BAX, mRNA isoform alpha - Generality top
	Primary source RefSeq : NM_138761.3 (GI:163659848) Name BCL2-associated X protein (BAX), transcript variant alpha Type of transcript mRNA Organism Homo sapiens Length 888 nt Map 19q13.3-q13.4 Location Chromosome 19 (NC_000019.9)  strand : + 49458116...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49464066...49464170   49464788...49465054
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 103 103 1 Exon 2 104 155 52 1 Exon 3 156 302 147 1 Exon 4 303 438 136 1 Exon 6c 439 543 105 1 Exon 8a 544 810 267 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source rs1057369 SNP 621 a/g 1 ? dbSNP rs704243 SNP 726 a/g 1 ? dbSNP rs72215802 insertion 762 -/g 1 ? dbSNP
	CDS top
	Primary source NCBI : CCDS12742 Nucleotide BAX, mRNA isoform alpha[NM_138761.3] : 70...648 Length 579 Location Chromosome 19 (NC_000019.9)  strand : + 49458185...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49464066...49464170   49464788...49464892   Start codon 1 Translation NP_620116.1
	Sequence top
	FASTA 1  TCACGTGACC CGGGCGCGCT GCGGCCGCCC GCGCGGACCC GGCGAGAGGC GGCGGCGGGA GCGGCGGTGA TGGACGGGTC 81  CGGGGAGCAG CCCAGAGGCG GGGGGCCCAC CAGCTCTGAG CAGATCATGA AGACAGGGGC CCTTTTGCTT CAGGGTTTCA 161  TCCAGGATCG AGCAGGGCGA ATGGGGGGGG AGGCACCCGA GCTGGCCCTG GACCCGGTGC CTCAGGATGC GTCCACCAAG 241  AAGCTGAGCG AGTGTCTCAA GCGCATCGGG GACGAACTGG ACAGTAACAT GGAGCTGCAG AGGATGATTG CCGCCGTGGA 321  CACAGACTCC CCCCGAGAGG TCTTTTTCCG AGTGGCAGCT GACATGTTTT CTGACGGCAA CTTCAACTGG GGCCGGGTTG 401  TCGCCCTTTT CTACTTTGCC AGCAAACTGG TGCTCAAGGC CCTGTGCACC AAGGTGCCGG AACTGATCAG AACCATCATG 481  GGCTGGACAT TGGACTTCCT CCGGGAGCGG CTGTTGGGCT GGATCCAAGA CCAGGGTGGT TGGGACGGCC TCCTCTCCTA 561  CTTTGGGACG CCCACGTGGC AGACCGTGAC CATCTTTGTG GCGGGAGTGC TCACCGCCTC ACTCACCATC TGGAAGAAGA 641  TGGGCTGAGG CCCCCAGCTG CCTTGGACTG TGTTTTTCCT CCATAAATTA TGGCATTTTT CTGGGAGGGG TGGGGATTGG 721  GGGACGTGGG CATTTTTCTT ACTTTTGTAA TTATTGGGGG GTGTGGGGAA GAGTGGTCTT GAGGGGGTAA TAAACCTCCT 801  TCGGGACACA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 881  AAAAAAAA >gi|163659848|ref|NM_138761.3|BCL2-associated X protein (BAX), transcript variant alpha TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTC CGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCA TCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAG AAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATTGCCGCCGTGGA CACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGGGTTG TCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATG GGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGGACGGCCTCCTCTCCTA CTTTGGGACGCCCACGTGGCAGACCGTGACCATCTTTGTGGCGGGAGTGCTCACCGCCTCACTCACCATCTGGAAGAAGA TGGGCTGAGGCCCCCAGCTGCCTTGGACTGTGTTTTTCCTCCATAAATTATGGCATTTTTCTGGGAGGGGTGGGGATTGG GGGACGTGGGCATTTTTCTTACTTTTGTAATTATTGGGGGGTGTGGGGAAGAGTGGTCTTGAGGGGGTAATAAACCTCCT TCGGGACACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA

	BAX, mRNA isoform beta - Generality top
	Primary source RefSeq : NM_004324.3 (GI:34335114) Name BCL2-associated X protein (BAX), transcript variant beta Type of transcript mRNA Organism Homo sapiens Length 891 nt Map 19q13.3-q13.4 Location Chromosome 19 (NC_000019.9)  strand : + 49458116...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49464066...49464518
