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(TMEM74) transmembrane protein 74 [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	5140
Official symbol	TMEM74
Official name	transmembrane protein 74
Gene type	gene with protein product
Organism	Homo sapiens
Location	Chromosome 8 (NC_000008.10) : 109795345...109799769 (-)
Map	8q23.1
Length	4425 nt

Alternative name(s) and Synynom(s)

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Synonyms	NET36; FLJ30668

External Links

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Ensembl	ENSG00000164841
Entrez	157753
HGNC	26409
HPRD	08702

Comment

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Bibliography

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Related Articles in PubMed

Genomic Context

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Go to ensembl

Sequence

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	FASTA

1	TTCTCCGGGA	ACCGTGCCGG	GAGAGCGCGC	GGTGCTGGAG	CCGCACCGGG	TGGCCGAAGC	AGAAGGTGAG	TGGCGGGGAG
81	TGGGATGGGG	TGGAGGCTTT	GAATGCAAGG	GTGAGAGCCC	TGGAGCCTAG	CAGAGCTGGA	GCGCATATCC	CCGCTCTCTC
161	TCCTTCGTCT	CCGAGTACTA	GGCGGACACA	TCCGTACCTC	GAATGCCTCA	GTGGGCGCAG	AGTTCACCAG	AAATGGATAG
241	CCGGATTCCT	CGGCGCCTGC	TGGGGGCACC	GCTGCCAGGT	GCTTGGGGCT	CGCTCTCCCG	GCTTTGCTCG	CACAGGGCGC
321	ATCCAGAGGT	CGCCTCCCCG	AGATCAGCCT	TGCCTGTGTC	AGTTTAAAGC	AAATATTAAT	GCTTTTAATT	GATGACAGAT
401	GGACGAGGGA	AAGTGCGTGT	CCCCTCGCTT	TAAGGTGCAA	TGTCGTTAAC	TGGGCTTTTA	AGCAGATCAG	AGGAAAAAGA
481	GGGAGAGGAC	GGAAGAAAAG	AGTCTTTAGC	TGGTCCCCTG	GGATTATCCA	TTCTCCACTG	AGAATGGAAA	CCCCGGATTA
561	GGGAGCTGCA	AAGGAAATCG	ACTGTGCTGC	TAGCATACCT	CCGGTAGAAC	AAGCGAACAA	GCGGGAGTAG	CTTTTCTTTA
641	AAGAGAGGTA	GAGGCGGCCG	TAGGGAATTA	AGTGGGGATT	TCTCTCTTCT	TTTGTTATAA	ACTGAAAGTC	TCAAAGAACC
721	CTGCTGATTT	TATCCAAGGT	AGGCTAGTGT	GATGAGTTAA	TGGTACCAAA	GGTTAATCAG	AGCCCCTAAT	GCCTGAGAAA
801	ACTGGAAGAA	GAGTTATCGG	TAATTGATGA	AGCCTGTTAC	CATCACTTCA	TTCATTGAGG	GATCCTTTAG	TGGGGGTTTG
881	TTCTAGTTTA	GTAGTGATTC	TTTTGCCCTG	TTGTTTTTTG	CTGTTTTCAC	TGTAGAGAAA	CTCCGATAAC	AGGAGAAAAA
