(IFNG) interferon, gamma [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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6521
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Official symbol
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IFNG
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Official name
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interferon, gamma
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 12 (NC_000012.11) : 68548549...68553520 (-)
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Map
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12q14
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Length
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4972 nt
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NM_000619.2
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IFNG, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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P01579
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Interferon gamma
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Homo sapiens
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166 aa
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Summary |
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
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Related Articles in PubMed
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Go to ensembl
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1 |
ACATTGTTCT |
GATCATCTGA |
AGATCAGCTA |
TTAGAAGAGA |
AAGATCAGTT |
AAGTCCTTTG |
GACCTGATCA |
GCTTGATACA |
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81 |
AGAACTACTG |
ATTTCAACTT |
CTTTGGCTTA |
ATTCTCTCGG |
AAACGATGAA |
ATATACAAGT |
TATATCTTGG |
CTTTTCAGCT |
|
161 |
CTGCATCGTT |
TTGGGTTCTC |
TTGGCTGTTA |
CTGCCAGGAC |
CCATATGTAA |
AAGAAGCAGA |
AAACCTTAAG |
AAATATTTTG |
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241 |
TAAGTATGAC |
TTTTTAATAG |
TACTTGTTTG |
TGGTTGAAAA |
TGACTGAATA |
TCGACTTGCT |
GTAGCATCTC |
TGATAGGCTG |
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321 |
TCATCTCTTG |
TAGGCAGTCA |
TTTTGAGATT |
TGGTGTTATT |
TTGTTAATTA |
TTGACTAGAT |
GAGTTCCTTG |
ACTAAATAAT |
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401 |
CTAGATATTG |
TTTTAACCTT |
CTGCTCAGTT |
TGTATAGAGA |
CTTAAAAGGG |
ATTTATGAAT |
TTTCCAAAAG |
ATGGGCATAA |
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481 |
TATGGGTATG |
AAGCATAATG |
ATGTTAATAA |
TTTTGTGGTG |
GGAACTCATT |
CAGTTGTGAT |
AGTCAAGGAG |
TATGCAGATT |
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561 |
GAAAAAAATG |
ATTGGTTATT |
AGTTTTTGAC |
TTCTCAGACT |
CTAAGGTCAA |
GATTAGCATT |
AAAAAGGTAA |
TAGGAAATGT |
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641 |
TTACAAATTA |
AAGTCAAAAA |
GGTCCTTAAA |
GCTTTGGCTT |
AAAAAAATAA |
CTGATAGGTG |
ATTTTCTCCA |
AAAAGTGATT |
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721 |
TCAACATTCT |
GCTTCTCTAT |
CTATATTACT |
TGTGAAGTAT |
TCCGGAACTT |
CGTTGCTCAC |
TGGGATTTTG |
GAAGAATTAT |
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801 |
GATTCTGGCT |
AAGGAATGTT |
TAAAAATTTT |
AAGTGAATTT |
TTTGAGTTTC |
TTTTAAAATT |
TTATTGATGG |
TTAATGAAAA |
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881 |
GTTTTTACAT |
TTTAAATATT |
TCATTATTTG |
TTTAAAACTT |
AGCTGTTATA |
ATTATAGCTG |
TCATAATAAT |
ATTCAGACAT |
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961 |
TCACAATTGA |
TTTTATTCTT |
ACAACACAAA |
ATCAAATCAC |
ACACACACAC |
ACACACACAC |
ACACACTCGC |
ACATGTTTGG |
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1041 |
AACTATCTTT |
TAAAGCTCGT |
ATAATAATAC |
CCTACAGGAA |
GGCACAGTAG |
ATGTAATAGA |
AACCTGTACC |
ATTGGGGGGC |
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1121 |
AGTATTTTAT |
AGTGGGGTGG |
CTTTGCTGTT |
TTTTGTTTTT |
GTATTTTTTA |
GCCTAGCTTG |
AAAATACTTT |
CTTTAGCTTA |
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1201 |
CTATAGTTTT |
TGGGACCTTT |
GGAGTATCAG |
CTTTGTTGAG |
CTCATTTGTG |
ACATTGCAAT |
TTAATGGTTA |
