| (IRGM) immunity-related GTPase family, M [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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3719
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Official symbol
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IRGM
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Official name
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immunity-related GTPase family, M
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 5 (NC_000005.9) : 150226084...150228230 (+)
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Map
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5q33.1
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Length
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2147 nt
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NM_001145805.1
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IRGM, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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A1A4Y4
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Immunity-related GTPase family M protein
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Homo sapiens
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181 aa
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B3VEX0
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IRGM [submitted name]
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Homo sapiens
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181 aa
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| Synonyms |
MGC149264; MGC149263; LRG47; LRG-47; IRGM1; IFI1
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| Alternative name(s) |
immunity-related GTPase M; LRG-47-like protein; immunity-related GTPase family, M1
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| Summary |
Members of the p47 immunity-related GTPase (IRG) family, including IRGM, play an important role in the murine immune system; however, in humans this resistance system is greatly reduced. There is evidence that human IRGM plays a role in autophagy and control of intracellular mycobacteria (Bekpen et al., 2005; Singh et al., 2006 [PubMed 16888103]).[supplied by OMIM].
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Related Articles in PubMed
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Go to ensembl 
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| 1 |
GTAACCTGCT |
CAGGTCCCCT |
TCCATGCTGT |
GGAAGCTTTG |
TTTTTTTGCA |
CTTTGCAGTA |
AATCTTGCTG |
CTGCTCATTC |
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| 81 |
TTTGGGTCCA |
CACTGCCTTT |
ATGAGCTGTA |
ACACTCACCG |
TGAAGGTCTG |
CAGCATCACT |
CCTGAAACCT |
GTGAAACAAC |
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| 161 |
GAACCCCCCG |
GGGAGAAACG |
AACAACTCCA |
GACTCGCCGC |
CTGAAGAGCT |
GTAACTCTCA |
CTTCGAAGGT |
CTGCAGCTTC |
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| 241 |
GCTCCTGAGT |
CAGTGAAACC |
ACGAACCCAC |
CGGAAGGAAG |
AAACTCTGAA |
CACATCCAAA |
CATCAGAAGG |
AACAAACTCC |
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| 321 |
GGACACGCAG |
CCTTTAAGAA |
TTGTAACACT |
CACCGCGAGG |
GTCCGTGGCT |
TCATTCTTGA |
AGTCAGTGAG |
ACGAAGAACC |
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| 401 |
CACCAATTCC |
GGTAGGAGTA |
GGAAATCACA |
TCACCTTCTT |
TTAATCAGTC |
TCAAATACCT |
GGCCCCTTGT |
GGAACCTGCA |
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| 481 |