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 103 103 1 Exon 2 104 155 52 1 Exon 3 156 302 147 1 Exon 4 303 438 136 1 Exon 6b 439 891 453 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source rs4645885 SNP 174 a/c 1 ? dbSNP rs36017265 SNP 184 c/g 1 ? dbSNP rs4645900 SNP 735 c/t 1 ? dbSNP rs67198826 insertion 106 -/c 1 ? dbSNP rs66527050 insertion 407 -/t 1 ? dbSNP
	CDS top
	Primary source NCBI : CCDS12744 Nucleotide BAX, mRNA isoform beta[NM_004324.3] : 70...726 Length 657 Location Chromosome 19 (NC_000019.9)  strand : + 49458185...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49464066...49464353   Start codon 1 Translation NP_004315.1
	Sequence top
	FASTA 1  TCACGTGACC CGGGCGCGCT GCGGCCGCCC GCGCGGACCC GGCGAGAGGC GGCGGCGGGA GCGGCGGTGA TGGACGGGTC 81  CGGGGAGCAG CCCAGAGGCG GGGGGCCCAC CAGCTCTGAG CAGATCATGA AGACAGGGGC CCTTTTGCTT CAGGGTTTCA 161  TCCAGGATCG AGCAGGGCGA ATGGGGGGGG AGGCACCCGA GCTGGCCCTG GACCCGGTGC CTCAGGATGC GTCCACCAAG 241  AAGCTGAGCG AGTGTCTCAA GCGCATCGGG GACGAACTGG ACAGTAACAT GGAGCTGCAG AGGATGATTG CCGCCGTGGA 321  CACAGACTCC CCCCGAGAGG TCTTTTTCCG AGTGGCAGCT GACATGTTTT CTGACGGCAA CTTCAACTGG GGCCGGGTTG 401  TCGCCCTTTT CTACTTTGCC AGCAAACTGG TGCTCAAGGC CCTGTGCACC AAGGTGCCGG AACTGATCAG AACCATCATG 481  GGCTGGACAT TGGACTTCCT CCGGGAGCGG CTGTTGGGCT GGATCCAAGA CCAGGGTGGT TGGGTGAGAC TCCTCAAGCC 561  TCCTCACCCC CACCACCGCG CCCTCACCAC CGCCCCTGCC CCACCGTCCC TGCCCCCCGC CACTCCTCTG GGACCCTGGG 641  CCTTCTGGAG CAGGTCACAG TGGTGCCCTC TCCCCATCTT CAGATCATCA GATGTGGTCT ATAATGCGTT TTCCTTACGT 721  GTCTGATCAA TCCCCGATTC ATCTACCCTG CTGACCTCCC AGTGACCCCT GACCTCACTG TGACCTTGAC TTGATTAGTG 801  CCTTCTGCCC TCCCTGGAGC CTCCACTGCC TCTGGAATTG CTCAAGTTCA TTGATGACCC TCTGACCCTA GCTCTTTCCT 881  TTTTTTTTTT T >gi|34335114|ref|NM_004324.3|BCL2-associated X protein (BAX), transcript variant beta TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTC CGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCA TCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAG AAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATTGCCGCCGTGGA CACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGGGTTG TCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATG GGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGGTGAGACTCCTCAAGCC TCCTCACCCCCACCACCGCGCCCTCACCACCGCCCCTGCCCCACCGTCCCTGCCCCCCGCCACTCCTCTGGGACCCTGGG CCTTCTGGAGCAGGTCACAGTGGTGCCCTCTCCCCATCTTCAGATCATCAGATGTGGTCTATAATGCGTTTTCCTTACGT GTCTGATCAATCCCCGATTCATCTACCCTGCTGACCTCCCAGTGACCCCTGACCTCACTGTGACCTTGACTTGATTAGTG CCTTCTGCCCTCCCTGGAGCCTCCACTGCCTCTGGAATTGCTCAAGTTCATTGATGACCCTCTGACCCTAGCTCTTTCCT TTTTTTTTTTT

	BAX, mRNA isoform delta - Generality top
	Primary source RefSeq : NM_138763.3 (GI:163659849) Name BCL2-associated X protein (BAX), transcript variant delta Type of transcript mRNA Organism Homo sapiens Length 741 nt Map 19q13.3-q13.4 Location Chromosome 19 (NC_000019.9)  strand : + 49458116...49458218   49458804...49458855   49459454...49459589   49464066...49464170   49464788...49465054
