(SIRT2) sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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10317
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Official symbol
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SIRT2
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Official name
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sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 19 (NC_000019.9) : 39369199...39390360 (-)
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Map
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19q13
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Length
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21162 nt
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NM_012237.2
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SIRT2, mRNA isoform 1
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NM_030593.1
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SIRT2, mRNA isoform 2
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Accession
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Name
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Organism
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Length
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Q8IXJ6
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NAD-dependent deacetylase sirtuin-2
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Homo sapiens
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389 aa
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Synonyms |
SIR2L2; SIR2; SIR2L
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Alternative name(s) |
silent information regulator 2; sirtuin type 2; sir2-related protein type 2; silencing information regulator 2-like; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
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Summary |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl
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1 |
TGTTGTACGA |
AAGCGCGTCT |
GCGGCCGCAA |
TGTCTGCTGA |
GAGTTGTAGT |
TCTGTGCCCT |
ATCACGGCCA |
CTCCCATTTC |
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81 |
TGGTGCCGTC |
ACGGGACAGA |
GCAGTCGGTG |
ACAGGACAGA |
GCAGTCGGTG |
ACGGGACACA |
GTGGTTGGTG |
ACGGGACAGA |
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161 |
GCGGTCGGTG |
ACAGCCTCAA |
GGGCTTCAGC |
ACCGCGCCCA |
TGGCAGAGCC |
AGACCGTGAG |
TCGGGGATCC |
GGGTAGGAGG |
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241 |
GTCGGGCCGC |
GCCGGGGCCT |
GGCTGAATGC |
TGCAGGCCCC |
GGGGCCCAAG |
GGTGGCCGCG |
GTGGGGCGGG |
AAGTAGGGAG |
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321 |
CGCTTCGGGG |
AGTGGGATTC |
TGAGGGCTGT |
TGCTTAGCGA |
TCTGTATCGC |
TAGGCTGGTG |
GGTTTCTGGG |
TCGCAGTGTG |
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401 |
TTCAGGGTTC |
GTTTACCACA |
TCCACTTGCC |
AAGTTGCCAA |
TGATCGCGTG |
TTTCTCGCAC |
CTTGGTTGCT |
AAGGTCCCTC |
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481 |
GCTGCAAAGA |
ACATAAGTTG |
CCCCGGTCCC |
GCTTGCTATG |
GGTACCTGAT |
TGTTAGAGGC |
AACCAGAGGA |
TGCTGAGGGA |
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561 |
CCCCTGCTGA |
CCCCTCCTAT |
GGCTTCCCCT |
TGTTCCGCGC |
CTCTCCTAAA |
CCTACCGCCT |
CCACTGCACC |
ACTGCACCTC |
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641 |
CCTCCTAAAC |
CTGCCTCCCA |
GCCAAAGCGT |
CTCTTCCCTT |
CTCTTTTCCT |
TTCTAAACTT |
CCCTCTGCCT |
TGTAAATCTA |
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721 |
ACCCTCCCCG |
CACACACACT |
CACACACTGT |
CGTGTCCTTC |
CTAACTCCTC |
CTGAGTGTTC |
CTTCATGCCC |
TGAATCCCCT |
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801 |
AGGTAGGAGG |
AGGAGGATCG |
CTTGAGCCCA |
GGAATTTGAG |
GCTGCAGTGA |
GCTATGATCG |
CACTATTGCA |
CTCCAACCTG |
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881 |
GGTGACATGA |
GCGAGACCCT |
TTCTCTAAAA |
AGTAAAAAAG |
AAAGAAAGTA |
AGTCAGGGCC |
AGAAACAATG |
GCTCATGCTT |
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961 |
GTAATCCCAG |
TACTTTGGGA |
GGCCAAGGTG |
GTTGGATCGC |
TTGAGCCCAG |
GAGTTCAAGA |
CCAGCCTGGG |
CAAAAGCCCC |
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1041 |
TACTTTCTCC |
CTGTCCCCCT |
AAATCTTCCT |
CTCCAGCCTC |
TCTGCCCCTC |
ACTAATCACC |
TCTCCCGGCA |
TCACTTTGCA |
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1121 |
TGTAGATAAG |
ATCTTTTCTC |
CGTCCCCTCC |
CTCCCTCTGC |
TCCATTTTTA |
CCACCATCCC |
ATCCCAGTGT |
AACTAGGTTG |
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1201 |
GTGGGTGTTC |
TTGCCCCCTC |
ACTGACCATT |
TGAACCCCTT |
TATTCCCCCC |
TTAATCGTTC |
TCCCCACTGT |
AACCACCTCT |
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1281 |
GCTCCCCTCC |
CCCAGCCTCT |
CACCCTCTGG |
AGACCCAGGC |
AGGGAAGGTG |
CAGGAGGCTC |
AGGTGAGATG |
GGGGAAAGGG |
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1361 |
TGGAGGGGAG |
GAGAGAGACG |
GACTTGTTCC |
ACATCCCACA |
CTGGGGGGAG |
GTGGCAAAGG |
GGAAACAGTC |
ACCCCAGGGC |
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1441 |
CCTCGGCTCA |
TTGCCCCAAT |
CCCTCACACC |
ACCCAGTGCA |
GCTTTCTGGG |
GAAAGGCAGA |
TTCTGGGGAT |
TGTCAGAGAA |
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1521 |
GAGTTTCCAG |
CCTCAAGTCC |
AGGCCTGTCC |
TCCCAAACTT |
TCCTTCTTCC |
TTGCCACTGC |
CTGCCATCCC |
TTCTGAACCA |
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1601 |
CATTTGTCCT |
GGGACTGGAA |
GAGACAGGTA |
TCCCATTTGG |
TCTTGGAACG |
CACAGATCTC |
GTGGACAAGT |
GATGGGAAAA |
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1681 |
AATGATCTCA |
CAGCGTGATG |
ACGAAAGTAA |
CTCAGGGGGC |
CAGATGCAGT |
GGCTTATGCC |
TGTAATTCCA |
ATAACTCAGG |
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1761 |
AGACTGAGGC |
GCGAGGATCG |
CTTGAGCCCA |
GGAGTTTGAG |
GCTGCAGTGA |
GCTATGATTG |
CATCACTGCA |
CTCCAGCCGG |
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1841 |
GGTGAAAGAG |
CAAGACCCTT |
TCTCTAAAAA |
GTAAAAAAGA |
AAGAAAGTAA |
CTCAGGGCCA |
GACACAGTGG |
CTCATGCTTG |
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1921 |
TAATCCCAGT |
ACTTTGGGAG |
GCTGAGGTAG |
GAGGATCGCT |
TGAGCCCAGG |
AGTTCCAGAC |
CAGTCTTGGC |
AACATAGGGA |
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2001 |
GGCCCCCACC |
TCTACAAAAT |
ATTTAAAAAT |
TAGCCATGTG |
TAGTGGTGCA |
TGCCTGCATT |
GCCAGCTACT |
CAGGAGGCTG |
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2081 |
AGTTGGGGGA |
GGATTGCTTA |
AGCCCAGGAG |
GTTAAGGCCG |
TAGTGTGCCT |
TGACTGTGCC |
ACTGCACCCC |
AACCGGGGCG |
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2161 |
ACAGAGCAAA |
ACACGGTCTC |
AAAAAAAAAA |
AAAGGAAGAA |
AAGTAAAGAA |
ACTCAGGGTA |
CTGTGGGAGC |
ACAGAGAAAA |
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2241 |
TTTTCTGGGT |
CAAAGAAGAT |
TCTAGCCAGG |
CCATTCCCTG |
GAGGAATCCA |
CAGGCTGGTC |
TAGCTGTCAG |
ACCAAGATAC |
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2321 |
AGACACAGCA |
TAAGTGAAGA |
GTGACTTAGA |
ATTTTCTTAG |
ACAAGGTGAG |
AAATGGTGAT |
CCACACAACA |
GGTATCGCTT |
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2401 |
GTGCAAAGAC |
CTGGGGGGCA |
TGAAGGGGTG |
TGATGTGTTC |
CATAATTGGG |
TGGCTGGTGG |
TGGTCAGCTT |
GTTATAGTCG |
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2481 |
TGGTTAGCAT |
TTACTGACGG |
CTTACTAAAG |
CTGGGCCCAC |
TGTTTAGTGC |
CAAACGTGCC |
TCATCTCAAT |
TTCATCTTCC |
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2561 |
TGGCATCCCT |
GTGAAGAGAA |
ACGCCTATCA |
CGGCCATTTT |
ACAGATGCAG |
AATCTGAGGC |
AGAGTTGTTA |
AGTCACTTAT |
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2641 |
CCCCCGTCCC |
TCGGCTACAG |
GAGCAGGGAA |
GGGTTTGAGT |
CCCCCAGCAC |
TGGGCACGCC |
ACCTGTCAGA |
GGCTGCCAGG |
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2721 |
AGAGGTGGAC |
AGGCAGTCTC |
ATAGGAGCTT |
GAAGGCCCCC |
GTCAGCACCT |
CCGGCTCTCC |
CTTAGGCCAA |
GCTGCAGACA |
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2801 |
CATGCTGGGC |
ACAGGCCTTC |
CACACAGCCT |
CACTGTGTAC |
AGCCTGAAAG |
AGTGCCAGCC |
CACCCACACC |
CCTGAGATTG |
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2881 |
CCTTTCAGAC |
GTGGGGTGGT |
GCAGAAGCGG |
GCATCAGAAT |
ACCTCACAAA |
TGCACAGTGG |
AGCTTTGCTA |
AGGATATAAG |
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2961 |
AGCCTCCTGT |
TAGGCTGTGG |
CAACTCACTC |
GCCTGGCTCC |
CAAAGCACGA |
CCACTGTCAG |
AGAAAAAGGT |
TGAATGTTAA |
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3041 |
AAAGGATCCT |
CAGTCCCAAA |
GAGAGAGAGG |
CGAGGATGTA |
AAATGCAGCA |
TTGTCCGTCA |
CAGGGCAAAA |
CTGGAAACAG |
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3121 |
TCCAAATGGC |
TGTCAGTGGA |
TGGGTTAAAT |
GAACTATGGT |
TCATCCATAC |
AATCCAATAC |
TATGTAGCTG |
CTCTGAAAAA |
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3201 |
CGAGGTGAGG |
CCGGGCACGG |
TGGCTCACAC |
CTGTAATCCC |
AGCACTTTGG |
GAGGCAGGGG |
GATCACTTGA |
GCCCAGGAGT |
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3281 |
TTTGAGACCA |
GCCTGGGCAA |
CATAGCAAGA |
TGCCGTCTCT |
TTTTTAAAAA |
ATTATTTTTT |
AAATTAGGTG |
GGTCTGTAGC |
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3361 |
ATATTGTTCT |
GCCGAAAACT |
CAAGATGTTG |
TATTGTACTA |
TGACCTATTT |
CTGTAAAAAA |
TATTAGTTTT |
ATGCAGAGAA |
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3441 |
AACTGGAGTA |
ATTTCCATTA |
AGCTTAGCTA |
ACAGTGGTTA |
TCTTTATAAG |
GGTGGGCTTG |
GGCAATTACA |
AGGTGAGTGC |
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3521 |
CGCAAGTTAT |
ATGTTGTTGA |
AGTATACATG |
AGTATAATCA |
AGGTTTTTGC |
AGAGGTTGTC |
CAATCTCTCT |
TTCTCTCTGT |
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3601 |
CTCTCTCTCT |
CTCTCATTCT |
CACTCTCTCT |
TTCTCTCTCT |
CTTTTTTTTT |
GAGACGGAGT |
CTCGCTCTGT |
CACCCAGGCT |
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3681 |
GGAGTGCAGT |
GGGGTGATCT |
CGCTGACTGC |
AACCTCCACC |
TCCCAGGTTC |
AAGCGATTCT |
CCTGCCTCAG |
CCTCCTGAAT |
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3761 |
AGCTGGGACT |
ACAGACACGT |
GCCACCATGC |
CTGGCTAATT |
TTTTGTATTT |
TTATTAGACA |
CGGGGTTTCA |
TCATGTTGGC |
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3841 |
CAGGATGGTC |
TCGATCTCCT |
GACCTCGTGA |
TCCACCCACC |
TCAGCCTCCC |
AAAGTGTTGG |
GATTACAGGC |
GTGAGCCACC |
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3921 |
GTGCTCAGCC |
TTTCTCTCTC |
TTTTTAAATA |
GAGACAGAGT |
CTCACTGTGT |
TGCCCAGGCT |
GGTCTTGAAC |
TCCTGGCATC |
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4001 |
AAGCAACCTT |
CCTGCCTCAG |
CCTCCCAAAG |
TGGTGGGATT |
ACAGGCATGA |
GCCACCACGC |
CCAGCCGGAG |
TTGCACAGTC |
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4081 |
TTAAAAAGCA |
ATTTTTTAAA |
TTGTCGTATG |
TTCGGAAGGG |
AGGGTCTTAT |
TCAAAAAGAC |
TTGGACGCAG |
AGCAGTGAGT |
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4161 |
ATCCGGGGAA |
GGGAGTTGTC |
TGAGGTGGTG |
GCTTGGTCAG |
AACTGCATTT |
TGGTGAAATC |
CATTGCAGGG |
CCCAGCCGTG |
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4241 |
GTCCAGCCTG |