AGAGCCAGGT |
TTGGCGAATG |
CAATGATAAG |
CAATTGTCTA |
ATCACTGCCT |
TGAAAAAGAG |
CAGAGCATTT |
GAGTATGCTG |
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| 561 |
TCTCCTCCTC |
TCCCTCACTT |
CAGTTGGGCC |
CAACATGACA |
GTCTTAATGG |
AAGCTCGGGG |
GTCAAAGGCT |
GGTGGCTTAC |
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| 641 |
TTCACGTATA |
TTGCAGCATT |
TCAGTACTGC |
TCTGCACGTG |
TGCTCCCCCG |
CCTGATGAGG |
TAAGTGTTAA |
ACAGGGATGA |
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| 721 |
TCACAGCTTC |
AAGTAAGCAA |
TGGGAATTGG |
ATGTTTTATG |
TCCTCTGGCG |
CCATCTTCAG |
CAGAGAAATA |
TATAGGTCAC |
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| 801 |
TTTTACTTGT |
CTGGTTTTGG |
TCTTGAAATA |
TGTACTGAAA |
CTTGTGAAGG |
AGCAGACCTA |
TATTAGGATA |
GAGTAAAAGA |
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| 881 |
GGGAAAGACA |
AAAACCTCTT |
GGGCTTTTCA |
GGAGACTTGG |
TTCATTCTCT |
GCTTTTCAAG |
CCATCTCATG |
GCCACATGCC |
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| 961 |
TGCTTTGGAG |
GCTGACTCGG |
AGGCACAACC |
GGCCTCAGGG |
CGTTCCTCAG |
GGACCCTACC |
TTTCTTGCTC |
CCTGAAGAAA |
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| 1041 |
TGTGCACATT |
GCTTGAATAA |
AAACAATCAA |
AGAACACTCA |
GTCAAGATCG |
TCTGCTGCAG |
TCTTCGTTGA |
GGGCTGGGGA |
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| 1121 |
TGCTAAAAGT |
CAGATGATTC |
ATGTGTACCC |
TGTCCATCCT |
AACTCACCTG |
CTCTTCTACT |
TCCGCAGCTT |
ACTCCAGTGC |
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| 1201 |
CCACAGATAC |
GACAGAGTGT |
CCCAAGTGCC |
CCTCACACTC |
TATTAGCTGC |
ATCCTTAACC |
TCTTTTTGCC |
ACACCATAAG |
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| 1281 |
CATTGGGTTT |
TGTTTGTTTT |
GAGATGGAGT |
CTTGCTCTGT |
TGCCAGGCTG |
GAGTGCAATG |
GCGTGATCTC |
AGCTCACTGC |
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| 1361 |
AATATCTGCG |
TCCAGGGTTC |
AAGCGATTCC |
CCTGCCTCAG |
CCTCCTGTAT |
TAGCTGGGAC |
TACAGGCGCA |
CACCACCACG |
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| 1441 |
CGCAGCTAAT |
TTTTTTGTAT |
TTTAGTAGAG |
AAGGTTTCAC |
GATGTTGGCC |
AGGATGGTCT |
CAATCTCCTG |
ACCTCGTGAT |
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| 1521 |
CTGCTCGCCT |
CGGCCTTCCA |
AAGTGCTGGG |
ATTACAGGCA |
TGAGCCACGG |
CGCCTGGCCA |
GCATTGGGGT |
ATTTTATTGA |
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| 1601 |
AGATGGAAGC |
CATGAATGTT |
GAGAAAGCCT |
CAGCAGATGG |
GAACTTGCCA |
GAGGTGATCT |
CTAACATCAA |
GGAGACTCTG |
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| 1681 |
AAGATAGTGT |
CCAGGACACC |
AGTTAACATC |
ACTATGGCAG |
GGGACTCTGG |
CAATGGGATG |
TCCACCTTCA |
TCAGTGCCCT |
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| 1761 |
TCGAAACACA |
GGACATGAGG |
GTAAGGCCTC |
ACCTCCTACT |
GAGCTGGTAA |
AAGCTACCCA |
AAGATGTGCC |
TCCTATTTCT |
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| 1841 |
CTTCCCACTT |
TTCAAATGTG |
GTGTTGTGGG |
ACCTGCCTGG |
CACAGGGTCT |
GCCACCACAA |
CCCTGGAGAA |
CTACCTGATG |
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| 1921 |
GAAATGCAGT |
TCAACCGGTA |
TGACTTCATC |
ATGGTTGCAT |
CTGCACAATT |
CAGCATGAAT |
CATGTGATGC |
TTGCCAAAAC |
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| 2001 |
CGCTGAGGAC |
ATGGGAAAGA |
AGTTCTACAT |
TGTCTGGACC |
AAGCTAGACA |
TGGACCTCAG |
CACAGGTGCC |
CTCCCAGAAG |
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| 2081 |
TGCAGCTACT |
GCAGATCAGA |
GAAAATGTCC |