TATTGGGAAA |
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1281 |
TAAAAAAGCT |
AAAAGAACAT |
AATAGTCTTT |
GTCTATATCT |
CACATAAGCC |
TTTTGGGAAT |
ACTTATTGTT |
AGAACTAAGC |
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1361 |
AGAAGAGTTG |
AAAAGGAAAT |
CAGTGAATAT |
TGTCACATCT |
GAGTTCAATG |
AAACTTGAAA |
TATATTTTTA |
AGGCAATTTA |
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1441 |
TGGGCTAATT |
GTAAACCAAT |
TTTTTCTTTT |
TTTTTTTTTA |
GAATGCAGGT |
CATTCAGATG |
TAGCGGATAA |
TGGAACTCTT |
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1521 |
TTCTTAGGCA |
TTTTGAAGAA |
TTGGAAAGAG |
GTAAGCTGAA |
TATTCCCATT |
TGGCTAATTT |
TCCTGTTGCT |
TGCTTTCTGA |
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1601 |
TGGATAAATT |
CACATCATCC |
TCTGTTTGTG |
CTCTTTCCTT |
CCAAGGAGAG |
TGACAGAAAA |
ATAATGCAGA |
GCCAAATTGT |
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1681 |
CTCCTTTTAC |
TTCAAACTTT |
TTAAAAACTT |
TAAAGATGAC |
CAGAGCATCC |
AAAAGAGTGT |
GGAGACCATC |
AAGGAAGACA |
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1761 |
TGAATGTCAA |
GTTTTTCAAT |
AGCAACAAAA |
AGAAACGAGA |
TGACTTCGAA |
AAGCTGACTA |
ATTATTCGGT |
GAGGCTATTT |
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1841 |
AAATTCTTTC |
TTTGGTTTCA |
TTGCCGAGGG |
TCTTGCAAAG |
CATTTATTCT |
CCAGAAAGTA |
GACATTAGCT |
ATTTAACAGT |
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1921 |
TGCTAAAGCT |
ATGAACTCAA |
CTCATGGCTG |
AAACTCTACC |
TTACTATTTC |
CATTCGTGTT |
TGGGTGACTT |
TGCAAAGCCA |
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2001 |
GTAAGAGAAT |
CGCTGAAGTA |
TGTAATGTAG |
AGAAATGCTG |
GCATTGTAAC |
TATTGCGTAA |
AGACAGGTGA |
GTTGACAAAT |
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2081 |
CCAGTGAAGA |
GGAAGTAGGT |
GAGGAAGAAG |
CGGGGAGTAC |
TGAGAAGCAG |
TTCTCTCATT |
GTCCCTTGCT |
CATATGATGG |
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2161 |
AAATTCTCTT |
ACTTTGAATG |
AGAGGCTGTC |
TGTCTTAATG |
GAAAGAGCAG |
TGGGAGGAGC |
TGAGAAGATG |
TGTGTTCTCC |
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2241 |
TCCCAACTCA |
GCCACCAAGG |
AACTGTGATG |
AATCACATGG |
CTGGCTGGGG |
CTCAGTTTCC |
TCATCTTAAA |
AGGAAACTGT |
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2321 |
TAGGCTCACT |
GTATAAGTTT |
GATGACCTTC |
TTTGCTCCAA |
AACTCTACAA |
TGCAAAGAAT |
AGAAAATGAG |
AATGAGATAG |
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2401 |
AAGAAAGCTA |
CAGTCTTTGA |
ATAGGTACCA |
GGGACACCCC |
ACTGCAAGTC |
TCTAGCCAAC |
CTATCAGATT |
GTACTGCCCA |
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2481 |
ATTAGAAGCA |
AGAATGGTTG |
CTGTTTGTTT |
GTTTTTAGGG |
AAAAATAGAT |
AGAATTTATA |
CCTTATGAAA |
AGATTGTTCT |
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2561 |
ATCAACTCTC |
TATCAACTTT |
CAGAATATCT |
CAGCTGGAGA |
ACTCCTTAGA |
CTCCTAAGTC |
TTACCTCATG |
AACTTGTATC |
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2641 |
TTTAAGTTAT |
GGCTTCTATA |
AACAGAAAGA |
TAACGTTGAG |
GCATAAAGAC |
AAATCATGTT |
TTTCAAAATG |
TTTTCTAGAA |
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2721 |
GACAAAGGCC |
TCTAGATTCC |
TTTGGGGTTG |
ACTTTGATAT |
AAATGGGCTC |
AAATGAGAGG |
GACCAGGGTC |
TTCAAGCTAG |
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2801 |
CATTTGTGTT |
CTTAGGATAT |
GTGCTCAGCT |
TTCACTATTG |
CTGGGCCTGC |
CTCTCACTCC |
TCTCATGTAA |
GCCCCCAGAA |
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2881 |
ACAGAAAGGA |
GAGACATGGC |
AACAGGTCTC |
CTTTGGTTAT |
AAACTAGACA |
CTCAGCACTT |
GTTTCTAATC |
CAGTGGTGCC |
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2961 |
CCTGGCTTAC |
TGTTCAGTCC |
TGGATAAGTC |
TCTTAGTTTC |
TTGGTGATGA |
TTTGAACATT |
GGAAAGTAAA |
ATCTGTCACT |
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3041 |
TGCAAACACA |
CAGCTTGTCG |
AAAATTTTTT |
CTACTCTGCA |
GGAACTGGGC |
CTTAAAAAAA |
TGAAAAAAAA |
TCTGTGGTTT |
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3121 |
CTTCCTTCTG |
GAAGCTACAA |
ACCTCCTGTT |
TCTTGATGGG |
CAATCTTGAG |
TGAGCTCTAT |
TAATTATTAT |
TCTCTTTGGC |
