(MYC) v-myc myelocytomatosis viral oncogene homolog (avian) [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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4759
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Official symbol
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MYC
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Official name
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v-myc myelocytomatosis viral oncogene homolog (avian)
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 8 (NC_000008.10) : 128748315...128753673 (+)
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Map
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8q24
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Length
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5359 nt
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NM_002467.3
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MYC, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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P01106
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Myc proto-oncogene protein
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Homo sapiens
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439 aa
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Synonyms |
MRTL; c-Myc; bHLHe39
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Alternative name(s) |
myc-related translation/localization regulatory factor; avian myelocytomatosis viral oncogene homolog; non-AUG (CUG) translation initiation codon; p67 myc protein (also called c-Myc-1); v-myc avian myelocytomatosis viral oncogene homolog
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Summary |
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl
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1 |
GACCCCCGAG |
CTGTGCTGCT |
CGCGGCCGCC |
ACCGCCGGGC |
CCCGGCCGTC |
CCTGGCTCCC |
CTCCTGCCTC |
GAGAAGGGCA |
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81 |
GGGCTTCTCA |
GAGGCTTGGC |
GGGAAAAAGA |
ACGGAGGGAG |
GGATCGCGCT |
GAGTATAAAA |
GCCGGTTTTC |
GGGGCTTTAT |
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161 |
CTAACTCGCT |
GTAGTAATTC |
CAGCGAGAGG |
CAGAGGGAGC |
GAGCGGGCGG |
CCGGCTAGGG |
TGGAAGAGCC |
GGGCGAGCAG |
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241 |
AGCTGCGCTG |
CGGGCGTCCT |
GGGAAGGGAG |
ATCCGGAGCG |
AATAGGGGGC |
TTCGCCTCTG |
GCCCAGCCCT |
CCCGCTGATC |
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321 |
CCCCAGCCAG |
CGGTCCGCAA |
CCCTTGCCGC |
ATCCACGAAA |
CTTTGCCCAT |
AGCAGCGGGC |
GGGCACTTTG |
CACTGGAACT |
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401 |
TACAACACCC |
GAGCAAGGAC |
GCGACTCTCC |
CGACGCGGGG |
AGGCTATTCT |
GCCCATTTGG |
GGACACTTCC |
CCGCCGCTGC |
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481 |
CAGGACCCGC |
TTCTCTGAAA |
GGCTCTCCTT |
GCAGCTGCTT |
AGACGCTGGA |
TTTTTTTCGG |
GTAGTGGAAA |
ACCAGGTAAG |
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561 |
CACCGAAGTC |
CACTTGCCTT |
TTAATTTATT |
TTTTTATCAC |
TTTAATGCTG |
AGATGAGTCG |
AATGCCTAAA |
TAGGGTGTCT |
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641 |
TTTCTCCCAT |
TCCTGCGCTA |
TTGACACTTT |
TCTCAGAGTA |
GTTATGGTAA |
CTGGGGCTGG |
GGTGGGGGGT |
AATCCAGAAC |
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721 |
TGGATCGGGG |
TAAAGTGACT |
TGTCAAGATG |
GGAGAGGAGA |
AGGCAGAGGG |
AAAACGGGAA |
TGGTTTTTAA |
GACTACCCTT |
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801 |
TCGAGATTTC |
TGCCTTATGA |
ATATATTCAC |
GCTGACTCCC |
GGCCGGTCGG |
ACATTCCTGC |
TTTATTGTGT |
TAATTGCTCT |
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881 |
CTGGGTTTTG |
GGGGGCTGGG |
GGTTGCTTTG |
CGGTGGGCAG |
AAAGCCCCTT |
GCATCCTGAG |
CTCCTTGGAG |
TAGGGACCGC |
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961 |
ATATCGCCTG |
TGTGAGCCAG |
ATCGCTCCGC |
AGCCGCTGAC |
TTGTCCCCGT |
CTCCGGGAGG |
GCATTTAAAT |
TTCGGCTCAC |
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1041 |
CGCATTTCTG |
ACAGCCGGAG |
ACGGACACTG |
CGGCGCGTCC |
CGCCCGCCTG |
TCCCCGCGGC |
GATTCCAACC |
CGCCCTGATC |
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1121 |
CTTTTAAGAA |
GTTGGCATTT |
GGCTTTTTAA |
AAAGCAATAA |
TACAATTTAA |
AACCTGGGTC |
TCTAGAGGTG |
TTAGGACGTG |
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1201 |
GTGTTGGGTA |
GGCGCAGGCA |
GGGGAAAAGG |
GAGGCGAGGA |
TGTGTCCGAT |
TCTCCTGGAA |
TCGTTGACTT |
GGAAAAACCA |
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1281 |
GGGCGAATCT |
CCGCACCCAG |
CCCTGACTCC |
CCTGCCGCGG |
CCGCCCTCGG |
GTGTCCTCGC |
GCCCGAGATG |
CGGAGGAACT |
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1361 |
GCGAGGAGCG |
GGGCTCTGGG |
CGGTTCCAGA |
ACAGCTGCTA |
CCCTTGGTGG |
GGTGGCTCCG |
GGGGAGGTAT |
CGCAGCGGGG |
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1441 |
TCTCTGGCGC |
AGTTGCATCT |
CCGTATTGAG |
TGCGAAGGGA |
GGTGCCCCTA |
TTATTATTTG |
ACACCCCCCT |
TGTATTTATG |
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1521 |
GAGGGGTGTT |
AAAGCCCGCG |
GCTGAGCTCG |
CCACTCCAGC |
CGGCGAGAGA |
AAGAAGAAAA |
GCTGGCAAAA |
GGAGTGTTGG |
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1601 |
ACGGGGGCGG |
TACTGGGGGT |
GGGGACGGGG |
GCGGTGGAGA |
GGGAAGGTTG |
GGAGGGGCTG |
CGGTGCCGGC |
GGGGGTAGGA |
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1681 |
GAGCGGCTAG |
GGCGCGAGTG |
GGAACAGCCG |
CAGCGGAGGG |
GCCCCGGCGC |
GGAGCGGGGT |
TCACGCAGCC |
GCTAGCGCCC |
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1761 |
AGGCGCCTCT |
CGCCTTCTCC |
TTCAGGTGGC |
GCAAAACTTT |
GTGCCTTGGA |
TTTTGGCAAA |
TTGTTTTCCT |
CACCGCCACC |
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1841 |
TCCCGCGGCT |
TCTTAAGGGC |
GCCAGGGCCG |
ATTTCGATTC |
CTCTGCCGCT |
GCGGGGCCGA |
CTCCCGGGCT |
TTGCGCTCCG |
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1921 |
GGCTCCCGGG |
GGAGCGGGGG |
CTCGGCGGGC |
ACCAAGCCGC |
TGGTTCACTA |
AGTGCGTCTC |
CGAGATAGCA |
GGGGACTGTC |
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2001 |
CAAAGGGGGT |
GAAAGGGTGC |
TCCCTTTATT |
CCCCCACCAA |
GACCACCCAG |
CCGCTTTAGG |
GGATAGCTCT |
GCAAGGGGAG |
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2081 |
AGGTTCGGGA |
CTGTGGCGCG |
CACTGCGCGC |
TGCGCCAGGT |
TTCCGCACCA |
AGACCCCTTT |
AACTCAAGAC |
TGCCTCCCGC |
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2161 |
TTTGTGTGCC |
CCGCTCCAGC |
AGCCTCCCGC |
GACGATGCCC |
CTCAACGTTA |
GCTTCACCAA |
CAGGAACTAT |
GACCTCGACT |
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2241 |
ACGACTCGGT |
GCAGCCGTAT |
TTCTACTGCG |
ACGAGGAGGA |
GAACTTCTAC |
CAGCAGCAGC |
AGCAGAGCGA |
GCTGCAGCCC |
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2321 |
CCGGCGCCCA |
GCGAGGATAT |
CTGGAAGAAA |
TTCGAGCTGC |
TGCCCACCCC |
GCCCCTGTCC |
CCTAGCCGCC |
GCTCCGGGCT |
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2401 |
CTGCTCGCCC |
TCCTACGTTG |
CGGTCACACC |
CTTCTCCCTT |
CGGGGAGACA |
ACGACGGCGG |
TGGCGGGAGC |
TTCTCCACGG |