961	CGTTTTCTGT	TTTGCTTTTT	TTGTTTTGTT	TTAAACAAAC	TCTTAGGTGT	AGCAGAAAAC	ATGTCAATTC	CCTCTCCCAT
1041	ATTTTGAGTT	GCCAGGTTGA	CCTTAGGTGA	CCCTTGCCTG	TGTTTCTGTT	ACCAGCTTTG	GAGCTGTGGA	TTTTGAATTA
1121	TAAGAAGCCT	CAAGCCGTTG	GGTTAAATCA	ATTATCACCC	TGGATTTGGA	AGCAAAATAA	AAGGAGCCTT	TGGTTAAAAT
1201	CTCTAATGAT	AGTGGAAAGT	GAATTTTTAT	TCCTTAGAAA	CATGGCAGAG	GCAGAGAAAA	GCCGATGGTT	TTCTGCTCAA
1281	ACCAAAGTTC	TCTCCCAGAA	ATGCCCCTTG	CTGCAGTCGG	GGGTGAGGAG	TGACATGTTT	ATAAAATTAC	AGAGGTAACC
1361	TTGGAAATAG	CTTCTCACCT	ATTTGTCTCC	ACAGAACTCT	TACTCTGTGG	GTTTATAGTT	TGTCTTTTAT	TATCAGTTCA
1441	CTTCTAGATT	GGGTTTGTAA	AACTATCCAG	ATGGTCAATT	TCTTGTGCAT	TGTGTGATAG	CAAAGCATGC	AGAGAGGGAG
1521	GAACACAGAC	CCAGGGAACG	GGAGTAGCAG	ATCCTGCAGC	TGGAGCAGGC	AGGTGTGTGT	GTGGAGGAGT	GGGTTGGCCC
1601	ATTGTATTTT	GCAGGGATTG	CCGTAAGGTC	TGTTGCCTGT	ATGCTTTGGG	GTCCAGAACA	TGCTTCCCCC	ATGGAGCAGT
1681	GAGGGAATAG	GGCTAAGTGG	AAGCACAGTG	AATAAGCAGC	ATATGGTCTT	GTAAATACAG	GGCTGTGTCA	CTAGGGTCAT
1761	TGGATGTATG	AGGTGTAAGC	TTAGCAGAGG	TGGCTGATTA	AGCTGGCCTT	TTTCATCTAC	TTCAGAGCTA	TGGAATCAAA
1841	ATGCTGAGTT	CCTGCCCAGC	TGATAGGGGT	GTATAGTCAT	TCACTGATGG	TGATGCTCCA	AAGCTAATCT	GTATTAGAAT
1921	TTGCTCTGAA	CTAGGGAGAG	TGTAAACACT	TACAATCTTA	CTGAATTAAC	AAGTCTATGC	TTCCCCAAGT	CCTCCAGAAA
2001	ATCGGCAGCT	CTGCTAAAAA	GGGCTCTTGC	CTTTCTCATT	TGTCTTTTTA	CAGGAAACTT	GCCTTCTCGT	TTGAGGGATC
2081	CTTTTGCAGG	AATGCGCGAG	TCCTTGAATA	AATTTGGCTT	GGTGACGGCA	GTATTCTTTC	TCAGTAGACA	CTGCCACTTC
2161	CTCCACGCAC	CTTTCTACCC	TGACTTAAGT	TTCTCAGTGT	TAATCACTAT	GACAAGTGAG	AGCATTTGTC	CCTTCCACAC
2241	TTTCCTGCCA	CTAGGTATCC	CCTCCCTTCT	TTTGCCTGTT	TGAGGTGGAA	AAGGGGCTAA	ACAGGTGCAG	CTGTGAAGGA
2321	AATGGGGACC	CCAGGAGCAA	CACTCCTGGA	AGTACAACCT	TAGCTTCTGT	TGGGTTCTTA	TCTAACTCTG	TTGCTATTGG
2401	CAGACTTTCC	GGAAGCTGCT	GGGGGATGTC	TGACTAGCTC	TCATGGAGCT	CCACTACCTT	GCTAAGAAGA	GCAACCAGGC
2481	AGACCTCTGT	GATGCCAGGG	ACTGGAGTTC	AAGAGGGCTG	CCTGGTGACC	AGGCAGATAC	AGCAGCCACA	AGAGCTGCTC
2561	TCTGCTGTCA	GAAACAGTGT	GCATCCACCC	CAAGAGCAAC	CGAGATGGAA	GGGTCTAAAC	TTAGTTCTTC	TCCAGCATCC
2641	CCCTCCTCCT	CTCTGCAAAA	CAGTACTCTT	CAGCCAGATG	CCTTTCCACC	AGGACTTCTC	CACTCAGGGA	ACAACCAAAT
