(MAP2K7) mitogen-activated protein kinase kinase 7 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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10044
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Official symbol
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MAP2K7
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Official name
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mitogen-activated protein kinase kinase 7
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 19 (NC_000019.9) : 7968764...7979362 (+)
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Map
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19p13.3-p13.2
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Length
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10599 nt
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NM_145185.2
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MAP2K7, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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O14733
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Dual specificity mitogen-activated protein kinase kinase 7
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Homo sapiens
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419 aa
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Synonyms |
MAPKK7; PRKMK7; MKK7; Jnkk2
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Alternative name(s) |
JNK kinase 2; JNK-activating kinase 2; MAP kinase kinase 7; c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7
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Summary |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl
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1 |
TGCGGTGTTT |
GTCTGCCGGA |
CTGACGGGCG |
GCCGGGCGGT |
GCGCGGCGGC |
GGTGGCGGCG |
GGGAAGATGG |
CGGCGTCCTC |
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81 |
CCTGGAACAG |
AAGCTGTCCC |
GCCTGGAAGC |
AAAGCTGAAG |
CAGGAGAACC |
GGGAGGCCCG |
GCGGAGGATC |
GACCTCAACC |
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161 |
TGGATATCAG |
CCCCCAGCGG |
CCCAGGCCCA |
GTAAGCACGG |
CGGCGTGGGG |
GAGGGGGCGG |
GCGGGCGGGG |
CGGGGCGCGC |
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241 |
GCCGCGGGAG |
GCCCCGCCCC |
CACCACAAGG |
CCCCGCCCCC |
GCTTCCGGGG |
CGCTCGCTCT |
CCTCTCCGCC |
CCCCCCGCTG |
|
321 |
CGGGCTCGCG |
GGGCGAGGGT |
CACGGTGACC |
CGGGGGGCGT |
GGAGCCGGCG |
AGCTCCGGGG |
GGTTCGCACC |
CTCAGGGCTT |
|
401 |
GGGAGCCCAG |
TTCCCGGACC |
CAGGCGAGGC |
CCCCAGCTGA |
TGACCCGCCC |
CCATCGCCGT |
GATCCTCTGG |
GTCGGGCTTC |
|
481 |
CCCGACTCCA |
CGCGACAGTG |
ACCACATCCA |
GGTCGCCCCG |
AAAACACAGA |
CACGTCCCTG |
TTGACCTGAT |
GCTACCACTC |
|
561 |
TCGTCATCTC |
AGGGACTGTC |
TGGCGCCCCC |
CTCCCCCGGC |
CTGGGGGCTT |
GTCAGCCCCG |
TGCAGCGACG |
ATCTACGCAC |
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641 |
ACGCGCACGC |
CTGGCTCGGG |
GACACCTGAG |
GTTACTTGAC |
CACATAGAGC |
CCCTCCCCAT |
CTCTTCTGAC |
CCGAGGATTC |
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721 |
TCCCTCTCGC |
TCTCCCTGTG |
ACCGTGTCTG |
AGGTGGGGGG |
ACGGGAGGGG |
GTCCCTTCTC |
CCCCTCTTGG |
CGACAGTGAC |
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801 |
CATGGCATTG |
GGCTCAGCAG |
ACCCCCTCCC |
ACATACACCA |
GGCCCCGCAA |
ATCCCTGTGA |
CCAGTTTCAC |
TGCCACCATC |
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881 |
TTGGTGAGCG |
TGTGGTGTCT |
GACCTCCAGA |
AATGCACATC |
GACCCCCAGC |
CAGCCCGGTG |
ACTTTGTCAC |
CTGTGTTCAA |
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961 |
GTGATGGCTC |
CCCTTCCCTT |
CACACCCACA |
CCCACCTGAC |
CTGGGGACAC |
CTGGGGCCAG |
TGTGACTCTA |
GGCCTGCTCC |
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1041 |
CGCCGCGCCC |
CAGCATACAT |
CCACCTGCTT |
TCTGATCAGT |
CCCACCACCT |
CGGTACCTAC |
CTCCCTGACA |
CCTTGTCATC |
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1121 |
CTAGATCAGT |
ACCTCTCGCT |
TCACACACAC |
CTGGCCTGGG |
AACACTGACC |
ATATCTAGTC |
TCCCGGCTTT |
TTCCCCAAGA |
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1201 |
TCCTGGTCTC |
TAAATCCTCT |
GGGCTGGAGG |
AAATTAGATT |
TTCAAACCCT |
GTGAACACCA |
CCCCTGACCC |
ATGATCCTTT |
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1281 |
TTGTGTCTTT |
CTTGACCCAG |
TAAAATTCTC |
TCTTGTCTCC |
TCTGATGTGA |
CCTTCGTAGT |
TTATTTAGTT |
CTCTCTATGG |
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1361 |
AGTCATTATG |
GCAGGCGAGA |
AAGGTACCCC |
CGTATCTGGG |
CACCCCACCC |
ATTCCCTGGT |
CACCCAGCCT |
GACCTTCACA |
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1441 |
GCCTGACACC |
CTCCTGTCCC |
TCCCTCTCCT |
GACCTGAGTC |
AGCGTGGGTT |
CCTCCTTGGG |
GAGTCTCTTG |
GGGGTCCAGA |
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1521 |
GAAATCATGG |
AGGTGGGGAT |
TCTGGTGCAG |
GACACTGCCT |
GAGACAAGAA |
GCCCAGCCAA |
GACACGGGTC |
CCTGCTAGCC |
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1601 |
CCTGGGGGCC |
GCCCTCCCTG |
GCCCCTGAGT |
GGATGAGACA |
GGGTTGAGTC |
CAGGATCCCG |
GGTGCCTTCA |
GGGGTGGCCG |
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1681 |
TTCCCATGCA |
GAGCTAGGAG |
GCCGGTGGCA |
GGCAGGCCCC |
CGAGGAGTCC |
CCTCCAGGCG |
TCTCTGTCTG |
TGTCAACTCC |
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1761 |
ATCCCATCCT |
CCCCGCCCTC |
CCCATCTCTG |
TCGGTTCCTA |
GCCATCTCTG |
CAGTTCGGTG |
CCTCCCCCTC |
CTCCTCGTTT |
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1841 |
ATGATTTGAT |
TTCTTTTCTT |
TTGGACGAAT |
CAGTCGTTTC |
TGTTGTGATT |
TATCGTGGTG |
TTGTTTTTTT |
CTTCCTTTTC |
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1921 |
CCCATCCAGT |
TATTGTGATC |
ACTCTAAGCC |
CTGCTCCTGC |
CCCGTCCCAA |
CGAGCAGGTA |
CCAGCCTTTT |
TATCATCGCT |
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2001 |
GCTTGGACAT |
CTGCACCATT |
GACCTAACCG |
CTGCCCCGGC |
CGCAGAATGG |
CGTCCCCCAG |
CCCCCATGCT |
CTGTGTGTGT |
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2081 |
CCCCATGTCC |
CTTCCCCTCA |
CTCTCACTTT |
CTCTCTCACT |
CCACTCAAGC |
AGCGGTCAGC |
CCAGCCCAGC |
CTCCTCTGCG |
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2161 |
TCCTCCCTCC |
TCCTCCCCCT |
CCCTTACTCC |
CAGCTCCACT |
TTGGACTCCC |
TGGAGGAGGA |
GGTGGGCTCC |
CCCACTGAAT |
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2241 |
GGGAGTCTGT |
GGCCTCCGGG |
GGTGGGGGGG |
GTGCACGCCT |
GTGTGTGTGT |
AACTGAGAGA |
ACGAGAAAGT |
TGGGCCTGGT |
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2321 |
GGGTGGGTGG |
CCTGTGCCTA |
TGGATCTCTC |
TCAACAACTA |
GGTGAACACA |
TAGCACCCCC |
CGGGTTCCAT |
ACCAGCCCTG |