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2481 |
CCGACCAGCT |
GGAGATGGTG |
ACCGAGCTGC |
TGGGAGGAGA |
CATGGTGAAC |
CAGAGTTTCA |
TCTGCGACCC |
GGACGACGAG |
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2561 |
ACCTTCATCA |
AAAACATCAT |
CATCCAGGAC |
TGTATGTGGA |
GCGGCTTCTC |
GGCCGCCGCC |
AAGCTCGTCT |
CAGAGAAGCT |
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2641 |
GGCCTCCTAC |
CAGGCTGCGC |
GCAAAGACAG |
CGGCAGCCCG |
AACCCCGCCC |
GCGGCCACAG |
CGTCTGCTCC |
ACCTCCAGCT |
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2721 |
TGTACCTGCA |
GGATCTGAGC |
GCCGCCGCCT |
CAGAGTGCAT |
CGACCCCTCG |
GTGGTCTTCC |
CCTACCCTCT |
CAACGACAGC |
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2801 |
AGCTCGCCCA |
AGTCCTGCGC |
CTCGCAAGAC |
TCCAGCGCCT |
TCTCTCCGTC |
CTCGGATTCT |
CTGCTCTCCT |
CGACGGAGTC |
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2881 |
CTCCCCGCAG |
GGCAGCCCCG |
AGCCCCTGGT |
GCTCCATGAG |
GAGACACCGC |
CCACCACCAG |
CAGCGACTCT |
GGTAAGCGAA |
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2961 |
GCCCGCCCAG |
GCCTGTCAAA |
AGTGGGCGGC |
TGGATACCTT |
TCCCATTTTC |
ATTGGCAGCT |
TATTTAACGG |
GCCACTCTTA |
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3041 |
TTAGGAAGGA |
GAGATAGCAG |
ATCTGGAGAG |
ATTTGGGAGC |
TCATCACCTC |
TGAAACCTTG |
GGCTTTAGCG |
TTTCCTCCCA |
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3121 |
TCCCTTCCCC |
TTAGACTGCC |
CATGTTTGCA |
GCCCCCCTCC |
CCGTTTGTCT |
CCCACCCCTC |
AGGAATTTCA |
TTTAGGTTTT |
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3201 |
TAAACCTTCT |
GGCTTATCTT |
ACAACTCAAT |
CCACTTCTTC |
TTACCTCCCG |
TTAACATTTT |
AATTGCCCTG |
GGGCGGGGTG |
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3281 |
GCAGGGAGTG |
TATGAATGAG |
GATAAGAGAG |
GATTGATCTC |
TGAGAGTGAA |
TGAATTGCTT |
CCCTCTTAAC |
TTCCGAGAAG |
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3361 |
TGGTGGGATT |
TAATGAACTA |
TCTACAAAAA |
TGAGGGGCTG |
TGTTTAGAGG |
CTAGGCAGGG |
CCTGCCTGAG |
TGCGGGAGCC |
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3441 |
AGTGAACTGC |
CTCAAGAGTG |
GGTGGGCTGA |
GGAGCTGGGA |
TCTTCTCAGC |
CTATTTTGAA |
CACTGAAAAG |
CAAATCCTTG |
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3521 |
CCAAAGTTGG |
ACTTTTTTTT |
TTCTTTTATT |
CCTTCCCCCG |
CCCTCTTGGA |
CTTTTGGCAA |
AACTGCAATT |
TTTTTTTTTT |
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3601 |
TATTTTTCAT |
TTCCAGTAAA |
ATAGGGAGTT |
GCTAAAGTCA |
TACCAAGCAA |
TTTGCAGCTA |
TCATTTGCAA |
CACCTGAAGT |
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3681 |
GTTCTTGGTA |
AAGTCCCTCA |
AAAATAGGAG |
GTGCTTGGGA |
ATGTGCTTTG |
CTTTGGGTGT |
GTCCAAAGCC |
TCATTAAGTC |
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3761 |
TTAGGTAAGA |
ATTGGCATCA |
ATGTCCTATC |
CTGGGAAGTT |
GCACTTTTCT |
TGTCCATGCC |
ATAACCCAGC |
TGTCTTTCCC |
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3841 |
TTTATGAGAC |
TCTTACCTTC |
ATGGTGAGAG |
GAGTAAGGGT |
GGCTGGCTAG |
ATTGGTTCTT |
TTTTTTTTTT |
TTTCCTTTTT |
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3921 |
TAAGACGGAG |
TCTCACTCTG |
TCACTAGGCT |
GGAGTGCAGT |
GGCGCAATCA |
ACCTCCAACC |
CCCTGGTTCA |
AGAGATTCTC |
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4001 |
CTGCCTCAGC |
CTCCCAAGTA |
GCTGGGACTA |
CAGGTGCACA |
CCACCATGCC |
AGGCTAATTT |
TTGTAATTTT |
AGTAGAGATG |
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4081 |
GGGTTTCATC |
GTGTTGGCCA |
GGATGGTCTC |
TCCTGACCTC |
ACGATCCGCC |
CACCTCGGCC |
TCCCAAAGTG |
CTGGGATTAC |
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4161 |
AGGTGTGAGC |
CAGGGCACCA |
GGCTTAGATG |
TGGCTCTTTG |
GGGAGATAAT |
TTTGTCCAGA |
GACCTTTCTA |
ACGTATTCAT |
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4241 |
GCCTTGTATT |
TGTACAGCAT |
TAATCTGGTA |
ATTGATTATT |
TTAATGTAAC |
CTTGCTAAAG |
GAGTGATTTC |
TATTTCCTTT |
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4321 |
CTTAAAGAGG |
AGGAACAAGA |
AGATGAGGAA |
GAAATCGATG |
TTGTTTCTGT |
GGAAAAGAGG |
CAGGCTCCTG |
GCAAAAGGTC |
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4401 |
AGAGTCTGGA |
TCACCTTCTG |
CTGGAGGCCA |
CAGCAAACCT |
CCTCACAGCC |
CACTGGTCCT |
CAAGAGGTGC |
CACGTCTCCA |
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4481 |
CACATCAGCA |
CAACTACGCA |
GCGCCTCCCT |
CCACTCGGAA |
GGACTATCCT |
GCTGCCAAGA |
GGGTCAAGTT |
GGACAGTGTC |
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4561 |
AGAGTCCTGA |
GACAGATCAG |
CAACAACCGA |
AAATGCACCA |
GCCCCAGGTC |
CTCGGACACC |
GAGGAGAATG |
TCAAGAGGCG |
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4641 |
AACACACAAC |
GTCTTGGAGC |
GCCAGAGGAG |
GAACGAGCTA |
AAACGGAGCT |
TTTTTGCCCT |
GCGTGACCAG |
ATCCCGGAGT |
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4721 |
TGGAAAACAA |
TGAAAAGGCC |
CCCAAGGTAG |
TTATCCTTAA |
AAAAGCCACA |
GCATACATCC |
TGTCCGTCCA |
AGCAGAGGAG |
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4801 |
CAAAAGCTCA |
TTTCTGAAGA |
GGACTTGTTG |
CGGAAACGAC |
GAGAACAGTT |
GAAACACAAA |
CTTGAACAGC |
TACGGAACTC |
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4881 |
TTGTGCGTAA |
GGAAAAGTAA |
GGAAAACGAT |
TCCTTCTAAC |
AGAAATGTCC |
TGAGCAATCA |
CCTATGAACT |
TGTTTCAAAT |
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4961 |
GCATGATCAA |
ATGCAACCTC |
ACAACCTTGG |
CTGAGTCTTG |
AGACTGAAAG |
ATTTAGCCAT |
AATGTAAACT |
GCCTCAAATT |
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5041 |
GGACTTTGGG |
CATAAAAGAA |
CTTTTTTATG |
CTTACCATCT |
TTTTTTTTTC |
TTTAACAGAT |
TTGTATTTAA |
GAATTGTTTT |
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5121 |
TAAAAAATTT |
TAAGATTTAC |
ACAATGTTTC |
TCTGTAAATA |
TTGCCATTAA |
ATGTAAATAA |
CTTTAATAAA |
ACGTTTATAG |
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5201 |
CAGTTACACA |
GAATTTCAAT |
CCTAGTATAT |
AGTACCTAGT |
ATTATAGGTA |
CTATAAACCC |
TAATTTTTTT |
TATTTAAGTA |
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5281 |
CATTTTGCTT |
TTTAAAGTTG |
ATTTTTTTCT |
ATTGTTTTTA |
GAAAAAATAA |
AATAACTGGC |
AAATATATCA |
TTGAGCCAA |
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>ref|Gene_ID:4609|MYC|NC_000008.10:128748315...128753673 (+)
GACCCCCGAGCTGTGCTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGTCCCTGGCTCCCCTCCTGCCTCGAGAAGGGCA
GGGCTTCTCAGAGGCTTGGCGGGAAAAAGAACGGAGGGAGGGATCGCGCTGAGTATAAAAGCCGGTTTTCGGGGCTTTAT
CTAACTCGCTGTAGTAATTCCAGCGAGAGGCAGAGGGAGCGAGCGGGCGGCCGGCTAGGGTGGAAGAGCCGGGCGAGCAG
AGCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCGAATAGGGGGCTTCGCCTCTGGCCCAGCCCTCCCGCTGATC
CCCCAGCCAGCGGTCCGCAACCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACTTTGCACTGGAACT
TACAACACCCGAGCAAGGACGCGACTCTCCCGACGCGGGGAGGCTATTCTGCCCATTTGGGGACACTTCCCCGCCGCTGC
CAGGACCCGCTTCTCTGAAAGGCTCTCCTTGCAGCTGCTTAGACGCTGGATTTTTTTCGGGTAGTGGAAAACCAGGTAAG
CACCGAAGTCCACTTGCCTTTTAATTTATTTTTTTATCACTTTAATGCTGAGATGAGTCGAATGCCTAAATAGGGTGTCT
TTTCTCCCATTCCTGCGCTATTGACACTTTTCTCAGAGTAGTTATGGTAACTGGGGCTGGGGTGGGGGGTAATCCAGAAC
TGGATCGGGGTAAAGTGACTTGTCAAGATGGGAGAGGAGAAGGCAGAGGGAAAACGGGAATGGTTTTTAAGACTACCCTT