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3201 |
TCAGTTGCTA |
AGCTATTTTA |
TGCATGTTAT |
GCCCTTTGAC |
AATTAGTCTT |
TAGCTGTAAT |
CCCCCAGCCA |
TCCTCAGAAA |
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3281 |
TGTGGTGAGT |
AGCCATAGTG |
TTCCCAAGAT |
TAGAAAAAAT |
GTAATGGCAG |
AGCCAAGAGG |
AAGGTAAATG |
GTCCACATTT |
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3361 |
TATGAAGCAT |
CATCTAAATG |
GCCCTATTGG |
TTAGAGTGAG |
GAGATGCAAG |
TAGTTCAATT |
TGCTTGCCTA |
GAAGGCAGGG |
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3441 |
TACTGGAAAA |
GTTGTTGCAA |
TTCTTAATTT |
TAAACTTTAT |
ATATCAGTAA |
GCCATATATA |
AATATGATTG |
GGGGTGTTTA |
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3521 |
TTTTAAAATC |
TATTATGGAA |
ATTGAGAGAC |
TGACCTAATC |
TGGGAGAAAT |
TAAAAATTAC |
AGTTTTCACT |
CGTTTTGGAT |
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3601 |
TTGGTGTTTT |
CTAGGGTACC |
TAACCTAGAT |
CAGTGGTTCT |
CAAACTTAGG |
TGGATGTCAG |
AATCACCTGG |
GGAGCTTAGT |
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3681 |
GAATGCACAG |
GGCACAGTCC |
TTCCACTTCA |
TGCACCTGGA |
TCTCTGAGGT |
CTTTGACAGG |
TTTCCGGATT |
AATCTGCTAT |
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3761 |
GCACAACAGT |
GAGAATCATT |
GACCTATAGT |
TACTCATTTG |
ATGCATACAG |
GAAAGACTGA |
AGTATAAAGT |
GATATAATTG |
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3841 |
GTAGATTGAT |
GATAGAGAGG |
TCATAGAAAC |
AGTCTCATCC |
TCCTTTAGAT |
GAGAAAATAG |
AAGTTCAGAG |
AGGTTAAGTA |
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3921 |
GCTGGCTCAA |
GGTCAGAATT |
ATTGCATGCA |
TGAGATTCAA |
ACCCACCTTT |
TTATGCTGAC |
TCCACAACCA |
GGAGTCTTTT |
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4001 |
CACTATATAA |
TTTCAAGAAT |
TCTATAGAAG |
TAGATTTAAA |
GATATGTGAT |
GGACTCCACC |
ACATTATAGC |
ACAACTAGAA |
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4081 |
ATGTAATTGT |
AATTTTTAGC |
TTCAACTGCT |
GAAGAAGTAA |
ATATTGTATA |
TTAAGGTAAT |
ACGGTCCATT |
TTTTAAAGGA |
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4161 |
ATACTTTTAT |
TTTCACTGAC |
CATCATGACA |
TTAGCAGAAT |
ATCCTGATGG |
CTTATATGCC |
TGAAATTAAT |
TTTGCTCTTT |
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4241 |
TCTTTCCCGA |
TAGGTAACTG |
ACTTGAATGT |
CCAACGCAAA |
GCAATACATG |
AACTCATCCA |
AGTGATGGCT |
GAACTGTCGC |
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4321 |
CAGCAGCTAA |
AACAGGGAAG |
CGAAAAAGGA |
GTCAGATGCT |
GTTTCGAGGT |
CGAAGAGCAT |
CCCAGTAATG |
GTTGTCCTGC |
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4401 |
CTGCAATATT |
TGAATTTTAA |
ATCTAAATCT |
ATTTATTAAT |
ATTTAACATT |
ATTTATATGG |
GGAATATATT |
TTTAGACTCA |
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4481 |
TCAATCAAAT |
AAGTATTTAT |
AATAGCAACT |
TTTGTGTAAT |
GAAAATGAAT |
ATCTATTAAT |
ATATGTATTA |
TTTATAATTC |
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4561 |
CTATATCCTG |
TGACTGTCTC |
ACTTAATCCT |
TTGTTTTCTG |
ACTAATTAGG |
CAAGGCTATG |
TGATTACAAG |
GCTTTATCTC |
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4641 |
AGGGGCCAAC |
TAGGCAGCCA |
ACCTAAGCAA |
GATCCCATGG |
GTTGTGTGTT |
TATTTCACTT |
GATGATACAA |
TGAACACTTA |
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4721 |
TAAGTGAAGT |
GATACTATCC |
AGTTACTGCC |
GGTTTGAAAA |
TATGCCTGCA |
ATCTGAGCCA |
GTGCTTTAAT |
GGCATGTCAG |
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4801 |
ACAGAACTTG |
AATGTGTCAG |
GTGACCCTGA |
TGAAAACATA |
GCATCTCAGG |
AGATTTCATG |
CCTGGTGCTT |
CCAAATATTG |
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4881 |
TTGACAACTG |
TGACTGTACC |
CAAATGGAAA |
GTAACTCATT |
TGTTAAAATT |
ATCAATATCT |
AATATATATG |
AATAAAGTGT |
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4961 |
AAGTTCACAA |
CT |
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>ref|Gene_ID:3458|IFNG|NC_000012.11:68548549...68553520 (-)
ACATTGTTCTGATCATCTGAAGATCAGCTATTAGAAGAGAAAGATCAGTTAAGTCCTTTGGACCTGATCAGCTTGATACA
AGAACTACTGATTTCAACTTCTTTGGCTTAATTCTCTCGGAAACGATGAAATATACAAGTTATATCTTGGCTTTTCAGCT
