(HSPA5) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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5237
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Official symbol
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HSPA5
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Official name
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heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 9 (NC_000009.11) : 127997126...128003660 (-)
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Map
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9q33.3
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Length
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6535 nt
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NM_005347.3
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HSPA5, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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P11021
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78 kDa glucose-regulated protein
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Homo sapiens
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654 aa
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Synonyms |
MIF2; FLJ26106; GRP78; BiP
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Alternative name(s) |
Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD); heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
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Summary |
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM].
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Related Articles in PubMed
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Go to ensembl
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1 |
GGGGAGGGTA |
TATAAGCCGA |
GTAGGCGACG |
GTGAGGTCGA |
CGCCGGCCAA |
GACAGCACAG |
ACAGATTGAC |
CTATTGGGGT |
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81 |
GTTTCGCGAG |
TGTGAGAGGG |
AAGCGCCGCG |
GCCTGTATTT |
CTAGACCTGC |
CCTTCGCCTG |
GTTCGTGGCG |
CCTTGTGACC |
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161 |
CCGGGCCCCT |
GCCGCCTGCA |
AGTCGGAAAT |
TGCGCTGTGC |
TCCTGTGCTA |
CGGCCTGTGG |
CTGGACTGCC |
TGCTGCTGCC |
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241 |
CAACTGGCTG |
GCAAGATGAA |
GCTCTCCCTG |
GTGGCCGCGA |
TGCTGCTGCT |
GCTCAGCGCG |
GCGCGGGCCG |
AGGAGGAGGA |
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321 |
CAAGAAGGAG |
GACGTGGGCA |
CGGTGGTCGG |
CATCGACCTG |
GGGACCACCT |
ACTCCTGGTA |
AGTGGGGTTG |
CGGATGCAGG |
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401 |
GGGACGGGGC |
GTGGCCGCCT |
GGCCTGGCGT |
GAGAAGTGCG |
GTGCTGATGT |
CCCTCTGTCG |
GGTTTTTCTG |
CCAGCGTCGG |
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481 |
CGTGTTCAAG |
AACGGCCGCG |
TGGAGATCAT |
CGCCAACGAT |
CAGGGCAACC |
GCATCACGCC |
GTCCTATGTC |
GCCTTCACTC |
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561 |
CTGAAGGGGA |
ACGTCTGATT |
GGCGATGCCG |
CCAAGAACCA |
GCTCACCTCC |
AACCCCGAGA |
ACACGGTCTT |
TGACGCCAAG |
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641 |
CGGCTCATCG |
GCCGCACGTG |
GAATGACCCG |
TCTGTGCAGC |
AGGACATCAA |
GTTCTTGCCG |
TTCAAGGTTC |
GACCGGGTTT |
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721 |
TTCTCATCCA |
GTTAGAGAAC |
GGGTGGGTGG |
TGGGAGTATT |
TAGAGTTATA |
AGTCTCTGGA |
AAAGTGTTGA |
GACAACAGTT |
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801 |
GAAGGTTATA |
GACATGATGT |
ATGTAATAAC |
TTTAATACTA |
TTAGTATGTT |
ACAAAACTTA |
AGACAGTTGC |
TGTCGTACTG |
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881 |
TCTACGATAG |
TTTAGGAATA |
AAAGACCGAT |
TAAAACTGAA |
CTTTGTAAGA |
CACCTATACT |
CCCTGAAGTA |
TTTCTAGTCA |
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961 |
ATTTGCAGCC |
CCAAGGGACC |
AAAATAAACC |
AAATTGTGGG |
GATGGTAGTG |
GGTCTTTTAA |
ACTTTGAGAT |
GTCATTGTAT |
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1041 |
CTGTGTCTGA |
AAACAATAAT |
TCTTTAAAAT |
AGGTGGTTGA |
AAAGAAAACT |
AAACCATACA |
TTCAAGTTGA |
TATTGGAGGT |
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1121 |
GGGCAAACAA |
AGACATTTGC |
TCCTGAAGAA |
ATTTCTGCCA |
TGGTTCTCAC |
TAAAATGAAA |
GAAACCGCTG |
AGGCTTATTT |
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1201 |
GGGAAAGAAG |
GTAAATATTT |
CTAGAACAAT |
GTTAAGTATT |
TTTTGATCAT |
TAGTATTCTC |
GGTTGGCTGT |
TATGTATAGA |
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1281 |
AGCCTTCGTG |
AAGGGTTTCA |
AAAATTTTAA |
TCAGAATGGT |
ATTCATGCTT |
GTCAGGTTTA |
ATTATTGAGT |
CCCTTACTAT |
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1361 |
AAGCCAAACA |
AAATAGACTT |
TTCATGTATT |
ATTTAATGCT |
TACAATTCCA |
GGGACATAAA |
ATTTTATATG |
TTGTATTCAT |
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1441 |
CAATAAGTTG |
GCTTAAAAAC |
TAAAGTGATG |
GTTTGACTGT |
AATTTTTTTT |
TTTTGAGATG |
GAGTCTTGCT |
CTGTTGCCCA |
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1521 |
GGCTGGACTG |
CAGTGGCACG |
ATCTCAGCTC |
ACTGCAACCT |
CTGCCTCCCG |
GGTTCAAGCA |
GCTCTCCTGC |
CTCAGCCTCC |
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1601 |
CAAGTAACTG |
GAACTACAGG |
CACACCACCA |
CACCTGGCTA |
ATTTTTTTTT |
TTTTTTTTAA |
TTTTCAGTAG |
AGACAGGGTT |
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1681 |
TCTCCACATT |
GCCCAGGCTG |
GTCTTGAAAT |
CCTGCCCTCA |
GGTGATCCTC |
CTGCCTCAGC |
CTCCCAAAGT |
GCTGGGATTA |
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1761 |
TAGGCAGAAG |
CCACCGCCTG |
GCCAGACTGT |
AATTTAAATA |
AGGGTTAAAC |
TATGTGACAA |
TACACTTAAT |
TATCTTTTAT |
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1841 |
CCTTTTAGGT |
TACCCATGCA |
GTTGTTACTG |
TACCAGCCTA |
TTTTAATGAT |
GCCCAACGCC |
AAGCAACCAA |
AGACGCTGGA |
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1921 |
ACTATTGCTG |
GCCTAAATGT |
TATGAGGATC |
ATCAACGAGC |
CGTAAGTATG |
AAATTCAGGG |
ATACGGCATA |
TTTGCCAAAT |
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2001 |
AGTGGAAATG |
TGAAGTACTG |
ACAAAACTTT |
TCCCTTTTTC |
AATCTAATAG |
TACGGCAGCT |
GCTATTGCTT |
ATGGCCTGGA |
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2081 |
TAAGAGGGAG |
GGGGAGAAGA |
ACATCCTGGT |
GTTTGACCTG |
GGTGGCGGAA |
CCTTCGATGT |
GTCTCTTCTC |
ACCATTGACA |
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2161 |
ATGGTGTCTT |
CGAAGTTGTG |
GCCACTAATG |
GAGATACTCA |
TCTGGGTGGA |
GAAGACTTTG |
ACCAGCGTGT |
CATGGAACAC |
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2241 |
TTCATCAAAC |
TGTACAAAAA |
GAAGACGGGC |
AAAGATGTCA |
GGAAAGACAA |
TAGAGCTGTG |
CAGAAACTCC |
GGCGCGAGGT |
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2321 |
AGAAAAGGCC |
AAACGGGCCC |
TGTCTTCTCA |
GCATCAAGCA |
AGAATTGAAA |
TTGAGTCCTT |
CTATGAAGGA |
GAAGACTTTT |
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2401 |
CTGAGACCCT |
GACTCGGGCC |
AAATTTGAAG |
AGCTCAACAT |
GGTATGTTCC |
TTGTTTTCTG |
CTTTGCTAAT |
GAGATCTCCT |