AAGCAGGCAT |
TCATTCCAAG |
GTAGAGGAGC |
TCCTGGAGCT |
CCTGCCAGGA |
GCCAGACCCT |
GTTCTCAGTG |
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4321 |
CTGGGCACCC |
AGACAAAGTC |
CCTGCCCTTG |
TGGACATCCT |
GGCAATTCCA |
TAGATGTCTG |
GGAAGACTGC |
AGAAGCCAGA |
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4401 |
GAGAAGGGCC |
TTTGAAGTGG |
AGAGGGGCGA |
GCTGACCCAG |
ACAGCCTCAC |
ATGCAGGGCA |
GCAGGGTGGA |
TGGGAGGTGG |
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4481 |
AGACTGAGGC |
TGGGAGGCTG |
GGGGAGGAGG |
CTGGGGCAGG |
ACCCCCGGAG |
GAGAGGACAG |
GCTGGACCAG |
GTGGAGCGCC |
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4561 |
GGGGAGGGAA |
AGGGGGTTGG |
TGGACAGACC |
CTTAGGAGGC |
TCAGCGTACA |
TGCTCTGGAG |
CTGAAGGGCT |
GTGGCAGGAG |
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4641 |
GGCGAGGAGG |
GAGGCGGGGG |
CAGGAAACAT |
CTGGCTGATG |
GGGGGGACAG |
TACGATCGCA |
TTGAGATGAG |
GCCTGGGAGG |
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4721 |
AGGATGGGCT |
TGGAGGAGAT |
GCCAGGGTCC |
ATTTGGGACA |
TAGTAGGAGT |
GAGAGGCTGG |
GGGGCACCTA |
GGGCAAGGTG |
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4801 |
TCCAGGAAGC |
CAGGGAACCC |
CGGATCTGAG |
GGCAGAGAGA |
TGGTATCATG |
AGTGACGAGG |
CAGAGGTCAT |
TGGCATGGAT |
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4881 |
GAGACAGGTA |
ACCCCAGGAA |
AGTGGAAAGA |
GAAAGCAGAG |
AGGCCCTGGA |
CAGAGTCCCA |
GAGACCTGCC |
AGTCTGGAGC |
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4961 |
TGGGCTGAGG |
GGAGGCTTCG |
AGGAAGGAGA |
CAGAGGTTGC |
TGGAGAGGTG |
GGCAGAGTGT |
CTGAGGCCTC |
GAGCAGGGGG |
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5041 |
CACATAGGTC |
CTTGAAGTGA |
GGGCCAAGGC |
TTTGCATTGG |
AATCATTCCC |
AGAGTGACTT |
GGGACATTAT |
TCAGAGGCCC |
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5121 |
CCAGGGCTGC |
TGGGAAGGGA |
CAGCAGGCCC |
ACGCTCCAGG |
GGACCCGGGA |
ACGAAGGGAA |
GACCCCAGGC |
TGTGATAATA |
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5201 |
ACAGCAACAG |
CCAGCGCTTA |
CCAAGCACTT |
CCCCCGCCCC |
TGGTGCTGCG |
CCCAGCACCC |
AAGCTCCCTT |
TCCAAGGTGA |
|
5281 |
GGGACACCAA |
GACTTAGAAA |
ATCAAAGTCA |
CGACCAGGCA |
CAGTGGCTCA |
CGCCTGTAAT |
CCCAGCACTT |
TGGGAGGCCG |
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5361 |
AGGCAGGAGA |
CTTGCTTGAG |
CCCAGGAGTT |
CAAGACCACC |
CTGGGCAACA |
GAGGAAGACC |
TCGTCTCTAC |
AAAGCAAACA |
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5441 |
AACAAACAAA |
CAAAAAATGA |
GCCTGGCATG |
GTGGCACGTG |
CCTGTGGTCC |
CAGCTACTTG |
GGAGGCTGAG |
GTGGGAGGAT |
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5521 |
CCCTTGAGCT |
TGGGAGGTTG |
AGGCTGCAGC |
AAGCTGTGAC |
TGCACCAGTG |
CACTCCAGCC |
TGGGCAACAG |
AGCGAGACAC |
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5601 |
TGTCTCAAAA |
AAGAAAAGCA |
AAGCAAAGCC |
ACTCACATGA |
GGTCTTGCTC |
CTGGGGACGG |
GCATGGCCAG |
GACTCCAACC |
|
5681 |
CCGGCAGCCT |
GTCCCAGAGC |
CCTGGAGCTA |
GCCCCAGTGC |
AGTCTCTCCA |
CCACCCCGCA |
CTTCCTCAGG |
CCACCTTCCT |
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5761 |
GCCACAGCCT |
TTTCCCCAAA |
CCTGGTATCA |
CCCCCTCTCC |
TCCCTCCCTA |
ATCCCACCTC |
TCGGGCCTGG |
CCACTCCACC |
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5841 |
CCACCCCTTC |
CAGGACTCAG |
ATTCAGACTC |
TGAGGGAGGA |
GCCGCTGGTG |
GAGAAGCAGA |
CAGTGAGTAT |
CTTCCTGGAG |
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5921 |
GGACAGGGAG |
CAGGGTTCTG |
GGGGGCGGGG |
GGATTTCAGG |
GCAGGGGTGT |
GGGTGATACC |
TCCTCAACTC |
CATCAGGAGT |
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6001 |
GACATCCAAA |
GTATGTAGCA |
GTGGGTTGGG |
TACCAGTGCC |
AGAGCAGGCT |
CCTGGAGGCC |
GCTGGCTGGG |
CCGGGCCTTG |
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6081 |
TGCCTTTAGA |
TGTGGGGAGG |
CCGGGAACCC |
CAGGGCTGGG |
GCCAGGGTGC |
CGGAGACATC |
CATGCCCCTG |
GCTGAATGCC |
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6161 |
CGTCCTGCCG |
CTGTCTCTCT |
TCTTTCCGGT |
CAGTGGACTT |
CCTGCGGAAC |
TTATTCTCCC |
AGACGCTCAG |
CCTGGGCAGC |
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6241 |
CAGAAGGAGC |
GTCTGCTGGA |
CGAGCTGACC |
TTGGAAGGGG |
TGGCCCGGTA |
CATGCAGAGC |
GAACGCTGTG |
AGTCCCCTGT |
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6321 |
CAGGATTGGG |
CCACTTTGCC |
TGGCTCCTGG |
CCCCAAGTGA |
CCTCCCATCC |
CCAGCCACTT |
GAACCATTTA |
TTGAAACCTT |
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6401 |
TTCTTTATAA |
GTAGCAAGAA |
ACCCAGCTGG |
AACTGGCTTA |
AGCCAAAAAG |
GAGTGTGTTG |
GCTCTAATCC |
AGCTTGAAGC |
|
6481 |
ACGGCTGGGT |
CCAGGTGCTT |
CCACTTTGTT |
AAAAATCATA |
ACTCTCTCTG |
ATGCTGCTTT |
TCTTGTTTTG |
GGGTAAAGGT |
|
6561 |
AACTCCTGGC |
AGCTGCAAAT |
GCAGGTTCCA |
CTAGCCTAGG |
AGCTGCCACC |
GAGAGAGCAC |
CTTTTCCCAG |
TAGTTCAAAC |
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6641 |
CAAACAGCAG |
AGATTGGCTC |
CCATTGGTCC |
CGGTTGAGTC |
AAATGCCTGC |
CCCCATGCCT |
CTGATTGGCC |
AGACCTGGGT |
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6721 |
CGCTTCTCCA |
TTGCTGAGTG |
AATTACTGCA |
CTCTGATTGA |
CCAGGCCTGT |
TTCATAAAAT |
GAGGATAATG |
ATTATAGTAT |
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6801 |
CTAACTCATA |
AGGTTATTGG |
CGGGGCTAAA |
TAAATTAATA |
TAGGACCAGG |
GGCAGTGGCT |
CATGTATGTA |
ATCTCAGCAC |
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6881 |
TTTGGGAGGC |
CATCGTGGGA |
GGATCACTCA |
ACGCCAGGCG |
TTCAAGACCA |
GCCTGGGCAA |
CATAGTGAGA |
CCCCCCCGCC |
|
6961 |
ATCTCTACAA |
GAAAAAAAAA |
AATAGTCAGA |
TATGGGGGCG |
TTGCCTGTAG |
TCTCAGTTAC |
TCAGGAGGCT |
GAGAAGGGAG |
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7041 |
GATTGTTTGA |
GCCCAGGAAT |
TGGAGGCTGC |
AGTGAGCTAT |
GATGGCACCA |
CTGCACTGCA |
GCCTGGGCAA |
CACAGTGAGA |
|
7121 |
CTCTGACTCT |
AAAAAAAAAT |
AAAGTAATAA |
AATTTAAAAG |
ATAAATAAAA |
ATGCAAATGC |
TTAGAGCAGG |
GCCTGGAACA |
|
7201 |
TAGCGAGAGC |
TGTGGCAGGG |
TGTGCCGTGG |
TTATTACTAC |
AGGAGGCTTA |
TTTCAGATGT |
GGTGGATAGG |
TGTCCACTTA |
|
7281 |
CTGAGTCAGC |
ATGAAATTTA |
TATTTCTTTT |
TCTTTTTTTT |
TTTTTGAGAT |
GGAGTCTTGC |
TCTGTTGCCC |
AGGCTGGAGT |
|
7361 |
GCAGTGGCAC |
AATCTCAGCT |
CACTGCAACC |
TCCACCTCCC |
GGGTTCCAGC |
AATTCTCCTG |
CCTCAGCCTC |
CCGAGTGGCT |
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7441 |
GGGATTACAG |
ACGCACACCA |
CCACGACTGG |
CTAATTTTTT |
GTATTTTAGT |
AGAGACAGGG |
TTTCACCATG |
TTGCCCAGGC |
|
7521 |
TGGTCTTGAA |
CACCTGAGCT |
CAGGCAATCC |
ACCCTCCTCG |
GCCTCCCAAA |
GTGCTAGGAT |
TAGAGGCATG |
AACCACCCGT |
|
7601 |
CCCGGCCTGA |
AATTTATATT |
TCTTGCCACA |
AGTTGAGGTC |
ACCAAAGTCT |
GAGAAACCAG |
GCCCTTGGCA |
GTCCTCAACT |
|
7681 |
AGAACAATCG |
ACCCTTTGTG |
GTTCCTGAGC |
AGCCTTTTGT |
TGAGGACATC |
TTCTCCTGTG |
TCCCTGTCCT |
CCAGCTGCCA |
|
7761 |
CTGTCTCCCT |
CCTCAGGCAG |
CCAGGCCTGC |
TGCCCTGAGC |
CTCCCTCTCC |
TGCGGCAGGC |
GAGCAGCTGT |
CTGCAGCCAT |
|
7841 |
CTTTTAGCCT |
GGGCAGGCCC |
CAAAGACAAC |
ACAGGCAGTG |
GCTACAAAGC |
ATTTGTTCCT |
TGTGTCCTCC |
TGCACCTGGA |
|
7921 |
TTCTGGGGTA |
ATTGGCTCAT |
GAGGGTGCCC |
AGGAGGAGAT |
AGTAATGAAA |
AATAACAATT |
AGTTGAGGCC |
GGGAGTGGTG |
|
8001 |
GTTCAGGCCT |
ATAATCCCAC |
CATTTTGGGA |
GGCTGAAAGC |
AGGAGGATCG |
CTTGAGGCCA |
GTAGGTCAAG |
ACTAGCCTGG |
|
8081 |
GCAATAAGCG |
AGACCCCCTC |
TCTGCAAAAA |
TTTAAAGGTG |
AGGCTCCAAC |
CCTCACCTCA |
CTGCTCTAAA |
AATTTATTAT |
|
8161 |
TATTATTATT |
TTGAGACAGA |
GTCTCACTCT |
GTTACCCAGG |
CTGGAGTGCA |
GTGGCGCTAT |
CATGGCTCAC |
TGCAACCTCT |
|
8241 |
GCCTCCCGGG |
TTCAAGCGAT |
TCTCCTGCTT |
CAGCCTCCCG |
AGTAGCTGGG |
ATTACAGGCG |
CGTGCCACCA |
CGCCCGGCTA |
|
8321 |
ATTTTTGTAC |
TTTTAGTAGA |
GACGGGGTTT |
CACCATGTTA |
GCCAGGCTGG |
TCTTGAACTC |
CTGACCTCAG |
GTGATCTGCC |
|
8401 |
CCCCTCGGCC |
TCCCAAAGTG |
CTGGGATTAC |
AGGAGTGAGC |
CACCGGGCCC |
GGCCCTAAAA |
ATTTCTTTTT |
AACCACTTAA |
|
8481 |
TTGAGGCTTC |
ACTATTTGCC |
AGGCACTGGG |
CTCAGCACTT |
TACAAGTGCC |
CTATTATTTG |
ATATTCACAT |
TATACCTGTA |
|
8561 |
AGATCATTAT |
GGAAGTGATC |
TGAACAGAGG |
AGGAAAAGGA |
GGCACAAAAA |
GGTCACGACT |
CAGTGTAGGG |
TCAAACAGTT |
|
8641 |
GCCAAGTGGC |
AGAGCCAGGA |
TTTGACCCCA |
GGTCCCCTGA |
ATCCAGACCA |
CATGTAGCCA |
CCACTGGATT |
CAACCAGGCC |
|
8721 |
TGGCCTGATG |
GCATCTCAGA |
GCTGAAGCTC |
AGGGCTGAAG |
CTGTGGCAGG |
CTTTGTGCTC |
TGTTCACCTT |
TGCTGTCCTC |
|
8801 |
CCTTGGACAG |
GGCATCCCAG |
AGGCATCTGA |
TCCACAGCAT |
ATCACACTTG |
TGCCTGTCTA |
TCAGCTGATG |
GGCAGATGCC |
|
8881 |
AGGGTACTAT |
GGCCTGGTGG |
CTACTCACCA |
GCCACCAGCT |
AGCTATTTCT |
GCTCAGCCCA |
GGGTTCTTAT |
CCTAAAGTGG |
|
8961 |
CCTTTTCTCA |
AGTCCAAGTT |
GGTGTGATTT |
CCAACAGTGG |
ATTCTCTTTT |
TTTTTTTTTT |
TTCCTTTTTT |
TGAGATGGAG |
|
9041 |
TCTCGCTCTG |
TCACCCAGGC |
TAGAGTGCAA |
TGGCATGATC |
TCGGCTCACT |
GCAACCTCCG |
CCTCCCGGGT |
TCAAGTGATT |
|
9121 |
CTCCTGCCTC |
AGCCTCCCAA |
GTAGCTGAGA |
TTACAGGCAC |
GTGCCACCAC |
GCCTGGCTAA |
TTTTGTATTT |
TCAGTAGAGA |
|
9201 |
TGAGGTTTTG |
CCATGTTGGC |
CAGGCTGGGC |
TCAAACTCTT |
GACCTCAGAT |
GACCCGCCTG |
CCTCAGCCTC |
CCAAAGTTCT |
|
9281 |
GGGATTACAG |
GCATGAGCCA |
CTGCACCCAG |
CCCAACACTG |
GATTCTTTAT |
CCGCTGGCTG |
GCTCTTCCGC |
AGTTGATTGT |
|
9361 |
GTGACTTCTT |
CCCCTATCTG |
AGCCCCAGTT |
TTCTCATTTA |
TAAAATGGGG |
ATGTTAACAC |
CATCCCCGTC |
TAGATGATTG |
|
9441 |
GAAGGCCCGT |
CATGCATCTG |
AGATGCTTGC |
CCCAGGGCCT |
GGCATGGAGT |
AAACGATGTC |
AGGGGCTGTG |
ATGGGTGGTG |
|
9521 |
CTATCGTAGG |
GACTGAGCAA |
ACGGTGTCAT |
ATGGTGCATA |
AGTTCCTCTC |
CTCCAGGTCG |
CAGAGTCATC |
TGTTTGGTGG |
|
9601 |
GAGCTGGAAT |
CTCCACATGT |
AAGTAACCCT |
TCTCCCCCAG |
CAGCTACCCC |
CAGGAACTGG |
GGAGTCCCTC |
CCAAGGGCTG |
|
9681 |
GGGAGGAGCC |
CTATCTGAGC |
CCTGTCCTGG |
GAGGGTTAGT |
ATGGTATAGA |
CCAACTGCTC |
CCTGACCCCC |
CTTTCCTAGC |
|
9761 |
CGCAGGCATC |
CCCGACTTTC |
GCTCTCCATC |
CACCGGCCTC |
TATGACAACC |
TAGAGAAGTA |
CCATCTTCCC |
TACCCAGAGG |
|
9841 |
CCATCTTTGA |
GATCAGCTAT |
TTCAAGGTTT |
GTGCTCCCCC |
AGGAAGGGGC |
GTCTGTGAGG |
GGTGGGGATG |
GGGTCACCTG |
|
9921 |
GCTCCAACCC |
TCACGCTACC |
TGGGGCATCT |
GGCCCTCTGG |
CTGTCTCTCC |
TACAGAAACA |
TCCGGAACCC |
TTCTTCGCCC |
|
10001 |
TCGCCAAGGA |
ACTCTATCCT |
GGGCAGTTCA |
AGGTGAGATC |
TTTGTTTTGC |
AGGGGGCGAA |
ACAGGAAGGG |
TTGGGGGAGG |
|
10081 |
GCACGCATGA |
GAAGCCCCGC |
CAAGGCCCTG |
CAGACAAATA |
TTATGTAGCC |
ATTAAGTACA |
TGGGTGCTGG |
GCCCAGACTG |
|
10161 |
CCTCGGTTCA |
AGTCCTGGTT |
CCTCGTGTCT |
TCATCTTACG |
ACCTTGAGCC |
TCCGATTTGC |
CTCCTGTGAA |
GTGAAGCTAA |
|
10241 |
TGGTACTGTC |
TGAAGAGGGC |
TGCTGCGAGG |
CTTAGCTGAC |
TAATGATGCC |
GTTGAGAGCC |
CGGGACCCTG |
CAGCCGGGCT |
|
10321 |
GCCTGGGTGT |
GAATCTCAGC |
TCTGCAGCTT |
ACCCACCGTG |
TGACTTTGGC |
AACACAATCC |
CCTTCCCTGT |
CCTTCAGTTT |
|
10401 |
CCTCATCTGT |
GATCTGGGGA |
TAGCAGTGGT |
CTCTCCCCGA |
CGCGGCTGCT |
GTGACGGTTC |
CCTGGGGGTA |
AAACAGTCAC |
|
10481 |
AGTGCCTAGA |
ACAGTTCCTG |
GCATGCGGCA |
GTGGCCTGTG |
GCTGTTCCCT |
GCAGTCGTCA |
GCAGTGCTGT |
CGCTCTTCCC |
|
10561 |
TGCAGCCAAC |
CATCTGTCAC |
TACTTCATGC |
GCCTGCTGAA |
GGACAAGGGG |
CTACTCCTGC |
GCTGCTACAC |
GCAGGTAGGC |
|
10641 |
GGATGCGAGC |
ATCCTGGGAG |
GAGGATGGGC |
GGGTGGAACG |
GGCATGGTGT |
CCTCAGCAGA |
GGAGCAGAGC |
