ARSA, mRNA isoform 1 - Generality top
	Primary source RefSeq : NM_000487.4 (GI:146229325) Name Arylsulfatase A (ARSA), transcript variant 1 Type of transcript mRNA Organism Homo sapiens Length 2071 nt Map 22q13.33 Location Chromosome 22 (NC_000022.10)  strand : - 51063448...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066606
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1d 1 624 624 1 Exon 2 625 865 241 1 Exon 3 866 1084 219 1 Exon 4 1085 1254 170 1 Exon 5 1255 1379 125 1 Exon 6 1380 1507 128 1 Exon 7 1508 1610 103 1 Exon 8 1611 2054 444 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source rs71708494 insertion 625 -/largedeletion 13 ? dbSNP
	CDS top
	Primary source NCBI : CCDS14100 Nucleotide ARSA, mRNA isoform 1[NM_000487.4] : 407...1930 Length 1524 Location Chromosome 22 (NC_000022.10)  strand : - 51063572...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066200   Start codon 1 Translation NP_000478.2
	Sequence top
	FASTA 1  AAGGGTCACA GGTCACGGGG CGGGGCCGAG GCGGAAGCGC CCGCAGCCCG GTACCGGCTC CTCCTGGGCT CCCTCTAGCG 81  CCTTCCCCCC GGCCCGACTC CGCTGGTCAG CGCCAAGTGA CTTACGCCCC CGACCCTGAG CCCGGACCGC TAGGCGAGGA 161  GGATCAGATC TCCGCTCGAG AATCTGAAGG TGCCCTGGTC CTGGAGGAGT TCCGTCCCAG CCCGCGGTCT CCCGGTACTG 241  TCGGGCCCCG GCCCTCTGGA GCTTCAGGAG GCGGCCGTCA GGGTCGGGGA GTATTTGGGT CCGGGGTCTC AGGGAAGGGC 321  GGCGCCTGGG TCTGCGGTAT CGGAAAGAGC CTGCTGGAGC CAAGTAGCCC TCCCTCTCTT GGGACAGACC CCTCGGTCCC 401  ATGTCCATGG GGGCACCGCG GTCCCTCCTC CTGGCCCTGG CTGCTGGCCT GGCCGTTGCC CGTCCGCCCA ACATCGTGCT 481  GATCTTTGCC GACGACCTCG GCTATGGGGA CCTGGGCTGC TATGGGCACC CCAGCTCTAC CACTCCCAAC CTGGACCAGC 561  TGGCGGCGGG AGGGCTGCGG TTCACAGACT TCTACGTGCC TGTGTCTCTG TGCACACCCT CTAGGGCCGC CCTCCTGACC 641  GGCCGGCTCC CGGTTCGGAT GGGCATGTAC CCTGGCGTCC TGGTGCCCAG CTCCCGGGGG GGCCTGCCCC TGGAGGAGGT 721  GACCGTGGCC GAAGTCCTGG CTGCCCGAGG CTACCTCACA GGAATGGCCG GCAAGTGGCA CCTTGGGGTG GGGCCTGAGG 801  GGGCCTTCCT GCCCCCCCAT CAGGGCTTCC ATCGATTTCT AGGCATCCCG TACTCCCACG ACCAGGGCCC CTGCCAGAAC 881  CTGACCTGCT TCCCGCCGGC CACTCCTTGC GACGGTGGCT GTGACCAGGG CCTGGTCCCC ATCCCACTGT TGGCCAACCT 961  GTCCGTGGAG GCGCAGCCCC CCTGGCTGCC CGGACTAGAG GCCCGCTACA TGGCTTTCGC CCATGACCTC ATGGCCGACG 1041  CCCAGCGCCA GGATCGCCCC TTCTTCCTGT ACTATGCCTC TCACCACACC CACTACCCTC AGTTCAGTGG GCAGAGCTTT 1121  GCAGAGCGTT CAGGCCGCGG GCCATTTGGG GACTCCCTGA TGGAGCTGGA TGCAGCTGTG GGGACCCTGA TGACAGCCAT 1201  AGGGGACCTG GGGCTGCTTG AAGAGACGCT GGTCATCTTC ACTGCAGACA ATGGACCTGA GACCATGCGT ATGTCCCGAG 1281  GCGGCTGCTC CGGTCTCTTG CGGTGTGGAA AGGGAACGAC CTACGAGGGC GGTGTCCGAG AGCCTGCCTT GGCCTTCTGG 1361  CCAGGTCATA TCGCTCCCGG CGTGACCCAC GAGCTGGCCA GCTCCCTGGA CCTGCTGCCT ACCCTGGCAG CCCTGGCTGG 1441  GGCCCCACTG CCCAATGTCA CCTTGGATGG CTTTGACCTC AGCCCCCTGC TGCTGGGCAC AGGCAAGAGC CCTCGGCAGT 1521  CTCTCTTCTT CTACCCGTCC TACCCAGACG AGGTCCGTGG GGTTTTTGCT GTGCGGACTG GAAAGTACAA GGCTCACTTC 1601  TTCACCCAGG GCTCTGCCCA CAGTGATACC ACTGCAGACC CTGCCTGCCA CGCCTCCAGC TCTCTGACTG CTCATGAGCC 1681  CCCGCTGCTC TATGACCTGT CCAAGGACCC TGGTGAGAAC TACAACCTGC TGGGGGGTGT GGCCGGGGCC ACCCCAGAGG 1761  TGCTGCAAGC CCTGAAACAG CTTCAGCTGC TCAAGGCCCA GTTAGACGCA GCTGTGACCT TCGGCCCCAG CCAGGTGGCC 1841  CGGGGCGAGG ACCCCGCCCT GCAGATCTGC TGTCATCCTG GCTGCACCCC CCGCCCAGCT TGCTGCCATT GCCCAGATCC 1921  CCATGCCTGA GGGCCCCTCG GCTGGCCTGG GCATGTGATG GCTCCTCACT GGGAGCCTGT GGGGGAGGCT CAGGTGTCTG 2001  GAGGGGGTTT GTGCCTGATA ACGTAATAAC ACCAGTGGAG ACTTGCAGAT GTGAAAAAAA AAAAAAAAAA A >gi|146229325|ref|NM_000487.4|Arylsulfatase A (ARSA), transcript variant 1 AAGGGTCACAGGTCACGGGGCGGGGCCGAGGCGGAAGCGCCCGCAGCCCGGTACCGGCTCCTCCTGGGCTCCCTCTAGCG CCTTCCCCCCGGCCCGACTCCGCTGGTCAGCGCCAAGTGACTTACGCCCCCGACCCTGAGCCCGGACCGCTAGGCGAGGA GGATCAGATCTCCGCTCGAGAATCTGAAGGTGCCCTGGTCCTGGAGGAGTTCCGTCCCAGCCCGCGGTCTCCCGGTACTG TCGGGCCCCGGCCCTCTGGAGCTTCAGGAGGCGGCCGTCAGGGTCGGGGAGTATTTGGGTCCGGGGTCTCAGGGAAGGGC GGCGCCTGGGTCTGCGGTATCGGAAAGAGCCTGCTGGAGCCAAGTAGCCCTCCCTCTCTTGGGACAGACCCCTCGGTCCC ATGTCCATGGGGGCACCGCGGTCCCTCCTCCTGGCCCTGGCTGCTGGCCTGGCCGTTGCCCGTCCGCCCAACATCGTGCT GATCTTTGCCGACGACCTCGGCTATGGGGACCTGGGCTGCTATGGGCACCCCAGCTCTACCACTCCCAACCTGGACCAGC TGGCGGCGGGAGGGCTGCGGTTCACAGACTTCTACGTGCCTGTGTCTCTGTGCACACCCTCTAGGGCCGCCCTCCTGACC GGCCGGCTCCCGGTTCGGATGGGCATGTACCCTGGCGTCCTGGTGCCCAGCTCCCGGGGGGGCCTGCCCCTGGAGGAGGT GACCGTGGCCGAAGTCCTGGCTGCCCGAGGCTACCTCACAGGAATGGCCGGCAAGTGGCACCTTGGGGTGGGGCCTGAGG GGGCCTTCCTGCCCCCCCATCAGGGCTTCCATCGATTTCTAGGCATCCCGTACTCCCACGACCAGGGCCCCTGCCAGAAC CTGACCTGCTTCCCGCCGGCCACTCCTTGCGACGGTGGCTGTGACCAGGGCCTGGTCCCCATCCCACTGTTGGCCAACCT GTCCGTGGAGGCGCAGCCCCCCTGGCTGCCCGGACTAGAGGCCCGCTACATGGCTTTCGCCCATGACCTCATGGCCGACG CCCAGCGCCAGGATCGCCCCTTCTTCCTGTACTATGCCTCTCACCACACCCACTACCCTCAGTTCAGTGGGCAGAGCTTT GCAGAGCGTTCAGGCCGCGGGCCATTTGGGGACTCCCTGATGGAGCTGGATGCAGCTGTGGGGACCCTGATGACAGCCAT AGGGGACCTGGGGCTGCTTGAAGAGACGCTGGTCATCTTCACTGCAGACAATGGACCTGAGACCATGCGTATGTCCCGAG