TGGAAAATCT |
CCAGAAGGAG |
CGGGTATGTG |
AATACTA |
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>ref|Gene_ID:345611|IRGM|NC_000005.9:150226084...150228230 (+)
GTAACCTGCTCAGGTCCCCTTCCATGCTGTGGAAGCTTTGTTTTTTTGCACTTTGCAGTAAATCTTGCTGCTGCTCATTC
TTTGGGTCCACACTGCCTTTATGAGCTGTAACACTCACCGTGAAGGTCTGCAGCATCACTCCTGAAACCTGTGAAACAAC
GAACCCCCCGGGGAGAAACGAACAACTCCAGACTCGCCGCCTGAAGAGCTGTAACTCTCACTTCGAAGGTCTGCAGCTTC
GCTCCTGAGTCAGTGAAACCACGAACCCACCGGAAGGAAGAAACTCTGAACACATCCAAACATCAGAAGGAACAAACTCC
GGACACGCAGCCTTTAAGAATTGTAACACTCACCGCGAGGGTCCGTGGCTTCATTCTTGAAGTCAGTGAGACGAAGAACC
CACCAATTCCGGTAGGAGTAGGAAATCACATCACCTTCTTTTAATCAGTCTCAAATACCTGGCCCCTTGTGGAACCTGCA
AGAGCCAGGTTTGGCGAATGCAATGATAAGCAATTGTCTAATCACTGCCTTGAAAAAGAGCAGAGCATTTGAGTATGCTG
TCTCCTCCTCTCCCTCACTTCAGTTGGGCCCAACATGACAGTCTTAATGGAAGCTCGGGGGTCAAAGGCTGGTGGCTTAC
TTCACGTATATTGCAGCATTTCAGTACTGCTCTGCACGTGTGCTCCCCCGCCTGATGAGGTAAGTGTTAAACAGGGATGA
TCACAGCTTCAAGTAAGCAATGGGAATTGGATGTTTTATGTCCTCTGGCGCCATCTTCAGCAGAGAAATATATAGGTCAC
TTTTACTTGTCTGGTTTTGGTCTTGAAATATGTACTGAAACTTGTGAAGGAGCAGACCTATATTAGGATAGAGTAAAAGA
GGGAAAGACAAAAACCTCTTGGGCTTTTCAGGAGACTTGGTTCATTCTCTGCTTTTCAAGCCATCTCATGGCCACATGCC
TGCTTTGGAGGCTGACTCGGAGGCACAACCGGCCTCAGGGCGTTCCTCAGGGACCCTACCTTTCTTGCTCCCTGAAGAAA
TGTGCACATTGCTTGAATAAAAACAATCAAAGAACACTCAGTCAAGATCGTCTGCTGCAGTCTTCGTTGAGGGCTGGGGA
TGCTAAAAGTCAGATGATTCATGTGTACCCTGTCCATCCTAACTCACCTGCTCTTCTACTTCCGCAGCTTACTCCAGTGC
CCACAGATACGACAGAGTGTCCCAAGTGCCCCTCACACTCTATTAGCTGCATCCTTAACCTCTTTTTGCCACACCATAAG
CATTGGGTTTTGTTTGTTTTGAGATGGAGTCTTGCTCTGTTGCCAGGCTGGAGTGCAATGGCGTGATCTCAGCTCACTGC
AATATCTGCGTCCAGGGTTCAAGCGATTCCCCTGCCTCAGCCTCCTGTATTAGCTGGGACTACAGGCGCACACCACCACG
CGCAGCTAATTTTTTTGTATTTTAGTAGAGAAGGTTTCACGATGTTGGCCAGGATGGTCTCAATCTCCTGACCTCGTGAT
CTGCTCGCCTCGGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACGGCGCCTGGCCAGCATTGGGGTATTTTATTGA
AGATGGAAGCCATGAATGTTGAGAAAGCCTCAGCAGATGGGAACTTGCCAGAGGTGATCTCTAACATCAAGGAGACTCTG
AAGATAGTGTCCAGGACACCAGTTAACATCACTATGGCAGGGGACTCTGGCAATGGGATGTCCACCTTCATCAGTGCCCT
TCGAAACACAGGACATGAGGGTAAGGCCTCACCTCCTACTGAGCTGGTAAAAGCTACCCAAAGATGTGCCTCCTATTTCT
CTTCCCACTTTTCAAATGTGGTGTTGTGGGACCTGCCTGGCACAGGGTCTGCCACCACAACCCTGGAGAACTACCTGATG
GAAATGCAGTTCAACCGGTATGACTTCATCATGGTTGCATCTGCACAATTCAGCATGAATCATGTGATGCTTGCCAAAAC
CGCTGAGGACATGGGAAAGAAGTTCTACATTGTCTGGACCAAGCTAGACATGGACCTCAGCACAGGTGCCCTCCCAGAAG
TGCAGCTACTGCAGATCAGAGAAAATGTCCTGGAAAATCTCCAGAAGGAGCGGGTATGTGAATACTA
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| Primary source |
RefSeq : NM_001145805.1 (GI:224809575)
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| Name |
Immunity-related GTPase family, M (IRGM)
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| Type of transcript |
mRNA
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| Organism |
Homo sapiens
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| Length |
1659 nt
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| Map |
5q33.1
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| Location |
Chromosome 5 (NC_000005.9) strand : +
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| Exon(s) |
Start |
End |
Length |
is coding |
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Exon 1
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1
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698
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698
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1