2721	AACAGCGGAA	CGGAAAGTCT	GTAACTGCTG	CAGCCAGGAA	TTAGAAACTT	CTTTTACCTA	TGTGGACAAA	AACATCAACT
2801	TGGAGCAGCG	GAACCGGAGC	TCGCCATCAG	CAAAAGGGCA	TAATCACCCT	GGGGAGCTTG	GCTGGGAAAA	TCCAAATGAG
2881	TGGTCCCAAG	AGGCTGCCAT	ATCTTTGATA	TCTGAAGAGG	AGGATGATAC	AAGTTCAGAA	GCCACGTCTT	CAGGGAAGTC
2961	TATAGACTAT	GGTTTCATCA	GCGCCATCTT	GTTCTTGGTC	ACTGGGATCC	TGCTCGTGAT	CATCTCTTAC	ATCGTCCCAC
3041	GGGAAGTGAC	TGTGGACCCC	AACACTGTGG	CAGCCCGGGA	GATGGAGCGC	CTGGAGAAGG	AGAGTGCGAG	GCTGGGGGCT
3121	CACCTGGACC	GCTGTGTGAT	TGCGGGGCTC	TGCCTCCTCA	CGCTGGGGGG	CGTCATCCTG	TCCTGCTTGT	TAATGATGTC
3201	CATGTGGAAG	GGGGAGCTCT	ATCGTCGAAA	CAGATTTGCC	TCTTCCAAAG	AGTCTGCAAA	ACTCTATGGT	TCTTTCAACT
3281	TCAGGATGAA	AACCAGCACG	AATGAAAACA	CTCTGGAACT	GTCCTTGGTA	GAGGAAGATG	CGCTTGCTGT	ACAGAGTTAA
3361	TTCTGGTTGT	GAATATCTTG	AGAGTCTGCC	TTGGCATTTT	ATAATATGAA	AAAAGTTAAT	TTATAAAAAT	TCACAGTGCA
3441	ATTTATTTGC	CTGGCAAGAA	AAGTTTATTT	CACAAACCAA	CAGCCAGTAA	GTGTTTTTGT	TCTCTATGTG	TCTTCTATTT
3521	AGAAGAAAAG	CCATGTAAGA	TGTATAAGAA	ACCACAACCA	GCCACACCTA	TCCTTCTGAA	GAGCTGAAGG	CTAATTAATC
3601	TGTAATGGCC	AAGAACTTCT	ACTTCGATAG	AAAAATATTT	CTAATGACCC	AGTCTACAAA	TTATTTCTTT	TACACAAATA
3681	TATGATGTTA	TTCTTTGGAC	ACTAGGTGGT	CCTACACACA	GTAGGATCAA	TTGCTAATCT	ACTTTGTGAA	AAAGAACTAA
3761	GCACTAATCA	ATAATAAGGC	TTACATCTAA	TTCTCAAAGG	TGCTTATCCA	TTTTCTTGCT	AAATTATCCT	TCTTGTAATT
3841	TGGCTAAACA	CTAAAACATG	GAATTTTTAG	TTTGAATATT	TTGAAGTTTG	AGGATGTTGG	GCTTTCCTTA	TTGTAAAAAA
3921	TGTTATGTTT	GAAATTATTC	CTGTTTTCAA	AAATGGTAAT	TAAGTCATTA	GGATAAACTT	TCTAATAAAA	AAAAATTATG
4001	TAAATCATTG	TAAGACCAAT	GTGAATTTAA	ACCACAGTGT	TGGTGCCAGA	TATTAGCCAG	GGTCACAGGC	TCTTTTTTAA
4081	AATGAAGTCA	AATTAGTTAC	TGATATAAGT	TTTATATTTT	GTGATTTTGC	CATCATACTG	GTTATCTGTG	CTCTTGAAGT
4161	CTGCTGGTTC	TCACACCAGC	AGCAAGAGGC	AAGGCATGAG	ACATTTTAAA	TATATTTCCA	GACATCTAAA	CATCTAGACA
4241	GGCCTGAGTC	ATGATTGGCT	CTGGTGTGCT	TCCAGGTAAC	ATCTTGTTAT	TGCTGTTTGG	GGAAAACCAC	CAATAGAATT
4321	GCAGCTAGAC	TTTTGGGGAC	TGTGCCTCGC	AGGCTGTATC	ACTTGCTGTA	GGCCAAGCAA	CGAGCACTTC	CCTCATGGTA
4401	GCAACAGTCC	TTAAGCCCAA	AGCCA