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2481 |
TAGACTCTGA |
ATTCAGGACA |
TTGCATCTAG |
ATACTTAGAT |
AACAGACATC |
ACAGTAACCA |
TGTCTTTTTT |
CTAGGATCTG |
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2561 |
TTCCGGTCTA |
CTATGAAGCC |
CGTCCAGAAA |
GTGTTGGAAG |
ATTCTGATTT |
GAAGAAGTCT |
GATATTGATG |
AAATTGTTCT |
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2641 |
TGTTGGTGGC |
TCGACTCGAA |
TTCCAAAGAT |
TCAGCAACTG |
GTTAAAGAGT |
TCTTCAATGG |
CAAGGAACCA |
TCCCGTGGCA |
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2721 |
TAAACCCAGA |
TGAAGCTGTA |
GCGTATGGTG |
CTGCTGTCCA |
GGCTGGTGTG |
CTCTCTGGTG |
ATCAAGATAC |
AGGTAGGTCA |
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2801 |
TCATCGCAGC |
ATCTTTCTTA |
GTGATTCAGT |
AGCTTGATGG |
AAGACTCATT |
AGCTATTGCT |
TTAGAAAATA |
CCAGAATATG |
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2881 |
AGCAACAAGG |
TCACACAGCT |
AGTAAAGGGT |
ATAAGTGAAG |
ACAAGACTGG |
GGTAGTCTCA |
AGATCATTAG |
CAACTGTTTA |
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2961 |
ATTCACTGCC |
TTTAAAATGT |
GTGTGTTAGA |
ACCTAACCAA |
ATGTTAGAGA |
GATAAACTTT |
ACATAGCTCA |
TAGGGAGAAC |
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3041 |
TTGAATTAAA |
AGTTAAATAA |
CTTATCCTTA |
CAGGTGACCT |
GGTACTGCTT |
GATGTATGTC |
CCCTTACACT |
TGGTATTGAA |
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3121 |
ACTGTGGGAG |
GTGTCATGAC |
CAAACTGATT |
CCAAGGAACA |
CAGTGGTGCC |
TACCAAGAAG |
TCTCAGATCT |
TTTCTACAGC |
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3201 |
TTCTGATAAT |
CAACCAACTG |
TTACAATCAA |
GGTCTATGAA |
GGTAATTACT |
TAAGTTTGTT |
AATATCATGG |
CTTTTTTTTT |
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3281 |
GAGATGAAGT |
CTTGCTCTGT |
TGCCCAGGCT |
GGACTGCAGT |
GGCACGATCT |
CGGCTCACTG |
CAAATTCTGT |
CTCCCGGGTT |
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3361 |
CAAGTGATTC |
TCCTGCCTCA |
GCCTCCAGAG |
TAGCTGGGAT |
TACAGGCGTG |
GACCACCACA |
CCTGGCTAAT |
TTCTGTATTT |
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3441 |
TTAGTAGAGA |
TGGGGTTTCA |
CCATGTTTCC |
CAGGCTGGTC |
TCCAACTCCT |
GACCTCAGGT |
CATCTGCCTG |
CCTCCACCTC |
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3521 |
CCAAAGTGCT |
GGGATTATAG |
GCGTGAGCCA |
CCACGCCAGA |
TCTATCTATC |
ATGGCATATT |
TTAAAAGAAC |
ATGACTTAAT |
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3601 |
ATGTCCTATT |
GAAATGGCTA |
GGGAACTAAG |
TAACTGCTGT |
TTTCAGATGG |
AGGTCTTAAT |
TTGAATAATG |
TTGATATTAG |
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3681 |
ATATTTAGCA |
TTCTTTTTTT |
TTTTTTTTTA |
ATGGAGTCTT |
GCTCTGTCGC |
CTAGGCTGGG |
GTGCAGTGGC |
ATGACTTGCA |
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3761 |
ACCTCTGCCT |
CCCGAATAGC |
TGGGATTACA |
GGTGCCCACC |
ATCACGCCCG |
GCTAAGTTTT |
GTATTTTTAG |
TAGAGGCGGA |
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3841 |
GTTTCGCCAT |
GTTGGCCAGG |
CTGGTCTTGA |
ACCCCTAACC |
TCAGGTGATC |
CACCGACCTC |
GGCCTCCCAA |
AGTACTGGGA |
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3921 |
TTATTACAGG |
TGTGAGCCAC |
TGTACCCAGC |
CAATGATTAG |
CATTCTCACT |
AATAATAGCA |
TCTGAGCTGG |
CTCCTAGAGT |
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4001 |
ACAAGAAAAA |
GGAGTTCACA |
GTACTTTAAA |
ATAGATAAAA |
TTCAGTTGAG |
TTAGTAACCT |
AACTCATTGT |
TAGTACTAGT |
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4081 |
TGCTGCTCCT |
TGTAGACCAA |
TATGAAATTA |
CTTTTAGCTC |
GATAAAACCA |
AAAGTGTCAC |
TTTATGCTTC |
AGACTGAAAT |
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4161 |
GCGGGGATCT |
AGATGTGCTA |
ATGCTTGTCA |
GTAACAACTA |
ACAAGTTTTT |
CTGTATGTAA |
CTTCTAGGTG |
AAAGACCCCT |
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4241 |
GACAAAAGAC |
AATCATCTTC |
TGGGTACATT |
TGATCTGACT |
GGAATTCCTC |
CTGCTCCTCG |
TGGGGTCCCA |
CAGATTGAAG |
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4321 |
TCACCTTTGA |
GATAGATGTG |
AATGGTATTC |
TTCGAGTGAC |
AGCTGAAGAC |
AAGGGTACAG |
GGAACAAAAA |
TAAGATCACA |
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4401 |
ATCACCAATG |
ACCAGAATCG |
CCTGACACCT |
GAAGAAATCG |
AAAGGATGGT |
TAATGATGCT |
GAGAAGTTTG |
CTGAGGAAGA |
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4481 |
CAAAAAGCTC |
AAGGAGCGCA |
TTGATACTAG |
AAATGAGTTG |
GAAAGCTATG |
CCTATTCTCT |
AAAGAATCAG |
ATTGGAGATA |
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4561 |
AAGAAAAGCT |
GGGAGGTAAA |
CTTTCCTCTG |
AAGATAAGGA |
GACCATGGAA |
AAAGCTGTAG |
AAGAAAAGAT |
TGAATGGCTG |
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4641 |
GAAAGCCACC |
AAGATGCTGA |
CATTGAAGAC |
TTCAAAGCTA |
AGAAGAAGGA |
ACTGGAAGAA |
ATTGTTCAAC |
CAATTATCAG |
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4721 |
CAAACTCTAT |
GGAAGTGCAG |
GCCCTCCCCC |
AACTGGTGAA |
GAGGATACAG |
CAGAAAAAGA |
TGAGTTGTAG |
ACACTGATCT |
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4801 |
GCTAGTGCTG |
TAATATTGTA |
AATACTGGAC |
TCAGGAACTT |
TTGTTAGGAA |
AAAATTGAAA |
GAACTTAAGT |
CTCGAATGTA |
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4881 |
ATTGGAATCT |
TCACCTCAGA |
GTGGAGTTGA |
AACTGCTATA |
GCCTAAGCGG |
CTGTTTACTG |
CTTTTCATTA |
GCAGTTGCTC |
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4961 |
ACATGTCTTT |
GGGTGGGGGG |
GAGAAGAAGA |
ATTGGCCATC |
TTAAAAAGCG |
GGTAAAAAAC |
CTGGGTTAGG |
GTGTGTGTTC |
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5041 |
ACCTTCAAAA |
TGTTCTATTT |
AACAACTGGG |
TCATGTGCAT |
CTGGTGTAGG |
AAGTTTTTTC |
TACCATAAGT |
GACACCAATA |
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5121 |
AATGTTTGTT |
ATTTACACTG |
GTCTAATGTT |
TGTGAGAAGC |
TTCTAATTAG |
ATCAATTACT |
TATTTTAGGA |
AATTTAAGAC |
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5201 |
TAGATACTCG |
TGTGTGGGGT |
GAGGGGAGGG |
AGTATTTGGT |
ATGTTGGGAT |
AAGGAAACAC |
TTCTATTTAA |
TGCTTCCAGG |
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5281 |
GATTTTTTTT |
TTTTTTTTTA |
ACCCTCCTGG |
GCCCAAGTGA |
TCCTTCCACC |
TCAGTCTCCC |
AGCTAATTGA |
GACCACAGGC |
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5361 |
TTGTTACCAC |
CATGCTCGGC |
TTTTGCATTA |
ATCTAAGAAA |
AGGGGAGAGA |
AGTTAATCCA |
CATCTTTACT |
CAGGCAAGGG |
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5441 |
GCATTTCACA |
GTGCCCAAGA |
GTGGGGTTTT |
CTTGAACATA |
CTTGGTTTCC |
TATTTCCCCT |
TATCTTTCTA |
AAACTGCCTT |
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5521 |
TCTGGTGGCT |
TTTTTTAAAA |
TTATTACTAA |
TGATGCTTTT |
ATAGCTGCTT |
GGATTCTCTG |
AGAAATGATG |
GGGAGTGAGT |
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5601 |
GATCACTGGT |
ATTAACTTTA |
TACACTTGGA |
TTTCATTTGT |
AACTTTAGGA |
TGTAAAGGTA |
TATTGTGAAC |
CCTAGCTGTG |
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5681 |
TCAGAATCTC |
CATCCCTGAA |
ATTTCTCATT |
AGTGGTACTG |
GGGTGGGATC |
TTGGATGGTG |
ACATTGAAAC |
TACACTAAAT |
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5761 |
CCCCTCACTA |
TGAATGGGTT |
GTTAAAGGCA |
ATGGTTTGTG |
TCAAAACTGG |
TTTAGGATTA |
CTTAGATTGT |
GTTCCTGAAG |
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5841 |
AAAAGAGTCC |
AGGTAAATGG |
TATGATCAAT |
AAAGGACAGG |
CTGGTGCTAA |
CATAAAATCC |
AATATTGTAA |
TCCTAGCACT |
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5921 |
TTGGGAGGCC |
AAGGCGGGTG |
GATCACAAGG |
TCAAGAGATA |
GAGACCATCT |
TTGCCAACAT |
GGTGAAACTC |
CATCTCTACT |
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6001 |
GAAAATACAA |
AAATTAGCTG |
GGCGTGGTAG |
TGCAAGCTGA |
AGGCTGAGGC |
AGGAGAATCA |
CTCGAACCCG |
GGAGGCAGAG |
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6081 |
GTTGCAGTGA |
GCCGAGATCA |
CACCACTGTA |
CTCCAGCCCG |
GCACTCCAGC |
CTGGCGACAA |
GAGTGAGACT |
CCACCTCAAA |
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6161 |
AAAAAAAAAA |
AGAATCCAAT |
ACTGCCCAAG |
GATAGGTATT |
TTATAGATGG |
GCAACTGGCT |
GAAAGGTTAA |
TTCTCTAGGG |
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6241 |
CTAGTAGAAC |
TGGATCCCAA |
CACCAAACTC |
TTAATTAGAC |
CTAGGCCTCA |
GCTGCACTGC |
CCGAAAAGCA |
TTTGGGCAGA |
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6321 |
CCCTGAGCAG |
AATACTGGTC |
TCAGGCCAAG |
CCCAATACAG |
CCATTAAAGA |
TGACCTACAG |
TGCTGTGTAC |
CCTGGGGCAA |
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6401 |
TAGGGTTAAA |
TGGTAGTTAG |
CAACTAGGGC |
TAGTCTTCCC |
TTACCTCAAA |
GGCTCTCACT |
ACCGTGGACC |
ACCTAGTCTG |
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6481 |
TAACTCTTTC |
TGAGGAGCTG |
TTACTGAATA |
TTAAAAAGAT |
AGACTTCAAC |
TATGT |
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>ref|Gene_ID:3309|HSPA5|NC_000009.11:127997126...128003660 (-)
GGGGAGGGTATATAAGCCGAGTAGGCGACGGTGAGGTCGACGCCGGCCAAGACAGCACAGACAGATTGACCTATTGGGGT
GTTTCGCGAGTGTGAGAGGGAAGCGCCGCGGCCTGTATTTCTAGACCTGCCCTTCGCCTGGTTCGTGGCGCCTTGTGACC
CCGGGCCCCTGCCGCCTGCAAGTCGGAAATTGCGCTGTGCTCCTGTGCTACGGCCTGTGGCTGGACTGCCTGCTGCTGCC
CAACTGGCTGGCAAGATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTCAGCGCGGCGCGGGCCGAGGAGGAGGA
CAAGAAGGAGGACGTGGGCACGGTGGTCGGCATCGACCTGGGGACCACCTACTCCTGGTAAGTGGGGTTGCGGATGCAGG
GGGACGGGGCGTGGCCGCCTGGCCTGGCGTGAGAAGTGCGGTGCTGATGTCCCTCTGTCGGGTTTTTCTGCCAGCGTCGG
CGTGTTCAAGAACGGCCGCGTGGAGATCATCGCCAACGATCAGGGCAACCGCATCACGCCGTCCTATGTCGCCTTCACTC
CTGAAGGGGAACGTCTGATTGGCGATGCCGCCAAGAACCAGCTCACCTCCAACCCCGAGAACACGGTCTTTGACGCCAAG
CGGCTCATCGGCCGCACGTGGAATGACCCGTCTGTGCAGCAGGACATCAAGTTCTTGCCGTTCAAGGTTCGACCGGGTTT
TTCTCATCCAGTTAGAGAACGGGTGGGTGGTGGGAGTATTTAGAGTTATAAGTCTCTGGAAAAGTGTTGAGACAACAGTT
GAAGGTTATAGACATGATGTATGTAATAACTTTAATACTATTAGTATGTTACAAAACTTAAGACAGTTGCTGTCGTACTG
TCTACGATAGTTTAGGAATAAAAGACCGATTAAAACTGAACTTTGTAAGACACCTATACTCCCTGAAGTATTTCTAGTCA
ATTTGCAGCCCCAAGGGACCAAAATAAACCAAATTGTGGGGATGGTAGTGGGTCTTTTAAACTTTGAGATGTCATTGTAT
CTGTGTCTGAAAACAATAATTCTTTAAAATAGGTGGTTGAAAAGAAAACTAAACCATACATTCAAGTTGATATTGGAGGT
GGGCAAACAAAGACATTTGCTCCTGAAGAAATTTCTGCCATGGTTCTCACTAAAATGAAAGAAACCGCTGAGGCTTATTT
GGGAAAGAAGGTAAATATTTCTAGAACAATGTTAAGTATTTTTTGATCATTAGTATTCTCGGTTGGCTGTTATGTATAGA
AGCCTTCGTGAAGGGTTTCAAAAATTTTAATCAGAATGGTATTCATGCTTGTCAGGTTTAATTATTGAGTCCCTTACTAT
AAGCCAAACAAAATAGACTTTTCATGTATTATTTAATGCTTACAATTCCAGGGACATAAAATTTTATATGTTGTATTCAT
CAATAAGTTGGCTTAAAAACTAAAGTGATGGTTTGACTGTAATTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCA
GGCTGGACTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAGCTCTCCTGCCTCAGCCTCC
CAAGTAACTGGAACTACAGGCACACCACCACACCTGGCTAATTTTTTTTTTTTTTTTTAATTTTCAGTAGAGACAGGGTT
TCTCCACATTGCCCAGGCTGGTCTTGAAATCCTGCCCTCAGGTGATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTA
TAGGCAGAAGCCACCGCCTGGCCAGACTGTAATTTAAATAAGGGTTAAACTATGTGACAATACACTTAATTATCTTTTAT
CCTTTTAGGTTACCCATGCAGTTGTTACTGTACCAGCCTATTTTAATGATGCCCAACGCCAAGCAACCAAAGACGCTGGA
ACTATTGCTGGCCTAAATGTTATGAGGATCATCAACGAGCCGTAAGTATGAAATTCAGGGATACGGCATATTTGCCAAAT
AGTGGAAATGTGAAGTACTGACAAAACTTTTCCCTTTTTCAATCTAATAGTACGGCAGCTGCTATTGCTTATGGCCTGGA
TAAGAGGGAGGGGGAGAAGAACATCCTGGTGTTTGACCTGGGTGGCGGAACCTTCGATGTGTCTCTTCTCACCATTGACA
ATGGTGTCTTCGAAGTTGTGGCCACTAATGGAGATACTCATCTGGGTGGAGAAGACTTTGACCAGCGTGTCATGGAACAC
TTCATCAAACTGTACAAAAAGAAGACGGGCAAAGATGTCAGGAAAGACAATAGAGCTGTGCAGAAACTCCGGCGCGAGGT
AGAAAAGGCCAAACGGGCCCTGTCTTCTCAGCATCAAGCAAGAATTGAAATTGAGTCCTTCTATGAAGGAGAAGACTTTT
CTGAGACCCTGACTCGGGCCAAATTTGAAGAGCTCAACATGGTATGTTCCTTGTTTTCTGCTTTGCTAATGAGATCTCCT
TAGACTCTGAATTCAGGACATTGCATCTAGATACTTAGATAACAGACATCACAGTAACCATGTCTTTTTTCTAGGATCTG
TTCCGGTCTACTATGAAGCCCGTCCAGAAAGTGTTGGAAGATTCTGATTTGAAGAAGTCTGATATTGATGAAATTGTTCT
TGTTGGTGGCTCGACTCGAATTCCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAATGGCAAGGAACCATCCCGTGGCA
TAAACCCAGATGAAGCTGTAGCGTATGGTGCTGCTGTCCAGGCTGGTGTGCTCTCTGGTGATCAAGATACAGGTAGGTCA
TCATCGCAGCATCTTTCTTAGTGATTCAGTAGCTTGATGGAAGACTCATTAGCTATTGCTTTAGAAAATACCAGAATATG
AGCAACAAGGTCACACAGCTAGTAAAGGGTATAAGTGAAGACAAGACTGGGGTAGTCTCAAGATCATTAGCAACTGTTTA
ATTCACTGCCTTTAAAATGTGTGTGTTAGAACCTAACCAAATGTTAGAGAGATAAACTTTACATAGCTCATAGGGAGAAC
TTGAATTAAAAGTTAAATAACTTATCCTTACAGGTGACCTGGTACTGCTTGATGTATGTCCCCTTACACTTGGTATTGAA
ACTGTGGGAGGTGTCATGACCAAACTGATTCCAAGGAACACAGTGGTGCCTACCAAGAAGTCTCAGATCTTTTCTACAGC
TTCTGATAATCAACCAACTGTTACAATCAAGGTCTATGAAGGTAATTACTTAAGTTTGTTAATATCATGGCTTTTTTTTT
GAGATGAAGTCTTGCTCTGTTGCCCAGGCTGGACTGCAGTGGCACGATCTCGGCTCACTGCAAATTCTGTCTCCCGGGTT
CAAGTGATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGCGTGGACCACCACACCTGGCTAATTTCTGTATTT
TTAGTAGAGATGGGGTTTCACCATGTTTCCCAGGCTGGTCTCCAACTCCTGACCTCAGGTCATCTGCCTGCCTCCACCTC
CCAAAGTGCTGGGATTATAGGCGTGAGCCACCACGCCAGATCTATCTATCATGGCATATTTTAAAAGAACATGACTTAAT
ATGTCCTATTGAAATGGCTAGGGAACTAAGTAACTGCTGTTTTCAGATGGAGGTCTTAATTTGAATAATGTTGATATTAG
ATATTTAGCATTCTTTTTTTTTTTTTTTTAATGGAGTCTTGCTCTGTCGCCTAGGCTGGGGTGCAGTGGCATGACTTGCA
ACCTCTGCCTCCCGAATAGCTGGGATTACAGGTGCCCACCATCACGCCCGGCTAAGTTTTGTATTTTTAGTAGAGGCGGA
GTTTCGCCATGTTGGCCAGGCTGGTCTTGAACCCCTAACCTCAGGTGATCCACCGACCTCGGCCTCCCAAAGTACTGGGA
TTATTACAGGTGTGAGCCACTGTACCCAGCCAATGATTAGCATTCTCACTAATAATAGCATCTGAGCTGGCTCCTAGAGT
ACAAGAAAAAGGAGTTCACAGTACTTTAAAATAGATAAAATTCAGTTGAGTTAGTAACCTAACTCATTGTTAGTACTAGT
TGCTGCTCCTTGTAGACCAATATGAAATTACTTTTAGCTCGATAAAACCAAAAGTGTCACTTTATGCTTCAGACTGAAAT
GCGGGGATCTAGATGTGCTAATGCTTGTCAGTAACAACTAACAAGTTTTTCTGTATGTAACTTCTAGGTGAAAGACCCCT
GACAAAAGACAATCATCTTCTGGGTACATTTGATCTGACTGGAATTCCTCCTGCTCCTCGTGGGGTCCCACAGATTGAAG
TCACCTTTGAGATAGATGTGAATGGTATTCTTCGAGTGACAGCTGAAGACAAGGGTACAGGGAACAAAAATAAGATCACA
ATCACCAATGACCAGAATCGCCTGACACCTGAAGAAATCGAAAGGATGGTTAATGATGCTGAGAAGTTTGCTGAGGAAGA
CAAAAAGCTCAAGGAGCGCATTGATACTAGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAATCAGATTGGAGATA
AAGAAAAGCTGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAGCTGTAGAAGAAAAGATTGAATGGCTG
GAAAGCCACCAAGATGCTGACATTGAAGACTTCAAAGCTAAGAAGAAGGAACTGGAAGAAATTGTTCAACCAATTATCAG
CAAACTCTATGGAAGTGCAGGCCCTCCCCCAACTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTGTAGACACTGATCT
GCTAGTGCTGTAATATTGTAAATACTGGACTCAGGAACTTTTGTTAGGAAAAAATTGAAAGAACTTAAGTCTCGAATGTA
ATTGGAATCTTCACCTCAGAGTGGAGTTGAAACTGCTATAGCCTAAGCGGCTGTTTACTGCTTTTCATTAGCAGTTGCTC
ACATGTCTTTGGGTGGGGGGGAGAAGAAGAATTGGCCATCTTAAAAAGCGGGTAAAAAACCTGGGTTAGGGTGTGTGTTC
ACCTTCAAAATGTTCTATTTAACAACTGGGTCATGTGCATCTGGTGTAGGAAGTTTTTTCTACCATAAGTGACACCAATA
AATGTTTGTTATTTACACTGGTCTAATGTTTGTGAGAAGCTTCTAATTAGATCAATTACTTATTTTAGGAAATTTAAGAC
TAGATACTCGTGTGTGGGGTGAGGGGAGGGAGTATTTGGTATGTTGGGATAAGGAAACACTTCTATTTAATGCTTCCAGG
GATTTTTTTTTTTTTTTTTAACCCTCCTGGGCCCAAGTGATCCTTCCACCTCAGTCTCCCAGCTAATTGAGACCACAGGC
TTGTTACCACCATGCTCGGCTTTTGCATTAATCTAAGAAAAGGGGAGAGAAGTTAATCCACATCTTTACTCAGGCAAGGG
GCATTTCACAGTGCCCAAGAGTGGGGTTTTCTTGAACATACTTGGTTTCCTATTTCCCCTTATCTTTCTAAAACTGCCTT
TCTGGTGGCTTTTTTTAAAATTATTACTAATGATGCTTTTATAGCTGCTTGGATTCTCTGAGAAATGATGGGGAGTGAGT
GATCACTGGTATTAACTTTATACACTTGGATTTCATTTGTAACTTTAGGATGTAAAGGTATATTGTGAACCCTAGCTGTG
TCAGAATCTCCATCCCTGAAATTTCTCATTAGTGGTACTGGGGTGGGATCTTGGATGGTGACATTGAAACTACACTAAAT
CCCCTCACTATGAATGGGTTGTTAAAGGCAATGGTTTGTGTCAAAACTGGTTTAGGATTACTTAGATTGTGTTCCTGAAG
AAAAGAGTCCAGGTAAATGGTATGATCAATAAAGGACAGGCTGGTGCTAACATAAAATCCAATATTGTAATCCTAGCACT
TTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAAGAGATAGAGACCATCTTTGCCAACATGGTGAAACTCCATCTCTACT
GAAAATACAAAAATTAGCTGGGCGTGGTAGTGCAAGCTGAAGGCTGAGGCAGGAGAATCACTCGAACCCGGGAGGCAGAG
GTTGCAGTGAGCCGAGATCACACCACTGTACTCCAGCCCGGCACTCCAGCCTGGCGACAAGAGTGAGACTCCACCTCAAA
AAAAAAAAAAAGAATCCAATACTGCCCAAGGATAGGTATTTTATAGATGGGCAACTGGCTGAAAGGTTAATTCTCTAGGG
CTAGTAGAACTGGATCCCAACACCAAACTCTTAATTAGACCTAGGCCTCAGCTGCACTGCCCGAAAAGCATTTGGGCAGA
CCCTGAGCAGAATACTGGTCTCAGGCCAAGCCCAATACAGCCATTAAAGATGACCTACAGTGCTGTGTACCCTGGGGCAA
TAGGGTTAAATGGTAGTTAGCAACTAGGGCTAGTCTTCCCTTACCTCAAAGGCTCTCACTACCGTGGACCACCTAGTCTG
TAACTCTTTCTGAGGAGCTGTTACTGAATATTAAAAAGATAGACTTCAACTATGT
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Primary source |
RefSeq : NM_005347.3 (GI:194097371)
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Name |
Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5)
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
3965 nt
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Map |
9q33-q34.1
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Location |
Chromosome 9 (NC_000009.11) strand : -
127997126...127999432 | 128000419...128000586 | 128000868...128001105 | 128001219...128001609 |
128001699...128001811 | 128002450...128002587 | 128002954...128003185 | 128003283...128003660 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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378
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378
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1
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Exon 2
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379
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610
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232
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1
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Exon 3
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611
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748
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138
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1
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Exon 4
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749
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861
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113
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1
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Exon 5
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862
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1252
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391
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1
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Exon 6
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1253
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1490
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238
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1
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Exon 7
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1491
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1658
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168
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1
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Exon 8
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1659
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3965
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2307
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1
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Primary source |
NCBI : CCDS6863
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Nucleotide |
HSPA5, mRNA isoform 1[NM_005347.3] : 257...2221
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Length |
1965
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Location |
Chromosome 9 (NC_000009.11) strand : -
127998870...127999432 | 128000419...128000586 | 128000868...128001105 | 128001219...128001609 |
128001699...128001811 | 128002450...128002587 | 128002954...128003185 | 128003283...128003404 |
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Start codon |
1
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Translation |
NP_005338.1 |
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1 |
GGGGGAGGGT |
ATATAAGCCG |
AGTAGGCGAC |
GGTGAGGTCG |
ACGCCGGCCA |
AGACAGCACA |
GACAGATTGA |
CCTATTGGGG |
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81 |
TGTTTCGCGA |
GTGTGAGAGG |
GAAGCGCCGC |
GGCCTGTATT |
TCTAGACCTG |
CCCTTCGCCT |
GGTTCGTGGC |
GCCTTGTGAC |
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161 |
CCCGGGCCCC |
TGCCGCCTGC |
AAGTCGGAAA |
TTGCGCTGTG |
CTCCTGTGCT |
ACGGCCTGTG |
GCTGGACTGC |
CTGCTGCTGC |
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241 |
CCAACTGGCT |
GGCAAGATGA |
AGCTCTCCCT |
GGTGGCCGCG |
ATGCTGCTGC |
TGCTCAGCGC |
GGCGCGGGCC |
GAGGAGGAGG |
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321 |
ACAAGAAGGA |
GGACGTGGGC |
ACGGTGGTCG |
GCATCGACCT |
GGGGACCACC |
TACTCCTGCG |
TCGGCGTGTT |
CAAGAACGGC |
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401 |
CGCGTGGAGA |
TCATCGCCAA |
CGATCAGGGC |
AACCGCATCA |
CGCCGTCCTA |
TGTCGCCTTC |
ACTCCTGAAG |
GGGAACGTCT |
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481 |
GATTGGCGAT |
GCCGCCAAGA |
ACCAGCTCAC |
CTCCAACCCC |
GAGAACACGG |
TCTTTGACGC |
CAAGCGGCTC |
ATCGGCCGCA |
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561 |
CGTGGAATGA |
CCCGTCTGTG |
CAGCAGGACA |
TCAAGTTCTT |
GCCGTTCAAG |
GTGGTTGAAA |
AGAAAACTAA |
ACCATACATT |
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641 |
CAAGTTGATA |
TTGGAGGTGG |
GCAAACAAAG |
ACATTTGCTC |
CTGAAGAAAT |
TTCTGCCATG |
GTTCTCACTA |
AAATGAAAGA |
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721 |
AACCGCTGAG |
GCTTATTTGG |
GAAAGAAGGT |
TACCCATGCA |
GTTGTTACTG |
TACCAGCCTA |
TTTTAATGAT |
GCCCAACGCC |
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801 |
AAGCAACCAA |
AGACGCTGGA |
ACTATTGCTG |
GCCTAAATGT |
TATGAGGATC |
ATCAACGAGC |
CTACGGCAGC |
TGCTATTGCT |
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881 |
TATGGCCTGG |
ATAAGAGGGA |
GGGGGAGAAG |
AACATCCTGG |
TGTTTGACCT |
GGGTGGCGGA |
ACCTTCGATG |
TGTCTCTTCT |
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961 |
CACCATTGAC |
AATGGTGTCT |
TCGAAGTTGT |
GGCCACTAAT |
GGAGATACTC |
ATCTGGGTGG |
AGAAGACTTT |
GACCAGCGTG |
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1041 |
TCATGGAACA |
CTTCATCAAA |
CTGTACAAAA |
AGAAGACGGG |
CAAAGATGTC |
AGGAAAGACA |
ATAGAGCTGT |
GCAGAAACTC |
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1121 |
CGGCGCGAGG |
TAGAAAAGGC |
CAAACGGGCC |
CTGTCTTCTC |
AGCATCAAGC |
AAGAATTGAA |
ATTGAGTCCT |
TCTATGAAGG |
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1201 |
AGAAGACTTT |
TCTGAGACCC |
TGACTCGGGC |
CAAATTTGAA |
GAGCTCAACA |
TGGATCTGTT |
CCGGTCTACT |
ATGAAGCCCG |
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1281 |
TCCAGAAAGT |
GTTGGAAGAT |
TCTGATTTGA |
AGAAGTCTGA |
TATTGATGAA |
ATTGTTCTTG |
TTGGTGGCTC |
GACTCGAATT |
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1361 |
CCAAAGATTC |
AGCAACTGGT |
TAAAGAGTTC |
TTCAATGGCA |
AGGAACCATC |
CCGTGGCATA |
AACCCAGATG |
AAGCTGTAGC |
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1441 |
GTATGGTGCT |
GCTGTCCAGG |
CTGGTGTGCT |
CTCTGGTGAT |
CAAGATACAG |
GTGACCTGGT |
ACTGCTTGAT |
GTATGTCCCC |
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1521 |
TTACACTTGG |
TATTGAAACT |
GTGGGAGGTG |
TCATGACCAA |
ACTGATTCCA |
AGGAACACAG |
TGGTGCCTAC |
CAAGAAGTCT |
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1601 |
CAGATCTTTT |
CTACAGCTTC |
TGATAATCAA |
CCAACTGTTA |
CAATCAAGGT |
CTATGAAGGT |
GAAAGACCCC |
TGACAAAAGA |
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1681 |
CAATCATCTT |
CTGGGTACAT |
TTGATCTGAC |
TGGAATTCCT |
CCTGCTCCTC |
GTGGGGTCCC |
ACAGATTGAA |
GTCACCTTTG |
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1761 |
AGATAGATGT |
GAATGGTATT |
CTTCGAGTGA |
CAGCTGAAGA |
CAAGGGTACA |
GGGAACAAAA |
ATAAGATCAC |
AATCACCAAT |
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1841 |
GACCAGAATC |
GCCTGACACC |
TGAAGAAATC |
GAAAGGATGG |
TTAATGATGC |
TGAGAAGTTT |
GCTGAGGAAG |
ACAAAAAGCT |
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1921 |
CAAGGAGCGC |
ATTGATACTA |
GAAATGAGTT |
GGAAAGCTAT |
GCCTATTCTC |
TAAAGAATCA |
GATTGGAGAT |
AAAGAAAAGC |
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2001 |
TGGGAGGTAA |
ACTTTCCTCT |
GAAGATAAGG |
AGACCATGGA |
AAAAGCTGTA |
GAAGAAAAGA |
TTGAATGGCT |
GGAAAGCCAC |
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2081 |
CAAGATGCTG |
ACATTGAAGA |
CTTCAAAGCT |
AAGAAGAAGG |
AACTGGAAGA |
AATTGTTCAA |
CCAATTATCA |
GCAAACTCTA |
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2161 |
TGGAAGTGCA |
GGCCCTCCCC |
CAACTGGTGA |
AGAGGATACA |
GCAGAAAAAG |
ATGAGTTGTA |
GACACTGATC |
TGCTAGTGCT |
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2241 |
GTAATATTGT |
AAATACTGGA |
CTCAGGAACT |
TTTGTTAGGA |
AAAAATTGAA |
AGAACTTAAG |
TCTCGAATGT |
AATTGGAATC |
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2321 |
TTCACCTCAG |
AGTGGAGTTG |
AAACTGCTAT |
AGCCTAAGCG |
GCTGTTTACT |
GCTTTTCATT |
AGCAGTTGCT |
CACATGTCTT |
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2401 |
TGGGTGGGGG |
GGAGAAGAAG |
AATTGGCCAT |
CTTAAAAAGC |
GGGTAAAAAA |
CCTGGGTTAG |
GGTGTGTGTT |
CACCTTCAAA |
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2481 |
ATGTTCTATT |
TAACAACTGG |
GTCATGTGCA |
TCTGGTGTAG |
GAAGTTTTTT |
CTACCATAAG |
TGACACCAAT |
AAATGTTTGT |
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2561 |
TATTTACACT |
GGTCTAATGT |
TTGTGAGAAG |
CTTCTAATTA |
GATCAATTAC |
TTATTTTAGG |
AAATTTAAGA |
CTAGATACTC |
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2641 |
GTGTGTGGGG |
TGAGGGGAGG |
GAGTATTTGG |
TATGTTGGGA |
TAAGGAAACA |
CTTCTATTTA |
ATGCTTCCAG |
GGATTTTTTT |
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2721 |
TTTTTTTTTT |
AACCCTCCTG |
GGCCCAAGTG |
ATCCTTCCAC |
CTCAGTCTCC |
CAGCTAATTG |
AGACCACAGG |
CTTGTTACCA |
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2801 |
CCATGCTCGG |
CTTTTGCATT |
AATCTAAGAA |
AAGGGGAGAG |
AAGTTAATCC |
ACATCTTTAC |
TCAGGCAAGG |
GGCATTTCAC |
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2881 |
AGTGCCCAAG |
AGTGGGGTTT |
TCTTGAACAT |
ACTTGGTTTC |
CTATTTCCCC |
TTATCTTTCT |
AAAACTGCCT |
TTCTGGTGGC |
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2961 |
TTTTTTTAAA |
ATTATTACTA |
ATGATGCTTT |
TATAGCTGCT |
TGGATTCTCT |
GAGAAATGAT |
GGGGAGTGAG |
TGATCACTGG |
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3041 |
TATTAACTTT |
ATACACTTGG |
ATTTCATTTG |
TAACTTTAGG |
ATGTAAAGGT |
ATATTGTGAA |
CCCTAGCTGT |
GTCAGAATCT |
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3121 |
CCATCCCTGA |
AATTTCTCAT |
TAGTGGTACT |
GGGGTGGGAT |
CTTGGATGGT |
GACATTGAAA |
CTACACTAAA |
TCCCCTCACT |
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3201 |
ATGAATGGGT |
TGTTAAAGGC |
AATGGTTTGT |
GTCAAAACTG |
GTTTAGGATT |
ACTTAGATTG |
TGTTCCTGAA |
GAAAAGAGTC |
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3281 |
CAGGTAAATG |
GTATGATCAA |
TAAAGGACAG |
GCTGGTGCTA |
ACATAAAATC |
CAATATTGTA |
ATCCTAGCAC |
TTTGGGAGGC |
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3361 |
CAAGGCGGGT |
GGATCACAAG |
GTCAAGAGAT |
AGAGACCATC |
TTTGCCAACA |
TGGTGAAACT |
CCATCTCTAC |
TGAAAATACA |
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3441 |
AAAATTAGCT |
GGGCGTGGTA |
GTGCAAGCTG |
AAGGCTGAGG |
CAGGAGAATC |
ACTCGAACCC |
GGGAGGCAGA |
GGTTGCAGTG |
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3521 |
AGCCGAGATC |
ACACCACTGT |
ACTCCAGCCC |
GGCACTCCAG |
CCTGGCGACA |
AGAGTGAGAC |
TCCACCTCAA |
AAAAAAAAAA |
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3601 |
AAGAATCCAA |
TACTGCCCAA |
GGATAGGTAT |
TTTATAGATG |
GGCAACTGGC |
TGAAAGGTTA |
ATTCTCTAGG |
GCTAGTAGAA |
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3681 |
CTGGATCCCA |
ACACCAAACT |
CTTAATTAGA |
CCTAGGCCTC |
AGCTGCACTG |
CCCGAAAAGC |
ATTTGGGCAG |
ACCCTGAGCA |
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3761 |
GAATACTGGT |
CTCAGGCCAA |
GCCCAATACA |
GCCATTAAAG |
ATGACCTACA |
GTGCTGTGTA |
CCCTGGGGCA |
ATAGGGTTAA |
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3841 |
ATGGTAGTTA |
GCAACTAGGG |
CTAGTCTTCC |
CTTACCTCAA |
AGGCTCTCAC |
TACCGTGGAC |
CACCTAGTCT |
GTAACTCTTT |
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3921 |
CTGAGGAGCT |
GTTACTGAAT |
ATTAAAAAGA |
TAGACTTCAA |
CTATG |
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>gi|194097371|ref|NM_005347.3|Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5)
GGGGGAGGGTATATAAGCCGAGTAGGCGACGGTGAGGTCGACGCCGGCCAAGACAGCACAGACAGATTGACCTATTGGGG
TGTTTCGCGAGTGTGAGAGGGAAGCGCCGCGGCCTGTATTTCTAGACCTGCCCTTCGCCTGGTTCGTGGCGCCTTGTGAC
CCCGGGCCCCTGCCGCCTGCAAGTCGGAAATTGCGCTGTGCTCCTGTGCTACGGCCTGTGGCTGGACTGCCTGCTGCTGC
CCAACTGGCTGGCAAGATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTCAGCGCGGCGCGGGCCGAGGAGGAGG
ACAAGAAGGAGGACGTGGGCACGGTGGTCGGCATCGACCTGGGGACCACCTACTCCTGCGTCGGCGTGTTCAAGAACGGC
CGCGTGGAGATCATCGCCAACGATCAGGGCAACCGCATCACGCCGTCCTATGTCGCCTTCACTCCTGAAGGGGAACGTCT
GATTGGCGATGCCGCCAAGAACCAGCTCACCTCCAACCCCGAGAACACGGTCTTTGACGCCAAGCGGCTCATCGGCCGCA
CGTGGAATGACCCGTCTGTGCAGCAGGACATCAAGTTCTTGCCGTTCAAGGTGGTTGAAAAGAAAACTAAACCATACATT
CAAGTTGATATTGGAGGTGGGCAAACAAAGACATTTGCTCCTGAAGAAATTTCTGCCATGGTTCTCACTAAAATGAAAGA
AACCGCTGAGGCTTATTTGGGAAAGAAGGTTACCCATGCAGTTGTTACTGTACCAGCCTATTTTAATGATGCCCAACGCC
AAGCAACCAAAGACGCTGGAACTATTGCTGGCCTAAATGTTATGAGGATCATCAACGAGCCTACGGCAGCTGCTATTGCT
TATGGCCTGGATAAGAGGGAGGGGGAGAAGAACATCCTGGTGTTTGACCTGGGTGGCGGAACCTTCGATGTGTCTCTTCT
CACCATTGACAATGGTGTCTTCGAAGTTGTGGCCACTAATGGAGATACTCATCTGGGTGGAGAAGACTTTGACCAGCGTG
TCATGGAACACTTCATCAAACTGTACAAAAAGAAGACGGGCAAAGATGTCAGGAAAGACAATAGAGCTGTGCAGAAACTC
CGGCGCGAGGTAGAAAAGGCCAAACGGGCCCTGTCTTCTCAGCATCAAGCAAGAATTGAAATTGAGTCCTTCTATGAAGG
AGAAGACTTTTCTGAGACCCTGACTCGGGCCAAATTTGAAGAGCTCAACATGGATCTGTTCCGGTCTACTATGAAGCCCG
TCCAGAAAGTGTTGGAAGATTCTGATTTGAAGAAGTCTGATATTGATGAAATTGTTCTTGTTGGTGGCTCGACTCGAATT
CCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAATGGCAAGGAACCATCCCGTGGCATAAACCCAGATGAAGCTGTAGC
GTATGGTGCTGCTGTCCAGGCTGGTGTGCTCTCTGGTGATCAAGATACAGGTGACCTGGTACTGCTTGATGTATGTCCCC
TTACACTTGGTATTGAAACTGTGGGAGGTGTCATGACCAAACTGATTCCAAGGAACACAGTGGTGCCTACCAAGAAGTCT
CAGATCTTTTCTACAGCTTCTGATAATCAACCAACTGTTACAATCAAGGTCTATGAAGGTGAAAGACCCCTGACAAAAGA
CAATCATCTTCTGGGTACATTTGATCTGACTGGAATTCCTCCTGCTCCTCGTGGGGTCCCACAGATTGAAGTCACCTTTG
AGATAGATGTGAATGGTATTCTTCGAGTGACAGCTGAAGACAAGGGTACAGGGAACAAAAATAAGATCACAATCACCAAT
GACCAGAATCGCCTGACACCTGAAGAAATCGAAAGGATGGTTAATGATGCTGAGAAGTTTGCTGAGGAAGACAAAAAGCT
CAAGGAGCGCATTGATACTAGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAATCAGATTGGAGATAAAGAAAAGC
TGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAGCTGTAGAAGAAAAGATTGAATGGCTGGAAAGCCAC
CAAGATGCTGACATTGAAGACTTCAAAGCTAAGAAGAAGGAACTGGAAGAAATTGTTCAACCAATTATCAGCAAACTCTA
TGGAAGTGCAGGCCCTCCCCCAACTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTGTAGACACTGATCTGCTAGTGCT
GTAATATTGTAAATACTGGACTCAGGAACTTTTGTTAGGAAAAAATTGAAAGAACTTAAGTCTCGAATGTAATTGGAATC
TTCACCTCAGAGTGGAGTTGAAACTGCTATAGCCTAAGCGGCTGTTTACTGCTTTTCATTAGCAGTTGCTCACATGTCTT
TGGGTGGGGGGGAGAAGAAGAATTGGCCATCTTAAAAAGCGGGTAAAAAACCTGGGTTAGGGTGTGTGTTCACCTTCAAA
ATGTTCTATTTAACAACTGGGTCATGTGCATCTGGTGTAGGAAGTTTTTTCTACCATAAGTGACACCAATAAATGTTTGT
TATTTACACTGGTCTAATGTTTGTGAGAAGCTTCTAATTAGATCAATTACTTATTTTAGGAAATTTAAGACTAGATACTC
GTGTGTGGGGTGAGGGGAGGGAGTATTTGGTATGTTGGGATAAGGAAACACTTCTATTTAATGCTTCCAGGGATTTTTTT
TTTTTTTTTTAACCCTCCTGGGCCCAAGTGATCCTTCCACCTCAGTCTCCCAGCTAATTGAGACCACAGGCTTGTTACCA
CCATGCTCGGCTTTTGCATTAATCTAAGAAAAGGGGAGAGAAGTTAATCCACATCTTTACTCAGGCAAGGGGCATTTCAC
AGTGCCCAAGAGTGGGGTTTTCTTGAACATACTTGGTTTCCTATTTCCCCTTATCTTTCTAAAACTGCCTTTCTGGTGGC
TTTTTTTAAAATTATTACTAATGATGCTTTTATAGCTGCTTGGATTCTCTGAGAAATGATGGGGAGTGAGTGATCACTGG
TATTAACTTTATACACTTGGATTTCATTTGTAACTTTAGGATGTAAAGGTATATTGTGAACCCTAGCTGTGTCAGAATCT
CCATCCCTGAAATTTCTCATTAGTGGTACTGGGGTGGGATCTTGGATGGTGACATTGAAACTACACTAAATCCCCTCACT
ATGAATGGGTTGTTAAAGGCAATGGTTTGTGTCAAAACTGGTTTAGGATTACTTAGATTGTGTTCCTGAAGAAAAGAGTC
CAGGTAAATGGTATGATCAATAAAGGACAGGCTGGTGCTAACATAAAATCCAATATTGTAATCCTAGCACTTTGGGAGGC
CAAGGCGGGTGGATCACAAGGTCAAGAGATAGAGACCATCTTTGCCAACATGGTGAAACTCCATCTCTACTGAAAATACA
AAAATTAGCTGGGCGTGGTAGTGCAAGCTGAAGGCTGAGGCAGGAGAATCACTCGAACCCGGGAGGCAGAGGTTGCAGTG
AGCCGAGATCACACCACTGTACTCCAGCCCGGCACTCCAGCCTGGCGACAAGAGTGAGACTCCACCTCAAAAAAAAAAAA
AAGAATCCAATACTGCCCAAGGATAGGTATTTTATAGATGGGCAACTGGCTGAAAGGTTAATTCTCTAGGGCTAGTAGAA
CTGGATCCCAACACCAAACTCTTAATTAGACCTAGGCCTCAGCTGCACTGCCCGAAAAGCATTTGGGCAGACCCTGAGCA
GAATACTGGTCTCAGGCCAAGCCCAATACAGCCATTAAAGATGACCTACAGTGCTGTGTACCCTGGGGCAATAGGGTTAA
ATGGTAGTTAGCAACTAGGGCTAGTCTTCCCTTACCTCAAAGGCTCTCACTACCGTGGACCACCTAGTCTGTAACTCTTT
CTGAGGAGCTGTTACTGAATATTAAAAAGATAGACTTCAACTATG
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Exon number |
1
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Length |
378 nt
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Location |
Chromosome 9 (NC_000009.11) : 128003283...128003660 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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GGGGGAGGGTATATAAGCCGAGTAGGCGACGGTGAGGTCGACGCCGGCCAAGACAGCACAGACAGATTGACCTATTGGGG
TGTTTCGCGAGTGTGAGAGGGAAGCGCCGCGGCCTGTATTTCTAGACCTGCCCTTCGCCTGGTTCGTGGCGCCTTGTGAC
CCCGGGCCCCTGCCGCCTGCAAGTCGGAAATTGCGCTGTGCTCCTGTGCTACGGCCTGTGGCTGGACTGCCTGCTGCTGC
CCAACTGGCTGGCAAGATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTCAGCGCGGCGCGGGCCGAGGAGGAGG
ACAAGAAGGAGGACGTGGGCACGGTGGTCGGCATCGACCTGGGGACCACCTACTCCTG
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Exon number |
2
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Length |
232 nt
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Location |
Chromosome 9 (NC_000009.11) : 128002954...128003185 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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CGTCGGCGTGTTCAAGAACGGCCGCGTGGAGATCATCGCCAACGATCAGGGCAACCGCATCACGCCGTCCTATGTCGCCT
TCACTCCTGAAGGGGAACGTCTGATTGGCGATGCCGCCAAGAACCAGCTCACCTCCAACCCCGAGAACACGGTCTTTGAC
GCCAAGCGGCTCATCGGCCGCACGTGGAATGACCCGTCTGTGCAGCAGGACATCAAGTTCTTGCCGTTCAAG
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Exon number |
3
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Length |
138 nt
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Location |
Chromosome 9 (NC_000009.11) : 128002450...128002587 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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GTGGTTGAAAAGAAAACTAAACCATACATTCAAGTTGATATTGGAGGTGGGCAAACAAAGACATTTGCTCCTGAAGAAAT
TTCTGCCATGGTTCTCACTAAAATGAAAGAAACCGCTGAGGCTTATTTGGGAAAGAAG
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Exon number |
4
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Length |
113 nt
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Location |
Chromosome 9 (NC_000009.11) : 128001699...128001811 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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GTTACCCATGCAGTTGTTACTGTACCAGCCTATTTTAATGATGCCCAACGCCAAGCAACCAAAGACGCTGGAACTATTGC
TGGCCTAAATGTTATGAGGATCATCAACGAGCC
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Exon number |
5
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Length |
391 nt
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Location |
Chromosome 9 (NC_000009.11) : 128001219...128001609 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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TACGGCAGCTGCTATTGCTTATGGCCTGGATAAGAGGGAGGGGGAGAAGAACATCCTGGTGTTTGACCTGGGTGGCGGAA
CCTTCGATGTGTCTCTTCTCACCATTGACAATGGTGTCTTCGAAGTTGTGGCCACTAATGGAGATACTCATCTGGGTGGA
GAAGACTTTGACCAGCGTGTCATGGAACACTTCATCAAACTGTACAAAAAGAAGACGGGCAAAGATGTCAGGAAAGACAA
TAGAGCTGTGCAGAAACTCCGGCGCGAGGTAGAAAAGGCCAAACGGGCCCTGTCTTCTCAGCATCAAGCAAGAATTGAAA
TTGAGTCCTTCTATGAAGGAGAAGACTTTTCTGAGACCCTGACTCGGGCCAAATTTGAAGAGCTCAACATG
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Exon number |
6
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Length |
238 nt
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Location |
Chromosome 9 (NC_000009.11) : 128000868...128001105 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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GATCTGTTCCGGTCTACTATGAAGCCCGTCCAGAAAGTGTTGGAAGATTCTGATTTGAAGAAGTCTGATATTGATGAAAT
TGTTCTTGTTGGTGGCTCGACTCGAATTCCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAATGGCAAGGAACCATCCC
GTGGCATAAACCCAGATGAAGCTGTAGCGTATGGTGCTGCTGTCCAGGCTGGTGTGCTCTCTGGTGATCAAGATACAG
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Exon number |
7
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Length |
168 nt
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Location |
Chromosome 9 (NC_000009.11) : 128000419...128000586 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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GTGACCTGGTACTGCTTGATGTATGTCCCCTTACACTTGGTATTGAAACTGTGGGAGGTGTCATGACCAAACTGATTCCA
AGGAACACAGTGGTGCCTACCAAGAAGTCTCAGATCTTTTCTACAGCTTCTGATAATCAACCAACTGTTACAATCAAGGT
CTATGAAG
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Exon number |
8
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Length |
2307 nt
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Location |
Chromosome 9 (NC_000009.11) : 127997126...127999432 (-)
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Is part of |
HSPA5, mRNA isoform 1
(NM_005347.3)
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Sequence |
Show
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GTGAAAGACCCCTGACAAAAGACAATCATCTTCTGGGTACATTTGATCTGACTGGAATTCCTCCTGCTCCTCGTGGGGTC
CCACAGATTGAAGTCACCTTTGAGATAGATGTGAATGGTATTCTTCGAGTGACAGCTGAAGACAAGGGTACAGGGAACAA
AAATAAGATCACAATCACCAATGACCAGAATCGCCTGACACCTGAAGAAATCGAAAGGATGGTTAATGATGCTGAGAAGT
TTGCTGAGGAAGACAAAAAGCTCAAGGAGCGCATTGATACTAGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAAT
CAGATTGGAGATAAAGAAAAGCTGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAGCTGTAGAAGAAAA
GATTGAATGGCTGGAAAGCCACCAAGATGCTGACATTGAAGACTTCAAAGCTAAGAAGAAGGAACTGGAAGAAATTGTTC
AACCAATTATCAGCAAACTCTATGGAAGTGCAGGCCCTCCCCCAACTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTG
TAGACACTGATCTGCTAGTGCTGTAATATTGTAAATACTGGACTCAGGAACTTTTGTTAGGAAAAAATTGAAAGAACTTA
AGTCTCGAATGTAATTGGAATCTTCACCTCAGAGTGGAGTTGAAACTGCTATAGCCTAAGCGGCTGTTTACTGCTTTTCA
TTAGCAGTTGCTCACATGTCTTTGGGTGGGGGGGAGAAGAAGAATTGGCCATCTTAAAAAGCGGGTAAAAAACCTGGGTT
AGGGTGTGTGTTCACCTTCAAAATGTTCTATTTAACAACTGGGTCATGTGCATCTGGTGTAGGAAGTTTTTTCTACCATA
AGTGACACCAATAAATGTTTGTTATTTACACTGGTCTAATGTTTGTGAGAAGCTTCTAATTAGATCAATTACTTATTTTA
GGAAATTTAAGACTAGATACTCGTGTGTGGGGTGAGGGGAGGGAGTATTTGGTATGTTGGGATAAGGAAACACTTCTATT
TAATGCTTCCAGGGATTTTTTTTTTTTTTTTTAACCCTCCTGGGCCCAAGTGATCCTTCCACCTCAGTCTCCCAGCTAAT
TGAGACCACAGGCTTGTTACCACCATGCTCGGCTTTTGCATTAATCTAAGAAAAGGGGAGAGAAGTTAATCCACATCTTT
ACTCAGGCAAGGGGCATTTCACAGTGCCCAAGAGTGGGGTTTTCTTGAACATACTTGGTTTCCTATTTCCCCTTATCTTT
CTAAAACTGCCTTTCTGGTGGCTTTTTTTAAAATTATTACTAATGATGCTTTTATAGCTGCTTGGATTCTCTGAGAAATG
ATGGGGAGTGAGTGATCACTGGTATTAACTTTATACACTTGGATTTCATTTGTAACTTTAGGATGTAAAGGTATATTGTG
AACCCTAGCTGTGTCAGAATCTCCATCCCTGAAATTTCTCATTAGTGGTACTGGGGTGGGATCTTGGATGGTGACATTGA
AACTACACTAAATCCCCTCACTATGAATGGGTTGTTAAAGGCAATGGTTTGTGTCAAAACTGGTTTAGGATTACTTAGAT
TGTGTTCCTGAAGAAAAGAGTCCAGGTAAATGGTATGATCAATAAAGGACAGGCTGGTGCTAACATAAAATCCAATATTG
TAATCCTAGCACTTTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAAGAGATAGAGACCATCTTTGCCAACATGGTGAAA
CTCCATCTCTACTGAAAATACAAAAATTAGCTGGGCGTGGTAGTGCAAGCTGAAGGCTGAGGCAGGAGAATCACTCGAAC
CCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCACACCACTGTACTCCAGCCCGGCACTCCAGCCTGGCGACAAGAGTGAG
ACTCCACCTCAAAAAAAAAAAAAAGAATCCAATACTGCCCAAGGATAGGTATTTTATAGATGGGCAACTGGCTGAAAGGT
TAATTCTCTAGGGCTAGTAGAACTGGATCCCAACACCAAACTCTTAATTAGACCTAGGCCTCAGCTGCACTGCCCGAAAA
GCATTTGGGCAGACCCTGAGCAGAATACTGGTCTCAGGCCAAGCCCAATACAGCCATTAAAGATGACCTACAGTGCTGTG
TACCCTGGGGCAATAGGGTTAAATGGTAGTTAGCAACTAGGGCTAGTCTTCCCTTACCTCAAAGGCTCTCACTACCGTGG
ACCACCTAGTCTGTAACTCTTTCTGAGGAGCTGTTACTGAATATTAAAAAGATAGACTTCAACTATG
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Primary source |
Uniprot : P11021
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Name |
78 kDa glucose-regulated protein
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Alternative name(s) |
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 Heat shock 70 kDa protein 5 Immunoglobulin heavy chain-binding protein
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Synonym(s) |
BiP GRP-78
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Organism |
Homo sapiens
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Length |
654 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Disease
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Autoantigen in rheumatoid arthritis [MIM:180300].
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Function
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Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
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Similarity
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Belongs to the heat shock protein 70 family.
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Subcellular location
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Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Subunit
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Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A. May form a complex with ERLEC1, OS9, SEL1L and SYVN1.
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Biological process
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anti-apoptosis [GO:0006916]
ER-associated protein catabolic process [GO:0030433]
cellular response to glucose starvation [GO:0042149]
negative regulation of caspase activity [GO:0043154]
regulation of protein folding in endoplasmic reticulum [GO:0060904]
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Cellular component
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nucleus [GO:0005634]
endoplasmic reticulum lumen [GO:0005788]
ER-Golgi intermediate compartment [GO:0005793]
cell surface [GO:0009986]
integral to endoplasmic reticulum membrane [GO:0030176]
melanosome [GO:0042470]
perinuclear region of cytoplasm [GO:0048471]
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Molecular function
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calcium ion binding [GO:0005509]
ATP binding [GO:0005524]
