(PTK6) PTK6 protein tyrosine kinase 6 [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  10380
 Official symbol  PTK6
 Official name  PTK6 protein tyrosine kinase 6
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 20 (NC_000020.10) :  62159765...62168706  (-)
 Map  20q13.3
 Length  8942  nt
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Alternative name(s) and Synynom(s) top
Synonyms FLJ42088; BRK
Alternative name(s) pTK6 protein tyrosine kinase 6; protein-tyrosine kinase BRK; breast tumor kinase
External Links top
EC_number 2.7.10.1
Ensembl ENSG00000101213
Entrez 5753
HGNC 9617
HPRD 03594
Comment top
Summary The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. [provided by RefSeq].
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Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
1  CTGGGCCACA GCCTGGTCCT GCCGCTGCGC CCGCCCGCCA TGGTGTCCCG GGACCAGGCT CACCTGGGCC CCAAGTATGT
81  GGGCCTCTGG GACTTCAAGT CCCGGACGGA CGAGGAGCTG AGCTTCCGCG CGGGGGACGT CTTCCACGTG GCCAGGAAGG
161  AGGAGCAGTG GTGGTGGGCC ACGCTGCTGG ACGAGGCGGG TGGGGCCGTG GCCCAGGGCT ATGTGCCCCA CAACTACCTG
241  GCCGAGAGGG AGACGGTGGA GTCGGAACCG TGCGTGTCCT AGGCTGCTGG GAGCTTTGGC ACAGGCCACC CTCTAGGCAC
321  AGGGGAGGGA CAGGGCTCTG GGCTGCTCAG GGAGGCCCAA GAAGGTGGGG ACCCCGGTTC CATCTTCCTG CACCCCAAAG
401  TCCAGGCTGG GCATCCCGCT TGATCCTCCC TGCAGGCCCC ATGCGCTGGC GCCCAGGAGT GCCCAGGACT GTCCCTGCGG
481  GAGTTGGAGC ACGGGGGTCA GAGGGCACGG CCCCTGCCTT GGGCTCATCC TTGTCACAGC TCGGGGGTGG ACGCTGCATT
561  GCCGGGACCC AGGGAGGACA GAGGGTCCAG GGTGGACTTC TGGGGCCCGG TGGCCAGTGA CAAGGTCTGT CGGAGCGTTC
641  CAGGGCCTTT GGGGGAAACG AAGCTTGAAG CTTGCCCAGT TTCCAAAGTG CCGGAACCAG ACACACGACC TAGTTAGGGG
721  AGCGGGCCGG CTGCCGGGCA AACTTCCTGC CTGCTGTGCC CTGCGGGGAA CCAGACAGCA GCTGGTGTGG CCTGGCCCTG
801  GCTTCCACAG CTGCCCGGAG CTCAGGCTGA GGAGGGTCAC GCTCCTGAGA TCCCGCGTTT CTCATCAGTG ATTGGGCACC
881  CACTGTGTGT GTGCGTGAGT CACAGGCTGT GTAGGGTTAG CTCCCGGGGG ACCCAAGCAA CAAGCAGGGG AGGCTGTAAA
961  GAGGCCGTCG GGCAGGGGCC CATGGTGGAG ACCCCTCTAT TACGTGCAGA CCCACGACCT CGTTAGCAGG GTCACGCGCA
1041  GACCCACGAC CTCGTTAGTG AGCAGGGGTG CAGGGGTGGG GTCTGGCCGG AGGCTGGTCA GCTCCCAGGT GCAAAGACCC
1121  TGAGTCCTGA GAACTCGCCC AGGTGAGAAG TGGGGAGGAG GCCAGGTGAG GAGGGGGTGG GAGGCCAGGT GGGGGGGGGA
1201  GCGGGAGGCT AGGTGGGGGG GGCTGGAGGC CAGGTGAGGG GGGGCGGGAG GCCAGGTGGG GGGGGCGGGA GACCAGGAGA
1281  GGAGGGGACG GGAGGCCAGG AGAGGAGGGG GCGGGAGGCC AGGAGAGGAG GGGGCGGGAG GCCAGGTGAG GAGGGGGCGG
1361  GAGGCCAGGT GAGGGGGGGG CGGGAGGCCA GGTGAGGGGG GTGCGGGAGG CCAGGTGAGG ACGGGGTGGG AGGCCAGGTG
1441  AGGGGGGGGC GGGAGGCCAG GTGAGGAGGG GGCGGGAGGC CAGGTGAGGA GGGGGCGGGA GGCCAGGTGA GGGGGGGGGC