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Exon 2
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699
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1659
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961
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1
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| ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
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| Primary source |
NCBI : CCDS47313
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| Nucleotide |
IRGM, mRNA isoform 1[NM_001145805.1] : 1114...1659
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| Length |
546
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| Location |
Chromosome 5 (NC_000005.9) strand : +
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| Start codon |
1
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| Translation |
NP_001139277.1 |
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| 1 |
TAACCTGCTC |
AGGTCCCCTT |
CCATGCTGTG |
GAAGCTTTGT |
TTTTTTGCAC |
TTTGCAGTAA |
ATCTTGCTGC |
TGCTCATTCT |
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| 81 |
TTGGGTCCAC |
ACTGCCTTTA |
TGAGCTGTAA |
CACTCACCGT |
GAAGGTCTGC |
AGCATCACTC |
CTGAAACCTG |
TGAAACAACG |
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| 161 |
AACCCCCCGG |
GGAGAAACGA |
ACAACTCCAG |
ACTCGCCGCC |
TGAAGAGCTG |
TAACTCTCAC |
TTCGAAGGTC |
TGCAGCTTCG |
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| 241 |
CTCCTGAGTC |
AGTGAAACCA |
CGAACCCACC |
GGAAGGAAGA |
AACTCTGAAC |
ACATCCAAAC |
ATCAGAAGGA |
ACAAACTCCG |
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| 321 |
GACACGCAGC |
CTTTAAGAAT |
TGTAACACTC |
ACCGCGAGGG |
TCCGTGGCTT |
CATTCTTGAA |
GTCAGTGAGA |
CGAAGAACCC |
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| 401 |
ACCAATTCCG |
GTAGGAGTAG |
GAAATCACAT |
CACCTTCTTT |
TAATCAGTCT |
CAAATACCTG |
GCCCCTTGTG |
GAACCTGCAA |
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| 481 |
GAGCCAGGTT |
TGGCGAATGC |
AATGATAAGC |
AATTGTCTAA |
TCACTGCCTT |
GAAAAAGAGC |
AGAGCATTTG |
AGTATGCTGT |
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| 561 |
CTCCTCCTCT |
CCCTCACTTC |
AGTTGGGCCC |
AACATGACAG |
TCTTAATGGA |
AGCTCGGGGG |
TCAAAGGCTG |
GTGGCTTACT |
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| 641 |
TCACGTATAT |
TGCAGCATTT |
CAGTACTGCT |
CTGCACGTGT |
GCTCCCCCGC |
CTGATGAGCT |
TACTCCAGTG |
CCCACAGATA |
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| 721 |
CGACAGAGTG |
TCCCAAGTGC |
CCCTCACACT |
CTATTAGCTG |
CATCCTTAAC |
CTCTTTTTGC |
CACACCATAA |
GCATTGGGTT |
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| 801 |
TTGTTTGTTT |
TGAGATGGAG |
TCTTGCTCTG |
TTGCCAGGCT |
GGAGTGCAAT |
GGCGTGATCT |
CAGCTCACTG |
CAATATCTGC |
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| 881 |
GTCCAGGGTT |
CAAGCGATTC |
CCCTGCCTCA |
GCCTCCTGTA |
TTAGCTGGGA |
CTACAGGCGC |
ACACCACCAC |
GCGCAGCTAA |
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| 961 |
TTTTTTTGTA |
TTTTAGTAGA |
GAAGGTTTCA |
CGATGTTGGC |
CAGGATGGTC |
TCAATCTCCT |
GACCTCGTGA |
TCTGCTCGCC |
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| 1041 |
TCGGCCTTCC |
AAAGTGCTGG |
GATTACAGGC |
ATGAGCCACG |
GCGCCTGGCC |
AGCATTGGGG |
TATTTTATTG |
AAGATGGAAG |
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| 1121 |
CCATGAATGT |
TGAGAAAGCC |
TCAGCAGATG |
GGAACTTGCC |
AGAGGTGATC |
TCTAACATCA |
