(HSP90AB1) heat shock protein 90kDa alpha (cytosolic), class B member 1 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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3938
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Official symbol
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HSP90AB1
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Official name
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heat shock protein 90kDa alpha (cytosolic), class B member 1
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 6 (NC_000006.11) : 44214848...44221613 (+)
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Map
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6p12
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Length
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6766 nt
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NM_007355.2
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HSP90AB1, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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P08238
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Heat shock protein HSP 90-beta
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Homo sapiens
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724 aa
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Synonyms |
HSP90B; HSP90-BETA; FLJ26984; D6S182; HSPCB; HSPC2
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Alternative name(s) |
heat shock protein beta; heat shock 90kDa protein 1, beta; heat shock 90kD protein 1, beta
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Summary |
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM].
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Related Articles in PubMed
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Go to ensembl
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1 |
ACTCCGGCGC |
AGTGTTGGGA |
CTGTCTGGGT |
ATCGGAAAGC |
AAGCCTACGT |
TGCTCACTAT |
TACGTATAAT |
CCTTTTCTTT |
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81 |
TCAAGGTAAG |
GCTGAGATCT |
CCGCTAGGCT |
TCTTTCCCTT |
TAGTGCTGTA |
TTCGTGTTGT |
TTTTGTTTTT |
TTCTGTCCTT |
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161 |
TAGGGAGCCT |
TAGTCTAGAT |
GTCGGGGTGG |
CTTGTGGATA |
ACGCTCTGGA |
TTTTTATAGG |
GTGAGGGTAG |
TGGTGGGTGA |
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241 |
GGTTTTTTGA |
GTCCTCCTCG |
GTTTTCTCTA |
GTGTGTTTGG |
GGGGTGGGGC |
TTTCTCTCGG |
CGCCTGCTGG |
CCGTAGCGAG |
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321 |
GTGGGCTGTG |
GGGTTGGGGC |
AGTGGGCGGC |
TGGCAGCTGC |
ACGTGGTGGC |
CGCGCGGCCC |
GGGACGCTGC |
CATTTTTGCC |
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401 |
CCTCCACTTC |
CGGACGCGGC |
TACGGGGCGT |
CGGAGGGGGA |
CCGCAGGGTG |
GCGGGGGTGC |
CCGCTCGGGT |
GACTCAGCAC |
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481 |
GGCCTTGTGG |
GACTGGCTTT |
GTCACCTCTC |
TTATCGGACG |
CGTTGTTAAA |
GCCTTCTTGG |
GTGCTTTGTT |
TCTGTGAGGG |
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561 |
AGGGTTGACG |
GTGTGGGAAG |
AGAGCTTTCG |
GTCTCCAGCA |
CCCGATACTC |
CCTCCTTCCA |
GATCTTTCTT |
GCAGTCCCGG |
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641 |
TGGAGGAGGG |
GCGGGGAGGG |
GAGCAGGTTC |
TGGAAGATTC |
ATGGGCTCCT |
TCCTCCGCCC |
TTCCTCGAGA |
GCTGAGATTG |
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721 |
TTCTGGAAGC |
TTCTGGATTC |
TGGCGCCCCG |
CCCCAGTGCC |
CGGATGCTGG |
GGCGAGGGAG |
GGTGCACTGC |
GGCGCCCCCT |
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801 |
CCTCGCGTGG |
TCCTGGCCGA |
CGCATGTCCG |
GCAGTGACGA |
GTGTCGGCCT |
GGTGGCTACG |
GCCACCATCT |
TTCTTGGGTT |
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881 |
TGGTCCTGTT |
CTGTAATTTT |
GTGCTGTGAA |
AGGGTCGTGG |
TGGAGCTTTT |
GGCTTAAGAA |
TTCTTTGTCC |
GGATTTAATT |
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961 |
GCTCCTCCGG |
TGGGTATCGT |
ATGGATCCCA |
GGTTATTCCT |
CCCTGCCCTA |
TGGGGCAGGA |
GTGTCCCGCC |
CTTGGACTGG |
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1041 |
TCTTAGGAAC |
TGACACCTCA |
GGGGGAGCAG |
TTTAAAGTTA |
GTGCCATTTT |
TATCTTAAAC |
TAGTCACTTT |
GATCTCCCCC |
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1121 |
AAATAAAGAA |
CTGTAGGTAG |
TGATTTTCAC |
ATTTAAATTT |
GTGTAAGGAT |
TACTTGGGAT |
CTCTAGATAC |
CTGGGTTGGA |
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1201 |
CCAACATTAT |
GATTTTTCTG |
CCATACTACC |
AGATGATGCT |
GAGGCTGCTG |
GTCACCATTC |
TTTAAGTAGG |
TGGGTTCTGT |
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1281 |
GACATTTGGT |
TGAAGAATAT |
TTAGCTTATT |
TTCTTTTTCC |
TTCTGAATTT |
TCAGGCCTCC |
CACTTAGTGT |
GTAGTCTGAG |
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1361 |
ATCTTTAAGA |
GAATGCATTT |
TTAGTCTTGG |
GAAGGGATAG |
TACTCCGGTT |
AAACCAGTCT |
GAACTCACTG |
TCTAAGGTCC |
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1441 |
TAACAAATGA |
TATGACCTTT |
AGGATTTTTA |
AACATGGGGC |
CTTAGTGTTC |
TTTTGTAATT |
AATGAGATTT |
TTATTTTAGA |
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1521 |
TGCCTGAGGA |
AGTGCACCAT |
GGAGAGGAGG |
AGGTGGAGAC |
TTTTGCCTTT |
CAGGCAGAAA |
TTGCCCAACT |
CATGTCCCTC |
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1601 |
ATCATCAATA |
CCTTCTATTC |
CAACAAGGAG |
ATTTTCCTTC |
GGGAGTTGAT |
CTCTAATGCT |
TCTGATGTAG |
GTGCTCTGGT |
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1681 |
TTCCACATTT |
GGCATGGTTT |
TTTTTTTTGA |
TACTCTAGAA |
GGAGGGGAAA |
GGAGTGGTTT |
GGCCTTTGTT |
GGGGACTACT |
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1761 |
ATTGAAGGGG |
GTAAACTTGC |
AGCTATTCCA |
AAAAGATGGG |
TTTTACTCTG |
GCCATCTTGA |
ACTTGGAAGG |
GACTATGTCC |
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1841 |
AGAATAAGTG |
GGCTCATGGA |
ACTAACTGGT |
TCTAAAGCCT |
CAAGATAGGG |
GGCAATCAGA |
TTTGAGGCTG |
AGAGAGGTAA |
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1921 |
ACCAAGATTT |
TCTTTGAAGA |
TACGGGCTTT |
AAGAAAGCAA |
AAGTGGCTGA |
GCGTGTTGGC |
TCACACCTGT |
AATGCCAAGG |
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2001 |
CAGGAGGATC |
ACTTGAGCCT |
AGGATTTCGA |
GGGCAGCCTG |
GGCAACCGCG |
AGACCTTGTC |
TCTGCAAAAA |
ATTAAATATT |
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2081 |
AGTTGGGCAC |
GGTGGCATGT |