	>ref\|Gene_ID:157753\|TMEM74\|NC_000008.10:109795345...109799769 (-) TTCTCCGGGAACCGTGCCGGGAGAGCGCGCGGTGCTGGAGCCGCACCGGGTGGCCGAAGCAGAAGGTGAGTGGCGGGGAG TGGGATGGGGTGGAGGCTTTGAATGCAAGGGTGAGAGCCCTGGAGCCTAGCAGAGCTGGAGCGCATATCCCCGCTCTCTC TCCTTCGTCTCCGAGTACTAGGCGGACACATCCGTACCTCGAATGCCTCAGTGGGCGCAGAGTTCACCAGAAATGGATAG CCGGATTCCTCGGCGCCTGCTGGGGGCACCGCTGCCAGGTGCTTGGGGCTCGCTCTCCCGGCTTTGCTCGCACAGGGCGC ATCCAGAGGTCGCCTCCCCGAGATCAGCCTTGCCTGTGTCAGTTTAAAGCAAATATTAATGCTTTTAATTGATGACAGAT GGACGAGGGAAAGTGCGTGTCCCCTCGCTTTAAGGTGCAATGTCGTTAACTGGGCTTTTAAGCAGATCAGAGGAAAAAGA GGGAGAGGACGGAAGAAAAGAGTCTTTAGCTGGTCCCCTGGGATTATCCATTCTCCACTGAGAATGGAAACCCCGGATTA GGGAGCTGCAAAGGAAATCGACTGTGCTGCTAGCATACCTCCGGTAGAACAAGCGAACAAGCGGGAGTAGCTTTTCTTTA AAGAGAGGTAGAGGCGGCCGTAGGGAATTAAGTGGGGATTTCTCTCTTCTTTTGTTATAAACTGAAAGTCTCAAAGAACC CTGCTGATTTTATCCAAGGTAGGCTAGTGTGATGAGTTAATGGTACCAAAGGTTAATCAGAGCCCCTAATGCCTGAGAAA ACTGGAAGAAGAGTTATCGGTAATTGATGAAGCCTGTTACCATCACTTCATTCATTGAGGGATCCTTTAGTGGGGGTTTG TTCTAGTTTAGTAGTGATTCTTTTGCCCTGTTGTTTTTTGCTGTTTTCACTGTAGAGAAACTCCGATAACAGGAGAAAAA CGTTTTCTGTTTTGCTTTTTTTGTTTTGTTTTAAACAAACTCTTAGGTGTAGCAGAAAACATGTCAATTCCCTCTCCCAT ATTTTGAGTTGCCAGGTTGACCTTAGGTGACCCTTGCCTGTGTTTCTGTTACCAGCTTTGGAGCTGTGGATTTTGAATTA TAAGAAGCCTCAAGCCGTTGGGTTAAATCAATTATCACCCTGGATTTGGAAGCAAAATAAAAGGAGCCTTTGGTTAAAAT CTCTAATGATAGTGGAAAGTGAATTTTTATTCCTTAGAAACATGGCAGAGGCAGAGAAAAGCCGATGGTTTTCTGCTCAA ACCAAAGTTCTCTCCCAGAAATGCCCCTTGCTGCAGTCGGGGGTGAGGAGTGACATGTTTATAAAATTACAGAGGTAACC TTGGAAATAGCTTCTCACCTATTTGTCTCCACAGAACTCTTACTCTGTGGGTTTATAGTTTGTCTTTTATTATCAGTTCA CTTCTAGATTGGGTTTGTAAAACTATCCAGATGGTCAATTTCTTGTGCATTGTGTGATAGCAAAGCATGCAGAGAGGGAG GAACACAGACCCAGGGAACGGGAGTAGCAGATCCTGCAGCTGGAGCAGGCAGGTGTGTGTGTGGAGGAGTGGGTTGGCCC ATTGTATTTTGCAGGGATTGCCGTAAGGTCTGTTGCCTGTATGCTTTGGGGTCCAGAACATGCTTCCCCCATGGAGCAGT GAGGGAATAGGGCTAAGTGGAAGCACAGTGAATAAGCAGCATATGGTCTTGTAAATACAGGGCTGTGTCACTAGGGTCAT TGGATGTATGAGGTGTAAGCTTAGCAGAGGTGGCTGATTAAGCTGGCCTTTTTCATCTACTTCAGAGCTATGGAATCAAA ATGCTGAGTTCCTGCCCAGCTGATAGGGGTGTATAGTCATTCACTGATGGTGATGCTCCAAAGCTAATCTGTATTAGAAT TTGCTCTGAACTAGGGAGAGTGTAAACACTTACAATCTTACTGAATTAACAAGTCTATGCTTCCCCAAGTCCTCCAGAAA ATCGGCAGCTCTGCTAAAAAGGGCTCTTGCCTTTCTCATTTGTCTTTTTACAGGAAACTTGCCTTCTCGTTTGAGGGATC CTTTTGCAGGAATGCGCGAGTCCTTGAATAAATTTGGCTTGGTGACGGCAGTATTCTTTCTCAGTAGACACTGCCACTTC