AGGAGACTCT |
GAAGATAGTG |
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| 1201 |
TCCAGGACAC |
CAGTTAACAT |
CACTATGGCA |
GGGGACTCTG |
GCAATGGGAT |
GTCCACCTTC |
ATCAGTGCCC |
TTCGAAACAC |
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| 1281 |
AGGACATGAG |
GGTAAGGCCT |
CACCTCCTAC |
TGAGCTGGTA |
AAAGCTACCC |
AAAGATGTGC |
CTCCTATTTC |
TCTTCCCACT |
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| 1361 |
TTTCAAATGT |
GGTGTTGTGG |
GACCTGCCTG |
GCACAGGGTC |
TGCCACCACA |
ACCCTGGAGA |
ACTACCTGAT |
GGAAATGCAG |
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| 1441 |
TTCAACCGGT |
ATGACTTCAT |
CATGGTTGCA |
TCTGCACAAT |
TCAGCATGAA |
TCATGTGATG |
CTTGCCAAAA |
CCGCTGAGGA |
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| 1521 |
CATGGGAAAG |
AAGTTCTACA |
TTGTCTGGAC |
CAAGCTAGAC |
ATGGACCTCA |
GCACAGGTGC |
CCTCCCAGAA |
GTGCAGCTAC |
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| 1601 |
TGCAGATCAG |
AGAAAATGTC |
CTGGAAAATC |
TCCAGAAGGA |
GCGGGTATGT |
GAATACTAA |
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>gi|224809575|ref|NM_001145805.1|Immunity-related GTPase family, M (IRGM)
TAACCTGCTCAGGTCCCCTTCCATGCTGTGGAAGCTTTGTTTTTTTGCACTTTGCAGTAAATCTTGCTGCTGCTCATTCT
TTGGGTCCACACTGCCTTTATGAGCTGTAACACTCACCGTGAAGGTCTGCAGCATCACTCCTGAAACCTGTGAAACAACG
AACCCCCCGGGGAGAAACGAACAACTCCAGACTCGCCGCCTGAAGAGCTGTAACTCTCACTTCGAAGGTCTGCAGCTTCG
CTCCTGAGTCAGTGAAACCACGAACCCACCGGAAGGAAGAAACTCTGAACACATCCAAACATCAGAAGGAACAAACTCCG
GACACGCAGCCTTTAAGAATTGTAACACTCACCGCGAGGGTCCGTGGCTTCATTCTTGAAGTCAGTGAGACGAAGAACCC
ACCAATTCCGGTAGGAGTAGGAAATCACATCACCTTCTTTTAATCAGTCTCAAATACCTGGCCCCTTGTGGAACCTGCAA
GAGCCAGGTTTGGCGAATGCAATGATAAGCAATTGTCTAATCACTGCCTTGAAAAAGAGCAGAGCATTTGAGTATGCTGT
CTCCTCCTCTCCCTCACTTCAGTTGGGCCCAACATGACAGTCTTAATGGAAGCTCGGGGGTCAAAGGCTGGTGGCTTACT
TCACGTATATTGCAGCATTTCAGTACTGCTCTGCACGTGTGCTCCCCCGCCTGATGAGCTTACTCCAGTGCCCACAGATA
CGACAGAGTGTCCCAAGTGCCCCTCACACTCTATTAGCTGCATCCTTAACCTCTTTTTGCCACACCATAAGCATTGGGTT
TTGTTTGTTTTGAGATGGAGTCTTGCTCTGTTGCCAGGCTGGAGTGCAATGGCGTGATCTCAGCTCACTGCAATATCTGC
GTCCAGGGTTCAAGCGATTCCCCTGCCTCAGCCTCCTGTATTAGCTGGGACTACAGGCGCACACCACCACGCGCAGCTAA
TTTTTTTGTATTTTAGTAGAGAAGGTTTCACGATGTTGGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCTGCTCGCC
TCGGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACGGCGCCTGGCCAGCATTGGGGTATTTTATTGAAGATGGAAG
CCATGAATGTTGAGAAAGCCTCAGCAGATGGGAACTTGCCAGAGGTGATCTCTAACATCAAGGAGACTCTGAAGATAGTG
TCCAGGACACCAGTTAACATCACTATGGCAGGGGACTCTGGCAATGGGATGTCCACCTTCATCAGTGCCCTTCGAAACAC
AGGACATGAGGGTAAGGCCTCACCTCCTACTGAGCTGGTAAAAGCTACCCAAAGATGTGCCTCCTATTTCTCTTCCCACT
TTTCAAATGTGGTGTTGTGGGACCTGCCTGGCACAGGGTCTGCCACCACAACCCTGGAGAACTACCTGATGGAAATGCAG
TTCAACCGGTATGACTTCATCATGGTTGCATCTGCACAATTCAGCATGAATCATGTGATGCTTGCCAAAACCGCTGAGGA
CATGGGAAAGAAGTTCTACATTGTCTGGACCAAGCTAGACATGGACCTCAGCACAGGTGCCCTCCCAGAAGTGCAGCTAC
TGCAGATCAGAGAAAATGTCCTGGAAAATCTCCAGAAGGAGCGGGTATGTGAATACTAA
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| Exon number |
1
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| Length |
698 nt
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| Location |
Chromosome 5 (NC_000005.9) : 150226084...150226781 (+)
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| Is part of |
IRGM, mRNA isoform 1
(NM_001145805.1)
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| Sequence |
Show
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TAACCTGCTCAGGTCCCCTTCCATGCTGTGGAAGCTTTGTTTTTTTGCACTTTGCAGTAAATCTTGCTGCTGCTCATTCT