GCGGCTGCTCCGGTCTCTTGCGGTGTGGAAAGGGAACGACCTACGAGGGCGGTGTCCGAGAGCCTGCCTTGGCCTTCTGG CCAGGTCATATCGCTCCCGGCGTGACCCACGAGCTGGCCAGCTCCCTGGACCTGCTGCCTACCCTGGCAGCCCTGGCTGG GGCCCCACTGCCCAATGTCACCTTGGATGGCTTTGACCTCAGCCCCCTGCTGCTGGGCACAGGCAAGAGCCCTCGGCAGT CTCTCTTCTTCTACCCGTCCTACCCAGACGAGGTCCGTGGGGTTTTTGCTGTGCGGACTGGAAAGTACAAGGCTCACTTC TTCACCCAGGGCTCTGCCCACAGTGATACCACTGCAGACCCTGCCTGCCACGCCTCCAGCTCTCTGACTGCTCATGAGCC CCCGCTGCTCTATGACCTGTCCAAGGACCCTGGTGAGAACTACAACCTGCTGGGGGGTGTGGCCGGGGCCACCCCAGAGG TGCTGCAAGCCCTGAAACAGCTTCAGCTGCTCAAGGCCCAGTTAGACGCAGCTGTGACCTTCGGCCCCAGCCAGGTGGCC CGGGGCGAGGACCCCGCCCTGCAGATCTGCTGTCATCCTGGCTGCACCCCCCGCCCAGCTTGCTGCCATTGCCCAGATCC CCATGCCTGAGGGCCCCTCGGCTGGCCTGGGCATGTGATGGCTCCTCACTGGGAGCCTGTGGGGGAGGCTCAGGTGTCTG GAGGGGGTTTGTGCCTGATAACGTAATAACACCAGTGGAGACTTGCAGATGTGAAAAAAAAAAAAAAAAAA

	ARSA, mRNA isoform 2 - Generality top
	Primary source RefSeq : NM_001085425.1 (GI:146229323) Name Arylsulfatase A (ARSA), transcript variant 2 Type of transcript mRNA Organism Homo sapiens Length 1966 nt Map 22q13.33 Location Chromosome 22 (NC_000022.10)  strand : - 51063448...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066219   51066325...51066606
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1c 1 282 282 1 Exon 1e 283 519 237 1 Exon 2 520 760 241 1 Exon 3 761 979 219 1 Exon 4 980 1149 170 1 Exon 5 1150 1274 125 1 Exon 6 1275 1402 128 1 Exon 7 1403 1505 103 1 Exon 8 1506 1949 444 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source rs6151406 SNP 56 c/g 1 ? dbSNP rs1051539 SNP 100 c/g 1 ? dbSNP rs6151407 SNP 242 c/t 1 ? dbSNP rs6151408 SNP 265 c/g 1 ? dbSNP rs6151410 SNP 538 c/t 1 ? dbSNP rs6151411 SNP 546 c/t 1 ? dbSNP rs60504011 SNP 707 c/g 1 ? dbSNP rs6151412 SNP 754 c/t 1 ? dbSNP rs6151415 SNP 880 g/t 1 ? dbSNP rs34457249 SNP 886 c/t 1 ? dbSNP rs62001867 SNP 914 c/t 1 ? dbSNP rs28940894 SNP 1157 a/c 1 ? dbSNP rs2071421 SNP 1350 a/g 1 ? dbSNP rs6151422 SNP 1367 g/t 1 ? dbSNP rs6151425 SNP 1444 c/t 1 ? dbSNP rs743616 SNP 1473 c/g 1 ? dbSNP rs28940895 SNP 1524 c/t 1 ? dbSNP rs28940893 SNP 1578 c/t 1 ? dbSNP rs6151427 SNP 1620 a/g 1 ? dbSNP rs6151428 SNP 1788 a/g 1 ? dbSNP rs6151429 SNP 1921 a/g 1 ? dbSNP
	CDS top
	Primary source NCBI : CCDS14100 Nucleotide ARSA, mRNA isoform 2[NM_001085425.1] : 302...1825 Length 1524 Location Chromosome 22 (NC_000022.10)  strand : - 51063572...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066200   Start codon 1 Translation NP_001078894.1
	Sequence top
	FASTA 1  AAGGGTCACA GGTCACGGGG CGGGGCCGAG GCGGAAGCGC CCGCAGCCCG GTACCGGCTC CTCCTGGGCT CCCTCTAGCG 81  CCTTCCCCCC GGCCCGACTC CGCTGGTCAG CGCCAAGTGA CTTACGCCCC CGACCCTGAG CCCGGACCGC TAGGCGAGGA 161  GGATCAGATC TCCGCTCGAG AATCTGAAGG TGCCCTGGTC CTGGAGGAGT TCCGTCCCAG CCCGCGGTCT CCCGGTACTG 241  TCGGGCCCCG GCCCTCTGGA GCTTCAGGAG GCGGCCGTCA GGACCCCTCG GTCCCATGTC CATGGGGGCA CCGCGGTCCC 321  TCCTCCTGGC CCTGGCTGCT GGCCTGGCCG TTGCCCGTCC GCCCAACATC GTGCTGATCT TTGCCGACGA CCTCGGCTAT 401  GGGGACCTGG GCTGCTATGG GCACCCCAGC TCTACCACTC CCAACCTGGA CCAGCTGGCG GCGGGAGGGC TGCGGTTCAC 481  AGACTTCTAC GTGCCTGTGT CTCTGTGCAC ACCCTCTAGG GCCGCCCTCC TGACCGGCCG GCTCCCGGTT CGGATGGGCA 561  TGTACCCTGG CGTCCTGGTG CCCAGCTCCC GGGGGGGCCT GCCCCTGGAG GAGGTGACCG TGGCCGAAGT CCTGGCTGCC 641  CGAGGCTACC TCACAGGAAT GGCCGGCAAG TGGCACCTTG GGGTGGGGCC TGAGGGGGCC TTCCTGCCCC CCCATCAGGG 721  CTTCCATCGA TTTCTAGGCA TCCCGTACTC CCACGACCAG GGCCCCTGCC AGAACCTGAC CTGCTTCCCG CCGGCCACTC 801  CTTGCGACGG TGGCTGTGAC CAGGGCCTGG TCCCCATCCC ACTGTTGGCC AACCTGTCCG TGGAGGCGCA GCCCCCCTGG 881  CTGCCCGGAC TAGAGGCCCG CTACATGGCT TTCGCCCATG ACCTCATGGC CGACGCCCAG CGCCAGGATC GCCCCTTCTT 961  CCTGTACTAT GCCTCTCACC ACACCCACTA CCCTCAGTTC AGTGGGCAGA GCTTTGCAGA GCGTTCAGGC CGCGGGCCAT 1041  TTGGGGACTC CCTGATGGAG CTGGATGCAG CTGTGGGGAC CCTGATGACA GCCATAGGGG ACCTGGGGCT GCTTGAAGAG 1121  ACGCTGGTCA TCTTCACTGC AGACAATGGA CCTGAGACCA TGCGTATGTC CCGAGGCGGC TGCTCCGGTC TCTTGCGGTG 1201  TGGAAAGGGA ACGACCTACG AGGGCGGTGT CCGAGAGCCT GCCTTGGCCT TCTGGCCAGG TCATATCGCT CCCGGCGTGA 1281  CCCACGAGCT GGCCAGCTCC CTGGACCTGC TGCCTACCCT GGCAGCCCTG GCTGGGGCCC CACTGCCCAA TGTCACCTTG 1361  GATGGCTTTG ACCTCAGCCC CCTGCTGCTG GGCACAGGCA AGAGCCCTCG GCAGTCTCTC TTCTTCTACC CGTCCTACCC 1441  AGACGAGGTC CGTGGGGTTT TTGCTGTGCG GACTGGAAAG TACAAGGCTC ACTTCTTCAC CCAGGGCTCT GCCCACAGTG 1521  ATACCACTGC AGACCCTGCC TGCCACGCCT CCAGCTCTCT GACTGCTCAT GAGCCCCCGC TGCTCTATGA CCTGTCCAAG 1601  GACCCTGGTG AGAACTACAA CCTGCTGGGG GGTGTGGCCG GGGCCACCCC AGAGGTGCTG CAAGCCCTGA AACAGCTTCA 1681  GCTGCTCAAG GCCCAGTTAG ACGCAGCTGT GACCTTCGGC CCCAGCCAGG TGGCCCGGGG CGAGGACCCC GCCCTGCAGA 1761  TCTGCTGTCA TCCTGGCTGC ACCCCCCGCC CAGCTTGCTG CCATTGCCCA GATCCCCATG CCTGAGGGCC CCTCGGCTGG 1841  CCTGGGCATG TGATGGCTCC TCACTGGGAG CCTGTGGGGG AGGCTCAGGT GTCTGGAGGG GGTTTGTGCC TGATAACGTA 1921  