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(GAPDH) glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	6607
Official symbol	GAPDH
Official name	glyceraldehyde-3-phosphate dehydrogenase
Gene type	gene with protein product
Organism	Homo sapiens
Location	Chromosome 12 (NC_000012.11) : 6643656...6647535 (+)
Map	12p13.31
Length	3880 nt

Alternative name(s) and Synynom(s)

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Synonyms	MGC88685; G3PD; GAPD
Alternative name(s)	glyceraldehyde 3-phosphate dehydrogenase; aging-associated gene 9 protein

External Links

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EC_number	1.2.1.12
Ensembl	ENSG00000111640
Entrez	2597
HGNC	4141
HPRD	00713

Comment

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Summary	The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. [provided by RefSeq].

Bibliography

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Related Articles in PubMed

Genomic Context

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Go to ensembl

Sequence

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	FASTA

1	TAAATTGAGC	CCGCAGCCTC	CCGCTTCGCT	CTCTGCTCCT	CCTGTTCGAC	AGTCAGCCGC	ATCTTCTTTT	GCGTCGCCAG
81	GTGAAGACGG	GCGGAGAGAA	ACCCGGGAGG	CTAGGGACGG	CCTGAAGGCG	GCAGGGGCGG	GCGCAGGCCG	GATGTGTTCG
161	CGCCGCTGCG	GGGTGGGCCC	GGGCGGCCTC	CGCATTGCAG	GGGCGGGCGG	AGGACGTGAT	GCGGCGCGGG	CTGGGCATGG
241	AGGCCTGGTG	GGGGAGGGGA	GGGGAGGCGT	GTGTGTCGGC	CGGGGCCACT	AGGCGCTCAC	TGTTCTCTCC	CTCCGCGCAG
321	CCGAGCCACA	TCGCTCAGAC	ACCATGGGGA	AGGTGAAGGT	CGGAGTCAAC	GGGTGAGTTC	GCGGGTGGCT	GGGGGGCCCT
401	GGGCTGCGAC	CGCCCCCGAA	CCGCGTCTAC	GAGCCTTGCG	GGCTCCGGGT	CTTTGCAGTC	GTATGGGGGC	AGGGTAGCTG
481	TTCCCCGCAA	GGAGAGCTCA	AGGTCAGCGC	TCGGACCTGG	CGGAGCCCCG	CACCCAGGCT	GTGGCGCCCT	GTGCAGCTCC
561	GCCCTTGCGG	CGCCATCTGC	CCGGAGCCTC	CTTCCCCTAG	TCCCCAGAAA	CAGGAGGTCC	CTACTCCCGC	CCGAGATCCC
641	GACCCGGACC	CCTAGGTGGG	GGACGCTTTC	TTTCCTTTCG	CGCTCTGCGG	GGTCACGTGT	CGCAGAGGAG	CCCCTCCCCC
721	ACGGCCTCCG	GCACCGCAGG	CCCCGGGATG	CTAGTGCGCA	GCGGGTGCAT	CCCTGTCCGG	ATGCTGCGCC	TGCGGTAGAG
801	CGGCCGCCAT	GTTGCAACCG	GGAAGGAAAT	GAATGGGCAG	CCGTTAGGAA	AGCCTGCCGG	TGACTAACCC	TGCGCTCCTG
881	CCTCGATGGG	TGGAGTCGCG	TGTGGCGGGG	AAGTCAGGTG	GAGCGAGGCT	AGCTGGCCCG	ATTTCTCCTC	CGGGTGATGC
961	TTTTCCTAGA	TTATTCTCTG	GTAAATCAAA	GAAGTGGGTT	TATGGAGGTC	CTCTTGTGTC	CCCTCCCCGC	AGAGGTGTGG
1041	TGGCTGTGGC	ATGGTGCCAA	GCCGGGAGAA	GCTGAGTCAT	GGGTAGTTGG	AAAAGGACAT	TTCCACCGCA	AAATGGCCCC
1121	TCTGGTGGTG	GCCCCTTCCT	GCAGCGCCGG	CTCACCTCAC	GGCCCCGCCC	TTCCCCTGCC	AGCCTAGCGT	TGACCCGACC
1201	CCAAAGGCCA	GGCTGTAAAT	GTCACCGGGA	GGATTGGGTG	TCTGGGCGCC	TCGGGGAACC	TGCCCTTCTC	CCCATTCCGT
1281	CTTCCGGAAA	CCAGATCTCC	CACCGCACCC	TGGTCTGAGG	TTAAATATAG	CTGCTGACCT	TTCTGTAGCT	GGGGGCCTGG
1361	GCTGGGGCTC	TCTCCCATCC	CTTCTCCCCA	CACACATGCA	CTTACCTGTG	CTCCCACTCC	TGATTTCTGG	AAAAGAGCTA