GCCTGTAGTC |
CCAGCTACTT |
GGGAAGCTGG |
GGTTGGGAGG |
ATGGCTCGAA |
CCTGGGAGGT |
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2161 |
CAAGGCTGCA |
GTGAGCTGTC |
ATCCTTGCCA |
CTGCACTGTA |
GCTTGGGCAA |
CAGAGCAAGA |
GTCTGTCTTG |
GAAAGAGCAA |
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2241 |
AAGTAAGTTG |
CTGTTTGTAT |
TTCCAGGCCT |
TGGACAAGAT |
TCGCTATGAG |
AGCCTGACAG |
ACCCTTCGAA |
GTTGGACAGT |
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2321 |
GGTAAAGAGC |
TGAAAATTGA |
CATCATCCCC |
AACCCTCAGG |
AACGTACCCT |
GACTTTGGTA |
GACACAGGCA |
TTGGCATGAC |
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2401 |
CAAAGCTGAT |
CTCATAAATA |
ATTTGGGAAC |
CATTGCCAAG |
TCTGGTACTA |
AAGCATTCAT |
GGAGGCTCTT |
CAGGTATTGC |
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2481 |
AGTTCTGTAG |
GCATTCATAC |
TTATCTGTGT |
TCTTTGGTTT |
TTTGCTTCTT |
TAAAACTTGT |
GATTGACTTT |
AAACTTGTTG |
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2561 |
GCAGGCTGGT |
GCAGACATCT |
CCATGATTGG |
GCAGTTTGGT |
GTTGGCTTTT |
ATTCTGCCTA |
CTTGGTGGCA |
GAGAAAGTGG |
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2641 |
TTGTGATCAC |
AAAGCACAAC |
GATGATGAAC |
AGTATGCTTG |
GGAGTCTTCT |
GCTGGAGGTT |
CCTTCACTGT |
GCGTGCTGAC |
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2721 |
CATGGTAAGT |
TAGCTTTTCT |
GTTACAAGGT |
AGTTGGGTTA |
GGATTTTCTG |
GGCTCACACC |
AGTAGCAGAA |
ATTTTGGGCA |
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2801 |
TCCTGTCTGT |
AAAGCAGTTC |
TTCACAGCAG |
TTCTGCTGAT |
ACTTACTAAT |
TGCTGGTCTC |
AACTGCATAT |
ACTTTTTACC |
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2881 |
CTGTTACACG |
CTTGTAATTG |
ACTCTTCTAG |
GTGAGCCCAT |
TGGCAGGGGT |
ACCAAAGTGA |
TCCTCCATCT |
TAAAGAAGAT |
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2961 |
CAGACAGAGT |
ACCTAGAAGA |
GAGGCGGGTC |
AAAGAAGTAG |
TGAAGAAGCA |
TTCTCAGTTC |
ATAGGCTATC |
CCATCACCCT |
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3041 |
TTATGTGAGT |
ATGGACTTTT |
AAATCTTTTA |
CACTTAACGT |
GCAGGATGTT |
TCCTGTTCTG |
GAGAATCTCA |
TTGTCCCTGG |
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3121 |
CTTTTGCTTT |
CCCTGGTAGT |
GTTTTGTACT |
CCAAGGCTAA |
CTTCTGTTTT |
TGTTACTTAG |
TTGGAGAAGG |
AACGAGAGAA |
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3201 |
GGAAATTAGT |
GATGATGAGG |
CAGAGGAAGA |
GAAAGGTGAG |
AAAGAAGAGG |
AAGATAAAGA |
TGATGAAGAA |
AAACCCAAGA |
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3281 |
TCGAAGATGT |
GGGTTCAGAT |
GAGGAGGATG |
ACAGCGGTAA |
GGATAAGAAG |
AAGAAAACTA |
AGAAGATCAA |
AGAGAAATAC |
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3361 |
ATTGATCAGG |
AAGAACTAAA |
CAAGACCAAG |
CCTATTTGGA |
CCAGAAACCC |
TGATGACATC |
ACCCAAGAGG |
AGTATGGAGA |
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3441 |
ATTCTACAAG |
AGCCTCACTA |
ATGACTGGGA |
AGACCACTTG |
GCAGTCAAGG |
TGTGAGAAGC |
CTTTGCATGT |
TGGCTCAACA |
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3521 |
TGCACATATG |
GAGAGGAATG |
AGTTAGGTGG |
AAGAGTGTTG |
GGTAATAGAC |
ACACGGAACT |
TGTCCAACTG |
ATAACAGAAA |
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3601 |
TGTGATAGCC |
ATGTGATTTC |
ACTTACTGAT |
TACCCTGTCA |
TAGTGAAGTG |
CCATCATTTC |
TAATGACCTC |
ACTTTCTCTT |
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3681 |
CTTATGGAAA |
TCTGGGTAAT |
GTCTATTGGC |
AGCCTTACAC |
ATCCAGGGTT |
CTGATCAGAG |
GGGACTGTTT |
TCTACATACA |
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3761 |
GCTAGTACCC |
ATCTAGATCG |
TGGAGGGCAT |
TAAGGCTCAG |
TTTTCTCAGG |
AGCTGCTTGT |
TGTGTGTGCT |
CTATCCCTTA |
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3841 |
GGCTTAGGGA |
GGATCATTGT |
TCCACTTTTA |
GATAATTTGG |
TGTTGGGGCT |
AAAAGGTCCT |
CTTTTGAAAT |
GTACCACTTA |
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3921 |
TTTTTGGTTT |
CTTTCAGCAC |
TTTTCTGTAG |
AAGGTCAGTT |
GGAATTCAGG |
GCATTGCTAT |
TTATTCCTCG |
TCGGGCTCCC |
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4001 |
TTTGACCTTT |
TTGAGAACAA |
GAAGAAAAAG |
AACAACATCA |
AACTCTATGT |
CCGCCGTGTG |
TTCATCATGG |
ACAGCTGTGA |
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4081 |
TGAGTTGATA |
CCAGAGTATC |
TCAGTGAGTA |
TCTCCTTGGC |
CTAATTTAGT |
TGGGTGAAGT |
CTTGGGAGGT |
TTTAGGCATT |
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4161 |
CTGCTAGGAT |
ATTCTAAGGT |
AACAGTTTTC |
TGCAATACAT |
AGTAGGTGTA |
AGGGTTCAGG |
AGGCTATTAG |
AGCCTTCTGT |
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4241 |
TTGAATCTGG |
GGACCAGGTC |
TGGTCTAGCT |
GTTTTTTACT |
GAGCTTTCTC |
ACCCTGGTTG |
ATGGCAGATT |
TTATCCGTGG |
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4321 |
TGTGGTTGAC |
TCTGAGGATC |
TGCCCCTGAA |
CATCTCCCGA |
GAAATGCTCC |
AGCAGAGCAA |
AATCTTGAAA |
GTCATTCGCA |
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4401 |
AAAACATTGT |
TAAGAAGTGC |
CTTGAGCTCT |
TCTCTGAGCT |
GGCAGAAGAC |
AAGGAGAATT |
ACAAGAAATT |
CTATGAGGCA |
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4481 |
TTCTCTAAAA |
ATCTCAAGGT |
AAAAAGGCAA |
ATAATGCTTA |
TTCCCTTTAC |
CACTTTCTTA |
GTAATAACAA |
TAAATTATTC |
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4561 |
CATTCACATT |
GAAAGTGAAG |
TTATTGTAGT |
TAAGCTGGAT |
TGTTTTTCCT |
CTTCCCACCC |
TTCAAGCTTG |
GAATCCACGA |
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4641 |
AGACTCCACT |
AACCGCCGCC |
GCCTGTCTGA |
GCTGCTGCGC |
TATCATACCT |
CCCAGTCTGG |
AGATGAGATG |
ACATCTCTGT |
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4721 |
CAGAGTATGT |
TTCTCGCATG |
AAGGAGACAC |
AGAAGTCCAT |
CTATTACATC |
ACTGGTGCGT |
TGACTCTGAT |
TGAAGCCTTT |
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4801 |
TTGGAGGAGT |
GGGGAGCACA |
ATTAGGGCTT |
CCTGGGAACT |
GGCAGTATGA |
GGCATTTTAG |
TCACTGAGTT |
CATTTAATTA |
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4881 |
CCCTACAGGT |
GAGAGCAAAG |
AGCAGGTGGC |
CAACTCAGCT |
TTTGTGGAGC |
GAGTGCGGAA |
ACGGGGCTTC |
GAGGTGGTAT |
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4961 |
ATATGACCGA |
GCCCATTGAC |
GAGTACTGTG |
TGCAGCAGCT |
CAAGGAATTT |
GATGGGAAGA |
GCCTGGTCTC |
AGTTACCAAG |
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5041 |
GAGGGTCTGG |
AGCTGCCTGA |
GGATGAGGAG |
GAGAAGAAGA |
AGATGGAAGA |
GAGCAAGGCA |
AAGTTTGAGA |
ACCTCTGCAA |
