(ARSA) arylsulfatase A [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  10821
 Official symbol  ARSA
 Official name  arylsulfatase A
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 22 (NC_000022.10) :  51063448...51066606  (-)
 Map  22q13.31-qter
 Length  3159  nt
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Alternative name(s) and Synynom(s) top
Synonyms MLD
Alternative name(s) metachromatic leucodystrophy
External Links top
EC_number 3.1.6.8
Ensembl ENSG00000100299
Entrez 410
HGNC 713
HPRD 09617
Comment top
Summary The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Multiple alternatively spliced transcript variants, one of which encodes a distinct protein, have been described for this gene. [provided by RefSeq].
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Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
AGGGTCACAG GTCACGGGGC GGGGCCGAGG CGGAAGCGCC CGCAGCCCGG TACCGGCTCC TCCTGGGCTC CCTCTAGCGC
81  CTTCCCCCCG GCCCGACTCC GCTGGTCAGC GCCAAGTGAC TTACGCCCCC GACCCTGAGC CCGGACCGCT AGGCGAGGAG
161  GATCAGATCT CCGCTCGAGA ATCTGAAGGT GCCCTGGTCC TGGAGGAGTT CCGTCCCAGC CCGCGGTCTC CCGGTACTGT
241  CGGGCCCCGG CCCTCTGGAG CTTCAGGAGG CGGCCGTCAG GGTCGGGGAG TATTTGGGTC CGGGGTCTCA GGGAAGGGCG
321  GCGCCTGGGT CTGCGGTATC GGAAAGAGCC TGCTGGAGCC AAGTAGCCCT CCCTCTCTTG GGACAGACCC CTCGGTCCCA
401  TGTCCATGGG GGCACCGCGG TCCCTCCTCC TGGCCCTGGC TGCTGGCCTG GCCGTTGCCC GTCCGCCCAA CATCGTGCTG
481  ATCTTTGCCG ACGACCTCGG CTATGGGGAC CTGGGCTGCT ATGGGCACCC CAGCTCTACC ACTCCCAACC TGGACCAGCT
561  GGCGGCGGGA GGGCTGCGGT TCACAGACTT CTACGTGCCT GTGTCTCTGT GCACACCCTC TAGGTAAAGA GGGGGCCGCG
641  CCTCTTCCCC GCCCCGACCC TCCATCCCTT TCCTCCCAAT GGATTGCAGG GGGGCGGGAA AAACGTCTGT CTCTCTCTCT
721  AGGGAAGGCC ACATTTCTGT CTGTCTCAGG GACTCTGTGA CTTGTCCCGC AGGGCCGCCC TCCTGACCGG CCGGCTCCCG
801  GTTCGGATGG GCATGTACCC TGGCGTCCTG GTGCCCAGCT CCCGGGGGGG CCTGCCCCTG GAGGAGGTGA CCGTGGCCGA
881  AGTCCTGGCT GCCCGAGGCT ACCTCACAGG AATGGCCGGC AAGTGGCACC TTGGGGTGGG GCCTGAGGGG GCCTTCCTGC