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2401 |
GGCGCCAGGG |
ACACAGCAGT |
GAATAGAACA |
GATGGAGCCC |
CTCTCCTCTG |
TAGCGGGGGG |
CTGCAATAGG |
GGGGCCCACT |
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2481 |
GGACAAGGAG |
CACATTCCCA |
CCAGAGAGAA |
CATTCTAGCT |
GGGTGAGCGG |
CCCTGCAGGG |
GGCCAGCCTG |
GGGGAACCTC |
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2561 |
TGGAGACGGT |
GGGAATTGAA |
CAAAGCCTCT |
GGGGAGGCCA |
GGCACGGTGG |
CTCACACCTG |
TGATCCCAAC |
ACTCGGGGAG |
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2641 |
GTTGAGGCTA |
CAGGGAGCCA |
TGATCACACC |
ACTGCACCCC |
AGCCTGGGTG |
ACAGCGAGAT |
CCTGTCTCAA |
AAATTTAAAA |
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2721 |
ACTGGGCCAG |
GCGCAGTGGC |
TCATGCCTGT |
AATTTCAGTA |
CTTTGGGAGG |
CCAAGGAGGG |
TGGATCACTT |
GAGGTCAGGA |
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2801 |
GTTCGAGACC |
AGCCTGGCCA |
ACATGGTGAA |
ACCCTGTCTG |
CATTAAAAAT |
ACTAGAGATT |
AGGCCAGGCA |
CAGTGACTCA |
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2881 |
CACCTGTAAT |
TCCAGCACTT |
TGGGAGACCG |
AGGCGGGTGG |
CTCACCTGAG |
GTCGGGAGTT |
CGAGACCACC |
CTGACCAACA |
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2961 |
TAGAGAAACC |
CCGTCTCCAC |
TAAAAATACA |
AAATTAGCCG |
GGCATGGTGG |
CACATACCTG |
TAATCCCAGC |
TACTCGGGAG |
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3041 |
GCTGTAATCC |
TAGCTACTCG |
GGAGGCTGAG |
GCAGGAGAAC |
CGCTTGAACC |
CGGGAGGCGG |
AGATTGCAGT |
GAGCTGAGAT |
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3121 |
CGCACCATTG |
CACTTCAGCC |
TGGGCAACAA |
GAGCAAAACT |
CCATCTCAAA |
AAAAAAAAAA |
ACATAAAAGA |
TTAGGTGGAG |
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3201 |
GTTGCAGTGA |
GCTGAGATCG |
CGCCACTGCA |
TTCCAGCCTG |
GGCAACAGAG |
CAAGACTCCG |
TCTCAAAAAA |
AAAAAAAATT |
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3281 |
TAAAAAGCGT |
CTTGAAGGAG |
TTGGGGGGGG |
AGAGAAGACA |
GGGCCGCCAG |
GGCTCTGAGC |
GCAGCGCCAG |
CCTGTGTGGG |
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3361 |
GCATGCAGGC |
TGTGCCCCAC |
GCCTGTGTTG |
GGAGAGAGAG |
TAGATGGGGT |
GCCTGGCCCT |
GTGAGTGGTT |
GTGAGTATGT |
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3441 |
GTGTCCGAGG |
GCAAGGGGGA |
CTCTGTCCCG |
GCTGCATGGG |
TGTTAGGTCC |
ACGGCATGCC |
CCGGGTGTGT |
GTTGTGCGTG |
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3521 |
CGTGCACTTG |
CACGGCATGT |
GCGTGCATGT |
TGACATGGCA |
GCCGGTGCAC |
CTGTGGCTCC |
TGTCGGCAGA |
CACGTGCCCT |
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3601 |
CCAGCCTCTC |
GCTCTCTCTC |
ATCCGTTCTC |
TTTCTCATCC |
TCACCCTCTT |
GCTCTCACTC |
CACCCTCCTG |
AGCTGCCATG |
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3681 |
TGGCCATCAC |
CACCTCTGTG |
GCCTCTGTTC |
TCAGGGCCTT |
TGTGTACCTC |
CTTCCCCCAG |
TGCCTACCTG |
AACCCTCCCT |
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3761 |
TCCATCCCCC |
CATGCTCCAG |
TCTGTGGTCC |
GGCAGCCTCC |
TCCCCAGGCT |
CCGGGGCCAC |
CCTCGGAAGG |
CCTGGTGGGC |
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3841 |
TCTGTCAGGG |
AAGGGGCCCA |
CAGGACTCCT |
CGAGGGCTGT |
GGTCGTCAAC |
CGCTGAGTGC |
AGGGTGTGAG |
CGGGACTCGG |
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3921 |
ATACTCTCTG |
AGGGCGGGAA |
CTAGGCAGTG |
TCTCAAGAGA |
TGCCAGGTGC |
ACAGGGGTTG |
GGGGCTGGGT |
TGGGGGGAGC |
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4001 |
ACAGGCCCTC |
GGGAGCCAGA |
AGGGGACTGG |
GGCTGTGGCT |
CAGGCCATGG |
ACAGAGCAGA |
GGCGCAGGGA |
CCTGAAGAAG |
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4081 |
CAGAGGGAGA |
AGCCTGGCCA |
ACATAGCGAG |
ACCCCATCTC |
TACTCAAAAG |
ACAAAAATTA |
GCTGGGTGTG |
GTGGCGTGTA |
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4161 |
CCTATAATCC |
CAGCTACTCA |
GGAGGCTGAG |
GCAGGAGAAT |
CACTTGAACC |
TGGGAGGGGG |
ATGTTGCAGT |
GAGTTGAGAT |
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4241 |
CACGCCACTG |
CACTCCAGCC |
TGGGTGACAG |
AGCGAGAACC |
TATCTCAAAA |
AAAAAAAAAA |
ACAGTGGGAG |
GTGACGTGGT |
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4321 |
GCTGCAGAGG |
CGGCAGTGGC |
CAGGACAGCG |
GGAGGGGCAC |
GGGAGGTGAG |
GCCTCTAGGC |
CAGTCATGAA |
CGCTGGGCCT |
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4401 |
GGCTGTGTCC |
CAAGGTCCCC |
AGAGCCCTTC |
CCCTGCTCCT |
GCCTGGTCCT |
CCAGGAGGGG |
AGCTAGGGGG |
CACAGCTCCT |
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4481 |
GCAGGGGCTG |
GCAGGACCAG |
ATAGGGGCAA |
TGCTGGGCCT |
CCTGCATTGG |
GACTGAGGCG |
TCTTCCTGCC |
CCTCCTACTG |
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4561 |
GCTGAGATCA |
GGGTCCTGGG |
CACACGGGAG |
GGACGGGGTT |
TAGCTGCCAG |
CATGGAGCGG |
GTTTGTCTGT |
TCATATTAGT |
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4641 |
CCCTGGGCAC |
CAGTCACCAG |
GAGCCTGCAG |
AACTGTGGGG |
AGAAAAGGTG |
GACGAGGCAG |
GAGGAAAAGA |
GGGGAGAGGG |
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4721 |
GCTTGTTGGC |
TGAGGGCTTT |
GGAGAGCGGC |
AGGCCCCAGC |
TCCTGTGGGA |
GGGGCACCTT |
GGTAGGTGTG |
TGTAGCCGTT |
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4801 |
GTCAGGGCCT |
CTAGGATGTG |
ACGTGTCAGG |
ATTGGCTCCT |
CTGGAGGCCA |
CGTTAGCATC |
CCGGCCTCTG |
TTCCTGCACC |
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4881 |
CTGTTGCCAG |
CCCAGCCAGG |
GAGACCCTAG |
CTCCTCCGGG |
AAGCTGCCCT |
CCTGTCCCAG |
GCCCCTCTCT |
GGCCTGTCTC |
|
4961 |
TGCAGCGCCT |
CCTCTGGGCA |
CCTGGGCCCT |
AGTCTTGGTT |
CCTGTCTGTC |
TGTCTGTCTC |
CTGCCCTCCC |
ACCCCTAATG |
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5041 |
CCGCCTGCCC |
ACCCCAGGGT |
GCCTGCTGCC |
TGCCCGCCGC |
CTGCCCACCC |
GCTGTAGCAT |
GCCCGAGCTG |
CCCGCATGCA |
|
5121 |
GGCTGCTGGA |
TGAGCCAACC |
CCCGCCTGGC |
CCAGCATTGG |
CCCCACCTGG |
TCCCGCCAGC |
CCCTGCAGGA |
GCTGTGCCCC |
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5201 |
CGAGCTCTCC |
TCCCAGAGGA |
TGCAGGCCCC |
CTGAGGTCCT |
GTCCTGCCCC |
CATGGGCCCC |
AGCTCTGCAG |
GCCAGGCCAG |
|
5281 |
GAGGCCCTCA |
TGTCAGCCCA |
CTGGCCCGAG |
GGGGGCCCTC |
CCTGACCCCG |
GAACAGAAGA |
TAGGGCAAGG |
CAGCCTGAAG |
|
5361 |
CCTGGGTCTC |
GTGCCCGCTG |
CCTCCCCAGC |
GTGGCCCTGC |
TCGCTCTTGT |
CTGGGAGCCA |
ACTTCAGTGC |
TACCAGCAGA |
|
5441 |
GCCACAGCCT |
GGGCCAGCCC |
TGGCAGGCAC |
TCCGCCCTGG |
CCTATCCATC |
CTGTGGGTGC |
TGTGGCCCTG |
GGCCTGCTTC |
|
5521 |
CTGGGCAGAA |
GTGGGAGGAA |
GTGCACACAC |
CTGTCAGGGA |
GGCCCCCTGG |
CCGAGGGACA |
CCTCAGGTCC |
CCATCTCGTT |
|
5601 |
TCTCCGTCAG |
CGTAGACTTG |
GGGCTCCCTC |
TCCCCTGCTA |
GCCTCCTCCA |
TCTCTTTCCA |
GGTCAGGGGA |
TGAGACAAGG |
|
5681 |
GACCCTGAGA |
ACAGTCTGGG |
GTGGGAGGGA |