TCGAGATTTCTGCCTTATGAATATATTCACGCTGACTCCCGGCCGGTCGGACATTCCTGCTTTATTGTGTTAATTGCTCT
CTGGGTTTTGGGGGGCTGGGGGTTGCTTTGCGGTGGGCAGAAAGCCCCTTGCATCCTGAGCTCCTTGGAGTAGGGACCGC
ATATCGCCTGTGTGAGCCAGATCGCTCCGCAGCCGCTGACTTGTCCCCGTCTCCGGGAGGGCATTTAAATTTCGGCTCAC
CGCATTTCTGACAGCCGGAGACGGACACTGCGGCGCGTCCCGCCCGCCTGTCCCCGCGGCGATTCCAACCCGCCCTGATC
CTTTTAAGAAGTTGGCATTTGGCTTTTTAAAAAGCAATAATACAATTTAAAACCTGGGTCTCTAGAGGTGTTAGGACGTG
GTGTTGGGTAGGCGCAGGCAGGGGAAAAGGGAGGCGAGGATGTGTCCGATTCTCCTGGAATCGTTGACTTGGAAAAACCA
GGGCGAATCTCCGCACCCAGCCCTGACTCCCCTGCCGCGGCCGCCCTCGGGTGTCCTCGCGCCCGAGATGCGGAGGAACT
GCGAGGAGCGGGGCTCTGGGCGGTTCCAGAACAGCTGCTACCCTTGGTGGGGTGGCTCCGGGGGAGGTATCGCAGCGGGG
TCTCTGGCGCAGTTGCATCTCCGTATTGAGTGCGAAGGGAGGTGCCCCTATTATTATTTGACACCCCCCTTGTATTTATG
GAGGGGTGTTAAAGCCCGCGGCTGAGCTCGCCACTCCAGCCGGCGAGAGAAAGAAGAAAAGCTGGCAAAAGGAGTGTTGG
ACGGGGGCGGTACTGGGGGTGGGGACGGGGGCGGTGGAGAGGGAAGGTTGGGAGGGGCTGCGGTGCCGGCGGGGGTAGGA
GAGCGGCTAGGGCGCGAGTGGGAACAGCCGCAGCGGAGGGGCCCCGGCGCGGAGCGGGGTTCACGCAGCCGCTAGCGCCC
AGGCGCCTCTCGCCTTCTCCTTCAGGTGGCGCAAAACTTTGTGCCTTGGATTTTGGCAAATTGTTTTCCTCACCGCCACC
TCCCGCGGCTTCTTAAGGGCGCCAGGGCCGATTTCGATTCCTCTGCCGCTGCGGGGCCGACTCCCGGGCTTTGCGCTCCG
GGCTCCCGGGGGAGCGGGGGCTCGGCGGGCACCAAGCCGCTGGTTCACTAAGTGCGTCTCCGAGATAGCAGGGGACTGTC
CAAAGGGGGTGAAAGGGTGCTCCCTTTATTCCCCCACCAAGACCACCCAGCCGCTTTAGGGGATAGCTCTGCAAGGGGAG
AGGTTCGGGACTGTGGCGCGCACTGCGCGCTGCGCCAGGTTTCCGCACCAAGACCCCTTTAACTCAAGACTGCCTCCCGC
TTTGTGTGCCCCGCTCCAGCAGCCTCCCGCGACGATGCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACT
ACGACTCGGTGCAGCCGTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCAGAGCGAGCTGCAGCCC
CCGGCGCCCAGCGAGGATATCTGGAAGAAATTCGAGCTGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCT
CTGCTCGCCCTCCTACGTTGCGGTCACACCCTTCTCCCTTCGGGGAGACAACGACGGCGGTGGCGGGAGCTTCTCCACGG
CCGACCAGCTGGAGATGGTGACCGAGCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCGACCCGGACGACGAG
ACCTTCATCAAAAACATCATCATCCAGGACTGTATGTGGAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCAGAGAAGCT
GGCCTCCTACCAGGCTGCGCGCAAAGACAGCGGCAGCCCGAACCCCGCCCGCGGCCACAGCGTCTGCTCCACCTCCAGCT
TGTACCTGCAGGATCTGAGCGCCGCCGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAACGACAGC
AGCTCGCCCAAGTCCTGCGCCTCGCAAGACTCCAGCGCCTTCTCTCCGTCCTCGGATTCTCTGCTCTCCTCGACGGAGTC
CTCCCCGCAGGGCAGCCCCGAGCCCCTGGTGCTCCATGAGGAGACACCGCCCACCACCAGCAGCGACTCTGGTAAGCGAA
GCCCGCCCAGGCCTGTCAAAAGTGGGCGGCTGGATACCTTTCCCATTTTCATTGGCAGCTTATTTAACGGGCCACTCTTA
TTAGGAAGGAGAGATAGCAGATCTGGAGAGATTTGGGAGCTCATCACCTCTGAAACCTTGGGCTTTAGCGTTTCCTCCCA
TCCCTTCCCCTTAGACTGCCCATGTTTGCAGCCCCCCTCCCCGTTTGTCTCCCACCCCTCAGGAATTTCATTTAGGTTTT
TAAACCTTCTGGCTTATCTTACAACTCAATCCACTTCTTCTTACCTCCCGTTAACATTTTAATTGCCCTGGGGCGGGGTG
GCAGGGAGTGTATGAATGAGGATAAGAGAGGATTGATCTCTGAGAGTGAATGAATTGCTTCCCTCTTAACTTCCGAGAAG
TGGTGGGATTTAATGAACTATCTACAAAAATGAGGGGCTGTGTTTAGAGGCTAGGCAGGGCCTGCCTGAGTGCGGGAGCC
AGTGAACTGCCTCAAGAGTGGGTGGGCTGAGGAGCTGGGATCTTCTCAGCCTATTTTGAACACTGAAAAGCAAATCCTTG
CCAAAGTTGGACTTTTTTTTTTCTTTTATTCCTTCCCCCGCCCTCTTGGACTTTTGGCAAAACTGCAATTTTTTTTTTTT
TATTTTTCATTTCCAGTAAAATAGGGAGTTGCTAAAGTCATACCAAGCAATTTGCAGCTATCATTTGCAACACCTGAAGT
GTTCTTGGTAAAGTCCCTCAAAAATAGGAGGTGCTTGGGAATGTGCTTTGCTTTGGGTGTGTCCAAAGCCTCATTAAGTC
TTAGGTAAGAATTGGCATCAATGTCCTATCCTGGGAAGTTGCACTTTTCTTGTCCATGCCATAACCCAGCTGTCTTTCCC
TTTATGAGACTCTTACCTTCATGGTGAGAGGAGTAAGGGTGGCTGGCTAGATTGGTTCTTTTTTTTTTTTTTTCCTTTTT
TAAGACGGAGTCTCACTCTGTCACTAGGCTGGAGTGCAGTGGCGCAATCAACCTCCAACCCCCTGGTTCAAGAGATTCTC
CTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCACACCACCATGCCAGGCTAATTTTTGTAATTTTAGTAGAGATG
GGGTTTCATCGTGTTGGCCAGGATGGTCTCTCCTGACCTCACGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTAC
AGGTGTGAGCCAGGGCACCAGGCTTAGATGTGGCTCTTTGGGGAGATAATTTTGTCCAGAGACCTTTCTAACGTATTCAT
GCCTTGTATTTGTACAGCATTAATCTGGTAATTGATTATTTTAATGTAACCTTGCTAAAGGAGTGATTTCTATTTCCTTT
CTTAAAGAGGAGGAACAAGAAGATGAGGAAGAAATCGATGTTGTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTC
AGAGTCTGGATCACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCCTCAAGAGGTGCCACGTCTCCA
CACATCAGCACAACTACGCAGCGCCTCCCTCCACTCGGAAGGACTATCCTGCTGCCAAGAGGGTCAAGTTGGACAGTGTC
AGAGTCCTGAGACAGATCAGCAACAACCGAAAATGCACCAGCCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCG
AACACACAACGTCTTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTGCGTGACCAGATCCCGGAGT
TGGAAAACAATGAAAAGGCCCCCAAGGTAGTTATCCTTAAAAAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGGAG
CAAAAGCTCATTTCTGAAGAGGACTTGTTGCGGAAACGACGAGAACAGTTGAAACACAAACTTGAACAGCTACGGAACTC
TTGTGCGTAAGGAAAAGTAAGGAAAACGATTCCTTCTAACAGAAATGTCCTGAGCAATCACCTATGAACTTGTTTCAAAT
GCATGATCAAATGCAACCTCACAACCTTGGCTGAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGCCTCAAATT
GGACTTTGGGCATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCTTTAACAGATTTGTATTTAAGAATTGTTTT
TAAAAAATTTTAAGATTTACACAATGTTTCTCTGTAAATATTGCCATTAAATGTAAATAACTTTAATAAAACGTTTATAG
CAGTTACACAGAATTTCAATCCTAGTATATAGTACCTAGTATTATAGGTACTATAAACCCTAATTTTTTTTATTTAAGTA
CATTTTGCTTTTTAAAGTTGATTTTTTTCTATTGTTTTTAGAAAAAATAAAATAACTGGCAAATATATCATTGAGCCAA
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Primary source |
RefSeq : NM_002467.3 (GI:71774082)
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Name |
V-myc myelocytomatosis viral oncogene homolog (avian) (MYC)
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
2377 nt
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Map |
8q24.21
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Location |
Chromosome 8 (NC_000008.10) strand : +
128748315...128748868 | 128750493...128751264 | 128752641...128753673 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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554
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554
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1
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Exon 2
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555
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1326
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772
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1
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Exon 3
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1327
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2359
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1033
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1
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ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
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Primary source |
NCBI : CCDS6359
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Nucleotide |
MYC, mRNA isoform 1[NM_002467.3] : 525...1889
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Length |
1365
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Location |
Chromosome 8 (NC_000008.10) strand : +
128748839...128748868 | 128750493...128751264 | 128752641...128753203 |
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Start codon |
1
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Translation |