961  CCCCCCATCA GGGCTTCCAT CGATTTCTAG GCATCCCGTA CTCCCACGAC CAGGTAGGAA CCACCCGGGC CCTCAGCCAC
1041  CCTCCCACCT CCCAAAGTCC CCCAGCCCTT GATGCTCCCG CAGCCCCACC TGCCAGCCCA GCCCTCACGG CAGCTGCCCG
1121  CCTCAGGGCC CCTGCCAGAA CCTGACCTGC TTCCCGCCGG CCACTCCTTG CGACGGTGGC TGTGACCAGG GCCTGGTCCC
1201  CATCCCACTG TTGGCCAACC TGTCCGTGGA GGCGCAGCCC CCCTGGCTGC CCGGACTAGA GGCCCGCTAC ATGGCTTTCG
1281  CCCATGACCT CATGGCCGAC GCCCAGCGCC AGGATCGCCC CTTCTTCCTG TACTATGCCT CTCACGTAAG TGATCTTGGC
1361  CCAACCCCCT GGCTGCCCGT GACCCCTACC CAGTGCTAAC TCCAGTCTTT GCCCCCAGCA CACCCACTAC CCTCAGTTCA
1441  GTGGGCAGAG CTTTGCAGAG CGTTCAGGCC GCGGGCCATT TGGGGACTCC CTGATGGAGC TGGATGCAGC TGTGGGGACC
1521  CTGATGACAG CCATAGGGGA CCTGGGGCTG CTTGAAGAGA CGCTGGTCAT CTTCACTGCA GACAATGGGT ATGCCAGCAG
1601  GGCAGCTGGG TGCTCCGGCC CTGTCACGGG CCAGGGCCCT GGAGGCCTTG CAGTTCAGCT GCTTGCCAAG AACATAGTGG
1681  GTGAGGGGGT GCCAGGAGAT GCTGGCCACG TTGCAGGGGC CCAAGGTGTA GTCAGGAGAC ACAGTGCACA GAGAGCTGGT
1761  CTTGGTAGGC CTGGGAGGTG CCGGGCTCAT GCTGGGCACC TCCGGGCAAG CTTTGTGACT TAGAGGTGTG GGGCCACTGG
1841  TCACCCTCGG TGGCTCAGAG GCTGTGGCTC CATGGCTCAT GAGCGCCTCC TGTGTCCCAG ACCTGAGACC ATGCGTATGT
1921  CCCGAGGCGG CTGCTCCGGT CTCTTGCGGT GTGGAAAGGG AACGACCTAC GAGGGCGGTG TCCGAGAGCC TGCCTTGGCC
2001  TTCTGGCCAG GTCATATCGC TCCCGGTCAG TCCGCAGGCC CTCTCCTTGG AACCCTGGCC CCACCACCCC AACCTTGATG
2081  GCGAACTGAG TGACTGACCA GCCTCCTGCC CCCAGGCGTG ACCCACGAGC TGGCCAGCTC CCTGGACCTG CTGCCTACCC
2161  TGGCAGCCCT GGCTGGGGCC CCACTGCCCA ATGTCACCTT GGATGGCTTT GACCTCAGCC CCCTGCTGCT GGGCACAGGC
2241  AAGGTAGGGC CGGTGACCCC TGATCCCAGA TCCTTGGCCC CTGTCCTGGC CTTCCCCTGG GGTGAGTGTG GGCAGTGCCT
2321  GAGAGTCTGT GCCTCAGTGC CTCCTGCACT GAGTGGCATC CAAGTGGCGC CACCTCTCAG GTTCCTGGGT GGGCAAGAAG
2401  CGGTGCACGT CCAGGGCCTC CCACCAGGGC TGGCAGCCCC AGGTATGTGC AGTGCTTGGG GCCTGCCCCG CCCCGTGACC
2481  CCTGACTCTG CCCCCAGAGC CCTCGGCAGT CTCTCTTCTT CTACCCGTCC TACCCAGACG AGGTCCGTGG GGTTTTTGCT
2561  GTGCGGACTG GAAAGTACAA GGCTCACTTC TTCACCCAGG GTAACCCCTC CCCGTGGATC CCTCCCCCCG ACCTGCTGAC