GACCCCAGCT |
CCTCCAGCCC |
AGCAGGGCAG |
GGGGCTGTGC |
CAGCCTAGCT |
|
5761 |
CGGGAAACCC |
AGGAGGGGAA |
GGTGAGGGTC |
CCGACCCCTC |
CCTGGAGTGC |
CAGATGTGGA |
GCTGACACCA |
GCTGGGCGCT |
|
5841 |
GACCCCCCTC |
CCTGCCACTG |
GTTCTCACCC |
CCCTAGCCCT |
GCAGCTCCCG |
CTGGCCAACG |
ATGGGGGCAG |
CCGCTCGCCA |
|
5921 |
TCCTCAGAGA |
GCTCCCCGCA |
GCACCCCACG |
CCCCCCGCCC |
GGCCCCGCCA |
CATGCTGGGG |
CTCCCGTCAA |
CCCTGTTCAC |
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6001 |
ACCCCGCAGC |
ATGGAGAGGT |
GAGCCAGGGG |
CCCAGCAGGG |
TTGGGTGGGA |
AGCAGCATTG |
AGGGGCCACC |
GTGCCAGCCC |
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6081 |
TGGGAGGAGG |
GTGGTTAAAC |
CGGTGGGAAC |
CCCGGTATGG |
GGGACTGGGG |
TGGCCAACCT |
AAGGTCAGGA |
CCCACCTCCA |
|
6161 |
CCGGCACCTG |
CTCCATGTCC |
CCAGCATTGA |
GATTGACCAG |
AAGCTGCAGG |
AGATCATGAA |
GCAGACGGGC |
TACCTGACCA |
|
6241 |
TCGGGGGCCA |
GGTACCACCT |
TCACTGTGGC |
GGGGAGAGGG |
AGGAGGCCCA |
GCCAGGCTGG |
ACCCATCCTG |
GGAGCGCCAG |
|
6321 |
TGGGGGGCAG |
GGGGCGGTGG |
CAGAGGCCCC |
AGGGACCCTC |
CAACCCTCCC |
TCTCCTCCCA |
GCGCTACCAG |
GCAGAAATCA |
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6401 |
ACGACCTGGA |
GAACTTGGGC |
GAGATGGGCA |
GCGGCACCTG |
CGGCCAGGTG |
TGGAAGATGC |
GCTTCCGGAA |
GACCGGCCAC |
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6481 |
GTCATTGCCG |
TTAAGGTGAG |
CCTTGGCGGC |
TACCCCGGCT |
GCGCCCCACA |
CCCCAGGCCG |
GTGCTGAGGC |
TCCCTCCTGT |
|
6561 |
CCCTGCCTGT |
GCAGCAAATG |
CGGCGCTCCG |
GGAACAAGGA |
GGAGAACAAG |
CGCATCCTCA |
TGGACCTGGA |
TGTGGTGCTG |
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6641 |
AAGAGCCACG |
ACTGCCCCTA |
CATCGTGCAG |
TGCTTTGGGA |
CGTTCATCAC |
CAACGTGAGT |
ACCTGGCCGC |
GCCCTGCAGC |
|
6721 |
GTCTCCTCCT |
CCCTCACCCC |
TGCCCCTTCC |
TAGGGAGCAG |
AGCCTCTGGG |
GGGTGGGCCG |
GAAGACACAG |
CTCCCCCGGG |
|
6801 |
TGCCCCTCTC |
CCTGCAGACG |
GACGTCTTCA |
TCGCCATGGA |
GCTCATGGGC |
ACCTGCGCTG |
AGAAGCTCAA |
GAAGCGGATG |
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6881 |
CAGGGCCCCA |
TCCCCGAGCG |
CATTCTGGGC |
AAGATGACAG |
TGGCGGTGAG |
TGACCAGGCG |
GGGCTTGCAC |
TGGGCAGGAT |
|
6961 |
GACAGAGGCG |
GTGAGTGACC |
AGGCGGGGCG |
TGCACTGGGC |
AAGATGACAG |
TGGCGGTGAG |
TGGCCAGGTG |
GGGCGTGCAC |
|
7041 |
CGGGCAGGTG |
GCCTTGGGTC |
TGTGCCCCCT |
GCCACATGCA |
CCCCCCTCTG |
CGTGCCTGCA |
GATTGTGAAG |
GCGCTGTACT |
|
7121 |
ACCTGAAGGA |
GAAGCACGGT |
GTCATCCACC |
GCGACGTCAA |
GCCCTCCAAC |
ATCCTGCTGG |
ACGAGCGGGG |
CCAGATCAAG |
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7201 |
CTCTGCGACT |
TCGGCATCAG |
CGGCCGCCTG |
GTGGACTCCA |
AAGCCAAGAC |
GCGGAGCGCC |
GGCTGTGCCG |
CCTACATGGC |
|
7281 |
AGTGAGTGGG |
GGCCCCCCAG |
CGGGGGAGGG |
GGTGGGGGCT |
GGGAGGCCGG |
CCCCAGCCTT |
GGAGATACGT |
CTTCTCCTCC |
|
7361 |
CCCCCCTGCA |
GCCCGAGCGC |
ATTGACCCCC |
CAGACCCCAC |
CAAGCCGGAC |
TATGACATCC |
GGGCCGACGT |
ATGGAGCCTG |
|
7441 |
GGCATCTCGT |
TGGTGAGTTG |
GGGCCCTCCC |
CTGTTCTCCA |
GCCAGGAGTG |
AGGGCTTCTG |
GGGGACTCGG |
AGGGAGGAGA |
|
7521 |
ACATAAACCT |
GTCCAGCCCT |
GCCCGTCTCC |
CTCCCAGGTG |
GAGCTGGCAA |
CAGGACAGTT |
TCCCTACAAG |
AACTGCAAGA |
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7601 |
CGGACTTTGA |
GGTCCTCACC |
AAAGTCCTAC |
AGGAAGAGCC |
CCCGCTTCTG |
CCCGGACACA |
TGGGCTTCTC |
GGGGGACTTC |
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7681 |
CAGTCCTTCG |
TCAAAGACTG |
GTGAGAACCT |
CCCTCCACTT |
GGGAGGTCAG |
GGACAGCCCG |
CTGCTCTGGG |
CAGCTGGGGA |
|
7761 |
GGCAATGGCA |
GGAGGGGAAT |
GGAGGCCGCA |
CCCTGGGATG |
GGCGGATGCG |
ACTGTGGGCG |
GGCTCCTGGC |
TGGCGGCTGC |
|
7841 |
CACAGGAGCT |
GGAGCTGGTG |
CCCAGGGAGC |
CATGAGCTGG |
GTTTGGACCT |
AGCCTGAGGG |
GACAGCCAGC |
CCTGTGGCAT |
|
7921 |
TTGGCGGGGT |
GGCTGTTGGA |
GATTGTGAGC |
ACGCTTCTGC |
AACAAGCACA |
GCTACAAGTT |
CAGGAGGGCC |
ATGTTCGATT |
|
8001 |
CTCTCAGGGG |
AGCCCCACCC |
ACCTTTCTGG |
GGGACCTCAG |
CCAGCTCTGG |
CCCCCCAAGC |
CAGGCCCTTG |
CCACCTGGCC |
|
8081 |
CTAGGCCAGG |
AGGCTCCGGG |
ACTCACAGTT |
GCTCCCCGCT |
GTCAGCCGGG |
GTCCTGAGGA |
CATCCACAGC |
TCCTTCCCCC |
|
8161 |
ACACACATCT |
TGGGGACCCC |
TGGCCCCTTG |
GGGAGGGCCT |
GAGCACAGGG |
GTGGGGCCGG |
CATCCCCTCC |
TCCCTCGTTC |
|
8241 |
TCACATCTGT |
CTTCCCTTCT |
CTTGCTCTAG |
CCTTACTAAA |
GATCACAGGA |
AGAGACCAAA |
GTATAATAAG |
CTACTTGTGA |
|
8321 |
GTACCTGAGC |
CCTCCCAGTC |
CCCGTCCTGT |
CCCTGCGGAG |
GCGCGAGGCC |
AGGAGGGAAG |
ACCGTCTCCT |
CCTAAGCCCC |
|
8401 |
ACCCCCTCGG |
GCCCACAGGA |
ACACAGCTTC |
ATCAAGCGCT |
ACGAGACGCT |
GGAGGTGGAC |
GTGGCGTCCT |
GGTTCAAGGA |
|
8481 |
TGTCATGGCG |
AAGACTGAGT |
CACCGCGGAC |
TAGCGGCGTC |
CTGAGCCAGC |
CCCACCTGCC |
CTTCTTCAGG |
TAGCTGCTTG |
|
8561 |
GCGGCGGCCA |
GCCCCACAGG |
GGGCCAGGGG |
CATGGCCACA |
GGCCCCCCTC |
CCCACTTGGC |
CACCCAGCTG |
CCTGCCAGGG |
|
8641 |
GAGACCTGGG |
ACCTGGACGG |
CCACCTAGGA |
CTGAGGACAG |
AGAGTGGGGG |
GTGCCCACCC |
ACCCCCCCCG |
CCCCGGGCCT |
|
8721 |
ACCAAGCCCC |
CGCCCTTCCC |
ACCCCGGGGT |
CAGCCGGCCG |
TGTGCGTCCC |
CCGACAGACA |
CTGTGAACGG |
AAGACAGCAG |
|
8801 |
GCCGCGATCA |
GAGTCGCTGT |
TCATTCAGCC |
GCAGCCTCTG |
GGCCGGGGCG |
GCCCCCAGGG |
GCCAGGAGAG |
AGCCCTGGAG |
|
8881 |
TCCCGCAGCC |
ACCATGCACG |
CTCCCAGCGT |
GCTGTGTCCT |
TCGCCACTCC |
CACGCGCCCG |
TTCCTCTTCC |
GTCGCCCTCT |
|
8961 |
GTCCCCTGCT |
CTACCTCTCT |
GTCCTTGTCT |
GGCTCTCCCG |
TCACCCTCCC |
TGCCTCTGTC |
TCTCTTCTGG |
CCTGAGCCTG |
|
9041 |
GGCCCAGCCA |
CCTCCTGACG |
GGTCCCCTGG |
GTCTGCATAG |
GTCTCCCATG |
GCGCAATGAG |
TCAGTGGCCC |
CCAGCCAGGC |
|
9121 |
AGTGTGGGCA |
TTGCCACTGC |
GGCTGGACGG |
GGCTGCGCGC |
TCGCGCTCTC |
TCTCTCTCTC |
TCTCTCTCTC |
TTTGATCTCA |
|
9201 |
GGGGGTCCTT |
TTTGGAGTTT |
ATTGTATTTT |
ATTGTACTTG |
GTGGGGTGTT |
TGGGGTGGGG |
GCGGAGGAGA |
GCTTGTTCTC |
|
9281 |
GTGGGGTTGT |
CGGTACCTTC |
AGAAACTTTT |
ACCAAAGTCA |
CGATTAGCTG |
CTTGTGGTGG |
GGCCCCAACC |
GCCCTCGGGC |
|
9361 |
ACTGGGGAGC |
TGGGCTGGGG |
CTGCTGCTCT |
GGGGTCTCCG |
GGGGCCACAG |
CTTGGGGTGA |
GTTGAAGACC |
TCAGGGGATG |
|
9441 |
TGGAGGGGTC |
TGCGGGGCCC |
TGGCCGCACA |
GGATGGCCTT |
CAGGGAAGGT |
GGTCTTGGGG |
CATGGTGCAG |
AGCAGGTGAC |
|
9521 |
CGGAGGGAAT |
CGGTGACGGA |
GCGGGGCCAA |
GGGAGGGGTC |
CGGAGGGAGT |
CAGGGATGGA |
GGGCAGAGGG |
AGTGGATGTG |
|
9601 |
GGGGTTTGAG |
GACGTGTGAC |
AAGCTCCAGC |
AGGGGTGGGG |
GCCGGGCTGA |
GGGTGGGGGT |
GCGAGGTGGT |
CACTCCCATC |
|
9681 |
GTGCCCCTGG |
CCGTCCCTCC |
ACTCACCCAC |
ACCTGGCCCA |
GTCCACGTTG |
AGGTCCAGGA |
CTGGGAAGGA |
CCGGGTGAGT |
|
9761 |
GCACCGGGGA |
CCCAGGCCAG |
GTGCCCCCCG |
GAGCCTGCTG |
GGGTGGCCAG |
AGCAGGAGGG |
GGTGTGTTTC |
CTTTTTGTGG |
|
9841 |
GTGTTGCATG |
CAAATCAAGT |
GGACAAGAAA |
AAATAACAAA |
ACAAAAAACA |
AGAAAAAAAA |
AACACAAAAC |
CCCGTAAAAT |
|