TTGGGTCCACACTGCCTTTATGAGCTGTAACACTCACCGTGAAGGTCTGCAGCATCACTCCTGAAACCTGTGAAACAACG
AACCCCCCGGGGAGAAACGAACAACTCCAGACTCGCCGCCTGAAGAGCTGTAACTCTCACTTCGAAGGTCTGCAGCTTCG
CTCCTGAGTCAGTGAAACCACGAACCCACCGGAAGGAAGAAACTCTGAACACATCCAAACATCAGAAGGAACAAACTCCG
GACACGCAGCCTTTAAGAATTGTAACACTCACCGCGAGGGTCCGTGGCTTCATTCTTGAAGTCAGTGAGACGAAGAACCC
ACCAATTCCGGTAGGAGTAGGAAATCACATCACCTTCTTTTAATCAGTCTCAAATACCTGGCCCCTTGTGGAACCTGCAA
GAGCCAGGTTTGGCGAATGCAATGATAAGCAATTGTCTAATCACTGCCTTGAAAAAGAGCAGAGCATTTGAGTATGCTGT
CTCCTCCTCTCCCTCACTTCAGTTGGGCCCAACATGACAGTCTTAATGGAAGCTCGGGGGTCAAAGGCTGGTGGCTTACT
TCACGTATATTGCAGCATTTCAGTACTGCTCTGCACGTGTGCTCCCCCGCCTGATGAG
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| Exon number |
2
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| Length |
961 nt
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| Location |
Chromosome 5 (NC_000005.9) : 150227270...150228230 (+)
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| Is part of |
IRGM, mRNA isoform 1
(NM_001145805.1)
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| Sequence |
Show
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CTTACTCCAGTGCCCACAGATACGACAGAGTGTCCCAAGTGCCCCTCACACTCTATTAGCTGCATCCTTAACCTCTTTTT
GCCACACCATAAGCATTGGGTTTTGTTTGTTTTGAGATGGAGTCTTGCTCTGTTGCCAGGCTGGAGTGCAATGGCGTGAT
CTCAGCTCACTGCAATATCTGCGTCCAGGGTTCAAGCGATTCCCCTGCCTCAGCCTCCTGTATTAGCTGGGACTACAGGC
GCACACCACCACGCGCAGCTAATTTTTTTGTATTTTAGTAGAGAAGGTTTCACGATGTTGGCCAGGATGGTCTCAATCTC
CTGACCTCGTGATCTGCTCGCCTCGGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACGGCGCCTGGCCAGCATTGG
GGTATTTTATTGAAGATGGAAGCCATGAATGTTGAGAAAGCCTCAGCAGATGGGAACTTGCCAGAGGTGATCTCTAACAT
CAAGGAGACTCTGAAGATAGTGTCCAGGACACCAGTTAACATCACTATGGCAGGGGACTCTGGCAATGGGATGTCCACCT
TCATCAGTGCCCTTCGAAACACAGGACATGAGGGTAAGGCCTCACCTCCTACTGAGCTGGTAAAAGCTACCCAAAGATGT
GCCTCCTATTTCTCTTCCCACTTTTCAAATGTGGTGTTGTGGGACCTGCCTGGCACAGGGTCTGCCACCACAACCCTGGA
GAACTACCTGATGGAAATGCAGTTCAACCGGTATGACTTCATCATGGTTGCATCTGCACAATTCAGCATGAATCATGTGA
TGCTTGCCAAAACCGCTGAGGACATGGGAAAGAAGTTCTACATTGTCTGGACCAAGCTAGACATGGACCTCAGCACAGGT
GCCCTCCCAGAAGTGCAGCTACTGCAGATCAGAGAAAATGTCCTGGAAAATCTCCAGAAGGAGCGGGTATGTGAATACTA
A
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| Primary source |
Uniprot : A1A4Y4
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| Name |
Immunity-related GTPase family M protein
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| Alternative name(s) |
Immunity-related GTPase family M protein 1
Interferon-inducible protein 1
LPS-stimulated RAW 264.7 macrophage protein 47 homolog
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| Synonym(s) |
LRG-47
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| Organism |
Homo sapiens
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| Length |
181 aa
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| Protein existence |
---
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General annotation (Comments)
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top
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Disease
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Defects in IRGM are associated with susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. CD is commonly classified as an autoimmune disease. The causal variants do not affect the protein sequence but may lie in regulatory regions and alter its expression.