ATAACACCAG TGGAGACTTG CAGATGTGAA AAAAAAAAAA AAAAAA >gi|146229323|ref|NM_001085425.1|Arylsulfatase A (ARSA), transcript variant 2 AAGGGTCACAGGTCACGGGGCGGGGCCGAGGCGGAAGCGCCCGCAGCCCGGTACCGGCTCCTCCTGGGCTCCCTCTAGCG CCTTCCCCCCGGCCCGACTCCGCTGGTCAGCGCCAAGTGACTTACGCCCCCGACCCTGAGCCCGGACCGCTAGGCGAGGA GGATCAGATCTCCGCTCGAGAATCTGAAGGTGCCCTGGTCCTGGAGGAGTTCCGTCCCAGCCCGCGGTCTCCCGGTACTG TCGGGCCCCGGCCCTCTGGAGCTTCAGGAGGCGGCCGTCAGGACCCCTCGGTCCCATGTCCATGGGGGCACCGCGGTCCC TCCTCCTGGCCCTGGCTGCTGGCCTGGCCGTTGCCCGTCCGCCCAACATCGTGCTGATCTTTGCCGACGACCTCGGCTAT GGGGACCTGGGCTGCTATGGGCACCCCAGCTCTACCACTCCCAACCTGGACCAGCTGGCGGCGGGAGGGCTGCGGTTCAC AGACTTCTACGTGCCTGTGTCTCTGTGCACACCCTCTAGGGCCGCCCTCCTGACCGGCCGGCTCCCGGTTCGGATGGGCA TGTACCCTGGCGTCCTGGTGCCCAGCTCCCGGGGGGGCCTGCCCCTGGAGGAGGTGACCGTGGCCGAAGTCCTGGCTGCC CGAGGCTACCTCACAGGAATGGCCGGCAAGTGGCACCTTGGGGTGGGGCCTGAGGGGGCCTTCCTGCCCCCCCATCAGGG CTTCCATCGATTTCTAGGCATCCCGTACTCCCACGACCAGGGCCCCTGCCAGAACCTGACCTGCTTCCCGCCGGCCACTC CTTGCGACGGTGGCTGTGACCAGGGCCTGGTCCCCATCCCACTGTTGGCCAACCTGTCCGTGGAGGCGCAGCCCCCCTGG CTGCCCGGACTAGAGGCCCGCTACATGGCTTTCGCCCATGACCTCATGGCCGACGCCCAGCGCCAGGATCGCCCCTTCTT CCTGTACTATGCCTCTCACCACACCCACTACCCTCAGTTCAGTGGGCAGAGCTTTGCAGAGCGTTCAGGCCGCGGGCCAT TTGGGGACTCCCTGATGGAGCTGGATGCAGCTGTGGGGACCCTGATGACAGCCATAGGGGACCTGGGGCTGCTTGAAGAG ACGCTGGTCATCTTCACTGCAGACAATGGACCTGAGACCATGCGTATGTCCCGAGGCGGCTGCTCCGGTCTCTTGCGGTG TGGAAAGGGAACGACCTACGAGGGCGGTGTCCGAGAGCCTGCCTTGGCCTTCTGGCCAGGTCATATCGCTCCCGGCGTGA CCCACGAGCTGGCCAGCTCCCTGGACCTGCTGCCTACCCTGGCAGCCCTGGCTGGGGCCCCACTGCCCAATGTCACCTTG GATGGCTTTGACCTCAGCCCCCTGCTGCTGGGCACAGGCAAGAGCCCTCGGCAGTCTCTCTTCTTCTACCCGTCCTACCC AGACGAGGTCCGTGGGGTTTTTGCTGTGCGGACTGGAAAGTACAAGGCTCACTTCTTCACCCAGGGCTCTGCCCACAGTG ATACCACTGCAGACCCTGCCTGCCACGCCTCCAGCTCTCTGACTGCTCATGAGCCCCCGCTGCTCTATGACCTGTCCAAG GACCCTGGTGAGAACTACAACCTGCTGGGGGGTGTGGCCGGGGCCACCCCAGAGGTGCTGCAAGCCCTGAAACAGCTTCA GCTGCTCAAGGCCCAGTTAGACGCAGCTGTGACCTTCGGCCCCAGCCAGGTGGCCCGGGGCGAGGACCCCGCCCTGCAGA TCTGCTGTCATCCTGGCTGCACCCCCCGCCCAGCTTGCTGCCATTGCCCAGATCCCCATGCCTGAGGGCCCCTCGGCTGG CCTGGGCATGTGATGGCTCCTCACTGGGAGCCTGTGGGGGAGGCTCAGGTGTCTGGAGGGGGTTTGTGCCTGATAACGTA ATAACACCAGTGGAGACTTGCAGATGTGAAAAAAAAAAAAAAAAAA

	ARSA, mRNA isoform 3 - Generality top
	Primary source RefSeq : NM_001085426.1 (GI:146229328) Name Arylsulfatase A (ARSA), transcript variant 3 Type of transcript mRNA Organism Homo sapiens Length 1918 nt Map 22q13.33 Location Chromosome 22 (NC_000022.10)  strand : - 51063448...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066219   51066373...51066606
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1b 1 234 234 1 Exon 1e 235 471 237 1 Exon 2 472 712 241 1 Exon 3 713 931 219 1 Exon 4 932 1101 170 1 Exon 5 1102 1226 125 1 Exon 6 1227 1354 128 1 Exon 7 1355 1457 103 1 Exon 8 1458 1901 444 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS14100 Nucleotide ARSA, mRNA isoform 3[NM_001085426.1] : 254...1777 Length 1524 Location Chromosome 22 (NC_000022.10)  strand : - 51063572...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066200   Start codon 1 Translation NP_001078895.1
	Sequence top
	FASTA 1  AAGGGTCACA GGTCACGGGG CGGGGCCGAG GCGGAAGCGC CCGCAGCCCG GTACCGGCTC CTCCTGGGCT CCCTCTAGCG 81  CCTTCCCCCC GGCCCGACTC CGCTGGTCAG CGCCAAGTGA CTTACGCCCC CGACCCTGAG CCCGGACCGC TAGGCGAGGA 161  GGATCAGATC TCCGCTCGAG AATCTGAAGG TGCCCTGGTC CTGGAGGAGT TCCGTCCCAG CCCGCGGTCT CCCGACCCCT 241  CGGTCCCATG TCCATGGGGG CACCGCGGTC CCTCCTCCTG GCCCTGGCTG CTGGCCTGGC CGTTGCCCGT CCGCCCAACA 321  TCGTGCTGAT CTTTGCCGAC GACCTCGGCT ATGGGGACCT GGGCTGCTAT GGGCACCCCA GCTCTACCAC TCCCAACCTG 401  GACCAGCTGG CGGCGGGAGG GCTGCGGTTC ACAGACTTCT ACGTGCCTGT GTCTCTGTGC ACACCCTCTA GGGCCGCCCT 481  CCTGACCGGC CGGCTCCCGG TTCGGATGGG CATGTACCCT GGCGTCCTGG TGCCCAGCTC CCGGGGGGGC CTGCCCCTGG 561  AGGAGGTGAC CGTGGCCGAA GTCCTGGCTG CCCGAGGCTA CCTCACAGGA ATGGCCGGCA AGTGGCACCT TGGGGTGGGG 641  CCTGAGGGGG CCTTCCTGCC CCCCCATCAG GGCTTCCATC GATTTCTAGG CATCCCGTAC TCCCACGACC AGGGCCCCTG 721  CCAGAACCTG ACCTGCTTCC CGCCGGCCAC TCCTTGCGAC GGTGGCTGTG ACCAGGGCCT GGTCCCCATC CCACTGTTGG 801  CCAACCTGTC CGTGGAGGCG CAGCCCCCCT GGCTGCCCGG ACTAGAGGCC CGCTACATGG CTTTCGCCCA TGACCTCATG 881  GCCGACGCCC AGCGCCAGGA TCGCCCCTTC TTCCTGTACT ATGCCTCTCA CCACACCCAC TACCCTCAGT TCAGTGGGCA 961  GAGCTTTGCA GAGCGTTCAG GCCGCGGGCC ATTTGGGGAC TCCCTGATGG AGCTGGATGC AGCTGTGGGG ACCCTGATGA 1041  CAGCCATAGG GGACCTGGGG CTGCTTGAAG AGACGCTGGT CATCTTCACT GCAGACAATG GACCTGAGAC CATGCGTATG 1121  TCCCGAGGCG GCTGCTCCGG TCTCTTGCGG TGTGGAAAGG GAACGACCTA CGAGGGCGGT GTCCGAGAGC CTGCCTTGGC 1201  CTTCTGGCCA GGTCATATCG CTCCCGGCGT GACCCACGAG CTGGCCAGCT CCCTGGACCT GCTGCCTACC CTGGCAGCCC 1281  TGGCTGGGGC CCCACTGCCC AATGTCACCT TGGATGGCTT TGACCTCAGC CCCCTGCTGC TGGGCACAGG CAAGAGCCCT 1361  CGGCAGTCTC TCTTCTTCTA CCCGTCCTAC CCAGACGAGG TCCGTGGGGT TTTTGCTGTG CGGACTGGAA AGTACAAGGC 1441  TCACTTCTTC