1441	GGAAGGACAG	GCAACTTGGC	AAATCAAAGC	CCTGGGACTA	GGGGGTTAAA	ATACAGCTTC	CCCTCTTCCC	ACCCGCCCCA
1521	GTCTCTGTCC	CTTTTGTAGG	AGGGACTTAG	AGAAGGGGTG	GGCTTGCCCT	GTCCAGTTAA	TTTCTGACCT	TTACTCCTGC
1601	CCTTTGAGTT	TGATGATGCT	GAGTGTACAA	GCGTTTTCTC	CCTAAAGGGT	GCAGCTGAGC	TAGGCAGCAG	CAAGCATTCC
1681	TGGGGTGGCA	TAGTGGGGTG	GTGAATACCA	TGTACAAAGC	TTGTGCCCAG	ACTGTGGGTG	GCAGTGCCCC	ACATGGCCGC
1761	TTCTCCTGGA	AGGGCTTCGT	ATGACTGGGG	GTGTTGGGCA	GCCCTGGAGC	CTTCAGTTGC	AGCCATGCCT	TAAGCCAGGC
1841	CAGCCTGGCA	GGGAAGCTCA	AGGGAGATAA	AATTCAACCT	CTTGGGCCCT	CCTGGGGGTA	AGGAGATGCT	GCATTCGCCC
1921	TCTTAATGGG	GAGGTGGCCT	AGGGCTGCTC	ACATATTCTG	GAGGAGCCTC	CCCTCCTCAT	GCCTTCTTGC	CTCTTGTCTC
2001	TTAGATTTGG	TCGTATTGGG	CGCCTGGTCA	CCAGGGCTGC	TTTTAACTCT	GGTAAAGTGG	ATATTGTTGC	CATCAATGAC
2081	CCCTTCATTG	ACCTCAACTA	CATGGTGAGT	GCTACATGGT	GAGCCCCAAA	GCTGGTGTGG	GAGGAGCCAC	CTGGCTGATG
2161	GGCAGCCCCT	TCATACCCTC	ACGTATTCCC	CCAGGTTTAC	ATGTTCCAAT	ATGATTCCAC	CCATGGCAAA	TTCCATGGCA
2241	CCGTCAAGGC	TGAGAACGGG	AAGCTTGTCA	TCAATGGAAA	TCCCATCACC	ATCTTCCAGG	AGTGAGTGGA	AGACAGAATG
2321	GAAGAAATGT	GCTTTGGGGA	GGCAACTAGG	ATGGTGTGGC	TCCCTTGGGT	ATATGGTAAC	CTTGTGTCCC	TCAATATGGT
2401	CCTGTCCCCA	TCTCCCCCCC	ACCCCCATAG	GCGAGATCCC	TCCAAAATCA	AGTGGGGCGA	TGCTGGCGCT	GAGTACGTCG
2481	TGGAGTCCAC	TGGCGTCTTC	ACCACCATGG	AGAAGGCTGG	GGTGAGTGCA	GGAGGGCCCG	CGGGAGGGGA	AGCTGACTCA
2561	GCCCTGCAAA	GGCAGGACCC	GGGTTCATAA	CTGTCTGCTT	CTCTGCTGTA	GGCTCATTTG	CAGGGGGGAG	CCAAAAGGGT
2641	CATCATCTCT	GCCCCCTCTG	CTGATGCCCC	CATGTTCGTC	ATGGGTGTGA	ACCATGAGAA	GTATGACAAC	AGCCTCAAGA
2721	TCATCAGGTG	AGGAAGGCAG	GGCCCGTGGA	GAAGCGGCCA	GCCTGGCACC	CTATGGACAC	GCTCCCCTGA	CTTGCGCCCC
2801	GCTCCCTCTT	TCTTTGCAGC	AATGCCTCCT	GCACCACCAA	CTGCTTAGCA	CCCCTGGCCA	AGGTCATCCA	TGACAACTTT
2881	GGTATCGTGG	AAGGACTCAT	GGTATGAGAG	CTGGGGAATG	GGACTGAGGC	TCCCACCTTT	CTCATCCAAG	ACTGGCTCCT
2961	CCCTGCCGGG	GCTGCGTGCA	ACCCTGGGGT	TGGGGGTTCT	GGGGACTGGC	TTTCCCATAA	TTTCCTTTCA	AGGTGGGGAG
3041	GGAGGTAGAG	GGGTGATGTG	GGGAGTACGC	TGCAGGGCCT	CACTCCTTTT	GCAGACCACA	GTCCATGCCA	TCACTGCCAC
3121	CCAGAAGACT	GTGGATGGCC	CCTCCGGGAA	ACTGTGGCGT	GATGGCCGCG	GGGCTCTCCA	GAACATCATC	CCTGCCTCTA
3201	CTGGCGCTGC	CAAGGCTGTG	GGCAAGGTCA	TCCCTGAGCT	GAACGGGAAG	CTCACTGGCA	TGGCCTTCCG	TGTCCCCACT
3281	GCCAACGTGT	CAGTGGTGGA	CCTGACCTGC	CGTCTAGAAA	AACCTGCCAA	ATATGATGAC	ATCAAGAAGG	TGGTGAAGCA
3361	GGCGTCGGAG	GGCCCCCTCA	AGGGCATCCT	GGGCTACACT	GAGCACCAGG	TGGTCTCCTC	TGACTTCAAC	AGCGACACCC
3441	ACTCCTCCAC	CTTTGACGCT	GGGGCTGGCA	TTGCCCTCAA	CGACCACTTT	GTCAAGCTCA	TTTCCTGGTA	TGTGGCTGGG
3521	GCCAGAGACT	GGCTCTTAAA	AAGTGCAGGG	TCTGGCGCCC	TCTGGTGGCT	GGCTCAGAAA	AAGGGCCCTG	ACAACTCTTT
3601	TCATCTTCTA	GGTATGACAA	CGAATTTGGC	TACAGCAACA	GGGTGGTGGA	CCTCATGGCC	CACATGGCCT	CCAAGGAGTA
3681	AGACCCCTGG	ACCACCAGCC	CCAGCAAGAG	CACAAGAGGA	AGAGAGAGAC	CCTCACTGCT	GGGGAGTCCC	TGCCACACTC
3761	AGTCCCCCAC	CACACTGAAT	CTCCCCTCCT	CACAGTTGCC	ATGTAGACCC	CTTGAAGAGG	GGAGGGGCCT	AGGGAGCCGC
3841	ACCTTGTCAT	GTACCATCAA	TAAAGTACCC	TGTGCTCAAC