CTGCATCGTTTTGGGTTCTCTTGGCTGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTTG
TAAGTATGACTTTTTAATAGTACTTGTTTGTGGTTGAAAATGACTGAATATCGACTTGCTGTAGCATCTCTGATAGGCTG
TCATCTCTTGTAGGCAGTCATTTTGAGATTTGGTGTTATTTTGTTAATTATTGACTAGATGAGTTCCTTGACTAAATAAT
CTAGATATTGTTTTAACCTTCTGCTCAGTTTGTATAGAGACTTAAAAGGGATTTATGAATTTTCCAAAAGATGGGCATAA
TATGGGTATGAAGCATAATGATGTTAATAATTTTGTGGTGGGAACTCATTCAGTTGTGATAGTCAAGGAGTATGCAGATT
GAAAAAAATGATTGGTTATTAGTTTTTGACTTCTCAGACTCTAAGGTCAAGATTAGCATTAAAAAGGTAATAGGAAATGT
TTACAAATTAAAGTCAAAAAGGTCCTTAAAGCTTTGGCTTAAAAAAATAACTGATAGGTGATTTTCTCCAAAAAGTGATT
TCAACATTCTGCTTCTCTATCTATATTACTTGTGAAGTATTCCGGAACTTCGTTGCTCACTGGGATTTTGGAAGAATTAT
GATTCTGGCTAAGGAATGTTTAAAAATTTTAAGTGAATTTTTTGAGTTTCTTTTAAAATTTTATTGATGGTTAATGAAAA
GTTTTTACATTTTAAATATTTCATTATTTGTTTAAAACTTAGCTGTTATAATTATAGCTGTCATAATAATATTCAGACAT
TCACAATTGATTTTATTCTTACAACACAAAATCAAATCACACACACACACACACACACACACACACTCGCACATGTTTGG
AACTATCTTTTAAAGCTCGTATAATAATACCCTACAGGAAGGCACAGTAGATGTAATAGAAACCTGTACCATTGGGGGGC
AGTATTTTATAGTGGGGTGGCTTTGCTGTTTTTTGTTTTTGTATTTTTTAGCCTAGCTTGAAAATACTTTCTTTAGCTTA
CTATAGTTTTTGGGACCTTTGGAGTATCAGCTTTGTTGAGCTCATTTGTGACATTGCAATTTAATGGTTATATTGGGAAA
TAAAAAAGCTAAAAGAACATAATAGTCTTTGTCTATATCTCACATAAGCCTTTTGGGAATACTTATTGTTAGAACTAAGC
AGAAGAGTTGAAAAGGAAATCAGTGAATATTGTCACATCTGAGTTCAATGAAACTTGAAATATATTTTTAAGGCAATTTA
TGGGCTAATTGTAAACCAATTTTTTCTTTTTTTTTTTTTAGAATGCAGGTCATTCAGATGTAGCGGATAATGGAACTCTT
TTCTTAGGCATTTTGAAGAATTGGAAAGAGGTAAGCTGAATATTCCCATTTGGCTAATTTTCCTGTTGCTTGCTTTCTGA
TGGATAAATTCACATCATCCTCTGTTTGTGCTCTTTCCTTCCAAGGAGAGTGACAGAAAAATAATGCAGAGCCAAATTGT
CTCCTTTTACTTCAAACTTTTTAAAAACTTTAAAGATGACCAGAGCATCCAAAAGAGTGTGGAGACCATCAAGGAAGACA
TGAATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTGACTAATTATTCGGTGAGGCTATTT
AAATTCTTTCTTTGGTTTCATTGCCGAGGGTCTTGCAAAGCATTTATTCTCCAGAAAGTAGACATTAGCTATTTAACAGT
TGCTAAAGCTATGAACTCAACTCATGGCTGAAACTCTACCTTACTATTTCCATTCGTGTTTGGGTGACTTTGCAAAGCCA
GTAAGAGAATCGCTGAAGTATGTAATGTAGAGAAATGCTGGCATTGTAACTATTGCGTAAAGACAGGTGAGTTGACAAAT
CCAGTGAAGAGGAAGTAGGTGAGGAAGAAGCGGGGAGTACTGAGAAGCAGTTCTCTCATTGTCCCTTGCTCATATGATGG
AAATTCTCTTACTTTGAATGAGAGGCTGTCTGTCTTAATGGAAAGAGCAGTGGGAGGAGCTGAGAAGATGTGTGTTCTCC
TCCCAACTCAGCCACCAAGGAACTGTGATGAATCACATGGCTGGCTGGGGCTCAGTTTCCTCATCTTAAAAGGAAACTGT
TAGGCTCACTGTATAAGTTTGATGACCTTCTTTGCTCCAAAACTCTACAATGCAAAGAATAGAAAATGAGAATGAGATAG
AAGAAAGCTACAGTCTTTGAATAGGTACCAGGGACACCCCACTGCAAGTCTCTAGCCAACCTATCAGATTGTACTGCCCA
ATTAGAAGCAAGAATGGTTGCTGTTTGTTTGTTTTTAGGGAAAAATAGATAGAATTTATACCTTATGAAAAGATTGTTCT
ATCAACTCTCTATCAACTTTCAGAATATCTCAGCTGGAGAACTCCTTAGACTCCTAAGTCTTACCTCATGAACTTGTATC
TTTAAGTTATGGCTTCTATAAACAGAAAGATAACGTTGAGGCATAAAGACAAATCATGTTTTTCAAAATGTTTTCTAGAA
GACAAAGGCCTCTAGATTCCTTTGGGGTTGACTTTGATATAAATGGGCTCAAATGAGAGGGACCAGGGTCTTCAAGCTAG
CATTTGTGTTCTTAGGATATGTGCTCAGCTTTCACTATTGCTGGGCCTGCCTCTCACTCCTCTCATGTAAGCCCCCAGAA
ACAGAAAGGAGAGACATGGCAACAGGTCTCCTTTGGTTATAAACTAGACACTCAGCACTTGTTTCTAATCCAGTGGTGCC
CCTGGCTTACTGTTCAGTCCTGGATAAGTCTCTTAGTTTCTTGGTGATGATTTGAACATTGGAAAGTAAAATCTGTCACT
TGCAAACACACAGCTTGTCGAAAATTTTTTCTACTCTGCAGGAACTGGGCCTTAAAAAAATGAAAAAAAATCTGTGGTTT
CTTCCTTCTGGAAGCTACAAACCTCCTGTTTCTTGATGGGCAATCTTGAGTGAGCTCTATTAATTATTATTCTCTTTGGC
TCAGTTGCTAAGCTATTTTATGCATGTTATGCCCTTTGACAATTAGTCTTTAGCTGTAATCCCCCAGCCATCCTCAGAAA
TGTGGTGAGTAGCCATAGTGTTCCCAAGATTAGAAAAAATGTAATGGCAGAGCCAAGAGGAAGGTAAATGGTCCACATTT
TATGAAGCATCATCTAAATGGCCCTATTGGTTAGAGTGAGGAGATGCAAGTAGTTCAATTTGCTTGCCTAGAAGGCAGGG
TACTGGAAAAGTTGTTGCAATTCTTAATTTTAAACTTTATATATCAGTAAGCCATATATAAATATGATTGGGGGTGTTTA
TTTTAAAATCTATTATGGAAATTGAGAGACTGACCTAATCTGGGAGAAATTAAAAATTACAGTTTTCACTCGTTTTGGAT
TTGGTGTTTTCTAGGGTACCTAACCTAGATCAGTGGTTCTCAAACTTAGGTGGATGTCAGAATCACCTGGGGAGCTTAGT
GAATGCACAGGGCACAGTCCTTCCACTTCATGCACCTGGATCTCTGAGGTCTTTGACAGGTTTCCGGATTAATCTGCTAT
GCACAACAGTGAGAATCATTGACCTATAGTTACTCATTTGATGCATACAGGAAAGACTGAAGTATAAAGTGATATAATTG
GTAGATTGATGATAGAGAGGTCATAGAAACAGTCTCATCCTCCTTTAGATGAGAAAATAGAAGTTCAGAGAGGTTAAGTA
GCTGGCTCAAGGTCAGAATTATTGCATGCATGAGATTCAAACCCACCTTTTTATGCTGACTCCACAACCAGGAGTCTTTT
CACTATATAATTTCAAGAATTCTATAGAAGTAGATTTAAAGATATGTGATGGACTCCACCACATTATAGCACAACTAGAA