2641  CCCTCCCCGG AGCCCTAGAT CCCTGGCCCC TCCTCTCGCC CTTGCCCTGT GCACAGAATT GGCCCCCTCC CCAGGCTCTG
2721  CCCACAGTGA TACCACTGCA GACCCTGCCT GCCACGCCTC CAGCTCTCTG ACTGCTCATG AGCCCCCGCT GCTCTATGAC
2801  CTGTCCAAGG ACCCTGGTGA GAACTACAAC CTGCTGGGGG GTGTGGCCGG GGCCACCCCA GAGGTGCTGC AAGCCCTGAA
2881  ACAGCTTCAG CTGCTCAAGG CCCAGTTAGA CGCAGCTGTG ACCTTCGGCC CCAGCCAGGT GGCCCGGGGC GAGGACCCCG
2961  CCCTGCAGAT CTGCTGTCAT CCTGGCTGCA CCCCCCGCCC AGCTTGCTGC CATTGCCCAG ATCCCCATGC CTGAGGGCCC
3041  CTCGGCTGGC CTGGGCATGT GATGGCTCCT CACTGGGAGC CTGTGGGGGA GGCTCAGGTG TCTGGAGGGG GTTTGTGCCT
3121  GATAACGTAA TAACACCAGT GGAGACTTGC AGATGTGAC
>ref|Gene_ID:410|ARSA|NC_000022.10:51063448...51066606 (-)
AGGGTCACAGGTCACGGGGCGGGGCCGAGGCGGAAGCGCCCGCAGCCCGGTACCGGCTCCTCCTGGGCTCCCTCTAGCGC
CTTCCCCCCGGCCCGACTCCGCTGGTCAGCGCCAAGTGACTTACGCCCCCGACCCTGAGCCCGGACCGCTAGGCGAGGAG
GATCAGATCTCCGCTCGAGAATCTGAAGGTGCCCTGGTCCTGGAGGAGTTCCGTCCCAGCCCGCGGTCTCCCGGTACTGT
CGGGCCCCGGCCCTCTGGAGCTTCAGGAGGCGGCCGTCAGGGTCGGGGAGTATTTGGGTCCGGGGTCTCAGGGAAGGGCG
GCGCCTGGGTCTGCGGTATCGGAAAGAGCCTGCTGGAGCCAAGTAGCCCTCCCTCTCTTGGGACAGACCCCTCGGTCCCA
TGTCCATGGGGGCACCGCGGTCCCTCCTCCTGGCCCTGGCTGCTGGCCTGGCCGTTGCCCGTCCGCCCAACATCGTGCTG
ATCTTTGCCGACGACCTCGGCTATGGGGACCTGGGCTGCTATGGGCACCCCAGCTCTACCACTCCCAACCTGGACCAGCT
GGCGGCGGGAGGGCTGCGGTTCACAGACTTCTACGTGCCTGTGTCTCTGTGCACACCCTCTAGGTAAAGAGGGGGCCGCG
CCTCTTCCCCGCCCCGACCCTCCATCCCTTTCCTCCCAATGGATTGCAGGGGGGCGGGAAAAACGTCTGTCTCTCTCTCT
AGGGAAGGCCACATTTCTGTCTGTCTCAGGGACTCTGTGACTTGTCCCGCAGGGCCGCCCTCCTGACCGGCCGGCTCCCG
GTTCGGATGGGCATGTACCCTGGCGTCCTGGTGCCCAGCTCCCGGGGGGGCCTGCCCCTGGAGGAGGTGACCGTGGCCGA
AGTCCTGGCTGCCCGAGGCTACCTCACAGGAATGGCCGGCAAGTGGCACCTTGGGGTGGGGCCTGAGGGGGCCTTCCTGC
CCCCCCATCAGGGCTTCCATCGATTTCTAGGCATCCCGTACTCCCACGACCAGGTAGGAACCACCCGGGCCCTCAGCCAC
CCTCCCACCTCCCAAAGTCCCCCAGCCCTTGATGCTCCCGCAGCCCCACCTGCCAGCCCAGCCCTCACGGCAGCTGCCCG
CCTCAGGGCCCCTGCCAGAACCTGACCTGCTTCCCGCCGGCCACTCCTTGCGACGGTGGCTGTGACCAGGGCCTGGTCCC