NP_002458.2 |
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1 |
ACCCCCGAGC |
TGTGCTGCTC |
GCGGCCGCCA |
CCGCCGGGCC |
CCGGCCGTCC |
CTGGCTCCCC |
TCCTGCCTCG |
AGAAGGGCAG |
|
81 |
GGCTTCTCAG |
AGGCTTGGCG |
GGAAAAAGAA |
CGGAGGGAGG |
GATCGCGCTG |
AGTATAAAAG |
CCGGTTTTCG |
GGGCTTTATC |
|
161 |
TAACTCGCTG |
TAGTAATTCC |
AGCGAGAGGC |
AGAGGGAGCG |
AGCGGGCGGC |
CGGCTAGGGT |
GGAAGAGCCG |
GGCGAGCAGA |
|
241 |
GCTGCGCTGC |
GGGCGTCCTG |
GGAAGGGAGA |
TCCGGAGCGA |
ATAGGGGGCT |
TCGCCTCTGG |
CCCAGCCCTC |
CCGCTGATCC |
|
321 |
CCCAGCCAGC |
GGTCCGCAAC |
CCTTGCCGCA |
TCCACGAAAC |
TTTGCCCATA |
GCAGCGGGCG |
GGCACTTTGC |
ACTGGAACTT |
|
401 |
ACAACACCCG |
AGCAAGGACG |
CGACTCTCCC |
GACGCGGGGA |
GGCTATTCTG |
CCCATTTGGG |
GACACTTCCC |
CGCCGCTGCC |
|
481 |
AGGACCCGCT |
TCTCTGAAAG |
GCTCTCCTTG |
CAGCTGCTTA |
GACGCTGGAT |
TTTTTTCGGG |
TAGTGGAAAA |
CCAGCAGCCT |
|
561 |
CCCGCGACGA |
TGCCCCTCAA |
CGTTAGCTTC |
ACCAACAGGA |
ACTATGACCT |
CGACTACGAC |
TCGGTGCAGC |
CGTATTTCTA |
|
641 |
CTGCGACGAG |
GAGGAGAACT |
TCTACCAGCA |
GCAGCAGCAG |
AGCGAGCTGC |
AGCCCCCGGC |
GCCCAGCGAG |
GATATCTGGA |
|
721 |
AGAAATTCGA |
GCTGCTGCCC |
ACCCCGCCCC |
TGTCCCCTAG |
CCGCCGCTCC |
GGGCTCTGCT |
CGCCCTCCTA |
CGTTGCGGTC |
|
801 |
ACACCCTTCT |
CCCTTCGGGG |
AGACAACGAC |
GGCGGTGGCG |
GGAGCTTCTC |
CACGGCCGAC |
CAGCTGGAGA |
TGGTGACCGA |
|
881 |
GCTGCTGGGA |
GGAGACATGG |
TGAACCAGAG |
TTTCATCTGC |
GACCCGGACG |
ACGAGACCTT |
CATCAAAAAC |
ATCATCATCC |
|
961 |
AGGACTGTAT |
GTGGAGCGGC |
TTCTCGGCCG |
CCGCCAAGCT |
CGTCTCAGAG |
AAGCTGGCCT |
CCTACCAGGC |
TGCGCGCAAA |
|
1041 |
GACAGCGGCA |
GCCCGAACCC |
CGCCCGCGGC |
CACAGCGTCT |
GCTCCACCTC |
CAGCTTGTAC |
CTGCAGGATC |
TGAGCGCCGC |
|
1121 |
CGCCTCAGAG |
TGCATCGACC |
CCTCGGTGGT |
CTTCCCCTAC |
CCTCTCAACG |
ACAGCAGCTC |
GCCCAAGTCC |
TGCGCCTCGC |
|
1201 |
AAGACTCCAG |
CGCCTTCTCT |
CCGTCCTCGG |
ATTCTCTGCT |
CTCCTCGACG |
GAGTCCTCCC |
CGCAGGGCAG |
CCCCGAGCCC |
|
1281 |
CTGGTGCTCC |
ATGAGGAGAC |
ACCGCCCACC |
ACCAGCAGCG |
ACTCTGAGGA |
GGAACAAGAA |
GATGAGGAAG |
AAATCGATGT |
|
1361 |
TGTTTCTGTG |
GAAAAGAGGC |
AGGCTCCTGG |
CAAAAGGTCA |
GAGTCTGGAT |
CACCTTCTGC |
TGGAGGCCAC |
AGCAAACCTC |
|
1441 |
CTCACAGCCC |
ACTGGTCCTC |
AAGAGGTGCC |
ACGTCTCCAC |
ACATCAGCAC |
AACTACGCAG |
CGCCTCCCTC |
CACTCGGAAG |
|
1521 |
GACTATCCTG |
CTGCCAAGAG |
GGTCAAGTTG |
GACAGTGTCA |
GAGTCCTGAG |
ACAGATCAGC |
AACAACCGAA |
AATGCACCAG |
|
1601 |
CCCCAGGTCC |
TCGGACACCG |
AGGAGAATGT |
CAAGAGGCGA |
ACACACAACG |
TCTTGGAGCG |
CCAGAGGAGG |
AACGAGCTAA |
|
1681 |
AACGGAGCTT |
TTTTGCCCTG |
CGTGACCAGA |
TCCCGGAGTT |
GGAAAACAAT |
GAAAAGGCCC |
CCAAGGTAGT |
TATCCTTAAA |
|
1761 |
AAAGCCACAG |
CATACATCCT |
GTCCGTCCAA |
GCAGAGGAGC |
AAAAGCTCAT |
TTCTGAAGAG |
GACTTGTTGC |
GGAAACGACG |
|
1841 |
AGAACAGTTG |
AAACACAAAC |
TTGAACAGCT |
ACGGAACTCT |
TGTGCGTAAG |
GAAAAGTAAG |
GAAAACGATT |
CCTTCTAACA |
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1921 |
GAAATGTCCT |
GAGCAATCAC |
CTATGAACTT |
GTTTCAAATG |
CATGATCAAA |
TGCAACCTCA |
CAACCTTGGC |
TGAGTCTTGA |
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2001 |
GACTGAAAGA |
TTTAGCCATA |
ATGTAAACTG |
CCTCAAATTG |
GACTTTGGGC |
ATAAAAGAAC |
TTTTTTATGC |
TTACCATCTT |
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2081 |
TTTTTTTTCT |
TTAACAGATT |
TGTATTTAAG |
AATTGTTTTT |
AAAAAATTTT |
AAGATTTACA |
CAATGTTTCT |
CTGTAAATAT |
|
2161 |
TGCCATTAAA |
TGTAAATAAC |
TTTAATAAAA |
CGTTTATAGC |
AGTTACACAG |
AATTTCAATC |
CTAGTATATA |
GTACCTAGTA |
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2241 |
TTATAGGTAC |
TATAAACCCT |
AATTTTTTTT |
ATTTAAGTAC |
ATTTTGCTTT |
TTAAAGTTGA |
TTTTTTTCTA |
TTGTTTTTAG |
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2321 |
AAAAAATAAA |
ATAACTGGCA |
AATATATCAT |
TGAGCCAAAA |
AAAAAAAAAA |
AAAAAAA |
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>gi|71774082|ref|NM_002467.3|V-myc myelocytomatosis viral oncogene homolog (avian) (MYC)
ACCCCCGAGCTGTGCTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGTCCCTGGCTCCCCTCCTGCCTCGAGAAGGGCAG
GGCTTCTCAGAGGCTTGGCGGGAAAAAGAACGGAGGGAGGGATCGCGCTGAGTATAAAAGCCGGTTTTCGGGGCTTTATC
TAACTCGCTGTAGTAATTCCAGCGAGAGGCAGAGGGAGCGAGCGGGCGGCCGGCTAGGGTGGAAGAGCCGGGCGAGCAGA
GCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCGAATAGGGGGCTTCGCCTCTGGCCCAGCCCTCCCGCTGATCC
CCCAGCCAGCGGTCCGCAACCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACTTTGCACTGGAACTT
ACAACACCCGAGCAAGGACGCGACTCTCCCGACGCGGGGAGGCTATTCTGCCCATTTGGGGACACTTCCCCGCCGCTGCC
AGGACCCGCTTCTCTGAAAGGCTCTCCTTGCAGCTGCTTAGACGCTGGATTTTTTTCGGGTAGTGGAAAACCAGCAGCCT
CCCGCGACGATGCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCGGTGCAGCCGTATTTCTA
CTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCAGAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATATCTGGA
AGAAATTCGAGCTGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCTCTGCTCGCCCTCCTACGTTGCGGTC
ACACCCTTCTCCCTTCGGGGAGACAACGACGGCGGTGGCGGGAGCTTCTCCACGGCCGACCAGCTGGAGATGGTGACCGA
GCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCGACCCGGACGACGAGACCTTCATCAAAAACATCATCATCC
AGGACTGTATGTGGAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCAGAGAAGCTGGCCTCCTACCAGGCTGCGCGCAAA
GACAGCGGCAGCCCGAACCCCGCCCGCGGCCACAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGATCTGAGCGCCGC
CGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAACGACAGCAGCTCGCCCAAGTCCTGCGCCTCGC
AAGACTCCAGCGCCTTCTCTCCGTCCTCGGATTCTCTGCTCTCCTCGACGGAGTCCTCCCCGCAGGGCAGCCCCGAGCCC
CTGGTGCTCCATGAGGAGACACCGCCCACCACCAGCAGCGACTCTGAGGAGGAACAAGAAGATGAGGAAGAAATCGATGT
TGTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCTGGATCACCTTCTGCTGGAGGCCACAGCAAACCTC
CTCACAGCCCACTGGTCCTCAAGAGGTGCCACGTCTCCACACATCAGCACAACTACGCAGCGCCTCCCTCCACTCGGAAG
GACTATCCTGCTGCCAAGAGGGTCAAGTTGGACAGTGTCAGAGTCCTGAGACAGATCAGCAACAACCGAAAATGCACCAG
CCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCGAACACACAACGTCTTGGAGCGCCAGAGGAGGAACGAGCTAA
AACGGAGCTTTTTTGCCCTGCGTGACCAGATCCCGGAGTTGGAAAACAATGAAAAGGCCCCCAAGGTAGTTATCCTTAAA
AAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGGAGCAAAAGCTCATTTCTGAAGAGGACTTGTTGCGGAAACGACG
AGAACAGTTGAAACACAAACTTGAACAGCTACGGAACTCTTGTGCGTAAGGAAAAGTAAGGAAAACGATTCCTTCTAACA
GAAATGTCCTGAGCAATCACCTATGAACTTGTTTCAAATGCATGATCAAATGCAACCTCACAACCTTGGCTGAGTCTTGA
GACTGAAAGATTTAGCCATAATGTAAACTGCCTCAAATTGGACTTTGGGCATAAAAGAACTTTTTTATGCTTACCATCTT
TTTTTTTTCTTTAACAGATTTGTATTTAAGAATTGTTTTTAAAAAATTTTAAGATTTACACAATGTTTCTCTGTAAATAT
TGCCATTAAATGTAAATAACTTTAATAAAACGTTTATAGCAGTTACACAGAATTTCAATCCTAGTATATAGTACCTAGTA
TTATAGGTACTATAAACCCTAATTTTTTTTATTTAAGTACATTTTGCTTTTTAAAGTTGATTTTTTTCTATTGTTTTTAG
AAAAAATAAAATAACTGGCAAATATATCATTGAGCCAAAAAAAAAAAAAAAAAAAAA
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Exon number |
1
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Length |
554 nt
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Location |
Chromosome 8 (NC_000008.10) : 128748315...128748868 (+)
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Is part of |
MYC, mRNA isoform 1
(NM_002467.3)
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Sequence |