1521  GGGAGGCCAG GTGAGGAGGG GGCGGGAGGC CAGGTGAGGA GGGGGCGGGA GGCCAGGTGA GGGGGGGGGC GGGAGGCCAG
1601  GTGGTTGGAG GGGCAGGTGG GGCAGTGCTT CCAGGTGTGC GGAAGTGGAG GGGGTGGACC CCAGGGGCTC CATGCTGGGC
1681  CGTGGTCTTC TGTGTGGGGT TTGTGTTCCA GTGACCTGAG GGAGTCAGAC ACACAAAGGG CGCAGGTCAC CTGGAGCTTC
1761  TGCAAGCTCC ACCTGGAAGT CCACAGTCCA GGGCTGGCCC ACACCCCGCA GCCGGGAGTT AGTGCGCGCG AGTGGCTGTG
1841  TGTGCGTGCG TGTGAGCGTG TGGGCAAGTG AGCACACATG CGCGTGTGTG TTCAGGTGTG CGGGTGAACT GTGCGCATGT
1921  GTGGGGGTTT GTGACTGTGT GTGTGTGAGC GTGCGTCACA CATGGGTGTG TGCAGGCAGC TCTGGGCAGC CATCCTGCTC
2001  AGCTGCCCTC CCCAGCTCCA CCCTAGGCTC TGACCCCTAG ACTCGGGCCA CTCAGGGCAG GGTGTGGTAG CGCCTGCCCC
2081  TGCCCCCGCC GGGTCCTCAG GGGCCTGTCC TGGCCTTTCG GGACATTCAG GGCGTCTGGG TCAGCGACAG CTCCTGAGAG
2161  CAGCTGTGGT CAGGGCTGGG AGCTTGAGGT GGCAGGCAAG GGCGGCTGGG GTTCCAGGCG GGCAGGCTGG GGCCAGCGTG
2241  GGGTCCACGT GGGGTGGGCC CAGGTCCGCG TGTTCTCAGA CTCCTCCCCT GCAGGTGGTT CTTTGGCTGC ATCTCCCGCT
2321  CGGAAGCTGT GCGTCGGCTG CAGGCCGAGG GCAACGCCAC GGGCGCCTTC CTGATCAGGG TCAGCGAGAA GCCGAGTGCC
2401  GACTACGTCC TGTCGGGTGC GGCCCCGGCC TCCGAGCCTG TGCTTGCCTG CGGGGGCTCC TGGCTCTAAG CCCTCCCAGC
2481  CACGTGGTGA ACCCGGCTCG CTCTGGCTGA GACGGGGGAC ATGGGCTCCT CTCCAGGGAG CTCCCATCCC CTCCGCCCAC
2561  CTGGCCCGCT CCTCCCTGGG GCCTGGGTCA CTGGCTGCTA GGGTAGTCGT GGGGCAGGGC CCCTCCCTGG GAGGGCAGGG
2641  GCTTCTCCAG CCAGCCCTGC CCGAGGCACT CGTGGGAGGT CCTCAGCACC CATGGGAACC TCGCCCAGCA TGAGACCTGA
2721  GCCTGGGGTG TGCGGGGCGC AGAGAAACCC CATCCCTGCC CCTGAGGATC TCAGCATGGC TGGGATTTTA GGCAGCTGCC
2801  ATCCAGGCGG AGGCCACTGG CTGCCTGGCA CGGGGGCAGG AGGGGCCAGA GAGCTTGGCC AGAGCGTGCA GGGCAGGAGG
2881  GAGCCGTTCT GAGGGAGGGG AGGCAGGGGT GGTACTGAGG AAGCACCAAC AGCAACTGTG GGGACCCAGA AACTCTGCGC
2961  AGGTGTGGCC AGCAGGGCTG GGGACGCAGG GAGGCGTCGG AGTTGGGGTG GCCACACAGC TCACGCTCTC CCTCCCAGTG
3041  CGGGACACGC AGGCTGTGCG GCACTACAAG ATCTGGCGGC GTGCCGGGGG CCGGCTGCAC CTGAACGAGG CGGTGTCCTT
3121  CCTCAGCCTG CCCGAGCTTG TGAACTACCA CAGGGCCCAG AGCCTGTCCC ACGGCCTGCG GCTGGCCGCG CCCTGCCGGA
3201  AGGTAGCCGC TCCGCCCTGA CTTGGTCACG CGGGGTCAGG CTGGGGGGTC ACAGGCTGGC ATTTCCTACT GGGAGAGGTT
3281  GGCCGGGCAG CATGGGAGGG GTCCTGACTC ACTGACCTGG GGCCCACTGG AGGGAAGCCC ATGGTTCTGC AGAGCACAGG
3361  TGTTTGCCTG AGTTGGGGGT GGGGCCAGGA GACCATCCCC GGGCCTGGCC ACTCTCGGAG AGGCCAGCGG CACTCTGCAG
3441  GGTCCTGGCT CCGGTCTGTC TGGGTGTTTC ATGCTGGGCT GGGGGCAGCC CCCAGGAGAG TCCACCCTTG TGTCAGACAC
3521  TCAGAAACCC CCAACCCAGG CTGATCGTGG CCCTAAATCT GAGGCTAAAT CCAGGCTCCC TGTGCTGGCT TCAGACTGGC
3601  ACTTCCTGAA GGATGAGCCC CTGCCCTGTG TCCCCGACTC TTCCTCCAGC ACGAGCCTGA GCCCCTGCCC CATTGGGATG