9921 |
CACAAAGAAA |
ATCCAACACC |
AAAGGCGCAG |
AAGCCGGCTG |
GCCGTGGTGG |
GGGCAGCGTA |
GGCGTAGCAT |
CCCTCTCCTC |
|
10001 |
TCACTTAGCC |
TGTTGACTCT |
TGTTATTATC |
ATGATATTCA |
CAAAACGCCG |
CATGTTTAAA |
AAGTCATAGA |
TGTCATCTTC |
|
10081 |
TCTCTGCCCC |
CAGGGAGGAA |
AGCCACCTTC |
TCTTGCCCCT |
TGGCCCCTTT |
GTCAGGGGCC |
AGGGGTCTGC |
CGGGTGGGGG |
|
10161 |
TGCCAACAGG |
CCTGGCCCTT |
TCCTCCCCTG |
CATCCAGCCA |
TGGGGGCCTC |
TGCGATTGCC |
GGAAGGTTGC |
ATGGCTGGTC |
|
10241 |
CCAGGGCCAG |
CACAGGCCCG |
AGGCCGGGCT |
GCCTGGTTTT |
ATTTTTATTT |
AACTTTATTT |
TCTGTTTTAT |
GAGTGTGTGT |
|
10321 |
CCGCCCACCC |
CCACCCCCTT |
CAGTGTTAAG |
TGGGGAGCCC |
TGGGGGAGTC |
TCTCCTGCCT |
CCCAGCCTCT |
CCCAAGACCT |
|
10401 |
CCCCCCTCGT |
CACCAGCCAT |
CCCTCTGGAC |
CAGGCAGAGG |
GCGGACCGGG |
TGGGCAGGGG |
CCTGAGGGTG |
GCTCGGGCCA |
|
10481 |
GCCCACCAGC |
CAATGGACCC |
CTCCTCAGGC |
CGCCAGTGTC |
GCCCTGCCCC |
TTTTTAAAAC |
AAAATGCCCT |
CGTTTGTAAA |
|
10561 |
CCCTTAGACG |
CTTGAGAATA |
AACCCCTTCC |
TTTTCTTCC |
|
|
|
|
|
|
|
|
|
|
|
|
>ref|Gene_ID:5609|MAP2K7|NC_000019.9:7968764...7979362 (+)
TGCGGTGTTTGTCTGCCGGACTGACGGGCGGCCGGGCGGTGCGCGGCGGCGGTGGCGGCGGGGAAGATGGCGGCGTCCTC
CCTGGAACAGAAGCTGTCCCGCCTGGAAGCAAAGCTGAAGCAGGAGAACCGGGAGGCCCGGCGGAGGATCGACCTCAACC
TGGATATCAGCCCCCAGCGGCCCAGGCCCAGTAAGCACGGCGGCGTGGGGGAGGGGGCGGGCGGGCGGGGCGGGGCGCGC
GCCGCGGGAGGCCCCGCCCCCACCACAAGGCCCCGCCCCCGCTTCCGGGGCGCTCGCTCTCCTCTCCGCCCCCCCCGCTG
CGGGCTCGCGGGGCGAGGGTCACGGTGACCCGGGGGGCGTGGAGCCGGCGAGCTCCGGGGGGTTCGCACCCTCAGGGCTT
GGGAGCCCAGTTCCCGGACCCAGGCGAGGCCCCCAGCTGATGACCCGCCCCCATCGCCGTGATCCTCTGGGTCGGGCTTC
CCCGACTCCACGCGACAGTGACCACATCCAGGTCGCCCCGAAAACACAGACACGTCCCTGTTGACCTGATGCTACCACTC
TCGTCATCTCAGGGACTGTCTGGCGCCCCCCTCCCCCGGCCTGGGGGCTTGTCAGCCCCGTGCAGCGACGATCTACGCAC
ACGCGCACGCCTGGCTCGGGGACACCTGAGGTTACTTGACCACATAGAGCCCCTCCCCATCTCTTCTGACCCGAGGATTC
TCCCTCTCGCTCTCCCTGTGACCGTGTCTGAGGTGGGGGGACGGGAGGGGGTCCCTTCTCCCCCTCTTGGCGACAGTGAC
CATGGCATTGGGCTCAGCAGACCCCCTCCCACATACACCAGGCCCCGCAAATCCCTGTGACCAGTTTCACTGCCACCATC
TTGGTGAGCGTGTGGTGTCTGACCTCCAGAAATGCACATCGACCCCCAGCCAGCCCGGTGACTTTGTCACCTGTGTTCAA
GTGATGGCTCCCCTTCCCTTCACACCCACACCCACCTGACCTGGGGACACCTGGGGCCAGTGTGACTCTAGGCCTGCTCC
CGCCGCGCCCCAGCATACATCCACCTGCTTTCTGATCAGTCCCACCACCTCGGTACCTACCTCCCTGACACCTTGTCATC
CTAGATCAGTACCTCTCGCTTCACACACACCTGGCCTGGGAACACTGACCATATCTAGTCTCCCGGCTTTTTCCCCAAGA
TCCTGGTCTCTAAATCCTCTGGGCTGGAGGAAATTAGATTTTCAAACCCTGTGAACACCACCCCTGACCCATGATCCTTT
TTGTGTCTTTCTTGACCCAGTAAAATTCTCTCTTGTCTCCTCTGATGTGACCTTCGTAGTTTATTTAGTTCTCTCTATGG
AGTCATTATGGCAGGCGAGAAAGGTACCCCCGTATCTGGGCACCCCACCCATTCCCTGGTCACCCAGCCTGACCTTCACA
GCCTGACACCCTCCTGTCCCTCCCTCTCCTGACCTGAGTCAGCGTGGGTTCCTCCTTGGGGAGTCTCTTGGGGGTCCAGA
GAAATCATGGAGGTGGGGATTCTGGTGCAGGACACTGCCTGAGACAAGAAGCCCAGCCAAGACACGGGTCCCTGCTAGCC
CCTGGGGGCCGCCCTCCCTGGCCCCTGAGTGGATGAGACAGGGTTGAGTCCAGGATCCCGGGTGCCTTCAGGGGTGGCCG
TTCCCATGCAGAGCTAGGAGGCCGGTGGCAGGCAGGCCCCCGAGGAGTCCCCTCCAGGCGTCTCTGTCTGTGTCAACTCC
ATCCCATCCTCCCCGCCCTCCCCATCTCTGTCGGTTCCTAGCCATCTCTGCAGTTCGGTGCCTCCCCCTCCTCCTCGTTT
ATGATTTGATTTCTTTTCTTTTGGACGAATCAGTCGTTTCTGTTGTGATTTATCGTGGTGTTGTTTTTTTCTTCCTTTTC
CCCATCCAGTTATTGTGATCACTCTAAGCCCTGCTCCTGCCCCGTCCCAACGAGCAGGTACCAGCCTTTTTATCATCGCT
GCTTGGACATCTGCACCATTGACCTAACCGCTGCCCCGGCCGCAGAATGGCGTCCCCCAGCCCCCATGCTCTGTGTGTGT
CCCCATGTCCCTTCCCCTCACTCTCACTTTCTCTCTCACTCCACTCAAGCAGCGGTCAGCCCAGCCCAGCCTCCTCTGCG
TCCTCCCTCCTCCTCCCCCTCCCTTACTCCCAGCTCCACTTTGGACTCCCTGGAGGAGGAGGTGGGCTCCCCCACTGAAT
GGGAGTCTGTGGCCTCCGGGGGTGGGGGGGGTGCACGCCTGTGTGTGTGTAACTGAGAGAACGAGAAAGTTGGGCCTGGT
GGGTGGGTGGCCTGTGCCTATGGATCTCTCTCAACAACTAGGTGAACACATAGCACCCCCCGGGTTCCATACCAGCCCTG
GGCGCCAGGGACACAGCAGTGAATAGAACAGATGGAGCCCCTCTCCTCTGTAGCGGGGGGCTGCAATAGGGGGGCCCACT
GGACAAGGAGCACATTCCCACCAGAGAGAACATTCTAGCTGGGTGAGCGGCCCTGCAGGGGGCCAGCCTGGGGGAACCTC
TGGAGACGGTGGGAATTGAACAAAGCCTCTGGGGAGGCCAGGCACGGTGGCTCACACCTGTGATCCCAACACTCGGGGAG
GTTGAGGCTACAGGGAGCCATGATCACACCACTGCACCCCAGCCTGGGTGACAGCGAGATCCTGTCTCAAAAATTTAAAA
ACTGGGCCAGGCGCAGTGGCTCATGCCTGTAATTTCAGTACTTTGGGAGGCCAAGGAGGGTGGATCACTTGAGGTCAGGA
GTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTGCATTAAAAATACTAGAGATTAGGCCAGGCACAGTGACTCA
CACCTGTAATTCCAGCACTTTGGGAGACCGAGGCGGGTGGCTCACCTGAGGTCGGGAGTTCGAGACCACCCTGACCAACA
TAGAGAAACCCCGTCTCCACTAAAAATACAAAATTAGCCGGGCATGGTGGCACATACCTGTAATCCCAGCTACTCGGGAG
GCTGTAATCCTAGCTACTCGGGAGGCTGAGGCAGGAGAACCGCTTGAACCCGGGAGGCGGAGATTGCAGTGAGCTGAGAT
CGCACCATTGCACTTCAGCCTGGGCAACAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAACATAAAAGATTAGGTGGAG
GTTGCAGTGAGCTGAGATCGCGCCACTGCATTCCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAATT
TAAAAAGCGTCTTGAAGGAGTTGGGGGGGGAGAGAAGACAGGGCCGCCAGGGCTCTGAGCGCAGCGCCAGCCTGTGTGGG
GCATGCAGGCTGTGCCCCACGCCTGTGTTGGGAGAGAGAGTAGATGGGGTGCCTGGCCCTGTGAGTGGTTGTGAGTATGT
GTGTCCGAGGGCAAGGGGGACTCTGTCCCGGCTGCATGGGTGTTAGGTCCACGGCATGCCCCGGGTGTGTGTTGTGCGTG
CGTGCACTTGCACGGCATGTGCGTGCATGTTGACATGGCAGCCGGTGCACCTGTGGCTCCTGTCGGCAGACACGTGCCCT
CCAGCCTCTCGCTCTCTCTCATCCGTTCTCTTTCTCATCCTCACCCTCTTGCTCTCACTCCACCCTCCTGAGCTGCCATG
TGGCCATCACCACCTCTGTGGCCTCTGTTCTCAGGGCCTTTGTGTACCTCCTTCCCCCAGTGCCTACCTGAACCCTCCCT
TCCATCCCCCCATGCTCCAGTCTGTGGTCCGGCAGCCTCCTCCCCAGGCTCCGGGGCCACCCTCGGAAGGCCTGGTGGGC
TCTGTCAGGGAAGGGGCCCACAGGACTCCTCGAGGGCTGTGGTCGTCAACCGCTGAGTGCAGGGTGTGAGCGGGACTCGG
ATACTCTCTGAGGGCGGGAACTAGGCAGTGTCTCAAGAGATGCCAGGTGCACAGGGGTTGGGGGCTGGGTTGGGGGGAGC
ACAGGCCCTCGGGAGCCAGAAGGGGACTGGGGCTGTGGCTCAGGCCATGGACAGAGCAGAGGCGCAGGGACCTGAAGAAG
CAGAGGGAGAAGCCTGGCCAACATAGCGAGACCCCATCTCTACTCAAAAGACAAAAATTAGCTGGGTGTGGTGGCGTGTA
CCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGGGGATGTTGCAGTGAGTTGAGAT
CACGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGAACCTATCTCAAAAAAAAAAAAAAACAGTGGGAGGTGACGTGGT
GCTGCAGAGGCGGCAGTGGCCAGGACAGCGGGAGGGGCACGGGAGGTGAGGCCTCTAGGCCAGTCATGAACGCTGGGCCT
GGCTGTGTCCCAAGGTCCCCAGAGCCCTTCCCCTGCTCCTGCCTGGTCCTCCAGGAGGGGAGCTAGGGGGCACAGCTCCT
GCAGGGGCTGGCAGGACCAGATAGGGGCAATGCTGGGCCTCCTGCATTGGGACTGAGGCGTCTTCCTGCCCCTCCTACTG
GCTGAGATCAGGGTCCTGGGCACACGGGAGGGACGGGGTTTAGCTGCCAGCATGGAGCGGGTTTGTCTGTTCATATTAGT
CCCTGGGCACCAGTCACCAGGAGCCTGCAGAACTGTGGGGAGAAAAGGTGGACGAGGCAGGAGGAAAAGAGGGGAGAGGG
GCTTGTTGGCTGAGGGCTTTGGAGAGCGGCAGGCCCCAGCTCCTGTGGGAGGGGCACCTTGGTAGGTGTGTGTAGCCGTT
GTCAGGGCCTCTAGGATGTGACGTGTCAGGATTGGCTCCTCTGGAGGCCACGTTAGCATCCCGGCCTCTGTTCCTGCACC
CTGTTGCCAGCCCAGCCAGGGAGACCCTAGCTCCTCCGGGAAGCTGCCCTCCTGTCCCAGGCCCCTCTCTGGCCTGTCTC
TGCAGCGCCTCCTCTGGGCACCTGGGCCCTAGTCTTGGTTCCTGTCTGTCTGTCTGTCTCCTGCCCTCCCACCCCTAATG
CCGCCTGCCCACCCCAGGGTGCCTGCTGCCTGCCCGCCGCCTGCCCACCCGCTGTAGCATGCCCGAGCTGCCCGCATGCA
GGCTGCTGGATGAGCCAACCCCCGCCTGGCCCAGCATTGGCCCCACCTGGTCCCGCCAGCCCCTGCAGGAGCTGTGCCCC
