(HSPB8) heat shock 22kDa protein 8 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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6825
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Official symbol
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HSPB8
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Official name
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heat shock 22kDa protein 8
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 12 (NC_000012.11) : 119616594...119632550 (+)
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Map
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12q24.23
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Length
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15957 nt
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NM_014365.2
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HSPB8, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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Q9UJY1
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Heat shock protein beta-8
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Homo sapiens
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196 aa
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Synonyms |
HMN2A; HMN2; DHMN2; CMT2L; HspB8; HSP22; H11; E2IG1
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Alternative name(s) |
heat shock protein beta-8; E2-induced gene 1; small stress protein-like protein HSP22; protein kinase H11; heat shock 27kDa protein 8
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Summary |
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl
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1 |
CCCACAGCCC |
AGCTGTTCCC |
TCCGCGGATT |
CTCCGGGGCT |
GGTTCATCAC |
CTCCGAATAT |
TCCTGTGACA |
GGAGACGCTT |
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81 |
GCAAAACCCG |
CCTCCAGCCT |
CCAGCAGCAA |
ATAAATAGAA |
GGCTTGCAGC |
CCAGAAGGAG |
CCAGAAGAAG |
TTTCTAGGCG |
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161 |
CGCGTGCCCT |
GGGTTTATTA |
AGCTCCTGGC |
TCCGCTCTAG |
ACCTCAGCGG |
TTCTGGCTGC |
CAGCCTGGGC |
AGCCTGGGAA |
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241 |
GCCTGGGAGG |
ACGGTGGCTT |
GCCGGTCTGT |
CGTGAGGCAG |
TGCGGACGGG |
GACCCTCTGG |
GATTCTGCTG |
GATCTGCCCC |
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321 |
GGGGGTTACC |
TTTGGGGGCT |
GGGACCCCAG |
TCGAGGGGAC |
ACAACCGTCC |
CTGGCAGTGG |
TTGGTTCTGC |
TTCTCCCTGC |
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401 |
AGAAAAGCAG |
CATTTTCGGA |
AGCTGAAGAA |
TAAGCTAGCC |
CAGCCACACC |
ACCTTGTTGT |
GTGACCTTGG |
GCAGGTGGTT |
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481 |
CTGTCTCTCT |
GAGCCTCTGT |
TTCTCTCTGA |
GCTGAGCAGC |
CACCATGGCT |
GACGGTCAGA |
TGCCCTTCTC |
CTGCCACTAC |
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561 |
CCAAGCCGCC |
TGCGCCGAGA |
CCCCTTCCGG |
GACTCTCCCC |
TCTCCTCTCG |
CCTGCTGGAT |
GATGGCTTTG |
GCATGGACCC |
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641 |
CTTCCCAGAC |
GACTTGACAG |
CCTCTTGGCC |
CGACTGGGCT |
CTGCCTCGTC |
TCTCCTCCGC |
CTGGCCAGGC |
ACCCTAAGGT |
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721 |
CGGGCATGGT |
GCCCCGGGGC |
CCCACTGCCA |
CCGCCAGGTT |
TGGGGTGCCT |
GCCGAGGGCA |
GGACCCCCCC |
ACCCTTCCCT |
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801 |
GGGGAGCCCT |
GGAAAGTGTG |
TGTGAATGTG |
CACAGCTTCA |
AGCCAGAGGA |
GTTGATGGTG |
AAGACCAAAG |
ATGGATACGT |
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881 |
GGAGGTGTCT |
GGTAAGTCAG |
GGGCAGGAGG |
GAGAGAGAAT |
GGGGAGGCCG |
GGATGTAGCC |
CTCAGCCCTG |
GGAATAGCCA |
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961 |
GAGAAAGTTT |
CCTGGGAGCT |
GACGTTGGGA |
CAGTGTGACA |
CAGGTGACCT |
CAGGGCTCAG |
GAATGCAGCC |
TGCAAAGTTA |
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1041 |
TCTTTACGGA |
AAACTTCTCT |
CCCGGCTCCC |
AGCAGAGATC |
TTAACCTGCC |
TGACTCAGCT |
ATTGGGGCCT |
CTGGGTGCTC |
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1121 |
ATCAATCATG |
GTACAGACAG |
GAAAATAGAA |
ACCATGTTGG |
ATATTTTGAC |
AGAGGGCATT |
TAATATAAAG |
AATAGGTTAA |
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1201 |
GCAGATATCA |
AAGAATTAAA |
AAACAAAGAA |
GAAACGGGAT |
TTTGTGCACT |
CCAGCATCAT |
AACAGAGTCT |
AGAAGTGCAC |
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1281 |
GTTAAGGCTG |
AACAATGATA |
GTGTTAATAA |
CCGCAACTGG |
TTTCCGGTGA |
AACACCTCTC |
CTTGTCCCAG |
ACAGGGAAAC |
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1361 |
TGAGGCTTAC |
CAGTAATTGT |
AGTAACACTA |
ACTGGTAACT |
CTGAGTGCTA |
ACTATTCGCT |
CAGCACTTTG |
CTAACTGCTG |
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1441 |
TTGCCTATAA |
TATCTCAGCT |
AATACCACAA |
CCAGAGGAGG |
TGGGTACTGT |
TTATCTTCTT |
TTTTCAGATG |
AGGAAACTGA |
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1521 |
GGCACGGAGA |
GATTAAAGTA |
ACTTGTTCAA |
GGCCACCAAG |
GAGTCAGACC |
CAGGTTGTCT |
GGGAATTAGG |
AGGCCAGAAA |
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1601 |
GAAGAAGTGA |
TGATTTACTG |
AGCACCTACT |
AGGTGCCAAG |
GGTGGGCTGA |
CATTCTTATA |
CTTCTCCAAA |
ATCATCCTCA |
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1681 |
GTCCACTCCA |
GGGTAGCAGG |
GTAGGCCCAT |
CTTGCAGCTG |
AGGAGGCTGA |
GGCCTAGGTG |
GGACTCGTTC |
ACAGTCATGC |
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1761 |
CATGAGTCAG |
CAATAGGAGT |
GGAGTAGGGA |
CTGGGCCTAT |
GCACAGCTTT |
AGGCCCAGGG |
CTCTCACTGC |
CGCATCCCAC |
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1841 |
CCTGGGAGAA |
ATAAACATAC |
TAGGGGGAAA |
AATGAGAGAA |
GACAGGAAGC |
TCAGCCCCTG |
TGAAGCTGGG |
CAGTAGAAAA |
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1921 |
ATCTTTCTTT |
TCCTTCCCTC |
CTGATTAACA |
CTCCATTAAA |
AAGAATGTGT |
TCCCGGCAGA |
GGCTTGCCTT |
CCAGAAAATC |
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2001 |
AGTCAAAGCC |
ATTGCAAACA |
CAGGCTGGGC |
AGGAACAAGC |
CCCAGCAGCA |
TTCAGGGGGA |
GTTTCAAGCC |
AGTCCTGGTA |
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2081 |
GAATTATAAA |
CATCAGAGGC |
TCCAGCGGGT |
GTGGTGGGCT |
GGGAGACACG |
CTGGGGCCAC |
GTGCTGATGA |
CAGGGTCAGC |
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2161 |
CAGATTTCTG |
AGTTGGCTGG |
GGAGCAGGGC |
ATGAGTTCCG |
AAACTGGCTC |
CAACTTTAAC |
CAGCAGGATG |
TGCAAATTAC |
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2241 |
TTCACTTTGT |
GCTTCTGTTT |
TGTTTCCTCA |
TCTGGAAATT |
AGGGTTCAAA |
TGGTTATACC |
ATAAGGATTG |
TTGTTTTAAG |
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2321 |
TGAGGTGATG |
CTGTAAAATG |
TGTACATACC |
TGTGAACCCA |
GAAAATCTGA |
GACAGATCTC |
AGTTCATTTA |
GGAAGTTTAT |
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2401 |
TTTGCCGAGG |
TTGAGGACAC |
TCCCATGACA |
CAGCCTCAGG |
AAGTCCTCCT |
GTCACATGCC |
CAAGGTGGTC |
TGGGCACAGC |
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2481 |
TTAATTTTAT |
ACATTTTAGA |
GAGACATGAG |
ACATCAATCA |
ATATATGTAA |
GAAGTACATT |
GGTTCGATCT |
AGAAATGCAG |
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2561 |
GACAACTTGA |
AGCAGGGAGG |
GGTTTTCCAG |
GTCACAGGTA |
GGTGAGAGAC |
AAATGGTCGC |
ATTCTTTTGA |
GTTTCTGATT |
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2641 |
AGCCTTTCCA |
AAGGAGACAA |
ACAGATAATG |
CATCTATGTC |
AGTGAGCAGA |
GGGCTGCCTT |
TGAATAGAAT |
GGGGGGTAGG |
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2721 |
TTGGCCCTAA |
ACAGTTCCCA |
GCTTGACTTT |
TCCCTTTAGC |
TTAGTGATTT |
GGGGGCCCCA |
AGATTTATTT |
TCCTTTCACA |
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2801 |
TTCTATGACC |
TGGAACACAA |
GGAATTAGTA |
TTATTATTGT |
CGTCGTTATT |
GTTATAGTGT |
CAGGCATCCA |
GGAAGGCCCC |
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2881 |
AATAAATAAT |
GAATAATAGA |
TGCTCTTTGA |
AACCTGGGTT |
CAGATCCCAG |