Show
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ACCCCCGAGCTGTGCTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGTCCCTGGCTCCCCTCCTGCCTCGAGAAGGGCAG
GGCTTCTCAGAGGCTTGGCGGGAAAAAGAACGGAGGGAGGGATCGCGCTGAGTATAAAAGCCGGTTTTCGGGGCTTTATC
TAACTCGCTGTAGTAATTCCAGCGAGAGGCAGAGGGAGCGAGCGGGCGGCCGGCTAGGGTGGAAGAGCCGGGCGAGCAGA
GCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCGAATAGGGGGCTTCGCCTCTGGCCCAGCCCTCCCGCTGATCC
CCCAGCCAGCGGTCCGCAACCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACTTTGCACTGGAACTT
ACAACACCCGAGCAAGGACGCGACTCTCCCGACGCGGGGAGGCTATTCTGCCCATTTGGGGACACTTCCCCGCCGCTGCC
AGGACCCGCTTCTCTGAAAGGCTCTCCTTGCAGCTGCTTAGACGCTGGATTTTTTTCGGGTAGTGGAAAACCAG
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Exon number |
2
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Length |
772 nt
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Location |
Chromosome 8 (NC_000008.10) : 128750493...128751264 (+)
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Is part of |
MYC, mRNA isoform 1
(NM_002467.3)
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Sequence |
Show
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CAGCCTCCCGCGACGATGCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCGGTGCAGCCGTA
TTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCAGAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATA
TCTGGAAGAAATTCGAGCTGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCTCTGCTCGCCCTCCTACGTT
GCGGTCACACCCTTCTCCCTTCGGGGAGACAACGACGGCGGTGGCGGGAGCTTCTCCACGGCCGACCAGCTGGAGATGGT
GACCGAGCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCGACCCGGACGACGAGACCTTCATCAAAAACATCA
TCATCCAGGACTGTATGTGGAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCAGAGAAGCTGGCCTCCTACCAGGCTGCG
CGCAAAGACAGCGGCAGCCCGAACCCCGCCCGCGGCCACAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGATCTGAG
CGCCGCCGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAACGACAGCAGCTCGCCCAAGTCCTGCG
CCTCGCAAGACTCCAGCGCCTTCTCTCCGTCCTCGGATTCTCTGCTCTCCTCGACGGAGTCCTCCCCGCAGGGCAGCCCC
GAGCCCCTGGTGCTCCATGAGGAGACACCGCCCACCACCAGCAGCGACTCTG
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Exon number |
3
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Length |
1033 nt
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Location |
Chromosome 8 (NC_000008.10) : 128752641...128753673 (+)
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Is part of |
MYC, mRNA isoform 1
(NM_002467.3)
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Sequence |
Show
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AGGAGGAACAAGAAGATGAGGAAGAAATCGATGTTGTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCT
GGATCACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCCTCAAGAGGTGCCACGTCTCCACACATCA
GCACAACTACGCAGCGCCTCCCTCCACTCGGAAGGACTATCCTGCTGCCAAGAGGGTCAAGTTGGACAGTGTCAGAGTCC
TGAGACAGATCAGCAACAACCGAAAATGCACCAGCCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCGAACACAC
AACGTCTTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTGCGTGACCAGATCCCGGAGTTGGAAAA
CAATGAAAAGGCCCCCAAGGTAGTTATCCTTAAAAAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGGAGCAAAAGC
TCATTTCTGAAGAGGACTTGTTGCGGAAACGACGAGAACAGTTGAAACACAAACTTGAACAGCTACGGAACTCTTGTGCG
TAAGGAAAAGTAAGGAAAACGATTCCTTCTAACAGAAATGTCCTGAGCAATCACCTATGAACTTGTTTCAAATGCATGAT
CAAATGCAACCTCACAACCTTGGCTGAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGCCTCAAATTGGACTTT
GGGCATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCTTTAACAGATTTGTATTTAAGAATTGTTTTTAAAAAA
TTTTAAGATTTACACAATGTTTCTCTGTAAATATTGCCATTAAATGTAAATAACTTTAATAAAACGTTTATAGCAGTTAC
ACAGAATTTCAATCCTAGTATATAGTACCTAGTATTATAGGTACTATAAACCCTAATTTTTTTTATTTAAGTACATTTTG
CTTTTTAAAGTTGATTTTTTTCTATTGTTTTTAGAAAAAATAAAATAACTGGCAAATATATCATTGAGCCAAA
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Primary source |
Uniprot : P01106
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Name |
Myc proto-oncogene protein
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Alternative name(s) |
Class E basic helix-loop-helix protein 39 Proto-oncogene c-Myc Transcription factor p64
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Synonym(s) |
bHLHe39
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Organism |
Homo sapiens
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Length |
439 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Disease
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Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.
Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
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Function
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Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
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Ptm
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Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus.
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Similarity
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Contains 1 basic helix-loop-helix (bHLH) domain.
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Subcellular location
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Nucleus, nucleoplasm. Nucleus, nucleolus.
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Subunit
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Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7.
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Biological process
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branching involved in ureteric bud morphogenesis [GO:0001658]
cellular iron ion homeostasis [GO:0006879]
cell cycle arrest [GO:0007050]
cell proliferation [GO:0008283]
regulation of telomere maintenance [GO:0032204]
response to drug [GO:0042493]
positive regulation of metanephric cap mesenchymal cell proliferation [GO:0090096]
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Molecular function
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transcription factor activity [GO:0003700]
transcription activator activity [GO:0016563]
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With
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Uniprot accession
|
IntAct
|
PSMA5
|
P28066
|
EBI-447544,EBI-355475
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MYO5C
|
Q9NQX4
|
EBI-447544,EBI-1237297
|
DNAJA2
|
O60884
|
EBI-447544,EBI-352957
|
PSMB1
|
P20618
|
EBI-447544,EBI-372273
|
TP53BP1
|
Q12888
|
EBI-447544,EBI-396540
|
SNIP1
|
Q8TAD8
|
EBI-447544,EBI-749336
|
GCN1L1
|
Q92616
|
EBI-447544,EBI-356221
|
IKBKAP
|
O95163
|
EBI-447544,EBI-347559
|
USP9X
|
Q93008
|
EBI-447544,EBI-302524
|
P4HA1
|
P13674
|
EBI-447544,EBI-1237386
|
PRPF6
|
O94906
|
EBI-447544,EBI-536755
|
MCM3
|
P25205
|
EBI-447544,EBI-355153
|
LAS1L
|
Q9Y4W2
|
EBI-447544,EBI-1051591
|
ACTL6A
|
O96019
|
EBI-447544,EBI-355018
|
XPO7
|
Q9UIA9
|
EBI-447544,EBI-286668
|
SP1
|
P08047
|
EBI-447544,EBI-298336
|
???