3681  ACTGGGAGAG GCCGAGGGAG GAGTTCACGC TCTGCAGGAA GCTGGGGTCC GGCTACTTTG GGGAGGTCTT CGAGGGGCTC
3761  TGGAAAGACC GGGTCCAGGT GGCCATTAAG GTGATTTCTC GAGGTGAGTG GGCCCCGATC AGGGCTCTGT GTGGCCCCGT
3841  GCCTGCCCTG GGCCACCCTC CCACCCCGCC AACAGGGACC TCTGGCCTCG AGCCCCAAGC AGCACCCACA GCGTCCATGC
3921  GAGAGTGGTT CCCTTTCAAT TGCACCTATG TTTTTACCTA AATACATTTA TTATAAAAGA AAATTTTAGG CCGGGCACGG
4001  TGGCTCACAT CTGTAATCCC CACACTTTGG GAAGCCAAGG TGGGCGGATC ACGAGGTCAG GAGTTTGAGA CCAGCCTGGC
4081  CAACATGGGG AAACCACGTC TCTACTAAAA ATACAAAAAT TAGCCGAGTG TGGAGGCATG TGCCTGTAGT CCCAGCTACT
4161  CGGGAGGCTG AGGCAGGAGA ATCGCTTCAA CCCAGGAGGC GGAGATTGCA GTGAGCTGAG ATCGCGCCAT TGCACTCCAG
4241  CCTGGGCGAC AGAGCAAGAC CCCGTCTTGG GAAAAAAAAA AAAGAAAGAA AGAAAGAAAA TTTAAAATCC TTGACGTAAT
4321  GGAAAGCCAT TAAAATAGAT CACTGGAAAT GGGTAAAACT TCCCTGGAAC CCGTCTGGGC CCCAGCAGAG GTCTGGCCTC
4401  TATGTCAGAG GTCTGGGCCG GGCACAGGAA GAAATCGGGT GGCCACCACA GCCCCGTGGG TACGCCAGGC TGGGGCCCTG
4481  TGGGGCCGGC TGCATCTGCC ATTTCGTGGC CTCGGGAGCC AGGTGCCCTG TCGGGGGCAG GAGGTCTGTG TGTCCTGCAC
4561  AGCTGCTGGG TGTGATGGCT GCTGTGTGTG GGGGCAGGGC CTTGGCCTCT TCCTTGGGGC CTGGGGGGTC AGGGGCTGCA
4641  TCCACCGAGG CCACCCGTCC CCGCAGACAA CCTCCTGCAC CAGCAGATGC TGCAGTCGGA GATCCAGGCC ATGAAGAAGC
4721  TGCGGCACAA ACACATCCTG GCGCTGTACG CCGTGGTGTC CGTGGGGGAC CCCGTGTACA TCATCACGGA GCTCATGGCC
4801  AAGGGCAGCC TGCTGGAGCT GCTCCGCGGT GAGTGGCATG GGCCGGGGCT CTTGCTGGAG GCAGCGGGGG CACGTGAGGA
4881  AATAAAGTGC ACACCCCCCC CCCACGTCTA CACACACACA CACGTAGACA CACAGACACA CAGACACACA CATGCACACA
4961  CAGACACAGA CACAGACACA CAGAGACACA CACGCACAGA CACACATGCA CACACACATG CACACAGACA TACACATGCA
5041  CACACAGACA CACACACAAG ACACATCACA TGACACACAC AGACATACAC ATAGACACAG ACACACACAC AGAGACACAC
5121  AAAACAGATC ACACGGACAC ACACAGACAC ACACACAGAT CACACGGACA CACACAGACA CACACACACA CAGACACACA
5201  CTGATCCAGA CACACACACA GACACACACA GATCACATTG GCTCAAAGAC TTCATCCTCT CTAAGTTCCA TTATTTCCTT
5281  TCTCACCAAA ACCAAAGACA ATCGCTGCCA GGGAATGGAG ATGCCCGTGC GTGAAGGCGC AGTTTGGATT CCGATGTTAG
5361  AATGGGAGGG AACGTTGTGG TATAGGAAAA ATGCCGTGTG TGTCTGAGGA GAGCTACACT GAGGCACCAC GCACGTTTGC
5441  GCTCTGAGCG AAAGGCTCCG TACCCCTCGC CCTCACACAA AGGGCTTGAT CATCTCAGAC AGTCCCCACG CCCTTCAGGG
5521  TCCTCCGGGA GGGAATGTGG GGTAAAACAG GCACCACCAG GCCGCAAGCC GCTGACAGCC ATTCTCCTGT TCGAGTTCCC
5601  ACTGCCTACA TCACGCAGTC ATGAGCCTCT TCGCTGGTCC TTCTGCGTCC AGCTCCTCCC GCGTCATCAC AAACTTCCAG
5681  AAGGGAAATC GCTGGGCTAG ACCACTAGGA ACTGCTCCTT GGTTCTTTTT TTTTTTTTTG AGACGGAGTC TCACTCTGTC
5761  GCCCAGGCTG GAGTGCAATG GCGCAGTCTC GGCTCACTGT AACCTCCACC TCCTGGGTTC AAATGATTCT CCTGCCTCAG