CACTGCTGTT |
CACTAGCATG |
GCGGATGTGG |
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2961 |
ACGAGAAAGT |
CTTCATCCCT |
CTGAGCCTCA |
TTTCTCCTAT |
TTGCAGAATG |
GAGACCATAA |
TAATATCTGT |
CCTGTAAGGG |
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3041 |
TGTAGGAAAG |
ATTAAACATA |
TGCAGACTAT |
CTATGATAAT |
ATATGCGGAG |
TGTCTATAAA |
ATGGAGCTAA |
TAATAGTGCT |
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3121 |
TGCCTGGCAC |
TCTGTAAACA |
GACCGATTAT |
CACCATTCCT |
TCTGTCCTTG |
TTTTAATTAG |
GGTCTTAGAT |
GCTTCTAGCC |
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3201 |
CAAGTCCAAG |
GGTCGACTCC |
ACCCTGTGGT |
CCCTCTAGGA |
GACCCTCTGT |
CCAGCCTGGA |
GGGTTTTTCA |
CCATCCTCTT |
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3281 |
TTGTAGGTGC |
TTCATAACAG |
GTGGGGTCTG |
GCAGCTCCAT |
GTTGAGATCT |
CAGCTAAGTA |
TCTTACTAAT |
CCAGAGGCTT |
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3361 |
TGGGTGAGTC |
ATGCAGTCTC |
AATTTCCACG |
TCTGTAAAAT |
GGGGTCATTG |
GGAGCTTAAA |
TAAGACAAAG |
ACAAAGCTTT |
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3441 |
TCAGACATGC |
AATTAGTGAC |
ATCGGCTAGA |
CAAAATCCAA |
ATTCCCTGAG |
AGTCCATACA |
AGGGCTTTCA |
TAAAAGGGGT |
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3521 |
TTAAAAATAA |
AATTGATATC |
AGGAGCTCTA |
TTTAAGAAGC |
AACTTTCGGG |
CCGGGTGCGG |
TGGCTCATGC |
CTGTAATCCC |
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3601 |
AGCATTTTGG |
GAGGCCAAGG |
CGGGAGGATC |
GCTTAAGGTC |
AGGAGTCTGA |
GACCAGTCTG |
GTCAACATGG |
CGAAACCCCG |
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3681 |
TTCTACTAAA |
AATACAAAAA |
TTAGCCGGGT |
GTGGTGGTGA |
GCGCCTGTAA |
TCCCAGCTAC |
TCAGGAGTCT |
GAGGCAGGAG |
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3761 |
AATCGCTTGA |
ACCTGGGAGG |
TGGAGGTTGC |
AGTGAGCTGA |
GACCGTGCCA |
CTGCATTCCA |
GCCTGGGCAA |
CAAGAAAGAA |
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3841 |
ATTCTGTCTC |
AAAAAAAATA |
AAAAATAAAA |
ATAAATAAAA |
AGCAATTTTC |
AAGGGAAGTT |
GGAAGTCAGA |
TCCAGTTTCC |
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3921 |
CACCCTATAC |
CACAAAATGA |
CAAATCCGTT |
CCTCCACAAG |
CACGTGCTAA |
AGGCCTACAT |
GTGGTGGCTC |
AGTGGTTCCT |
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4001 |
CACAAGGACC |
TCCTAGGAAG |
TGTGGGTAGG |
TTTGTTAACC |
CCATTATACA |
GATAAGGAAG |
CCGAGGCCCA |
GAGAAAGTAA |
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4081 |
CTCACCTGAG |
ATTACCCACT |
TCTCCCTGGC |
AGTGTCTGAC |
ATTCAATGTC |
AGGCCTCTCT |
GGCTGGTTCT |
GAGTCAGGAT |
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4161 |
GGCTGGATCT |
ACTTCTGGCG |
GTGTGGCCCT |
GAGCAAATCC |
CACAGCCTCT |
GGAGCCTCAG |
TTTTACTGTT |
GGTCTTATGA |
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4241 |
AGAGGTAGAC |
AAGATCAGAA |
TTTACCAATG |
TACTTCAAGC |
TGTTACTAGG |
CATCTAGAAA |
CAGGAGCAGG |
AGAGTTCAAG |
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4321 |
GTCTTGTATG |
GTGCCAGTAA |
AAACAAAATT |
ATAAACAGGT |
CTTCTCACTG |
CAGGACTTAT |
CAGAGCCTTT |
AAGTCACTAA |
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4401 |
TGTAGTTTAT |
GAATCTCTAA |
GAGGCAGCCC |
TATCTTATCT |
GACCACGTAT |
GAGTGTCTCA |
TTCAAGGAAG |
TGTTTGGAAA |
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4481 |
ATGCTGGACT |
AGACAATTTC |
CAGCAAGCCT |
CAGATTCCCC |
TACCCCCATC |
CTGCAACCAC |
CAGCCAAGAA |
ATGTTCCCTT |
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4561 |
CATGGGCCAC |
TGGGCCAGAC |
CCTGGCTAAG |
ATAGAGACTG |
GAAAGCCCCA |
AGGCCTTATT |
TCCACCCCTT |
CTCCTTAGTC |
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4641 |
CCAGGGACTC |
TGCCTTCCCT |
GGAAACAGCA |
CTTTCTTTCT |
TTAGCTGGGC |
CAATAGTGTT |
CCACCTACAT |
TTCTCTGAGG |
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4721 |
CATGTTGAAA |
AAAGCATGTC |
TGCAAGGGGT |
TTCTGACTTC |
TCCTAGCCTC |
TGGATGTATT |
TCTAAAAATC |
ATAATAATTA |
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4801 |
CTTTTTTCAG |
TTTACAAAAA |
TAAAATGTCT |
TCATGATAAA |
ATATGTAGTT |
AGGAAAGCAA |
AATAAGAAAT |
TAAAAATCAC |
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4881 |
TCATAATCCT |
TAAGCTGCCC |
CAATCTAAGT |
AGGCAAATGA |
TAAGCAAATT |
GAGTTTCAAG |
ATGATCCTCC |
TAGCAACACT |
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4961 |
CTCTTTAAAT |
GAGGTTAACC |
CCACCTCCAG |
GCCCCTCTTT |
TGGAAATCTT |
GGAGCTTTCC |
CTGCTCAGAG |
ATCCTCCCTT |
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5041 |
CCCTCACCCC |
AATACCCTAT |
TTTCAGAGCA |
GACAGAGGCA |
CCTAGTTTCT |
GAGGAGCAGT |
CTTTTCCCCA |
AACATCAAAA |
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5121 |
TAAACCACAA |
GTGTTTACCT |
TCACATGGTA |
CTTTTACAAC |
TTCCAAAGCC |
ATTCTGTGAC |
TCGCTTTCAT |
TTGCTTCCTA |
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5201 |
CGGTAACCCG |
GTAAGATAGG |
TGTCGTCATT |
CCCATTTCAG |
AGAAGAATAA |
ACTGAGGCTC |
AGAGAAACTT |
AGAGATGTGC |
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5281 |
CAGGAAATGT |
CAGAGTAGAG |
ACTTAAGTCC |
AACACCCAAT |
ATTCCAGAAC |
CTGTCTGCCT |
GCTTTTGAAT |
CTTTGCACCA |
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5361 |
GTCACTTCCA |
AGCTGTGTGA |
CCTTGGATAC |
AGCACTTAAC |
CTCTCTGAAC |
TTCGGGTTTC |
CTATCTACAA |
AATGACAATA |
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5441 |
ATGAAAATGC |
CTGCTTATAT |
TATTATTTTA |
CTATTATTAT |
TTAAGGTTGT |
TGCAAAAATT |
AAAGGAGTTG |
ATACAGATAA |
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5521 |
GGTGCTTAGA |
ACAGTGGCTG |
ACACCAAGGA |
AGCGCTATAT |
TACTTGCTAT |
TATTATTTAT |
ATTATCAGTT |
TTTATTCCCA |
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5601 |
GGACACCAGC |
ATGCAGGAGG |
ATTCTAGGAT |
GCAAAAGGGC |
TGAGTCAGAG |
GCACTGGCCT |
GTCCCCAGGG |
GAAGCAGGTC |
|
5681 |
TCCCGGCGCC |
CTGGCTGTGG |
GGAGGGTACC |
AAAGAACAGA |
CAGTGCTCTT |
CTGGGCACAG |
GCCTGTGCTA |
GAGCCAGGCA |
|
5761 |
GTTGGTGGTC |
ATGGAGTTGG |
CAGCACAAGG |
TAGACTCTTT |
AAGCGGCCAC |
ACATTCACAG |
GATAGCATGT |
TCTGGTTAGC |
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5841 |
CAGACACTCC |
AGTTTAAAAT |
GAATTTCTTT |
TGCTGAGAGC |
AATTTAGGAA |
CATAGATTAA |
GCCTTAGAAA |
TTCTGGAAGT |
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5921 |
TGCATTAGTC |
CTCAGTTAAT |
CCTAAAGAAG |
TCATAGGGCG |
GCCTGGTGTG |
AGGTTCTAGC |
TACAAGAATG |
TTCAGGGCCA |
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6001 |
CGAAGTTCTC |
GCCAACGTTG |
GAAACTCTTC |
AGCACCCCAA |
AGTAGGGGAT |
TGGTTAAATT |
AGCTCTTATG |
TATTCCTCAA |
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6081 |
TAGAACACTG |
CAGCCATTAA |
AAATTATGTT |
GTCAAAGAAT |
ATTTGGTAAT |
ATGGAAAAGT |
AATTATAATG |
TGTTAGCAAG |
|
6161 |
AGAGAAAAAT |
AAGTTCCAAA |
CATAATGCAG |
AGAACTATCC |
CATTTGATAG |
AATACTGATA |
TACATGGATA |
CTATGTAACA |
|
6241 |
TTTACACATT |
TCTGAGAAAC |
ATAGAAAAGT |
CGGAACATAT |
AAAAGATATT |
ATTAATAGCT |
TCCGTGGGGT |
GACAGGATTA |
|
6321 |
TAAGTAGTTT |
TGATGGCTTT |
TTTTTTTAAT |
TTTTTCTTTT |
GTTATTGTTG |
TTTTTTTTAA |
ATTTAGAGAC |
CAGATCTCAC |
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6401 |
TCTGTTGCCC |
AGGCTGGAGT |
GCAGTGGTGC |
ATTATAGCTT |
ACTGTAACCT |
CAAACTCCTG |
GGCTCAAGCA |
ATCTTCCCAC |
|
6481 |
CTCAGCCTCC |
CAAATAGCTA |
GGACTACAGG |
CACACACCAT |
CACACCTGGA |
TAATAATAAT |
AATAGTAATT |
ATTATTATTA |
|
6561 |
TTTTGAGACA |
GAGTCTCACC |
CTTTTGCTGG |
GCTGGAGCGC |
AGTGGCGCGA |
TCTCGCCTCA |
CTGCAACCTC |
TGCCTCCCGG |
|
6641 |
GTTCAAGCAA |
TTCTCCTGCC |
TCAGCCTCCC |
AAGTAGCTGG |
GACTATAGGC |
ACGTGCCACC |
ATGTCCAGCT |
AATTTTTGTA |
|
6721 |
TTTTTAGTAG |
AGACGGAGTT |
TCACCGTGTT |
GGCCAGGAAG |
GTCTCGATCT |
CTTGACCTCG |
TGATCCACCT |
GCCTCGGCCT |
|
6801 |
CCCAAAGTGC |
TGGGATTACA |
GGCATAAGTC |
ACCACGCCCT |
GCCTATTATT |
ATTATTATTA |
TTATTTTTAG |
AAACAGTGCC |
|
6881 |
TCTCTATGTT |
GTCCAGGCTG |
GTCTCAAACT |
CCTGGCCTCG |
AGTCATCCTC |
CTGTCTCAGT |
CTCCCAAAGT |