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 103 103 1 Exon 2 104 155 52 1 Exon 4 156 291 136 1 Exon 6c 292 396 105 1 Exon 8a 397 663 267 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS12743 Nucleotide BAX, mRNA isoform delta[NM_138763.3] : 70...501 Length 432 Location Chromosome 19 (NC_000019.9)  strand : + 49458185...49458218   49458804...49458855   49459454...49459589   49464066...49464170   49464788...49464892   Start codon 1 Translation NP_620118.1
	Sequence top
	FASTA 1  TCACGTGACC CGGGCGCGCT GCGGCCGCCC GCGCGGACCC GGCGAGAGGC GGCGGCGGGA GCGGCGGTGA TGGACGGGTC 81  CGGGGAGCAG CCCAGAGGCG GGGGGCCCAC CAGCTCTGAG CAGATCATGA AGACAGGGGC CCTTTTGCTT CAGGGGATGA 161  TTGCCGCCGT GGACACAGAC TCCCCCCGAG AGGTCTTTTT CCGAGTGGCA GCTGACATGT TTTCTGACGG CAACTTCAAC 241  TGGGGCCGGG TTGTCGCCCT TTTCTACTTT GCCAGCAAAC TGGTGCTCAA GGCCCTGTGC ACCAAGGTGC CGGAACTGAT 321  CAGAACCATC ATGGGCTGGA CATTGGACTT CCTCCGGGAG CGGCTGTTGG GCTGGATCCA AGACCAGGGT GGTTGGGACG 401  GCCTCCTCTC CTACTTTGGG ACGCCCACGT GGCAGACCGT GACCATCTTT GTGGCGGGAG TGCTCACCGC CTCACTCACC 481  ATCTGGAAGA AGATGGGCTG AGGCCCCCAG CTGCCTTGGA CTGTGTTTTT CCTCCATAAA TTATGGCATT TTTCTGGGAG 561  GGGTGGGGAT TGGGGGACGT GGGCATTTTT CTTACTTTTG TAATTATTGG GGGGTGTGGG GAAGAGTGGT CTTGAGGGGG 641  TAATAAACCT CCTTCGGGAC ACAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 721  AAAAAAAAAA AAAAAAAAAA A >gi|163659849|ref|NM_138763.3|BCL2-associated X protein (BAX), transcript variant delta TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTC CGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGGATGA TTGCCGCCGTGGACACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAAC TGGGGCCGGGTTGTCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGAT CAGAACCATCATGGGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGGACG GCCTCCTCTCCTACTTTGGGACGCCCACGTGGCAGACCGTGACCATCTTTGTGGCGGGAGTGCTCACCGCCTCACTCACC ATCTGGAAGAAGATGGGCTGAGGCCCCCAGCTGCCTTGGACTGTGTTTTTCCTCCATAAATTATGGCATTTTTCTGGGAG GGGTGGGGATTGGGGGACGTGGGCATTTTTCTTACTTTTGTAATTATTGGGGGGTGTGGGGAAGAGTGGTCTTGAGGGGG TAATAAACCTCCTTCGGGACACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAA

	BAX, mRNA isoform epsilon - Generality top
	Primary source RefSeq : NM_138764.3 (GI:163659851) Name BCL2-associated X protein (BAX), transcript variant epsilon Type of transcript mRNA Organism Homo sapiens Length 986 nt Map 19q13.3-q13.4 Location Chromosome 19 (NC_000019.9)  strand : + 49458116...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49463495...49463592   49464066...49464170   49464788...49465054
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 103 103 1 Exon 2 104 155 52 1 Exon 3 156 302 147 1 Exon 4 303 438 136 1 Exon 7 439 536 98 1 Exon 6c 537 641 105 1 Exon 8a 642 908 267 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS12745 Nucleotide BAX, mRNA isoform epsilon[NM_138764.3] : 70...564 Length 495 Location Chromosome 19 (NC_000019.9)  strand : + 49458185...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49463495...49463592   49464066...49464093   Start codon 1 Translation NP_620119.1
	Sequence top