5841  CCACCTGAGT AGCTGAGATT ACAGGCACCT GTCACCACGC CCAGCTAATT ATATATATAT ATATATATAT ATATATTTTT
5921  TTTTTTTTTT TTTGAGACGG AGTCTGGCTC TGTCGCCCAG GCTGGAGTGC AGTGGCGTGA TCTCGGCTCA CTGCAAGCTC
6001  CGCCTCCCGG GTTCACGCCA TTCTCCTGCC TCAGCCTCCC GAGTAGCTGG GACTACAGGC GCCCGCCACC ACGCCCGGCT
6081  AATTTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCGTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC GTGATCCATC
6161  CGCCTCAGCC TCTCAAAGTG CTGGGATTAC AGGCGTGAGC CACCACGCCC AGCTTGCTCC TTGGTTCGTG ATAAACAGTT
6241  GCCTTCCAGA AGGGCGGTAG CTGGCCTGCA GTTCCAATTT TCAATCAGGC CAGCTGCCCT TTGCCCCGGC CCCTCCTCTG
6321  AGCCCGCAGA GCTTGGAGGC AGATGAGACA TGGCCCAGCC TCCCCAACCC TTCCCCACCT CAGCTGGCTC AGCTGACCCC
6401  AGGCTCTGCT CCACTCCCCT CTGCAGACTC TGATGAGAAA GTCCTGCCCG TTTCGGAGCT GCTGGACATC GCCTGGCAGG
6481  TGGCTGAGGG CATGTGTTAC CTGGAGTCGC AGAATTACAT CCACCGGGAC CTGGCCGCCA GGAACATCCT CGTCGGGGAA
6561  AACACCCTCT GCAAAGTTGG GGACTTCGGG TTAGCCAGGC TTATCAAGGT AGGGCCCTCA GAGGGCGTGG CTGGGGTCGT
6641  GGCCGGGGCG TGGCCGGAGG GCTGGGGGCT TCCTGTGTGT GGAGCTGGGG ACTCGGCTGG GAGCAGGATG CGGCCCCTGC
6721  CCTCGGGAGC CCAGGCTGGG CAGGGAGGTG GGAAGCCACC GTGAGTCCGG TGGGGCCCCC ATTCTGAATG GCACGCACAG
6801  CAGGGCCCAC CACGCAGCCG CTGCCTTGTT CACGTGCCTT GTTCACTGGC CCAGCCCTGG GCCCCTCTGA CGGCCTGGGA
6881  GCCTCCCAGT TCCCTGTCCC CCGGGCCCTC CGGTCCCCAC ACACCTGCAA TCCCAGGGGA AGTTGGGCTC CTGAAGGTGG
6961  TCAGGCCCCA GTGTGGCCTT AGCTGCAGCG GCCGTGCGTG GGTCAGACAG TGGGGTCATC ACCGTCCCAC TGCTGGGGCA
7041  ATGCGGCCGC TGTGCCCGTC CATGCTTCGG GGGCAGGGCA CAGGCAGCCC CCACGGCCCA CTCAGCTCCA GGCTGATTGC
7121  AGGAGGACGT CTACCTCTCC CATGACCACA ATATCCCCTA CAAGTGGACG GCCCCTGAAG CGCTCTCCCG AGGCCATTAC
7201  TCCACCAAAT CCGACGTCTG GTCCTTTGGG ATTCTCCTGC ATGAGATGTT CAGCAGGGGT CAGGTGCCCT ACCCAGGTAC
7281  TGTCCCCACT GTCCCTGACT GGGCATGAGA GGCAGAGTGG GGGAGGTCCT GGGTAGCCGG CAGGGACGCT GGGGGGTGCC
7361  TCCCCCACGG GCTTCAGGGC CCTCCGCGGG CCATCGCCTG AACTCCACAC CTGCACCATT CTCTGAGCAC CCAGGCTGGT
7441  GCCTGGAGCT GCCTGTTGGA GCCCTGTCCA GAGGGAGGTG TTAGCAGTGG ACAGTGTGCT GGGTGGCGCC AAGGCATGGC
7521  AGCTGAGGCT GCGGGGAAGG CCCCAGGAAG GGGCAGTGGA TGGCTGGTGT GGCTTCTTGG GGGAGGGTAG GCAGGTGGGC
7601  CCCAGCTCTT CTCATCCCTG TCGGCCGCAG GCATGTCCAA CCATGAGGCC TTCCTGAGGG TGGACGCCGG CTACCGCATG
7681  CCCTGCCCTC TGGAGTGCCC GCCCAGCGTG CACAAGCTGA TGCTGACATG CTGGTGCAGG GACCCCGAGC AGAGACCCTG
7761  CTTCAAGGCC CTGCGGGAGA GGCTCTCCAG CTTCACCAGC TACGAGAACC CGACCTGAGC TGCTGTGGAG CGGGCATGGC
7841  CGGGCCCTGC TGAGGAGGGG CCTGGGCAGA GGGCCTGGAC CTGGGATCAA GGCCCACGCG CTTCCCTGGG GTTTACTGAG
7921  GTGATGGGTG CAGGAAAGGT TCACAAATGT GGAGTGTCTG CGTCCAATAC ACGCGTGTGC TCCTCTCCTT ACTCCATCGT