ACCCAGGGCT CTGCCCACAG TGATACCACT GCAGACCCTG CCTGCCACGC CTCCAGCTCT CTGACTGCTC 1521  ATGAGCCCCC GCTGCTCTAT GACCTGTCCA AGGACCCTGG TGAGAACTAC AACCTGCTGG GGGGTGTGGC CGGGGCCACC 1601  CCAGAGGTGC TGCAAGCCCT GAAACAGCTT CAGCTGCTCA AGGCCCAGTT AGACGCAGCT GTGACCTTCG GCCCCAGCCA 1681  GGTGGCCCGG GGCGAGGACC CCGCCCTGCA GATCTGCTGT CATCCTGGCT GCACCCCCCG CCCAGCTTGC TGCCATTGCC 1761  CAGATCCCCA TGCCTGAGGG CCCCTCGGCT GGCCTGGGCA TGTGATGGCT CCTCACTGGG AGCCTGTGGG GGAGGCTCAG 1841  GTGTCTGGAG GGGGTTTGTG CCTGATAACG TAATAACACC AGTGGAGACT TGCAGATGTG AAAAAAAAAA AAAAAAAA >gi|146229328|ref|NM_001085426.1|Arylsulfatase A (ARSA), transcript variant 3 AAGGGTCACAGGTCACGGGGCGGGGCCGAGGCGGAAGCGCCCGCAGCCCGGTACCGGCTCCTCCTGGGCTCCCTCTAGCG CCTTCCCCCCGGCCCGACTCCGCTGGTCAGCGCCAAGTGACTTACGCCCCCGACCCTGAGCCCGGACCGCTAGGCGAGGA GGATCAGATCTCCGCTCGAGAATCTGAAGGTGCCCTGGTCCTGGAGGAGTTCCGTCCCAGCCCGCGGTCTCCCGACCCCT CGGTCCCATGTCCATGGGGGCACCGCGGTCCCTCCTCCTGGCCCTGGCTGCTGGCCTGGCCGTTGCCCGTCCGCCCAACA TCGTGCTGATCTTTGCCGACGACCTCGGCTATGGGGACCTGGGCTGCTATGGGCACCCCAGCTCTACCACTCCCAACCTG GACCAGCTGGCGGCGGGAGGGCTGCGGTTCACAGACTTCTACGTGCCTGTGTCTCTGTGCACACCCTCTAGGGCCGCCCT CCTGACCGGCCGGCTCCCGGTTCGGATGGGCATGTACCCTGGCGTCCTGGTGCCCAGCTCCCGGGGGGGCCTGCCCCTGG AGGAGGTGACCGTGGCCGAAGTCCTGGCTGCCCGAGGCTACCTCACAGGAATGGCCGGCAAGTGGCACCTTGGGGTGGGG CCTGAGGGGGCCTTCCTGCCCCCCCATCAGGGCTTCCATCGATTTCTAGGCATCCCGTACTCCCACGACCAGGGCCCCTG CCAGAACCTGACCTGCTTCCCGCCGGCCACTCCTTGCGACGGTGGCTGTGACCAGGGCCTGGTCCCCATCCCACTGTTGG CCAACCTGTCCGTGGAGGCGCAGCCCCCCTGGCTGCCCGGACTAGAGGCCCGCTACATGGCTTTCGCCCATGACCTCATG GCCGACGCCCAGCGCCAGGATCGCCCCTTCTTCCTGTACTATGCCTCTCACCACACCCACTACCCTCAGTTCAGTGGGCA GAGCTTTGCAGAGCGTTCAGGCCGCGGGCCATTTGGGGACTCCCTGATGGAGCTGGATGCAGCTGTGGGGACCCTGATGA CAGCCATAGGGGACCTGGGGCTGCTTGAAGAGACGCTGGTCATCTTCACTGCAGACAATGGACCTGAGACCATGCGTATG TCCCGAGGCGGCTGCTCCGGTCTCTTGCGGTGTGGAAAGGGAACGACCTACGAGGGCGGTGTCCGAGAGCCTGCCTTGGC CTTCTGGCCAGGTCATATCGCTCCCGGCGTGACCCACGAGCTGGCCAGCTCCCTGGACCTGCTGCCTACCCTGGCAGCCC TGGCTGGGGCCCCACTGCCCAATGTCACCTTGGATGGCTTTGACCTCAGCCCCCTGCTGCTGGGCACAGGCAAGAGCCCT CGGCAGTCTCTCTTCTTCTACCCGTCCTACCCAGACGAGGTCCGTGGGGTTTTTGCTGTGCGGACTGGAAAGTACAAGGC TCACTTCTTCACCCAGGGCTCTGCCCACAGTGATACCACTGCAGACCCTGCCTGCCACGCCTCCAGCTCTCTGACTGCTC ATGAGCCCCCGCTGCTCTATGACCTGTCCAAGGACCCTGGTGAGAACTACAACCTGCTGGGGGGTGTGGCCGGGGCCACC CCAGAGGTGCTGCAAGCCCTGAAACAGCTTCAGCTGCTCAAGGCCCAGTTAGACGCAGCTGTGACCTTCGGCCCCAGCCA GGTGGCCCGGGGCGAGGACCCCGCCCTGCAGATCTGCTGTCATCCTGGCTGCACCCCCCGCCCAGCTTGCTGCCATTGCC CAGATCCCCATGCCTGAGGGCCCCTCGGCTGGCCTGGGCATGTGATGGCTCCTCACTGGGAGCCTGTGGGGGAGGCTCAG GTGTCTGGAGGGGGTTTGTGCCTGATAACGTAATAACACCAGTGGAGACTTGCAGATGTGAAAAAAAAAAAAAAAAAA

	ARSA, mRNA isoform 4 - Generality top
	Primary source RefSeq : NM_001085427.1 (GI:146229330) Name Arylsulfatase A (ARSA), transcript variant 4 Type of transcript mRNA Organism Homo sapiens Length 1873 nt Map 22q13.33 Location Chromosome 22 (NC_000022.10)  strand : - 51063448...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066219   51066418...51066606
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1a 1 189 189 1 Exon 1e 190 426 237 1 Exon 2 427 667 241 1 Exon 3 668 886 219 1 Exon 4 887 1056 170 1 Exon 5 1057 1181 125 1 Exon 6 1182 1309 128 1 Exon 7 1310 1412 103 1 Exon 8 1413 1856 444 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS14100 Nucleotide ARSA, mRNA isoform 4[NM_001085427.1] : 209...1732 Length 1524 Location Chromosome 22 (NC_000022.10)  strand : - 51063572...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51065983...51066200   Start codon 1 Translation NP_001078896.1
	Sequence top
	FASTA 1  AAGGGTCACA GGTCACGGGG CGGGGCCGAG GCGGAAGCGC CCGCAGCCCG GTACCGGCTC CTCCTGGGCT CCCTCTAGCG 81  CCTTCCCCCC GGCCCGACTC CGCTGGTCAG CGCCAAGTGA CTTACGCCCC CGACCCTGAG CCCGGACCGC TAGGCGAGGA 161  GGATCAGATC TCCGCTCGAG AATCTGAAGA CCCCTCGGTC CCATGTCCAT GGGGGCACCG CGGTCCCTCC TCCTGGCCCT 241  GGCTGCTGGC CTGGCCGTTG CCCGTCCGCC CAACATCGTG CTGATCTTTG CCGACGACCT CGGCTATGGG GACCTGGGCT 321  GCTATGGGCA CCCCAGCTCT ACCACTCCCA ACCTGGACCA GCTGGCGGCG GGAGGGCTGC GGTTCACAGA CTTCTACGTG 401  CCTGTGTCTC TGTGCACACC CTCTAGGGCC GCCCTCCTGA CCGGCCGGCT CCCGGTTCGG ATGGGCATGT ACCCTGGCGT 481  CCTGGTGCCC AGCTCCCGGG GGGGCCTGCC CCTGGAGGAG GTGACCGTGG CCGAAGTCCT GGCTGCCCGA GGCTACCTCA 561  CAGGAATGGC CGGCAAGTGG CACCTTGGGG TGGGGCCTGA GGGGGCCTTC CTGCCCCCCC ATCAGGGCTT CCATCGATTT 641  CTAGGCATCC CGTACTCCCA CGACCAGGGC CCCTGCCAGA ACCTGACCTG CTTCCCGCCG GCCACTCCTT GCGACGGTGG 721  CTGTGACCAG GGCCTGGTCC CCATCCCACT GTTGGCCAAC CTGTCCGTGG AGGCGCAGCC CCCCTGGCTG CCCGGACTAG 801  AGGCCCGCTA CATGGCTTTC GCCCATGACC TCATGGCCGA CGCCCAGCGC CAGGATCGCC CCTTCTTCCT GTACTATGCC 881  TCTCACCACA CCCACTACCC TCAGTTCAGT GGGCAGAGCT TTGCAGAGCG TTCAGGCCGC GGGCCATTTG GGGACTCCCT 961  GATGGAGCTG GATGCAGCTG TGGGGACCCT GATGACAGCC ATAGGGGACC TGGGGCTGCT TGAAGAGACG CTGGTCATCT 1041  TCACTGCAGA