	FASTA 1  TCACGTGACC CGGGCGCGCT GCGGCCGCCC GCGCGGACCC GGCGAGAGGC GGCGGCGGGA GCGGCGGTGA TGGACGGGTC 81  CGGGGAGCAG CCCAGAGGCG GGGGGCCCAC CAGCTCTGAG CAGATCATGA AGACAGGGGC CCTTTTGCTT CAGGGTTTCA 161  TCCAGGATCG AGCAGGGCGA ATGGGGGGGG AGGCACCCGA GCTGGCCCTG GACCCGGTGC CTCAGGATGC GTCCACCAAG 241  AAGCTGAGCG AGTGTCTCAA GCGCATCGGG GACGAACTGG ACAGTAACAT GGAGCTGCAG AGGATGATTG CCGCCGTGGA 321  CACAGACTCC CCCCGAGAGG TCTTTTTCCG AGTGGCAGCT GACATGTTTT CTGACGGCAA CTTCAACTGG GGCCGGGTTG 401  TCGCCCTTTT CTACTTTGCC AGCAAACTGG TGCTCAAGGC TGGCGTGAAA TGGCGTGATC TGGGCTCACT GCAACCTCTG 481  CCTCCTGGGT TCAAGCGATT CACCTGCCTC AGCATCCCAA GGAGCTGGGA TTACAGGCCC TGTGCACCAA GGTGCCGGAA 561  CTGATCAGAA CCATCATGGG CTGGACATTG GACTTCCTCC GGGAGCGGCT GTTGGGCTGG ATCCAAGACC AGGGTGGTTG 641  GGACGGCCTC CTCTCCTACT TTGGGACGCC CACGTGGCAG ACCGTGACCA TCTTTGTGGC GGGAGTGCTC ACCGCCTCAC 721  TCACCATCTG GAAGAAGATG GGCTGAGGCC CCCAGCTGCC TTGGACTGTG TTTTTCCTCC ATAAATTATG GCATTTTTCT 801  GGGAGGGGTG GGGATTGGGG GACGTGGGCA TTTTTCTTAC TTTTGTAATT ATTGGGGGGT GTGGGGAAGA GTGGTCTTGA 881  GGGGGTAATA AACCTCCTTC GGGACACAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 961  AAAAAAAAAA AAAAAAAAAA AAAAAA >gi|163659851|ref|NM_138764.3|BCL2-associated X protein (BAX), transcript variant epsilon TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTC CGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCA TCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAG AAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATTGCCGCCGTGGA CACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGGGTTG TCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCTGGCGTGAAATGGCGTGATCTGGGCTCACTGCAACCTCTG CCTCCTGGGTTCAAGCGATTCACCTGCCTCAGCATCCCAAGGAGCTGGGATTACAGGCCCTGTGCACCAAGGTGCCGGAA CTGATCAGAACCATCATGGGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTG GGACGGCCTCCTCTCCTACTTTGGGACGCCCACGTGGCAGACCGTGACCATCTTTGTGGCGGGAGTGCTCACCGCCTCAC TCACCATCTGGAAGAAGATGGGCTGAGGCCCCCAGCTGCCTTGGACTGTGTTTTTCCTCCATAAATTATGGCATTTTTCT GGGAGGGGTGGGGATTGGGGGACGTGGGCATTTTTCTTACTTTTGTAATTATTGGGGGGTGTGGGGAAGAGTGGTCTTGA GGGGGTAATAAACCTCCTTCGGGACACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAA

	BAX, mRNA isoform sigma - Generality top
	Primary source RefSeq : NM_138765.3 (GI:163659850) Name BCL2-associated X protein (BAX), transcript variant sigma Type of transcript mRNA Organism Homo sapiens Length 849 nt Map 19q13.3-q13.4 Location Chromosome 19 (NC_000019.9)  strand : + 49458116...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49464066...49464170   49464827...49465054
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 103 103 1 Exon 2 104 155 52 1 Exon 3 156 302 147 1 Exon 4 303 438 136 1 Exon 6c 439 543 105 1 Exon 8b 544 771 228 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI :  Nucleotide BAX, mRNA isoform sigma[NM_138765.3] : 70...609 Length 540 Location Chromosome 19 (NC_000019.9)  strand : + 49458185...49458218   49458804...49458855   49458943...49459089   49459454...49459589   49464066...49464170   49464827...49464892   Start codon 1 Translation NP_620120.1
	Sequence top