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Function
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Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
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Induction
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Not up-regulated by IFNG.
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Similarity
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Belongs to the interferon-inducible GTPase family.
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Subcellular location
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Golgi apparatus membrane (By similarity). Cell membrane (By similarity). Cytoplasmic vesicle, phagosome membrane (By similarity). Cytoplasmic vesicle, autophagosome membrane (By similarity). Note=Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi (By similarity).
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Tissue specificity
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Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
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Biological process
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autophagy [GO:0006914]
inflammatory response [GO:0006954]
innate immune response [GO:0045087]
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Cellular component
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Golgi membrane [GO:0000139]
autophagic vacuole membrane [GO:0000421]
plasma membrane [GO:0005886]
phagocytic vesicle membrane [GO:0030670]
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Molecular function
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GTP binding [GO:0005525]
hydrolase activity, acting on acid anhydrides [GO:0016817]
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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Region
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Nucleotide binding
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41 - 48
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8
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GTP (By similarity)
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A1A4Y4-NP_BIND-41
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Nucleotide binding
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66 - 70
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5
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GTP (By similarity)
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A1A4Y4-NP_BIND-66
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Natural variations
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Natural variant site
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17 - 17
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1
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E -> D
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VAR_039899
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Natural variant site
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94 - 94
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1
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T -> K
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VAR_039900
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| 1 |
MEAMNVEKAS |
ADGNLPEVIS |
NIKETLKIVS |
RTPVNITMAG |
DSGNGMSTFI |
SALRNTGHEG |
KASPPTELVK |
ATQRCASYFS |
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SHFSNVVLWD |
LPGTGSATTT |
LENYLMEMQF |
NRYDFIMVAS |
AQFSMNHVML |
AKTAEDMGKK |
FYIVWTKLDM |
DLSTGALPEV |
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QLLQIRENVL |
ENLQKERVCE |
Y |
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>sp|A1A4Y4|IRGM_human Immunity-related GTPase family M protein
MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFS
SHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEV
QLLQIRENVLENLQKERVCEY
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| Primary source |
Uniprot : B3VEX0
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| Name |
IRGM [submitted name]
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| Alternative name(s) |
Immunity-related GTPase M [submitted name]
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| Synonym(s) |
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| Organism |
Homo sapiens
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| Length |
181 aa
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| Protein existence |
---
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General annotation (Comments)
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top
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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| 1 |
MEAMNVEKAS |
ADGNLPEVIS |
NIKETLKIVS |
RTPVNITMAG |
DSGNGMSTFI |
SALRNTGHEG |
KASPPTELVK |
ATQRCASYFS |
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SHFSNVVLWD |
LPGTGSATTT |
LENYLMEMQF |
NRYDFIMVAS |
AQFSMNHVML |
AKTAEDMGKK |
FYIVWTKLDM |
DLSTGALPEV |
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QLLQIRENVL |
ENLQKERVCE |
Y |
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>sp|B3VEX0|B3VEX0_human IRGM [submitted name]
MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFS
SHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEV
QLLQIRENVLENLQKERVCEY
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