CAATGGACCT GAGACCATGC GTATGTCCCG AGGCGGCTGC TCCGGTCTCT TGCGGTGTGG AAAGGGAACG 1121  ACCTACGAGG GCGGTGTCCG AGAGCCTGCC TTGGCCTTCT GGCCAGGTCA TATCGCTCCC GGCGTGACCC ACGAGCTGGC 1201  CAGCTCCCTG GACCTGCTGC CTACCCTGGC AGCCCTGGCT GGGGCCCCAC TGCCCAATGT CACCTTGGAT GGCTTTGACC 1281  TCAGCCCCCT GCTGCTGGGC ACAGGCAAGA GCCCTCGGCA GTCTCTCTTC TTCTACCCGT CCTACCCAGA CGAGGTCCGT 1361  GGGGTTTTTG CTGTGCGGAC TGGAAAGTAC AAGGCTCACT TCTTCACCCA GGGCTCTGCC CACAGTGATA CCACTGCAGA 1441  CCCTGCCTGC CACGCCTCCA GCTCTCTGAC TGCTCATGAG CCCCCGCTGC TCTATGACCT GTCCAAGGAC CCTGGTGAGA 1521  ACTACAACCT GCTGGGGGGT GTGGCCGGGG CCACCCCAGA GGTGCTGCAA GCCCTGAAAC AGCTTCAGCT GCTCAAGGCC 1601  CAGTTAGACG CAGCTGTGAC CTTCGGCCCC AGCCAGGTGG CCCGGGGCGA GGACCCCGCC CTGCAGATCT GCTGTCATCC 1681  TGGCTGCACC CCCCGCCCAG CTTGCTGCCA TTGCCCAGAT CCCCATGCCT GAGGGCCCCT CGGCTGGCCT GGGCATGTGA 1761  TGGCTCCTCA CTGGGAGCCT GTGGGGGAGG CTCAGGTGTC TGGAGGGGGT TTGTGCCTGA TAACGTAATA ACACCAGTGG 1841  AGACTTGCAG ATGTGAAAAA AAAAAAAAAA AAA >gi|146229330|ref|NM_001085427.1|Arylsulfatase A (ARSA), transcript variant 4 AAGGGTCACAGGTCACGGGGCGGGGCCGAGGCGGAAGCGCCCGCAGCCCGGTACCGGCTCCTCCTGGGCTCCCTCTAGCG CCTTCCCCCCGGCCCGACTCCGCTGGTCAGCGCCAAGTGACTTACGCCCCCGACCCTGAGCCCGGACCGCTAGGCGAGGA GGATCAGATCTCCGCTCGAGAATCTGAAGACCCCTCGGTCCCATGTCCATGGGGGCACCGCGGTCCCTCCTCCTGGCCCT GGCTGCTGGCCTGGCCGTTGCCCGTCCGCCCAACATCGTGCTGATCTTTGCCGACGACCTCGGCTATGGGGACCTGGGCT GCTATGGGCACCCCAGCTCTACCACTCCCAACCTGGACCAGCTGGCGGCGGGAGGGCTGCGGTTCACAGACTTCTACGTG CCTGTGTCTCTGTGCACACCCTCTAGGGCCGCCCTCCTGACCGGCCGGCTCCCGGTTCGGATGGGCATGTACCCTGGCGT CCTGGTGCCCAGCTCCCGGGGGGGCCTGCCCCTGGAGGAGGTGACCGTGGCCGAAGTCCTGGCTGCCCGAGGCTACCTCA CAGGAATGGCCGGCAAGTGGCACCTTGGGGTGGGGCCTGAGGGGGCCTTCCTGCCCCCCCATCAGGGCTTCCATCGATTT CTAGGCATCCCGTACTCCCACGACCAGGGCCCCTGCCAGAACCTGACCTGCTTCCCGCCGGCCACTCCTTGCGACGGTGG CTGTGACCAGGGCCTGGTCCCCATCCCACTGTTGGCCAACCTGTCCGTGGAGGCGCAGCCCCCCTGGCTGCCCGGACTAG AGGCCCGCTACATGGCTTTCGCCCATGACCTCATGGCCGACGCCCAGCGCCAGGATCGCCCCTTCTTCCTGTACTATGCC TCTCACCACACCCACTACCCTCAGTTCAGTGGGCAGAGCTTTGCAGAGCGTTCAGGCCGCGGGCCATTTGGGGACTCCCT GATGGAGCTGGATGCAGCTGTGGGGACCCTGATGACAGCCATAGGGGACCTGGGGCTGCTTGAAGAGACGCTGGTCATCT TCACTGCAGACAATGGACCTGAGACCATGCGTATGTCCCGAGGCGGCTGCTCCGGTCTCTTGCGGTGTGGAAAGGGAACG ACCTACGAGGGCGGTGTCCGAGAGCCTGCCTTGGCCTTCTGGCCAGGTCATATCGCTCCCGGCGTGACCCACGAGCTGGC CAGCTCCCTGGACCTGCTGCCTACCCTGGCAGCCCTGGCTGGGGCCCCACTGCCCAATGTCACCTTGGATGGCTTTGACC TCAGCCCCCTGCTGCTGGGCACAGGCAAGAGCCCTCGGCAGTCTCTCTTCTTCTACCCGTCCTACCCAGACGAGGTCCGT GGGGTTTTTGCTGTGCGGACTGGAAAGTACAAGGCTCACTTCTTCACCCAGGGCTCTGCCCACAGTGATACCACTGCAGA CCCTGCCTGCCACGCCTCCAGCTCTCTGACTGCTCATGAGCCCCCGCTGCTCTATGACCTGTCCAAGGACCCTGGTGAGA ACTACAACCTGCTGGGGGGTGTGGCCGGGGCCACCCCAGAGGTGCTGCAAGCCCTGAAACAGCTTCAGCTGCTCAAGGCC CAGTTAGACGCAGCTGTGACCTTCGGCCCCAGCCAGGTGGCCCGGGGCGAGGACCCCGCCCTGCAGATCTGCTGTCATCC TGGCTGCACCCCCCGCCCAGCTTGCTGCCATTGCCCAGATCCCCATGCCTGAGGGCCCCTCGGCTGGCCTGGGCATGTGA TGGCTCCTCACTGGGAGCCTGTGGGGGAGGCTCAGGTGTCTGGAGGGGGTTTGTGCCTGATAACGTAATAACACCAGTGG AGACTTGCAGATGTGAAAAAAAAAAAAAAAAAA

	ARSA, mRNA isoform 5 - Generality top
	Primary source RefSeq : NM_001085428.1 (GI:146229326) Name Arylsulfatase A (ARSA), transcript variant 5 Type of transcript mRNA Organism Homo sapiens Length 1681 nt Map 22q13.33 Location Chromosome 22 (NC_000022.10)  strand : - 51063448...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065833   51066373...51066606
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1b 1 234 234 1 Exon 2 235 475 241 1 Exon 3 476 694 219 1 Exon 4 695 864 170 1 Exon 5 865 989 125 1 Exon 6 990 1117 128 1 Exon 7 1118 1220 103 1 Exon 8 1221 1664 444 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS46736 Nucleotide ARSA, mRNA isoform 5[NM_001085428.1] : 269...1540 Length 1272 Location Chromosome 22 (NC_000022.10)  strand : - 51063572...51063891   51064006...51064108   51064363...51064490   51064581...51064705   51065018...51065187   51065261...51065479   51065593...51065799   Start codon 1 Translation NP_001078897.1
	Sequence top
	FASTA 1  AAGGGTCACA GGTCACGGGG CGGGGCCGAG GCGGAAGCGC CCGCAGCCCG GTACCGGCTC CTCCTGGGCT CCCTCTAGCG 81  CCTTCCCCCC GGCCCGACTC CGCTGGTCAG CGCCAAGTGA CTTACGCCCC CGACCCTGAG CCCGGACCGC TAGGCGAGGA 161  GGATCAGATC TCCGCTCGAG AATCTGAAGG TGCCCTGGTC CTGGAGGAGT TCCGTCCCAG CCCGCGGTCT CCCGGGCCGC 241  CCTCCTGACC GGCCGGCTCC CGGTTCGGAT GGGCATGTAC CCTGGCGTCC TGGTGCCCAG CTCCCGGGGG GGCCTGCCCC 321  TGGAGGAGGT GACCGTGGCC GAAGTCCTGG CTGCCCGAGG CTACCTCACA GGAATGGCCG GCAAGTGGCA CCTTGGGGTG 401  GGGCCTGAGG GGGCCTTCCT GCCCCCCCAT CAGGGCTTCC ATCGATTTCT AGGCATCCCG TACTCCCACG ACCAGGGCCC 481  CTGCCAGAAC CTGACCTGCT TCCCGCCGGC CACTCCTTGC GACGGTGGCT GTGACCAGGG CCTGGTCCCC ATCCCACTGT 561  TGGCCAACCT GTCCGTGGAG GCGCAGCCCC CCTGGCTGCC CGGACTAGAG GCCCGCTACA TGGCTTTCGC CCATGACCTC 641  ATGGCCGACG CCCAGCGCCA GGATCGCCCC TTCTTCCTGT ACTATGCCTC TCACCACACC