ATGTAATTGTAATTTTTAGCTTCAACTGCTGAAGAAGTAAATATTGTATATTAAGGTAATACGGTCCATTTTTTAAAGGA
ATACTTTTATTTTCACTGACCATCATGACATTAGCAGAATATCCTGATGGCTTATATGCCTGAAATTAATTTTGCTCTTT
TCTTTCCCGATAGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATGGCTGAACTGTCGC
CAGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCGAGGTCGAAGAGCATCCCAGTAATGGTTGTCCTGC
CTGCAATATTTGAATTTTAAATCTAAATCTATTTATTAATATTTAACATTATTTATATGGGGAATATATTTTTAGACTCA
TCAATCAAATAAGTATTTATAATAGCAACTTTTGTGTAATGAAAATGAATATCTATTAATATATGTATTATTTATAATTC
CTATATCCTGTGACTGTCTCACTTAATCCTTTGTTTTCTGACTAATTAGGCAAGGCTATGTGATTACAAGGCTTTATCTC
AGGGGCCAACTAGGCAGCCAACCTAAGCAAGATCCCATGGGTTGTGTGTTTATTTCACTTGATGATACAATGAACACTTA
TAAGTGAAGTGATACTATCCAGTTACTGCCGGTTTGAAAATATGCCTGCAATCTGAGCCAGTGCTTTAATGGCATGTCAG
ACAGAACTTGAATGTGTCAGGTGACCCTGATGAAAACATAGCATCTCAGGAGATTTCATGCCTGGTGCTTCCAAATATTG
TTGACAACTGTGACTGTACCCAAATGGAAAGTAACTCATTTGTTAAAATTATCAATATCTAATATATATGAATAAAGTGT
AAGTTCACAACT
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Primary source |
RefSeq : NM_000619.2 (GI:56786137)
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Name |
Interferon, gamma (IFNG)
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
1240 nt
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Map |
12q14
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Location |
Chromosome 12 (NC_000012.11) strand : -
68548549...68549266 | 68551692...68551874 | 68551970...68552038 | 68553281...68553520 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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240
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240
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1
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Exon 2
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241
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309
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69
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1
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Exon 3
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310
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492
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183
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1
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Exon 4
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493
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1210
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718
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1
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Primary source |
NCBI : CCDS8980
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Nucleotide |
IFNG, mRNA isoform 1[NM_000619.2] : 127...627
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Length |
501
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Location |
Chromosome 12 (NC_000012.11) strand : -
68549132...68549266 | 68551692...68551874 | 68551970...68552038 | 68553281...68553394 |
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Start codon |
1
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Translation |
NP_000610.2 |
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1 |
CACATTGTTC |
TGATCATCTG |
AAGATCAGCT |
ATTAGAAGAG |
AAAGATCAGT |
TAAGTCCTTT |
GGACCTGATC |
AGCTTGATAC |
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81 |
AAGAACTACT |
GATTTCAACT |
TCTTTGGCTT |
AATTCTCTCG |
GAAACGATGA |
AATATACAAG |
TTATATCTTG |
GCTTTTCAGC |
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161 |
TCTGCATCGT |
TTTGGGTTCT |
CTTGGCTGTT |
ACTGCCAGGA |
CCCATATGTA |
AAAGAAGCAG |
AAAACCTTAA |
GAAATATTTT |
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241 |
AATGCAGGTC |
ATTCAGATGT |
AGCGGATAAT |
GGAACTCTTT |
TCTTAGGCAT |
TTTGAAGAAT |
TGGAAAGAGG |
AGAGTGACAG |
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321 |
AAAAATAATG |
CAGAGCCAAA |
TTGTCTCCTT |
TTACTTCAAA |
CTTTTTAAAA |
ACTTTAAAGA |
TGACCAGAGC |
ATCCAAAAGA |
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401 |
GTGTGGAGAC |
CATCAAGGAA |