|
Q9UNJ2
|
EBI-447544,EBI-355398
|
FBXW7
|
Q969H0
|
EBI-447544,EBI-359574
|
CTPS
|
P17812
|
EBI-447544,EBI-1042983
|
IPO7
|
O95373
|
EBI-447544,EBI-286735
|
MTHFD1L
|
Q6UB35
|
EBI-447544,EBI-1046835
|
CCT5
|
P48643
|
EBI-447544,EBI-355710
|
DCLK1
|
O15075
|
EBI-447544,EBI-2684263
|
MAX
|
P61244
|
EBI-447544,EBI-878388
|
BTAF1
|
O14981
|
EBI-447544,EBI-1043840
|
???
|
Q13459
|
EBI-447544,EBI-721429
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DYNC1H1
|
Q14204
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EBI-447544,EBI-356015
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GIGYF2
|
Q6Y7W6
|
EBI-447544,EBI-765394
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ACACA
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Q13085
|
EBI-447544,EBI-717681
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PSMC1
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P62191
|
EBI-447544,EBI-357598
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EIF3E
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P60228
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EBI-447544,EBI-347740
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PSMD2
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Q13200
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EBI-447544,EBI-357648
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IRAK1
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P51617
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EBI-447544,EBI-358664
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EIF3I
|
Q13347
|
EBI-447544,EBI-354047
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FANCI
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Q9NVI1
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EBI-447544,EBI-1013291
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RUVBL2
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Q9Y230
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EBI-447544,EBI-352939
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ARHGEF2
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Q92974
|
EBI-447544,EBI-302405
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NDUFS2
|
O75306
|
EBI-447544,EBI-1224806
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EXOC4
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Q96A65
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EBI-447544,EBI-355383
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DDX52
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Q9Y2R4
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EBI-447544,EBI-395458
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LMNA
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P02545
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EBI-447544,EBI-351935
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EFTUD2
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Q15029
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EBI-447544,EBI-357897
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TUBG1
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P23258
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EBI-447544,EBI-302589
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AP2A1
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O95782
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EBI-447544,EBI-353552
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STAG2
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Q8N3U4
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EBI-447544,EBI-1057252
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SMARCAD1
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Q9H4L7
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EBI-447544,EBI-1056436
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SNRNP200
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O75643
|
EBI-447544,EBI-1045395
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NDUFA5
|
Q16718
|
EBI-447544,EBI-746417
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POLR2B
|
P30876
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EBI-447544,EBI-394712
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CSE1L
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P55060
|
EBI-447544,EBI-286709
|
DDX24
|
Q9GZR7
|
EBI-447544,EBI-713081
|
RFC1
|
P35251
|
EBI-447544,EBI-476616
|
SMC4
|
Q9NTJ3
|
EBI-447544,EBI-356173
|
CCT6A
|
P40227
|
EBI-447544,EBI-356687
|
HUWE1
|
Q7Z6Z7
|
EBI-447544,EBI-625934
|
CDC2
|
P06493
|
EBI-447544,EBI-444308
|
TTC27
|
Q6P3X3
|
EBI-447544,EBI-1057046
|
YWHAE
|
P62258
|
EBI-447544,EBI-356498
|
NUP205
|
Q92621
|
EBI-447544,EBI-1045046
|
SQSTM
|
Q13501
|
EBI-447544,EBI-307104
|
XRCC5
|
P13010
|
EBI-447544,EBI-357997
|
COPB2
|
P35606
|
EBI-447544,EBI-1056534
|
ARMC6
|
Q6NXE6
|
EBI-447544,EBI-1053802
|
FBXW8
|
Q8N3Y1
|
EBI-447544,EBI-914770
|
IRS4
|
O14654
|
EBI-447544,EBI-356594
|
PR15A
|
O75807
|
EBI-447544,EBI-714746
|
SMC1A
|
Q14683
|
EBI-447544,EBI-80690
|
???
|
Q99651
|
EBI-447544,EBI-1236857
|
NDUFA8
|
P51970
|
EBI-447544,EBI-1237250
|
GTF3C1
|
Q12789
|
EBI-447544,EBI-357956
|
ZNF281
|
Q9Y2X9
|
EBI-447544,EBI-396200
|
PSMD4
|
P55036
|
EBI-447544,EBI-359318
|
CHTF18
|
Q8WVB6
|
EBI-447544,EBI-1237523
|
SORBS1
|
Q9BX66
|
EBI-447544,EBI-433642
|
C1orf25
|
Q7Z2T5
|
EBI-447544,EBI-1237316
|
DCTN1
|
Q14203
|
EBI-447544,EBI-724352
|
HIST1H2BL
|
Q99880
|
EBI-447544,EBI-1237119
|
KPNB1
|
Q14974
|
EBI-447544,EBI-286758
|
HSPB1
|
P04792
|
EBI-447544,EBI-352682
|
IGF2BP1
|
Q9NZI8
|
EBI-447544,EBI-1053892
|
PSMA1
|
P25786
|
EBI-447544,EBI-359352
|
CEP57
|
Q86XR8
|
EBI-447544,EBI-308614
|
ABCB7
|
O75027
|
EBI-447544,EBI-1236950
|
IDH3B
|
O43837
|
EBI-447544,EBI-725377
|
HIGD1A
|
Q9Y241
|
EBI-447544,EBI-1051940
|
RAF1
|
P04049
|
EBI-447544,EBI-365996
|
XPO1
|
O14980
|
EBI-447544,EBI-355867
|
PPP6C
|
O00743
|
EBI-447544,EBI-359751
|
CCT4
|
P50991
|
EBI-447544,EBI-356876
|
TMPO
|
P42166
|
EBI-447544,EBI-395393
|
RPP30
|
P78346
|
EBI-447544,EBI-366553
|
DPM1
|
O60762
|
EBI-447544,EBI-719526
|
PSMC4
|
P43686
|
EBI-447544,EBI-743997
|
YWHAB
|
P31946
|
EBI-447544,EBI-359815
|
RPN1
|
P04843
|
EBI-447544,EBI-355963
|
SR140
|
O15042
|
EBI-447544,EBI-310697
|
CHD4
|
Q14839
|
EBI-447544,EBI-372916
|
GTF2I
|
P78347
|
EBI-447544,EBI-359622
|
HADHB
|
P55084
|
EBI-447544,EBI-356635
|
CHD5
|
Q8TDI0
|
EBI-447544,EBI-1042816
|
LBR
|
Q14739
|
EBI-447544,EBI-1055147
|
HDAC1
|
Q13547
|
EBI-447544,EBI-301834
|
DNAJA3
|
Q96EY1
|
EBI-447544,EBI-356767
|
PDCD11
|
Q14690
|
EBI-447544,EBI-300028
|
KIAA1967
|
Q8N163
|
EBI-447544,EBI-355410
|
C1QBP
|
Q07021