TGCGTGCCCA |
|
10721 |
AGAGCTCAGG |
CGGGGACTCC |
AGCAATGCGG |
GGCCAGGGCT |
TGGCCTACTG |
CCTCCTTGCT |
GCATGACCTG |
CCGTGAGTCA |
|
10801 |
CGTCTTCTCT |
GCCTCAGTTT |
CCCCTTCCGT |
CAAACAGGGG |
CCAGAAAAGG |
TTTGCCCTCT |
CAGGTCTGCC |
CTCTCAGGTC |
|
10881 |
TGCAGTGCGG |
TGGCAGTGAC |
CTCCTCTCAG |
GGCCATCCCA |
TGTGTGATGT |
GGAAGGAGCC |
TATGGCTGAA |
GGGACTCTGT |
|
10961 |
GTGCACTATA |
GGCACCCCAG |
ATTTCACATT |
GGTTATGAGC |
GAGTTTCCAA |
AGTGACTTCA |
TCTAACAAAA |
TCCATACACT |
|
11041 |
ATGACACGTG |
TCCAACAAGT |
AGATGTTGTG |
CCTTAAGGAA |
GGGGCACCTT |
TTTATAGTTT |
TTTGTGCTTT |
GCCCAATTAT |
|
11121 |
AAACATGTCT |
CGTACACGTC |
AGGTGCTTAG |
CCAAGGGCCT |
CTCCCTGGGG |
CATTCAAGCA |
AGGATGGCTC |
ACATTGTTGG |
|
11201 |
CTTCTGGTTT |
GGAGAGTCTC |
ACACCCCTAA |
CAGTAAAAAA |
ATCTTGATGG |
GCTGGGCACA |
GTGGCTCACA |
CCTGTAATCC |
|
11281 |
CAGCACTTTG |
GGAGGCCAAA |
GCGAGAGATA |
GCTCGAGCCC |
AGGCGTTTGG |
GACCCGCCTG |
GGCAACATAG |
GGAGACCCTG |
|
11361 |
TCTCTACAAG |
AAATACAAAA |
ATTAGCTGGG |
CAGGGTGGCG |
TGTGCCTGTA |
GCCCCAGCTA |
CTCAGGAGGC |
TGAGGTAGGG |
|
11441 |
GGATTGCTTG |
AGTTCAGGAA |
GTCAAGACTG |
CAGTGAGCTA |
TGATGGTGCC |
ACTGTACTGT |
AGCCTGGGAG |
ACCTGGTTTC |
|
11521 |
AAAGAAACAA |
AAAACAAATC |
AAAACAACAA |
CAAAATGTTG |
CTGCCTCTAC |
CTGTTTTATG |
AATATGTATA |
GAAATGACAT |
|
11601 |
GATGCACTAC |
AACAGTATTA |
ATTCAAGCTC |
TAGATCACAC |
CTCAGAACCC |
CGAATTATAA |
AACAGGTGGC |
CGGGCGCGGT |
|
11681 |
GGCTCACGCC |
TGTAATCCCA |
GCACTTTGGG |
ACACCGAGGT |
GGGCAGATCA |
CGAGGTCAGG |
AGTTCAAGAC |
CAGCCTGTCC |
|
11761 |
AACATCATGA |
AATCTGGTCT |
CTACTAAAAA |
TACAAAAATT |
AGCCAGGTGT |
GGTGGTGCCT |
GTAACCCCAG |
CTACTCGGGA |
|
11841 |
GGCTGAGGCA |
GGAGAATCGC |
TTGAACCTGG |
GAGGCAGAGG |
TTGTAGTGAG |
TCAAGATTGT |
GCCACTGCAC |
TCCAGCCTGG |
|
11921 |
GTGACAGAGC |
AAGACTCCAT |
CTCAATTTAA |
AAAAACAAAC |
AAACAAACAA |
AAAAGAGTGG |
TAACATTGAA |
AATAAATAAG |
|
12001 |
TGTTCTAGTG |
TTTTCTCCCT |
GTACCTGCAG |
TTTGGCACCT |
GCAGCCCCAA |
AAGCTACCGC |
CAGGGGGAGG |
AACAACTGGC |
|
12081 |
TTTAAGTTCA |
GATTTCTCAG |
GTGGGCGAGG |
TGTTCCCACC |
TGGGGCTGGT |
AGGAGGCAGA |
GGGCAGCGGA |
GGCCTCCTTC |
|
12161 |
TTCCAAGAGG |
AGGAGTCCTG |
TGATCCCCAC |
ACTTTGGGAG |
GCCAAAGTGG |
GAGATCGCTT |
GAGCCCATGA |
GTTCAAGACC |
|
12241 |
AGCCTGGGCA |
ACATAGGGAG |
ACTCCGGGCT |
CAGAATAAAC |
CTTCTGCCCA |
GAGAGTCACC |
ATTATTCCAG |
GACGTGGCTC |
|
12321 |
AGATATGATA |
ACAGCTTGCT |
TGAAGCCAAG |
TGCTTTTTGT |
GGTTGATGTC |
ATGACACTCA |
CCCCAAGACC |
CCGCTGGCCC |
|
12401 |
TTGTTTGTCA |
GCTTCTGTCA |
AAGTAAATGT |
TCACTGAGTT |
GATTCCCTAC |
AGCAGGGAGG |
GAGATGATGG |
ACAAGATGGA |
|
12481 |
GACACCATAT |
ACTGAGCATA |
TAAGATGGTC |
ATGGGTCCCT |
GGAACACAGT |
TAAGCTGGAA |
GGGGAGTCAG |
AAACGGTGTA |
|
12561 |
TGTGTTCGGG |
AAAGGGGGTG |
CTGTTGTAAA |
CCCCATCTCT |
ACGAAAAATA |
CAAAAATTAG |
CCAGGCGTGG |
TGGCACATGC |
|
12641 |
CTGTAGTCCT |
AGTTACTCAG |
GAGGCTGAGG |
CATGAGAGTT |
GCTTGAACCT |
GGGAGGTGGA |
GGTTGCCCTG |
AGCTGAGATT |
|
12721 |
GCCCCACTGC |
ACTCCAGCCT |
GGGTGACAGA |
GAGAGACTCC |
GTCTCAAAAA |
AAGAAAAAAA |
ATGACACATC |
ACATACAAAC |
|
12801 |
TATTATATAA |
AGGCCAGGCG |
CGGTGGCTCA |
CGTCTGTAAT |
CCCAGCACTT |
TGGGAGGCCA |
AAGTCAACGT |
CAGGAGTTTA |
|
12881 |
AGACCAGCCT |
GGCCAACATG |
GTGAAACCCT |
GTCTCTACTA |
AAAATACAAA |
AATTAGCTGG |
GTGTGGTGGT |
GCGTGCCTGT |
|
12961 |
AATCCCAGCT |
ACTCAGGATG |
CTGAGGCAGG |
AGAATCACTT |
AAACCTGGGA |
GGCAGAGGTT |
GCAGTGAGCC |
AAGATTCCGC |
|
13041 |
CATTGCACTC |
CAACCTGGGC |
AACAGAGCAA |
GACTCCATCT |
CAAAAAAAAA |
AAAAAAAAAA |
TTAGCCAGGC |
ATGGTAGTGC |
|
13121 |
ACACCTGTAG |
TCCCAGCTAC |
TTGGGAGCTT |
GAGAGAGGAG |
GATTGCTTGA |
GCCCAGGATT |
TCAAGGCTAC |
AGTGAGCTAT |
|
13201 |
GATCAAGCTA |
CTGTACTCCA |
GCCTGGACCA |
GTAGAGCAAA |
ATCCTGTCAA |
AAGAAAAAAA |
AAAAAAAACC |
ATGTTGTCAA |
|
13281 |
AGAATAACAG |
AACGCAGAGG |
TATTTCGGTG |
GTTCTTTTCC |
ACGCTGTTCA |
GTTATTTGCT |
TACTGTTCAG |
TTATTTGCAA |
|
13361 |
ATTGCTCACT |
CACATGTGAG |
GGAGTCAGTG |
GGTAGACTGA |
GTCAAGTACC |
AAAGGCAAAA |
CCAAGATTTA |
GAATAGTGGG |
|
13441 |
CAAGGGAGGA |
AAGTTACAGG |
GCGTGTGGGA |
ACAGTGACAG |
TGACTCTTGT |
CTGTAGGCTT |
TGGAGATAAG |
GTGGTTGCTG |
|
13521 |
GTAGGGAGCC |
CAGAAGGCAG |
TTAGAGCATT |
CTTTCTGCCC |
TTGAAGGGAA |
ACAAACCCTT |
CCCGTTGTTT |
CTGGAGTCCC |
|
13601 |
TGGGAAACGC |
TGTCAGTTTG |
GCCCTGGGCC |
ACACATGCGA |
GCCATCTCTG |
CGTAACCTCT |
GCCAGTGTCC |
TCTGTCAGCA |
|
13681 |
CCTGTTTTAG |
CGGCATTCCT |
CACAGGCAAA |
CAACAGCTGC |
TCCAAAGGGG |
GTGGTTGTTT |
TAAGAAAAAT |
GAGCGCGCAC |
|
13761 |
AAATGTCTGT |
GCAGAAAAGA |
ACATTCCCAC |
CTGTTTAATA |
TGGAAAGTCT |
CACTGTCTTA |
AAAGAAAACA |
GTGGCCGGGC |
|
13841 |
GCAGTGGCTC |
ACACCTGTAA |
TCCCAGCACT |
TTGGGAGGCT |
GAGGTGGGCA |
GATCACGAGG |
TCAGGAGATC |
GAGACCATCC |
|
13921 |
TGACCAACAT |
GGTGAAACCC |
CGTCTCTACT |
AAAAATACAA |
AAATTAGCTA |
GGCATGGTGG |
CGCGTGCCTG |
TGTTCCCAGC |
|
14001 |
TACCTGGAAG |
GCTGAGGCAG |
GAGAATCACT |
TGAACCTGGG |
AGGCGGAGCT |
TGCAGTGAGC |
CAAGATTGCG |
CCACTGCACT |
|
14081 |
CCAGCCTGGC |
AACAGAGCAA |
GACTCCGTCT |
CAAAAAAAAA |
AAAAAAAATA |
GCCACGCATG |
GTGGCGGGTG |
CCTGTAATCT |
|
14161 |
CAGCTACTTG |
AGAGGCGGAG |
GCAGGGAGAA |
TTGCTTGAAC |
TCAGGAGGCA |
GTGGTTGCAG |
TGAGCCGAGA |
TAGCGCCATT |
|
14241 |
GTACTCCAGC |
CTGGGCAACA |
AGAGTGAAAC |
TCCATCTGAA |
AAAAAAAAAA |
AAGAAAAGAA |
AAGAAAAGAA |
AACAGTGGCT |
|
14321 |
GGGCATGGTG |
TCTCACGCCT |
GTAATCCCAA |
CGCTTTGGGA |
GGCTGAAGTG |
GGAGGATCAC |
TTGAGCCCAG |
GAGTTCAAGA |
|
14401 |
CCAGCCCGGG |
CAAATAGGGA |
GACCACCCCA |
CCCCCCATCT |
CTACAAAAAT |
AATTAAAAAG |
ATAAAAAATT |
AGCCGGGCAT |
|
14481 |
GGTGGCATTT |
GCCTGTAGTC |
CCAGCTACTC |
AGTGGGCTGA |
GGTGGGAGGA |
TGGCTTGAGC |
CCAGGAGGTG |
AAGGCTACAG |
|
14561 |
TGAGCTGTGA |
TCAGACCACT |
ACACTCCAGC |
CTGAGTGACA |
GAGCAAGACC |
CTGCCTCCAA |
AAAAAGAAAA |
GAACACAGGT |
|
14641 |
GAATATGCCA |
TCTATGAAAC |
AGGCCATAGT |
AAGAAAGGAC |
CCTGGCTACT |
AAAGGGGAAG |
ATAGTGATTA |
AAGCCAAGGA |
|
14721 |
AGGGCCAGGC |
ATGATGACTC |
ACACTGTAAT |
CCCAGCACAT |
TGGGAGGCTG |
AGGCAGAAGG |
CTCGCTGACC |
AGCCTGGGCA |
|
14801 |
ACATAGTGAG |
ACCCCATCTC |
TACAGAAAAT |
TTTAAAAATC |
AGCCAGATGT |
GGAGGCTGAG |
GTGGGAGGAT |
TGCTTGAGCC |
|
14881 |
CAGGAGTTGG |
AGGCTGCAGT |
GAGCTATGAT |
TGTACCACTG |
CACTATAGCC |
TGGGCGACAG |
AGTGAGACCT |
TGTCTCAAAT |
|
14961 |
ACATAAAAAA |
ACATGGCTAG |
GCACAGTGGC |
TCATGTCTAT |
AATCCCAGCA |
CTTTGGGAGG |
CCGAGGCAAG |
CAAATCACGA |
|
15041 |
GGTCCAGAGT |
TCGAGACCAG |
CCTAGCCAAC |
ATGGTGAAAC |
CCCATCTCTA |
CTAAAAATAC |
AAAAATTAGC |
CAGTCATGGT |
|
15121 |
GGTGCGTGCC |
TGTAATCCCA |
GCTACTTGGG |
AGACTGAGGC |
AGGAAAATCT |
CTTGAACCTG |
GGAGTCAGAG |
GTTGCAGTGA |
|
15201 |
GCCGAGATTG |
TGCCACTGCA |
CTCCAGCCTG |
GGTGACAGAG |
CAAGACTCCA |
TCTCAAAAAA |
CAAACAAACA |
AACAAACAAA |
|
15281 |
CAAACCACAC |
CTAGTAAGCC |
CTCCTGATTC |
ATTTATGTTA |
ATGCTTGCCT |
AGAGCTGCCA |
CATGCAGCTG |
TGCAGGGTGC |
|
15361 |
GCACTGCACA |
AGGATGCCAC |
ATCTGAGGGG |
GCTCCATTAA |
TAACAGAGAC |
ATTGTAAATG |
TATGTTAATT |
TCAGCAATTA |
|
15441 |
ATGACAGGTG |
GAAATAAAGC |
ATCTGGCTCT |
AATAAAACAA |
CATTTTTTTT |
CTGAAAAATG |
AAAGCAAATG |
GCCTGAATTT |
|
15521 |
GCAGAATAAA |
AGCCACACAG |
GCTGTGGAGT |
GGCTGTGGGC |
CTGGCCTCAT |
AGATATTTAG |
GTTTGGGCCC |
CTTTTTTTTT |
|
15601 |
TTTTTTTTTT |
TTAATTTTTT |
GTAGAGACAA |
GCGTCTTGAT |
ATGTTGCTCA |
GGCAGGTCTT |
GAACTCCTGG |
CCTCAAGTGA |
|
15681 |
TCCTCCCACC |
TCAGCCTCCC |
AAAGTGCTGG |
GATTATAGGC |
GTGAGCCGCC |
ATGCCCAGCC |
TGGCCCCTGC |
CTTTAAGCAG |
|
15761 |
CCTTGACTGT |
CACCCTTTAA |
GTGGCACCAT |
TGGGATGAAC |
AGAAGAGTCT |
TCAGATAAAC |
CCTGCCACTT |
GCTTCTCCTC |
|
15841 |
CCTCCCTTCT |
CCACCTGTCC |
CCACCACCTC |
ACTGCTCCTC |
GTGGCCCTCA |
ACTCCCTACT |
GTGCCTTCTG |
GCCTACAAGG |
|
15921 |
GGTGGCTCAC |
TCCTCACCCC |
TCTTCCCTCC |
ATCTCTCCCT |
CTAGAACATA |
GATACCCTGG |
AGCGAATAGC |
CGGGCTGGAA |
|
16001 |
CAGGAGGACT |
TGGTGGAGGC |
GCACGGCACC |
TTCTACACAT |
CACACTGCGT |
CAGCGCCAGC |
TGCCGGCACG |
AATACCCGCT |
|
16081 |
AAGCTGGATG |
AAAGGTGAGG |
CTGGAGGGCA |
TCCTGAGGGC |
AGGCCTCCTC |
TCAGCACCAG |
GAGCAGTGTC |
TCCATGCAGT |
|
16161 |
GGGCACCCAT |
TCTGTCCTGC |
TCAATTCTTT |
GGGGTTTTTT |
TGTTTTGTTT |
GTTTGTTTTT |
GAGACAGAGT |
CTCACTCTGT |
|
16241 |
CGCCCACGCG |
GGGAGTTCAG |
TGGGTGATCA |
TGGCTCACTG |
CAGCCCAACT |
GCCTGATTTC |
CTGTCTTTGG |
CTGTTTTTAA |
|
16321 |
TATATGATAG |
TAGGCCAGGA |
GCAGTGGCTC |
ACACCTGTAA |
TCCTAGCACT |
TTGGGAGGCC |
AAGGCGGGCA |
GATCACCTGA |
|
16401 |
GGTCAGGAGT |
TCAAGACCAG |
CCTGGCTAAC |
ATGGTGAAAC |
CCCGTTTCTA |
CTAGAAATAC |
AAAAAAAAAA |
AAATTAGCCT |
|
16481 |
GGTGTGGTGG |
CATGCGCCTG |
TAATCCCAGC |
TACTCAGGAG |
GCTGAGGCAG |
GAGAATCGCT |
TGAACCTGGG |
AGGCGGAGGC |
|
16561 |
TGCAGTGAGC |
TGAGTTCGCA |
CCATTGCACT |
CCAGCTTGGG |
CAACAAGAGC |
AAAACTCTGT |
CTCAAAAAAA |
AAAAAAAAAA |
|
16641 |
AAAAACAAGA |
AGTCACTTAT |
TCCACTCATG |
GAAAGCCATT |
TCTGACATTC |
TTTATGCTGA |
TTTAACAAAG |
CCTCTGGTGT |
|
16721 |
CCCTGTGAGA |
TAAGGACAGC |
TGCAGCATTT |
GCAGAAGGGC |
CTCTGGAGTG |
TGGCTGTTCT |
GATAAAATGC |
CAGCTGAGTG |
|
16801 |
CCCCTGGGCT |
GAGGATTCCT |
GAATAGCCCA |
ACTGCAAGCA |
GCTGGGGGCA |
GTGTACAATT |
CACATTACCC |
CCATTATGTG |
|
16881 |
TCATTGACAG |
CAGCGTCACA |
GGCAGCACCC |
ACGGTGTCAT |
GCTGTCCATG |
CAGAAATATT |
TTAAAGAAAA |
TTACCGACTA |
|
16961 |
CTGACATTGA |
AACAATGCTT |
TATAAATGTG |
TGCTGAATGA |
ATGAATGGAC |
AGTTGAGCAA |
ATGACTTAGA |
ATTCAGTGGG |
|
17041 |
TTGCAAGTGA |
CAGAAATGCT |
TTCTTTCTTT |
CTTTTTTTTT |
TTTTTGAGAT |
GGAGTCTTGC |
TCTGTCACCC |
AGGCTGGAGT |
|
17121 |
GCAGTGGTGC |
AATCTCGGCT |
CACTGCAACC |
TCCGCCTCCC |
GGGTTCAAGC |
AATTCTCCCT |
GCCTCGGCCT |
CCCAAGTAGC |
|
17201 |
TGGGATTACA |
GGCACGTGCT |
ACAACCCCTG |
GCTAATTTTT |
ATATTTTTAG |
TAGAGACGGG |
GTTTCACCAC |
GTTGGCCAGG |
|
17281 |
CTGGTCTCAA |
ACTCCTGACC |
TCAAACGATC |
CACTCGCCTC |
AGCCTCCCAA |
AGTGCTGGGA |
TTACAGGCGT |
GAGCCACCAC |
|
17361 |
ACCCGGCCAG |
AAATGCTTTC |
AAGCTTCCTA |
AATCAATAAG |
AAATAAGGCC |
AGGCACAGTG |
GCTCATGCCT |
GTAATCCCAA |
|
17441 |
CACTTTTGGA |
CGTCGAGGTG |
GGTGGATCAC |
TTGAGCCCAG |
GAGTTTGAGA |
ACAGCCTGGG |
CAACATAGGG |
AGATCCCATC |
|
17521 |
TCTAAAAAAA |
ATAAAATGTA |
GCCAGGTGCG |
ATGGTGGATG |
CCTGTGAGCC |
CAGCTACTCG |
GGAGGCTAAG |
GCAGGAGGAT |
|
17601 |
CACTTGAGCC |
TGGGAAGTCG |
GTGGTGCAGT |
AAGCTATGAT |
CACACCACTG |
CACTCAACCA |
TGATTGCACC |
ACCACACTCC |
|
17681 |
AGCCTGGGCA |
ACAGAGTGAG |
AACCTGTCTC |
AAAAAAACAA |
ACAAACCAAT |
AAGGCCGGGC |
GCAGTGGCTC |
ACACCTGTAA |
|
17761 |
TTGCAGCTCT |
TTGAGAAGCC |
AAAGTGGGCA |
GATTTGCTTG |
AGCCCAGGAG |
TTTGAGACCA |
GCCTGGGCAA |
CATGGCGAAA |
|
17841 |
CCCTGTCTCT |
ACAAAAAATA |
CAAAATTTAG |
CCGGGCGTGC |
TGGCATGCAC |
CTGTAATCCC |
AGCTACTCAG |
GAGGCTGAGG |
|
17921 |
CAGGAGGATC |
ACTTGAAGCT |
GGGAGGTTGA |
GGCTACAGTA |
AGCCATGATC |
GTGCCACTGC |
ATTCCAGCCC |
GGGCAACAGA |
|
18001 |
GTGAGACCTT |
ATCTCAAAAA |
AAAAAAGAAA |
GAAAAAAACA |
AAAAAAATGC |
AACAACAAGA |
AGAGAGGTCT |
TTTCTGAGCA |
|
18081 |
GAGTGGACAC |
CTCAGGAGAC |
ACCCATCACA |
CTCCAAGTGA |
TGGAGGTGTG |
TTCATGTTAA |
CAGTGGAAGA |
GGGGTGGGGG |
|
18161 |
TGCTGCACCT |
CCAGACTCCG |
GCCCAGATCC |
TCTTACTGCC |
TTCTCTTTCT |
TCCCCTTCCC |