CACTACCCTC AGTTCAGTGG 721  GCAGAGCTTT GCAGAGCGTT CAGGCCGCGG GCCATTTGGG GACTCCCTGA TGGAGCTGGA TGCAGCTGTG GGGACCCTGA 801  TGACAGCCAT AGGGGACCTG GGGCTGCTTG AAGAGACGCT GGTCATCTTC ACTGCAGACA ATGGACCTGA GACCATGCGT 881  ATGTCCCGAG GCGGCTGCTC CGGTCTCTTG CGGTGTGGAA AGGGAACGAC CTACGAGGGC GGTGTCCGAG AGCCTGCCTT 961  GGCCTTCTGG CCAGGTCATA TCGCTCCCGG CGTGACCCAC GAGCTGGCCA GCTCCCTGGA CCTGCTGCCT ACCCTGGCAG 1041  CCCTGGCTGG GGCCCCACTG CCCAATGTCA CCTTGGATGG CTTTGACCTC AGCCCCCTGC TGCTGGGCAC AGGCAAGAGC 1121  CCTCGGCAGT CTCTCTTCTT CTACCCGTCC TACCCAGACG AGGTCCGTGG GGTTTTTGCT GTGCGGACTG GAAAGTACAA 1201  GGCTCACTTC TTCACCCAGG GCTCTGCCCA CAGTGATACC ACTGCAGACC CTGCCTGCCA CGCCTCCAGC TCTCTGACTG 1281  CTCATGAGCC CCCGCTGCTC TATGACCTGT CCAAGGACCC TGGTGAGAAC TACAACCTGC TGGGGGGTGT GGCCGGGGCC 1361  ACCCCAGAGG TGCTGCAAGC CCTGAAACAG CTTCAGCTGC TCAAGGCCCA GTTAGACGCA GCTGTGACCT TCGGCCCCAG 1441  CCAGGTGGCC CGGGGCGAGG ACCCCGCCCT GCAGATCTGC TGTCATCCTG GCTGCACCCC CCGCCCAGCT TGCTGCCATT 1521  GCCCAGATCC CCATGCCTGA GGGCCCCTCG GCTGGCCTGG GCATGTGATG GCTCCTCACT GGGAGCCTGT GGGGGAGGCT 1601  CAGGTGTCTG GAGGGGGTTT GTGCCTGATA ACGTAATAAC ACCAGTGGAG ACTTGCAGAT GTGAAAAAAA AAAAAAAAAA 1681  A >gi|146229326|ref|NM_001085428.1|Arylsulfatase A (ARSA), transcript variant 5 AAGGGTCACAGGTCACGGGGCGGGGCCGAGGCGGAAGCGCCCGCAGCCCGGTACCGGCTCCTCCTGGGCTCCCTCTAGCG CCTTCCCCCCGGCCCGACTCCGCTGGTCAGCGCCAAGTGACTTACGCCCCCGACCCTGAGCCCGGACCGCTAGGCGAGGA GGATCAGATCTCCGCTCGAGAATCTGAAGGTGCCCTGGTCCTGGAGGAGTTCCGTCCCAGCCCGCGGTCTCCCGGGCCGC CCTCCTGACCGGCCGGCTCCCGGTTCGGATGGGCATGTACCCTGGCGTCCTGGTGCCCAGCTCCCGGGGGGGCCTGCCCC TGGAGGAGGTGACCGTGGCCGAAGTCCTGGCTGCCCGAGGCTACCTCACAGGAATGGCCGGCAAGTGGCACCTTGGGGTG GGGCCTGAGGGGGCCTTCCTGCCCCCCCATCAGGGCTTCCATCGATTTCTAGGCATCCCGTACTCCCACGACCAGGGCCC CTGCCAGAACCTGACCTGCTTCCCGCCGGCCACTCCTTGCGACGGTGGCTGTGACCAGGGCCTGGTCCCCATCCCACTGT TGGCCAACCTGTCCGTGGAGGCGCAGCCCCCCTGGCTGCCCGGACTAGAGGCCCGCTACATGGCTTTCGCCCATGACCTC ATGGCCGACGCCCAGCGCCAGGATCGCCCCTTCTTCCTGTACTATGCCTCTCACCACACCCACTACCCTCAGTTCAGTGG GCAGAGCTTTGCAGAGCGTTCAGGCCGCGGGCCATTTGGGGACTCCCTGATGGAGCTGGATGCAGCTGTGGGGACCCTGA TGACAGCCATAGGGGACCTGGGGCTGCTTGAAGAGACGCTGGTCATCTTCACTGCAGACAATGGACCTGAGACCATGCGT ATGTCCCGAGGCGGCTGCTCCGGTCTCTTGCGGTGTGGAAAGGGAACGACCTACGAGGGCGGTGTCCGAGAGCCTGCCTT GGCCTTCTGGCCAGGTCATATCGCTCCCGGCGTGACCCACGAGCTGGCCAGCTCCCTGGACCTGCTGCCTACCCTGGCAG CCCTGGCTGGGGCCCCACTGCCCAATGTCACCTTGGATGGCTTTGACCTCAGCCCCCTGCTGCTGGGCACAGGCAAGAGC CCTCGGCAGTCTCTCTTCTTCTACCCGTCCTACCCAGACGAGGTCCGTGGGGTTTTTGCTGTGCGGACTGGAAAGTACAA GGCTCACTTCTTCACCCAGGGCTCTGCCCACAGTGATACCACTGCAGACCCTGCCTGCCACGCCTCCAGCTCTCTGACTG CTCATGAGCCCCCGCTGCTCTATGACCTGTCCAAGGACCCTGGTGAGAACTACAACCTGCTGGGGGGTGTGGCCGGGGCC ACCCCAGAGGTGCTGCAAGCCCTGAAACAGCTTCAGCTGCTCAAGGCCCAGTTAGACGCAGCTGTGACCTTCGGCCCCAG CCAGGTGGCCCGGGGCGAGGACCCCGCCCTGCAGATCTGCTGTCATCCTGGCTGCACCCCCCGCCCAGCTTGCTGCCATT GCCCAGATCCCCATGCCTGAGGGCCCCTCGGCTGGCCTGGGCATGTGATGGCTCCTCACTGGGAGCCTGTGGGGGAGGCT CAGGTGTCTGGAGGGGGTTTGTGCCTGATAACGTAATAACACCAGTGGAGACTTGCAGATGTGAAAAAAAAAAAAAAAAA A

	P15289 - Generality top
	Primary source Uniprot : P15289 Name Arylsulfatase A Alternative name(s) Cerebroside-sulfatase Synonym(s) ASA Organism Homo sapiens Length 507 aa Protein existence ---
	External Links top
	ArrayExpress P15289   BRENDA 3.1.6.8   Refseq NP_001078896.1   NP_001078895.1   NP_001078894.1   NP_000478.2   Uniprot P15289   GlycoSuiteDB P15289   InterPro IPR000917   IPR017850   IPR017849   KEGG hsa:410   PDB 2AIK   2AIJ   1N2L   1N2K   1E3C   1E33   1E2S   1E1Z   1AUK   PDBsum 2AIK   2AIJ   1N2L   1N2K   1E3C   1E33   1E2S   1E1Z   1AUK   PROSITE PS00149   PS00523   Pfam PF00884   SUPFAM SSF53649
	General annotation (Comments) top
	Catalytic activity A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate. Cofactor Binds 1 calcium ion per subunit. Disease Defects in ARSA are a cause of leukodystrophy metachromatic (MLD) [MIM:250100]. MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tissues, with a diffuse loss of myelin in the central nervous system. Progressive demyelination causes a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Three forms of the disease can be distinguished according to the age at onset: late- infantile, juvenile and adult. Arylsulfatase A activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post- translational modification of a highly conserved cysteine into 3- oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay. Enzyme regulation Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine. Function Hydrolyzes cerebroside sulfate. Ptm The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD). Similarity Belongs to the sulfatase family. Subcellular location Lysosome. Subunit Homodimer at neutral pH and homooctamer at acidic pH. Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). Interacts with SUMF1.