|
EBI-447544,EBI-347528
|
NUP93
|
Q8N1F7
|
EBI-447544,EBI-1042703
|
XPO5
|
Q9HAV4
|
EBI-447544,EBI-517949
|
SLC25A12
|
O75746
|
EBI-447544,EBI-1047585
|
NUP153
|
P49790
|
EBI-447544,EBI-286779
|
DDX1
|
Q92499
|
EBI-447544,EBI-358474
|
SPTLC1
|
O15269
|
EBI-447544,EBI-1044323
|
XRCC6
|
P12956
|
EBI-447544,EBI-353208
|
UBTF
|
P17480
|
EBI-447544,EBI-396235
|
TNPO3
|
Q9Y5L0
|
EBI-447544,EBI-1042571
|
LONP1
|
P36776
|
EBI-447544,EBI-1054513
|
PSMA4
|
P25789
|
EBI-447544,EBI-359310
|
PPT1
|
P50897
|
EBI-447544,EBI-1237011
|
CEPT1
|
Q9Y6K0
|
EBI-447544,EBI-1237183
|
PGAP1
|
Q75T13
|
EBI-447544,EBI-1055128
|
GCDH
|
Q92947
|
EBI-447544,EBI-1236978
|
PSMA3
|
P25788
|
EBI-447544,EBI-348380
|
EXOC1
|
Q9NV70
|
EBI-447544,EBI-1045313
|
PSMB4
|
P28070
|
EBI-447544,EBI-603350
|
RANBP2
|
P49792
|
EBI-447544,EBI-973138
|
MOGS
|
Q13724
|
EBI-447544,EBI-720141
|
ERCC3
|
P19447
|
EBI-447544,EBI-1183307
|
KPNA2
|
P52292
|
EBI-447544,EBI-349938
|
MSH3
|
P20585
|
EBI-447544,EBI-1164205
|
EXOC3
|
O60645
|
EBI-447544,EBI-1052278
|
SMARCC1
|
Q92922
|
EBI-447544,EBI-355653
|
IQGAP3
|
Q86VI3
|
EBI-447544,EBI-1237354
|
GTF3C2
|
Q8WUA4
|
EBI-447544,EBI-1237062
|
OAT
|
P04181
|
EBI-447544,EBI-721662
|
PSMD3
|
O43242
|
EBI-447544,EBI-357622
|
SKIV2L
|
Q15477
|
EBI-447544,EBI-373226
|
OPA1
|
O60313
|
EBI-447544,EBI-1054131
|
PLK1
|
P53350
|
EBI-447544,EBI-476768
|
DNAJB6
|
O75190
|
EBI-447544,EBI-1053164
|
PTPN14
|
Q15678
|
EBI-447544,EBI-1237156
|
NCL
|
P19338
|
EBI-447544,EBI-346967
|
COPG
|
Q9Y678
|
EBI-447544,EBI-1049127
|
SCD
|
O00767
|
EBI-447544,EBI-2684237
|
SEC61A1
|
P61619
|
EBI-447544,EBI-358919
|
SLC25A11
|
Q02978
|
EBI-447544,EBI-359174
|
NEK9
|
Q8TD19
|
EBI-447544,EBI-1044009
|
SNRNP70
|
P08621
|
EBI-447544,EBI-1049228
|
PCBP1
|
Q15365
|
EBI-447544,EBI-946095
|
SLC25A1
|
P53007
|
EBI-447544,EBI-359163
|
SMARCC2
|
Q8TAQ2
|
EBI-447544,EBI-357418
|
SUCLG1
|
P53597
|
EBI-447544,EBI-1237145
|
ATP5C1
|
P36542
|
EBI-447544,EBI-711768
|
HELLS
|
Q9NRZ9
|
EBI-447544,EBI-1056215
|
WDR5
|
P61964
|
EBI-447544,EBI-540834
|
ALDH18A1
|
P54886
|
EBI-447544,EBI-1210304
|
MRPS34
|
P82930
|
EBI-447544,EBI-1048516
|
CYR61
|
O00622
|
EBI-447544,EBI-1237454
|
SKP2
|
Q13309
|
EBI-447544,EBI-456291
|
AP3D1
|
O14617
|
EBI-447544,EBI-1051639
|
LRPPRC
|
P42704
|
EBI-447544,EBI-1050853
|
TUBA4A
|
P68366
|
EBI-447544,EBI-351772
|
HNRNPA0
|
Q13151
|
EBI-447544,EBI-724092
|
NCAPG2
|
Q86XI2
|
EBI-447544,EBI-1047404
|
UST
|
Q9Y2C2
|
EBI-447544,EBI-2692574
|
CCT8
|
P50990
|
EBI-447544,EBI-356507
|
MAGED2
|
Q9UNF1
|
EBI-447544,EBI-725832
|
RFC2
|
P35250
|
EBI-447544,EBI-476409
|
XPOT
|
O43592
|
EBI-447544,EBI-286683
|
ARCN1
|
P48444
|
EBI-447544,EBI-1044491
|
HEATR1
|
Q9H583
|
EBI-447544,EBI-1048716
|
PLOD3
|
O60568
|
EBI-447544,EBI-741582
|
IDH3G
|
P51553
|
EBI-447544,EBI-1210876
|
HNRNPK
|
P61978
|
EBI-447544,EBI-304185
|
KIAA1524
|
Q8TCG1
|
EBI-447544,EBI-1379376
|
PDS5B
|
Q9NTI5
|
EBI-447544,EBI-1175604
|
METTL13
|
Q8N6R0
|
EBI-447544,EBI-1053295
|
POLR2A
|
P24928
|
EBI-447544,EBI-295301
|
HSPD1
|
P10809
|
EBI-447544,EBI-352528
|
MYBBP1A
|
Q9BQG0
|
EBI-447544,EBI-676973
|
PELO
|
Q9BRX2
|
EBI-447544,EBI-1043580
|
DDX3X
|
O00571
|
EBI-447544,EBI-353779
|
ALDH1B1
|
P30837
|
EBI-447544,EBI-1237410
|
DIAPH3
|
Q9NSV4
|
EBI-447544,EBI-1050601
|
TRIM28
|
Q13263
|
EBI-447544,EBI-78139
|
RFC3
|
P40938
|
EBI-447544,EBI-1055010
|
PSMA2
|
P25787
|
EBI-447544,EBI-603262
|
KLHL5
|
Q96PQ7
|
EBI-447544,EBI-2692595
|
SQRDL
|
Q9Y6N5
|
EBI-447544,EBI-1170418
|
- (xeno)
|
P03070
|
EBI-447544,EBI-617698
|
PSMC6
|
P62333
|
EBI-447544,EBI-357669
|
PRKDC
|
P78527
|
EBI-447544,EBI-352053
|
TUBGCP2
|
Q9BSJ2
|
EBI-447544,EBI-357881
|
IPO13
|
O94829
|
EBI-447544,EBI-747310
|
PSMA7
|
O14818
|
EBI-447544,EBI-603272
|
ATP1A1
|
P05023
|
EBI-447544,EBI-358778
|
YWHAQ
|
P27348
|
EBI-447544,EBI-359854
|
EIF4A1
|
P60842
|
EBI-447544,EBI-73449
|
CEBPZ
|
Q03701
|
EBI-447544,EBI-1046778
|
ATP5J2
|
P56134
|
EBI-447544,EBI-712794
|
PDS5A
|
Q29RF7
|
EBI-447544,EBI-1175454
|
POLD1
|
P28340
|
EBI-447544,EBI-716569
|
IPO4
|
Q8TEX9
|
EBI-447544,EBI-395967
|
MDN1
|
Q9NU22
|
EBI-447544,EBI-1050480
|
ASS1
|
P00966
|
EBI-447544,EBI-536842
|
EEF1G
|
P26641
|
EBI-447544,EBI-351467
|
ZNF121
|
P58317
|
EBI-447544,EBI-1228269
|
FASTKD2
|
Q9NYY8
|
EBI-447544,EBI-1055752
|
KPNA4
|
O00629
|
EBI-447544,EBI-396343
|
MYO5A
|
Q9Y4I1
|
EBI-447544,EBI-1054086
|
ARL1
|
P40616
|
EBI-447544,EBI-1052746
|
TCP1
|
P17987
|
EBI-447544,EBI-356553
|
AKAP8
|
O43823
|
EBI-447544,EBI-1237481
|
COPG2
|
Q9UBF2
|
EBI-447544,EBI-1045840
|
EP400
|
Q96L91
|
EBI-447544,EBI-399163
|
IDH3A
|
P50213
|
EBI-447544,EBI-355999
|
POLE
|
Q07864
|
EBI-447544,EBI-348526
|
PIAS2
|
O75928
|
EBI-447544,EBI-348555
|
UBE3C
|
Q15386
|
EBI-447544,EBI-1058871
|
MYO1B
|
O43795
|
EBI-447544,EBI-351119
|
TOP1
|
P11387
|
EBI-447544,EBI-876302
|
FANCD2
|
Q9BXW9
|
EBI-447544,EBI-359343
|
BCR
|
P11274
|
EBI-447544,EBI-712838
|
UBR2
|
Q8IWV8
|
EBI-447544,EBI-1237260
|
SARS
|
P49591
|
EBI-447544,EBI-1053431
|
AASS
|
Q9UDR5
|
EBI-447544,EBI-1237169
|
MARS
|
P56192
|
EBI-447544,EBI-355848
|
PTGES2
|
Q9H7Z7
|
EBI-447544,EBI-681645
|
GANAB
|
Q14697
|
EBI-447544,EBI-348004
|
SMARCA4
|
P51532
|
EBI-447544,EBI-302489
|
IGF2BP2
|
Q9Y6M1
|
EBI-447544,EBI-1024419
|
SSR4
|
P51571
|
EBI-447544,EBI-1054539
|
MKLN1
|
Q9UL63
|
EBI-447544,EBI-1048053
|
SHOC2
|
Q9UQ13
|
EBI-447544,EBI-993879
|
???
|
Q9DH70
|
EBI-447544,EBI-1249719
|
UTP15
|
Q8TED0
|
EBI-447544,EBI-1048301
|
EP300
|
Q09472
|
EBI-447544,EBI-447295
|
ARF4
|
P18085
|
EBI-447544,EBI-1237085
|
TRRAP
|
Q9Y4A5
|
EBI-447544,EBI-399128
|
NUP188
|
Q5SRE5
|
EBI-447544,EBI-1049404
|
ATP6V1H
|
Q9UI12
|
EBI-447544,EBI-724719
|
FBL
|
P22087
|
EBI-447544,EBI-358318
|
IPO9
|
Q96P70
|
EBI-447544,EBI-356319
|
MATR3
|
P43243
|
EBI-447544,EBI-352602
|
GTF3C3
|
Q9Y5Q9
|
EBI-447544,EBI-1054873
|
IPO11
|
Q9UI26
|
EBI-447544,EBI-748752
|
HEATR3
|
Q7Z4Q2
|
EBI-447544,EBI-1051903
|
MSH6
|
P52701
|
EBI-447544,EBI-395529
|
DDX20
|
Q9UHI6
|
EBI-447544,EBI-347658
|
TMEM33
|
P57088
|
EBI-447544,EBI-1048629
|
MRPS22
|
P82650
|
EBI-447544,EBI-1050752
|
DIMT1L
|
Q9UNQ2
|
EBI-447544,EBI-395738
|
MSH2
|
P43246
|
EBI-447544,EBI-355888
|
HSPH1
|
Q92598
|
EBI-447544,EBI-356829
|
GSG2
|
Q8TF76
|
EBI-447544,EBI-1237328
|
RPN2
|
P04844
|
EBI-447544,EBI-719731
|
CCT3
|
P49368
|
EBI-447544,EBI-356673
|
BRD3
|
Q15059
|
EBI-447544,EBI-1383460
|
AKAP8L
|
Q9ULX6
|
EBI-447544,EBI-357530
|
PSMC3
|
P17980
|
EBI-447544,EBI-359720
|
NUP133
|
Q8WUM0
|
EBI-447544,EBI-295695
|
RFC5
|
P40937
|
EBI-447544,EBI-712376
|
ZBTB17
|
Q13105
|
EBI-447544,EBI-372156
|
SMC2
|
O95347
|
EBI-447544,EBI-355822
|
DHX15
|
O43143
|
EBI-447544,EBI-1237044
|
???