	>ref\|Gene_ID:2597\|GAPDH\|NC_000012.11:6643656...6647535 (+) TAAATTGAGCCCGCAGCCTCCCGCTTCGCTCTCTGCTCCTCCTGTTCGACAGTCAGCCGCATCTTCTTTTGCGTCGCCAG GTGAAGACGGGCGGAGAGAAACCCGGGAGGCTAGGGACGGCCTGAAGGCGGCAGGGGCGGGCGCAGGCCGGATGTGTTCG CGCCGCTGCGGGGTGGGCCCGGGCGGCCTCCGCATTGCAGGGGCGGGCGGAGGACGTGATGCGGCGCGGGCTGGGCATGG AGGCCTGGTGGGGGAGGGGAGGGGAGGCGTGTGTGTCGGCCGGGGCCACTAGGCGCTCACTGTTCTCTCCCTCCGCGCAG CCGAGCCACATCGCTCAGACACCATGGGGAAGGTGAAGGTCGGAGTCAACGGGTGAGTTCGCGGGTGGCTGGGGGGCCCT GGGCTGCGACCGCCCCCGAACCGCGTCTACGAGCCTTGCGGGCTCCGGGTCTTTGCAGTCGTATGGGGGCAGGGTAGCTG TTCCCCGCAAGGAGAGCTCAAGGTCAGCGCTCGGACCTGGCGGAGCCCCGCACCCAGGCTGTGGCGCCCTGTGCAGCTCC GCCCTTGCGGCGCCATCTGCCCGGAGCCTCCTTCCCCTAGTCCCCAGAAACAGGAGGTCCCTACTCCCGCCCGAGATCCC GACCCGGACCCCTAGGTGGGGGACGCTTTCTTTCCTTTCGCGCTCTGCGGGGTCACGTGTCGCAGAGGAGCCCCTCCCCC ACGGCCTCCGGCACCGCAGGCCCCGGGATGCTAGTGCGCAGCGGGTGCATCCCTGTCCGGATGCTGCGCCTGCGGTAGAG CGGCCGCCATGTTGCAACCGGGAAGGAAATGAATGGGCAGCCGTTAGGAAAGCCTGCCGGTGACTAACCCTGCGCTCCTG CCTCGATGGGTGGAGTCGCGTGTGGCGGGGAAGTCAGGTGGAGCGAGGCTAGCTGGCCCGATTTCTCCTCCGGGTGATGC TTTTCCTAGATTATTCTCTGGTAAATCAAAGAAGTGGGTTTATGGAGGTCCTCTTGTGTCCCCTCCCCGCAGAGGTGTGG TGGCTGTGGCATGGTGCCAAGCCGGGAGAAGCTGAGTCATGGGTAGTTGGAAAAGGACATTTCCACCGCAAAATGGCCCC TCTGGTGGTGGCCCCTTCCTGCAGCGCCGGCTCACCTCACGGCCCCGCCCTTCCCCTGCCAGCCTAGCGTTGACCCGACC CCAAAGGCCAGGCTGTAAATGTCACCGGGAGGATTGGGTGTCTGGGCGCCTCGGGGAACCTGCCCTTCTCCCCATTCCGT CTTCCGGAAACCAGATCTCCCACCGCACCCTGGTCTGAGGTTAAATATAGCTGCTGACCTTTCTGTAGCTGGGGGCCTGG GCTGGGGCTCTCTCCCATCCCTTCTCCCCACACACATGCACTTACCTGTGCTCCCACTCCTGATTTCTGGAAAAGAGCTA GGAAGGACAGGCAACTTGGCAAATCAAAGCCCTGGGACTAGGGGGTTAAAATACAGCTTCCCCTCTTCCCACCCGCCCCA GTCTCTGTCCCTTTTGTAGGAGGGACTTAGAGAAGGGGTGGGCTTGCCCTGTCCAGTTAATTTCTGACCTTTACTCCTGC CCTTTGAGTTTGATGATGCTGAGTGTACAAGCGTTTTCTCCCTAAAGGGTGCAGCTGAGCTAGGCAGCAGCAAGCATTCC TGGGGTGGCATAGTGGGGTGGTGAATACCATGTACAAAGCTTGTGCCCAGACTGTGGGTGGCAGTGCCCCACATGGCCGC TTCTCCTGGAAGGGCTTCGTATGACTGGGGGTGTTGGGCAGCCCTGGAGCCTTCAGTTGCAGCCATGCCTTAAGCCAGGC