GACATGAATG |
TCAAGTTTTT |
CAATAGCAAC |
AAAAAGAAAC |
GAGATGACTT |
CGAAAAGCTG |
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481 |
ACTAATTATT |
CGGTAACTGA |
CTTGAATGTC |
CAACGCAAAG |
CAATACATGA |
ACTCATCCAA |
GTGATGGCTG |
AACTGTCGCC |
|
561 |
AGCAGCTAAA |
ACAGGGAAGC |
GAAAAAGGAG |
TCAGATGCTG |
TTTCGAGGTC |
GAAGAGCATC |
CCAGTAATGG |
TTGTCCTGCC |
|
641 |
TGCAATATTT |
GAATTTTAAA |
TCTAAATCTA |
TTTATTAATA |
TTTAACATTA |
TTTATATGGG |
GAATATATTT |
TTAGACTCAT |
|
721 |
CAATCAAATA |
AGTATTTATA |
ATAGCAACTT |
TTGTGTAATG |
AAAATGAATA |
TCTATTAATA |
TATGTATTAT |
TTATAATTCC |
|
801 |
TATATCCTGT |
GACTGTCTCA |
CTTAATCCTT |
TGTTTTCTGA |
CTAATTAGGC |
AAGGCTATGT |
GATTACAAGG |
CTTTATCTCA |
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881 |
GGGGCCAACT |
AGGCAGCCAA |
CCTAAGCAAG |
ATCCCATGGG |
TTGTGTGTTT |
ATTTCACTTG |
ATGATACAAT |
GAACACTTAT |
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961 |
AAGTGAAGTG |
ATACTATCCA |
GTTACTGCCG |
GTTTGAAAAT |
ATGCCTGCAA |
TCTGAGCCAG |
TGCTTTAATG |
GCATGTCAGA |
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1041 |
CAGAACTTGA |
ATGTGTCAGG |
TGACCCTGAT |
GAAAACATAG |
CATCTCAGGA |
GATTTCATGC |
CTGGTGCTTC |
CAAATATTGT |
|
1121 |
TGACAACTGT |
GACTGTACCC |
AAATGGAAAG |
TAACTCATTT |
GTTAAAATTA |
TCAATATCTA |
ATATATATGA |
ATAAAGTGTA |
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1201 |
AGTTCACAAC |
AAAAAAAAAA |
AAAAAAAAAA |
AAAAAAAAAA |
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>gi|56786137|ref|NM_000619.2|Interferon, gamma (IFNG)
CACATTGTTCTGATCATCTGAAGATCAGCTATTAGAAGAGAAAGATCAGTTAAGTCCTTTGGACCTGATCAGCTTGATAC
AAGAACTACTGATTTCAACTTCTTTGGCTTAATTCTCTCGGAAACGATGAAATATACAAGTTATATCTTGGCTTTTCAGC
TCTGCATCGTTTTGGGTTCTCTTGGCTGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTT
AATGCAGGTCATTCAGATGTAGCGGATAATGGAACTCTTTTCTTAGGCATTTTGAAGAATTGGAAAGAGGAGAGTGACAG
AAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTTAAAAACTTTAAAGATGACCAGAGCATCCAAAAGA
GTGTGGAGACCATCAAGGAAGACATGAATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTG
ACTAATTATTCGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATGGCTGAACTGTCGCC
AGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCGAGGTCGAAGAGCATCCCAGTAATGGTTGTCCTGCC
TGCAATATTTGAATTTTAAATCTAAATCTATTTATTAATATTTAACATTATTTATATGGGGAATATATTTTTAGACTCAT
CAATCAAATAAGTATTTATAATAGCAACTTTTGTGTAATGAAAATGAATATCTATTAATATATGTATTATTTATAATTCC
TATATCCTGTGACTGTCTCACTTAATCCTTTGTTTTCTGACTAATTAGGCAAGGCTATGTGATTACAAGGCTTTATCTCA
GGGGCCAACTAGGCAGCCAACCTAAGCAAGATCCCATGGGTTGTGTGTTTATTTCACTTGATGATACAATGAACACTTAT
AAGTGAAGTGATACTATCCAGTTACTGCCGGTTTGAAAATATGCCTGCAATCTGAGCCAGTGCTTTAATGGCATGTCAGA
CAGAACTTGAATGTGTCAGGTGACCCTGATGAAAACATAGCATCTCAGGAGATTTCATGCCTGGTGCTTCCAAATATTGT
TGACAACTGTGACTGTACCCAAATGGAAAGTAACTCATTTGTTAAAATTATCAATATCTAATATATATGAATAAAGTGTA
AGTTCACAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
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Exon number |
1
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Length |
240 nt
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Location |
Chromosome 12 (NC_000012.11) : 68553281...68553520 (-)
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Is part of |
IFNG, mRNA isoform 1
(NM_000619.2)
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Sequence |
Show
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CACATTGTTCTGATCATCTGAAGATCAGCTATTAGAAGAGAAAGATCAGTTAAGTCCTTTGGACCTGATCAGCTTGATAC
AAGAACTACTGATTTCAACTTCTTTGGCTTAATTCTCTCGGAAACGATGAAATATACAAGTTATATCTTGGCTTTTCAGC
TCTGCATCGTTTTGGGTTCTCTTGGCTGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTT
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Exon number |
3
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Length |
183 nt
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Location |
Chromosome 12 (NC_000012.11) : 68551692...68551874 (-)
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Is part of |
IFNG, mRNA isoform 1
(NM_000619.2)
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Sequence |
Show