	FASTA 1  TCACGTGACC CGGGCGCGCT GCGGCCGCCC GCGCGGACCC GGCGAGAGGC GGCGGCGGGA GCGGCGGTGA TGGACGGGTC 81  CGGGGAGCAG CCCAGAGGCG GGGGGCCCAC CAGCTCTGAG CAGATCATGA AGACAGGGGC CCTTTTGCTT CAGGGTTTCA 161  TCCAGGATCG AGCAGGGCGA ATGGGGGGGG AGGCACCCGA GCTGGCCCTG GACCCGGTGC CTCAGGATGC GTCCACCAAG 241  AAGCTGAGCG AGTGTCTCAA GCGCATCGGG GACGAACTGG ACAGTAACAT GGAGCTGCAG AGGATGATTG CCGCCGTGGA 321  CACAGACTCC CCCCGAGAGG TCTTTTTCCG AGTGGCAGCT GACATGTTTT CTGACGGCAA CTTCAACTGG GGCCGGGTTG 401  TCGCCCTTTT CTACTTTGCC AGCAAACTGG TGCTCAAGGC CCTGTGCACC AAGGTGCCGG AACTGATCAG AACCATCATG 481  GGCTGGACAT TGGACTTCCT CCGGGAGCGG CTGTTGGGCT GGATCCAAGA CCAGGGTGGT TGGACCGTGA CCATCTTTGT 561  GGCGGGAGTG CTCACCGCCT CACTCACCAT CTGGAAGAAG ATGGGCTGAG GCCCCCAGCT GCCTTGGACT GTGTTTTTCC 641  TCCATAAATT ATGGCATTTT TCTGGGAGGG GTGGGGATTG GGGGACGTGG GCATTTTTCT TACTTTTGTA ATTATTGGGG 721  GGTGTGGGGA AGAGTGGTCT TGAGGGGGTA ATAAACCTCC TTCGGGACAC AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 801  AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAA >gi|163659850|ref|NM_138765.3|BCL2-associated X protein (BAX), transcript variant sigma TCACGTGACCCGGGCGCGCTGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGGCGGTGATGGACGGGTC CGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATGAAGACAGGGGCCCTTTTGCTTCAGGGTTTCA TCCAGGATCGAGCAGGGCGAATGGGGGGGGAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAG AAGCTGAGCGAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATTGCCGCCGTGGA CACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTTTCTGACGGCAACTTCAACTGGGGCCGGGTTG TCGCCCTTTTCTACTTTGCCAGCAAACTGGTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATG GGCTGGACATTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGACCGTGACCATCTTTGT GGCGGGAGTGCTCACCGCCTCACTCACCATCTGGAAGAAGATGGGCTGAGGCCCCCAGCTGCCTTGGACTGTGTTTTTCC TCCATAAATTATGGCATTTTTCTGGGAGGGGTGGGGATTGGGGGACGTGGGCATTTTTCTTACTTTTGTAATTATTGGGG GGTGTGGGGAAGAGTGGTCTTGAGGGGGTAATAAACCTCCTTCGGGACACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

	Q07812 - Generality top
	Primary source Uniprot : Q07812 Name Apoptosis regulator BAX Alternative name(s) Bcl-2-like protein 4 Synonym(s) Bcl2-L-4 Organism Homo sapiens Length 192 aa Protein existence ---
	External Links top
	ArrayExpress Q07812   Prints PR01862   Smart SM00337   Refseq NP_620119.2   NP_620118.1   NP_620116.1   NP_004315.1   Uniprot Q07812   EBI EBI-516580   InterPro IPR020728   IPR020726   IPR020717   IPR000712   IPR002475   KEGG hsa:581   PDB 2K7W   2G5B   1F16   PDBsum 2K7W   2G5B   1F16   PROSITE PS01259   PS01258   PS01080   PS50062   Pfam PF00452
	General annotation (Comments) top
	Domain Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity). Function Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis. Similarity Belongs to the Bcl-2 family. Subcellular location Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14- 3-3 proteins in the cytoplasm. Under stress conditions, redistributes to the mitochondrion membrane through the release from JNK-phosphorylated 14-3-3 proteins. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential). Subunit Homodimer. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Tissue specificity Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
	Ontologies top