CAGCCTGGCAGGGAAGCTCAAGGGAGATAAAATTCAACCTCTTGGGCCCTCCTGGGGGTAAGGAGATGCTGCATTCGCCC TCTTAATGGGGAGGTGGCCTAGGGCTGCTCACATATTCTGGAGGAGCCTCCCCTCCTCATGCCTTCTTGCCTCTTGTCTC TTAGATTTGGTCGTATTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGAC CCCTTCATTGACCTCAACTACATGGTGAGTGCTACATGGTGAGCCCCAAAGCTGGTGTGGGAGGAGCCACCTGGCTGATG GGCAGCCCCTTCATACCCTCACGTATTCCCCCAGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCA CCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGTGAGTGGAAGACAGAATG GAAGAAATGTGCTTTGGGGAGGCAACTAGGATGGTGTGGCTCCCTTGGGTATATGGTAACCTTGTGTCCCTCAATATGGT CCTGTCCCCATCTCCCCCCCACCCCCATAGGCGAGATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCG TGGAGTCCACTGGCGTCTTCACCACCATGGAGAAGGCTGGGGTGAGTGCAGGAGGGCCCGCGGGAGGGGAAGCTGACTCA GCCCTGCAAAGGCAGGACCCGGGTTCATAACTGTCTGCTTCTCTGCTGTAGGCTCATTTGCAGGGGGGAGCCAAAAGGGT CATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTATGACAACAGCCTCAAGA TCATCAGGTGAGGAAGGCAGGGCCCGTGGAGAAGCGGCCAGCCTGGCACCCTATGGACACGCTCCCCTGACTTGCGCCCC GCTCCCTCTTTCTTTGCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTT GGTATCGTGGAAGGACTCATGGTATGAGAGCTGGGGAATGGGACTGAGGCTCCCACCTTTCTCATCCAAGACTGGCTCCT CCCTGCCGGGGCTGCGTGCAACCCTGGGGTTGGGGGTTCTGGGGACTGGCTTTCCCATAATTTCCTTTCAAGGTGGGGAG GGAGGTAGAGGGGTGATGTGGGGAGTACGCTGCAGGGCCTCACTCCTTTTGCAGACCACAGTCCATGCCATCACTGCCAC CCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGCTCTCCAGAACATCATCCCTGCCTCTA CTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACT GCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAGGTGGTGAAGCA GGCGTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGTCTCCTCTGACTTCAACAGCGACACCC ACTCCTCCACCTTTGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGTGGCTGGG GCCAGAGACTGGCTCTTAAAAAGTGCAGGGTCTGGCGCCCTCTGGTGGCTGGCTCAGAAAAAGGGCCCTGACAACTCTTT TCATCTTCTAGGTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTA AGACCCCTGGACCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACACTC AGTCCCCCACCACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGCCGC ACCTTGTCATGTACCATCAATAAAGTACCCTGTGCTCAAC