|
P57678
|
EBI-447544,EBI-356700
|
PSMB3
|
P49720
|
EBI-447544,EBI-603340
|
NOL9
|
Q5SY16
|
EBI-447544,EBI-1055462
|
HDAC2
|
Q92769
|
EBI-447544,EBI-301821
|
NDUFS3
|
O75489
|
EBI-447544,EBI-1224896
|
SLIT2
|
O94813
|
EBI-447544,EBI-1236865
|
MAPKAP1
|
Q9BPZ7
|
EBI-447544,EBI-749938
|
NMI
|
Q13287
|
EBI-447544,EBI-372942
|
WDR77
|
Q9BQA1
|
EBI-447544,EBI-1237307
|
Max (xeno)
|
P52164
|
EBI-447544,EBI-1184963
|
PSME4
|
Q14997
|
EBI-447544,EBI-1236916
|
TUBGCP4
|
Q9UGJ1
|
EBI-447544,EBI-1052544
|
ETFA
|
P13804
|
EBI-447544,EBI-1052886
|
ATP2A2
|
P16615
|
EBI-447544,EBI-358933
|
MMS19
|
Q96T76
|
EBI-447544,EBI-1044169
|
NOP56
|
O00567
|
EBI-447544,EBI-396034
|
PSMB5
|
P28074
|
EBI-447544,EBI-357828
|
RNH1
|
P13489
|
EBI-447544,EBI-1237106
|
CCT2
|
P78371
|
EBI-447544,EBI-357407
|
RUVBL1
|
Q9Y265
|
EBI-447544,EBI-353675
|
SMARCA5
|
O60264
|
EBI-447544,EBI-352588
|
ECT2
|
Q9H8V3
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EBI-447544,EBI-1054039
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SKP1
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P63208
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EBI-447544,EBI-307486
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IQGAP1
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P46940
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EBI-447544,EBI-297509
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HNRNPC
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P07910
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EBI-447544,EBI-357966
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IQGAP2
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Q13576
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EBI-447544,EBI-357571
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PPP1CA
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P62136
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EBI-447544,EBI-357253
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PRPF8
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Q6P2Q9
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EBI-447544,EBI-538479
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SLC25A13
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Q9UJS0
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EBI-447544,EBI-1222503
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NDUFS1
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P28331
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EBI-447544,EBI-1043922
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RNGTT
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O60942
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EBI-447544,EBI-1237132
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vIRF-3 (xeno)
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Q9DUN1
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EBI-447544,EBI-1647907
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TOP2A
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P11388
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EBI-447544,EBI-539628
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PSMC2
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P35998
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EBI-447544,EBI-359710
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HNRNPF
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P52597
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EBI-447544,EBI-352986
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ACOT8
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O14734
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EBI-447544,EBI-1237371
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NONO
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Q15233
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EBI-447544,EBI-350527
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UNC45A
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Q9H3U1
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EBI-447544,EBI-1048763
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MAP7D1
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Q3KQU3
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EBI-447544,EBI-713229
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MCM7
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P33993
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EBI-447544,EBI-355924
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GTF3C4
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Q9UKN8
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EBI-447544,EBI-1237240
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XRN1
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Q8IZH2
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EBI-447544,EBI-372406
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DHX37
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Q8IY37
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EBI-447544,EBI-308285
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EIF4ENIF1
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Q9NRA8
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EBI-447544,EBI-301024
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Alternative product(s)
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top
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Uniprot Identifier
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Difference(s) with the 'canonical' sequence
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Notes
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Sequences
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Isoform 1
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P01106-1
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---
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'Canonical' sequence
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Get Fasta
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Isoform 2
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P01106-2
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1-1 : M -> MDFFRVVENQQPPATM
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---
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Get Fasta
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Feature key |
Position
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Length
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Description
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Feature identifier
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Region |
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Compositional bias
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33 - 37
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5
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Poly-Gln
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P01106-COMPBIAS-33
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Compositional bias
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88 - 91
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4
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Poly-Gly
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P01106-COMPBIAS-88
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Dna binding
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354 - 367
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14
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Basic motif
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P01106-DNA_BIND-354
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Domain
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368 - 407
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40
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Helix-loop-helix motif
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P01106-DOMAIN-368
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Domain
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413 - 434
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22
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Leucine-zipper
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P01106-DOMAIN-413
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Natural variations |
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Natural variant site
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11 - 11
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1
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N -> S (in dbSNP:rs4645959)
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VAR_016327
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Natural variant site
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39 - 39
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1
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E -> D (in a Burkitt lymphoma symple)
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VAR_063384
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Natural variant site
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57 - 57
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1
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P -> S (in a Burkitt lymphoma sample)
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VAR_063385
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Natural variant site
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59 - 59
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1
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P -> A (in a Burkitt lymphoma sample)
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VAR_063386
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Natural variant site
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86 - 86
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1
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N -> T (in a Burkitt lymphoma sample)
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VAR_063387
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Natural variant site
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160 - 160
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1
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G -> C (in dbSNP:rs4645960)
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VAR_016328
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Natural variant site
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170 - 170
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1
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V -> I (in dbSNP:rs4645961)
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VAR_016329
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Natural variant site
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322 - 322
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1
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A -> V (in dbSNP:rs4645968)
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VAR_016330
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Alternative sequence
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1 - 1
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1
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M -> MDFFRVVENQQPPATM
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VSP_037813
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Amino acid modifications |
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Glycosylation
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58 - 58
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1
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O-linked (GlcNAc); alternate
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P01106-CARBOHYD-58
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Modified residue
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6 - 6
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1
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Phosphoserine
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P01106-MOD_RES-6
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Modified residue
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8 - 8
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1
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Phosphothreonine; by RAF; in vitro
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P01106-MOD_RES-8
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Modified residue
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58 - 58
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1
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Phosphothreonine; by GSK3; alternate
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P01106-MOD_RES-58
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Modified residue
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62 - 62
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1
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Phosphoserine; by GSK3
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P01106-MOD_RES-62
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Modified residue
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71 - 71
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1
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Phosphoserine
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P01106-MOD_RES-71
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Modified residue
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143 - 143
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1
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N6-acetyllysine; by PCAF
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P01106-MOD_RES-143
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Modified residue
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148 - 148
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1
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N6-acetyllysine
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P01106-MOD_RES-148
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Modified residue
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157 - 157
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1
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N6-acetyllysine; by PCAF
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P01106-MOD_RES-157
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Modified residue
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275 - 275
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1
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N6-acetyllysine; by PCAF
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P01106-MOD_RES-275
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Modified residue
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317 - 317
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1
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N6-acetyllysine; by PCAF
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P01106-MOD_RES-317
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Modified residue
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323 - 323
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1
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N6-acetyllysine; by PCAF
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P01106-MOD_RES-323
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Modified residue
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344 - 344
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1
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Phosphoserine
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P01106-MOD_RES-344
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Modified residue
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348 - 348
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1
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Phosphoserine
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P01106-MOD_RES-348
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Modified residue
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371 - 371
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1
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N6-acetyllysine; by PCAF
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P01106-MOD_RES-371
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Experimental info |
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Mutagenesis
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58 - 58
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1
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T->A: Impairs interaction with FBXW7 and subsequent degradation by the proteasome
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P01106-MUTAGEN-58
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Mutagenesis
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62 - 62
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1
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S->A: Impairs interaction with FBXW7 and subsequent degradation by the proteasome
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P01106-MUTAGEN-62
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1 |
MPLNVSFTNR |
NYDLDYDSVQ |
PYFYCDEEEN |
FYQQQQQSEL |
QPPAPSEDIW |
KKFELLPTPP |
LSPSRRSGLC |
SPSYVAVTPF |
|
81 |
SLRGDNDGGG |
GSFSTADQLE |
MVTELLGGDM |
VNQSFICDPD |
DETFIKNIII |
QDCMWSGFSA |
AAKLVSEKLA |
SYQAARKDSG |
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161 |
SPNPARGHSV |
CSTSSLYLQD |
LSAAASECID |
PSVVFPYPLN |
DSSSPKSCAS |
QDSSAFSPSS |
DSLLSSTESS |
PQGSPEPLVL |
|
241 |
HEETPPTTSS |
DSEEEQEDEE |
EIDVVSVEKR |
QAPGKRSESG |
SPSAGGHSKP |
PHSPLVLKRC |
HVSTHQHNYA |
APPSTRKDYP |
|
321 |
AAKRVKLDSV |
RVLRQISNNR |
KCTSPRSSDT |
EENVKRRTHN |
VLERQRRNEL |
KRSFFALRDQ |
IPELENNEKA |
PKVVILKKAT |
|
401 |
AYILSVQAEE |
QKLISEEDLL |
RKRREQLKHK |
LEQLRNSCA |
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>sp|P01106|MYC_human Myc proto-oncogene protein
MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPF
SLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSG
SPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL
HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYP
AAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKAT
AYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
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