CTCCACGCACCTTTCTACCCTGACTTAAGTTTCTCAGTGTTAATCACTATGACAAGTGAGAGCATTTGTCCCTTCCACAC TTTCCTGCCACTAGGTATCCCCTCCCTTCTTTTGCCTGTTTGAGGTGGAAAAGGGGCTAAACAGGTGCAGCTGTGAAGGA AATGGGGACCCCAGGAGCAACACTCCTGGAAGTACAACCTTAGCTTCTGTTGGGTTCTTATCTAACTCTGTTGCTATTGG CAGACTTTCCGGAAGCTGCTGGGGGATGTCTGACTAGCTCTCATGGAGCTCCACTACCTTGCTAAGAAGAGCAACCAGGC AGACCTCTGTGATGCCAGGGACTGGAGTTCAAGAGGGCTGCCTGGTGACCAGGCAGATACAGCAGCCACAAGAGCTGCTC TCTGCTGTCAGAAACAGTGTGCATCCACCCCAAGAGCAACCGAGATGGAAGGGTCTAAACTTAGTTCTTCTCCAGCATCC CCCTCCTCCTCTCTGCAAAACAGTACTCTTCAGCCAGATGCCTTTCCACCAGGACTTCTCCACTCAGGGAACAACCAAAT AACAGCGGAACGGAAAGTCTGTAACTGCTGCAGCCAGGAATTAGAAACTTCTTTTACCTATGTGGACAAAAACATCAACT TGGAGCAGCGGAACCGGAGCTCGCCATCAGCAAAAGGGCATAATCACCCTGGGGAGCTTGGCTGGGAAAATCCAAATGAG TGGTCCCAAGAGGCTGCCATATCTTTGATATCTGAAGAGGAGGATGATACAAGTTCAGAAGCCACGTCTTCAGGGAAGTC TATAGACTATGGTTTCATCAGCGCCATCTTGTTCTTGGTCACTGGGATCCTGCTCGTGATCATCTCTTACATCGTCCCAC GGGAAGTGACTGTGGACCCCAACACTGTGGCAGCCCGGGAGATGGAGCGCCTGGAGAAGGAGAGTGCGAGGCTGGGGGCT CACCTGGACCGCTGTGTGATTGCGGGGCTCTGCCTCCTCACGCTGGGGGGCGTCATCCTGTCCTGCTTGTTAATGATGTC CATGTGGAAGGGGGAGCTCTATCGTCGAAACAGATTTGCCTCTTCCAAAGAGTCTGCAAAACTCTATGGTTCTTTCAACT TCAGGATGAAAACCAGCACGAATGAAAACACTCTGGAACTGTCCTTGGTAGAGGAAGATGCGCTTGCTGTACAGAGTTAA TTCTGGTTGTGAATATCTTGAGAGTCTGCCTTGGCATTTTATAATATGAAAAAAGTTAATTTATAAAAATTCACAGTGCA ATTTATTTGCCTGGCAAGAAAAGTTTATTTCACAAACCAACAGCCAGTAAGTGTTTTTGTTCTCTATGTGTCTTCTATTT AGAAGAAAAGCCATGTAAGATGTATAAGAAACCACAACCAGCCACACCTATCCTTCTGAAGAGCTGAAGGCTAATTAATC TGTAATGGCCAAGAACTTCTACTTCGATAGAAAAATATTTCTAATGACCCAGTCTACAAATTATTTCTTTTACACAAATA TATGATGTTATTCTTTGGACACTAGGTGGTCCTACACACAGTAGGATCAATTGCTAATCTACTTTGTGAAAAAGAACTAA GCACTAATCAATAATAAGGCTTACATCTAATTCTCAAAGGTGCTTATCCATTTTCTTGCTAAATTATCCTTCTTGTAATT TGGCTAAACACTAAAACATGGAATTTTTAGTTTGAATATTTTGAAGTTTGAGGATGTTGGGCTTTCCTTATTGTAAAAAA TGTTATGTTTGAAATTATTCCTGTTTTCAAAAATGGTAATTAAGTCATTAGGATAAACTTTCTAATAAAAAAAAATTATG TAAATCATTGTAAGACCAATGTGAATTTAAACCACAGTGTTGGTGCCAGATATTAGCCAGGGTCACAGGCTCTTTTTTAA AATGAAGTCAAATTAGTTACTGATATAAGTTTTATATTTTGTGATTTTGCCATCATACTGGTTATCTGTGCTCTTGAAGT CTGCTGGTTCTCACACCAGCAGCAAGAGGCAAGGCATGAGACATTTTAAATATATTTCCAGACATCTAAACATCTAGACA GGCCTGAGTCATGATTGGCTCTGGTGTGCTTCCAGGTAACATCTTGTTATTGCTGTTTGGGGAAAACCACCAATAGAATT GCAGCTAGACTTTTGGGGACTGTGCCTCGCAGGCTGTATCACTTGCTGTAGGCCAAGCAACGAGCACTTCCCTCATGGTA GCAACAGTCCTTAAGCCCAAAGCCA