GAPDH, mRNA isoform 1 - Generality

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Primary source

RefSeq : NM_002046.3 (GI:83641890)

Name

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Type of transcript

mRNA

Organism

Homo sapiens

Length

1310 nt

Map

12p13

Location

Chromosome 12 (NC_000012.11) strand : +

6643656...6643734	6643975...6644026	6645659...6645758	6645849...6645955
6646085...6646175	6646266...6646381	6646474...6646555	6646749...6647161
6647266...6647535

Exon(s)

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Exon(s)	Start	End	Length	is coding
Exon 1	1	79	79	1
Exon 2	80	131	52	1
Exon 3	132	231	100	1
Exon 4	232	338	107	1
Exon 5	339	429	91	1
Exon 6	430	545	116	1
Exon 7	546	627	82	1
Exon 8	628	1040	413	1
Exon 9	1041	1310	270	1

Variation(s)

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ID	Class	Location	Mutation	Length	is synonymous	Source
rs45571036	SNP	21	c/t	1	?	dbSNP
rs45508900	SNP	23	c/t	1	?	dbSNP
rs11549339	SNP	42	g/t	1	?	dbSNP
rs45568532	SNP	47	a/g	1	?	dbSNP
rs11549368	SNP	53	c/t	1	?	dbSNP
rs3199979	SNP	64	c/t	1	?	dbSNP
rs11549332	SNP	65	c/t	1	?	dbSNP
rs11267039	SNP	75	a/g	1	?	dbSNP
rs35318117	SNP	84	g/t	1	?	dbSNP
rs1136666	SNP	95	c/g	1	?	dbSNP
rs11552253	SNP	95	c/g	1	?	dbSNP
rs11549335	SNP	108	g/t	1	?	dbSNP
rs11549357	SNP	112	a/g	1	?	dbSNP
rs11549359	SNP	159	a/c	1	?	dbSNP
rs45541435	SNP	167	c/g	1	?	dbSNP
rs11549361	SNP	188	a/g	1	?	dbSNP
rs11549342	SNP	189	g/t	1	?	dbSNP
rs11549369	SNP	208	c/g	1	?	dbSNP
rs11549328	SNP	217	g/t	1	?	dbSNP
rs875654	SNP	261	c/t	1	?	dbSNP
rs11549351	SNP	280	g/t	1	?	dbSNP
rs11549346	SNP	291	g/t	1	?	dbSNP
rs11549355	SNP	297	g/t	1	?	dbSNP
rs11549354	SNP	305	c/t	1	?	dbSNP
rs11549358	SNP	311	a/t	1	?	dbSNP
rs11549365	SNP	315	a/g	1	?	dbSNP
rs11549367	SNP	320	a/c	1	?	dbSNP
rs11549370	SNP	325	a/g	1	?	dbSNP
rs11549362	SNP	327	a/c	1	?	dbSNP
rs11266264	SNP	348	a/c	1	?	dbSNP
rs11549356	SNP	350	c/t	1	?	dbSNP
rs1803620	SNP	351	c/t	1	?	dbSNP
rs11549353	SNP	366	c/t	1	?	dbSNP
rs11549360	SNP	375	c/g	1	?	dbSNP
rs11549324	SNP	384	c/t	1	?	dbSNP
rs11549329	SNP	398	c/t	1	?	dbSNP
rs11549337	SNP	405	c/t	1	?	dbSNP
rs11549363	SNP	408	c/t	1	?	dbSNP
rs11266742	SNP	411	a/c	1	?	dbSNP
rs11549374	SNP	420	a/g	1	?	dbSNP
rs11549323	SNP	430	c/g	1	?	dbSNP
rs11549350	SNP	432	c/t	1	?	dbSNP
rs11549322	SNP	435	a/t	1	?	dbSNP
rs11549340	SNP	446	c/g	1	?	dbSNP
rs11549364	SNP	446	g/t	1	?	dbSNP
rs11549349	SNP	450	a/c	1	?	dbSNP
rs11549327	SNP	464	c/t	1	?	dbSNP
rs11549338	SNP	476	c/t	1	?	dbSNP
rs1065691	SNP	483	c/t	1	?	dbSNP
rs73047116	SNP	497	c/t	1	?	dbSNP
rs11549336	SNP	498	c/t	1	?	dbSNP
rs7392258	SNP	543	c/t	1	?	dbSNP
rs11549333	SNP	560	c/t	1	?	dbSNP
rs11549366	SNP	582	a/g	1	?	dbSNP
rs11549330	SNP	603	c/t	1	?	dbSNP
rs11549326	SNP	604	c/t	1	?	dbSNP
rs11549343	SNP	624	c/t	1	?	dbSNP
rs11549348	SNP	698	c/g	1	?	dbSNP
rs11549352	SNP	706	c/g	1	?	dbSNP
rs11549345	SNP	730	c/t	1	?	dbSNP
rs74098821	SNP	771	a/g	1	?	dbSNP
rs11549347	SNP	798	c/t	1	?	dbSNP
rs11549373	SNP	810	a/c	1	?	dbSNP
rs1062429	SNP	855	a/c	1	?	dbSNP
rs13154044	SNP	887	g/t	1	?	dbSNP
rs34467921	SNP	889	a/g	1	?	dbSNP
rs71576830	SNP	889	ggg/tga	3	?	dbSNP
rs11549316	SNP	899	c/t	1	?	dbSNP
rs1065740	SNP	905	c/g	1	?	dbSNP
rs1803623	SNP	909	c/t	1	?	dbSNP
rs1062436	SNP	910	c/t	1	?	dbSNP
rs3203507	SNP	922	c/t	1	?	dbSNP
rs1062442	SNP	930	a/c	1	?	dbSNP
rs1803619	SNP	955	g/t	1	?	dbSNP
rs1803625	SNP	983	c/t	1	?	dbSNP
rs1803621	SNP	987	c/t	1	?	dbSNP
rs11549325	SNP	990	c/t	1	?	dbSNP
rs11549334	SNP	1029	g/t	1	?	dbSNP
rs1109	SNP	1050	c/t	1	?	dbSNP
rs11549321	SNP	1067	a/t	1	?	dbSNP
rs1803624	SNP	1075	a/g	1	?	dbSNP
rs3211600	SNP	1086	g/t	1	?	dbSNP
rs11549371	SNP	1098	c/t	1	?	dbSNP
rs3211592	SNP	1116	c/t	1	?	dbSNP
rs11549320	SNP	1124	c/t	1	?	dbSNP
rs11552252	SNP	1189	a/c	1	?	dbSNP
rs11549315	SNP	1195	c/t	1	?	dbSNP
rs11549319	SNP	1204	c/t	1	?	dbSNP
rs1803622	SNP	1227	g/t	1	?	dbSNP
rs3211598	SNP	1246	a/g	1	?	dbSNP
rs3211599	SNP	1270	a/c	1	?	dbSNP
rs11549318	SNP	1277	c/t	1	?	dbSNP