CGAGCTCTCCTCCCAGAGGATGCAGGCCCCCTGAGGTCCTGTCCTGCCCCCATGGGCCCCAGCTCTGCAGGCCAGGCCAG
GAGGCCCTCATGTCAGCCCACTGGCCCGAGGGGGGCCCTCCCTGACCCCGGAACAGAAGATAGGGCAAGGCAGCCTGAAG
CCTGGGTCTCGTGCCCGCTGCCTCCCCAGCGTGGCCCTGCTCGCTCTTGTCTGGGAGCCAACTTCAGTGCTACCAGCAGA
GCCACAGCCTGGGCCAGCCCTGGCAGGCACTCCGCCCTGGCCTATCCATCCTGTGGGTGCTGTGGCCCTGGGCCTGCTTC
CTGGGCAGAAGTGGGAGGAAGTGCACACACCTGTCAGGGAGGCCCCCTGGCCGAGGGACACCTCAGGTCCCCATCTCGTT
TCTCCGTCAGCGTAGACTTGGGGCTCCCTCTCCCCTGCTAGCCTCCTCCATCTCTTTCCAGGTCAGGGGATGAGACAAGG
GACCCTGAGAACAGTCTGGGGTGGGAGGGAGACCCCAGCTCCTCCAGCCCAGCAGGGCAGGGGGCTGTGCCAGCCTAGCT
CGGGAAACCCAGGAGGGGAAGGTGAGGGTCCCGACCCCTCCCTGGAGTGCCAGATGTGGAGCTGACACCAGCTGGGCGCT
GACCCCCCTCCCTGCCACTGGTTCTCACCCCCCTAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCCGCTCGCCA
TCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCAC
ACCCCGCAGCATGGAGAGGTGAGCCAGGGGCCCAGCAGGGTTGGGTGGGAAGCAGCATTGAGGGGCCACCGTGCCAGCCC
TGGGAGGAGGGTGGTTAAACCGGTGGGAACCCCGGTATGGGGGACTGGGGTGGCCAACCTAAGGTCAGGACCCACCTCCA
CCGGCACCTGCTCCATGTCCCCAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCA
TCGGGGGCCAGGTACCACCTTCACTGTGGCGGGGAGAGGGAGGAGGCCCAGCCAGGCTGGACCCATCCTGGGAGCGCCAG
TGGGGGGCAGGGGGCGGTGGCAGAGGCCCCAGGGACCCTCCAACCCTCCCTCTCCTCCCAGCGCTACCAGGCAGAAATCA
ACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCCAC
GTCATTGCCGTTAAGGTGAGCCTTGGCGGCTACCCCGGCTGCGCCCCACACCCCAGGCCGGTGCTGAGGCTCCCTCCTGT
CCCTGCCTGTGCAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTG
AAGAGCCACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACGTGAGTACCTGGCCGCGCCCTGCAGC
GTCTCCTCCTCCCTCACCCCTGCCCCTTCCTAGGGAGCAGAGCCTCTGGGGGGTGGGCCGGAAGACACAGCTCCCCCGGG
TGCCCCTCTCCCTGCAGACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTGAGAAGCTCAAGAAGCGGATG
CAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTGGCGGTGAGTGACCAGGCGGGGCTTGCACTGGGCAGGAT
GACAGAGGCGGTGAGTGACCAGGCGGGGCGTGCACTGGGCAAGATGACAGTGGCGGTGAGTGGCCAGGTGGGGCGTGCAC
CGGGCAGGTGGCCTTGGGTCTGTGCCCCCTGCCACATGCACCCCCCTCTGCGTGCCTGCAGATTGTGAAGGCGCTGTACT
ACCTGAAGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAG
CTCTGCGACTTCGGCATCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGC
AGTGAGTGGGGGCCCCCCAGCGGGGGAGGGGGTGGGGGCTGGGAGGCCGGCCCCAGCCTTGGAGATACGTCTTCTCCTCC
CCCCCCTGCAGCCCGAGCGCATTGACCCCCCAGACCCCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTG
GGCATCTCGTTGGTGAGTTGGGGCCCTCCCCTGTTCTCCAGCCAGGAGTGAGGGCTTCTGGGGGACTCGGAGGGAGGAGA
ACATAAACCTGTCCAGCCCTGCCCGTCTCCCTCCCAGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGAACTGCAAGA
CGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACATGGGCTTCTCGGGGGACTTC
CAGTCCTTCGTCAAAGACTGGTGAGAACCTCCCTCCACTTGGGAGGTCAGGGACAGCCCGCTGCTCTGGGCAGCTGGGGA
GGCAATGGCAGGAGGGGAATGGAGGCCGCACCCTGGGATGGGCGGATGCGACTGTGGGCGGGCTCCTGGCTGGCGGCTGC
CACAGGAGCTGGAGCTGGTGCCCAGGGAGCCATGAGCTGGGTTTGGACCTAGCCTGAGGGGACAGCCAGCCCTGTGGCAT
TTGGCGGGGTGGCTGTTGGAGATTGTGAGCACGCTTCTGCAACAAGCACAGCTACAAGTTCAGGAGGGCCATGTTCGATT
CTCTCAGGGGAGCCCCACCCACCTTTCTGGGGGACCTCAGCCAGCTCTGGCCCCCCAAGCCAGGCCCTTGCCACCTGGCC
CTAGGCCAGGAGGCTCCGGGACTCACAGTTGCTCCCCGCTGTCAGCCGGGGTCCTGAGGACATCCACAGCTCCTTCCCCC
ACACACATCTTGGGGACCCCTGGCCCCTTGGGGAGGGCCTGAGCACAGGGGTGGGGCCGGCATCCCCTCCTCCCTCGTTC
TCACATCTGTCTTCCCTTCTCTTGCTCTAGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGTGA
GTACCTGAGCCCTCCCAGTCCCCGTCCTGTCCCTGCGGAGGCGCGAGGCCAGGAGGGAAGACCGTCTCCTCCTAAGCCCC
ACCCCCTCGGGCCCACAGGAACACAGCTTCATCAAGCGCTACGAGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGA
TGTCATGGCGAAGACTGAGTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAGCTGCTTG
GCGGCGGCCAGCCCCACAGGGGGCCAGGGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCACCCAGCTGCCTGCCAGGG
GAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGACAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCCCGGGCCT
ACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACTGTGAACGGAAGACAGCAG
GCCGCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAGCCCTGGAG
TCCCGCAGCCACCATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCT
GTCCCCTGCTCTACCTCTCTGTCCTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTG
GGCCCAGCCACCTCCTGACGGGTCCCCTGGGTCTGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGC
AGTGTGGGCATTGCCACTGCGGCTGGACGGGGCTGCGCGCTCGCGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCA
GGGGGTCCTTTTTGGAGTTTATTGTATTTTATTGTACTTGGTGGGGTGTTTGGGGTGGGGGCGGAGGAGAGCTTGTTCTC
GTGGGGTTGTCGGTACCTTCAGAAACTTTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGCCCCAACCGCCCTCGGGC
ACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCAGGGGATG
TGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCATGGTGCAGAGCAGGTGAC
CGGAGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAGTGGATGTG
GGGGTTTGAGGACGTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATC
GTGCCCCTGGCCGTCCCTCCACTCACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGT
GCACCGGGGACCCAGGCCAGGTGCCCCCCGGAGCCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGG
GTGTTGCATGCAAATCAAGTGGACAAGAAAAAATAACAAAACAAAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAAT
CACAAAGAAAATCCAACACCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGGCAGCGTAGGCGTAGCATCCCTCTCCTC
TCACTTAGCCTGTTGACTCTTGTTATTATCATGATATTCACAAAACGCCGCATGTTTAAAAAGTCATAGATGTCATCTTC
TCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGGGTGGGGG
TGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGGAAGGTTGCATGGCTGGTC
CCAGGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGAGTGTGTGT
CCGCCCACCCCCACCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCT
CCCCCCTCGTCACCAGCCATCCCTCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCA
GCCCACCAGCCAATGGACCCCTCCTCAGGCCGCCAGTGTCGCCCTGCCCCTTTTTAAAACAAAATGCCCTCGTTTGTAAA
CCCTTAGACGCTTGAGAATAAACCCCTTCCTTTTCTTCC
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Primary source |
RefSeq : NM_145185.2 (GI:40806198)
|
Name |
Mitogen-activated protein kinase kinase 7 (MAP2K7)
|
Type of transcript |
mRNA
|
Organism |
Homo sapiens
|
Length |
3386 nt
|
Map |
19p13.3-p13.2
|
Location |
Chromosome 19 (NC_000019.9) strand : +
7968764...7968952 | 7974639...7974780 | 7974947...7975013 | 7975144...7975257 |
7975337...7975456 | 7975580...7975687 | 7975864...7976043 | 7976134...7976214 |
7976320...7976462 | 7977033...7977078 | 7977181...7979362 |
|
|
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|
Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
|
1
|
189
|
189
|
1
|
Exon 2
|
190
|
331
|
142
|
1
|
Exon 3
|
332
|
398
|
67
|
1
|
Exon 4
|
399
|
512
|
114
|
1
|
Exon 5
|
513
|
632
|
120
|
1
|
Exon 6
|
633
|
740
|
108
|
1
|
Exon 7
|
741
|
920