CATACCCAGA |
GAAGATCTTC |
|
18241 |
TCTGAGGTGA |
CGCCCAAGTG |
TGAAGACTGT |
CAGAGCCTGG |
TGAAGCCTGG |
TGAGCCTCTG |
GCCAGGGACC |
TGCCCAGGTG |
|
18321 |
GATTTGGGTG |
GGGGTCCCCT |
CCTCCCCCTG |
ACCCCCTCCC |
AAAGGCCACA |
CCCGCACACA |
TCTGGCCACC |
TCTGTCTCTC |
|
18401 |
TGAACAGTGC |
CCCAGATCCA |
TCCTGGGGAG |
AATGGGGTCT |
GTGCCCCTGG |
CCGGTCCCCA |
CTGCTCCCAA |
CTCCCACTGT |
|
18481 |
GGCCTCCGGG |
TCTGCCATTG |
CTCCCACCTG |
TCCTCTCTGC |
CTCCCCATGT |
CACTGTCTCT |
GTCCGTCCAT |
CTGTCTCCAC |
|
18561 |
CTCAGATATC |
GTCTTTTTTG |
GTGAGAGCCT |
CCCAGCGCGT |
TTCTTCTCCT |
GTATGCAGTC |
AGTAAGTGGC |
CCCCCAGCCT |
|
18641 |
CCCCGCATCC |
CCAACCGCCG |
CCTCCACCTG |
TGCTGGGCCC |
CATGGGGGCA |
GCCTGGGCCC |
TGCCTCAGGA |
AAGGTCACCT |
|
18721 |
CCCCAGCTAT |
GGGGGGCGGC |
AGGGAGGTTT |
GCTGCTGGGG |
GCGGGGGAGG |
GAGCGGTGGC |
GCAGCCTGGG |
CGGAGGCTCC |
|
18801 |
CAAGCTCACG |
CCCCTCCCCG |
CAGGACTTCC |
TGAAGGTGGA |
CCTCCTCCTG |
GTCATGGGTA |
CCTCCTTGCA |
GGTGCAGCCC |
|
18881 |
TTTGCCTCCC |
TCATCAGCAA |
GTAGGTTGGG |
GGCTGTGGCT |
GGGAGGACGG |
CTGGGCACCC |
AGGGCCAGGA |
CAGACCCTGA |
|
18961 |
CCCCTTAGCT |
CCCCCTCCCC |
ACAGGGCACC |
CCTCTCCACC |
CCTCGCCTGC |
TCATCAACAA |
GGAGAAAGCT |
GGCCAGGTAA |
|
19041 |
GAGCCCTTCT |
TCAAGCCCCC |
GTCGTCACAG |
GCTCCCCCTT |
CCCTCTCACC |
CTTTTCCTCA |
GAGGGAACCC |
CCACTGTGGA |
|
19121 |
ACCCCAGCAC |
TTTGCATTCC |
TCAGCTCAGA |
ACCTGGGGCT |
CTAGAATCCA |
GAGGGGTCGG |
GTTCCAGGCC |
TCTGGGACAT |
|
19201 |
TCACTGCCCT |
TTTGAGCAAG |
TGATAGAATT |
CCAACTCAAA |
CCAGCTGAAG |
CCAGATAGGA |
AGGCCGGGCT |
TCCAGGGACT |
|
19281 |
GAGGAGGTGG |
GAGGGGGTGC |
AGGGGTCAGG |
AGAGACAGTG |
CGGGGGGCGG |
GGTTGGGTCC |
ACGCTCTGGG |
TCTCTCAGGT |
|
19361 |
CTGTTTTTCC |
TGGGCAGCCT |
CACTCTAGGG |
CAGGTGCTCC |
CTCCTAGGTG |
TTCCCCTCAG |
GGGAAGTAGG |
CAGGGTCACC |
|
19441 |
GGGCAAGCAG |
CGCACGCTGT |
GGGCAGACAC |
TGTCCCAAGT |
CTTAGCCTGC |
GTGAACTCAC |
TGGCGCCACA |
ACCCCATCGC |
|
19521 |
GGTTTTGTGA |
TCACCCCTAT |
TCTACAGGAA |
ACTAAGACAC |
AGAGAGGACA |
AGTCACTTGA |
CCAAAGTCAC |
TGAGCTGGCT |
|
19601 |
GGGCGCAATG |
GCTCACGCCT |
GTAATTCCAG |
CACTTTGGGA |
GGCCGAGGCG |
GGTGGATCAC |
CTGAGGTCAG |
GAGTTCGAGA |
|
19681 |
CCAGCCTGAC |
CAACATGGTG |
AAACCCCGTC |
TCTACTAATA |
ATACAAAATT |
AGCCGGGCAT |
GGTGCTGGGC |
ACCTGTCATC |
|
19761 |
CAGGCTACTC |
GGGAGGTTGA |
GGCGGGAGAA |
TCACTTGAAC |
CCAGGAGGTG |
GAGGTTGCAG |
TGAGCCGAGA |
TCACATCATT |
|
19841 |
GCACTCCAGC |
CTGGGCAACA |
AGAGTGAAAC |
TTTGTCTCAA |
AAAAAACCAA |
AAAAACAACA |
ACAAAAAAAA |
AACAAAGTCA |
|
19921 |
CAGAGCTAGG |
ATACAAACCC |
AGGCCACCTG |
GCTCCAGGGT |
CTGTGCTCTT |
AGCTCTCCCT |
TCCCTGCTCC |
TGCCCCTGAC |
|
20001 |
CCACCCCCTC |
CCTGACAGTC |
GGACCCTTTC |
CTGGGGATGA |
TTATGGGCCT |
CGGAGGAGGC |
ATGGACTTTG |
ACTCCAAGAA |
|
20081 |
GGCCTACAGG |
TGAGGCCCCG |
CCGGGGGTTG |
GGGCAGCCTG |
GAAGGGACAG |
GGTGAGGTGG |
GAGCGGGGGC |
ACGAAGGCAG |
|
20161 |
ATGAGAGGAG |
CAGGCAGGGG |
CGAGCCCGCC |
TGGGAACTCT |
GATCTCCTGC |
TGCACCGCAG |
GGACGTGGCC |
TGGCTGGGTG |
|
20241 |
AATGCGACCA |
GGGCTGCCTG |
GCCCTTGCTG |
AGCTCCTTGG |
ATGGAAGGTG |
AGGAGCTGAG |
CAACCCCAGC |
CTGTCCTGAG |
|
20321 |
CCCCATCCCT |
GGACCCTCTC |
CCCACCCCAT |
GGGTCCTCTG |
ACCCCATGAT |
GCACAGTGAC |
CTTTGACTTC |
TGTGACCTTT |
|
20401 |
GCTCCTGCAG |
AAGGAGCTGG |
AGGACCTTGT |
CCGGAGGGAG |
CACGCCAGCA |
TAGATGCCCA |
GTCGGGGGCG |
GGGGTCCCCA |
|
20481 |
ACCCCAGCAC |
TTCAGCTTCC |
CCCAAGAAGT |
CCCCGCCACC |
TGCCAAGGAC |
GAGGCCAGGA |
CAACAGAGAG |
GGAGAAACCC |
|
20561 |
CAGTGACAGC |
TGCATCTCCC |
AGGCGGGATG |
CCGAGCTCCT |
CAGGGACAGC |
TGAGCCCCAA |
CCGGGCCTGG |
CCCCCTCTTA |
|
20641 |
ACCAGCAGTT |
CTTGTCTGGG |
GAGCTCAGAA |
CATCCCCCAA |
TCTCTTACAG |
CTCCCTCCCC |
AAAACTGGGG |
TCCCAGCAAC |
|
20721 |
CCTGGCCCCC |
AACCCCAGCA |
AATCTCTAAC |
ACCTCCTAGA |
GGCCAAGGCT |
TAAACAGGCA |
TCTCTACCAG |
CCCCACTGTC |
|
20801 |
TCTAACCACT |
CCTGGGCTAA |
GGAGTAACCT |
CCCTCATCTC |
TAACTGCCCC |
CACGGGGCCA |
GGGCTACCCC |
AGAACTTTTA |
|
20881 |
ACTCTTCCAG |
GACAGGGAGC |
TTCGGGCCCC |
CACTCTGTCT |
CCTGCCCCCG |
GGGGCCTGTG |
GCTAAGTAAA |
CCATACCTAA |
|
20961 |
CCTACCCCAG |
TGTGGGTGTG |
GGCCTCTGAA |
TATAACCCAC |
ACCCAGCGTA |
GGGGGAGTCT |
GAGCCGGGAG |
GGCTCCCGAG |
|
21041 |
TCTCTGCCTT |
CAGCTCCCAA |
AGTGGGTGGT |
GGGCCCCCTT |
CACGTGGGAC |
CCACTTCCCA |
TGCTGGATGG |
GCAGAAGACA |
|
21121 |
TTGCTTATTG |
GAGACAAATT |
AAAAACAAAA |
ACAACTAACA |
AT |
|
|
|
|
|
|
|
|
|
|
|
|
>ref|Gene_ID:22933|SIRT2|NC_000019.9:39369199...39390360 (-)
TGTTGTACGAAAGCGCGTCTGCGGCCGCAATGTCTGCTGAGAGTTGTAGTTCTGTGCCCTATCACGGCCACTCCCATTTC
TGGTGCCGTCACGGGACAGAGCAGTCGGTGACAGGACAGAGCAGTCGGTGACGGGACACAGTGGTTGGTGACGGGACAGA
GCGGTCGGTGACAGCCTCAAGGGCTTCAGCACCGCGCCCATGGCAGAGCCAGACCGTGAGTCGGGGATCCGGGTAGGAGG
GTCGGGCCGCGCCGGGGCCTGGCTGAATGCTGCAGGCCCCGGGGCCCAAGGGTGGCCGCGGTGGGGCGGGAAGTAGGGAG
CGCTTCGGGGAGTGGGATTCTGAGGGCTGTTGCTTAGCGATCTGTATCGCTAGGCTGGTGGGTTTCTGGGTCGCAGTGTG
TTCAGGGTTCGTTTACCACATCCACTTGCCAAGTTGCCAATGATCGCGTGTTTCTCGCACCTTGGTTGCTAAGGTCCCTC
GCTGCAAAGAACATAAGTTGCCCCGGTCCCGCTTGCTATGGGTACCTGATTGTTAGAGGCAACCAGAGGATGCTGAGGGA
CCCCTGCTGACCCCTCCTATGGCTTCCCCTTGTTCCGCGCCTCTCCTAAACCTACCGCCTCCACTGCACCACTGCACCTC
CCTCCTAAACCTGCCTCCCAGCCAAAGCGTCTCTTCCCTTCTCTTTTCCTTTCTAAACTTCCCTCTGCCTTGTAAATCTA
ACCCTCCCCGCACACACACTCACACACTGTCGTGTCCTTCCTAACTCCTCCTGAGTGTTCCTTCATGCCCTGAATCCCCT
AGGTAGGAGGAGGAGGATCGCTTGAGCCCAGGAATTTGAGGCTGCAGTGAGCTATGATCGCACTATTGCACTCCAACCTG
GGTGACATGAGCGAGACCCTTTCTCTAAAAAGTAAAAAAGAAAGAAAGTAAGTCAGGGCCAGAAACAATGGCTCATGCTT
GTAATCCCAGTACTTTGGGAGGCCAAGGTGGTTGGATCGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAAAAGCCCC
TACTTTCTCCCTGTCCCCCTAAATCTTCCTCTCCAGCCTCTCTGCCCCTCACTAATCACCTCTCCCGGCATCACTTTGCA
TGTAGATAAGATCTTTTCTCCGTCCCCTCCCTCCCTCTGCTCCATTTTTACCACCATCCCATCCCAGTGTAACTAGGTTG
GTGGGTGTTCTTGCCCCCTCACTGACCATTTGAACCCCTTTATTCCCCCCTTAATCGTTCTCCCCACTGTAACCACCTCT
GCTCCCCTCCCCCAGCCTCTCACCCTCTGGAGACCCAGGCAGGGAAGGTGCAGGAGGCTCAGGTGAGATGGGGGAAAGGG
TGGAGGGGAGGAGAGAGACGGACTTGTTCCACATCCCACACTGGGGGGAGGTGGCAAAGGGGAAACAGTCACCCCAGGGC
CCTCGGCTCATTGCCCCAATCCCTCACACCACCCAGTGCAGCTTTCTGGGGAAAGGCAGATTCTGGGGATTGTCAGAGAA
GAGTTTCCAGCCTCAAGTCCAGGCCTGTCCTCCCAAACTTTCCTTCTTCCTTGCCACTGCCTGCCATCCCTTCTGAACCA
CATTTGTCCTGGGACTGGAAGAGACAGGTATCCCATTTGGTCTTGGAACGCACAGATCTCGTGGACAAGTGATGGGAAAA
AATGATCTCACAGCGTGATGACGAAAGTAACTCAGGGGGCCAGATGCAGTGGCTTATGCCTGTAATTCCAATAACTCAGG
AGACTGAGGCGCGAGGATCGCTTGAGCCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCATCACTGCACTCCAGCCGG
GGTGAAAGAGCAAGACCCTTTCTCTAAAAAGTAAAAAAGAAAGAAAGTAACTCAGGGCCAGACACAGTGGCTCATGCTTG
TAATCCCAGTACTTTGGGAGGCTGAGGTAGGAGGATCGCTTGAGCCCAGGAGTTCCAGACCAGTCTTGGCAACATAGGGA
GGCCCCCACCTCTACAAAATATTTAAAAATTAGCCATGTGTAGTGGTGCATGCCTGCATTGCCAGCTACTCAGGAGGCTG
AGTTGGGGGAGGATTGCTTAAGCCCAGGAGGTTAAGGCCGTAGTGTGCCTTGACTGTGCCACTGCACCCCAACCGGGGCG
ACAGAGCAAAACACGGTCTCAAAAAAAAAAAAAGGAAGAAAAGTAAAGAAACTCAGGGTACTGTGGGAGCACAGAGAAAA
TTTTCTGGGTCAAAGAAGATTCTAGCCAGGCCATTCCCTGGAGGAATCCACAGGCTGGTCTAGCTGTCAGACCAAGATAC
AGACACAGCATAAGTGAAGAGTGACTTAGAATTTTCTTAGACAAGGTGAGAAATGGTGATCCACACAACAGGTATCGCTT
GTGCAAAGACCTGGGGGGCATGAAGGGGTGTGATGTGTTCCATAATTGGGTGGCTGGTGGTGGTCAGCTTGTTATAGTCG
TGGTTAGCATTTACTGACGGCTTACTAAAGCTGGGCCCACTGTTTAGTGCCAAACGTGCCTCATCTCAATTTCATCTTCC
TGGCATCCCTGTGAAGAGAAACGCCTATCACGGCCATTTTACAGATGCAGAATCTGAGGCAGAGTTGTTAAGTCACTTAT
CCCCCGTCCCTCGGCTACAGGAGCAGGGAAGGGTTTGAGTCCCCCAGCACTGGGCACGCCACCTGTCAGAGGCTGCCAGG
AGAGGTGGACAGGCAGTCTCATAGGAGCTTGAAGGCCCCCGTCAGCACCTCCGGCTCTCCCTTAGGCCAAGCTGCAGACA
CATGCTGGGCACAGGCCTTCCACACAGCCTCACTGTGTACAGCCTGAAAGAGTGCCAGCCCACCCACACCCCTGAGATTG
CCTTTCAGACGTGGGGTGGTGCAGAAGCGGGCATCAGAATACCTCACAAATGCACAGTGGAGCTTTGCTAAGGATATAAG
AGCCTCCTGTTAGGCTGTGGCAACTCACTCGCCTGGCTCCCAAAGCACGACCACTGTCAGAGAAAAAGGTTGAATGTTAA
AAAGGATCCTCAGTCCCAAAGAGAGAGAGGCGAGGATGTAAAATGCAGCATTGTCCGTCACAGGGCAAAACTGGAAACAG
TCCAAATGGCTGTCAGTGGATGGGTTAAATGAACTATGGTTCATCCATACAATCCAATACTATGTAGCTGCTCTGAAAAA
CGAGGTGAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCAGGGGGATCACTTGAGCCCAGGAGT
TTTGAGACCAGCCTGGGCAACATAGCAAGATGCCGTCTCTTTTTTAAAAAATTATTTTTTAAATTAGGTGGGTCTGTAGC
ATATTGTTCTGCCGAAAACTCAAGATGTTGTATTGTACTATGACCTATTTCTGTAAAAAATATTAGTTTTATGCAGAGAA
AACTGGAGTAATTTCCATTAAGCTTAGCTAACAGTGGTTATCTTTATAAGGGTGGGCTTGGGCAATTACAAGGTGAGTGC
CGCAAGTTATATGTTGTTGAAGTATACATGAGTATAATCAAGGTTTTTGCAGAGGTTGTCCAATCTCTCTTTCTCTCTGT
CTCTCTCTCTCTCTCATTCTCACTCTCTCTTTCTCTCTCTCTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCT
GGAGTGCAGTGGGGTGATCTCGCTGACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAAT
AGCTGGGACTACAGACACGTGCCACCATGCCTGGCTAATTTTTTGTATTTTTATTAGACACGGGGTTTCATCATGTTGGC
CAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACC
GTGCTCAGCCTTTCTCTCTCTTTTTAAATAGAGACAGAGTCTCACTGTGTTGCCCAGGCTGGTCTTGAACTCCTGGCATC
AAGCAACCTTCCTGCCTCAGCCTCCCAAAGTGGTGGGATTACAGGCATGAGCCACCACGCCCAGCCGGAGTTGCACAGTC
TTAAAAAGCAATTTTTTAAATTGTCGTATGTTCGGAAGGGAGGGTCTTATTCAAAAAGACTTGGACGCAGAGCAGTGAGT
ATCCGGGGAAGGGAGTTGTCTGAGGTGGTGGCTTGGTCAGAACTGCATTTTGGTGAAATCCATTGCAGGGCCCAGCCGTG
GTCCAGCCTGAAGCAGGCATTCATTCCAAGGTAGAGGAGCTCCTGGAGCTCCTGCCAGGAGCCAGACCCTGTTCTCAGTG
CTGGGCACCCAGACAAAGTCCCTGCCCTTGTGGACATCCTGGCAATTCCATAGATGTCTGGGAAGACTGCAGAAGCCAGA
GAGAAGGGCCTTTGAAGTGGAGAGGGGCGAGCTGACCCAGACAGCCTCACATGCAGGGCAGCAGGGTGGATGGGAGGTGG
AGACTGAGGCTGGGAGGCTGGGGGAGGAGGCTGGGGCAGGACCCCCGGAGGAGAGGACAGGCTGGACCAGGTGGAGCGCC
GGGGAGGGAAAGGGGGTTGGTGGACAGACCCTTAGGAGGCTCAGCGTACATGCTCTGGAGCTGAAGGGCTGTGGCAGGAG
GGCGAGGAGGGAGGCGGGGGCAGGAAACATCTGGCTGATGGGGGGGACAGTACGATCGCATTGAGATGAGGCCTGGGAGG
AGGATGGGCTTGGAGGAGATGCCAGGGTCCATTTGGGACATAGTAGGAGTGAGAGGCTGGGGGGCACCTAGGGCAAGGTG
TCCAGGAAGCCAGGGAACCCCGGATCTGAGGGCAGAGAGATGGTATCATGAGTGACGAGGCAGAGGTCATTGGCATGGAT
GAGACAGGTAACCCCAGGAAAGTGGAAAGAGAAAGCAGAGAGGCCCTGGACAGAGTCCCAGAGACCTGCCAGTCTGGAGC
TGGGCTGAGGGGAGGCTTCGAGGAAGGAGACAGAGGTTGCTGGAGAGGTGGGCAGAGTGTCTGAGGCCTCGAGCAGGGGG
CACATAGGTCCTTGAAGTGAGGGCCAAGGCTTTGCATTGGAATCATTCCCAGAGTGACTTGGGACATTATTCAGAGGCCC
CCAGGGCTGCTGGGAAGGGACAGCAGGCCCACGCTCCAGGGGACCCGGGAACGAAGGGAAGACCCCAGGCTGTGATAATA
ACAGCAACAGCCAGCGCTTACCAAGCACTTCCCCCGCCCCTGGTGCTGCGCCCAGCACCCAAGCTCCCTTTCCAAGGTGA
GGGACACCAAGACTTAGAAAATCAAAGTCACGACCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCG
AGGCAGGAGACTTGCTTGAGCCCAGGAGTTCAAGACCACCCTGGGCAACAGAGGAAGACCTCGTCTCTACAAAGCAAACA
AACAAACAAACAAAAAATGAGCCTGGCATGGTGGCACGTGCCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGAT
CCCTTGAGCTTGGGAGGTTGAGGCTGCAGCAAGCTGTGACTGCACCAGTGCACTCCAGCCTGGGCAACAGAGCGAGACAC
TGTCTCAAAAAAGAAAAGCAAAGCAAAGCCACTCACATGAGGTCTTGCTCCTGGGGACGGGCATGGCCAGGACTCCAACC
CCGGCAGCCTGTCCCAGAGCCCTGGAGCTAGCCCCAGTGCAGTCTCTCCACCACCCCGCACTTCCTCAGGCCACCTTCCT
GCCACAGCCTTTTCCCCAAACCTGGTATCACCCCCTCTCCTCCCTCCCTAATCCCACCTCTCGGGCCTGGCCACTCCACC
CCACCCCTTCCAGGACTCAGATTCAGACTCTGAGGGAGGAGCCGCTGGTGGAGAAGCAGACAGTGAGTATCTTCCTGGAG
GGACAGGGAGCAGGGTTCTGGGGGGCGGGGGGATTTCAGGGCAGGGGTGTGGGTGATACCTCCTCAACTCCATCAGGAGT
GACATCCAAAGTATGTAGCAGTGGGTTGGGTACCAGTGCCAGAGCAGGCTCCTGGAGGCCGCTGGCTGGGCCGGGCCTTG
TGCCTTTAGATGTGGGGAGGCCGGGAACCCCAGGGCTGGGGCCAGGGTGCCGGAGACATCCATGCCCCTGGCTGAATGCC
CGTCCTGCCGCTGTCTCTCTTCTTTCCGGTCAGTGGACTTCCTGCGGAACTTATTCTCCCAGACGCTCAGCCTGGGCAGC
