVFASRSSLRCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTFHNIALET
SDEHREFAMAATCISDTLGISLSGLLALPLHDFLCQLS
|
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