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GAGAGTGACAGAAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTTAAAAACTTTAAAGATGACCAGAG
CATCCAAAAGAGTGTGGAGACCATCAAGGAAGACATGAATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACT
TCGAAAAGCTGACTAATTATTCG
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Exon number |
4
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Length |
718 nt
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Location |
Chromosome 12 (NC_000012.11) : 68548549...68549266 (-)
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Is part of |
IFNG, mRNA isoform 1
(NM_000619.2)
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Sequence |
Show
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GTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATGGCTGAACTGTCGCCAGCAGCTAAAAC
AGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCGAGGTCGAAGAGCATCCCAGTAATGGTTGTCCTGCCTGCAATATTTGA
ATTTTAAATCTAAATCTATTTATTAATATTTAACATTATTTATATGGGGAATATATTTTTAGACTCATCAATCAAATAAG
TATTTATAATAGCAACTTTTGTGTAATGAAAATGAATATCTATTAATATATGTATTATTTATAATTCCTATATCCTGTGA
CTGTCTCACTTAATCCTTTGTTTTCTGACTAATTAGGCAAGGCTATGTGATTACAAGGCTTTATCTCAGGGGCCAACTAG
GCAGCCAACCTAAGCAAGATCCCATGGGTTGTGTGTTTATTTCACTTGATGATACAATGAACACTTATAAGTGAAGTGAT
ACTATCCAGTTACTGCCGGTTTGAAAATATGCCTGCAATCTGAGCCAGTGCTTTAATGGCATGTCAGACAGAACTTGAAT
GTGTCAGGTGACCCTGATGAAAACATAGCATCTCAGGAGATTTCATGCCTGGTGCTTCCAAATATTGTTGACAACTGTGA
CTGTACCCAAATGGAAAGTAACTCATTTGTTAAAATTATCAATATCTAATATATATGAATAAAGTGTAAGTTCACAAC
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Primary source |
Uniprot : P01579
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Name |
Interferon gamma
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Alternative name(s) |
Immune interferon
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Synonym(s) |
IFN-gamma
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Organism |
Homo sapiens
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Length |
166 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Disease
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In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
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Function
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Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
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Pharmaceutical
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Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD).
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Ptm
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Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
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Similarity
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Belongs to the type II (or gamma) interferon family.
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Subcellular location
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Secreted.
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Subunit
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Homodimer.
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Tissue specificity
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Released primarily from activated T lymphocytes.
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Biological process
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protein import into nucleus, translocation [GO:0000060]
immune response [GO:0006955]
cell cycle arrest [GO:0007050]
cell surface receptor linked signaling pathway [GO:0007166]
response to virus [GO:0009615]
positive regulation of interleukin-12 production [GO:0032735]
positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]
positive regulation of smooth muscle cell apoptosis [GO:0034393]
regulation of growth [GO:0040008]
tyrosine phosphorylation of Stat1 protein [GO:0042508]
positive regulation of tyrosine phosphorylation of Stat1 protein [GO:0042511]