CATCCCACTGTTGGCCAACCTGTCCGTGGAGGCGCAGCCCCCCTGGCTGCCCGGACTAGAGGCCCGCTACATGGCTTTCG
CCCATGACCTCATGGCCGACGCCCAGCGCCAGGATCGCCCCTTCTTCCTGTACTATGCCTCTCACGTAAGTGATCTTGGC
CCAACCCCCTGGCTGCCCGTGACCCCTACCCAGTGCTAACTCCAGTCTTTGCCCCCAGCACACCCACTACCCTCAGTTCA
GTGGGCAGAGCTTTGCAGAGCGTTCAGGCCGCGGGCCATTTGGGGACTCCCTGATGGAGCTGGATGCAGCTGTGGGGACC
CTGATGACAGCCATAGGGGACCTGGGGCTGCTTGAAGAGACGCTGGTCATCTTCACTGCAGACAATGGGTATGCCAGCAG
GGCAGCTGGGTGCTCCGGCCCTGTCACGGGCCAGGGCCCTGGAGGCCTTGCAGTTCAGCTGCTTGCCAAGAACATAGTGG
GTGAGGGGGTGCCAGGAGATGCTGGCCACGTTGCAGGGGCCCAAGGTGTAGTCAGGAGACACAGTGCACAGAGAGCTGGT
CTTGGTAGGCCTGGGAGGTGCCGGGCTCATGCTGGGCACCTCCGGGCAAGCTTTGTGACTTAGAGGTGTGGGGCCACTGG
TCACCCTCGGTGGCTCAGAGGCTGTGGCTCCATGGCTCATGAGCGCCTCCTGTGTCCCAGACCTGAGACCATGCGTATGT
CCCGAGGCGGCTGCTCCGGTCTCTTGCGGTGTGGAAAGGGAACGACCTACGAGGGCGGTGTCCGAGAGCCTGCCTTGGCC
TTCTGGCCAGGTCATATCGCTCCCGGTCAGTCCGCAGGCCCTCTCCTTGGAACCCTGGCCCCACCACCCCAACCTTGATG
GCGAACTGAGTGACTGACCAGCCTCCTGCCCCCAGGCGTGACCCACGAGCTGGCCAGCTCCCTGGACCTGCTGCCTACCC
TGGCAGCCCTGGCTGGGGCCCCACTGCCCAATGTCACCTTGGATGGCTTTGACCTCAGCCCCCTGCTGCTGGGCACAGGC
AAGGTAGGGCCGGTGACCCCTGATCCCAGATCCTTGGCCCCTGTCCTGGCCTTCCCCTGGGGTGAGTGTGGGCAGTGCCT
GAGAGTCTGTGCCTCAGTGCCTCCTGCACTGAGTGGCATCCAAGTGGCGCCACCTCTCAGGTTCCTGGGTGGGCAAGAAG
CGGTGCACGTCCAGGGCCTCCCACCAGGGCTGGCAGCCCCAGGTATGTGCAGTGCTTGGGGCCTGCCCCGCCCCGTGACC
CCTGACTCTGCCCCCAGAGCCCTCGGCAGTCTCTCTTCTTCTACCCGTCCTACCCAGACGAGGTCCGTGGGGTTTTTGCT
GTGCGGACTGGAAAGTACAAGGCTCACTTCTTCACCCAGGGTAACCCCTCCCCGTGGATCCCTCCCCCCGACCTGCTGAC
CCCTCCCCGGAGCCCTAGATCCCTGGCCCCTCCTCTCGCCCTTGCCCTGTGCACAGAATTGGCCCCCTCCCCAGGCTCTG
CCCACAGTGATACCACTGCAGACCCTGCCTGCCACGCCTCCAGCTCTCTGACTGCTCATGAGCCCCCGCTGCTCTATGAC
CTGTCCAAGGACCCTGGTGAGAACTACAACCTGCTGGGGGGTGTGGCCGGGGCCACCCCAGAGGTGCTGCAAGCCCTGAA
ACAGCTTCAGCTGCTCAAGGCCCAGTTAGACGCAGCTGTGACCTTCGGCCCCAGCCAGGTGGCCCGGGGCGAGGACCCCG
CCCTGCAGATCTGCTGTCATCCTGGCTGCACCCCCCGCCCAGCTTGCTGCCATTGCCCAGATCCCCATGCCTGAGGGCCC
CTCGGCTGGCCTGGGCATGTGATGGCTCCTCACTGGGAGCCTGTGGGGGAGGCTCAGGTGTCTGGAGGGGGTTTGTGCCT
GATAACGTAATAACACCAGTGGAGACTTGCAGATGTGAC