TMEM74, mRNA isoform 1 - Generality

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Primary source

RefSeq : NM_153015.1 (GI:23308544)

Name

Transmembrane protein 74 (TMEM74)

Type of transcript

mRNA

Organism

Homo sapiens

Length

2087 nt

Map

8q23.1

Location

Chromosome 8 (NC_000008.10) strand : -

109795345...109797365

109799704...109799769

Exon(s)

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Exon(s)	Start	End	Length	is coding
Exon 1	1	66	66	1
Exon 2	67	2087	2021	1

Variation(s)

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ID	Class	Location	Mutation	Length	is synonymous	Source
rs61753733	SNP	378	c/t	1	?	dbSNP
rs61753521	SNP	770	c/t	1	?	dbSNP
rs13277037	SNP	1449	g/t	1	?	dbSNP
rs62509434	SNP	1589	c/t	1	?	dbSNP
rs73313563	SNP	2050	c/t	1	?	dbSNP

CDS

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Primary source

NCBI : CCDS6310

Nucleotide

TMEM74, mRNA isoform 1[NM_153015.1] : 106...1023

Length

918

Location

Chromosome 8 (NC_000008.10) strand : -

109796409...109797326

Start codon

Translation

NP_694560.1

Sequence

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	FASTA

1	TTTCTCCGGG	AACCGTGCCG	GGAGAGCGCG	CGGTGCTGGA	GCCGCACCGG	GTGGCCGAAG	CAGAAGACTT	TCCGGAAGCT
81	GCTGGGGGAT	GTCTGACTAG	CTCTCATGGA	GCTCCACTAC	CTTGCTAAGA	AGAGCAACCA	GGCAGACCTC	TGTGATGCCA
161	GGGACTGGAG	TTCAAGAGGG	CTGCCTGGTG	ACCAGGCAGA	TACAGCAGCC	ACAAGAGCTG	CTCTCTGCTG	TCAGAAACAG
241	TGTGCATCCA	CCCCAAGAGC	AACCGAGATG	GAAGGGTCTA	AACTTAGTTC	TTCTCCAGCA	TCCCCCTCCT	CCTCTCTGCA
321	AAACAGTACT	CTTCAGCCAG	ATGCCTTTCC	ACCAGGACTT	CTCCACTCAG	GGAACAACCA	AATAACAGCG	GAACGGAAAG
401	TCTGTAACTG	CTGCAGCCAG	GAATTAGAAA	CTTCTTTTAC	CTATGTGGAC	AAAAACATCA	ACTTGGAGCA	GCGGAACCGG
481	AGCTCGCCAT	CAGCAAAAGG	GCATAATCAC	CCTGGGGAGC	TTGGCTGGGA	AAATCCAAAT	GAGTGGTCCC	AAGAGGCTGC
561	CATATCTTTG	ATATCTGAAG	AGGAGGATGA	TACAAGTTCA	GAAGCCACGT	CTTCAGGGAA	GTCTATAGAC	TATGGTTTCA
641	TCAGCGCCAT	CTTGTTCTTG	GTCACTGGGA	TCCTGCTCGT	GATCATCTCT	TACATCGTCC	CACGGGAAGT	GACTGTGGAC
721	CCCAACACTG	TGGCAGCCCG	GGAGATGGAG	CGCCTGGAGA	AGGAGAGTGC	GAGGCTGGGG	GCTCACCTGG	ACCGCTGTGT
801	GATTGCGGGG	CTCTGCCTCC	TCACGCTGGG	GGGCGTCATC	CTGTCCTGCT	TGTTAATGAT	GTCCATGTGG	AAGGGGGAGC
881	TCTATCGTCG	AAACAGATTT	GCCTCTTCCA	AAGAGTCTGC	AAAACTCTAT	GGTTCTTTCA	ACTTCAGGAT	GAAAACCAGC
961	ACGAATGAAA	ACACTCTGGA	ACTGTCCTTG	GTAGAGGAAG	ATGCGCTTGC	TGTACAGAGT	TAATTCTGGT	TGTGAATATC
1041	TTGAGAGTCT	GCCTTGGCAT	TTTATAATAT	GAAAAAAGTT	AATTTATAAA	AATTCACAGT	GCAATTTATT	TGCCTGGCAA
1121	GAAAAGTTTA	TTTCACAAAC	CAACAGCCAG	TAAGTGTTTT	TGTTCTCTAT	GTGTCTTCTA	TTTAGAAGAA	AAGCCATGTA
1201	AGATGTATAA	GAAACCACAA	CCAGCCACAC	CTATCCTTCT	GAAGAGCTGA	AGGCTAATTA	ATCTGTAATG	GCCAAGAACT
1281	TCTACTTCGA	TAGAAAAATA	TTTCTAATGA	CCCAGTCTAC	AAATTATTTC	TTTTACACAA	ATATATGATG	TTATTCTTTG
1361	GACACTAGGT	GGTCCTACAC	ACAGTAGGAT	CAATTGCTAA	TCTACTTTGT	GAAAAAGAAC	TAAGCACTAA	TCAATAATAA
1441	GGCTTACATC	TAATTCTCAA	AGGTGCTTAT	CCATTTTCTT	GCTAAATTAT	CCTTCTTGTA	ATTTGGCTAA	ACACTAAAAC
1521	ATGGAATTTT	TAGTTTGAAT	ATTTTGAAGT	TTGAGGATGT	TGGGCTTTCC	TTATTGTAAA	AAATGTTATG	TTTGAAATTA
1601	TTCCTGTTTT	CAAAAATGGT	AATTAAGTCA	TTAGGATAAA	CTTTCTAATA	AAAAAAAATT	ATGTAAATCA	TTGTAAGACC
1681	AATGTGAATT	TAAACCACAG	TGTTGGTGCC	AGATATTAGC	CAGGGTCACA	GGCTCTTTTT	TAAAATGAAG	TCAAATTAGT
1761	TACTGATATA	AGTTTTATAT	TTTGTGATTT	TGCCATCATA	CTGGTTATCT	GTGCTCTTGA	AGTCTGCTGG	TTCTCACACC
1841	AGCAGCAAGA	GGCAAGGCAT	GAGACATTTT	AAATATATTT	CCAGACATCT	AAACATCTAG	ACAGGCCTGA	GTCATGATTG
1921	GCTCTGGTGT	GCTTCCAGGT	AACATCTTGT	TATTGCTGTT	TGGGGAAAAC	CACCAATAGA	ATTGCAGCTA	GACTTTTGGG
2001	GACTGTGCCT	CGCAGGCTGT	ATCACTTGCT	GTAGGCCAAG	CAACGAGCAC	TTCCCTCATG	GTAGCAACAG	TCCTTAAGCC
2081	CAAAGCC