positive regulation of nitric oxide biosynthetic process [GO:0045429]
negative regulation of smooth muscle cell proliferation [GO:0048662]
regulation of insulin secretion [GO:0050796]
positive regulation of membrane protein ectodomain proteolysis [GO:0051044]
positive regulation of killing of cells of another organism [GO:0051712]
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [GO:0060550]
positive regulation of fructose 1,6-bisphosphate metabolic process [GO:0060552]
positive regulation of vitamin D biosynthetic process [GO:0060557]
positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]
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Cellular component
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extracellular space [GO:0005615]
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Molecular function
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cytokine activity [GO:0005125]
interferon-gamma receptor binding [GO:0005133]
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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Molecule processing |
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Propeptide
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162 - 166
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5
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PRO_0000259481
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Signal
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1 - 23
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23
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P01579-SIGNAL-1
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Natural variations |
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Natural variant site
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29 - 29
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1
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K -> Q
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VAR_004017
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Natural variant site
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160 - 160
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1
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R -> Q
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VAR_004018
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Amino acid modifications |
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Glycosylation
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48 - 48
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1
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N-linked (GlcNAc...)
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P01579-CARBOHYD-48
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Glycosylation
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120 - 120
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1
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N-linked (GlcNAc...); in dimeric form
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P01579-CARBOHYD-120
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Modified residue
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24 - 24
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1
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Pyrrolidone carboxylic acid
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P01579-MOD_RES-24
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1 |
MKYTSYILAF |
QLCIVLGSLG |
CYCQDPYVKE |
AENLKKYFNA |
GHSDVADNGT |
LFLGILKNWK |
EESDRKIMQS |
QIVSFYFKLF |
|
81 |
KNFKDDQSIQ |
KSVETIKEDM |
NVKFFNSNKK |
KRDDFEKLTN |
YSVTDLNVQR |
KAIHELIQVM |
AELSPAAKTG |
KRKRSQMLFR |
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161 |
GRRASQ |
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>sp|P01579|IFNG_human Interferon gamma
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLF
KNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFR
GRRASQ
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