CDS

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Primary source

NCBI : CCDS8549

Nucleotide

GAPDH, mRNA isoform 1[NM_002046.3] : 103...1110

Length

1008

Location

Chromosome 12 (NC_000012.11) strand : +

6643998...6644026	6645659...6645758	6645849...6645955	6646085...6646175
6646266...6646381	6646474...6646555	6646749...6647161	6647266...6647335

Start codon

Translation

NP_002037.2

Sequence

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	FASTA

1	AAATTGAGCC	CGCAGCCTCC	CGCTTCGCTC	TCTGCTCCTC	CTGTTCGACA	GTCAGCCGCA	TCTTCTTTTG	CGTCGCCAGC
81	CGAGCCACAT	CGCTCAGACA	CCATGGGGAA	GGTGAAGGTC	GGAGTCAACG	GATTTGGTCG	TATTGGGCGC	CTGGTCACCA
161	GGGCTGCTTT	TAACTCTGGT	AAAGTGGATA	TTGTTGCCAT	CAATGACCCC	TTCATTGACC	TCAACTACAT	GGTTTACATG
241	TTCCAATATG	ATTCCACCCA	TGGCAAATTC	CATGGCACCG	TCAAGGCTGA	GAACGGGAAG	CTTGTCATCA	ATGGAAATCC
321	CATCACCATC	TTCCAGGAGC	GAGATCCCTC	CAAAATCAAG	TGGGGCGATG	CTGGCGCTGA	GTACGTCGTG	GAGTCCACTG
401	GCGTCTTCAC	CACCATGGAG	AAGGCTGGGG	CTCATTTGCA	GGGGGGAGCC	AAAAGGGTCA	TCATCTCTGC	CCCCTCTGCT
481	GATGCCCCCA	TGTTCGTCAT	GGGTGTGAAC	CATGAGAAGT	ATGACAACAG	CCTCAAGATC	ATCAGCAATG	CCTCCTGCAC
561	CACCAACTGC	TTAGCACCCC	TGGCCAAGGT	CATCCATGAC	AACTTTGGTA	TCGTGGAAGG	ACTCATGACC	ACAGTCCATG
641	CCATCACTGC	CACCCAGAAG	ACTGTGGATG	GCCCCTCCGG	GAAACTGTGG	CGTGATGGCC	GCGGGGCTCT	CCAGAACATC
721	ATCCCTGCCT	CTACTGGCGC	TGCCAAGGCT	GTGGGCAAGG	TCATCCCTGA	GCTGAACGGG	AAGCTCACTG	GCATGGCCTT
801	CCGTGTCCCC	ACTGCCAACG	TGTCAGTGGT	GGACCTGACC	TGCCGTCTAG	AAAAACCTGC	CAAATATGAT	GACATCAAGA
881	AGGTGGTGAA	GCAGGCGTCG	GAGGGCCCCC	TCAAGGGCAT	CCTGGGCTAC	ACTGAGCACC	AGGTGGTCTC	CTCTGACTTC
961	AACAGCGACA	CCCACTCCTC	CACCTTTGAC	GCTGGGGCTG	GCATTGCCCT	CAACGACCAC	TTTGTCAAGC	TCATTTCCTG
1041	GTATGACAAC	GAATTTGGCT	ACAGCAACAG	GGTGGTGGAC	CTCATGGCCC	ACATGGCCTC	CAAGGAGTAA	GACCCCTGGA
1121	CCACCAGCCC	CAGCAAGAGC	ACAAGAGGAA	GAGAGAGACC	CTCACTGCTG	GGGAGTCCCT	GCCACACTCA	GTCCCCCACC
1201	ACACTGAATC	TCCCCTCCTC	ACAGTTGCCA	TGTAGACCCC	TTGAAGAGGG	GAGGGGCCTA	GGGAGCCGCA	CCTTGTCATG
1281	TACCATCAAT	AAAGTACCCT	GTGCTCAACC

GAPDH - Exon 1

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Exon number	1
Length	79 nt
Location	Chromosome 12 (NC_000012.11) : 6643656...6643734 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	AAATTGAGCCCGCAGCCTCCCGCTTCGCTCTCTGCTCCTCCTGTTCGACAGTCAGCCGCATCTTCTTTTGCGTCGCCAG

GAPDH - Exon 2

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Exon number	2
Length	52 nt
Location	Chromosome 12 (NC_000012.11) : 6643975...6644026 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	CCGAGCCACATCGCTCAGACACCATGGGGAAGGTGAAGGTCGGAGTCAACGG

GAPDH - Exon 3

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Exon number	3
Length	100 nt
Location	Chromosome 12 (NC_000012.11) : 6645659...6645758 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	ATTTGGTCGTATTGGGCGCCTGGTCACCAGGGCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCT TCATTGACCTCAACTACATG