8001  GTGTGCCTTG GGTCTCAGCT GCTGACACGC AGCCTGCTCT GGAGCCTGCA GATGAGATCC GGGAGACTGA CACGAAGCCA
8081  GCAGAGGTCA GAGGGGACTC TGACCACAGC CCGCTCTCTG GCTGTCTGTC TGCAGTGCCC GGCTGAGGGT GGGAGGCAAA
8161  CACGCCTTGT TCCTGCTCTT CCCAGTTCAG CTTGGTGGGA GAAAGTCATT CGCGTGGCTC GGGACGCTCA TGTAAATTTG
8241  GTTTTGGTGC TCAAGGGTTC TTTCCTCCCA GGGGCAGGTG TTTCTTTCCT GTTTGTCTTG TGTCTTGAGA GCTTGGCCTT
8321  ATGACCAGTG AGAACTCTCT CCCTGGTCTC TGCCAGCCCA AGCATCACTG CCCGAGGCGC CAGCTCAGTT TCACCGTCCA
8401  CGTCCACAAG GGGCTTTTCC CACCTTCACC TTTGTCGCTG GGTCAGTGCT GGAAAGCGCC CCTCACTCCT GCGCTGACAA
8481  GGGCCCTTCT CTACTGTCTG TGGGGTGGTT CCGGGCTGGG GGGGCTGCCT CCTTTGCACC TGATTTTGAA GGTGTCTCTT
8561  TCATCCATGG TTAAGTCATA AAAAGCTTAT TGGTTTTGGT TTTGACTCAC CTGAAAGTTT TTTTGGTTTA AAAGAAGAAT
8641  AGGCGGGGCA CGGTGGCTCA TGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG
8721  ACACCATCCT GGCTAACACG GTGAAACCCC GTCTCTACTA AAAAATACAA AAAATTAGCT GGGTGTGGTG GTGGGGGTGG
8801  GCGCCTGTAG TCCCAGCTAC GTGGGAGGCT GAGGCAGCAG ACTGGTGTGA ACCCGGGAGG TGGAGCTTGC AGTGAGCCGA
8881  GATCGCGCCA CTGCACTCCA GCCTGGGCGA CAGAGCGAGA CTCCATCTCA AAAAAAAAAA AA
>ref|Gene_ID:5753|PTK6|NC_000020.10:62159765...62168706 (-)
CTGGGCCACAGCCTGGTCCTGCCGCTGCGCCCGCCCGCCATGGTGTCCCGGGACCAGGCTCACCTGGGCCCCAAGTATGT
GGGCCTCTGGGACTTCAAGTCCCGGACGGACGAGGAGCTGAGCTTCCGCGCGGGGGACGTCTTCCACGTGGCCAGGAAGG
AGGAGCAGTGGTGGTGGGCCACGCTGCTGGACGAGGCGGGTGGGGCCGTGGCCCAGGGCTATGTGCCCCACAACTACCTG
GCCGAGAGGGAGACGGTGGAGTCGGAACCGTGCGTGTCCTAGGCTGCTGGGAGCTTTGGCACAGGCCACCCTCTAGGCAC
AGGGGAGGGACAGGGCTCTGGGCTGCTCAGGGAGGCCCAAGAAGGTGGGGACCCCGGTTCCATCTTCCTGCACCCCAAAG
TCCAGGCTGGGCATCCCGCTTGATCCTCCCTGCAGGCCCCATGCGCTGGCGCCCAGGAGTGCCCAGGACTGTCCCTGCGG
GAGTTGGAGCACGGGGGTCAGAGGGCACGGCCCCTGCCTTGGGCTCATCCTTGTCACAGCTCGGGGGTGGACGCTGCATT
GCCGGGACCCAGGGAGGACAGAGGGTCCAGGGTGGACTTCTGGGGCCCGGTGGCCAGTGACAAGGTCTGTCGGAGCGTTC
CAGGGCCTTTGGGGGAAACGAAGCTTGAAGCTTGCCCAGTTTCCAAAGTGCCGGAACCAGACACACGACCTAGTTAGGGG
AGCGGGCCGGCTGCCGGGCAAACTTCCTGCCTGCTGTGCCCTGCGGGGAACCAGACAGCAGCTGGTGTGGCCTGGCCCTG
GCTTCCACAGCTGCCCGGAGCTCAGGCTGAGGAGGGTCACGCTCCTGAGATCCCGCGTTTCTCATCAGTGATTGGGCACC
CACTGTGTGTGTGCGTGAGTCACAGGCTGTGTAGGGTTAGCTCCCGGGGGACCCAAGCAACAAGCAGGGGAGGCTGTAAA
GAGGCCGTCGGGCAGGGGCCCATGGTGGAGACCCCTCTATTACGTGCAGACCCACGACCTCGTTAGCAGGGTCACGCGCA
GACCCACGACCTCGTTAGTGAGCAGGGGTGCAGGGGTGGGGTCTGGCCGGAGGCTGGTCAGCTCCCAGGTGCAAAGACCC
TGAGTCCTGAGAACTCGCCCAGGTGAGAAGTGGGGAGGAGGCCAGGTGAGGAGGGGGTGGGAGGCCAGGTGGGGGGGGGA
GCGGGAGGCTAGGTGGGGGGGGCTGGAGGCCAGGTGAGGGGGGGCGGGAGGCCAGGTGGGGGGGGCGGGAGACCAGGAGA
GGAGGGGACGGGAGGCCAGGAGAGGAGGGGGCGGGAGGCCAGGAGAGGAGGGGGCGGGAGGCCAGGTGAGGAGGGGGCGG