protein binding, bridging [GO:0030674]
caspase inhibitor activity [GO:0043027]
unfolded protein binding [GO:0051082]
chaperone binding [GO:0051087]
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With
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Uniprot accession
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IntAct
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NDRG1
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Q92597
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EBI-354921,EBI-716486
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RAF1
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P04049
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EBI-354921,EBI-365996
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PTEN
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P60484
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EBI-354921,EBI-696162
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CASP8
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Q14790
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EBI-354921,EBI-78060
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TMEM62
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Q0P6H9
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EBI-354921,EBI-719020
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PAWR
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Q96IZ0
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EBI-354921,EBI-595869
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CAV1
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Q03135
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EBI-354921,EBI-603614
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E2AK3
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Q9NZJ5
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EBI-354921,EBI-766076
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FCHSD2
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O94868
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EBI-354921,EBI-1215612
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Pawr (xeno)
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Q62627
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EBI-354921,EBI-1187240
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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Molecule processing |
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Signal
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1 - 18
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18
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P11021-SIGNAL-1
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Region |
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Motif
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651 - 654
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4
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Prevents secretion from ER
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P11021-MOTIF-651
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Natural variations |
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Natural variant site
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543 - 543
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1
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N -> H (in dbSNP:rs35356639)
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VAR_025815
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Amino acid modifications |
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Modified residue
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166 - 166
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1
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Phosphothreonine (By similarity)
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P11021-MOD_RES-166
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Modified residue
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268 - 268
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1
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N6-acetyllysine
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P11021-MOD_RES-268
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Modified residue
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466 - 466
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1
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Phosphotyrosine
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P11021-MOD_RES-466
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Modified residue
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571 - 571
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1
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Phosphoserine (By similarity)
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P11021-MOD_RES-571
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1 |
MKLSLVAAML |
LLLSAARAEE |
EDKKEDVGTV |
VGIDLGTTYS |
CVGVFKNGRV |
EIIANDQGNR |
ITPSYVAFTP |
EGERLIGDAA |
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81 |
KNQLTSNPEN |
TVFDAKRLIG |
RTWNDPSVQQ |
DIKFLPFKVV |
EKKTKPYIQV |
DIGGGQTKTF |
APEEISAMVL |
TKMKETAEAY |
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161 |
LGKKVTHAVV |
TVPAYFNDAQ |
RQATKDAGTI |
AGLNVMRIIN |
EPTAAAIAYG |
LDKREGEKNI |
LVFDLGGGTF |
DVSLLTIDNG |
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241 |
VFEVVATNGD |
THLGGEDFDQ |
RVMEHFIKLY |
KKKTGKDVRK |
DNRAVQKLRR |
EVEKAKRALS |
SQHQARIEIE |
SFYEGEDFSE |
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321 |
TLTRAKFEEL |
NMDLFRSTMK |
PVQKVLEDSD |
LKKSDIDEIV |
LVGGSTRIPK |
IQQLVKEFFN |
GKEPSRGINP |
DEAVAYGAAV |
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401 |
QAGVLSGDQD |
TGDLVLLDVC |
PLTLGIETVG |
GVMTKLIPRN |
TVVPTKKSQI |
FSTASDNQPT |
VTIKVYEGER |
PLTKDNHLLG |
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481 |
TFDLTGIPPA |
PRGVPQIEVT |
FEIDVNGILR |
VTAEDKGTGN |
KNKITITNDQ |
NRLTPEEIER |
MVNDAEKFAE |
EDKKLKERID |
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561 |
TRNELESYAY |
SLKNQIGDKE |
KLGGKLSSED |
KETMEKAVEE |
KIEWLESHQD |
ADIEDFKAKK |
KELEEIVQPI |
ISKLYGSAGP |
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641 |
PPTGEEDTAE |
KDEL |
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>sp|P11021|GRP78_human 78 kDa glucose-regulated protein
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAA
KNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY
LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSE
TLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAV
QAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERID
TRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGP
PPTGEEDTAEKDEL
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