	Ontologies top
	Cellular component lysosome [GO:0005764] Molecular function arylsulfatase activity [GO:0004065] cerebroside-sulfatase activity [GO:0004098] calcium ion binding [GO:0005509]
	Binary interactions top
	With Uniprot accession IntAct
	Alternative product(s) top
	Sequence annotation top
	Feature key Position Length Description Feature identifier Molecule processing           Signal 1 - 18 18 P15289-SIGNAL-1 Sites           Active site 125 - 125 1 P15289-ACT_SITE-125 Binding site 123 - 123 1 Substrate P15289-BINDING-123 Binding site 150 - 150 1 Substrate P15289-BINDING-150 Binding site 229 - 229 1 Substrate P15289-BINDING-229 Binding site 302 - 302 1 Substrate P15289-BINDING-302 Metal binding 29 - 29 1 Calcium P15289-METAL-29 Metal binding 30 - 30 1 Calcium P15289-METAL-30 Metal binding 69 - 69 1 Calcium; via 3-oxoalanine P15289-METAL-69 Metal binding 281 - 281 1 Calcium P15289-METAL-281 Metal binding 282 - 282 1 Calcium P15289-METAL-282 Natural variations           Natural variant site 18 - 18 1 A -> D (in MLD; enzyme activity reduced to 5% of wild-type enzyme) VAR_054164 Natural variant site 29 - 29 1 D -> N (in MLD; infantile-onset; causes a severe reduction of enzyme activity) VAR_054165 Natural variant site 30 - 30 1 D -> H (in MLD; enzyme activity reduced to 2.4% of wild-type enzyme) VAR_054166 Natural variant site 32 - 32 1 G -> S (in MLD; late-infantile form) VAR_054167 Natural variant site 68 - 68 1 L -> P (in MLD; late-infantile form) VAR_054168 Natural variant site 76 - 76 1 L -> P VAR_007243 Natural variant site 82 - 82 1 P -> L (in MLD; late-infantile-onset; dbSNP:rs6151411) VAR_007244 Natural variant site 84 - 84 1 R -> Q (in MLD; mild) VAR_007245 Natural variant site 84 - 84 1 R -> W (in MLD; juvenile form) VAR_054169 Natural variant site 86 - 86 1 G -> D (in MLD; severe; no enzyme residual activity; leads to a decreased stability of the mutant enzyme; causes an arrest of the mutant enzyme polypeptide in a prelysosomal compartment) VAR_007246 Natural variant site 94 - 94 1 P -> A (in MLD; adult form) VAR_054170 Natural variant site 95 - 95 1 S -> N (in MLD) VAR_007247 Natural variant site 96 - 96 1 S -> L (in MLD; severe; no enzyme residual activity) VAR_007249 Natural variant site 96 - 96 1 S -> F (in MLD; severe) VAR_007248 Natural variant site 99 - 99 1 G -> D (in MLD; adult type) VAR_007250 Natural variant site 99 - 99 1 G -> V (in MLD; late-infantile form) VAR_054171 Natural variant site 119 - 119 1 G -> R (in MLD; juvenile-onset) VAR_007251 Natural variant site 122 - 122 1 G -> S (in MLD; adult type) VAR_007252 Natural variant site 135 - 135 1 L -> P (in MLD) VAR_007253 Natural variant site 136 - 136 1 P -> L (in MLD; severe late-infantile type; loss of enzymatic activity) VAR_007254 Natural variant site 136 - 136 1 P -> S (in MLD; late-infantile form) VAR_054172 Natural variant site 137 - 137 1 Missing (in MLD) VAR_054173 Natural variant site 143 - 143 1 R -> G (in MLD; juvenile/adult-onset; generates 5% as much activity as the parallel normal control) VAR_054174 Natural variant site 148 - 148 1 P -> L (in MLD; juvenile-onset) VAR_054175 Natural variant site 152 - 152 1 D -> Y (in MLD) VAR_007255 Natural variant site 153 - 153 1 Q -> H (in MLD; late-infantile form; no enzyme residual activity) VAR_054176 Natural variant site 154 - 154 1 G -> D (in MLD) VAR_007256 Natural variant site 155 - 155 1 P -> R (in MLD) VAR_007257 Natural variant site 155 - 155 1 P -> L (in MLD; juvenile-onset) VAR_054177 Natural variant site 156 - 156 1 C -> R (in MLD; adult type; enzyme activity reduced to 50% of wild-type enzyme) VAR_054178 Natural variant site 167 - 167 1 P -> R (in MLD) VAR_007258 Natural variant site 169 - 169 1 D -> N (in MLD) VAR_007259 Natural variant site 172 - 172 1 C -> Y (in MLD; juvenile-onset) VAR_007260 Natural variant site 179 - 179 1 I -> S (in MLD; mild) VAR_007261 Natural variant site 181 - 181 1 L -> Q (in MLD; infantile form) VAR_054179 Natural variant site 190 - 190 1 Q -> H (in MLD; no enzyme residual activity) VAR_054180 Natural variant site 191 - 191 1 P -> T (in MLD; juvenile-onset) VAR_054181 Natural variant site 193 - 193 1 W -> C (in dbSNP:rs6151415) VAR_007262 Natural variant site 201 - 201 1 Y -> C (in MLD; juvenile-onset; low amounts of residual enzyme activity; leads to a decreased stability of the mutant enzyme; causes an arrest of the mutant enzyme polypeptide in a prelysosomal compartment) VAR_007263 Natural variant site 212 - 212 1 A -> P (in MLD; enzyme activity reduced to 2.6% of wild-type enzyme) VAR_054182 Natural variant site 212 - 212 1 A -> V (in MLD) VAR_007264 Natural variant site 217 - 217 1 R -> H (in MLD; enzyme activity reduced to 15.6% of wild-type enzyme) VAR_054183 Natural variant site 219 - 219 1 F -> V (in MLD; enzyme activity reduced to less than 1% of normal activity) VAR_054184 Natural variant site 224 - 224 1 A -> V (in MLD) VAR_007265 Natural variant site 227 - 227 1 H -> Y (in MLD; late-infantile form) VAR_054185 Natural variant site 231 - 231 1 P -> T (in MLD) VAR_007266 Natural variant site 244 - 244 1 R -> H (in MLD; infantile-onset) VAR_007268 Natural variant site 244 - 244 1 R -> C (in MLD; juvenile-onset) VAR_007267 Natural variant site 245 - 245 1 G -> R (in MLD; severe; represents 20% of all alleles among Australians and about 85% of all Australians Lebanese alleles) VAR_007269 Natural variant site 247 - 247 1 F -> S (in MLD) VAR_054186 Natural variant site 250 - 250 1 S -> Y (in MLD; infantile-onset) VAR_007270 Natural variant site 253 - 253 1 E -> K (in MLD; late-infantile) VAR_054187 Natural variant site 255 - 255 1 D -> H (in MLD; late-infantile form; no enzyme residual activity; leads to a decreased stability of the mutant enzyme; causes an arrest of the mutant enzyme polypeptide in a prelysosomal compartment) VAR_054188 Natural variant site 274 - 274 1 T -> M (in MLD; severe; 35% of normal activity) VAR_007271 Natural variant site 281 - 281 1 D -> Y (in MLD) VAR_054189 Natural variant site 282 - 282 1 N -> S (in MLD; enzyme activity reduced to 0.6% of wild-type enzyme) VAR_054190 Natural variant site 286 - 286 1 T -> P (in MLD; adult type; dbSNP:rs28940894) VAR_054191 Natural variant site 288 - 288 1 R -> H (in MLD; adult