|
180
|
1
|
Exon 8
|
921
|
1001
|
81
|
1
|
Exon 9
|
1002
|
1144
|
143
|
1
|
Exon 10
|
1145
|
1190
|
46
|
1
|
Exon 11
|
1191
|
3372
|
2182
|
1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Primary source |
NCBI : CCDS42491
|
Nucleotide |
MAP2K7, mRNA isoform 1[NM_145185.2] : 66...1325
|
Length |
1260
|
Location |
Chromosome 19 (NC_000019.9) strand : +
7968829...7968952 | 7974639...7974780 | 7974947...7975013 | 7975144...7975257 |
7975337...7975456 | 7975580...7975687 | 7975864...7976043 | 7976134...7976214 |
7976320...7976462 | 7977033...7977078 | 7977181...7977315 |
|
Start codon |
1
|
Translation |
NP_660186.1 |
|
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|
1 |
GCGGTGTTTG |
TCTGCCGGAC |
TGACGGGCGG |
CCGGGCGGTG |
CGCGGCGGCG |
GTGGCGGCGG |
GGAAGATGGC |
GGCGTCCTCC |
|
81 |
CTGGAACAGA |
AGCTGTCCCG |
CCTGGAAGCA |
AAGCTGAAGC |
AGGAGAACCG |
GGAGGCCCGG |
CGGAGGATCG |
ACCTCAACCT |
|
161 |
GGATATCAGC |
CCCCAGCGGC |
CCAGGCCCAC |
CCTGCAGCTC |
CCGCTGGCCA |
ACGATGGGGG |
CAGCCGCTCG |
CCATCCTCAG |
|
241 |
AGAGCTCCCC |
GCAGCACCCC |
ACGCCCCCCG |
CCCGGCCCCG |
CCACATGCTG |
GGGCTCCCGT |
CAACCCTGTT |
CACACCCCGC |
|
321 |
AGCATGGAGA |
GCATTGAGAT |
TGACCAGAAG |
CTGCAGGAGA |
TCATGAAGCA |
GACGGGCTAC |
CTGACCATCG |
GGGGCCAGCG |
|
401 |
CTACCAGGCA |
GAAATCAACG |
ACCTGGAGAA |
CTTGGGCGAG |
ATGGGCAGCG |
GCACCTGCGG |
CCAGGTGTGG |
AAGATGCGCT |
|
481 |
TCCGGAAGAC |
CGGCCACGTC |
ATTGCCGTTA |
AGCAAATGCG |
GCGCTCCGGG |
AACAAGGAGG |
AGAACAAGCG |
CATCCTCATG |
|
561 |
GACCTGGATG |
TGGTGCTGAA |
GAGCCACGAC |
TGCCCCTACA |
TCGTGCAGTG |
CTTTGGGACG |
TTCATCACCA |
ACACGGACGT |
|
641 |
CTTCATCGCC |
ATGGAGCTCA |
TGGGCACCTG |
CGCTGAGAAG |
CTCAAGAAGC |
GGATGCAGGG |
CCCCATCCCC |
GAGCGCATTC |
|
721 |
TGGGCAAGAT |
GACAGTGGCG |
ATTGTGAAGG |
CGCTGTACTA |
CCTGAAGGAG |
AAGCACGGTG |
TCATCCACCG |
CGACGTCAAG |
|
801 |
CCCTCCAACA |
TCCTGCTGGA |
CGAGCGGGGC |
CAGATCAAGC |
TCTGCGACTT |
CGGCATCAGC |
GGCCGCCTGG |
TGGACTCCAA |
|
881 |
AGCCAAGACG |
CGGAGCGCCG |
GCTGTGCCGC |
CTACATGGCA |
CCCGAGCGCA |
TTGACCCCCC |
AGACCCCACC |
AAGCCGGACT |
|
961 |
ATGACATCCG |
GGCCGACGTA |
TGGAGCCTGG |
GCATCTCGTT |
GGTGGAGCTG |
GCAACAGGAC |
AGTTTCCCTA |
CAAGAACTGC |
|
1041 |
AAGACGGACT |
TTGAGGTCCT |
CACCAAAGTC |
CTACAGGAAG |
AGCCCCCGCT |
TCTGCCCGGA |
CACATGGGCT |
TCTCGGGGGA |
|
1121 |
CTTCCAGTCC |
TTCGTCAAAG |
ACTGCCTTAC |
TAAAGATCAC |
AGGAAGAGAC |
CAAAGTATAA |
TAAGCTACTT |
GAACACAGCT |
|
1201 |
TCATCAAGCG |
CTACGAGACG |
CTGGAGGTGG |
ACGTGGCGTC |
CTGGTTCAAG |
GATGTCATGG |
CGAAGACTGA |
GTCACCGCGG |
|
1281 |
ACTAGCGGCG |
TCCTGAGCCA |
GCCCCACCTG |
CCCTTCTTCA |
GGTAGCTGCT |
TGGCGGCGGC |
CAGCCCCACA |
GGGGGCCAGG |
|
1361 |
GGCATGGCCA |
CAGGCCCCCC |
TCCCCACTTG |
GCCACCCAGC |
TGCCTGCCAG |
GGGAGACCTG |
GGACCTGGAC |
GGCCACCTAG |
|
1441 |
GACTGAGGAC |
AGAGAGTGGG |
GGGTGCCCAC |
CCACCCCCCC |
CGCCCCGGGC |
CTACCAAGCC |
CCCGCCCTTC |
CCACCCCGGG |
|
1521 |
GTCAGCCGGC |
CGTGTGCGTC |
CCCCGACAGA |
CACTGTGAAC |
GGAAGACAGC |
AGGCCGCGAT |
CAGAGTCGCT |
GTTCATTCAG |
|
1601 |
CCGCAGCCTC |
TGGGCCGGGG |
CGGCCCCCAG |
GGGCCAGGAG |
AGAGCCCTGG |
AGTCCCGCAG |
CCACCATGCA |
CGCTCCCAGC |
|
1681 |
GTGCTGTGTC |
CTTCGCCACT |
CCCACGCGCC |
CGTTCCTCTT |
CCGTCGCCCT |
CTGTCCCCTG |
CTCTACCTCT |
CTGTCCTTGT |
|
1761 |
CTGGCTCTCC |
CGTCACCCTC |
CCTGCCTCTG |
TCTCTCTTCT |
GGCCTGAGCC |
TGGGCCCAGC |
CACCTCCTGA |
CGGGTCCCCT |
|
1841 |
GGGTCTGCAT |
AGGTCTCCCA |
TGGCGCAATG |
AGTCAGTGGC |
CCCCAGCCAG |
GCAGTGTGGG |
CATTGCCACT |
GCGGCTGGAC |
|
1921 |
GGGGCTGCGC |
GCTCGCGCTC |
TCTCTCTCTC |
TCTCTCTCTC |
TCTTTGATCT |
CAGGGGGTCC |
TTTTTGGAGT |
TTATTGTATT |
|
2001 |
TTATTGTACT |
TGGTGGGGTG |
TTTGGGGTGG |
GGGCGGAGGA |
GAGCTTGTTC |
TCGTGGGGTT |
GTCGGTACCT |
TCAGAAACTT |
|
2081 |
TTACCAAAGT |
CACGATTAGC |
TGCTTGTGGT |
GGGGCCCCAA |
CCGCCCTCGG |
GCACTGGGGA |
GCTGGGCTGG |
GGCTGCTGCT |
|
2161 |
CTGGGGTCTC |
CGGGGGCCAC |
AGCTTGGGGT |
GAGTTGAAGA |
CCTCAGGGGA |
TGTGGAGGGG |
TCTGCGGGGC |
CCTGGCCGCA |
|
2241 |
CAGGATGGCC |
TTCAGGGAAG |
GTGGTCTTGG |
GGCATGGTGC |
AGAGCAGGTG |
ACCGGAGGGA |
ATCGGTGACG |
GAGCGGGGCC |
|
2321 |
AAGGGAGGGG |
TCCGGAGGGA |
GTCAGGGATG |
GAGGGCAGAG |
GGAGTGGATG |
TGGGGGTTTG |
AGGACGTGTG |
ACAAGCTCCA |
|
2401 |
GCAGGGGTGG |
GGGCCGGGCT |
GAGGGTGGGG |
GTGCGAGGTG |
GTCACTCCCA |
TCGTGCCCCT |
GGCCGTCCCT |
CCACTCACCC |
|
2481 |
ACACCTGGCC |
CAGTCCACGT |
TGAGGTCCAG |
GACTGGGAAG |
GACCGGGTGA |
GTGCACCGGG |
GACCCAGGCC |
AGGTGCCCCC |
|
2561 |
CGGAGCCTGC |
TGGGGTGGCC |
AGAGCAGGAG |
GGGGTGTGTT |
TCCTTTTTGT |
GGGTGTTGCA |
TGCAAATCAA |
GTGGACAAGA |
|
2641 |
AAAAATAACA |
AAACAAAAAA |
CAAGAAAAAA |
AAAACACAAA |
ACCCCGTAAA |
ATCACAAAGA |
AAATCCAACA |
CCAAAGGCGC |
|
2721 |
AGAAGCCGGC |
TGGCCGTGGT |
GGGGGCAGCG |
TAGGCGTAGC |
ATCCCTCTCC |
TCTCACTTAG |
CCTGTTGACT |
CTTGTTATTA |
|
2801 |
TCATGATATT |
CACAAAACGC |
CGCATGTTTA |
AAAAGTCATA |
GATGTCATCT |
TCTCTCTGCC |
CCCAGGGAGG |
AAAGCCACCT |
|
2881 |
TCTCTTGCCC |
CTTGGCCCCT |
TTGTCAGGGG |
CCAGGGGTCT |
GCCGGGTGGG |
GGTGCCAACA |
GGCCTGGCCC |
TTTCCTCCCC |
|
2961 |
TGCATCCAGC |
CATGGGGGCC |
TCTGCGATTG |
CCGGAAGGTT |
GCATGGCTGG |
TCCCAGGGCC |
AGCACAGGCC |
CGAGGCCGGG |
|
3041 |
CTGCCTGGTT |
TTATTTTTAT |
TTAACTTTAT |
TTTCTGTTTT |
ATGAGTGTGT |
GTCCGCCCAC |
CCCCACCCCC |
TTCAGTGTTA |
|
3121 |
AGTGGGGAGC |
CCTGGGGGAG |
TCTCTCCTGC |
CTCCCAGCCT |
CTCCCAAGAC |
CTCCCCCCTC |
GTCACCAGCC |
ATCCCTCTGG |
|
3201 |
ACCAGGCAGA |
GGGCGGACCG |
GGTGGGCAGG |
GGCCTGAGGG |
TGGCTCGGGC |
CAGCCCACCA |
GCCAATGGAC |
CCCTCCTCAG |
|
3281 |
GCCGCCAGTG |
TCGCCCTGCC |
CCTTTTTAAA |
ACAAAATGCC |
CTCGTTTGTA |
AACCCTTAGA |
CGCTTGAGAA |
TAAACCCCTT |
|
3361 |
CCTTTTCTTC |
CAAAAAAAAA |
AAAAAA |
|
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|
>gi|40806198|ref|NM_145185.2|Mitogen-activated protein kinase kinase 7 (MAP2K7)
GCGGTGTTTGTCTGCCGGACTGACGGGCGGCCGGGCGGTGCGCGGCGGCGGTGGCGGCGGGGAAGATGGCGGCGTCCTCC
CTGGAACAGAAGCTGTCCCGCCTGGAAGCAAAGCTGAAGCAGGAGAACCGGGAGGCCCGGCGGAGGATCGACCTCAACCT
GGATATCAGCCCCCAGCGGCCCAGGCCCACCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCCGCTCGCCATCCTCAG
AGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACACCCCGC
AGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGCG
CTACCAGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCT
TCCGGAAGACCGGCCACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATG
GACCTGGATGTGGTGCTGAAGAGCCACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACGT
CTTCATCGCCATGGAGCTCATGGGCACCTGCGCTGAGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTC
TGGGCAAGATGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGAAGGAGAAGCACGGTGTCATCCACCGCGACGTCAAG
CCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCATCAGCGGCCGCCTGGTGGACTCCAA
AGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGCACCCGAGCGCATTGACCCCCCAGACCCCACCAAGCCGGACT
ATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGTTGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGAACTGC
AAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACATGGGCTTCTCGGGGGA
CTTCCAGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGAACACAGCT
TCATCAAGCGCTACGAGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCGCGG
ACTAGCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAGG
GGCATGGCCACAGGCCCCCCTCCCCACTTGGCCACCCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAG
GACTGAGGACAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCCCGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGG
GTCAGCCGGCCGTGTGCGTCCCCCGACAGACACTGTGAACGGAAGACAGCAGGCCGCGATCAGAGTCGCTGTTCATTCAG
CCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACCATGCACGCTCCCAGC
GTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGTCCCCTGCTCTACCTCTCTGTCCTTGT
CTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACCTCCTGACGGGTCCCCT
GGGTCTGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACTGCGGCTGGAC
GGGGCTGCGCGCTCGCGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGTTTATTGTATT
TTATTGTACTTGGTGGGGTGTTTGGGGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACTT
TTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGCCCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCT
CTGGGGTCTCCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCAGGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCA
CAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGGAGGGAATCGGTGACGGAGCGGGGCC
AAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGACGTGTGACAAGCTCCA
GCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGTGCCCCTGGCCGTCCCTCCACTCACCC
ACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACCCAGGCCAGGTGCCCCC
CGGAGCCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAAGTGGACAAGA
AAAAATAACAAAACAAAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACACCAAAGGCGC
AGAAGCCGGCTGGCCGTGGTGGGGGCAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATTA
TCATGATATTCACAAAACGCCGCATGTTTAAAAAGTCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCT
TCTCTTGCCCCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGGGTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCC
TGCATCCAGCCATGGGGGCCTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCAGGGCCAGCACAGGCCCGAGGCCGGG
CTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCACCCCCTTCAGTGTTA
AGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCCCCCCTCGTCACCAGCCATCCCTCTGG
ACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCAATGGACCCCTCCTCAG
GCCGCCAGTGTCGCCCTGCCCCTTTTTAAAACAAAATGCCCTCGTTTGTAAACCCTTAGACGCTTGAGAATAAACCCCTT
CCTTTTCTTCCAAAAAAAAAAAAAAA
|
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| |
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|
Exon number |
1
|
Length |
189 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7968764...7968952 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
GCGGTGTTTGTCTGCCGGACTGACGGGCGGCCGGGCGGTGCGCGGCGGCGGTGGCGGCGGGGAAGATGGCGGCGTCCTCC
CTGGAACAGAAGCTGTCCCGCCTGGAAGCAAAGCTGAAGCAGGAGAACCGGGAGGCCCGGCGGAGGATCGACCTCAACCT
GGATATCAGCCCCCAGCGGCCCAGGCCCA
|
|
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|
|
Exon number |
2
|
Length |
142 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7974639...7974780 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
CCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCCGCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCC
GCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACACCCCGCAGCATGGAGAG
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Exon number |
4
|
Length |
114 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7975144...7975257 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
CGCTACCAGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCG
CTTCCGGAAGACCGGCCACGTCATTGCCGTTAAG
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Exon number |
5
|
Length |
120 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7975337...7975456 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
CAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCCACGACTG
CCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAAC
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Exon number |
6
|
Length |
108 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7975580...7975687 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
ACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTGAGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGA
GCGCATTCTGGGCAAGATGACAGTGGCG
|
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|
Exon number |
7
|
Length |
180 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7975864...7976043 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
ATTGTGAAGGCGCTGTACTACCTGAAGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGA
CGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCATCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCG
GCTGTGCCGCCTACATGGCA
|
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Exon number |
9
|
Length |
143 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7976320...7976462 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
GTGGAGCTGGCAACAGGACAGTTTCCCTACAAGAACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGA
GCCCCCGCTTCTGCCCGGACACATGGGCTTCTCGGGGGACTTCCAGTCCTTCGTCAAAGACTG
|
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Exon number |
11
|
Length |
2182 nt
|
Location |
Chromosome 19 (NC_000019.9) : 7977181...7979362 (+)
|
Is part of |
MAP2K7, mRNA isoform 1
(NM_145185.2)
|
Sequence |
Show
|
|
GAACACAGCTTCATCAAGCGCTACGAGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGA
GTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACA
GGGGGCCAGGGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCACCCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGAC
GGCCACCTAGGACTGAGGACAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCCCGGGCCTACCAAGCCCCCGCCCTTC
CCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACTGTGAACGGAAGACAGCAGGCCGCGATCAGAGTCGCT
GTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACCATGCA
CGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGTCCCCTGCTCTACCTCT
CTGTCCTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACCTCCTGA
CGGGTCCCCTGGGTCTGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACT
GCGGCTGGACGGGGCTGCGCGCTCGCGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGT
TTATTGTATTTTATTGTACTTGGTGGGGTGTTTGGGGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCT
TCAGAAACTTTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGCCCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGG
GGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCAGGGGATGTGGAGGGGTCTGCGGGGC
CCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGGAGGGAATCGGTGACG
GAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGACGTGTG
ACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGTGCCCCTGGCCGTCCCT
CCACTCACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACCCAGGCC
AGGTGCCCCCCGGAGCCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAA
GTGGACAAGAAAAAATAACAAAACAAAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACA
CCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGGCAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACT
CTTGTTATTATCATGATATTCACAAAACGCCGCATGTTTAAAAAGTCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGG
AAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGGGTGGGGGTGCCAACAGGCCTGGCCC
TTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCAGGGCCAGCACAGGCC
CGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCACCCCC
TTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCCCCCCTCGTCACCAGCC
ATCCCTCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCAATGGAC
CCCTCCTCAGGCCGCCAGTGTCGCCCTGCCCCTTTTTAAAACAAAATGCCCTCGTTTGTAAACCCTTAGACGCTTGAGAA
TAAACCCCTTCCTTTTCTTCCA
|
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Primary source |
Uniprot : O14733
|
Name |
Dual specificity mitogen-activated protein kinase kinase 7
|
Alternative name(s) |
JNK-activating kinase 2 MAPK/ERK kinase 7 c-Jun N-terminal kinase kinase 2
|
Synonym(s) |
JNK kinase 2 JNKK 2 MAP kinase kinase 7 MAPKK 7 MEK 7
|
Organism |
Homo sapiens
|
Length |
419 aa
|
Protein existence |
---
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General annotation (Comments)
|
top
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Catalytic activity
|
ATP + a protein = ADP + a phosphoprotein.
|
Cofactor
|
Magnesium.
|
Enzyme regulation
|
Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.
|
Function
|
Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
|
Ptm
|
Activated by phosphorylation on Ser/Thr.
|
Similarity
|
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.
|
Subcellular location
|
Nucleus. Cytoplasm (By similarity).
|
Tissue specificity
|
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
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Biological process
|
protein amino acid phosphorylation [GO:0006468]
stress-activated MAPK cascade [GO:0051403]
|
Cellular component
|
nucleus [GO:0005634]
cytoplasm [GO:0005737]
|
Molecular function
|
magnesium ion binding [GO:0000287]
protein serine/threonine kinase activity [GO:0004674]
MAP kinase kinase activity [GO:0004708]
protein tyrosine kinase activity [GO:0004713]
ATP binding [GO:0005524]
protein kinase binding [GO:0019901]
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Alternative product(s)
|
top
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  |
Uniprot Identifier
|
Difference(s) with the 'canonical' sequence
|
Notes
|
Sequences
|
Isoform 1
|
O14733-1
|
---
|
'Canonical' sequence
|
Get Fasta
|
Isoform 2
|
O14733-2
|
111-111 : Q -> QVPPSLWRGEGGGPARLDPSWERQWGAGGGGRAPGT LQPSLSSQ
|
---
|
Get Fasta
|
Isoform 3
|
O14733-3
|
42-42 : T -> IIVITLSPAPAPSQRAA
|
---
|
Get Fasta
|
Isoform 4
|
O14733-4
|
312-312 : L -> LPCPSPSQ
|
---
|
Get Fasta
|
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Feature key |
Position
|
Length
|
Description
|
Feature identifier
|
Molecule processing |
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|
|
|
Initiator methionine
|
1 - 1
|
1
|
Removed
|
O14733-INIT_MET-1
|
Region |
|
|
|
|
Coiled coil
|
2 - 30
|
29
|
Potential
|
O14733-COILED-2
|
Domain
|
120 - 380
|
261
|
Protein kinase
|
O14733-DOMAIN-120
|
Nucleotide binding
|
126 - 134
|
9
|
ATP (By similarity)
|
O14733-NP_BIND-126
|
Sites |
|
|
|
|
Active site
|
243 - 243
|
1
|
Proton acceptor (By similarity)
|
O14733-ACT_SITE-243
|
Binding site
|
149 - 149
|
1
|
ATP (By similarity)
|
O14733-BINDING-149
|
Site
|
44 - 45
|
2
|
Cleavage; by anthrax lethal factor
|
O14733-SITE-44
|
Site
|
76 - 77
|
2
|
Cleavage; by anthrax lethal factor
|
O14733-SITE-76
|
Natural variations |
|
|
|
|
Natural variant site
|
118 - 118
|
1
|
N -> S (in dbSNP:rs56316660)
|
VAR_040825
|
Natural variant site
|
138 - 138
|
1
|
R -> C (in dbSNP:rs56106612)
|
VAR_040826
|
Natural variant site
|
162 - 162
|
1
|
R -> H (in a colorectal adenocarcinoma sample; somatic mutation)
|
VAR_040828
|
Natural variant site
|
162 - 162
|
1
|
R -> C (in a colorectal adenocarcinoma sample; somatic mutation)
|
VAR_040827
|
Natural variant site
|
195 - 195
|
1
|
A -> T (in dbSNP:rs55800262)
|
VAR_040829
|
Natural variant site
|
259 - 259
|
1
|
L -> F (in dbSNP:rs1053566)
|
VAR_029890
|
Alternative sequence
|
42 - 42
|
1
|
T -> IIVITLSPAPAPSQRAA
|
VSP_022309
|
Alternative sequence
|
111 - 111
|
1
|
Q -> QVPPSLWRGEGGGPARLDPSWERQWGAGGGGRAPGT LQPSLSSQ
|
VSP_004883
|
Alternative sequence
|
312 - 312
|
1
|
L -> LPCPSPSQ
|
VSP_022310
|
Amino acid modifications |
|
|
|
|
Modified residue
|
2 - 2
|
1
|
N-acetylalanine
|
O14733-MOD_RES-2
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
MAASSLEQKL |
SRLEAKLKQE |
NREARRRIDL |
NLDISPQRPR |
PTLQLPLAND |
GGSRSPSSES |
SPQHPTPPAR |
PRHMLGLPST |
|
81 |
LFTPRSMESI |
EIDQKLQEIM |
KQTGYLTIGG |
QRYQAEINDL |
ENLGEMGSGT |
CGQVWKMRFR |
KTGHVIAVKQ |
MRRSGNKEEN |
|
161 |
KRILMDLDVV |
LKSHDCPYIV |
QCFGTFITNT |
DVFIAMELMG |
TCAEKLKKRM |
QGPIPERILG |
KMTVAIVKAL |
YYLKEKHGVI |
|
241 |
HRDVKPSNIL |
LDERGQIKLC |
DFGISGRLVD |
SKAKTRSAGC |
AAYMAPERID |
PPDPTKPDYD |
IRADVWSLGI |
SLVELATGQF |
|
321 |
PYKNCKTDFE |
VLTKVLQEEP |
PLLPGHMGFS |
GDFQSFVKDC |
LTKDHRKRPK |
YNKLLEHSFI |
KRYETLEVDV |
ASWFKDVMAK |
|
401 |
TESPRTSGVL |
SQPHLPFFR |
|
|
|
|
|
|
|
|
|
|
|
|
>sp|O14733|MP2K7_human Dual specificity mitogen-activated protein kinase kinase 7
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPST
LFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEEN
KRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQF
PYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK
TESPRTSGVLSQPHLPFFR
|
|
|
| |
|
|
|
|
|
|