CAGAAGGAGCGTCTGCTGGACGAGCTGACCTTGGAAGGGGTGGCCCGGTACATGCAGAGCGAACGCTGTGAGTCCCCTGT
CAGGATTGGGCCACTTTGCCTGGCTCCTGGCCCCAAGTGACCTCCCATCCCCAGCCACTTGAACCATTTATTGAAACCTT
TTCTTTATAAGTAGCAAGAAACCCAGCTGGAACTGGCTTAAGCCAAAAAGGAGTGTGTTGGCTCTAATCCAGCTTGAAGC
ACGGCTGGGTCCAGGTGCTTCCACTTTGTTAAAAATCATAACTCTCTCTGATGCTGCTTTTCTTGTTTTGGGGTAAAGGT
AACTCCTGGCAGCTGCAAATGCAGGTTCCACTAGCCTAGGAGCTGCCACCGAGAGAGCACCTTTTCCCAGTAGTTCAAAC
CAAACAGCAGAGATTGGCTCCCATTGGTCCCGGTTGAGTCAAATGCCTGCCCCCATGCCTCTGATTGGCCAGACCTGGGT
CGCTTCTCCATTGCTGAGTGAATTACTGCACTCTGATTGACCAGGCCTGTTTCATAAAATGAGGATAATGATTATAGTAT
CTAACTCATAAGGTTATTGGCGGGGCTAAATAAATTAATATAGGACCAGGGGCAGTGGCTCATGTATGTAATCTCAGCAC
TTTGGGAGGCCATCGTGGGAGGATCACTCAACGCCAGGCGTTCAAGACCAGCCTGGGCAACATAGTGAGACCCCCCCGCC
ATCTCTACAAGAAAAAAAAAAATAGTCAGATATGGGGGCGTTGCCTGTAGTCTCAGTTACTCAGGAGGCTGAGAAGGGAG
GATTGTTTGAGCCCAGGAATTGGAGGCTGCAGTGAGCTATGATGGCACCACTGCACTGCAGCCTGGGCAACACAGTGAGA
CTCTGACTCTAAAAAAAAATAAAGTAATAAAATTTAAAAGATAAATAAAAATGCAAATGCTTAGAGCAGGGCCTGGAACA
TAGCGAGAGCTGTGGCAGGGTGTGCCGTGGTTATTACTACAGGAGGCTTATTTCAGATGTGGTGGATAGGTGTCCACTTA
CTGAGTCAGCATGAAATTTATATTTCTTTTTCTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGT
GCAGTGGCACAATCTCAGCTCACTGCAACCTCCACCTCCCGGGTTCCAGCAATTCTCCTGCCTCAGCCTCCCGAGTGGCT
GGGATTACAGACGCACACCACCACGACTGGCTAATTTTTTGTATTTTAGTAGAGACAGGGTTTCACCATGTTGCCCAGGC
TGGTCTTGAACACCTGAGCTCAGGCAATCCACCCTCCTCGGCCTCCCAAAGTGCTAGGATTAGAGGCATGAACCACCCGT
CCCGGCCTGAAATTTATATTTCTTGCCACAAGTTGAGGTCACCAAAGTCTGAGAAACCAGGCCCTTGGCAGTCCTCAACT
AGAACAATCGACCCTTTGTGGTTCCTGAGCAGCCTTTTGTTGAGGACATCTTCTCCTGTGTCCCTGTCCTCCAGCTGCCA
CTGTCTCCCTCCTCAGGCAGCCAGGCCTGCTGCCCTGAGCCTCCCTCTCCTGCGGCAGGCGAGCAGCTGTCTGCAGCCAT
CTTTTAGCCTGGGCAGGCCCCAAAGACAACACAGGCAGTGGCTACAAAGCATTTGTTCCTTGTGTCCTCCTGCACCTGGA
TTCTGGGGTAATTGGCTCATGAGGGTGCCCAGGAGGAGATAGTAATGAAAAATAACAATTAGTTGAGGCCGGGAGTGGTG
GTTCAGGCCTATAATCCCACCATTTTGGGAGGCTGAAAGCAGGAGGATCGCTTGAGGCCAGTAGGTCAAGACTAGCCTGG
GCAATAAGCGAGACCCCCTCTCTGCAAAAATTTAAAGGTGAGGCTCCAACCCTCACCTCACTGCTCTAAAAATTTATTAT
TATTATTATTTTGAGACAGAGTCTCACTCTGTTACCCAGGCTGGAGTGCAGTGGCGCTATCATGGCTCACTGCAACCTCT
GCCTCCCGGGTTCAAGCGATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCGTGCCACCACGCCCGGCTA
ATTTTTGTACTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCC
CCCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACCGGGCCCGGCCCTAAAAATTTCTTTTTAACCACTTAA
TTGAGGCTTCACTATTTGCCAGGCACTGGGCTCAGCACTTTACAAGTGCCCTATTATTTGATATTCACATTATACCTGTA
AGATCATTATGGAAGTGATCTGAACAGAGGAGGAAAAGGAGGCACAAAAAGGTCACGACTCAGTGTAGGGTCAAACAGTT
GCCAAGTGGCAGAGCCAGGATTTGACCCCAGGTCCCCTGAATCCAGACCACATGTAGCCACCACTGGATTCAACCAGGCC
TGGCCTGATGGCATCTCAGAGCTGAAGCTCAGGGCTGAAGCTGTGGCAGGCTTTGTGCTCTGTTCACCTTTGCTGTCCTC
CCTTGGACAGGGCATCCCAGAGGCATCTGATCCACAGCATATCACACTTGTGCCTGTCTATCAGCTGATGGGCAGATGCC
AGGGTACTATGGCCTGGTGGCTACTCACCAGCCACCAGCTAGCTATTTCTGCTCAGCCCAGGGTTCTTATCCTAAAGTGG
CCTTTTCTCAAGTCCAAGTTGGTGTGATTTCCAACAGTGGATTCTCTTTTTTTTTTTTTTTTCCTTTTTTTGAGATGGAG
TCTCGCTCTGTCACCCAGGCTAGAGTGCAATGGCATGATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGATT
CTCCTGCCTCAGCCTCCCAAGTAGCTGAGATTACAGGCACGTGCCACCACGCCTGGCTAATTTTGTATTTTCAGTAGAGA
TGAGGTTTTGCCATGTTGGCCAGGCTGGGCTCAAACTCTTGACCTCAGATGACCCGCCTGCCTCAGCCTCCCAAAGTTCT
GGGATTACAGGCATGAGCCACTGCACCCAGCCCAACACTGGATTCTTTATCCGCTGGCTGGCTCTTCCGCAGTTGATTGT
GTGACTTCTTCCCCTATCTGAGCCCCAGTTTTCTCATTTATAAAATGGGGATGTTAACACCATCCCCGTCTAGATGATTG
GAAGGCCCGTCATGCATCTGAGATGCTTGCCCCAGGGCCTGGCATGGAGTAAACGATGTCAGGGGCTGTGATGGGTGGTG
CTATCGTAGGGACTGAGCAAACGGTGTCATATGGTGCATAAGTTCCTCTCCTCCAGGTCGCAGAGTCATCTGTTTGGTGG
GAGCTGGAATCTCCACATGTAAGTAACCCTTCTCCCCCAGCAGCTACCCCCAGGAACTGGGGAGTCCCTCCCAAGGGCTG
GGGAGGAGCCCTATCTGAGCCCTGTCCTGGGAGGGTTAGTATGGTATAGACCAACTGCTCCCTGACCCCCCTTTCCTAGC
CGCAGGCATCCCCGACTTTCGCTCTCCATCCACCGGCCTCTATGACAACCTAGAGAAGTACCATCTTCCCTACCCAGAGG
CCATCTTTGAGATCAGCTATTTCAAGGTTTGTGCTCCCCCAGGAAGGGGCGTCTGTGAGGGGTGGGGATGGGGTCACCTG
GCTCCAACCCTCACGCTACCTGGGGCATCTGGCCCTCTGGCTGTCTCTCCTACAGAAACATCCGGAACCCTTCTTCGCCC
TCGCCAAGGAACTCTATCCTGGGCAGTTCAAGGTGAGATCTTTGTTTTGCAGGGGGCGAAACAGGAAGGGTTGGGGGAGG
GCACGCATGAGAAGCCCCGCCAAGGCCCTGCAGACAAATATTATGTAGCCATTAAGTACATGGGTGCTGGGCCCAGACTG
CCTCGGTTCAAGTCCTGGTTCCTCGTGTCTTCATCTTACGACCTTGAGCCTCCGATTTGCCTCCTGTGAAGTGAAGCTAA
TGGTACTGTCTGAAGAGGGCTGCTGCGAGGCTTAGCTGACTAATGATGCCGTTGAGAGCCCGGGACCCTGCAGCCGGGCT
GCCTGGGTGTGAATCTCAGCTCTGCAGCTTACCCACCGTGTGACTTTGGCAACACAATCCCCTTCCCTGTCCTTCAGTTT
CCTCATCTGTGATCTGGGGATAGCAGTGGTCTCTCCCCGACGCGGCTGCTGTGACGGTTCCCTGGGGGTAAAACAGTCAC
AGTGCCTAGAACAGTTCCTGGCATGCGGCAGTGGCCTGTGGCTGTTCCCTGCAGTCGTCAGCAGTGCTGTCGCTCTTCCC
TGCAGCCAACCATCTGTCACTACTTCATGCGCCTGCTGAAGGACAAGGGGCTACTCCTGCGCTGCTACACGCAGGTAGGC
GGATGCGAGCATCCTGGGAGGAGGATGGGCGGGTGGAACGGGCATGGTGTCCTCAGCAGAGGAGCAGAGCTGCGTGCCCA
AGAGCTCAGGCGGGGACTCCAGCAATGCGGGGCCAGGGCTTGGCCTACTGCCTCCTTGCTGCATGACCTGCCGTGAGTCA
CGTCTTCTCTGCCTCAGTTTCCCCTTCCGTCAAACAGGGGCCAGAAAAGGTTTGCCCTCTCAGGTCTGCCCTCTCAGGTC
TGCAGTGCGGTGGCAGTGACCTCCTCTCAGGGCCATCCCATGTGTGATGTGGAAGGAGCCTATGGCTGAAGGGACTCTGT
GTGCACTATAGGCACCCCAGATTTCACATTGGTTATGAGCGAGTTTCCAAAGTGACTTCATCTAACAAAATCCATACACT
ATGACACGTGTCCAACAAGTAGATGTTGTGCCTTAAGGAAGGGGCACCTTTTTATAGTTTTTTGTGCTTTGCCCAATTAT
AAACATGTCTCGTACACGTCAGGTGCTTAGCCAAGGGCCTCTCCCTGGGGCATTCAAGCAAGGATGGCTCACATTGTTGG
CTTCTGGTTTGGAGAGTCTCACACCCCTAACAGTAAAAAAATCTTGATGGGCTGGGCACAGTGGCTCACACCTGTAATCC
CAGCACTTTGGGAGGCCAAAGCGAGAGATAGCTCGAGCCCAGGCGTTTGGGACCCGCCTGGGCAACATAGGGAGACCCTG
TCTCTACAAGAAATACAAAAATTAGCTGGGCAGGGTGGCGTGTGCCTGTAGCCCCAGCTACTCAGGAGGCTGAGGTAGGG
GGATTGCTTGAGTTCAGGAAGTCAAGACTGCAGTGAGCTATGATGGTGCCACTGTACTGTAGCCTGGGAGACCTGGTTTC
AAAGAAACAAAAAACAAATCAAAACAACAACAAAATGTTGCTGCCTCTACCTGTTTTATGAATATGTATAGAAATGACAT
GATGCACTACAACAGTATTAATTCAAGCTCTAGATCACACCTCAGAACCCCGAATTATAAAACAGGTGGCCGGGCGCGGT
GGCTCACGCCTGTAATCCCAGCACTTTGGGACACCGAGGTGGGCAGATCACGAGGTCAGGAGTTCAAGACCAGCCTGTCC
AACATCATGAAATCTGGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGTGCCTGTAACCCCAGCTACTCGGGA
GGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGTAGTGAGTCAAGATTGTGCCACTGCACTCCAGCCTGG
GTGACAGAGCAAGACTCCATCTCAATTTAAAAAAACAAACAAACAAACAAAAAAGAGTGGTAACATTGAAAATAAATAAG
TGTTCTAGTGTTTTCTCCCTGTACCTGCAGTTTGGCACCTGCAGCCCCAAAAGCTACCGCCAGGGGGAGGAACAACTGGC
TTTAAGTTCAGATTTCTCAGGTGGGCGAGGTGTTCCCACCTGGGGCTGGTAGGAGGCAGAGGGCAGCGGAGGCCTCCTTC
TTCCAAGAGGAGGAGTCCTGTGATCCCCACACTTTGGGAGGCCAAAGTGGGAGATCGCTTGAGCCCATGAGTTCAAGACC
AGCCTGGGCAACATAGGGAGACTCCGGGCTCAGAATAAACCTTCTGCCCAGAGAGTCACCATTATTCCAGGACGTGGCTC
AGATATGATAACAGCTTGCTTGAAGCCAAGTGCTTTTTGTGGTTGATGTCATGACACTCACCCCAAGACCCCGCTGGCCC
TTGTTTGTCAGCTTCTGTCAAAGTAAATGTTCACTGAGTTGATTCCCTACAGCAGGGAGGGAGATGATGGACAAGATGGA
GACACCATATACTGAGCATATAAGATGGTCATGGGTCCCTGGAACACAGTTAAGCTGGAAGGGGAGTCAGAAACGGTGTA
TGTGTTCGGGAAAGGGGGTGCTGTTGTAAACCCCATCTCTACGAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGC
CTGTAGTCCTAGTTACTCAGGAGGCTGAGGCATGAGAGTTGCTTGAACCTGGGAGGTGGAGGTTGCCCTGAGCTGAGATT
GCCCCACTGCACTCCAGCCTGGGTGACAGAGAGAGACTCCGTCTCAAAAAAAGAAAAAAAATGACACATCACATACAAAC
TATTATATAAAGGCCAGGCGCGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCAAAGTCAACGTCAGGAGTTTA
AGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCGTGCCTGT
AATCCCAGCTACTCAGGATGCTGAGGCAGGAGAATCACTTAAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTCCGC
CATTGCACTCCAACCTGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGGTAGTGC
ACACCTGTAGTCCCAGCTACTTGGGAGCTTGAGAGAGGAGGATTGCTTGAGCCCAGGATTTCAAGGCTACAGTGAGCTAT
GATCAAGCTACTGTACTCCAGCCTGGACCAGTAGAGCAAAATCCTGTCAAAAGAAAAAAAAAAAAAAACCATGTTGTCAA
AGAATAACAGAACGCAGAGGTATTTCGGTGGTTCTTTTCCACGCTGTTCAGTTATTTGCTTACTGTTCAGTTATTTGCAA
ATTGCTCACTCACATGTGAGGGAGTCAGTGGGTAGACTGAGTCAAGTACCAAAGGCAAAACCAAGATTTAGAATAGTGGG
CAAGGGAGGAAAGTTACAGGGCGTGTGGGAACAGTGACAGTGACTCTTGTCTGTAGGCTTTGGAGATAAGGTGGTTGCTG
GTAGGGAGCCCAGAAGGCAGTTAGAGCATTCTTTCTGCCCTTGAAGGGAAACAAACCCTTCCCGTTGTTTCTGGAGTCCC
TGGGAAACGCTGTCAGTTTGGCCCTGGGCCACACATGCGAGCCATCTCTGCGTAACCTCTGCCAGTGTCCTCTGTCAGCA
CCTGTTTTAGCGGCATTCCTCACAGGCAAACAACAGCTGCTCCAAAGGGGGTGGTTGTTTTAAGAAAAATGAGCGCGCAC
AAATGTCTGTGCAGAAAAGAACATTCCCACCTGTTTAATATGGAAAGTCTCACTGTCTTAAAAGAAAACAGTGGCCGGGC
GCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACGAGGTCAGGAGATCGAGACCATCC
TGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTAGGCATGGTGGCGCGTGCCTGTGTTCCCAGC
TACCTGGAAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCGGAGCTTGCAGTGAGCCAAGATTGCGCCACTGCACT
CCAGCCTGGCAACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAATAGCCACGCATGGTGGCGGGTGCCTGTAATCT
CAGCTACTTGAGAGGCGGAGGCAGGGAGAATTGCTTGAACTCAGGAGGCAGTGGTTGCAGTGAGCCGAGATAGCGCCATT
GTACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCTGAAAAAAAAAAAAAAGAAAAGAAAAGAAAAGAAAACAGTGGCT
GGGCATGGTGTCTCACGCCTGTAATCCCAACGCTTTGGGAGGCTGAAGTGGGAGGATCACTTGAGCCCAGGAGTTCAAGA
CCAGCCCGGGCAAATAGGGAGACCACCCCACCCCCCATCTCTACAAAAATAATTAAAAAGATAAAAAATTAGCCGGGCAT
GGTGGCATTTGCCTGTAGTCCCAGCTACTCAGTGGGCTGAGGTGGGAGGATGGCTTGAGCCCAGGAGGTGAAGGCTACAG
TGAGCTGTGATCAGACCACTACACTCCAGCCTGAGTGACAGAGCAAGACCCTGCCTCCAAAAAAAGAAAAGAACACAGGT
GAATATGCCATCTATGAAACAGGCCATAGTAAGAAAGGACCCTGGCTACTAAAGGGGAAGATAGTGATTAAAGCCAAGGA
AGGGCCAGGCATGATGACTCACACTGTAATCCCAGCACATTGGGAGGCTGAGGCAGAAGGCTCGCTGACCAGCCTGGGCA
ACATAGTGAGACCCCATCTCTACAGAAAATTTTAAAAATCAGCCAGATGTGGAGGCTGAGGTGGGAGGATTGCTTGAGCC
CAGGAGTTGGAGGCTGCAGTGAGCTATGATTGTACCACTGCACTATAGCCTGGGCGACAGAGTGAGACCTTGTCTCAAAT
ACATAAAAAAACATGGCTAGGCACAGTGGCTCATGTCTATAATCCCAGCACTTTGGGAGGCCGAGGCAAGCAAATCACGA
GGTCCAGAGTTCGAGACCAGCCTAGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGTCATGGT
GGTGCGTGCCTGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAAAATCTCTTGAACCTGGGAGTCAGAGGTTGCAGTGA
GCCGAGATTGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAACAAACAAACAAACAAACAAA
CAAACCACACCTAGTAAGCCCTCCTGATTCATTTATGTTAATGCTTGCCTAGAGCTGCCACATGCAGCTGTGCAGGGTGC
GCACTGCACAAGGATGCCACATCTGAGGGGGCTCCATTAATAACAGAGACATTGTAAATGTATGTTAATTTCAGCAATTA
ATGACAGGTGGAAATAAAGCATCTGGCTCTAATAAAACAACATTTTTTTTCTGAAAAATGAAAGCAAATGGCCTGAATTT
GCAGAATAAAAGCCACACAGGCTGTGGAGTGGCTGTGGGCCTGGCCTCATAGATATTTAGGTTTGGGCCCCTTTTTTTTT
TTTTTTTTTTTTAATTTTTTGTAGAGACAAGCGTCTTGATATGTTGCTCAGGCAGGTCTTGAACTCCTGGCCTCAAGTGA
TCCTCCCACCTCAGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCGCCATGCCCAGCCTGGCCCCTGCCTTTAAGCAG
CCTTGACTGTCACCCTTTAAGTGGCACCATTGGGATGAACAGAAGAGTCTTCAGATAAACCCTGCCACTTGCTTCTCCTC
CCTCCCTTCTCCACCTGTCCCCACCACCTCACTGCTCCTCGTGGCCCTCAACTCCCTACTGTGCCTTCTGGCCTACAAGG
GGTGGCTCACTCCTCACCCCTCTTCCCTCCATCTCTCCCTCTAGAACATAGATACCCTGGAGCGAATAGCCGGGCTGGAA
CAGGAGGACTTGGTGGAGGCGCACGGCACCTTCTACACATCACACTGCGTCAGCGCCAGCTGCCGGCACGAATACCCGCT
AAGCTGGATGAAAGGTGAGGCTGGAGGGCATCCTGAGGGCAGGCCTCCTCTCAGCACCAGGAGCAGTGTCTCCATGCAGT
GGGCACCCATTCTGTCCTGCTCAATTCTTTGGGGTTTTTTTGTTTTGTTTGTTTGTTTTTGAGACAGAGTCTCACTCTGT
CGCCCACGCGGGGAGTTCAGTGGGTGATCATGGCTCACTGCAGCCCAACTGCCTGATTTCCTGTCTTTGGCTGTTTTTAA
TATATGATAGTAGGCCAGGAGCAGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCAAGGCGGGCAGATCACCTGA
GGTCAGGAGTTCAAGACCAGCCTGGCTAACATGGTGAAACCCCGTTTCTACTAGAAATACAAAAAAAAAAAAATTAGCCT
GGTGTGGTGGCATGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGC
TGCAGTGAGCTGAGTTCGCACCATTGCACTCCAGCTTGGGCAACAAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAA
AAAAACAAGAAGTCACTTATTCCACTCATGGAAAGCCATTTCTGACATTCTTTATGCTGATTTAACAAAGCCTCTGGTGT
CCCTGTGAGATAAGGACAGCTGCAGCATTTGCAGAAGGGCCTCTGGAGTGTGGCTGTTCTGATAAAATGCCAGCTGAGTG
CCCCTGGGCTGAGGATTCCTGAATAGCCCAACTGCAAGCAGCTGGGGGCAGTGTACAATTCACATTACCCCCATTATGTG
TCATTGACAGCAGCGTCACAGGCAGCACCCACGGTGTCATGCTGTCCATGCAGAAATATTTTAAAGAAAATTACCGACTA
CTGACATTGAAACAATGCTTTATAAATGTGTGCTGAATGAATGAATGGACAGTTGAGCAAATGACTTAGAATTCAGTGGG
TTGCAAGTGACAGAAATGCTTTCTTTCTTTCTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGT
GCAGTGGTGCAATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCAATTCTCCCTGCCTCGGCCTCCCAAGTAGC
TGGGATTACAGGCACGTGCTACAACCCCTGGCTAATTTTTATATTTTTAGTAGAGACGGGGTTTCACCACGTTGGCCAGG
CTGGTCTCAAACTCCTGACCTCAAACGATCCACTCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAC
ACCCGGCCAGAAATGCTTTCAAGCTTCCTAAATCAATAAGAAATAAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCAA
CACTTTTGGACGTCGAGGTGGGTGGATCACTTGAGCCCAGGAGTTTGAGAACAGCCTGGGCAACATAGGGAGATCCCATC
TCTAAAAAAAATAAAATGTAGCCAGGTGCGATGGTGGATGCCTGTGAGCCCAGCTACTCGGGAGGCTAAGGCAGGAGGAT
CACTTGAGCCTGGGAAGTCGGTGGTGCAGTAAGCTATGATCACACCACTGCACTCAACCATGATTGCACCACCACACTCC
AGCCTGGGCAACAGAGTGAGAACCTGTCTCAAAAAAACAAACAAACCAATAAGGCCGGGCGCAGTGGCTCACACCTGTAA
TTGCAGCTCTTTGAGAAGCCAAAGTGGGCAGATTTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATGGCGAAA
CCCTGTCTCTACAAAAAATACAAAATTTAGCCGGGCGTGCTGGCATGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGG
CAGGAGGATCACTTGAAGCTGGGAGGTTGAGGCTACAGTAAGCCATGATCGTGCCACTGCATTCCAGCCCGGGCAACAGA
GTGAGACCTTATCTCAAAAAAAAAAAGAAAGAAAAAAACAAAAAAAATGCAACAACAAGAAGAGAGGTCTTTTCTGAGCA
GAGTGGACACCTCAGGAGACACCCATCACACTCCAAGTGATGGAGGTGTGTTCATGTTAACAGTGGAAGAGGGGTGGGGG
TGCTGCACCTCCAGACTCCGGCCCAGATCCTCTTACTGCCTTCTCTTTCTTCCCCTTCCCCATACCCAGAGAAGATCTTC
TCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGGTGAGCCTCTGGCCAGGGACCTGCCCAGGTG
GATTTGGGTGGGGGTCCCCTCCTCCCCCTGACCCCCTCCCAAAGGCCACACCCGCACACATCTGGCCACCTCTGTCTCTC
TGAACAGTGCCCCAGATCCATCCTGGGGAGAATGGGGTCTGTGCCCCTGGCCGGTCCCCACTGCTCCCAACTCCCACTGT
GGCCTCCGGGTCTGCCATTGCTCCCACCTGTCCTCTCTGCCTCCCCATGTCACTGTCTCTGTCCGTCCATCTGTCTCCAC
CTCAGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGTAAGTGGCCCCCCAGCCT
CCCCGCATCCCCAACCGCCGCCTCCACCTGTGCTGGGCCCCATGGGGGCAGCCTGGGCCCTGCCTCAGGAAAGGTCACCT
CCCCAGCTATGGGGGGCGGCAGGGAGGTTTGCTGCTGGGGGCGGGGGAGGGAGCGGTGGCGCAGCCTGGGCGGAGGCTCC
CAAGCTCACGCCCCTCCCCGCAGGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCC
TTTGCCTCCCTCATCAGCAAGTAGGTTGGGGGCTGTGGCTGGGAGGACGGCTGGGCACCCAGGGCCAGGACAGACCCTGA
CCCCTTAGCTCCCCCTCCCCACAGGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGGTAA
GAGCCCTTCTTCAAGCCCCCGTCGTCACAGGCTCCCCCTTCCCTCTCACCCTTTTCCTCAGAGGGAACCCCCACTGTGGA
ACCCCAGCACTTTGCATTCCTCAGCTCAGAACCTGGGGCTCTAGAATCCAGAGGGGTCGGGTTCCAGGCCTCTGGGACAT
TCACTGCCCTTTTGAGCAAGTGATAGAATTCCAACTCAAACCAGCTGAAGCCAGATAGGAAGGCCGGGCTTCCAGGGACT
GAGGAGGTGGGAGGGGGTGCAGGGGTCAGGAGAGACAGTGCGGGGGGCGGGGTTGGGTCCACGCTCTGGGTCTCTCAGGT
CTGTTTTTCCTGGGCAGCCTCACTCTAGGGCAGGTGCTCCCTCCTAGGTGTTCCCCTCAGGGGAAGTAGGCAGGGTCACC
GGGCAAGCAGCGCACGCTGTGGGCAGACACTGTCCCAAGTCTTAGCCTGCGTGAACTCACTGGCGCCACAACCCCATCGC
GGTTTTGTGATCACCCCTATTCTACAGGAAACTAAGACACAGAGAGGACAAGTCACTTGACCAAAGTCACTGAGCTGGCT
GGGCGCAATGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGA
CCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAATAATACAAAATTAGCCGGGCATGGTGCTGGGCACCTGTCATC
CAGGCTACTCGGGAGGTTGAGGCGGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATCACATCATT
GCACTCCAGCCTGGGCAACAAGAGTGAAACTTTGTCTCAAAAAAAACCAAAAAAACAACAACAAAAAAAAAACAAAGTCA
CAGAGCTAGGATACAAACCCAGGCCACCTGGCTCCAGGGTCTGTGCTCTTAGCTCTCCCTTCCCTGCTCCTGCCCCTGAC
CCACCCCCTCCCTGACAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAA
GGCCTACAGGTGAGGCCCCGCCGGGGGTTGGGGCAGCCTGGAAGGGACAGGGTGAGGTGGGAGCGGGGGCACGAAGGCAG
ATGAGAGGAGCAGGCAGGGGCGAGCCCGCCTGGGAACTCTGATCTCCTGCTGCACCGCAGGGACGTGGCCTGGCTGGGTG
AATGCGACCAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGGTGAGGAGCTGAGCAACCCCAGCCTGTCCTGAG
CCCCATCCCTGGACCCTCTCCCCACCCCATGGGTCCTCTGACCCCATGATGCACAGTGACCTTTGACTTCTGTGACCTTT
GCTCCTGCAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCA
ACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCC
CAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTA
ACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAAC
CCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTC
TCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTA
ACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAA
CCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAG
TCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAAGACA
TTGCTTATTGGAGACAAATTAAAAACAAAAACAACTAACAAT
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Primary source |
RefSeq : NM_012237.2 (GI:13775599)
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Name |
Sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2), transcript variant 1
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
1963 nt
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Map |
19q13
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Location |
Chromosome 19 (NC_000019.9) strand : -
39369201...39369949 | 39370073...39370139 | 39370271...39370341 | 39371324...39371375 |
39371460...39371536 | 39371739...39371794 | 39372071...39372130 | 39374266...39374395 |
39379726...39379794 | 39380328...39380384 | 39380494...39380600 | 39380742...39380783 |
39384053...39384166 | 39384458...39384506 | 39389018...39389064 | 39390145...39390360 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1a
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1
|
216
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216
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1
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Exon 2
|
217
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263
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47
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1
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Exon 3
|
264
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312
|
49
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1
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Exon 4
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313
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426
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114
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1
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Exon 5
|
427
|
468
|
42
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1
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Exon 6
|
469
|
575
|
107
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1
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Exon 7
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576
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632
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57
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1
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Exon 8
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633
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701
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69
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1
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Exon 9
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702
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831
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130
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1
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Exon 10
|
832
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891
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60
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1
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Exon 11
|
892
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947
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56
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1
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Exon 12
|
948
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1024
|
77
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1
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Exon 13
|
1025
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1076
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52
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1
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Exon 14
|
1077
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1147
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71
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1
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Exon 15
|
1148
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1214
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67
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1
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Exon 16a
|
1215
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1963
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749
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1
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Primary source |
NCBI : CCDS12523
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Nucleotide |
SIRT2, mRNA isoform 1[NM_012237.2] : 201...1370
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Length |
1170
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Location |
Chromosome 19 (NC_000019.9) strand : -
39369794...39369949 | 39370073...39370139 | 39370271...39370341 | 39371324...39371375 |
39371460...39371536 | 39371739...39371794 | 39372071...39372130 | 39374266...39374395 |
39379726...39379794 | 39380328...39380384 | 39380494...39380600 | 39380742...39380783 |
39384053...39384166 | 39384458...39384506 | 39389018...39389064 | 39390145...39390160 |
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Start codon |
1
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Translation |
NP_036369.2 |
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1 |
GTGTTGTACG |
AAAGCGCGTC |
TGCGGCCGCA |
ATGTCTGCTG |
AGAGTTGTAG |
TTCTGTGCCC |
TATCACGGCC |
ACTCCCATTT |
|
81 |
CTGGTGCCGT |
CACGGGACAG |
AGCAGTCGGT |
GACAGGACAG |
AGCAGTCGGT |
GACGGGACAC |
AGTGGTTGGT |
GACGGGACAG |
|
161 |
AGCGGTCGGT |
GACAGCCTCA |
AGGGCTTCAG |
CACCGCGCCC |
ATGGCAGAGC |
CAGACCCCTC |
TCACCCTCTG |
GAGACCCAGG |
|
241 |
CAGGGAAGGT |
GCAGGAGGCT |
CAGGACTCAG |
ATTCAGACTC |
TGAGGGAGGA |
GCCGCTGGTG |
GAGAAGCAGA |
CATGGACTTC |
|
321 |
CTGCGGAACT |
TATTCTCCCA |
GACGCTCAGC |
CTGGGCAGCC |
AGAAGGAGCG |
TCTGCTGGAC |
GAGCTGACCT |
TGGAAGGGGT |
|
401 |
GGCCCGGTAC |
ATGCAGAGCG |
AACGCTGTCG |
CAGAGTCATC |
TGTTTGGTGG |
GAGCTGGAAT |
CTCCACATCC |
GCAGGCATCC |
|
481 |
CCGACTTTCG |
CTCTCCATCC |
ACCGGCCTCT |
ATGACAACCT |