form) VAR_054192 Natural variant site 288 - 288 1 R -> C (in MLD) VAR_007272 Natural variant site 293 - 293 1 G -> S (in MLD; adult type; causes a severe reduction of enzyme activity) VAR_054194 Natural variant site 293 - 293 1 G -> D (in MLD; late-onset) VAR_054193 Natural variant site 294 - 294 1 C -> Y (in MLD; juvenile-onset; causes a severe reduction of enzyme activity) VAR_054195 Natural variant site 295 - 295 1 S -> Y (in MLD; severe) VAR_007273 Natural variant site 298 - 298 1 L -> S (in MLD; late-infantile form; complete loss of enzyme activity) VAR_054196 Natural variant site 300 - 300 1 C -> F (in MLD; late-infantile-onset; enzyme activity reduced to less than 1%; the mutant protein is unstable; results in more rapid enzyme degradation in lysosomes; addition of the cysteine protease inhibitor leupeptin does not increase the amount of the enzyme activity; strongly interferes with the octamerization process of the enzyme at low pH) VAR_008132 Natural variant site 302 - 302 1 K -> N (in MLD; enzyme activity reduced to 2.8% of wild-type enzyme) VAR_054197 Natural variant site 306 - 306 1 Y -> H (in MLD; juvenile-onset) VAR_054198 Natural variant site 308 - 308 1 G -> V (in MLD; late-infantile form; no enzyme residual activity) VAR_054200 Natural variant site 308 - 308 1 G -> D (in MLD; late-infantile form) VAR_054199 Natural variant site 309 - 309 1 G -> S (in MLD; severe; 13% of normal activity) VAR_007274 Natural variant site 311 - 311 1 R -> Q (in MLD; juvenile-onset) VAR_007275 Natural variant site 312 - 312 1 E -> D (in MLD; low amounts of residual enzyme activity; leads to a decreased stability of the mutant enzyme) VAR_054201 Natural variant site 314 - 314 1 A -> T (in MLD; infantile-onset) VAR_007276 Natural variant site 325 - 325 1 G -> S (in MLD; juvenile-onset) VAR_054202 Natural variant site 327 - 327 1 T -> I (in MLD; late-infantile form) VAR_054203 Natural variant site 335 - 335 1 D -> V (in MLD; late-infantile-onset; loss of enzymatic activity) VAR_007277 Natural variant site 350 - 350 1 N -> S (associated with arylsulfatase A pseudodeficiency; appeares to be responsible for the small size of the enzyme produced by pseudodeficiency fibroblasts because it leads to loss of an N-glycosylation site; dbSNP:rs2071421) VAR_007278 Natural variant site 356 - 356 1 F -> V (in dbSNP:rs6151422) VAR_018838 Natural variant site 367 - 367 1 K -> N (in MLD) VAR_007279 Natural variant site 370 - 370 1 R -> W (in MLD; severe; no enzyme residual activity) VAR_007281 Natural variant site 370 - 370 1 R -> Q (in MLD; mild) VAR_007280 Natural variant site 376 - 376 1 Y -> N (in MLD; enzyme activity reduced to 4.7% of wild-type enzyme) VAR_054204 Natural variant site 377 - 377 1 P -> L (in MLD; severe; high frequency among Habbanite Jews) VAR_007282 Natural variant site 381 - 381 1 D -> E (in MLD; early-infantile form) VAR_054205 Natural variant site 382 - 382 1 E -> K (in MLD; intermediate) VAR_007283 Natural variant site 384 - 384 1 R -> C (in MLD) VAR_007284 Natural variant site 390 - 390 1 R -> W (in MLD; late-infantile and juvenile-onset) VAR_007286 Natural variant site 390 - 390 1 R -> Q (in MLD; juvenile-onset) VAR_007285 Natural variant site 391 - 391 1 T -> S (in dbSNP:rs743616) VAR_007287 Natural variant site 397 - 397 1 H -> Y (in MLD; adult-onset) VAR_007288 Natural variant site 398 - 398 1 Missing (in MLD) VAR_007289 Natural variant site 406 - 408 3 Missing (in MLD; late-infantile-onset) VAR_007290 Natural variant site 408 - 408 1 T -> I (in MLD; adult type; dbSNP:rs28940895) VAR_054206 Natural variant site 409 - 409 1 T -> I (in MLD; mild) VAR_054207 Natural variant site 425 - 425 1 P -> T (in MLD; juvenile-onset; retains about 12% of specific enzyme activity; the mutant protein is unstable; results in more rapid enzyme degradation in lysosomes; addition of the cysteine protease inhibitor leupeptin increases the amount of the enzyme activity; displays a modest reduction in the octamerization process of the enzyme at low pH) VAR_008133 Natural variant site 426 - 426 1 P -> L (in MLD; juvenile/adult-onset; mild; common mutation; dbSNP:rs28940893) VAR_007291 Natural variant site 428 - 428 1 L -> P (in MLD; late-infantile form) VAR_054208 Natural variant site 429 - 429 1 Y -> S (in MLD; adult-onset) VAR_054209 Natural variant site 440 - 440 1 N -> S (in dbSNP:rs6151427) VAR_018839 Natural variant site 464 - 464 1 A -> V VAR_007292 Natural variant site 469 - 469 1 A -> G (in MLD; early-infantile form) VAR_054210 Natural variant site 489 - 489 1 C -> G (in MLD; late-onset) VAR_054211 Natural variant site 496 - 496 1 R -> H (in dbSNP:rs6151428) VAR_007293 Amino acid modifications           Disulfide bond 156 - 172 17 P15289-DISULFID-156 Disulfide bond 161 - 168 8 P15289-DISULFID-161 Disulfide bond 300 - 414 115 P15289-DISULFID-300 Disulfide bond 488 - 500 13 P15289-DISULFID-488 Disulfide bond 489 - 502 14 P15289-DISULFID-489 Disulfide bond 493 - 499 7 P15289-DISULFID-493 Glycosylation 158 - 158 1 N-linked (GlcNAc...) P15289-CARBOHYD-158 Glycosylation 184 - 184 1 N-linked (GlcNAc...) P15289-CARBOHYD-184 Glycosylation 350 - 350 1 N-linked (GlcNAc...) P15289-CARBOHYD-350 Modified residue 69 - 69 1 3-oxoalanine (Cys) P15289-MOD_RES-69 Experimental info           Mutagenesis 69 - 69 1 C->S: Strongly decreases enzyme activity P15289-MUTAGEN-69
	Sequence top
	FASTA 1  MGAPRSLLLA LAAGLAVARP PNIVLIFADD LGYGDLGCYG HPSSTTPNLD QLAAGGLRFT DFYVPVSLCT PSRAALLTGR 81  LPVRMGMYPG VLVPSSRGGL PLEEVTVAEV LAARGYLTGM AGKWHLGVGP EGAFLPPHQG FHRFLGIPYS HDQGPCQNLT 161  CFPPATPCDG GCDQGLVPIP LLANLSVEAQ PPWLPGLEAR YMAFAHDLMA DAQRQDRPFF LYYASHHTHY PQFSGQSFAE 241  RSGRGPFGDS LMELDAAVGT LMTAIGDLGL LEETLVIFTA DNGPETMRMS RGGCSGLLRC GKGTTYEGGV REPALAFWPG 321  HIAPGVTHEL ASSLDLLPTL AALAGAPLPN VTLDGFDLSP LLLGTGKSPR QSLFFYPSYP DEVRGVFAVR TGKYKAHFFT 401  QGSAHSDTTA DPACHASSSL TAHEPPLLYD LSKDPGENYN LLGGVAGATP EVLQALKQLQ LLKAQLDAAV TFGPSQVARG 481  EDPALQICCH PGCTPRPACC HCPDPHA >sp|P15289|ARSA_human Arylsulfatase A MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLT CFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPG HIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFT QGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG EDPALQICCHPGCTPRPACCHCPDPHA