GCAGACATTA |
|
6961 |
TAAGAGTGAG |
CCACTATGCC |
CGGCCTATTT |
TCTGCATTTT |
CTAACATACA |
CATGCACTAT |
CTTAAAGCAC |
AAAAAAAGCT |
|
7041 |
ATTAACAAAG |
AAATAATTAA |
AAGTAATTAG |
CTATAAGTTG |
TCAGTTTAAA |
AAAATCTGGA |
CTGCTATATT |
CAACAAAGTT |
|
7121 |
GTTTACATTC |
TAGATTTCAA |
GGCCCCTCAG |
AAGCACCTCC |
CTGTGTAAAT |
GAGGGTTCTT |
GCCTCCAGAA |
GGTGGCCCCA |
|
7201 |
CAAATGAGGA |
GTGAAAAGTA |
ACAGCCGAAT |
GGCCCCACTG |
TTGTACTAAT |
CTTGTTTGTT |
TAAAGAGAAA |
CTACAGACAC |
|
7281 |
TCTCTCTATT |
AAAGAAAAAA |
AGAATGAGGA |
GAGACCGAGA |
GAATTAGAAT |
GTGCTATATA |
CATTACAAGA |
TCAAAACCAG |
|
7361 |
TTTAGGCCCA |
AGTCTTCTTG |
TAATTTCATC |
TTTTTCCTCC |
CTGAGGGGGT |
TGGGAAGCCC |
TCTCTTACCA |
CAGGTTAAGA |
|
7441 |
GGCGAGAGGT |
CTGGTGGAAT |
TTCACATCCA |
CAGTGCCCTT |
AGGAAAAGCT |
GGGTGTTTTT |
GGCAGATTGA |
AGCATTCTTT |
|
7521 |
TTCCAGGCTG |
TGCTTTCACT |
ACTGGGTACA |
GATAATGTGG |
CTTAAAGAGC |
TAATCGGGAG |
CTGGAACAGA |
CAGAAATTCA |
|
7601 |
AGAGCAGAGA |
GGCATCAGGA |
CCTAGAACTT |
GGCCTAGACT |
CAGAGAGAGC |
TGATTCAAAG |
CTCAGAGCCA |
CCAGGGACCT |
|
7681 |
GCTGGGCGAC |
CCTGGATCCA |
TCACCAAGCC |
TCAGTTTCCA |
TGTTGGAAAC |
AAAGGGAGAA |
CGACGTCTGG |
GCTCAGAGTT |
|
7761 |
AGGAAAGCAC |
TCTGTTAGCT |
ATAAAGCAAG |
CTACATGGCA |
GAGTCGCCCT |
CAGCATGTGA |
CCCCGCTTCA |
AGCCTGCCAT |
|
7841 |
CCAGTCTGGG |
ATGTCAGACC |
CAGGGTTCTA |
CTGGCAGGTT |
AGAGAAGAGG |
AGTCAGGTGG |
GAGACTTGGA |
AGATTTGGTA |
|
7921 |
CAACACATGG |
AAGATTTGGT |
ACAACACAGA |
AGTTTCTGCG |
ATTTCCTCAG |
ACTAACCCTT |
AATTAACTAC |
AAACCACGGT |
|
8001 |
CTACGCCTCC |
TTTCCATCAA |
TTATCTTATT |
TCACCTTCAT |
AGCCAGCCTT |
GGAAGTGGAC |
TTAGGTGGGT |
CTGTATGGCA |
|
8081 |
GACAAGGTCC |
TTGAGGCTTA |
GATAACTAGA |
GTCTCTAGGG |
TAGGCCTAAG |
TCACACAGCA |
AGGCAGGTCC |
AGGGCCAGGA |
|
8161 |
TTTGAACCCA |
AGCCTCAGTC |
CTGAAGGATG |
CCCAAGGAAC |
ATAGATGCTG |
ACACGCCACA |
CTTTTCTTCC |
TTCCAGGCAA |
|
8241 |
ACATGAAGAG |
AAACAGCAAG |
AAGGTGGCAT |
TGTTTCTAAG |
AACTTCACAA |
AGAAAATCCA |
GTAAGTAACC |
TGGAGTCATG |
|
8321 |
GAGCTCAGGG |
TGGGAGTGGA |
GGAGGGGGCA |
CACCTGGGAC |
CCATGATCTG |
GGGTCTCTCC |
CTCTTGGGCA |
TCTCTCTTTT |
|
8401 |
AAGACACCTC |
CTTGGGGCAG |
GGAATTGAAC |
CCTCACACCT |
AACGAGGAGA |
AAATATCCCA |
GCAGACCTGT |
AATAGGGTCC |
|
8481 |
CAGAAGGGGG |
AGCACATAGA |
TTGCATCATC |
TCATCTGCTC |
GGTGCCCTGT |
GAGGTGGGTA |
TTAAAAACCC |
CATTTTATTT |
|
8561 |
ATTTATTATT |
TATTTATTTA |
TCTTGAGACC |
GAGTCTCACT |
CTGTCACCCA |
GTCTGGAGTG |
CAGCGGTGTG |
ATCCCAGCTC |
|
8641 |
ACTGCAACCT |
CCACCTCCTG |
GGTTCAAGCG |
GTCCGTGTGC |
CTCAGCCTCC |
TGAGTAGTTG |
GGATTACAGG |
CATGTGCCAC |
|
8721 |
CATGTCCGGC |
TAATTTTTTG |
TATTTGTTTA |
GTAGAGATGG |
GGTTTCGCCA |
TGTTGCCCAC |
ACTGGTCTTG |
AACTCCTGGG |
|
8801 |
CTCAAGCGAT |
CCACCCACCT |
CAGCCTCTCA |
AAGTGCTGGG |
ATTAGAGGCT |
TGAGCCACTG |
CACCCGGGGA |
ACAACTCCCT |
|
8881 |
TTTATAGACT |
AAGCATCTGA |
GGGTAAGCAA |
GACAATGACT |
TGTCCACAAT |
CACACAGCCC |
CTACCCATGG |
GGCATAGCTG |
|
8961 |
AGGGAGGACC |
CCTGTCACCA |
TCCAGAAAGA |
CCATCCCCTG |
ATTCCCCAAA |
TGCCCCAGCA |
GAATATCTTC |
CAGGCTGCTT |
|
9041 |
GCTCAGCCTC |
TGCCCTGCCA |
GGAAAATGAG |
CACCTTCTCT |
AGGGCATCCA |
CAAAAATGAA |
GTTGGAAAGT |
GTCCTGAGAA |
|
9121 |
CACTGCATAC |
TACCCAGAGA |
GGTTTGGAGG |
CTGAGACACT |
GGGACACAGG |
AAGAGCTATT |
TTGCTGAGGG |
GAGTAGAAGG |
|
9201 |
GATTCATGTT |
TAACAGGGAA |
AGGGAGCCTG |
GGGGAACCGT |
GAGAGCAGCC |
AAGGACAATC |
AGGCTGAGGC |
CATGAACCAA |
|
9281 |
AGCCACCACG |
AGCCCCTAGC |
TGGCAGTACC |
TATAGGGAGC |
AGAGTTGCAC |
AGTGTGGTCA |
CGATGGCTGC |
ACTTAAACAA |
|
9361 |
CTGCCAGGTG |
CTTCATACAT |
ACCTTCTCCC |
TAATCAGCAA |
TCAGCGTCAC |
TCCACTATGT |
GCGTTTCTGG |
CCCCTAAACT |
|
9441 |
CTCTCTCTCT |
CTCTCTCTCT |
TTTTTTTTTT |
TTTTTTGAGA |
TGGAGTCTCA |
CTCTGTTGCC |
CAGGCTGGAG |
TGCAGTGGCA |
|
9521 |
CGATGTCAGC |
TCACTGCAAC |
CTCTGCCTCC |
TGGGTTCAAG |
CAATTCTCCG |
GCCTCAATCT |
CCCAAGTAGC |
TGGGATTACA |
|
9601 |
GGTGCATGCC |
ACCATGCCTG |
GCTAATTTTT |
GTATTTTTAG |
TAGAGACGGG |
GTTTCACCAT |
GTTTGGCCAG |
CCTGGTCTTG |
|
9681 |
ATCTCCTGAC |
TTCAAGTGAT |
CTGCCCGCCT |
CTGCCTCCCA |
AAGTGCTGGG |
ATTACAGGTG |
TGAGCCACTG |
CGCCTGGCCC |
|
9761 |
CTAAACTCTT |
TTCCAAGCCA |
TCGTTGCATT |
TAGCCTTTGC |
AGCAAAAGTG |
TGCATCGGAG |
AGGAGACATG |
ACCCTCCTTG |
|
9841 |
CAATACAGGG |
AAACTAAGTC |
TCCCACAGGT |
GAAAGGACAT |
ACCCAAGGTC |
TTTACAGCTA |
GAATTTAGAA |
GGGCCCAGAA |
|
9921 |
TAGATCCCTG |
ACCTCTGAGT |
TCCATGCTCA |
GTCCTTGGGC |
AAGGAATGCT |
GTTTCCTCAT |
CTGTGAAAGG |
GATGCTGATT |
|
10001 |
CCAGCCTTGC |
AGAGTTCCTG |
GCTGAAAGTG |
ACATAAGGTC |
ATGGCCCAGC |
GTAGGTCCTC |
ATAAGTGGGA |
GTTCATTATT |
|
10081 |
ACTATTGTTA |
TTGTTGACTC |
TTAACTTTTC |
CATCAGCCTT |
TGCAAAGAAA |
TTCTGTGTGT |
GGAGAGATCA |
CACTAGCTGA |
|
10161 |
ATTCTGAGGC |
TTCTTCCAGC |
TTGGGATTCT |
ACATTCCTGT |
CTCTTCCCCC |
ACATGTCCGT |
CCCTGGCCCT |
CCCACAGCCT |
|
10241 |
CTGCAGTTCT |
TGGAAGCCTG |
TGGACACTTC |
CTGATAAGGC |
AAACGCCAAA |
CCATTTGTTC |
TTCGTGTTTG |
CTGGCTTGCC |
|
10321 |
TGGCATCTCC |
GTGCCCCACA |
CCTCTCCCTG |
GTTTAGCAAG |
CAGATTAAAC |
ATTGCTGAGG |
GAGAGGAAGG |
AAGGCAGGGG |
|
10401 |
GTGGGGGGAA |
GCTGATGTCA |
AGGCTCAAAT |
GAGGTCTCAG |
GGTGGAGTCA |
CAAGCAGGGC |
ATAGCTGTAA |
AAGGGACTGT |
|
10481 |
GTAAGAAAGA |
AGTGAATTAA |
TCATCTTAAA |
AGGGGTGTGT |
GTGTGTGTGT |
GTGTGTGTGT |
GTGTGTGTGT |
GTGTATTTCA |
|
10561 |
CATGCTCCAA |
GGCCTTAGGG |
GAGATAGCTT |
GCTGGAAGTA |
ACCTGATGAG |
AAATGCCTGA |
AATTGCTCCA |
GGCTGGTGCT |
|
10641 |
CAGCTGCTGA |
GCTGGGCTAG |
TTGTTAAAAT |
ATTCAGTGGT |
CCCCAACCTT |
TTTGGCACCA |
GGGACCAGTT |
TCGTAGAAGG |
|
10721 |
CAATTTTTCC |
ATGGACTGGG |
GAATGAAACT |
GTTCCACCTC |
AGATCATCGG |
GCATTAGATT |
CTCATAAGAA |
GCATGCAACC |
|
10801 |
TAGATCCCTC |
GCATGCACAG |
TTCACAACAG |
GGTTCAAGCT |
CCTATGAGAA |
TCTAATGCCA |
CTGCTGATCT |
GACAGGAGGC |
|
10881 |
GGAGCTCAGG |
CAGTAATGCT |
GGCTGAACTG |
CTGCTCACCT |
CCTGATGTGA |
AGCCTGGTTC |
CTAACAGGCC |
ACAGATGGGT |
|
10961 |
GCCGGTCCAT |
GATCCGGGGG |
ATGGGGACCC |
CTGAATATTG |
GCTAGCTATT |
GCCCTGAGCC |
CTCCCTAGCC |
AACCCCAGTC |
|
11041 |
ACTCTGATCT |
TGTCCCCAGG |
ACCCTCTAAA |
CCTCTCCACC |
TTCCAACAAC |
TAAAGGGTCC |
CAGGACCCTC |
CTCCATCACT |
|
11121 |
ATGACATGCA |
CCCATCCCTT |
CTGAATGGTC |
AGTGCCCAGC |
TGCACTAGTT |
GTTAAATATT |
TTGAATCTCA |
GCTCCGGGTG |
|
11201 |
CAGGGAGTCC |
TGGCTCCATG |
AGAAAGTGAG |
TGGGTAACTT |
GGGGCAACTT |
GCTTAACTGC |
TCTGACCTTC |
CATTCCCACA |
|
11281 |
TCCCTGCATG |
GAGGGGTTGT |
GATGGGAGTG |
AGAGGATGTG |
TATAACGCAT |
TAAGCATGGA |
ATACAGACTC |
AGGGCTTGGT |
|
11361 |
CCATGGGAAT |
TAATATTATG |
AAAAGGCTTC |
ACAAGGCTGG |
ACTCACACTC |
CAGCAGCTGG |
GACTCCTGGG |
AGCTCCTGGC |
|
11441 |
TCTGCCCAGA |
CTCTAGACAC |
CTAGGAGTCG |
AACTGGGGTC |
TGGGACACCT |
CTGGACCAAT |
CTCAGGAGTC |
CTCGTTGCCT |
|
11521 |
CCTCTCCCAG |
GGAAAACTCC |
AGTCATTAGA |
GGACAGGGAG |
ATTCCTTCAG |
CCAGGCTGAG |
ATCCTTGGAG |
ATTTCCACCC |
|
11601 |
AGGCAGGATG |
CTGCAGCTGT |
TTGCCTTAAC |
CATGGCAAGG |
AAATTCATCT |
CAACACATCC |
ATCTCTGTGT |
GAAAAGCCCC |
|
11681 |
ATTTGGACTG |
AATAAGGAGG |
AGAGGGAGAG |
GTCTTGGGTC |
TCAGCTTTCA |
AAGTCCATGA |
TCTTCCTATT |
TGGTTAGGGG |
|
11761 |
AAACCAAATT |
ACAGTCATTT |
GCAATACCGT |
CATTCACATC |
CCATCTTCAC |
TATTTTTTGC |
CTTATATGCT |
TACATTGCTG |
|
11841 |
TACCATGATT |
TACTAAAGGT |
TTTTTTTTCT |
TTTAGATCAT |
CTCATTTTTG |
ATAAAGTTAA |
ATTCTTATCA |
CTGAAATGTT |
|
11921 |
CACTGAGGAA |
AGCGATCATG |
AAATAAATCC |
AATGAAAGCA |
AACTGTGGTT |
AAATTCTAAC |
TAGATAATAT |
TGCCTGCCTA |
|
12001 |
AGGGCCTCAG |
CTCTCTCATT |
GTTAAAAAGG |
GAAGGTAGCA |
AGTGATAGAG |
GCTAAAGGCG |
TTAAAGGCAT |
GTTAGTACTT |
|
12081 |
AGCAGAGACA |
TTCCTTCAGA |
TGTAAGTAGA |
AGCACTGAAA |
GAGAACTGAA |
GAGGAATTAC |
TTTCCCACCA |
AATGGGTTTA |
|
12161 |
AATACAAGTC |
ACTTGGTTAG |
AGACCTTGGA |
CTTGTCTATC |
TCTCTGAGTT |
TCAGTTTCCC |
CATAAGTAAT |
ATAAGAGCAT |
|
12241 |
TGTCATGGAC |
AATCAGGAAG |
ATCCTTTGGG |
GCCCTGATAC |
TCTGTGGTTC |
AATGATCCTG |
CAATTTGTAT |
GATACTCCAT |
|
12321 |
CTTGCTGTCA |
AGATGCCAAC |
ATGTAAGGTC |
AAAGACTGCA |
ACGTAATTCT |
CACTCCACCC |
TAAGAGGTGG |
GTACTATTAT |
|
12401 |
TGCCCCCTTT |
TTTTCTGCAA |
AGAAACAGGT |
TCAAAGAGTC |
AAGATCACCA |
GCCCCATGTT |
GTGTGGTCAG |
GAAGAGTCAG |
|
12481 |
AATTTGAATG |
CACGTCAGCC |
TGCCTGCAAA |
ACCCATGCTC |
TAGGCCATAG |
CCACCCTGTC |
ACACTGTACC |
TGGTGTGCAC |
|
12561 |
TGGGTTGGTG |
TGCACATGGT |
TAAACAGTCA |
GCCCATCCCC |
AGCATTGGGA |
GGGAGGTCTA |
AACTTTTGAC |
TTTGTCTCCG |
|
12641 |
CTTCAAAAGC |
TTGACTTGGC |
AGCTTTCTAG |
TTCCCTCTTT |
TTCTTCCAAA |
TGGGCTTCCC |
AGAAGCAGCC |
TTGTTCATCT |
|
12721 |
CCATGGTTCC |
AATCTGGCAA |
GGAATCTCCT |
GGGTAGATAC |
GGCTCATGTG |
GCTACAGGTT |
GTTGTACCCA |
CAAAAAAAGA |
|
12801 |
AAGAAAGAAA |
GAAAAAAAAA |
AAACTCCCCA |
GCCCCTCCAG |
AAGGAGTCCT |
GCCTATGATC |
AGGAATGGGC |
TTACCTCATG |
|
12881 |
CCTTGGTTCT |
TTCATCAAGA |
CCCTCGTATT |
TACAATAGGC |
AGAGCCAGCA |
GGGATCAGTG |
GAAAGATTTT |
GATTGAACTG |
|
12961 |
CCGGTCCTTC |
CTGCCATAGT |
CCTTCTTTCA |
AATGTCTGGT |
GCTGGGGGAG |
GCAGGAGAGC |
ATCATGGTCA |
GATACTCTGA |
|
13041 |
GTTTGGAGAC |
CAGGATTCCA |
ATTCCATTTC |
CTATCTGCCA |
TTTGCCAGCT |
GAGCAACCTT |
GGGCAAAGCA |
GTTCACTTCT |
|
13121 |
CTGAGTCTCA |
ATTTCCTCAT |
CTGTAAGATG |
GGGATAGCAA |
TGGAATCTGC |
CTGGTGGGAT |
TATTGTTAAC |
ACCAAAATGA |
|
13201 |
TATGATTCAG |
CTAAAGTACC |
TGGCACATAG |
AAAGTACTCA |
GAAGGTCATG |
GATTTCATGG |
TTAAAAAAAA |
TAATGGCACC |
|
13281 |
CCAATGAGAT |
CACTAATATG |
TCCTCACAGT |
TTTAATAGTT |
TGTTGAAGAA |
ACCAAATTCT |
CAATAGTCTC |
ATTCACCCAA |
|
13361 |
AGCAATCCAA |
AAATCATAAA |
AATACCTTAT |
TAGAAGTTGG |
ACCAGATTTA |
GGTTTAGAAA |
TTCCATCTTC |
GATGCTTTCT |
|
13441 |
CACTTGTTGA |
GCTTGTCATT |
TGATTTCCCC |
CAAGTCTCTG |
TTTAGTGATC |
TGTAGAATGG |
GCATATTAAT |
TCTTACCTCT |
|
13521 |
TAATCATCCT |
CTTACAATAC |
TCCAACCAAG |
TATTGTCTAT |
AACTGAGTTT |
TAAGAACAAG |
ATAATTGGCT |
GGGCTCGGTG |
|
13601 |
GCTCACGCCT |
GTTATCTCAG |
CACTTTGGGA |
GGCTGAGGTG |
GGTGGATCAC |
AAGGTCAGGA |
GTTCGAGACC |
AGCCTGGCCA |
|
13681 |
ACATGGTGAA |
ACCCCATCTC |
TACTAAAAAT |
ACAAAAATTA |
GCCAGGCATG |
GTGGTGGGTG |
TCTGTAATCC |
ACACTACTCA |
|
13761 |
GGAGGCTGAG |
GCAGGAGAAT |
TGCTTGAACC |
TTGGGAGGCG |
GAACTTGCAG |
TGAACCAAGA |
TCGCGCCACT |
GAACTCCAGC |
|
13841 |
CTAGGTGACA |
GAGTGAGACT |
CTGTCCCAAA |
AAAATAAAAG |
GAAGAACAAG |
ATAATAATGA |
TCTGCTAAGT |
GATTGTATTA |
|
13921 |
GTCTGTTTTC |
ACACTGCTGA |
TAAAGACATA |
CCTGAGACTA |
CATAATTGAT |
ATATATATGA |
AAAAAAGAGT |
TTTAATGGAC |
|
14001 |
TCACAGTTCC |
ACATGGCTGG |
GGAGGCCTCA |
CAATCATGGC |
AAAAGGTGAA |
AGGCACGTCT |
TACATGGCAG |
CAGACAAGAG |
|
14081 |
AGAAAATGAG |
AACCAAGCAA |
AAAATCTTAT |
AAAACCGTCA |
GATCTCGTGA |
GACTTATTCC |
CTACCATGAG |
AACAGTATGG |
|
14161 |
AGGAAACTGC |
CCCCTACCCA |
TGATTCAATT |
ATCTCCCATC |
AGGCCTCTCC |
CACAACGTAT |
GGGAATTATG |
GGAGCTACAA |
|
14241 |
TTCAATATGA |
GATTTAGGTG |
GACACAGCCA |
AACCACATCA |
GAGATACTTA |
GGGTATGAAC |
AAAATCAAGG |
CTTATTTTGA |
|
14321 |
ATACCATCGA |
GTATGTTGCC |
ATCTGAAATC |
TACATGTGGC |
CAGCTTGGCC |
CCTTTTATCC |
ACCAAGGTAC |
CTAGTGCTTG |
|
14401 |
CATCACCATT |
AATGCATTTT |
GTAGTGAAGC |
ACTCTCCAGC |
AAGCACATGT |
CAGATGAAAA |
TGTGTTGCCT |
GTTATGATAA |
|
14481 |
CACCTTACTT |
GCGCTCTATA |
AAGGGATGGT |
AGTGGTGCCA |
TTTCTGCTAG |
TAATTGTGGT |
CAGTAGTGGG |
TATTAAGGTG |
|
14561 |
ATGACTTCAA |
CCTGGGACCA |
AATATGTGGG |
CCACAGCTCT |
CTTTTAAGTT |
AAGAACTACT |
GTTCAAACAG |
CATTTTACCA |
|
14641 |
TTTGCAAAGC |
ATACTCAGAC |
TCTGAAGTTC |
AAATACTCTA |
CAAGTTCAGT |
ATTATTATCC |
TCATTTTGCA |
GATGAGAAAA |
|
14721 |
CAAGCTCAGA |
GCAACTGAAT |
AATCTTCCCA |
AGACCACACA |
GCTAGAAAGG |
GGTAGAGCCA |
GGATTCAAAC |
CCAACATTGT |
|
14801 |
ATGTCCCCAA |
AGCCTAAGCT |
CTTATCAAAA |
ATATTTCCTC |
TCAAGTGAAT |
AAAAGAATGT |
TTAAGCAATA |
TTAACAACAA |
|
14881 |
TAAATGAATA |
AAATCGTGTG |
TTTCTCCTAG |
GCTTCCTGCA |
GAGGTGGATC |
CTGTGACAGT |
ATTTGCCTCA |
CTTTCCCCAG |
|
14961 |
AGGGTCTGCT |
GATCATCGAA |
GCTCCCCAGG |
TCCCTCCTTA |
CTCAACATTT |
GGAGAGAGCA |
GTTTCAACAA |
CGAGCTTCCC |
|
15041 |
CAGGACAGCC |
AGGAAGTCAC |
CTGTACCTGA |
GATGCCAGTA |
CTGGCCCATC |
CTTGTTTTGT |
CCCCAACCCT |
AGGGCTTCTC |
|
15121 |
TGATTCCAGG |
ATACATTACT |
TTAGCTGAAC |
TCAGATTTAG |
TGCAAGTAAA |
ATGTTAGAGG |
GTGCGGGGGT |
GAGGACTGAC |
|
15201 |
CACAGATTCC |
CTGGATAGTG |
TAGTGGTAGA |
TTTCTCCACA |
GGATAGCGCA |
ATTGGCAAAT |
CATGCTTGGT |
TGTGTTAGGC |
|
15281 |
CAAAATACTA |
GTTTTGCTTT |
CTTTACCTTT |
TCTATCTTGA |
TGAAAATGTT |
GCACATTCTA |
TAGTTGCAAA |
ACACATAAAA |
|
15361 |
GGGGACTTAA |
CATTTCACGT |
TGTATCTTAC |
TTGCAGTGAA |
TGCAAGGGTT |
ACTTTTCTCT |
GGGGACCTCC |
CCCATCACCC |
|
15441 |
AGGTTCCTAC |
TCTGGGCTCC |
CGATTCCCAT |
GGCTCCCAAA |
CCATGCCGCA |
TGGTTTGGTT |
AATGAAACCC |
AGTAGCTAAC |
|
15521 |
CCCACTGTGC |
TTCCACATGC |
CTGGCCTAAA |
ATGGGTGATA |
TACAGGTCTT |
ATATCCCCAT |
ATGGAATTTA |
TCCATCAACC |
|
15601 |
ACATAAAAAC |
AAACAGTGCC |
TTCTGCCCTC |
TGCCCAGATG |
TGTCCAGCAC |
GTTCTCAAAG |
TTTCCACATT |
AGCACTCCCT |
|
15681 |
AAGGACGCTG |
GGAGCCTGTC |
AGTTTATGAT |
CTGACCTAGG |
TCCCCCCTTT |
CTTCTGTCCC |
CTGTGTTTAA |
GTCGGGATTT |
|
15761 |
TTACAGAGGG |
AGCTGTCTCC |
AGACAGCTCC |
ATCAGGAACC |
AAGCAAAGGC |
CAGATAGCCT |
GACAGATAGG |
CTAGTGGTAT |
|
15841 |
TGTGTATATG |
GGCGGGACGT |
GTGTGTCATT |
ATTATTTGAG |
TTATGCTGTT |
GTTTAGGGGT |
AAATAACAGT |
AAATAATTAA |
|
15921 |
TAATAATAAT |
AATAATAATA |
AAGGAGCTGA |
CGTTCTT |
|
|
|
|
|
|
|
|
|
|
|
|
>ref|Gene_ID:26353|HSPB8|NC_000012.11:119616594...119632550 (+)
CCCACAGCCCAGCTGTTCCCTCCGCGGATTCTCCGGGGCTGGTTCATCACCTCCGAATATTCCTGTGACAGGAGACGCTT
GCAAAACCCGCCTCCAGCCTCCAGCAGCAAATAAATAGAAGGCTTGCAGCCCAGAAGGAGCCAGAAGAAGTTTCTAGGCG
CGCGTGCCCTGGGTTTATTAAGCTCCTGGCTCCGCTCTAGACCTCAGCGGTTCTGGCTGCCAGCCTGGGCAGCCTGGGAA
GCCTGGGAGGACGGTGGCTTGCCGGTCTGTCGTGAGGCAGTGCGGACGGGGACCCTCTGGGATTCTGCTGGATCTGCCCC
GGGGGTTACCTTTGGGGGCTGGGACCCCAGTCGAGGGGACACAACCGTCCCTGGCAGTGGTTGGTTCTGCTTCTCCCTGC
AGAAAAGCAGCATTTTCGGAAGCTGAAGAATAAGCTAGCCCAGCCACACCACCTTGTTGTGTGACCTTGGGCAGGTGGTT
CTGTCTCTCTGAGCCTCTGTTTCTCTCTGAGCTGAGCAGCCACCATGGCTGACGGTCAGATGCCCTTCTCCTGCCACTAC
CCAAGCCGCCTGCGCCGAGACCCCTTCCGGGACTCTCCCCTCTCCTCTCGCCTGCTGGATGATGGCTTTGGCATGGACCC
CTTCCCAGACGACTTGACAGCCTCTTGGCCCGACTGGGCTCTGCCTCGTCTCTCCTCCGCCTGGCCAGGCACCCTAAGGT
CGGGCATGGTGCCCCGGGGCCCCACTGCCACCGCCAGGTTTGGGGTGCCTGCCGAGGGCAGGACCCCCCCACCCTTCCCT
GGGGAGCCCTGGAAAGTGTGTGTGAATGTGCACAGCTTCAAGCCAGAGGAGTTGATGGTGAAGACCAAAGATGGATACGT
GGAGGTGTCTGGTAAGTCAGGGGCAGGAGGGAGAGAGAATGGGGAGGCCGGGATGTAGCCCTCAGCCCTGGGAATAGCCA
GAGAAAGTTTCCTGGGAGCTGACGTTGGGACAGTGTGACACAGGTGACCTCAGGGCTCAGGAATGCAGCCTGCAAAGTTA
TCTTTACGGAAAACTTCTCTCCCGGCTCCCAGCAGAGATCTTAACCTGCCTGACTCAGCTATTGGGGCCTCTGGGTGCTC
ATCAATCATGGTACAGACAGGAAAATAGAAACCATGTTGGATATTTTGACAGAGGGCATTTAATATAAAGAATAGGTTAA
GCAGATATCAAAGAATTAAAAAACAAAGAAGAAACGGGATTTTGTGCACTCCAGCATCATAACAGAGTCTAGAAGTGCAC
GTTAAGGCTGAACAATGATAGTGTTAATAACCGCAACTGGTTTCCGGTGAAACACCTCTCCTTGTCCCAGACAGGGAAAC
TGAGGCTTACCAGTAATTGTAGTAACACTAACTGGTAACTCTGAGTGCTAACTATTCGCTCAGCACTTTGCTAACTGCTG
TTGCCTATAATATCTCAGCTAATACCACAACCAGAGGAGGTGGGTACTGTTTATCTTCTTTTTTCAGATGAGGAAACTGA
GGCACGGAGAGATTAAAGTAACTTGTTCAAGGCCACCAAGGAGTCAGACCCAGGTTGTCTGGGAATTAGGAGGCCAGAAA
GAAGAAGTGATGATTTACTGAGCACCTACTAGGTGCCAAGGGTGGGCTGACATTCTTATACTTCTCCAAAATCATCCTCA
GTCCACTCCAGGGTAGCAGGGTAGGCCCATCTTGCAGCTGAGGAGGCTGAGGCCTAGGTGGGACTCGTTCACAGTCATGC
CATGAGTCAGCAATAGGAGTGGAGTAGGGACTGGGCCTATGCACAGCTTTAGGCCCAGGGCTCTCACTGCCGCATCCCAC
CCTGGGAGAAATAAACATACTAGGGGGAAAAATGAGAGAAGACAGGAAGCTCAGCCCCTGTGAAGCTGGGCAGTAGAAAA
ATCTTTCTTTTCCTTCCCTCCTGATTAACACTCCATTAAAAAGAATGTGTTCCCGGCAGAGGCTTGCCTTCCAGAAAATC
AGTCAAAGCCATTGCAAACACAGGCTGGGCAGGAACAAGCCCCAGCAGCATTCAGGGGGAGTTTCAAGCCAGTCCTGGTA
GAATTATAAACATCAGAGGCTCCAGCGGGTGTGGTGGGCTGGGAGACACGCTGGGGCCACGTGCTGATGACAGGGTCAGC
CAGATTTCTGAGTTGGCTGGGGAGCAGGGCATGAGTTCCGAAACTGGCTCCAACTTTAACCAGCAGGATGTGCAAATTAC
TTCACTTTGTGCTTCTGTTTTGTTTCCTCATCTGGAAATTAGGGTTCAAATGGTTATACCATAAGGATTGTTGTTTTAAG
TGAGGTGATGCTGTAAAATGTGTACATACCTGTGAACCCAGAAAATCTGAGACAGATCTCAGTTCATTTAGGAAGTTTAT
TTTGCCGAGGTTGAGGACACTCCCATGACACAGCCTCAGGAAGTCCTCCTGTCACATGCCCAAGGTGGTCTGGGCACAGC
TTAATTTTATACATTTTAGAGAGACATGAGACATCAATCAATATATGTAAGAAGTACATTGGTTCGATCTAGAAATGCAG
GACAACTTGAAGCAGGGAGGGGTTTTCCAGGTCACAGGTAGGTGAGAGACAAATGGTCGCATTCTTTTGAGTTTCTGATT
AGCCTTTCCAAAGGAGACAAACAGATAATGCATCTATGTCAGTGAGCAGAGGGCTGCCTTTGAATAGAATGGGGGGTAGG
TTGGCCCTAAACAGTTCCCAGCTTGACTTTTCCCTTTAGCTTAGTGATTTGGGGGCCCCAAGATTTATTTTCCTTTCACA
TTCTATGACCTGGAACACAAGGAATTAGTATTATTATTGTCGTCGTTATTGTTATAGTGTCAGGCATCCAGGAAGGCCCC
AATAAATAATGAATAATAGATGCTCTTTGAAACCTGGGTTCAGATCCCAGCACTGCTGTTCACTAGCATGGCGGATGTGG
ACGAGAAAGTCTTCATCCCTCTGAGCCTCATTTCTCCTATTTGCAGAATGGAGACCATAATAATATCTGTCCTGTAAGGG
TGTAGGAAAGATTAAACATATGCAGACTATCTATGATAATATATGCGGAGTGTCTATAAAATGGAGCTAATAATAGTGCT
TGCCTGGCACTCTGTAAACAGACCGATTATCACCATTCCTTCTGTCCTTGTTTTAATTAGGGTCTTAGATGCTTCTAGCC
CAAGTCCAAGGGTCGACTCCACCCTGTGGTCCCTCTAGGAGACCCTCTGTCCAGCCTGGAGGGTTTTTCACCATCCTCTT
TTGTAGGTGCTTCATAACAGGTGGGGTCTGGCAGCTCCATGTTGAGATCTCAGCTAAGTATCTTACTAATCCAGAGGCTT
TGGGTGAGTCATGCAGTCTCAATTTCCACGTCTGTAAAATGGGGTCATTGGGAGCTTAAATAAGACAAAGACAAAGCTTT
TCAGACATGCAATTAGTGACATCGGCTAGACAAAATCCAAATTCCCTGAGAGTCCATACAAGGGCTTTCATAAAAGGGGT
TTAAAAATAAAATTGATATCAGGAGCTCTATTTAAGAAGCAACTTTCGGGCCGGGTGCGGTGGCTCATGCCTGTAATCCC
AGCATTTTGGGAGGCCAAGGCGGGAGGATCGCTTAAGGTCAGGAGTCTGAGACCAGTCTGGTCAACATGGCGAAACCCCG
TTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGAGCGCCTGTAATCCCAGCTACTCAGGAGTCTGAGGCAGGAG
AATCGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGACCGTGCCACTGCATTCCAGCCTGGGCAACAAGAAAGAA
ATTCTGTCTCAAAAAAAATAAAAAATAAAAATAAATAAAAAGCAATTTTCAAGGGAAGTTGGAAGTCAGATCCAGTTTCC
CACCCTATACCACAAAATGACAAATCCGTTCCTCCACAAGCACGTGCTAAAGGCCTACATGTGGTGGCTCAGTGGTTCCT
CACAAGGACCTCCTAGGAAGTGTGGGTAGGTTTGTTAACCCCATTATACAGATAAGGAAGCCGAGGCCCAGAGAAAGTAA
CTCACCTGAGATTACCCACTTCTCCCTGGCAGTGTCTGACATTCAATGTCAGGCCTCTCTGGCTGGTTCTGAGTCAGGAT
GGCTGGATCTACTTCTGGCGGTGTGGCCCTGAGCAAATCCCACAGCCTCTGGAGCCTCAGTTTTACTGTTGGTCTTATGA
AGAGGTAGACAAGATCAGAATTTACCAATGTACTTCAAGCTGTTACTAGGCATCTAGAAACAGGAGCAGGAGAGTTCAAG
GTCTTGTATGGTGCCAGTAAAAACAAAATTATAAACAGGTCTTCTCACTGCAGGACTTATCAGAGCCTTTAAGTCACTAA
TGTAGTTTATGAATCTCTAAGAGGCAGCCCTATCTTATCTGACCACGTATGAGTGTCTCATTCAAGGAAGTGTTTGGAAA
ATGCTGGACTAGACAATTTCCAGCAAGCCTCAGATTCCCCTACCCCCATCCTGCAACCACCAGCCAAGAAATGTTCCCTT
CATGGGCCACTGGGCCAGACCCTGGCTAAGATAGAGACTGGAAAGCCCCAAGGCCTTATTTCCACCCCTTCTCCTTAGTC
CCAGGGACTCTGCCTTCCCTGGAAACAGCACTTTCTTTCTTTAGCTGGGCCAATAGTGTTCCACCTACATTTCTCTGAGG
CATGTTGAAAAAAGCATGTCTGCAAGGGGTTTCTGACTTCTCCTAGCCTCTGGATGTATTTCTAAAAATCATAATAATTA
CTTTTTTCAGTTTACAAAAATAAAATGTCTTCATGATAAAATATGTAGTTAGGAAAGCAAAATAAGAAATTAAAAATCAC
TCATAATCCTTAAGCTGCCCCAATCTAAGTAGGCAAATGATAAGCAAATTGAGTTTCAAGATGATCCTCCTAGCAACACT
CTCTTTAAATGAGGTTAACCCCACCTCCAGGCCCCTCTTTTGGAAATCTTGGAGCTTTCCCTGCTCAGAGATCCTCCCTT
CCCTCACCCCAATACCCTATTTTCAGAGCAGACAGAGGCACCTAGTTTCTGAGGAGCAGTCTTTTCCCCAAACATCAAAA
TAAACCACAAGTGTTTACCTTCACATGGTACTTTTACAACTTCCAAAGCCATTCTGTGACTCGCTTTCATTTGCTTCCTA
CGGTAACCCGGTAAGATAGGTGTCGTCATTCCCATTTCAGAGAAGAATAAACTGAGGCTCAGAGAAACTTAGAGATGTGC
CAGGAAATGTCAGAGTAGAGACTTAAGTCCAACACCCAATATTCCAGAACCTGTCTGCCTGCTTTTGAATCTTTGCACCA
GTCACTTCCAAGCTGTGTGACCTTGGATACAGCACTTAACCTCTCTGAACTTCGGGTTTCCTATCTACAAAATGACAATA
ATGAAAATGCCTGCTTATATTATTATTTTACTATTATTATTTAAGGTTGTTGCAAAAATTAAAGGAGTTGATACAGATAA
GGTGCTTAGAACAGTGGCTGACACCAAGGAAGCGCTATATTACTTGCTATTATTATTTATATTATCAGTTTTTATTCCCA
GGACACCAGCATGCAGGAGGATTCTAGGATGCAAAAGGGCTGAGTCAGAGGCACTGGCCTGTCCCCAGGGGAAGCAGGTC
TCCCGGCGCCCTGGCTGTGGGGAGGGTACCAAAGAACAGACAGTGCTCTTCTGGGCACAGGCCTGTGCTAGAGCCAGGCA
GTTGGTGGTCATGGAGTTGGCAGCACAAGGTAGACTCTTTAAGCGGCCACACATTCACAGGATAGCATGTTCTGGTTAGC
CAGACACTCCAGTTTAAAATGAATTTCTTTTGCTGAGAGCAATTTAGGAACATAGATTAAGCCTTAGAAATTCTGGAAGT
TGCATTAGTCCTCAGTTAATCCTAAAGAAGTCATAGGGCGGCCTGGTGTGAGGTTCTAGCTACAAGAATGTTCAGGGCCA
CGAAGTTCTCGCCAACGTTGGAAACTCTTCAGCACCCCAAAGTAGGGGATTGGTTAAATTAGCTCTTATGTATTCCTCAA
TAGAACACTGCAGCCATTAAAAATTATGTTGTCAAAGAATATTTGGTAATATGGAAAAGTAATTATAATGTGTTAGCAAG
AGAGAAAAATAAGTTCCAAACATAATGCAGAGAACTATCCCATTTGATAGAATACTGATATACATGGATACTATGTAACA
TTTACACATTTCTGAGAAACATAGAAAAGTCGGAACATATAAAAGATATTATTAATAGCTTCCGTGGGGTGACAGGATTA
TAAGTAGTTTTGATGGCTTTTTTTTTTAATTTTTTCTTTTGTTATTGTTGTTTTTTTTAAATTTAGAGACCAGATCTCAC
TCTGTTGCCCAGGCTGGAGTGCAGTGGTGCATTATAGCTTACTGTAACCTCAAACTCCTGGGCTCAAGCAATCTTCCCAC
CTCAGCCTCCCAAATAGCTAGGACTACAGGCACACACCATCACACCTGGATAATAATAATAATAGTAATTATTATTATTA
TTTTGAGACAGAGTCTCACCCTTTTGCTGGGCTGGAGCGCAGTGGCGCGATCTCGCCTCACTGCAACCTCTGCCTCCCGG
GTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTATAGGCACGTGCCACCATGTCCAGCTAATTTTTGTA
TTTTTAGTAGAGACGGAGTTTCACCGTGTTGGCCAGGAAGGTCTCGATCTCTTGACCTCGTGATCCACCTGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCATAAGTCACCACGCCCTGCCTATTATTATTATTATTATTATTTTTAGAAACAGTGCC
TCTCTATGTTGTCCAGGCTGGTCTCAAACTCCTGGCCTCGAGTCATCCTCCTGTCTCAGTCTCCCAAAGTGCAGACATTA
TAAGAGTGAGCCACTATGCCCGGCCTATTTTCTGCATTTTCTAACATACACATGCACTATCTTAAAGCACAAAAAAAGCT
ATTAACAAAGAAATAATTAAAAGTAATTAGCTATAAGTTGTCAGTTTAAAAAAATCTGGACTGCTATATTCAACAAAGTT
GTTTACATTCTAGATTTCAAGGCCCCTCAGAAGCACCTCCCTGTGTAAATGAGGGTTCTTGCCTCCAGAAGGTGGCCCCA
CAAATGAGGAGTGAAAAGTAACAGCCGAATGGCCCCACTGTTGTACTAATCTTGTTTGTTTAAAGAGAAACTACAGACAC
TCTCTCTATTAAAGAAAAAAAGAATGAGGAGAGACCGAGAGAATTAGAATGTGCTATATACATTACAAGATCAAAACCAG
TTTAGGCCCAAGTCTTCTTGTAATTTCATCTTTTTCCTCCCTGAGGGGGTTGGGAAGCCCTCTCTTACCACAGGTTAAGA
GGCGAGAGGTCTGGTGGAATTTCACATCCACAGTGCCCTTAGGAAAAGCTGGGTGTTTTTGGCAGATTGAAGCATTCTTT
TTCCAGGCTGTGCTTTCACTACTGGGTACAGATAATGTGGCTTAAAGAGCTAATCGGGAGCTGGAACAGACAGAAATTCA
AGAGCAGAGAGGCATCAGGACCTAGAACTTGGCCTAGACTCAGAGAGAGCTGATTCAAAGCTCAGAGCCACCAGGGACCT
GCTGGGCGACCCTGGATCCATCACCAAGCCTCAGTTTCCATGTTGGAAACAAAGGGAGAACGACGTCTGGGCTCAGAGTT
AGGAAAGCACTCTGTTAGCTATAAAGCAAGCTACATGGCAGAGTCGCCCTCAGCATGTGACCCCGCTTCAAGCCTGCCAT
CCAGTCTGGGATGTCAGACCCAGGGTTCTACTGGCAGGTTAGAGAAGAGGAGTCAGGTGGGAGACTTGGAAGATTTGGTA
CAACACATGGAAGATTTGGTACAACACAGAAGTTTCTGCGATTTCCTCAGACTAACCCTTAATTAACTACAAACCACGGT
CTACGCCTCCTTTCCATCAATTATCTTATTTCACCTTCATAGCCAGCCTTGGAAGTGGACTTAGGTGGGTCTGTATGGCA
GACAAGGTCCTTGAGGCTTAGATAACTAGAGTCTCTAGGGTAGGCCTAAGTCACACAGCAAGGCAGGTCCAGGGCCAGGA
TTTGAACCCAAGCCTCAGTCCTGAAGGATGCCCAAGGAACATAGATGCTGACACGCCACACTTTTCTTCCTTCCAGGCAA
ACATGAAGAGAAACAGCAAGAAGGTGGCATTGTTTCTAAGAACTTCACAAAGAAAATCCAGTAAGTAACCTGGAGTCATG
GAGCTCAGGGTGGGAGTGGAGGAGGGGGCACACCTGGGACCCATGATCTGGGGTCTCTCCCTCTTGGGCATCTCTCTTTT
AAGACACCTCCTTGGGGCAGGGAATTGAACCCTCACACCTAACGAGGAGAAAATATCCCAGCAGACCTGTAATAGGGTCC
CAGAAGGGGGAGCACATAGATTGCATCATCTCATCTGCTCGGTGCCCTGTGAGGTGGGTATTAAAAACCCCATTTTATTT
ATTTATTATTTATTTATTTATCTTGAGACCGAGTCTCACTCTGTCACCCAGTCTGGAGTGCAGCGGTGTGATCCCAGCTC
ACTGCAACCTCCACCTCCTGGGTTCAAGCGGTCCGTGTGCCTCAGCCTCCTGAGTAGTTGGGATTACAGGCATGTGCCAC
CATGTCCGGCTAATTTTTTGTATTTGTTTAGTAGAGATGGGGTTTCGCCATGTTGCCCACACTGGTCTTGAACTCCTGGG
CTCAAGCGATCCACCCACCTCAGCCTCTCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCCGGGGAACAACTCCCT
TTTATAGACTAAGCATCTGAGGGTAAGCAAGACAATGACTTGTCCACAATCACACAGCCCCTACCCATGGGGCATAGCTG
AGGGAGGACCCCTGTCACCATCCAGAAAGACCATCCCCTGATTCCCCAAATGCCCCAGCAGAATATCTTCCAGGCTGCTT
GCTCAGCCTCTGCCCTGCCAGGAAAATGAGCACCTTCTCTAGGGCATCCACAAAAATGAAGTTGGAAAGTGTCCTGAGAA
CACTGCATACTACCCAGAGAGGTTTGGAGGCTGAGACACTGGGACACAGGAAGAGCTATTTTGCTGAGGGGAGTAGAAGG
GATTCATGTTTAACAGGGAAAGGGAGCCTGGGGGAACCGTGAGAGCAGCCAAGGACAATCAGGCTGAGGCCATGAACCAA
AGCCACCACGAGCCCCTAGCTGGCAGTACCTATAGGGAGCAGAGTTGCACAGTGTGGTCACGATGGCTGCACTTAAACAA
CTGCCAGGTGCTTCATACATACCTTCTCCCTAATCAGCAATCAGCGTCACTCCACTATGTGCGTTTCTGGCCCCTAAACT
CTCTCTCTCTCTCTCTCTCTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCA
CGATGTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCGGCCTCAATCTCCCAAGTAGCTGGGATTACA
GGTGCATGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTTGGCCAGCCTGGTCTTG
ATCTCCTGACTTCAAGTGATCTGCCCGCCTCTGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCTGGCCC
CTAAACTCTTTTCCAAGCCATCGTTGCATTTAGCCTTTGCAGCAAAAGTGTGCATCGGAGAGGAGACATGACCCTCCTTG
CAATACAGGGAAACTAAGTCTCCCACAGGTGAAAGGACATACCCAAGGTCTTTACAGCTAGAATTTAGAAGGGCCCAGAA
TAGATCCCTGACCTCTGAGTTCCATGCTCAGTCCTTGGGCAAGGAATGCTGTTTCCTCATCTGTGAAAGGGATGCTGATT
CCAGCCTTGCAGAGTTCCTGGCTGAAAGTGACATAAGGTCATGGCCCAGCGTAGGTCCTCATAAGTGGGAGTTCATTATT
ACTATTGTTATTGTTGACTCTTAACTTTTCCATCAGCCTTTGCAAAGAAATTCTGTGTGTGGAGAGATCACACTAGCTGA
ATTCTGAGGCTTCTTCCAGCTTGGGATTCTACATTCCTGTCTCTTCCCCCACATGTCCGTCCCTGGCCCTCCCACAGCCT
CTGCAGTTCTTGGAAGCCTGTGGACACTTCCTGATAAGGCAAACGCCAAACCATTTGTTCTTCGTGTTTGCTGGCTTGCC
TGGCATCTCCGTGCCCCACACCTCTCCCTGGTTTAGCAAGCAGATTAAACATTGCTGAGGGAGAGGAAGGAAGGCAGGGG
GTGGGGGGAAGCTGATGTCAAGGCTCAAATGAGGTCTCAGGGTGGAGTCACAAGCAGGGCATAGCTGTAAAAGGGACTGT
GTAAGAAAGAAGTGAATTAATCATCTTAAAAGGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTCA
CATGCTCCAAGGCCTTAGGGGAGATAGCTTGCTGGAAGTAACCTGATGAGAAATGCCTGAAATTGCTCCAGGCTGGTGCT
CAGCTGCTGAGCTGGGCTAGTTGTTAAAATATTCAGTGGTCCCCAACCTTTTTGGCACCAGGGACCAGTTTCGTAGAAGG
CAATTTTTCCATGGACTGGGGAATGAAACTGTTCCACCTCAGATCATCGGGCATTAGATTCTCATAAGAAGCATGCAACC
TAGATCCCTCGCATGCACAGTTCACAACAGGGTTCAAGCTCCTATGAGAATCTAATGCCACTGCTGATCTGACAGGAGGC
GGAGCTCAGGCAGTAATGCTGGCTGAACTGCTGCTCACCTCCTGATGTGAAGCCTGGTTCCTAACAGGCCACAGATGGGT
GCCGGTCCATGATCCGGGGGATGGGGACCCCTGAATATTGGCTAGCTATTGCCCTGAGCCCTCCCTAGCCAACCCCAGTC
ACTCTGATCTTGTCCCCAGGACCCTCTAAACCTCTCCACCTTCCAACAACTAAAGGGTCCCAGGACCCTCCTCCATCACT
ATGACATGCACCCATCCCTTCTGAATGGTCAGTGCCCAGCTGCACTAGTTGTTAAATATTTTGAATCTCAGCTCCGGGTG
CAGGGAGTCCTGGCTCCATGAGAAAGTGAGTGGGTAACTTGGGGCAACTTGCTTAACTGCTCTGACCTTCCATTCCCACA
TCCCTGCATGGAGGGGTTGTGATGGGAGTGAGAGGATGTGTATAACGCATTAAGCATGGAATACAGACTCAGGGCTTGGT
CCATGGGAATTAATATTATGAAAAGGCTTCACAAGGCTGGACTCACACTCCAGCAGCTGGGACTCCTGGGAGCTCCTGGC
TCTGCCCAGACTCTAGACACCTAGGAGTCGAACTGGGGTCTGGGACACCTCTGGACCAATCTCAGGAGTCCTCGTTGCCT
CCTCTCCCAGGGAAAACTCCAGTCATTAGAGGACAGGGAGATTCCTTCAGCCAGGCTGAGATCCTTGGAGATTTCCACCC
AGGCAGGATGCTGCAGCTGTTTGCCTTAACCATGGCAAGGAAATTCATCTCAACACATCCATCTCTGTGTGAAAAGCCCC
ATTTGGACTGAATAAGGAGGAGAGGGAGAGGTCTTGGGTCTCAGCTTTCAAAGTCCATGATCTTCCTATTTGGTTAGGGG
AAACCAAATTACAGTCATTTGCAATACCGTCATTCACATCCCATCTTCACTATTTTTTGCCTTATATGCTTACATTGCTG
TACCATGATTTACTAAAGGTTTTTTTTTCTTTTAGATCATCTCATTTTTGATAAAGTTAAATTCTTATCACTGAAATGTT
CACTGAGGAAAGCGATCATGAAATAAATCCAATGAAAGCAAACTGTGGTTAAATTCTAACTAGATAATATTGCCTGCCTA
AGGGCCTCAGCTCTCTCATTGTTAAAAAGGGAAGGTAGCAAGTGATAGAGGCTAAAGGCGTTAAAGGCATGTTAGTACTT
AGCAGAGACATTCCTTCAGATGTAAGTAGAAGCACTGAAAGAGAACTGAAGAGGAATTACTTTCCCACCAAATGGGTTTA
AATACAAGTCACTTGGTTAGAGACCTTGGACTTGTCTATCTCTCTGAGTTTCAGTTTCCCCATAAGTAATATAAGAGCAT
TGTCATGGACAATCAGGAAGATCCTTTGGGGCCCTGATACTCTGTGGTTCAATGATCCTGCAATTTGTATGATACTCCAT
CTTGCTGTCAAGATGCCAACATGTAAGGTCAAAGACTGCAACGTAATTCTCACTCCACCCTAAGAGGTGGGTACTATTAT
TGCCCCCTTTTTTTCTGCAAAGAAACAGGTTCAAAGAGTCAAGATCACCAGCCCCATGTTGTGTGGTCAGGAAGAGTCAG
AATTTGAATGCACGTCAGCCTGCCTGCAAAACCCATGCTCTAGGCCATAGCCACCCTGTCACACTGTACCTGGTGTGCAC
TGGGTTGGTGTGCACATGGTTAAACAGTCAGCCCATCCCCAGCATTGGGAGGGAGGTCTAAACTTTTGACTTTGTCTCCG
CTTCAAAAGCTTGACTTGGCAGCTTTCTAGTTCCCTCTTTTTCTTCCAAATGGGCTTCCCAGAAGCAGCCTTGTTCATCT
CCATGGTTCCAATCTGGCAAGGAATCTCCTGGGTAGATACGGCTCATGTGGCTACAGGTTGTTGTACCCACAAAAAAAGA
AAGAAAGAAAGAAAAAAAAAAAACTCCCCAGCCCCTCCAGAAGGAGTCCTGCCTATGATCAGGAATGGGCTTACCTCATG
CCTTGGTTCTTTCATCAAGACCCTCGTATTTACAATAGGCAGAGCCAGCAGGGATCAGTGGAAAGATTTTGATTGAACTG
CCGGTCCTTCCTGCCATAGTCCTTCTTTCAAATGTCTGGTGCTGGGGGAGGCAGGAGAGCATCATGGTCAGATACTCTGA
GTTTGGAGACCAGGATTCCAATTCCATTTCCTATCTGCCATTTGCCAGCTGAGCAACCTTGGGCAAAGCAGTTCACTTCT
CTGAGTCTCAATTTCCTCATCTGTAAGATGGGGATAGCAATGGAATCTGCCTGGTGGGATTATTGTTAACACCAAAATGA
TATGATTCAGCTAAAGTACCTGGCACATAGAAAGTACTCAGAAGGTCATGGATTTCATGGTTAAAAAAAATAATGGCACC
CCAATGAGATCACTAATATGTCCTCACAGTTTTAATAGTTTGTTGAAGAAACCAAATTCTCAATAGTCTCATTCACCCAA
AGCAATCCAAAAATCATAAAAATACCTTATTAGAAGTTGGACCAGATTTAGGTTTAGAAATTCCATCTTCGATGCTTTCT
CACTTGTTGAGCTTGTCATTTGATTTCCCCCAAGTCTCTGTTTAGTGATCTGTAGAATGGGCATATTAATTCTTACCTCT
TAATCATCCTCTTACAATACTCCAACCAAGTATTGTCTATAACTGAGTTTTAAGAACAAGATAATTGGCTGGGCTCGGTG
GCTCACGCCTGTTATCTCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCA
ACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGTGGGTGTCTGTAATCCACACTACTCA
GGAGGCTGAGGCAGGAGAATTGCTTGAACCTTGGGAGGCGGAACTTGCAGTGAACCAAGATCGCGCCACTGAACTCCAGC
CTAGGTGACAGAGTGAGACTCTGTCCCAAAAAAATAAAAGGAAGAACAAGATAATAATGATCTGCTAAGTGATTGTATTA
GTCTGTTTTCACACTGCTGATAAAGACATACCTGAGACTACATAATTGATATATATATGAAAAAAAGAGTTTTAATGGAC
TCACAGTTCCACATGGCTGGGGAGGCCTCACAATCATGGCAAAAGGTGAAAGGCACGTCTTACATGGCAGCAGACAAGAG
AGAAAATGAGAACCAAGCAAAAAATCTTATAAAACCGTCAGATCTCGTGAGACTTATTCCCTACCATGAGAACAGTATGG
AGGAAACTGCCCCCTACCCATGATTCAATTATCTCCCATCAGGCCTCTCCCACAACGTATGGGAATTATGGGAGCTACAA
TTCAATATGAGATTTAGGTGGACACAGCCAAACCACATCAGAGATACTTAGGGTATGAACAAAATCAAGGCTTATTTTGA
ATACCATCGAGTATGTTGCCATCTGAAATCTACATGTGGCCAGCTTGGCCCCTTTTATCCACCAAGGTACCTAGTGCTTG
CATCACCATTAATGCATTTTGTAGTGAAGCACTCTCCAGCAAGCACATGTCAGATGAAAATGTGTTGCCTGTTATGATAA
CACCTTACTTGCGCTCTATAAAGGGATGGTAGTGGTGCCATTTCTGCTAGTAATTGTGGTCAGTAGTGGGTATTAAGGTG
ATGACTTCAACCTGGGACCAAATATGTGGGCCACAGCTCTCTTTTAAGTTAAGAACTACTGTTCAAACAGCATTTTACCA
TTTGCAAAGCATACTCAGACTCTGAAGTTCAAATACTCTACAAGTTCAGTATTATTATCCTCATTTTGCAGATGAGAAAA
CAAGCTCAGAGCAACTGAATAATCTTCCCAAGACCACACAGCTAGAAAGGGGTAGAGCCAGGATTCAAACCCAACATTGT
ATGTCCCCAAAGCCTAAGCTCTTATCAAAAATATTTCCTCTCAAGTGAATAAAAGAATGTTTAAGCAATATTAACAACAA
TAAATGAATAAAATCGTGTGTTTCTCCTAGGCTTCCTGCAGAGGTGGATCCTGTGACAGTATTTGCCTCACTTTCCCCAG
AGGGTCTGCTGATCATCGAAGCTCCCCAGGTCCCTCCTTACTCAACATTTGGAGAGAGCAGTTTCAACAACGAGCTTCCC
CAGGACAGCCAGGAAGTCACCTGTACCTGAGATGCCAGTACTGGCCCATCCTTGTTTTGTCCCCAACCCTAGGGCTTCTC
TGATTCCAGGATACATTACTTTAGCTGAACTCAGATTTAGTGCAAGTAAAATGTTAGAGGGTGCGGGGGTGAGGACTGAC
CACAGATTCCCTGGATAGTGTAGTGGTAGATTTCTCCACAGGATAGCGCAATTGGCAAATCATGCTTGGTTGTGTTAGGC
CAAAATACTAGTTTTGCTTTCTTTACCTTTTCTATCTTGATGAAAATGTTGCACATTCTATAGTTGCAAAACACATAAAA
GGGGACTTAACATTTCACGTTGTATCTTACTTGCAGTGAATGCAAGGGTTACTTTTCTCTGGGGACCTCCCCCATCACCC
AGGTTCCTACTCTGGGCTCCCGATTCCCATGGCTCCCAAACCATGCCGCATGGTTTGGTTAATGAAACCCAGTAGCTAAC
CCCACTGTGCTTCCACATGCCTGGCCTAAAATGGGTGATATACAGGTCTTATATCCCCATATGGAATTTATCCATCAACC
ACATAAAAACAAACAGTGCCTTCTGCCCTCTGCCCAGATGTGTCCAGCACGTTCTCAAAGTTTCCACATTAGCACTCCCT
AAGGACGCTGGGAGCCTGTCAGTTTATGATCTGACCTAGGTCCCCCCTTTCTTCTGTCCCCTGTGTTTAAGTCGGGATTT
TTACAGAGGGAGCTGTCTCCAGACAGCTCCATCAGGAACCAAGCAAAGGCCAGATAGCCTGACAGATAGGCTAGTGGTAT
TGTGTATATGGGCGGGACGTGTGTGTCATTATTATTTGAGTTATGCTGTTGTTTAGGGGTAAATAACAGTAAATAATTAA
TAATAATAATAATAATAATAAAGGAGCTGACGTTCTT
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Primary source |
RefSeq : NM_014365.2 (GI:38016940)
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Name |
Heat shock 22kDa protein 8 (HSPB8)
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
2056 nt
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Map |
12q24.23
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Location |
Chromosome 12 (NC_000012.11) strand : +
119616594...119617483 | 119624829...119624892 | 119631503...119632550 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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890
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890
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1
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Exon 2
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891
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954
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64
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1
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Exon 3
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955
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2002
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1048
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1
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Primary source |
NCBI : CCDS9189
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Nucleotide |
HSPB8, mRNA isoform 1[NM_014365.2] : 524...1114
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Length |
591
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Location |
Chromosome 12 (NC_000012.11) strand : +
119617117...119617483 | 119624829...119624892 | 119631503...119631662 |
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Start codon |
1
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Translation |
NP_055180.1 |
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1 |
CCACAGCCCA |
GCTGTTCCCT |
CCGCGGATTC |
TCCGGGGCTG |
GTTCATCACC |
TCCGAATATT |
CCTGTGACAG |
GAGACGCTTG |
|
81 |
CAAAACCCGC |
CTCCAGCCTC |
CAGCAGCAAA |
TAAATAGAAG |
GCTTGCAGCC |
CAGAAGGAGC |
CAGAAGAAGT |
TTCTAGGCGC |
|
161 |
GCGTGCCCTG |
GGTTTATTAA |
GCTCCTGGCT |
CCGCTCTAGA |
CCTCAGCGGT |
TCTGGCTGCC |
AGCCTGGGCA |
GCCTGGGAAG |
|
241 |
CCTGGGAGGA |
CGGTGGCTTG |
CCGGTCTGTC |
GTGAGGCAGT |
GCGGACGGGG |
ACCCTCTGGG |
ATTCTGCTGG |
ATCTGCCCCG |
|
321 |
GGGGTTACCT |
TTGGGGGCTG |
GGACCCCAGT |
CGAGGGGACA |
CAACCGTCCC |
TGGCAGTGGT |
TGGTTCTGCT |
TCTCCCTGCA |
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401 |
GAAAAGCAGC |
ATTTTCGGAA |
GCTGAAGAAT |
AAGCTAGCCC |
AGCCACACCA |
CCTTGTTGTG |
TGACCTTGGG |
CAGGTGGTTC |
|
481 |
TGTCTCTCTG |
AGCCTCTGTT |
TCTCTCTGAG |
CTGAGCAGCC |
ACCATGGCTG |
ACGGTCAGAT |
GCCCTTCTCC |
TGCCACTACC |
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561 |
CAAGCCGCCT |
GCGCCGAGAC |
CCCTTCCGGG |
ACTCTCCCCT |
CTCCTCTCGC |
CTGCTGGATG |
ATGGCTTTGG |
CATGGACCCC |
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641 |
TTCCCAGACG |
ACTTGACAGC |
CTCTTGGCCC |
GACTGGGCTC |
TGCCTCGTCT |
CTCCTCCGCC |
TGGCCAGGCA |
CCCTAAGGTC |
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721 |
GGGCATGGTG |
CCCCGGGGCC |
CCACTGCCAC |
CGCCAGGTTT |
GGGGTGCCTG |
CCGAGGGCAG |
GACCCCCCCA |
CCCTTCCCTG |
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801 |
GGGAGCCCTG |
GAAAGTGTGT |
GTGAATGTGC |
ACAGCTTCAA |
GCCAGAGGAG |
TTGATGGTGA |
AGACCAAAGA |
TGGATACGTG |
|
881 |
GAGGTGTCTG |
GCAAACATGA |
AGAGAAACAG |
CAAGAAGGTG |
GCATTGTTTC |
TAAGAACTTC |
ACAAAGAAAA |
TCCAGCTTCC |
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961 |
TGCAGAGGTG |
GATCCTGTGA |
CAGTATTTGC |
CTCACTTTCC |
CCAGAGGGTC |
TGCTGATCAT |
CGAAGCTCCC |
CAGGTCCCTC |
|
1041 |
CTTACTCAAC |
ATTTGGAGAG |
AGCAGTTTCA |
ACAACGAGCT |
TCCCCAGGAC |
AGCCAGGAAG |
TCACCTGTAC |
CTGAGATGCC |
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1121 |
AGTACTGGCC |
CATCCTTGTT |
TTGTCCCCAA |
CCCTAGGGCT |
TCTCTGATTC |
CAGGATACAT |
TACTTTAGCT |
GAACTCAGAT |
|
1201 |
TTAGTGCAAG |
TAAAATGTTA |
GAGGGTGCGG |
GGGTGAGGAC |
TGACCACAGA |
TTCCCTGGAT |
AGTGTAGTGG |
TAGATTTCTC |
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1281 |
CACAGGATAG |
CGCAATTGGC |
AAATCATGCT |
TGGTTGTGTT |
AGGCCAAAAT |
ACTAGTTTTG |
CTTTCTTTAC |
CTTTTCTATC |
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1361 |
TTGATGAAAA |
TGTTGCACAT |
TCTATAGTTG |
CAAAACACAT |
AAAAGGGGAC |
TTAACATTTC |
ACGTTGTATC |
TTACTTGCAG |
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1441 |
TGAATGCAAG |
GGTTACTTTT |
CTCTGGGGAC |
CTCCCCCATC |
ACCCAGGTTC |
CTACTCTGGG |
CTCCCGATTC |
CCATGGCTCC |
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1521 |
CAAACCATGC |
CGCATGGTTT |
GGTTAATGAA |
ACCCAGTAGC |
TAACCCCACT |
GTGCTTCCAC |
ATGCCTGGCC |
TAAAATGGGT |
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1601 |
GATATACAGG |
TCTTATATCC |
CCATATGGAA |
TTTATCCATC |
AACCACATAA |
AAACAAACAG |
TGCCTTCTGC |
CCTCTGCCCA |
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1681 |
GATGTGTCCA |
GCACGTTCTC |
AAAGTTTCCA |
CATTAGCACT |
CCCTAAGGAC |
GCTGGGAGCC |
TGTCAGTTTA |
TGATCTGACC |
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1761 |
TAGGTCCCCC |
CTTTCTTCTG |
TCCCCTGTGT |
TTAAGTCGGG |
ATTTTTACAG |
AGGGAGCTGT |
CTCCAGACAG |
CTCCATCAGG |
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1841 |
AACCAAGCAA |
AGGCCAGATA |
GCCTGACAGA |
TAGGCTAGTG |
GTATTGTGTA |
TATGGGCGGG |
ACGTGTGTGT |
CATTATTATT |
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1921 |
TGAGTTATGC |
TGTTGTTTAG |
GGGTAAATAA |
CAGTAAATAA |
TTAATAATAA |
TAATAATAAT |
AATAAAGGAG |
CTGACGTTCT |
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2001 |
TAAAAAAAAA |
AAAAAAAAAA |
AAAAAAAAAA |
AAAAAAAAAA |
AAAAAAAAAA |
AAAAAA |
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>gi|38016940|ref|NM_014365.2|Heat shock 22kDa protein 8 (HSPB8)
CCACAGCCCAGCTGTTCCCTCCGCGGATTCTCCGGGGCTGGTTCATCACCTCCGAATATTCCTGTGACAGGAGACGCTTG
CAAAACCCGCCTCCAGCCTCCAGCAGCAAATAAATAGAAGGCTTGCAGCCCAGAAGGAGCCAGAAGAAGTTTCTAGGCGC
GCGTGCCCTGGGTTTATTAAGCTCCTGGCTCCGCTCTAGACCTCAGCGGTTCTGGCTGCCAGCCTGGGCAGCCTGGGAAG
CCTGGGAGGACGGTGGCTTGCCGGTCTGTCGTGAGGCAGTGCGGACGGGGACCCTCTGGGATTCTGCTGGATCTGCCCCG
GGGGTTACCTTTGGGGGCTGGGACCCCAGTCGAGGGGACACAACCGTCCCTGGCAGTGGTTGGTTCTGCTTCTCCCTGCA
GAAAAGCAGCATTTTCGGAAGCTGAAGAATAAGCTAGCCCAGCCACACCACCTTGTTGTGTGACCTTGGGCAGGTGGTTC
TGTCTCTCTGAGCCTCTGTTTCTCTCTGAGCTGAGCAGCCACCATGGCTGACGGTCAGATGCCCTTCTCCTGCCACTACC
CAAGCCGCCTGCGCCGAGACCCCTTCCGGGACTCTCCCCTCTCCTCTCGCCTGCTGGATGATGGCTTTGGCATGGACCCC
TTCCCAGACGACTTGACAGCCTCTTGGCCCGACTGGGCTCTGCCTCGTCTCTCCTCCGCCTGGCCAGGCACCCTAAGGTC
GGGCATGGTGCCCCGGGGCCCCACTGCCACCGCCAGGTTTGGGGTGCCTGCCGAGGGCAGGACCCCCCCACCCTTCCCTG
GGGAGCCCTGGAAAGTGTGTGTGAATGTGCACAGCTTCAAGCCAGAGGAGTTGATGGTGAAGACCAAAGATGGATACGTG
GAGGTGTCTGGCAAACATGAAGAGAAACAGCAAGAAGGTGGCATTGTTTCTAAGAACTTCACAAAGAAAATCCAGCTTCC
TGCAGAGGTGGATCCTGTGACAGTATTTGCCTCACTTTCCCCAGAGGGTCTGCTGATCATCGAAGCTCCCCAGGTCCCTC
CTTACTCAACATTTGGAGAGAGCAGTTTCAACAACGAGCTTCCCCAGGACAGCCAGGAAGTCACCTGTACCTGAGATGCC
AGTACTGGCCCATCCTTGTTTTGTCCCCAACCCTAGGGCTTCTCTGATTCCAGGATACATTACTTTAGCTGAACTCAGAT
TTAGTGCAAGTAAAATGTTAGAGGGTGCGGGGGTGAGGACTGACCACAGATTCCCTGGATAGTGTAGTGGTAGATTTCTC
CACAGGATAGCGCAATTGGCAAATCATGCTTGGTTGTGTTAGGCCAAAATACTAGTTTTGCTTTCTTTACCTTTTCTATC
TTGATGAAAATGTTGCACATTCTATAGTTGCAAAACACATAAAAGGGGACTTAACATTTCACGTTGTATCTTACTTGCAG
TGAATGCAAGGGTTACTTTTCTCTGGGGACCTCCCCCATCACCCAGGTTCCTACTCTGGGCTCCCGATTCCCATGGCTCC
CAAACCATGCCGCATGGTTTGGTTAATGAAACCCAGTAGCTAACCCCACTGTGCTTCCACATGCCTGGCCTAAAATGGGT
GATATACAGGTCTTATATCCCCATATGGAATTTATCCATCAACCACATAAAAACAAACAGTGCCTTCTGCCCTCTGCCCA
GATGTGTCCAGCACGTTCTCAAAGTTTCCACATTAGCACTCCCTAAGGACGCTGGGAGCCTGTCAGTTTATGATCTGACC
TAGGTCCCCCCTTTCTTCTGTCCCCTGTGTTTAAGTCGGGATTTTTACAGAGGGAGCTGTCTCCAGACAGCTCCATCAGG
AACCAAGCAAAGGCCAGATAGCCTGACAGATAGGCTAGTGGTATTGTGTATATGGGCGGGACGTGTGTGTCATTATTATT
TGAGTTATGCTGTTGTTTAGGGGTAAATAACAGTAAATAATTAATAATAATAATAATAATAATAAAGGAGCTGACGTTCT
TAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
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Exon number |
1
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Length |
890 nt
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Location |
Chromosome 12 (NC_000012.11) : 119616594...119617483 (+)
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Is part of |
HSPB8, mRNA isoform 1
(NM_014365.2)
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Sequence |
Show
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CCACAGCCCAGCTGTTCCCTCCGCGGATTCTCCGGGGCTGGTTCATCACCTCCGAATATTCCTGTGACAGGAGACGCTTG
CAAAACCCGCCTCCAGCCTCCAGCAGCAAATAAATAGAAGGCTTGCAGCCCAGAAGGAGCCAGAAGAAGTTTCTAGGCGC
GCGTGCCCTGGGTTTATTAAGCTCCTGGCTCCGCTCTAGACCTCAGCGGTTCTGGCTGCCAGCCTGGGCAGCCTGGGAAG
CCTGGGAGGACGGTGGCTTGCCGGTCTGTCGTGAGGCAGTGCGGACGGGGACCCTCTGGGATTCTGCTGGATCTGCCCCG
GGGGTTACCTTTGGGGGCTGGGACCCCAGTCGAGGGGACACAACCGTCCCTGGCAGTGGTTGGTTCTGCTTCTCCCTGCA
GAAAAGCAGCATTTTCGGAAGCTGAAGAATAAGCTAGCCCAGCCACACCACCTTGTTGTGTGACCTTGGGCAGGTGGTTC
TGTCTCTCTGAGCCTCTGTTTCTCTCTGAGCTGAGCAGCCACCATGGCTGACGGTCAGATGCCCTTCTCCTGCCACTACC
CAAGCCGCCTGCGCCGAGACCCCTTCCGGGACTCTCCCCTCTCCTCTCGCCTGCTGGATGATGGCTTTGGCATGGACCCC
TTCCCAGACGACTTGACAGCCTCTTGGCCCGACTGGGCTCTGCCTCGTCTCTCCTCCGCCTGGCCAGGCACCCTAAGGTC
GGGCATGGTGCCCCGGGGCCCCACTGCCACCGCCAGGTTTGGGGTGCCTGCCGAGGGCAGGACCCCCCCACCCTTCCCTG
GGGAGCCCTGGAAAGTGTGTGTGAATGTGCACAGCTTCAAGCCAGAGGAGTTGATGGTGAAGACCAAAGATGGATACGTG
GAGGTGTCTG
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Exon number |
3
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Length |
1048 nt
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Location |
Chromosome 12 (NC_000012.11) : 119631503...119632550 (+)
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Is part of |
HSPB8, mRNA isoform 1
(NM_014365.2)
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Sequence |
Show
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GCTTCCTGCAGAGGTGGATCCTGTGACAGTATTTGCCTCACTTTCCCCAGAGGGTCTGCTGATCATCGAAGCTCCCCAGG
TCCCTCCTTACTCAACATTTGGAGAGAGCAGTTTCAACAACGAGCTTCCCCAGGACAGCCAGGAAGTCACCTGTACCTGA
GATGCCAGTACTGGCCCATCCTTGTTTTGTCCCCAACCCTAGGGCTTCTCTGATTCCAGGATACATTACTTTAGCTGAAC
TCAGATTTAGTGCAAGTAAAATGTTAGAGGGTGCGGGGGTGAGGACTGACCACAGATTCCCTGGATAGTGTAGTGGTAGA
TTTCTCCACAGGATAGCGCAATTGGCAAATCATGCTTGGTTGTGTTAGGCCAAAATACTAGTTTTGCTTTCTTTACCTTT
TCTATCTTGATGAAAATGTTGCACATTCTATAGTTGCAAAACACATAAAAGGGGACTTAACATTTCACGTTGTATCTTAC
TTGCAGTGAATGCAAGGGTTACTTTTCTCTGGGGACCTCCCCCATCACCCAGGTTCCTACTCTGGGCTCCCGATTCCCAT
GGCTCCCAAACCATGCCGCATGGTTTGGTTAATGAAACCCAGTAGCTAACCCCACTGTGCTTCCACATGCCTGGCCTAAA
ATGGGTGATATACAGGTCTTATATCCCCATATGGAATTTATCCATCAACCACATAAAAACAAACAGTGCCTTCTGCCCTC
TGCCCAGATGTGTCCAGCACGTTCTCAAAGTTTCCACATTAGCACTCCCTAAGGACGCTGGGAGCCTGTCAGTTTATGAT
CTGACCTAGGTCCCCCCTTTCTTCTGTCCCCTGTGTTTAAGTCGGGATTTTTACAGAGGGAGCTGTCTCCAGACAGCTCC
ATCAGGAACCAAGCAAAGGCCAGATAGCCTGACAGATAGGCTAGTGGTATTGTGTATATGGGCGGGACGTGTGTGTCATT
ATTATTTGAGTTATGCTGTTGTTTAGGGGTAAATAACAGTAAATAATTAATAATAATAATAATAATAATAAAGGAGCTGA
CGTTCTTA
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Primary source |
Uniprot : Q9UJY1
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Name |
Heat shock protein beta-8
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Alternative name(s) |
Alpha-crystallin C chain E2-induced gene 1 protein Protein kinase H11 Small stress protein-like protein HSP22
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Synonym(s) |
HspB8
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Organism |
Homo sapiens
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Length |
196 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Disease
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Defects in HSPB8 are the cause of distal hereditary motor neuronopathy type 2A (HMN2A) [MIM:158590]; also known as distal hereditary motor neuropathy type IIA or spinal Charcot-Marie-Tooth disease IIA. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective impairment of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
Defects in HSPB8 are the cause of Charcot-Marie-Tooth disease type 2L (CMT2L) [MIM:608673]. CMT2L is an axonal form of Charcot-Marie-Tooth disease. Axonal CMT neuropathies are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
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Function
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Displays temperature-dependent chaperone activity.
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Induction
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By 17-beta-estradiol.
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Similarity
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Belongs to the small heat shock protein (HSP20) family.
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Subunit
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Monomer. Interacts with HSPB1.
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Tissue specificity
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Predominantly expressed in skeletal muscle and heart.
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Biological process
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cell death [GO:0008219]
response to heat [GO:0009408]
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Cellular component
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intracellular [GO:0005622]
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Molecular function
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protein serine/threonine kinase activity [GO:0004674]
identical protein binding [GO:0042802]
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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Natural variations |
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Natural variant site
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67 - 67
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1
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G -> S (in a glioblastoma multiforme sample; somatic mutation)
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VAR_042244
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Natural variant site
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78 - 78
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1
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R -> M (in dbSNP:rs55826713)
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VAR_042245
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Natural variant site
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141 - 141
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1
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K -> E (in HMN2A; strengthen interaction with HSPB1)
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VAR_018504
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Natural variant site
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141 - 141
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1
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K -> N (in HMN2A and CMT2L; strengthen interaction with HSPB1)
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VAR_018505
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Amino acid modifications |
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Modified residue
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24 - 24
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1
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Phosphoserine
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Q9UJY1-MOD_RES-24
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Modified residue
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63 - 63
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1
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Phosphothreonine; by PKC; in vitro
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Q9UJY1-MOD_RES-63
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Modified residue
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118 - 118
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1
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Phosphotyrosine
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Q9UJY1-MOD_RES-118
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1 |
MADGQMPFSC |
HYPSRLRRDP |
FRDSPLSSRL |
LDDGFGMDPF |
PDDLTASWPD |
WALPRLSSAW |
PGTLRSGMVP |
RGPTATARFG |
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81 |
VPAEGRTPPP |
FPGEPWKVCV |
NVHSFKPEEL |
MVKTKDGYVE |
VSGKHEEKQQ |
EGGIVSKNFT |
KKIQLPAEVD |
PVTVFASLSP |
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161 |
EGLLIIEAPQ |
VPPYSTFGES |
SFNNELPQDS |
QEVTCT |
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>sp|Q9UJY1|HSPB8_human Heat shock protein beta-8
MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFG
VPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSP
EGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT
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