GAGGCCAGGTGAGGGGGGGGCGGGAGGCCAGGTGAGGGGGGTGCGGGAGGCCAGGTGAGGACGGGGTGGGAGGCCAGGTG
AGGGGGGGGCGGGAGGCCAGGTGAGGAGGGGGCGGGAGGCCAGGTGAGGAGGGGGCGGGAGGCCAGGTGAGGGGGGGGGC
GGGAGGCCAGGTGAGGAGGGGGCGGGAGGCCAGGTGAGGAGGGGGCGGGAGGCCAGGTGAGGGGGGGGGCGGGAGGCCAG
GTGGTTGGAGGGGCAGGTGGGGCAGTGCTTCCAGGTGTGCGGAAGTGGAGGGGGTGGACCCCAGGGGCTCCATGCTGGGC
CGTGGTCTTCTGTGTGGGGTTTGTGTTCCAGTGACCTGAGGGAGTCAGACACACAAAGGGCGCAGGTCACCTGGAGCTTC
TGCAAGCTCCACCTGGAAGTCCACAGTCCAGGGCTGGCCCACACCCCGCAGCCGGGAGTTAGTGCGCGCGAGTGGCTGTG
TGTGCGTGCGTGTGAGCGTGTGGGCAAGTGAGCACACATGCGCGTGTGTGTTCAGGTGTGCGGGTGAACTGTGCGCATGT
GTGGGGGTTTGTGACTGTGTGTGTGTGAGCGTGCGTCACACATGGGTGTGTGCAGGCAGCTCTGGGCAGCCATCCTGCTC
AGCTGCCCTCCCCAGCTCCACCCTAGGCTCTGACCCCTAGACTCGGGCCACTCAGGGCAGGGTGTGGTAGCGCCTGCCCC
TGCCCCCGCCGGGTCCTCAGGGGCCTGTCCTGGCCTTTCGGGACATTCAGGGCGTCTGGGTCAGCGACAGCTCCTGAGAG
CAGCTGTGGTCAGGGCTGGGAGCTTGAGGTGGCAGGCAAGGGCGGCTGGGGTTCCAGGCGGGCAGGCTGGGGCCAGCGTG
GGGTCCACGTGGGGTGGGCCCAGGTCCGCGTGTTCTCAGACTCCTCCCCTGCAGGTGGTTCTTTGGCTGCATCTCCCGCT
CGGAAGCTGTGCGTCGGCTGCAGGCCGAGGGCAACGCCACGGGCGCCTTCCTGATCAGGGTCAGCGAGAAGCCGAGTGCC
GACTACGTCCTGTCGGGTGCGGCCCCGGCCTCCGAGCCTGTGCTTGCCTGCGGGGGCTCCTGGCTCTAAGCCCTCCCAGC
CACGTGGTGAACCCGGCTCGCTCTGGCTGAGACGGGGGACATGGGCTCCTCTCCAGGGAGCTCCCATCCCCTCCGCCCAC
CTGGCCCGCTCCTCCCTGGGGCCTGGGTCACTGGCTGCTAGGGTAGTCGTGGGGCAGGGCCCCTCCCTGGGAGGGCAGGG
GCTTCTCCAGCCAGCCCTGCCCGAGGCACTCGTGGGAGGTCCTCAGCACCCATGGGAACCTCGCCCAGCATGAGACCTGA
GCCTGGGGTGTGCGGGGCGCAGAGAAACCCCATCCCTGCCCCTGAGGATCTCAGCATGGCTGGGATTTTAGGCAGCTGCC
ATCCAGGCGGAGGCCACTGGCTGCCTGGCACGGGGGCAGGAGGGGCCAGAGAGCTTGGCCAGAGCGTGCAGGGCAGGAGG
GAGCCGTTCTGAGGGAGGGGAGGCAGGGGTGGTACTGAGGAAGCACCAACAGCAACTGTGGGGACCCAGAAACTCTGCGC
AGGTGTGGCCAGCAGGGCTGGGGACGCAGGGAGGCGTCGGAGTTGGGGTGGCCACACAGCTCACGCTCTCCCTCCCAGTG
CGGGACACGCAGGCTGTGCGGCACTACAAGATCTGGCGGCGTGCCGGGGGCCGGCTGCACCTGAACGAGGCGGTGTCCTT
CCTCAGCCTGCCCGAGCTTGTGAACTACCACAGGGCCCAGAGCCTGTCCCACGGCCTGCGGCTGGCCGCGCCCTGCCGGA
AGGTAGCCGCTCCGCCCTGACTTGGTCACGCGGGGTCAGGCTGGGGGGTCACAGGCTGGCATTTCCTACTGGGAGAGGTT
GGCCGGGCAGCATGGGAGGGGTCCTGACTCACTGACCTGGGGCCCACTGGAGGGAAGCCCATGGTTCTGCAGAGCACAGG
TGTTTGCCTGAGTTGGGGGTGGGGCCAGGAGACCATCCCCGGGCCTGGCCACTCTCGGAGAGGCCAGCGGCACTCTGCAG
GGTCCTGGCTCCGGTCTGTCTGGGTGTTTCATGCTGGGCTGGGGGCAGCCCCCAGGAGAGTCCACCCTTGTGTCAGACAC
TCAGAAACCCCCAACCCAGGCTGATCGTGGCCCTAAATCTGAGGCTAAATCCAGGCTCCCTGTGCTGGCTTCAGACTGGC
ACTTCCTGAAGGATGAGCCCCTGCCCTGTGTCCCCGACTCTTCCTCCAGCACGAGCCTGAGCCCCTGCCCCATTGGGATG
ACTGGGAGAGGCCGAGGGAGGAGTTCACGCTCTGCAGGAAGCTGGGGTCCGGCTACTTTGGGGAGGTCTTCGAGGGGCTC
TGGAAAGACCGGGTCCAGGTGGCCATTAAGGTGATTTCTCGAGGTGAGTGGGCCCCGATCAGGGCTCTGTGTGGCCCCGT
GCCTGCCCTGGGCCACCCTCCCACCCCGCCAACAGGGACCTCTGGCCTCGAGCCCCAAGCAGCACCCACAGCGTCCATGC