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5121 |
GCTCATGAAA |
GAAATCTTAG |
ATAAGAAGGT |
TGAGAAGGTA |
AGCCATTCTG |
GGGCTAGGAT |
ATATTTTGTA |
ACATCTTCGA |
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5201 |
GGTGGGCTCC |
CTCACAAGCA |
TGTTTCTATA |
CAATTAGTGG |
TTTGAGGCAG |
CCTATTTACT |
GTTTCATGCC |
TTCTTGCCTC |
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5281 |
TTGTTCTCTT |
CTCTAGTCAG |
GTTTAAGGCT |
ATTTTAATAA |
AATTTGGCAC |
AGATTAGGCA |
TTGCTTCAGT |
TAACTTCTGA |
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5361 |
GAGTAGATAA |
AATACCATCA |
TTTTCTTTTT |
TTTTTCTTTT |
TTTGAGATGG |
GGTCTCGCTC |
TGTCACCCAG |
GCTGGAGTGC |
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5441 |
AGTGGCACGA |
TCTCTGCTCA |
TTGCAAGCTC |
CGCCTCCTGG |
GTTCACGCCA |
TTCTCCTGCC |
TTAGCCTCCT |
GAGTAGCTGC |
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5521 |
CACTACAGGC |
GCCCGCCACC |
ACACCCCGGC |
TAATTTTTTG |
TATTTTTAGT |
AGAGATGGGG |
TTTCATCGCG |
TTAGCCAGGA |
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5601 |
TGGTCTCCAT |
CTCCTGACCT |
TGTGATTCGC |
CCACCTCGGC |
CTCCCAAAGT |
GCTGGGATTA |
ACAGGCGCAA |
GCCACCATGC |
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5681 |
CTGGCCGATT |
TTTTTTTTTT |
TTGGACTGGA |
TCTCGCTCAC |
TGCAAACTCA |
AGTCTCCTGA |
GTGGCTGGGA |
TTACAGATGT |
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5761 |
GTGCTACCAC |
ACCCGGTTAA |
TTTTTTGTAG |
ACAGGGTTTT |
GCCATGTTGG |
CCAGCATGGT |
CTCAAACTCA |
AGTGGTCTGT |
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5841 |
CCACCTCCTC |
CCCCTGCTGG |
AATTAGGCTT |
GACAATGCCT |
GTTTTCTCTT |
TCAAAGTGGT |
AATGTCAATC |
TAAGGCTTTT |
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5921 |
GTGATCGTCC |
ACAGGTGACA |
ATCTCCAATA |
GACTTGTGTC |
TTCACCTTGC |
TGCATTGTGA |
CCAGCACCTA |
CGGCTGGACA |
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6001 |
GCCAATATGG |
AGCGGATCAT |
GAAAGCCCAG |
GCACTTCGGG |
ACAACTCCAC |
CATGGGCTAT |
ATGATGGCCA |
AAAAGCACCT |
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6081 |
GGAGATCAAC |
CCTGACCACC |
CCATTGTGGA |
GACGCTGCGG |
CAGAAGGCTG |
AGGCCGACAA |
GAATGATAAG |
GCAGTTAAGG |
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6161 |
ACCTGGTGGT |
GCTGCTGTTT |
GAAACCGCCC |
TGCTATCTTC |
TGGCTTTTCC |
CTTGAGGATC |
CCCAGACCCA |
CTCCAACCGC |
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6241 |
ATCTATCGCA |
TGATCAAGCT |
AGGTCTAGGT |
AAGTAGCTTT |
GGTACTTGGT |
GTGGCAAGGA |
GTTTGTGCAA |
CTCGTCTCCT |
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6321 |
CTATGGATTT |
GACTTAATGC |
TATTTGGTCA |
AGTCTCACAT |
GGCTTAATTT |
TACTTCAGGT |
ATTGATGAAG |
ATGAAGTGGC |
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6401 |
AGCAGAGGAA |
CCCAATGCTG |
CAGTTCCTGA |
TGAGATCCCC |
CCTCTCGAGG |
GCGATGAGGA |
TGCGTCTCGC |
ATGGAAGAAG |
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6481 |
TCGATTAGGT |
TAGGAGTTCA |
TAGTTGGAAA |
ACTTGTGCCC |
TTGTATAGTG |
TCCCCATGGG |
CTCCCACTGC |
AGCCTCGAGT |
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6561 |
GCCCCTGTCC |
CACCTGGCTC |
CCCCTGCTGG |
TGTCTAGTGT |
TTTTTTCCCT |
CTCCTGTCCT |
TGTGTTGAAG |
GCAGTAAACT |
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6641 |
AAGGGTGTCA |
AGCCCCATTC |
CCTCTCTACT |
CTTGACAGCA |
GGATTGGATG |
TTGTGTATTG |
TGGTTTATTT |
TATTTTCTTC |
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6721 |
ATTTTGTTCT |
GAAATTAAAG |
TATGCAAAAT |
AAAGAATATG |
CCGTTT |
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>ref|Gene_ID:3326|HSP90AB1|NC_000006.11:44214848...44221613 (+)
ACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTATAATCCTTTTCTTT
TCAAGGTAAGGCTGAGATCTCCGCTAGGCTTCTTTCCCTTTAGTGCTGTATTCGTGTTGTTTTTGTTTTTTTCTGTCCTT
TAGGGAGCCTTAGTCTAGATGTCGGGGTGGCTTGTGGATAACGCTCTGGATTTTTATAGGGTGAGGGTAGTGGTGGGTGA
GGTTTTTTGAGTCCTCCTCGGTTTTCTCTAGTGTGTTTGGGGGGTGGGGCTTTCTCTCGGCGCCTGCTGGCCGTAGCGAG
GTGGGCTGTGGGGTTGGGGCAGTGGGCGGCTGGCAGCTGCACGTGGTGGCCGCGCGGCCCGGGACGCTGCCATTTTTGCC
CCTCCACTTCCGGACGCGGCTACGGGGCGTCGGAGGGGGACCGCAGGGTGGCGGGGGTGCCCGCTCGGGTGACTCAGCAC
GGCCTTGTGGGACTGGCTTTGTCACCTCTCTTATCGGACGCGTTGTTAAAGCCTTCTTGGGTGCTTTGTTTCTGTGAGGG
AGGGTTGACGGTGTGGGAAGAGAGCTTTCGGTCTCCAGCACCCGATACTCCCTCCTTCCAGATCTTTCTTGCAGTCCCGG
TGGAGGAGGGGCGGGGAGGGGAGCAGGTTCTGGAAGATTCATGGGCTCCTTCCTCCGCCCTTCCTCGAGAGCTGAGATTG
TTCTGGAAGCTTCTGGATTCTGGCGCCCCGCCCCAGTGCCCGGATGCTGGGGCGAGGGAGGGTGCACTGCGGCGCCCCCT
CCTCGCGTGGTCCTGGCCGACGCATGTCCGGCAGTGACGAGTGTCGGCCTGGTGGCTACGGCCACCATCTTTCTTGGGTT
TGGTCCTGTTCTGTAATTTTGTGCTGTGAAAGGGTCGTGGTGGAGCTTTTGGCTTAAGAATTCTTTGTCCGGATTTAATT
GCTCCTCCGGTGGGTATCGTATGGATCCCAGGTTATTCCTCCCTGCCCTATGGGGCAGGAGTGTCCCGCCCTTGGACTGG
TCTTAGGAACTGACACCTCAGGGGGAGCAGTTTAAAGTTAGTGCCATTTTTATCTTAAACTAGTCACTTTGATCTCCCCC
AAATAAAGAACTGTAGGTAGTGATTTTCACATTTAAATTTGTGTAAGGATTACTTGGGATCTCTAGATACCTGGGTTGGA
CCAACATTATGATTTTTCTGCCATACTACCAGATGATGCTGAGGCTGCTGGTCACCATTCTTTAAGTAGGTGGGTTCTGT
GACATTTGGTTGAAGAATATTTAGCTTATTTTCTTTTTCCTTCTGAATTTTCAGGCCTCCCACTTAGTGTGTAGTCTGAG
ATCTTTAAGAGAATGCATTTTTAGTCTTGGGAAGGGATAGTACTCCGGTTAAACCAGTCTGAACTCACTGTCTAAGGTCC
TAACAAATGATATGACCTTTAGGATTTTTAAACATGGGGCCTTAGTGTTCTTTTGTAATTAATGAGATTTTTATTTTAGA
TGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACTCATGTCCCTC
ATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGTAGGTGCTCTGGT
TTCCACATTTGGCATGGTTTTTTTTTTTGATACTCTAGAAGGAGGGGAAAGGAGTGGTTTGGCCTTTGTTGGGGACTACT
ATTGAAGGGGGTAAACTTGCAGCTATTCCAAAAAGATGGGTTTTACTCTGGCCATCTTGAACTTGGAAGGGACTATGTCC
AGAATAAGTGGGCTCATGGAACTAACTGGTTCTAAAGCCTCAAGATAGGGGGCAATCAGATTTGAGGCTGAGAGAGGTAA
ACCAAGATTTTCTTTGAAGATACGGGCTTTAAGAAAGCAAAAGTGGCTGAGCGTGTTGGCTCACACCTGTAATGCCAAGG
CAGGAGGATCACTTGAGCCTAGGATTTCGAGGGCAGCCTGGGCAACCGCGAGACCTTGTCTCTGCAAAAAATTAAATATT
AGTTGGGCACGGTGGCATGTGCCTGTAGTCCCAGCTACTTGGGAAGCTGGGGTTGGGAGGATGGCTCGAACCTGGGAGGT
CAAGGCTGCAGTGAGCTGTCATCCTTGCCACTGCACTGTAGCTTGGGCAACAGAGCAAGAGTCTGTCTTGGAAAGAGCAA
AAGTAAGTTGCTGTTTGTATTTCCAGGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGT
GGTAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGAC
CAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCATGGAGGCTCTTCAGGTATTGC
AGTTCTGTAGGCATTCATACTTATCTGTGTTCTTTGGTTTTTTGCTTCTTTAAAACTTGTGATTGACTTTAAACTTGTTG
GCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGG
TTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGAC
CATGGTAAGTTAGCTTTTCTGTTACAAGGTAGTTGGGTTAGGATTTTCTGGGCTCACACCAGTAGCAGAAATTTTGGGCA
TCCTGTCTGTAAAGCAGTTCTTCACAGCAGTTCTGCTGATACTTACTAATTGCTGGTCTCAACTGCATATACTTTTTACC
CTGTTACACGCTTGTAATTGACTCTTCTAGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGAT
CAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCT
TTATGTGAGTATGGACTTTTAAATCTTTTACACTTAACGTGCAGGATGTTTCCTGTTCTGGAGAATCTCATTGTCCCTGG
CTTTTGCTTTCCCTGGTAGTGTTTTGTACTCCAAGGCTAACTTCTGTTTTTGTTACTTAGTTGGAGAAGGAACGAGAGAA
GGAAATTAGTGATGATGAGGCAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGA
TCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATAC
ATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGA
ATTCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGGTGTGAGAAGCCTTTGCATGTTGGCTCAACA
TGCACATATGGAGAGGAATGAGTTAGGTGGAAGAGTGTTGGGTAATAGACACACGGAACTTGTCCAACTGATAACAGAAA
TGTGATAGCCATGTGATTTCACTTACTGATTACCCTGTCATAGTGAAGTGCCATCATTTCTAATGACCTCACTTTCTCTT
CTTATGGAAATCTGGGTAATGTCTATTGGCAGCCTTACACATCCAGGGTTCTGATCAGAGGGGACTGTTTTCTACATACA
GCTAGTACCCATCTAGATCGTGGAGGGCATTAAGGCTCAGTTTTCTCAGGAGCTGCTTGTTGTGTGTGCTCTATCCCTTA
GGCTTAGGGAGGATCATTGTTCCACTTTTAGATAATTTGGTGTTGGGGCTAAAAGGTCCTCTTTTGAAATGTACCACTTA
TTTTTGGTTTCTTTCAGCACTTTTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCC
TTTGACCTTTTTGAGAACAAGAAGAAAAAGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGA
TGAGTTGATACCAGAGTATCTCAGTGAGTATCTCCTTGGCCTAATTTAGTTGGGTGAAGTCTTGGGAGGTTTTAGGCATT
CTGCTAGGATATTCTAAGGTAACAGTTTTCTGCAATACATAGTAGGTGTAAGGGTTCAGGAGGCTATTAGAGCCTTCTGT
TTGAATCTGGGGACCAGGTCTGGTCTAGCTGTTTTTTACTGAGCTTTCTCACCCTGGTTGATGGCAGATTTTATCCGTGG
TGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAAAATCTTGAAAGTCATTCGCA
AAAACATTGTTAAGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAAATTCTATGAGGCA
TTCTCTAAAAATCTCAAGGTAAAAAGGCAAATAATGCTTATTCCCTTTACCACTTTCTTAGTAATAACAATAAATTATTC
CATTCACATTGAAAGTGAAGTTATTGTAGTTAAGCTGGATTGTTTTTCCTCTTCCCACCCTTCAAGCTTGGAATCCACGA
AGACTCCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCTGT
CAGAGTATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGCGTTGACTCTGATTGAAGCCTTT
TTGGAGGAGTGGGGAGCACAATTAGGGCTTCCTGGGAACTGGCAGTATGAGGCATTTTAGTCACTGAGTTCATTTAATTA
CCCTACAGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTAT
ATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGATGGGAAGAGCCTGGTCTCAGTTACCAAG
GAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAAGTTTGAGAACCTCTGCAA
GCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGGTAAGCCATTCTGGGGCTAGGATATATTTTGTAACATCTTCGA
GGTGGGCTCCCTCACAAGCATGTTTCTATACAATTAGTGGTTTGAGGCAGCCTATTTACTGTTTCATGCCTTCTTGCCTC
TTGTTCTCTTCTCTAGTCAGGTTTAAGGCTATTTTAATAAAATTTGGCACAGATTAGGCATTGCTTCAGTTAACTTCTGA
GAGTAGATAAAATACCATCATTTTCTTTTTTTTTTCTTTTTTTGAGATGGGGTCTCGCTCTGTCACCCAGGCTGGAGTGC
AGTGGCACGATCTCTGCTCATTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTGCCTTAGCCTCCTGAGTAGCTGC
CACTACAGGCGCCCGCCACCACACCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCATCGCGTTAGCCAGGA
TGGTCTCCATCTCCTGACCTTGTGATTCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTAACAGGCGCAAGCCACCATGC
CTGGCCGATTTTTTTTTTTTTTGGACTGGATCTCGCTCACTGCAAACTCAAGTCTCCTGAGTGGCTGGGATTACAGATGT
GTGCTACCACACCCGGTTAATTTTTTGTAGACAGGGTTTTGCCATGTTGGCCAGCATGGTCTCAAACTCAAGTGGTCTGT
CCACCTCCTCCCCCTGCTGGAATTAGGCTTGACAATGCCTGTTTTCTCTTTCAAAGTGGTAATGTCAATCTAAGGCTTTT
GTGATCGTCCACAGGTGACAATCTCCAATAGACTTGTGTCTTCACCTTGCTGCATTGTGACCAGCACCTACGGCTGGACA
GCCAATATGGAGCGGATCATGAAAGCCCAGGCACTTCGGGACAACTCCACCATGGGCTATATGATGGCCAAAAAGCACCT
GGAGATCAACCCTGACCACCCCATTGTGGAGACGCTGCGGCAGAAGGCTGAGGCCGACAAGAATGATAAGGCAGTTAAGG
ACCTGGTGGTGCTGCTGTTTGAAACCGCCCTGCTATCTTCTGGCTTTTCCCTTGAGGATCCCCAGACCCACTCCAACCGC
ATCTATCGCATGATCAAGCTAGGTCTAGGTAAGTAGCTTTGGTACTTGGTGTGGCAAGGAGTTTGTGCAACTCGTCTCCT
CTATGGATTTGACTTAATGCTATTTGGTCAAGTCTCACATGGCTTAATTTTACTTCAGGTATTGATGAAGATGAAGTGGC
AGCAGAGGAACCCAATGCTGCAGTTCCTGATGAGATCCCCCCTCTCGAGGGCGATGAGGATGCGTCTCGCATGGAAGAAG
TCGATTAGGTTAGGAGTTCATAGTTGGAAAACTTGTGCCCTTGTATAGTGTCCCCATGGGCTCCCACTGCAGCCTCGAGT
GCCCCTGTCCCACCTGGCTCCCCCTGCTGGTGTCTAGTGTTTTTTTCCCTCTCCTGTCCTTGTGTTGAAGGCAGTAAACT
AAGGGTGTCAAGCCCCATTCCCTCTCTACTCTTGACAGCAGGATTGGATGTTGTGTATTGTGGTTTATTTTATTTTCTTC
ATTTTGTTCTGAAATTAAAGTATGCAAAATAAAGAATATGCCGTTT
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Primary source |
RefSeq : NM_007355.2 (GI:20149593)
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Name |
Heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1)
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
2567 nt
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Map |
6p12
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Location |
Chromosome 6 (NC_000006.11) strand : +
44214848...44214931 | 44216366...44216512 | 44217113...44217319 | 44217411...44217570 |
44217757...44217890 | 44218027...44218335 | 44218784...44218949 | 44219154...44219344 |
44219473...44219620 | 44219735...44220003 | 44220781...44221114 | 44221225...44221613 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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84
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84
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1
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Exon 2
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85
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231
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147
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1
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Exon 3
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232
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438
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207
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1
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Exon 4
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439
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598
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160
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1
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Exon 5
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599
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732
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134
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1