	>gi\|23308544\|ref\|NM_153015.1\|Transmembrane protein 74 (TMEM74) TTTCTCCGGGAACCGTGCCGGGAGAGCGCGCGGTGCTGGAGCCGCACCGGGTGGCCGAAGCAGAAGACTTTCCGGAAGCT GCTGGGGGATGTCTGACTAGCTCTCATGGAGCTCCACTACCTTGCTAAGAAGAGCAACCAGGCAGACCTCTGTGATGCCA GGGACTGGAGTTCAAGAGGGCTGCCTGGTGACCAGGCAGATACAGCAGCCACAAGAGCTGCTCTCTGCTGTCAGAAACAG TGTGCATCCACCCCAAGAGCAACCGAGATGGAAGGGTCTAAACTTAGTTCTTCTCCAGCATCCCCCTCCTCCTCTCTGCA AAACAGTACTCTTCAGCCAGATGCCTTTCCACCAGGACTTCTCCACTCAGGGAACAACCAAATAACAGCGGAACGGAAAG TCTGTAACTGCTGCAGCCAGGAATTAGAAACTTCTTTTACCTATGTGGACAAAAACATCAACTTGGAGCAGCGGAACCGG AGCTCGCCATCAGCAAAAGGGCATAATCACCCTGGGGAGCTTGGCTGGGAAAATCCAAATGAGTGGTCCCAAGAGGCTGC CATATCTTTGATATCTGAAGAGGAGGATGATACAAGTTCAGAAGCCACGTCTTCAGGGAAGTCTATAGACTATGGTTTCA TCAGCGCCATCTTGTTCTTGGTCACTGGGATCCTGCTCGTGATCATCTCTTACATCGTCCCACGGGAAGTGACTGTGGAC CCCAACACTGTGGCAGCCCGGGAGATGGAGCGCCTGGAGAAGGAGAGTGCGAGGCTGGGGGCTCACCTGGACCGCTGTGT GATTGCGGGGCTCTGCCTCCTCACGCTGGGGGGCGTCATCCTGTCCTGCTTGTTAATGATGTCCATGTGGAAGGGGGAGC TCTATCGTCGAAACAGATTTGCCTCTTCCAAAGAGTCTGCAAAACTCTATGGTTCTTTCAACTTCAGGATGAAAACCAGC ACGAATGAAAACACTCTGGAACTGTCCTTGGTAGAGGAAGATGCGCTTGCTGTACAGAGTTAATTCTGGTTGTGAATATC TTGAGAGTCTGCCTTGGCATTTTATAATATGAAAAAAGTTAATTTATAAAAATTCACAGTGCAATTTATTTGCCTGGCAA GAAAAGTTTATTTCACAAACCAACAGCCAGTAAGTGTTTTTGTTCTCTATGTGTCTTCTATTTAGAAGAAAAGCCATGTA AGATGTATAAGAAACCACAACCAGCCACACCTATCCTTCTGAAGAGCTGAAGGCTAATTAATCTGTAATGGCCAAGAACT TCTACTTCGATAGAAAAATATTTCTAATGACCCAGTCTACAAATTATTTCTTTTACACAAATATATGATGTTATTCTTTG GACACTAGGTGGTCCTACACACAGTAGGATCAATTGCTAATCTACTTTGTGAAAAAGAACTAAGCACTAATCAATAATAA GGCTTACATCTAATTCTCAAAGGTGCTTATCCATTTTCTTGCTAAATTATCCTTCTTGTAATTTGGCTAAACACTAAAAC ATGGAATTTTTAGTTTGAATATTTTGAAGTTTGAGGATGTTGGGCTTTCCTTATTGTAAAAAATGTTATGTTTGAAATTA TTCCTGTTTTCAAAAATGGTAATTAAGTCATTAGGATAAACTTTCTAATAAAAAAAAATTATGTAAATCATTGTAAGACC AATGTGAATTTAAACCACAGTGTTGGTGCCAGATATTAGCCAGGGTCACAGGCTCTTTTTTAAAATGAAGTCAAATTAGT TACTGATATAAGTTTTATATTTTGTGATTTTGCCATCATACTGGTTATCTGTGCTCTTGAAGTCTGCTGGTTCTCACACC AGCAGCAAGAGGCAAGGCATGAGACATTTTAAATATATTTCCAGACATCTAAACATCTAGACAGGCCTGAGTCATGATTG GCTCTGGTGTGCTTCCAGGTAACATCTTGTTATTGCTGTTTGGGGAAAACCACCAATAGAATTGCAGCTAGACTTTTGGG GACTGTGCCTCGCAGGCTGTATCACTTGCTGTAGGCCAAGCAACGAGCACTTCCCTCATGGTAGCAACAGTCCTTAAGCC CAAAGCC

TMEM74 - Exon 1

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Exon number	1
Length	66 nt
Location	Chromosome 8 (NC_000008.10) : 109799704...109799769 (-)
Is part of	TMEM74, mRNA isoform 1 (NM_153015.1)
Sequence	Show
	TTTCTCCGGGAACCGTGCCGGGAGAGCGCGCGGTGCTGGAGCCGCACCGGGTGGCCGAAGCAGAAG

TMEM74 - Exon 2

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Exon number	2
Length	2021 nt
Location	Chromosome 8 (NC_000008.10) : 109795345...109797365 (-)
Is part of	TMEM74, mRNA isoform 1 (NM_153015.1)
Sequence	Show
	ACTTTCCGGAAGCTGCTGGGGGATGTCTGACTAGCTCTCATGGAGCTCCACTACCTTGCTAAGAAGAGCAACCAGGCAGA CCTCTGTGATGCCAGGGACTGGAGTTCAAGAGGGCTGCCTGGTGACCAGGCAGATACAGCAGCCACAAGAGCTGCTCTCT GCTGTCAGAAACAGTGTGCATCCACCCCAAGAGCAACCGAGATGGAAGGGTCTAAACTTAGTTCTTCTCCAGCATCCCCC TCCTCCTCTCTGCAAAACAGTACTCTTCAGCCAGATGCCTTTCCACCAGGACTTCTCCACTCAGGGAACAACCAAATAAC AGCGGAACGGAAAGTCTGTAACTGCTGCAGCCAGGAATTAGAAACTTCTTTTACCTATGTGGACAAAAACATCAACTTGG AGCAGCGGAACCGGAGCTCGCCATCAGCAAAAGGGCATAATCACCCTGGGGAGCTTGGCTGGGAAAATCCAAATGAGTGG TCCCAAGAGGCTGCCATATCTTTGATATCTGAAGAGGAGGATGATACAAGTTCAGAAGCCACGTCTTCAGGGAAGTCTAT AGACTATGGTTTCATCAGCGCCATCTTGTTCTTGGTCACTGGGATCCTGCTCGTGATCATCTCTTACATCGTCCCACGGG AAGTGACTGTGGACCCCAACACTGTGGCAGCCCGGGAGATGGAGCGCCTGGAGAAGGAGAGTGCGAGGCTGGGGGCTCAC CTGGACCGCTGTGTGATTGCGGGGCTCTGCCTCCTCACGCTGGGGGGCGTCATCCTGTCCTGCTTGTTAATGATGTCCAT GTGGAAGGGGGAGCTCTATCGTCGAAACAGATTTGCCTCTTCCAAAGAGTCTGCAAAACTCTATGGTTCTTTCAACTTCA GGATGAAAACCAGCACGAATGAAAACACTCTGGAACTGTCCTTGGTAGAGGAAGATGCGCTTGCTGTACAGAGTTAATTC TGGTTGTGAATATCTTGAGAGTCTGCCTTGGCATTTTATAATATGAAAAAAGTTAATTTATAAAAATTCACAGTGCAATT TATTTGCCTGGCAAGAAAAGTTTATTTCACAAACCAACAGCCAGTAAGTGTTTTTGTTCTCTATGTGTCTTCTATTTAGA AGAAAAGCCATGTAAGATGTATAAGAAACCACAACCAGCCACACCTATCCTTCTGAAGAGCTGAAGGCTAATTAATCTGT AATGGCCAAGAACTTCTACTTCGATAGAAAAATATTTCTAATGACCCAGTCTACAAATTATTTCTTTTACACAAATATAT GATGTTATTCTTTGGACACTAGGTGGTCCTACACACAGTAGGATCAATTGCTAATCTACTTTGTGAAAAAGAACTAAGCA CTAATCAATAATAAGGCTTACATCTAATTCTCAAAGGTGCTTATCCATTTTCTTGCTAAATTATCCTTCTTGTAATTTGG CTAAACACTAAAACATGGAATTTTTAGTTTGAATATTTTGAAGTTTGAGGATGTTGGGCTTTCCTTATTGTAAAAAATGT TATGTTTGAAATTATTCCTGTTTTCAAAAATGGTAATTAAGTCATTAGGATAAACTTTCTAATAAAAAAAAATTATGTAA ATCATTGTAAGACCAATGTGAATTTAAACCACAGTGTTGGTGCCAGATATTAGCCAGGGTCACAGGCTCTTTTTTAAAAT GAAGTCAAATTAGTTACTGATATAAGTTTTATATTTTGTGATTTTGCCATCATACTGGTTATCTGTGCTCTTGAAGTCTG CTGGTTCTCACACCAGCAGCAAGAGGCAAGGCATGAGACATTTTAAATATATTTCCAGACATCTAAACATCTAGACAGGC CTGAGTCATGATTGGCTCTGGTGTGCTTCCAGGTAACATCTTGTTATTGCTGTTTGGGGAAAACCACCAATAGAATTGCA GCTAGACTTTTGGGGACTGTGCCTCGCAGGCTGTATCACTTGCTGTAGGCCAAGCAACGAGCACTTCCCTCATGGTAGCA ACAGTCCTTAAGCCCAAAGCC

Q96NL1 - Generality

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Primary source	Uniprot : Q96NL1
Name	Transmembrane protein 74
Alternative name(s)
Synonym(s)
Organism	Homo sapiens
Length	305 aa
Protein existence	---

External Links

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ArrayExpress	Q96NL1
Refseq	NP_694560.1
Uniprot	Q96NL1
KEGG	hsa:157753

General annotation (Comments)

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Function	Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.
Subcellular location	Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in heart, lung, and placenta.

Ontologies

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Biological process	autophagy [GO:0006914]
Cellular component	autophagic vacuole membrane [GO:0000421] lysosomal membrane [GO:0005765] integral to membrane [GO:0016021] cytoplasmic vesicle [GO:0031410]

Binary interactions

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With	Uniprot accession	IntAct

Alternative product(s)

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Sequence annotation

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Feature key	Position	Length	Description	Feature identifier
Region
Transmembrane	178 - 198	21	Helical; (Potential)	Q96NL1-TRANSMEM-178
Transmembrane	232 - 252	21	Helical; (Potential)	Q96NL1-TRANSMEM-232

Sequence

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	FASTA

1	MELHYLAKKS	NQADLCDARD	WSSRGLPGDQ	ADTAATRAAL	CCQKQCASTP	RATEMEGSKL	SSSPASPSSS	LQNSTLQPDA
81	FPPGLLHSGN	NQITAERKVC	NCCSQELETS	FTYVDKNINL	EQRNRSSPSA	KGHNHPGELG	WENPNEWSQE	AAISLISEEE
161	DDTSSEATSS	GKSIDYGFIS	AILFLVTGIL	LVIISYIVPR	EVTVDPNTVA	AREMERLEKE	SARLGAHLDR	CVIAGLCLLT
241	LGGVILSCLL	MMSMWKGELY	RRNRFASSKE	SAKLYGSFNF	RMKTSTNENT	LELSLVEEDA	LAVQS