GAGAGTGGTTCCCTTTCAATTGCACCTATGTTTTTACCTAAATACATTTATTATAAAAGAAAATTTTAGGCCGGGCACGG
TGGCTCACATCTGTAATCCCCACACTTTGGGAAGCCAAGGTGGGCGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGC
CAACATGGGGAAACCACGTCTCTACTAAAAATACAAAAATTAGCCGAGTGTGGAGGCATGTGCCTGTAGTCCCAGCTACT
CGGGAGGCTGAGGCAGGAGAATCGCTTCAACCCAGGAGGCGGAGATTGCAGTGAGCTGAGATCGCGCCATTGCACTCCAG
CCTGGGCGACAGAGCAAGACCCCGTCTTGGGAAAAAAAAAAAAGAAAGAAAGAAAGAAAATTTAAAATCCTTGACGTAAT
GGAAAGCCATTAAAATAGATCACTGGAAATGGGTAAAACTTCCCTGGAACCCGTCTGGGCCCCAGCAGAGGTCTGGCCTC
TATGTCAGAGGTCTGGGCCGGGCACAGGAAGAAATCGGGTGGCCACCACAGCCCCGTGGGTACGCCAGGCTGGGGCCCTG
TGGGGCCGGCTGCATCTGCCATTTCGTGGCCTCGGGAGCCAGGTGCCCTGTCGGGGGCAGGAGGTCTGTGTGTCCTGCAC
AGCTGCTGGGTGTGATGGCTGCTGTGTGTGGGGGCAGGGCCTTGGCCTCTTCCTTGGGGCCTGGGGGGTCAGGGGCTGCA
TCCACCGAGGCCACCCGTCCCCGCAGACAACCTCCTGCACCAGCAGATGCTGCAGTCGGAGATCCAGGCCATGAAGAAGC
TGCGGCACAAACACATCCTGGCGCTGTACGCCGTGGTGTCCGTGGGGGACCCCGTGTACATCATCACGGAGCTCATGGCC
AAGGGCAGCCTGCTGGAGCTGCTCCGCGGTGAGTGGCATGGGCCGGGGCTCTTGCTGGAGGCAGCGGGGGCACGTGAGGA
AATAAAGTGCACACCCCCCCCCCACGTCTACACACACACACACGTAGACACACAGACACACAGACACACACATGCACACA
CAGACACAGACACAGACACACAGAGACACACACGCACAGACACACATGCACACACACATGCACACAGACATACACATGCA
CACACAGACACACACACAAGACACATCACATGACACACACAGACATACACATAGACACAGACACACACACAGAGACACAC
AAAACAGATCACACGGACACACACAGACACACACACAGATCACACGGACACACACAGACACACACACACACAGACACACA
CTGATCCAGACACACACACAGACACACACAGATCACATTGGCTCAAAGACTTCATCCTCTCTAAGTTCCATTATTTCCTT
TCTCACCAAAACCAAAGACAATCGCTGCCAGGGAATGGAGATGCCCGTGCGTGAAGGCGCAGTTTGGATTCCGATGTTAG
AATGGGAGGGAACGTTGTGGTATAGGAAAAATGCCGTGTGTGTCTGAGGAGAGCTACACTGAGGCACCACGCACGTTTGC
GCTCTGAGCGAAAGGCTCCGTACCCCTCGCCCTCACACAAAGGGCTTGATCATCTCAGACAGTCCCCACGCCCTTCAGGG
TCCTCCGGGAGGGAATGTGGGGTAAAACAGGCACCACCAGGCCGCAAGCCGCTGACAGCCATTCTCCTGTTCGAGTTCCC
ACTGCCTACATCACGCAGTCATGAGCCTCTTCGCTGGTCCTTCTGCGTCCAGCTCCTCCCGCGTCATCACAAACTTCCAG
AAGGGAAATCGCTGGGCTAGACCACTAGGAACTGCTCCTTGGTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTC
GCCCAGGCTGGAGTGCAATGGCGCAGTCTCGGCTCACTGTAACCTCCACCTCCTGGGTTCAAATGATTCTCCTGCCTCAG
CCACCTGAGTAGCTGAGATTACAGGCACCTGTCACCACGCCCAGCTAATTATATATATATATATATATATATATATTTTT
TTTTTTTTTTTTTGAGACGGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTC
CGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCT
AATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCATC
CGCCTCAGCCTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGCTTGCTCCTTGGTTCGTGATAAACAGTT
GCCTTCCAGAAGGGCGGTAGCTGGCCTGCAGTTCCAATTTTCAATCAGGCCAGCTGCCCTTTGCCCCGGCCCCTCCTCTG
AGCCCGCAGAGCTTGGAGGCAGATGAGACATGGCCCAGCCTCCCCAACCCTTCCCCACCTCAGCTGGCTCAGCTGACCCC