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Exon 6
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733
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1041
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309
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1
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Exon 7
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1042
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1207
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166
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1
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Exon 8
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1208
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1398
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191
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1
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Exon 9
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1399
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1546
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148
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1
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Exon 10
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1547
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1815
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269
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1
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Exon 11
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1816
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2149
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334
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1
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Exon 12
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2150
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2538
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389
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1
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Primary source |
NCBI : CCDS4909
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Nucleotide |
HSP90AB1, mRNA isoform 1[NM_007355.2] : 85...2259
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Length |
2175
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Location |
Chromosome 6 (NC_000006.11) strand : +
44216366...44216512 | 44217113...44217319 | 44217411...44217570 | 44217757...44217890 |
44218027...44218335 | 44218784...44218949 | 44219154...44219344 | 44219473...44219620 |
44219735...44220003 | 44220781...44221114 | 44221225...44221334 |
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Start codon |
1
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Translation |
NP_031381.2 |
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1 |
CTCCGGCGCA |
GTGTTGGGAC |
TGTCTGGGTA |
TCGGAAAGCA |
AGCCTACGTT |
GCTCACTATT |
ACGTATAATC |
CTTTTCTTTT |
|
81 |
CAAGATGCCT |
GAGGAAGTGC |
ACCATGGAGA |
GGAGGAGGTG |
GAGACTTTTG |
CCTTTCAGGC |
AGAAATTGCC |
CAACTCATGT |
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161 |
CCCTCATCAT |
CAATACCTTC |
TATTCCAACA |
AGGAGATTTT |
CCTTCGGGAG |
TTGATCTCTA |
ATGCTTCTGA |
TGCCTTGGAC |
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241 |
AAGATTCGCT |
ATGAGAGCCT |
GACAGACCCT |
TCGAAGTTGG |
ACAGTGGTAA |
AGAGCTGAAA |
ATTGACATCA |
TCCCCAACCC |
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321 |
TCAGGAACGT |
ACCCTGACTT |
TGGTAGACAC |
AGGCATTGGC |
ATGACCAAAG |
CTGATCTCAT |
AAATAATTTG |
GGAACCATTG |
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401 |
CCAAGTCTGG |
TACTAAAGCA |
TTCATGGAGG |
CTCTTCAGGC |
TGGTGCAGAC |
ATCTCCATGA |
TTGGGCAGTT |
TGGTGTTGGC |
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481 |
TTTTATTCTG |
CCTACTTGGT |
GGCAGAGAAA |
GTGGTTGTGA |
TCACAAAGCA |
CAACGATGAT |
GAACAGTATG |
CTTGGGAGTC |
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561 |
TTCTGCTGGA |
GGTTCCTTCA |
CTGTGCGTGC |
TGACCATGGT |
GAGCCCATTG |
GCAGGGGTAC |
CAAAGTGATC |
CTCCATCTTA |
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641 |
AAGAAGATCA |
GACAGAGTAC |
CTAGAAGAGA |
GGCGGGTCAA |
AGAAGTAGTG |
AAGAAGCATT |
CTCAGTTCAT |
AGGCTATCCC |
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721 |
ATCACCCTTT |
ATTTGGAGAA |
GGAACGAGAG |
AAGGAAATTA |
GTGATGATGA |
GGCAGAGGAA |
GAGAAAGGTG |
AGAAAGAAGA |
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801 |
GGAAGATAAA |
GATGATGAAG |
AAAAACCCAA |
GATCGAAGAT |
GTGGGTTCAG |
ATGAGGAGGA |
TGACAGCGGT |
AAGGATAAGA |
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881 |
AGAAGAAAAC |
TAAGAAGATC |
AAAGAGAAAT |
ACATTGATCA |
GGAAGAACTA |
AACAAGACCA |
AGCCTATTTG |
GACCAGAAAC |
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961 |
CCTGATGACA |
TCACCCAAGA |
GGAGTATGGA |
GAATTCTACA |
AGAGCCTCAC |
TAATGACTGG |
GAAGACCACT |
TGGCAGTCAA |
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1041 |
GCACTTTTCT |
GTAGAAGGTC |
AGTTGGAATT |
CAGGGCATTG |
CTATTTATTC |
CTCGTCGGGC |
TCCCTTTGAC |
CTTTTTGAGA |
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1121 |
ACAAGAAGAA |
AAAGAACAAC |
ATCAAACTCT |
ATGTCCGCCG |
TGTGTTCATC |
ATGGACAGCT |
GTGATGAGTT |
GATACCAGAG |
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1201 |
TATCTCAATT |
TTATCCGTGG |
TGTGGTTGAC |
TCTGAGGATC |
TGCCCCTGAA |
CATCTCCCGA |
GAAATGCTCC |
AGCAGAGCAA |
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1281 |
AATCTTGAAA |
GTCATTCGCA |
AAAACATTGT |
TAAGAAGTGC |
CTTGAGCTCT |
TCTCTGAGCT |
GGCAGAAGAC |
AAGGAGAATT |
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1361 |
ACAAGAAATT |
CTATGAGGCA |
TTCTCTAAAA |
ATCTCAAGCT |
TGGAATCCAC |
GAAGACTCCA |
CTAACCGCCG |
CCGCCTGTCT |
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1441 |
GAGCTGCTGC |
GCTATCATAC |
CTCCCAGTCT |
GGAGATGAGA |
TGACATCTCT |
GTCAGAGTAT |
GTTTCTCGCA |
TGAAGGAGAC |
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1521 |
ACAGAAGTCC |
ATCTATTACA |
TCACTGGTGA |
GAGCAAAGAG |
CAGGTGGCCA |
ACTCAGCTTT |
TGTGGAGCGA |
GTGCGGAAAC |
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1601 |
GGGGCTTCGA |
GGTGGTATAT |
ATGACCGAGC |
CCATTGACGA |
GTACTGTGTG |
CAGCAGCTCA |
AGGAATTTGA |
TGGGAAGAGC |
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1681 |
CTGGTCTCAG |
TTACCAAGGA |
GGGTCTGGAG |
CTGCCTGAGG |
ATGAGGAGGA |
GAAGAAGAAG |
ATGGAAGAGA |
GCAAGGCAAA |
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1761 |
GTTTGAGAAC |
CTCTGCAAGC |
TCATGAAAGA |
AATCTTAGAT |
AAGAAGGTTG |
AGAAGGTGAC |
AATCTCCAAT |
AGACTTGTGT |
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1841 |
CTTCACCTTG |
CTGCATTGTG |
ACCAGCACCT |
ACGGCTGGAC |
AGCCAATATG |
GAGCGGATCA |
TGAAAGCCCA |
GGCACTTCGG |
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1921 |
GACAACTCCA |
CCATGGGCTA |
TATGATGGCC |
AAAAAGCACC |
TGGAGATCAA |
CCCTGACCAC |
CCCATTGTGG |
AGACGCTGCG |
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2001 |
GCAGAAGGCT |
GAGGCCGACA |
AGAATGATAA |
GGCAGTTAAG |
GACCTGGTGG |
TGCTGCTGTT |
TGAAACCGCC |
CTGCTATCTT |
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2081 |
CTGGCTTTTC |
CCTTGAGGAT |
CCCCAGACCC |
ACTCCAACCG |
CATCTATCGC |
ATGATCAAGC |
TAGGTCTAGG |
TATTGATGAA |
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2161 |
GATGAAGTGG |
CAGCAGAGGA |
ACCCAATGCT |
GCAGTTCCTG |
ATGAGATCCC |
CCCTCTCGAG |
GGCGATGAGG |
ATGCGTCTCG |
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2241 |
CATGGAAGAA |
GTCGATTAGG |
TTAGGAGTTC |
ATAGTTGGAA |
AACTTGTGCC |
CTTGTATAGT |
GTCCCCATGG |
GCTCCCACTG |
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2321 |
CAGCCTCGAG |
TGCCCCTGTC |
CCACCTGGCT |
CCCCCTGCTG |
GTGTCTAGTG |
TTTTTTTCCC |
TCTCCTGTCC |
TTGTGTTGAA |
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2401 |
GGCAGTAAAC |
TAAGGGTGTC |
AAGCCCCATT |
CCCTCTCTAC |
TCTTGACAGC |
AGGATTGGAT |
GTTGTGTATT |
GTGGTTTATT |
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2481 |
TTATTTTCTT |
CATTTTGTTC |
TGAAATTAAA |
GTATGCAAAA |
TAAAGAATAT |
GCCGTTTTAA |
AAAAAAAAAA |
AAAAAAAAAA |
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2561 |
AAAAAAA |
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>gi|20149593|ref|NM_007355.2|Heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1)
CTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAGCAAGCCTACGTTGCTCACTATTACGTATAATCCTTTTCTTTT
CAAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACTCATGT
CCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGATGCCTTGGAC
AAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCATCCCCAACCC
TCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTG
CCAAGTCTGGTACTAAAGCATTCATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGC
TTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTC
TTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTA
AAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCC
ATCACCCTTTATTTGGAGAAGGAACGAGAGAAGGAAATTAGTGATGATGAGGCAGAGGAAGAGAAAGGTGAGAAAGAAGA
GGAAGATAAAGATGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGA
AGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAAC
CCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAA
GCACTTTTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGA
ACAAGAAGAAAAAGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGAG
TATCTCAATTTTATCCGTGGTGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAA
AATCTTGAAAGTCATTCGCAAAAACATTGTTAAGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATT
ACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGCTTGGAATCCACGAAGACTCCACTAACCGCCGCCGCCTGTCT
GAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCTGTCAGAGTATGTTTCTCGCATGAAGGAGAC
ACAGAAGTCCATCTATTACATCACTGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTGCGGAAAC
GGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGATGGGAAGAGC
CTGGTCTCAGTTACCAAGGAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAA
GTTTGAGAACCTCTGCAAGCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGGTGACAATCTCCAATAGACTTGTGT
CTTCACCTTGCTGCATTGTGACCAGCACCTACGGCTGGACAGCCAATATGGAGCGGATCATGAAAGCCCAGGCACTTCGG
GACAACTCCACCATGGGCTATATGATGGCCAAAAAGCACCTGGAGATCAACCCTGACCACCCCATTGTGGAGACGCTGCG
GCAGAAGGCTGAGGCCGACAAGAATGATAAGGCAGTTAAGGACCTGGTGGTGCTGCTGTTTGAAACCGCCCTGCTATCTT
CTGGCTTTTCCCTTGAGGATCCCCAGACCCACTCCAACCGCATCTATCGCATGATCAAGCTAGGTCTAGGTATTGATGAA
GATGAAGTGGCAGCAGAGGAACCCAATGCTGCAGTTCCTGATGAGATCCCCCCTCTCGAGGGCGATGAGGATGCGTCTCG
CATGGAAGAAGTCGATTAGGTTAGGAGTTCATAGTTGGAAAACTTGTGCCCTTGTATAGTGTCCCCATGGGCTCCCACTG
CAGCCTCGAGTGCCCCTGTCCCACCTGGCTCCCCCTGCTGGTGTCTAGTGTTTTTTTCCCTCTCCTGTCCTTGTGTTGAA
GGCAGTAAACTAAGGGTGTCAAGCCCCATTCCCTCTCTACTCTTGACAGCAGGATTGGATGTTGTGTATTGTGGTTTATT
TTATTTTCTTCATTTTGTTCTGAAATTAAAGTATGCAAAATAAAGAATATGCCGTTTTAAAAAAAAAAAAAAAAAAAAAA
AAAAAAA
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Exon number |
2
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Length |
147 nt
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Location |
Chromosome 6 (NC_000006.11) : 44216366...44216512 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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ATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACTCATGTCCCT
CATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGAT
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Exon number |
3
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Length |
207 nt
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Location |
Chromosome 6 (NC_000006.11) : 44217113...44217319 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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GCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCAT
CCCCAACCCTCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCATAAATAATTTGG
GAACCATTGCCAAGTCTGGTACTAAAGCATTCATGGAGGCTCTTCAG
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Exon number |
4
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Length |
160 nt
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Location |
Chromosome 6 (NC_000006.11) : 44217411...44217570 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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GCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCAGAGAAAGTGGTTGT
GATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATG
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Exon number |
5
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Length |
134 nt
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Location |
Chromosome 6 (NC_000006.11) : 44217757...44217890 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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GTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTC
AAAGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTAT
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Exon number |
6
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Length |
309 nt
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Location |
Chromosome 6 (NC_000006.11) : 44218027...44218335 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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TTGGAGAAGGAACGAGAGAAGGAAATTAGTGATGATGAGGCAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGATAAAGA
TGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTA
AGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATC
ACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAG
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Exon number |
7
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Length |
166 nt
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Location |
Chromosome 6 (NC_000006.11) : 44218784...44218949 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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CACTTTTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAA
CAAGAAGAAAAAGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGAGT
ATCTCA
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Exon number |
8
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Length |
191 nt
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Location |
Chromosome 6 (NC_000006.11) : 44219154...44219344 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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ATTTTATCCGTGGTGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAGAGCAAAATCTTG
AAAGTCATTCGCAAAAACATTGTTAAGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAA
ATTCTATGAGGCATTCTCTAAAAATCTCAAG
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Exon number |
9
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Length |
148 nt
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Location |
Chromosome 6 (NC_000006.11) : 44219473...44219620 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
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CTTGGAATCCACGAAGACTCCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGA
GATGACATCTCTGTCAGAGTATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTG
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Exon number |
10
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Length |
269 nt
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Location |
Chromosome 6 (NC_000006.11) : 44219735...44220003 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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GTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTATATATGACC
GAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGATGGGAAGAGCCTGGTCTCAGTTACCAAGGAGGGTCT
GGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAAGTTTGAGAACCTCTGCAAGCTCATGA
AAGAAATCTTAGATAAGAAGGTTGAGAAG
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Exon number |
11
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Length |
334 nt
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Location |
Chromosome 6 (NC_000006.11) : 44220781...44221114 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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GTGACAATCTCCAATAGACTTGTGTCTTCACCTTGCTGCATTGTGACCAGCACCTACGGCTGGACAGCCAATATGGAGCG
GATCATGAAAGCCCAGGCACTTCGGGACAACTCCACCATGGGCTATATGATGGCCAAAAAGCACCTGGAGATCAACCCTG
ACCACCCCATTGTGGAGACGCTGCGGCAGAAGGCTGAGGCCGACAAGAATGATAAGGCAGTTAAGGACCTGGTGGTGCTG
CTGTTTGAAACCGCCCTGCTATCTTCTGGCTTTTCCCTTGAGGATCCCCAGACCCACTCCAACCGCATCTATCGCATGAT
CAAGCTAGGTCTAG
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Exon number |
12
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Length |
389 nt
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Location |
Chromosome 6 (NC_000006.11) : 44221225...44221613 (+)
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Is part of |
HSP90AB1, mRNA isoform 1
(NM_007355.2)
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Sequence |
Show
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GTATTGATGAAGATGAAGTGGCAGCAGAGGAACCCAATGCTGCAGTTCCTGATGAGATCCCCCCTCTCGAGGGCGATGAG
GATGCGTCTCGCATGGAAGAAGTCGATTAGGTTAGGAGTTCATAGTTGGAAAACTTGTGCCCTTGTATAGTGTCCCCATG
GGCTCCCACTGCAGCCTCGAGTGCCCCTGTCCCACCTGGCTCCCCCTGCTGGTGTCTAGTGTTTTTTTCCCTCTCCTGTC
CTTGTGTTGAAGGCAGTAAACTAAGGGTGTCAAGCCCCATTCCCTCTCTACTCTTGACAGCAGGATTGGATGTTGTGTAT
TGTGGTTTATTTTATTTTCTTCATTTTGTTCTGAAATTAAAGTATGCAAAATAAAGAATATGCCGTTTT
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Primary source |
Uniprot : P08238
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Name |
Heat shock protein HSP 90-beta
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Alternative name(s) |
Heat shock 84 kDa
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Synonym(s) |
HSP 84 HSP 90 HSP84
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Organism |
Homo sapiens
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Length |
724 aa
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Protein existence |
---
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General annotation (Comments)
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Function
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Molecular chaperone. Has ATPase activity.
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Ptm
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Phosphorylated upon DNA damage, probably by ATM or ATR.
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Similarity
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Belongs to the heat shock protein 90 family.
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Subcellular location
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Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Subunit
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Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with DNAJC7.
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Biological process
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protein folding [GO:0006457]
response to unfolded protein [GO:0006986]
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]
positive regulation of nitric oxide biosynthetic process [GO:0045429]
regulation of interferon-gamma-mediated signaling pathway [GO:0060334]
regulation of type I interferon-mediated signaling pathway [GO:0060338]
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Cellular component
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melanosome [GO:0042470]
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Molecular function
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ATP binding [GO:0005524]
nitric-oxide synthase regulator activity [GO:0030235]
TPR domain binding [GO:0030911]
unfolded protein binding [GO:0051082]
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With
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Uniprot accession
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IntAct
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RPL7
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P18124
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EBI-352572,EBI-350806
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PPARG
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P37231
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EBI-352572,EBI-781384
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FLNA
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P21333
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EBI-352572,EBI-350432
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ACTN1
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P12814
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EBI-352572,EBI-351710
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NUMA1
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Q14980
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EBI-352572,EBI-521611
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NANS
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Q9NR45
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EBI-352572,EBI-709675
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PGK1
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P00558
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EBI-352572,EBI-709599
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RPL5
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P46777
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EBI-352572,EBI-358018
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EF2
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P13639
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EBI-352572,EBI-352560
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PSMD1
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Q99460
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EBI-352572,EBI-357874
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LDHA
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P00338
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EBI-352572,EBI-372327
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PSMB5
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P28074
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EBI-352572,EBI-357828
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RAF1
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P04049
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EBI-352572,EBI-365996
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XPO1
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O14980
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EBI-352572,EBI-355867
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HES4
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Q9HCC6
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EBI-352572,EBI-2680288
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HSPA1B
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P08107
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EBI-352572,EBI-629985
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STARD13
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Q9Y3M8
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EBI-352572,EBI-465487
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CHUK
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O15111
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EBI-352572,EBI-81249
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TCP1
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P17987
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EBI-352572,EBI-356553
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RPS3A
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P61247
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EBI-352572,EBI-352378
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FCHSD2
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O94868
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EBI-352572,EBI-1215612
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???
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Q9HB07
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EBI-352572,EBI-709754
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HSPH1
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Q92598
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EBI-352572,EBI-356829
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RPLP0
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P05388
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EBI-352572,EBI-354101
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RPSA
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P08865
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EBI-352572,EBI-354112
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UBA1
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P22314
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EBI-352572,EBI-709688
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MTHFD1
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P11586
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EBI-352572,EBI-709638
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RPS4X
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P62701
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EBI-352572,EBI-354303
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GNAI2
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P04899
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EBI-352572,EBI-353997
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PKM2
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P14618
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EBI-352572,EBI-353408
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ALDOA
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P04075
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EBI-352572,EBI-709613
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PRKDC
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P78527
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EBI-352572,EBI-352053
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IARS2
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Q9NSE4
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EBI-352572,EBI-1054770
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PSAT1
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Q9Y617
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EBI-352572,EBI-709652
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AARS
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P49588
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EBI-352572,EBI-709710
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G3P
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P04406
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EBI-352572,EBI-354056
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MDH1
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P40925
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EBI-352572,EBI-709625
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ACTG1
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P63261
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EBI-352572,EBI-351292
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???
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Q96KM8
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EBI-352572,EBI-373200
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TPM3
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P06753
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EBI-352572,EBI-355607
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EIF3H
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O15372
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EBI-352572,EBI-709735
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CHEK1
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O14757
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EBI-352572,
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RPS6
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P62753
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EBI-352572,EBI-356625
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FASN
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P49327
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EBI-352572,EBI-356658
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SPTAN1
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Q13813
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EBI-352572,EBI-351450
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MYH9
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P35579
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EBI-352572,EBI-350338
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Alternative product(s)
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Feature key |
Position
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Length
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Description
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Feature identifier
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Molecule processing |
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Initiator methionine
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1 - 1
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1
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Removed
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P08238-INIT_MET-1
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Natural variations |
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Natural variant site
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349 - 349
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1
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K -> E (in dbSNP:rs11538975)
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VAR_049624
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Amino acid modifications |
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Modified residue
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226 - 226
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1
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Phosphoserine
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P08238-MOD_RES-226
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Modified residue
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255 - 255
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1
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Phosphoserine
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P08238-MOD_RES-255
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Modified residue
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261 - 261
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1
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Phosphoserine
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P08238-MOD_RES-261
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Modified residue
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275 - 275
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1
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N6-acetyllysine
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P08238-MOD_RES-275
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Modified residue
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284 - 284
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1
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N6-acetyllysine
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P08238-MOD_RES-284
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Modified residue
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297 - 297
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1
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Phosphothreonine
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P08238-MOD_RES-297
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Modified residue
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305 - 305
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1
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Phosphotyrosine (By similarity)
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P08238-MOD_RES-305
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Modified residue
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307 - 307
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1
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Phosphoserine
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P08238-MOD_RES-307
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Modified residue
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354 - 354
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1
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N6-acetyllysine
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P08238-MOD_RES-354
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Modified residue
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399 - 399
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1
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N6-acetyllysine
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P08238-MOD_RES-399
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Modified residue
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402 - 402
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1
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N6-acetyllysine
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P08238-MOD_RES-402
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Modified residue
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435 - 435
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1
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N6-acetyllysine
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P08238-MOD_RES-435
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Modified residue
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452 - 452
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1
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Phosphoserine
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P08238-MOD_RES-452
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Modified residue
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481 - 481
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1
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N6-acetyllysine
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P08238-MOD_RES-481
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Modified residue
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484 - 484
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1
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Phosphotyrosine
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P08238-MOD_RES-484
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Modified residue
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532 - 532
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1
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Phosphoserine
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P08238-MOD_RES-532
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Modified residue
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568 - 568
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1
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N6-acetyllysine
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P08238-MOD_RES-568
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Modified residue
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624 - 624
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1
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N6-acetyllysine
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P08238-MOD_RES-624
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Modified residue
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718 - 718
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1
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Phosphoserine
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P08238-MOD_RES-718
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1 |
MPEEVHHGEE |
EVETFAFQAE |
IAQLMSLIIN |
TFYSNKEIFL |
RELISNASDA |
LDKIRYESLT |
DPSKLDSGKE |
LKIDIIPNPQ |
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81 |
ERTLTLVDTG |
IGMTKADLIN |
NLGTIAKSGT |
KAFMEALQAG |
ADISMIGQFG |
VGFYSAYLVA |
EKVVVITKHN |
DDEQYAWESS |
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161 |
AGGSFTVRAD |
HGEPIGRGTK |
VILHLKEDQT |
EYLEERRVKE |
VVKKHSQFIG |
YPITLYLEKE |
REKEISDDEA |
EEEKGEKEEE |
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241 |
DKDDEEKPKI |
EDVGSDEEDD |
SGKDKKKKTK |
KIKEKYIDQE |
ELNKTKPIWT |
RNPDDITQEE |
YGEFYKSLTN |
DWEDHLAVKH |
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321 |
FSVEGQLEFR |
ALLFIPRRAP |
FDLFENKKKK |
NNIKLYVRRV |
FIMDSCDELI |
PEYLNFIRGV |
VDSEDLPLNI |
SREMLQQSKI |
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401 |
LKVIRKNIVK |
KCLELFSELA |
EDKENYKKFY |
EAFSKNLKLG |
IHEDSTNRRR |
LSELLRYHTS |
QSGDEMTSLS |
EYVSRMKETQ |
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481 |
KSIYYITGES |
KEQVANSAFV |
ERVRKRGFEV |
VYMTEPIDEY |
CVQQLKEFDG |
KSLVSVTKEG |
LELPEDEEEK |
KKMEESKAKF |
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561 |
ENLCKLMKEI |
LDKKVEKVTI |
SNRLVSSPCC |
IVTSTYGWTA |
NMERIMKAQA |
LRDNSTMGYM |
MAKKHLEINP |
DHPIVETLRQ |
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641 |
KAEADKNDKA |
VKDLVVLLFE |
TALLSSGFSL |
EDPQTHSNRI |
YRMIKLGLGI |
DEDEVAAEEP |
NAAVPDEIPP |
LEGDEDASRM |
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721 |
EEVD |
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>sp|P08238|HS90B_human Heat shock protein HSP 90-beta
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQ
ERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS
AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKH
FSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKI
LKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKF
ENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQ
KAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
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