GAPDH - Exon 4

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Exon number	4
Length	107 nt
Location	Chromosome 12 (NC_000012.11) : 6645849...6645955 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	GTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTCAAGGCTGAGAACGGGAAGCTTGTCATCAA TGGAAATCCCATCACCATCTTCCAGGA

GAPDH - Exon 5

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Exon number	5
Length	91 nt
Location	Chromosome 12 (NC_000012.11) : 6646085...6646175 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	GCGAGATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGCGTCTTCACCACCATGG AGAAGGCTGGG

GAPDH - Exon 6

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Exon number	6
Length	116 nt
Location	Chromosome 12 (NC_000012.11) : 6646266...6646381 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	GCTCATTTGCAGGGGGGAGCCAAAAGGGTCATCATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAA CCATGAGAAGTATGACAACAGCCTCAAGATCATCAG

GAPDH - Exon 7

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Exon number	7
Length	82 nt
Location	Chromosome 12 (NC_000012.11) : 6646474...6646555 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	CAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTGGCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCA TG

GAPDH - Exon 8

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Exon number	8
Length	413 nt
Location	Chromosome 12 (NC_000012.11) : 6646749...6647161 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	ACCACAGTCCATGCCATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGCGGGGC TCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTCATCCCTGAGCTGAACGGGAAGCTCA CTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTGTCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATAT GATGACATCAAGAAGGTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAGGGCATCCTGGGCTACACTGAGCACCAGGTGGT CTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGCATTGCCCTCAACGACCACTTTGTCA AGCTCATTTCCTG

GAPDH - Exon 9

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Exon number	9
Length	270 nt
Location	Chromosome 12 (NC_000012.11) : 6647266...6647535 (+)
Is part of	GAPDH, mRNA isoform 1 (NM_002046.3)
Sequence	Show
	GTATGACAACGAATTTGGCTACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAAGACCCCTGGA CCACCAGCCCCAGCAAGAGCACAAGAGGAAGAGAGAGACCCTCACTGCTGGGGAGTCCCTGCCACACTCAGTCCCCCACC ACACTGAATCTCCCCTCCTCACAGTTGCCATGTAGACCCCTTGAAGAGGGGAGGGGCCTAGGGAGCCGCACCTTGTCATG TACCATCAATAAAGTACCCTGTGCTCAACC

P04406 - Generality

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Primary source	Uniprot : P04406
Name	Glyceraldehyde-3-phosphate dehydrogenase
Alternative name(s)
Synonym(s)	GAPDH
Organism	Homo sapiens
Length	335 aa
Protein existence	---

External Links

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ArrayExpress	P04406
BRENDA	1.2.1.12
Prints	PR00078
Smart	SM00846
Refseq	NP_002037.2
Uniprot	P04406
EBI	EBI-354056
InterPro	IPR006424 IPR000173 IPR020828 IPR020831 IPR020832 IPR020829 IPR020830
KEGG	hsa:2597
PDB	3GPD 2FEH 1ZNQ 1U8F
PDBsum	3GPD 2FEH 1ZNQ 1U8F
PROSITE	PS00071
Pfam	PF00044 PF02800

General annotation (Comments)

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Catalytic activity	D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
Function	Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5.
Ptm	Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation, which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis (By similarity).
Similarity	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Subcellular location	Cytoplasm. Cytoplasm, perinuclear region. Membrane. Note=Postnuclear and Perinuclear regions.
Subunit	Homotetramer. Interacts with TPPP; the interaction is direct (By similarity). Interacts with EIF1AD, PRKCI and WARS.

Ontologies

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Biological process	glycolysis [GO:0006096] oxidation reduction [GO:0055114]
Cellular component	membrane [GO:0016020] perinuclear region of cytoplasm [GO:0048471]
Molecular function	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity [GO:0004365] protein binding [GO:0005515] NAD or NADH binding [GO:0051287]

Binary interactions

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With	Uniprot accession	IntAct
MK01	P28482	EBI-354056,EBI-959949
-	Q65ZQ1	EBI-354056,EBI-1054063
MDM2	Q00987	EBI-354056,EBI-389668
TXN	Q5T937	EBI-354056,
BTBD2	Q9BX70	EBI-354056,EBI-710091
RPA2	P15927	EBI-354056,EBI-621404
QRICH2	Q9H0J4	EBI-354056,EBI-1053637
KAT5	Q92993	EBI-354056,EBI-399080

Alternative product(s)