AGGCTCTGCTCCACTCCCCTCTGCAGACTCTGATGAGAAAGTCCTGCCCGTTTCGGAGCTGCTGGACATCGCCTGGCAGG
TGGCTGAGGGCATGTGTTACCTGGAGTCGCAGAATTACATCCACCGGGACCTGGCCGCCAGGAACATCCTCGTCGGGGAA
AACACCCTCTGCAAAGTTGGGGACTTCGGGTTAGCCAGGCTTATCAAGGTAGGGCCCTCAGAGGGCGTGGCTGGGGTCGT
GGCCGGGGCGTGGCCGGAGGGCTGGGGGCTTCCTGTGTGTGGAGCTGGGGACTCGGCTGGGAGCAGGATGCGGCCCCTGC
CCTCGGGAGCCCAGGCTGGGCAGGGAGGTGGGAAGCCACCGTGAGTCCGGTGGGGCCCCCATTCTGAATGGCACGCACAG
CAGGGCCCACCACGCAGCCGCTGCCTTGTTCACGTGCCTTGTTCACTGGCCCAGCCCTGGGCCCCTCTGACGGCCTGGGA
GCCTCCCAGTTCCCTGTCCCCCGGGCCCTCCGGTCCCCACACACCTGCAATCCCAGGGGAAGTTGGGCTCCTGAAGGTGG
TCAGGCCCCAGTGTGGCCTTAGCTGCAGCGGCCGTGCGTGGGTCAGACAGTGGGGTCATCACCGTCCCACTGCTGGGGCA
ATGCGGCCGCTGTGCCCGTCCATGCTTCGGGGGCAGGGCACAGGCAGCCCCCACGGCCCACTCAGCTCCAGGCTGATTGC
AGGAGGACGTCTACCTCTCCCATGACCACAATATCCCCTACAAGTGGACGGCCCCTGAAGCGCTCTCCCGAGGCCATTAC
TCCACCAAATCCGACGTCTGGTCCTTTGGGATTCTCCTGCATGAGATGTTCAGCAGGGGTCAGGTGCCCTACCCAGGTAC
TGTCCCCACTGTCCCTGACTGGGCATGAGAGGCAGAGTGGGGGAGGTCCTGGGTAGCCGGCAGGGACGCTGGGGGGTGCC
TCCCCCACGGGCTTCAGGGCCCTCCGCGGGCCATCGCCTGAACTCCACACCTGCACCATTCTCTGAGCACCCAGGCTGGT
GCCTGGAGCTGCCTGTTGGAGCCCTGTCCAGAGGGAGGTGTTAGCAGTGGACAGTGTGCTGGGTGGCGCCAAGGCATGGC
AGCTGAGGCTGCGGGGAAGGCCCCAGGAAGGGGCAGTGGATGGCTGGTGTGGCTTCTTGGGGGAGGGTAGGCAGGTGGGC
CCCAGCTCTTCTCATCCCTGTCGGCCGCAGGCATGTCCAACCATGAGGCCTTCCTGAGGGTGGACGCCGGCTACCGCATG
CCCTGCCCTCTGGAGTGCCCGCCCAGCGTGCACAAGCTGATGCTGACATGCTGGTGCAGGGACCCCGAGCAGAGACCCTG
CTTCAAGGCCCTGCGGGAGAGGCTCTCCAGCTTCACCAGCTACGAGAACCCGACCTGAGCTGCTGTGGAGCGGGCATGGC
CGGGCCCTGCTGAGGAGGGGCCTGGGCAGAGGGCCTGGACCTGGGATCAAGGCCCACGCGCTTCCCTGGGGTTTACTGAG
GTGATGGGTGCAGGAAAGGTTCACAAATGTGGAGTGTCTGCGTCCAATACACGCGTGTGCTCCTCTCCTTACTCCATCGT
GTGTGCCTTGGGTCTCAGCTGCTGACACGCAGCCTGCTCTGGAGCCTGCAGATGAGATCCGGGAGACTGACACGAAGCCA
GCAGAGGTCAGAGGGGACTCTGACCACAGCCCGCTCTCTGGCTGTCTGTCTGCAGTGCCCGGCTGAGGGTGGGAGGCAAA
CACGCCTTGTTCCTGCTCTTCCCAGTTCAGCTTGGTGGGAGAAAGTCATTCGCGTGGCTCGGGACGCTCATGTAAATTTG
GTTTTGGTGCTCAAGGGTTCTTTCCTCCCAGGGGCAGGTGTTTCTTTCCTGTTTGTCTTGTGTCTTGAGAGCTTGGCCTT
ATGACCAGTGAGAACTCTCTCCCTGGTCTCTGCCAGCCCAAGCATCACTGCCCGAGGCGCCAGCTCAGTTTCACCGTCCA
CGTCCACAAGGGGCTTTTCCCACCTTCACCTTTGTCGCTGGGTCAGTGCTGGAAAGCGCCCCTCACTCCTGCGCTGACAA
GGGCCCTTCTCTACTGTCTGTGGGGTGGTTCCGGGCTGGGGGGGCTGCCTCCTTTGCACCTGATTTTGAAGGTGTCTCTT
TCATCCATGGTTAAGTCATAAAAAGCTTATTGGTTTTGGTTTTGACTCACCTGAAAGTTTTTTTGGTTTAAAAGAAGAAT
AGGCGGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACGAGGTCAGGAGATCG
ACACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAATTAGCTGGGTGTGGTGGTGGGGGTGG
GCGCCTGTAGTCCCAGCTACGTGGGAGGCTGAGGCAGCAGACTGGTGTGAACCCGGGAGGTGGAGCTTGCAGTGAGCCGA
GATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCATCTCAAAAAAAAAAAAA