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| Primary source |
Uniprot : P35638
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| Name |
DNA damage-inducible transcript 3 protein
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| Alternative name(s) |
C/EBP-homologous protein
C/EBP-homologous protein 10
Growth arrest and DNA damage-inducible protein GADD153
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| Synonym(s) |
CHOP
CHOP-10
DDIT-3
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| Organism |
Homo sapiens
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| Length |
169 aa
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| Protein existence |
---
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General annotation (Comments)
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top
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Disease
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Note=A chromosomal aberration involving DDIT3 is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with FUS.
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Function
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Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA.
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Similarity
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Belongs to the bZIP family.
Contains 1 bZIP domain.
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Subcellular location
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Nucleus.
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Subunit
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Heterodimer.
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Biological process
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regulation of transcription, DNA-dependent [GO:0006355]
response to DNA damage stimulus [GO:0006974]
cell cycle arrest [GO:0007050]
mRNA transcription from RNA polymerase II promoter [GO:0042789]
regulation of transcription in response to stress [GO:0043620]
cell redox homeostasis [GO:0045454]
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Cellular component
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nucleus [GO:0005634]
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Molecular function
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transcription factor activity [GO:0003700]
transcription corepressor activity [GO:0003714]
sequence-specific DNA binding [GO:0043565]
protein dimerization activity [GO:0046983]
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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Feature key |
Position
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Length
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Description
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Feature identifier
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Region
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Compositional bias
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93 - 97
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5
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Poly-Glu
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P35638-COMPBIAS-93
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Domain
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134 - 148
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15
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Leucine-zipper
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P35638-DOMAIN-134
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Natural variations
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Natural variant site
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115 - 115
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1
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A -> V (in a colorectal cancer sample; somatic mutation)
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VAR_036000
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| 1 |
MAAESLPFSF |
GTLSSWELEA |
WYEDLQEVLS |
SDENGGTYVS |
PPGNEEEESK |
IFTTLDPASL |
AWLTEEEPEP |
AEVTSTSQSP |
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HSPDSSQSSL |
AQEEEEEDQG |
RTRKRKQSGH |
SPARAGKQRM |
KEKEQENERK |
VAQLAEENER |
LKQEIERLTR |
EVEATRRALI |
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DRMVNLHQA |
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>sp|P35638|DDIT3_human DNA damage-inducible transcript 3 protein
MAAESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTSQSP
HSPDSSQSSLAQEEEEEDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRALI
DRMVNLHQA
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| Primary source |
Uniprot : Q53YD1
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| Name |
DNA-damage-inducible transcript 3 [submitted name]
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| Alternative name(s) |
DNA-damage-inducible transcript 3, isoform CRA_a [submitted name]
cDNA, FLJ94723, Homo sapiens DNA-damage-inducible transcript 3 (DDIT3), mRNA [submitted name]
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| Synonym(s) |
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| Organism |
Homo sapiens
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| Length |
169 aa
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| Protein existence |
---
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General annotation (Comments)
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top
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Similarity
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Belongs to the bZIP family.
Contains 1 bZIP domain.
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Cellular component
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nucleus [GO:0005634]
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Molecular function
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sequence-specific DNA binding [GO:0043565]
protein dimerization activity [GO:0046983]
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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| 1 |
MAAESLPFSF |
GTLSSWELEA |
WYEDLQEVLS |
SDENGGTYVS |
PPGNEEEESK |
IFTTLDPASL |
AWLTEEEPEP |
AEVTSTSQSP |
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HSPDSSQSSL |
AQEEEEEDQG |
RTRKRKQSGH |
SPARAGKQRM |
KEKEQENERK |
VAQLAEENER |
LKQEIERLTR |
EVEATRRALI |
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DRMVNLHQA |
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>sp|Q53YD1|Q53YD1_human DNA-damage-inducible transcript 3 [submitted name]
MAAESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTSQSP
HSPDSSQSSLAQEEEEEDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRALI
DRMVNLHQA
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