AGAGAAGTAC |
CATCTTCCCT |
ACCCAGAGGC |
CATCTTTGAG |
|
561 |
ATCAGCTATT |
TCAAGAAACA |
TCCGGAACCC |
TTCTTCGCCC |
TCGCCAAGGA |
ACTCTATCCT |
GGGCAGTTCA |
AGCCAACCAT |
|
641 |
CTGTCACTAC |
TTCATGCGCC |
TGCTGAAGGA |
CAAGGGGCTA |
CTCCTGCGCT |
GCTACACGCA |
GAACATAGAT |
ACCCTGGAGC |
|
721 |
GAATAGCCGG |
GCTGGAACAG |
GAGGACTTGG |
TGGAGGCGCA |
CGGCACCTTC |
TACACATCAC |
ACTGCGTCAG |
CGCCAGCTGC |
|
801 |
CGGCACGAAT |
ACCCGCTAAG |
CTGGATGAAA |
GAGAAGATCT |
TCTCTGAGGT |
GACGCCCAAG |
TGTGAAGACT |
GTCAGAGCCT |
|
881 |
GGTGAAGCCT |
GATATCGTCT |
TTTTTGGTGA |
GAGCCTCCCA |
GCGCGTTTCT |
TCTCCTGTAT |
GCAGTCAGAC |
TTCCTGAAGG |
|
961 |
TGGACCTCCT |
CCTGGTCATG |
GGTACCTCCT |
TGCAGGTGCA |
GCCCTTTGCC |
TCCCTCATCA |
GCAAGGCACC |
CCTCTCCACC |
|
1041 |
CCTCGCCTGC |
TCATCAACAA |
GGAGAAAGCT |
GGCCAGTCGG |
ACCCTTTCCT |
GGGGATGATT |
ATGGGCCTCG |
GAGGAGGCAT |
|
1121 |
GGACTTTGAC |
TCCAAGAAGG |
CCTACAGGGA |
CGTGGCCTGG |
CTGGGTGAAT |
GCGACCAGGG |
CTGCCTGGCC |
CTTGCTGAGC |
|
1201 |
TCCTTGGATG |
GAAGAAGGAG |
CTGGAGGACC |
TTGTCCGGAG |
GGAGCACGCC |
AGCATAGATG |
CCCAGTCGGG |
GGCGGGGGTC |
|
1281 |
CCCAACCCCA |
GCACTTCAGC |
TTCCCCCAAG |
AAGTCCCCGC |
CACCTGCCAA |
GGACGAGGCC |
AGGACAACAG |
AGAGGGAGAA |
|
1361 |
ACCCCAGTGA |
CAGCTGCATC |
TCCCAGGCGG |
GATGCCGAGC |
TCCTCAGGGA |
CAGCTGAGCC |
CCAACCGGGC |
CTGGCCCCCT |
|
1441 |
CTTAACCAGC |
AGTTCTTGTC |
TGGGGAGCTC |
AGAACATCCC |
CCAATCTCTT |
ACAGCTCCCT |
CCCCAAAACT |
GGGGTCCCAG |
|
1521 |
CAACCCTGGC |
CCCCAACCCC |
AGCAAATCTC |
TAACACCTCC |
TAGAGGCCAA |
GGCTTAAACA |
GGCATCTCTA |
CCAGCCCCAC |
|
1601 |
TGTCTCTAAC |
CACTCCTGGG |
CTAAGGAGTA |
ACCTCCCTCA |
TCTCTAACTG |
CCCCCACGGG |
GCCAGGGCTA |
CCCCAGAACT |
|
1681 |
TTTAACTCTT |
CCAGGACAGG |
GAGCTTCGGG |
CCCCCACTCT |
GTCTCCTGCC |
CCCGGGGGCC |
TGTGGCTAAG |
TAAACCATAC |
|
1761 |
CTAACCTACC |
CCAGTGTGGG |
TGTGGGCCTC |
TGAATATAAC |
CCACACCCAG |
CGTAGGGGGA |
GTCTGAGCCG |
GGAGGGCTCC |
|
1841 |
CGAGTCTCTG |
CCTTCAGCTC |
CCAAAGTGGG |
TGGTGGGCCC |
CCTTCACGTG |
GGACCCACTT |
CCCATGCTGG |
ATGGGCAGAA |
|
1921 |
GACATTGCTT |
ATTGGAGACA |
AATTAAAAAC |
AAAAACAACT |
AAC |
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>gi|13775599|ref|NM_012237.2|Sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2), transcript variant 1
GTGTTGTACGAAAGCGCGTCTGCGGCCGCAATGTCTGCTGAGAGTTGTAGTTCTGTGCCCTATCACGGCCACTCCCATTT
CTGGTGCCGTCACGGGACAGAGCAGTCGGTGACAGGACAGAGCAGTCGGTGACGGGACACAGTGGTTGGTGACGGGACAG
AGCGGTCGGTGACAGCCTCAAGGGCTTCAGCACCGCGCCCATGGCAGAGCCAGACCCCTCTCACCCTCTGGAGACCCAGG
CAGGGAAGGTGCAGGAGGCTCAGGACTCAGATTCAGACTCTGAGGGAGGAGCCGCTGGTGGAGAAGCAGACATGGACTTC
CTGCGGAACTTATTCTCCCAGACGCTCAGCCTGGGCAGCCAGAAGGAGCGTCTGCTGGACGAGCTGACCTTGGAAGGGGT
GGCCCGGTACATGCAGAGCGAACGCTGTCGCAGAGTCATCTGTTTGGTGGGAGCTGGAATCTCCACATCCGCAGGCATCC
CCGACTTTCGCTCTCCATCCACCGGCCTCTATGACAACCTAGAGAAGTACCATCTTCCCTACCCAGAGGCCATCTTTGAG
ATCAGCTATTTCAAGAAACATCCGGAACCCTTCTTCGCCCTCGCCAAGGAACTCTATCCTGGGCAGTTCAAGCCAACCAT
CTGTCACTACTTCATGCGCCTGCTGAAGGACAAGGGGCTACTCCTGCGCTGCTACACGCAGAACATAGATACCCTGGAGC
GAATAGCCGGGCTGGAACAGGAGGACTTGGTGGAGGCGCACGGCACCTTCTACACATCACACTGCGTCAGCGCCAGCTGC
CGGCACGAATACCCGCTAAGCTGGATGAAAGAGAAGATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCT
GGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCTGAAGG
TGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCTCATCAGCAAGGCACCCCTCTCCACC
CCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCAT
GGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGCTGAGC
TCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTC
CCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAA
ACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCT
CTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAG
CAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCAC
TGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACT
TTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATAC
CTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCC
CGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAA
GACATTGCTTATTGGAGACAAATTAAAAACAAAAACAACTAAC
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Primary source |
RefSeq : NM_030593.1 (GI:13775601)
|
Name |
Sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2), transcript variant 2
|
Type of transcript |
mRNA
|
Organism |
Homo sapiens
|
Length |
1931 nt
|
Map |
19q13
|
Location |
Chromosome 19 (NC_000019.9) strand : -
39369199...39369949 | 39370073...39370139 | 39370271...39370341 | 39371324...39371375 |
39371460...39371536 | 39371739...39371794 | 39372071...39372130 | 39374266...39374395 |
39379726...39379794 | 39380328...39380384 | 39380494...39380600 | 39380742...39380783 |
39384053...39384166 | 39384458...39384506 | 39390145...39390352 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1b
|
1
|
208
|
208
|
1
|
Exon 3
|
209
|
257
|
49
|
1
|
Exon 4
|
258
|
371
|
114
|
1
|
Exon 5
|
372
|
413
|
42
|
1
|
Exon 6
|
414
|
520
|
107
|
1
|
Exon 7
|
521
|
577
|
57
|
1
|
Exon 8
|
578
|
646
|
69
|
1
|
Exon 9
|
647
|
776
|
130
|
1
|
Exon 10
|
777
|
836
|
60
|
1
|
Exon 11
|
837
|
892
|
56
|
1
|
Exon 12
|
893
|
969
|
77
|
1
|
Exon 13
|
970
|
1021
|
52
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1
|
Exon 14
|
1022
|
1092
|
71
|
1
|
Exon 15
|
1093
|
1159
|
67
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1
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Exon 16b
|
1160
|
1910
|
751
|
1
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ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
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Primary source |
NCBI : CCDS46069
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Nucleotide |
SIRT2, mRNA isoform 2[NM_030593.1] : 257...1315
|
Length |
1059
|
Location |
Chromosome 19 (NC_000019.9) strand : -
39369794...39369949 | 39370073...39370139 | 39370271...39370341 | 39371324...39371375 |
39371460...39371536 | 39371739...39371794 | 39372071...39372130 | 39374266...39374395 |
39379726...39379794 | 39380328...39380384 | 39380494...39380600 | 39380742...39380783 |
39384053...39384166 | 39384458...39384458 |
|
Start codon |
1
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Translation |
NP_085096.1 |
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1 |
CGAAAGCGCG |
TCTGCGGCCG |
CAATGTCTGC |
TGAGAGTTGT |
AGTTCTGTGC |
CCTATCACGG |
CCACTCCCAT |
TTCTGGTGCC |
|
81 |
GTCACGGGAC |
AGAGCAGTCG |
GTGACAGGAC |
AGAGCAGTCG |
GTGACGGGAC |
ACAGTGGTTG |
GTGACGGGAC |
AGAGCGGTCG |
|
161 |
GTGACAGCCT |
CAAGGGCTTC |
AGCACCGCGC |
CCATGGCAGA |
GCCAGACCGA |
CTCAGATTCA |
GACTCTGAGG |
GAGGAGCCGC |
|
241 |
TGGTGGAGAA |
GCAGACATGG |
ACTTCCTGCG |
GAACTTATTC |
TCCCAGACGC |
TCAGCCTGGG |
CAGCCAGAAG |
GAGCGTCTGC |
|
321 |
TGGACGAGCT |
GACCTTGGAA |
GGGGTGGCCC |
GGTACATGCA |
GAGCGAACGC |
TGTCGCAGAG |
TCATCTGTTT |
GGTGGGAGCT |
|
401 |
GGAATCTCCA |
CATCCGCAGG |
CATCCCCGAC |
TTTCGCTCTC |
CATCCACCGG |
CCTCTATGAC |
AACCTAGAGA |
AGTACCATCT |
|
481 |
TCCCTACCCA |
GAGGCCATCT |
TTGAGATCAG |
CTATTTCAAG |
AAACATCCGG |
AACCCTTCTT |
CGCCCTCGCC |
AAGGAACTCT |
|
561 |
ATCCTGGGCA |
GTTCAAGCCA |
ACCATCTGTC |
ACTACTTCAT |
GCGCCTGCTG |
AAGGACAAGG |
GGCTACTCCT |
GCGCTGCTAC |
|
641 |
ACGCAGAACA |
TAGATACCCT |
GGAGCGAATA |
GCCGGGCTGG |
AACAGGAGGA |
CTTGGTGGAG |
GCGCACGGCA |
CCTTCTACAC |
|
721 |
ATCACACTGC |
GTCAGCGCCA |
GCTGCCGGCA |
CGAATACCCG |
CTAAGCTGGA |
TGAAAGAGAA |
GATCTTCTCT |
GAGGTGACGC |
|
801 |
CCAAGTGTGA |
AGACTGTCAG |
AGCCTGGTGA |
AGCCTGATAT |
CGTCTTTTTT |
GGTGAGAGCC |
TCCCAGCGCG |
TTTCTTCTCC |
|
881 |
TGTATGCAGT |
CAGACTTCCT |
GAAGGTGGAC |
CTCCTCCTGG |
TCATGGGTAC |
CTCCTTGCAG |
GTGCAGCCCT |
TTGCCTCCCT |
|
961 |
CATCAGCAAG |
GCACCCCTCT |
CCACCCCTCG |
CCTGCTCATC |
AACAAGGAGA |
AAGCTGGCCA |
GTCGGACCCT |
TTCCTGGGGA |
|
1041 |
TGATTATGGG |
CCTCGGAGGA |
GGCATGGACT |
TTGACTCCAA |
GAAGGCCTAC |
AGGGACGTGG |
CCTGGCTGGG |
TGAATGCGAC |
|
1121 |
CAGGGCTGCC |
TGGCCCTTGC |
TGAGCTCCTT |
GGATGGAAGA |
AGGAGCTGGA |
GGACCTTGTC |
CGGAGGGAGC |
ACGCCAGCAT |
|
1201 |
AGATGCCCAG |
TCGGGGGCGG |
GGGTCCCCAA |
CCCCAGCACT |
TCAGCTTCCC |
CCAAGAAGTC |
CCCGCCACCT |
GCCAAGGACG |
|
1281 |
AGGCCAGGAC |
AACAGAGAGG |
GAGAAACCCC |
AGTGACAGCT |
GCATCTCCCA |
GGCGGGATGC |
CGAGCTCCTC |
AGGGACAGCT |
|
1361 |
GAGCCCCAAC |
CGGGCCTGGC |
CCCCTCTTAA |
CCAGCAGTTC |
TTGTCTGGGG |
AGCTCAGAAC |
ATCCCCCAAT |
CTCTTACAGC |
|
1441 |
TCCCTCCCCA |
AAACTGGGGT |
CCCAGCAACC |
CTGGCCCCCA |
ACCCCAGCAA |
ATCTCTAACA |
CCTCCTAGAG |
GCCAAGGCTT |
|
1521 |
AAACAGGCAT |
CTCTACCAGC |
CCCACTGTCT |
CTAACCACTC |
CTGGGCTAAG |
GAGTAACCTC |
CCTCATCTCT |
AACTGCCCCC |
|
1601 |
ACGGGGCCAG |
GGCTACCCCA |
GAACTTTTAA |
CTCTTCCAGG |
ACAGGGAGCT |
TCGGGCCCCC |
ACTCTGTCTC |
CTGCCCCCGG |
|
1681 |
GGGCCTGTGG |
CTAAGTAAAC |
CATACCTAAC |
CTACCCCAGT |
GTGGGTGTGG |
GCCTCTGAAT |
ATAACCCACA |
CCCAGCGTAG |
|
1761 |
GGGGAGTCTG |
AGCCGGGAGG |
GCTCCCGAGT |
CTCTGCCTTC |
AGCTCCCAAA |
GTGGGTGGTG |
GGCCCCCTTC |
ACGTGGGACC |
|
1841 |
CACTTCCCAT |
GCTGGATGGG |
CAGAAGACAT |
TGCTTATTGG |
AGACAAATTA |
AAAACAAAAA |
CAACTAACAA |
AAAAAAAAAA |
|
1921 |
AAAAAAAAAA |
A |
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>gi|13775601|ref|NM_030593.1|Sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2), transcript variant 2
CGAAAGCGCGTCTGCGGCCGCAATGTCTGCTGAGAGTTGTAGTTCTGTGCCCTATCACGGCCACTCCCATTTCTGGTGCC
GTCACGGGACAGAGCAGTCGGTGACAGGACAGAGCAGTCGGTGACGGGACACAGTGGTTGGTGACGGGACAGAGCGGTCG
GTGACAGCCTCAAGGGCTTCAGCACCGCGCCCATGGCAGAGCCAGACCGACTCAGATTCAGACTCTGAGGGAGGAGCCGC
TGGTGGAGAAGCAGACATGGACTTCCTGCGGAACTTATTCTCCCAGACGCTCAGCCTGGGCAGCCAGAAGGAGCGTCTGC
TGGACGAGCTGACCTTGGAAGGGGTGGCCCGGTACATGCAGAGCGAACGCTGTCGCAGAGTCATCTGTTTGGTGGGAGCT
GGAATCTCCACATCCGCAGGCATCCCCGACTTTCGCTCTCCATCCACCGGCCTCTATGACAACCTAGAGAAGTACCATCT
TCCCTACCCAGAGGCCATCTTTGAGATCAGCTATTTCAAGAAACATCCGGAACCCTTCTTCGCCCTCGCCAAGGAACTCT
ATCCTGGGCAGTTCAAGCCAACCATCTGTCACTACTTCATGCGCCTGCTGAAGGACAAGGGGCTACTCCTGCGCTGCTAC
ACGCAGAACATAGATACCCTGGAGCGAATAGCCGGGCTGGAACAGGAGGACTTGGTGGAGGCGCACGGCACCTTCTACAC
ATCACACTGCGTCAGCGCCAGCTGCCGGCACGAATACCCGCTAAGCTGGATGAAAGAGAAGATCTTCTCTGAGGTGACGC
CCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATATCGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCC
TGTATGCAGTCAGACTTCCTGAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCT
CATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCAGTCGGACCCTTTCCTGGGGA
TGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAAGAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGAC
CAGGGCTGCCTGGCCCTTGCTGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCAT
AGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACG
AGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCTGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCT
GAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGC
TCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTT
AAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTCCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCC
ACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGG
GGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAG
GGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTCAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACC
CACTTCCCATGCTGGATGGGCAGAAGACATTGCTTATTGGAGACAAATTAAAAACAAAAACAACTAACAAAAAAAAAAAA
AAAAAAAAAAA
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Exon number |
1a
|
Length |
216 nt
|
Location |
Chromosome 19 (NC_000019.9) : 39390145...39390360 (-)
|
Is part of |
SIRT2, mRNA isoform 1
(NM_012237.2)
|
Sequence |
Show
|
|
GTGTTGTACGAAAGCGCGTCTGCGGCCGCAATGTCTGCTGAGAGTTGTAGTTCTGTGCCCTATCACGGCCACTCCCATTT
CTGGTGCCGTCACGGGACAGAGCAGTCGGTGACAGGACAGAGCAGTCGGTGACGGGACACAGTGGTTGGTGACGGGACAG
AGCGGTCGGTGACAGCCTCAAGGGCTTCAGCACCGCGCCCATGGCAGAGCCAGACC
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Exon number |
1b
|
Length |
208 nt
|
Location |
Chromosome 19 (NC_000019.9) : 39390145...39390352 (-)
|
Is part of |
SIRT2, mRNA isoform 2
(NM_030593.1)
|
Sequence |
Show
|
|
CGAAAGCGCGTCTGCGGCCGCAATGTCTGCTGAGAGTTGTAGTTCTGTGCCCTATCACGGCCACTCCCATTTCTGGTGCC
GTCACGGGACAGAGCAGTCGGTGACAGGACAGAGCAGTCGGTGACGGGACACAGTGGTTGGTGACGGGACAGAGCGGTCG
GTGACAGCCTCAAGGGCTTCAGCACCGCGCCCATGGCAGAGCCAGACC
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Exon number |
16a
|
Length |
749 nt
|
Location |
Chromosome 19 (NC_000019.9) : 39369201...39369949 (-)
|
Is part of |
SIRT2, mRNA isoform 1
(NM_012237.2)
|
Sequence |
Show
|
|
AAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCAC
TTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGC
TGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTT
CTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCC
AACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACT
CCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAG
GACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAG
TGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTT
CAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAAGACATTGCTTATTG
GAGACAAATTAAAAACAAAAACAACTAAC
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Exon number |
16b
|
Length |
751 nt
|
Location |
Chromosome 19 (NC_000019.9) : 39369199...39369949 (-)
|
Is part of |
SIRT2, mRNA isoform 2
(NM_030593.1)
|
Sequence |
Show
|
|
AAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCATAGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCAC
TTCAGCTTCCCCCAAGAAGTCCCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGC
TGCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGCCCCCTCTTAACCAGCAGTT
CTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGCTCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCC
AACCCCAGCAAATCTCTAACACCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACT
CCTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCAGAACTTTTAACTCTTCCAG
GACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGGGGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAG
TGTGGGTGTGGGCCTCTGAATATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTT
CAGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGGCAGAAGACATTGCTTATTG
GAGACAAATTAAAAACAAAAACAACTAACAA
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Primary source |
Uniprot : Q8IXJ6
|
Name |
NAD-dependent deacetylase sirtuin-2
|
Alternative name(s) |
SIR2-like protein 2
|
Synonym(s) |
|
Organism |
Homo sapiens
|
Length |
389 aa
|
Protein existence |
---
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General annotation (Comments)
|
top
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Catalytic activity
|
NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein.
|
Cofactor
|
Binds 1 zinc ion per subunit.
|
Developmental stage
|
Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
|
Enzyme regulation
|
Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide.
|
Function
|
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
|
Ptm
|
Phosphorylated at the G2/M transition of the cell cycle.
|
Similarity
|
Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
|
Subcellular location
|
Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
|
Subunit
|
Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton.
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Tissue specificity
|
Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
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Biological process
|
chromatin silencing at rDNA [GO:0000183]
chromatin silencing at telomere [GO:0006348]
protein amino acid ADP-ribosylation [GO:0006471]
mitosis [GO:0007067]
regulation of exit from mitosis [GO:0007096]
histone deacetylation [GO:0016575]
regulation of phosphorylation [GO:0042325]
negative regulation of striated muscle tissue development [GO:0045843]
cell division [GO:0051301]
response to redox state [GO:0051775]
|
Cellular component
|
chromatin silencing complex [GO:0005677]
cytoplasm [GO:0005737]
microtubule [GO:0005874]
|
Molecular function
|
transcription factor binding [GO:0008134]
zinc ion binding [GO:0008270]
NAD-dependent histone deacetylase activity [GO:0017136]
histone acetyltransferase binding [GO:0035035]
histone deacetylase binding [GO:0042826]
tubulin deacetylase activity [GO:0042903]
ubiquitin binding [GO:0043130]
NAD binding [GO:0070403]
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With
|
Uniprot accession
|
IntAct
|
HDAC6
|
Q9UBN7
|
EBI-477232,EBI-301697
|
MYOD1
|
P15172
|
EBI-477232,EBI-488878
|
KAT2B
|
Q92831
|
EBI-477232,EBI-477430
|
RTN4
|
Q9NQC3
|
EBI-477232,EBI-715945
|
-
|
Q9Y569
|
EBI-477232,
|
PHB2
|
Q99623
|
EBI-477232,EBI-358348
|
GYS1
|
P13807
|
EBI-477232,EBI-963094
|
KAT2A
|
Q92830-2
|
EBI-477232,EBI-477641
|
KRT78
|
Q8N1N4
|
EBI-477232,EBI-1056564
|
KAT2A
|
Q92830-1
|
EBI-477232,
|
SPOP
|
O43791
|
EBI-477232,
|
SARS
|
P49591
|
EBI-477232,EBI-1053431
|
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Alternative product(s)
|
top
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  |
Uniprot Identifier
|
Difference(s) with the 'canonical' sequence
|
Notes
|
Sequences
|
Isoform 1
|
Q8IXJ6-1
|
---
|
'Canonical' sequence
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Get Fasta
|
Isoform 2
|
Q8IXJ6-2
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1-37 : Missing
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---
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Get Fasta
|
Isoform 3
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Q8IXJ6-3
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1-38 : MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADM -> MPLAECPSCRCLSSFRSV
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---
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Get Fasta
|
Isoform 4
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Q8IXJ6-4
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266-271 : VQPFAS -> GRGLAG
272-389 : Missing
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---
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Get Fasta
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Feature key |
Position
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Length
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Description
|
Feature identifier
|
Molecule processing |
|
|
|
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Initiator methionine
|
1 - 1
|
1
|
Removed
|
Q8IXJ6-INIT_MET-1
|
Region |
|
|
|
|
Domain
|
65 - 340
|
276
|
Deacetylase sirtuin-type
|
Q8IXJ6-DOMAIN-65
|
Nucleotide binding
|
84 - 104
|
21
|
NAD (By similarity)
|
Q8IXJ6-NP_BIND-84
|
Nucleotide binding
|
167 - 171
|
5
|
NAD (By similarity)
|
Q8IXJ6-NP_BIND-167
|
Sites |
|
|
|
|
Active site
|
187 - 187
|
1
|
Proton acceptor
|
Q8IXJ6-ACT_SITE-187
|
Metal binding
|
195 - 195
|
1
|
Zinc
|
Q8IXJ6-METAL-195
|
Metal binding
|
200 - 200
|
1
|
Zinc
|
Q8IXJ6-METAL-200
|
Metal binding
|
221 - 221
|
1
|
Zinc
|
Q8IXJ6-METAL-221
|
Metal binding
|
224 - 224
|
1
|
Zinc
|
Q8IXJ6-METAL-224
|
Natural variations |
|
|
|
|
Alternative sequence
|
1 - 37
|
37
|
Missing
|
VSP_008724
|
Alternative sequence
|
1 - 38
|
38
|
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADM -> MPLAECPSCRCLSSFRSV
|
VSP_008726
|
Alternative sequence
|
266 - 271
|
6
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VQPFAS -> GRGLAG
|
VSP_008727
|
Alternative sequence
|
272 - 389
|
118
|
Missing
|
VSP_008728
|
Amino acid modifications |
|
|
|
|
Modified residue
|
2 - 2
|
1
|
N-acetylalanine
|
Q8IXJ6-MOD_RES-2
|
Modified residue
|
23 - 23
|
1
|
Phosphoserine
|
Q8IXJ6-MOD_RES-23
|
Modified residue
|
25 - 25
|
1
|
Phosphoserine
|
Q8IXJ6-MOD_RES-25
|
Modified residue
|
27 - 27
|
1
|
Phosphoserine
|
Q8IXJ6-MOD_RES-27
|
Modified residue
|
368 - 368
|
1
|
Phosphoserine
|
Q8IXJ6-MOD_RES-368
|
Modified residue
|
372 - 372
|
1
|
Phosphoserine
|
Q8IXJ6-MOD_RES-372
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Experimental info |
|
|
|
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Mutagenesis
|
97 - 97
|
1
|
R->A: No effect on deacetylase activity
|
Q8IXJ6-MUTAGEN-97
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Mutagenesis
|
167 - 167
|
1
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Q->A: Reduced deacetylase activity
|
Q8IXJ6-MUTAGEN-167
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Mutagenesis
|
168 - 168
|
1
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N->A: Abolishes acetylation of alpha- tubulin
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Q8IXJ6-MUTAGEN-168
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Mutagenesis
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170 - 170
|
1
|
D->A,N: Reduced deacetylase activity
|
Q8IXJ6-MUTAGEN-170
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Mutagenesis
|
187 - 187
|
1
|
H->Y,A: Loss of function. Abolishes acetylation of alpha-tubulin. No effect on phosphorylation
|
Q8IXJ6-MUTAGEN-187
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1 |
MAEPDPSHPL |
ETQAGKVQEA |
QDSDSDSEGG |
AAGGEADMDF |
LRNLFSQTLS |
LGSQKERLLD |
ELTLEGVARY |
MQSERCRRVI |
|
81 |
CLVGAGISTS |
AGIPDFRSPS |
TGLYDNLEKY |
HLPYPEAIFE |
ISYFKKHPEP |
FFALAKELYP |
GQFKPTICHY |
FMRLLKDKGL |
|
161 |
LLRCYTQNID |
TLERIAGLEQ |
EDLVEAHGTF |
YTSHCVSASC |
RHEYPLSWMK |
EKIFSEVTPK |
CEDCQSLVKP |
DIVFFGESLP |
|
241 |
ARFFSCMQSD |
FLKVDLLLVM |
GTSLQVQPFA |
SLISKAPLST |
PRLLINKEKA |
GQSDPFLGMI |
MGLGGGMDFD |
SKKAYRDVAW |
|
321 |
LGECDQGCLA |
LAELLGWKKE |
LEDLVRREHA |
SIDAQSGAGV |
PNPSTSASPK |
KSPPPAKDEA |
RTTEREKPQ |
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>sp|Q8IXJ6|SIRT2_human NAD-dependent deacetylase sirtuin-2
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVI
CLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGL
LLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAW
LGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
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