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Sequence annotation

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Feature key	Position	Length	Description	Feature identifier
Molecule processing
Initiator methionine	1 - 1	1	Removed	P04406-INIT_MET-1
Region
Nucleotide binding	13 - 14	2	NAD	P04406-NP_BIND-13
Region	2 - 148	147	Interaction with WARS	P04406-REGION-2
Region	151 - 153	3	Glyceraldehyde 3-phosphate binding (By similarity)	P04406-REGION-151
Region	211 - 212	2	Glyceraldehyde 3-phosphate binding (By similarity)	P04406-REGION-211
Sites
Active site	152 - 152	1	Nucleophile	P04406-ACT_SITE-152
Binding site	35 - 35	1	NAD	P04406-BINDING-35
Binding site	80 - 80	1	NAD; via carbonyl oxygen	P04406-BINDING-80
Binding site	122 - 122	1	NAD	P04406-BINDING-122
Binding site	182 - 182	1	Glyceraldehyde 3-phosphate (By similarity)	P04406-BINDING-182
Binding site	234 - 234	1	Glyceraldehyde 3-phosphate (By similarity)	P04406-BINDING-234
Binding site	316 - 316	1	NAD	P04406-BINDING-316
Site	2 - 2	1	Not acetylated	P04406-SITE-2
Site	179 - 179	1	Activates thiol group during catalysis	P04406-SITE-179
Natural variations
Natural variant site	22 - 22	1	A -> G (in dbSNP:rs45541435)	VAR_018889
Natural variant site	251 - 251	1	K -> N (in dbSNP:rs1062429)	VAR_049218
Amino acid modifications
Modified residue	5 - 5	1	N6,N6-dimethyllysine	P04406-MOD_RES-5
Modified residue	9 - 9	1	Deamidated asparagine	P04406-MOD_RES-9
Modified residue	42 - 42	1	Phosphotyrosine	P04406-MOD_RES-42
Modified residue	61 - 61	1	N6-acetyllysine	P04406-MOD_RES-61
Modified residue	64 - 64	1	Deamidated asparagine	P04406-MOD_RES-64
Modified residue	66 - 66	1	N6,N6-dimethyllysine	P04406-MOD_RES-66
Modified residue	70 - 70	1	Deamidated asparagine	P04406-MOD_RES-70
Modified residue	75 - 75	1	Phosphothreonine	P04406-MOD_RES-75
Modified residue	83 - 83	1	Phosphoserine	P04406-MOD_RES-83
Modified residue	122 - 122	1	Phosphoserine	P04406-MOD_RES-122
Modified residue	148 - 148	1	Phosphoserine	P04406-MOD_RES-148
Modified residue	149 - 149	1	Deamidated asparagine	P04406-MOD_RES-149
Modified residue	151 - 151	1	Phosphoserine	P04406-MOD_RES-151
Modified residue	152 - 152	1	S-nitrosocysteine; in reversibly inhibited form (By similarity)	P04406-MOD_RES-152
Modified residue	154 - 154	1	Phosphothreonine	P04406-MOD_RES-154
Modified residue	155 - 155	1	Deamidated asparagine	P04406-MOD_RES-155
Modified residue	184 - 184	1	Phosphothreonine	P04406-MOD_RES-184
Modified residue	186 - 186	1	N6-acetyllysine	P04406-MOD_RES-186
Modified residue	194 - 194	1	N6-acetyllysine	P04406-MOD_RES-194
Modified residue	210 - 210	1	Phosphoserine	P04406-MOD_RES-210
Modified residue	211 - 211	1	Phosphothreonine	P04406-MOD_RES-211
Modified residue	215 - 215	1	N6,N6-dimethyllysine	P04406-MOD_RES-215
Modified residue	219 - 219	1	N6-acetyllysine	P04406-MOD_RES-219
Modified residue	225 - 225	1	Deamidated asparagine	P04406-MOD_RES-225
Modified residue	227 - 227	1	N6-acetyllysine	P04406-MOD_RES-227
Modified residue	229 - 229	1	Phosphothreonine	P04406-MOD_RES-229
Modified residue	237 - 237	1	Phosphothreonine	P04406-MOD_RES-237
Modified residue	254 - 254	1	N6-acetyllysine	P04406-MOD_RES-254
Modified residue	260 - 260	1	N6,N6-dimethyllysine	P04406-MOD_RES-260
Modified residue	263 - 263	1	N6,N6-dimethyllysine	P04406-MOD_RES-263
Modified residue	312 - 312	1	Phosphoserine	P04406-MOD_RES-312
Modified residue	314 - 314	1	Phosphotyrosine (By similarity)	P04406-MOD_RES-314
Modified residue	316 - 316	1	Deamidated asparagine	P04406-MOD_RES-316
Modified residue	320 - 320	1	Phosphotyrosine	P04406-MOD_RES-320
Modified residue	334 - 334	1	N6,N6-dimethyllysine	P04406-MOD_RES-334

Sequence

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	FASTA

1	MGKVKVGVNG	FGRIGRLVTR	AAFNSGKVDI	VAINDPFIDL	NYMVYMFQYD	STHGKFHGTV	KAENGKLVIN	GNPITIFQER
81	DPSKIKWGDA	GAEYVVESTG	VFTTMEKAGA	HLQGGAKRVI	ISAPSADAPM	FVMGVNHEKY	DNSLKIISNA	SCTTNCLAPL
161	AKVIHDNFGI	VEGLMTTVHA	ITATQKTVDG	PSGKLWRDGR	GALQNIIPAS	TGAAKAVGKV	IPELNGKLTG	MAFRVPTANV
241	SVVDLTCRLE	KPAKYDDIKK	VVKQASEGPL	KGILGYTEHQ	VVSSDFNSDT	HSSTFDAGAG	IALNDHFVKL	ISWYDNEFGY
321	SNRVVDLMAH	MASKE