	Biological process B cell apoptosis [GO:0001783] release of cytochrome c from mitochondria [GO:0001836] DNA fragmentation involved in apoptotic nuclear change [GO:0006309] cleavage of lamin [GO:0006922] transformed cell apoptosis [GO:0006927] mitochondrial fusion [GO:0008053] induction of apoptosis by extracellular signals [GO:0008624] induction of apoptosis by intracellular signals [GO:0008629] negative regulation of survival gene product expression [GO:0008634] activation of caspase activity by cytochrome c [GO:0008635] response to toxin [GO:0009636] establishment or maintenance of transmembrane electrochemical gradient [GO:0010248] nuclear fragmentation involved in apoptotic nuclear change [GO:0030264] release of matrix enzymes from mitochondria [GO:0032976] regulation of protein homodimerization activity [GO:0043496] regulation of protein heterodimerization activity [GO:0043497] positive regulation of neuron apoptosis [GO:0043525] mitochondrial fragmentation involved in apoptosis [GO:0043653] induction of retinal programmed cell death [GO:0046674] protein homooligomerization [GO:0051260] regulation of mitochondrial membrane potential [GO:0051881] Cellular component mitochondrial outer membrane [GO:0005741] mitochondrial permeability transition pore complex [GO:0005757] endoplasmic reticulum membrane [GO:0005789] cytosol [GO:0005829] Molecular function lipid binding [GO:0008289] protein homodimerization activity [GO:0042803] protein heterodimerization activity [GO:0046982] BH3 domain binding [GO:0051434]
	Binary interactions top
	With Uniprot accession IntAct ??? P70444 EBI-516580,EBI-783400 BAK Q16611 EBI-516580,EBI-519866 B2CL1 Q07817 EBI-516580,EBI-78035 BAX Q07812 EBI-516580,EBI-516580 PRKCE Q02156 EBI-516580, Bcl-X(L) Q07817-1 EBI-516580,EBI-287195 tom-40 (xeno) P24391 EBI-516580,EBI-1791540 BCL2 P10415 EBI-516580,EBI-77694
	Alternative product(s) top
	Uniprot Identifier Difference(s) with the 'canonical' sequence Notes Sequences Isoform Alpha Q07812-1 --- 'Canonical' sequence Get Fasta Isoform Beta Q07812-2, Q07814-1 159-192  :  DGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG -> VRL LKPPHPHHRALTTAPAPPSLPPATPLGPWAFWSRSQWCPLP IFRSSDVVYNAFSLRV --- Get Fasta Isoform Gamma Q07812-3, Q07815-1 12-41  :  GPTSSEQIMKTGALLLQGFIQDRAGRMGGE -> VSSRIEQ GEWGGRHPSWPWTRCLRMRPPRS 42-192  :  Missing --- Get Fasta Isoform Delta Q07812-4, P55269-1 30-78  :  Missing --- Get Fasta Isoform Epsilon Q07812-5 125-192  :  LCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYF GTPTWQTVTIFVAGVLTASLTIWKKMG -> GVKWRDLGSL QPLPPGFKRFTCLSIPRSWDYRPCAPRCRN --- Get Fasta Isoform Zeta Q07812-6 1-78  :  Missing --- Get Fasta Isoform Psi Q07812-7 1-19  :  Missing --- Get Fasta Isoform Sigma Q07812-8 159-171  :  Missing --- Get Fasta
	Sequence annotation top
	Feature key Position Length Description Feature identifier Region           Motif 59 - 73 15 BH3 Q07812-MOTIF-59 Motif 98 - 118 21 BH1 Q07812-MOTIF-98 Motif 150 - 165 16 BH2 Q07812-MOTIF-150 Transmembrane 172 - 192 21 Helical; (Potential) Q07812-TRANSMEM-172 Natural variations           Natural variant site 11 - 11 1 G -> E (in a plasmacytoma cell line) VAR_013575 Natural variant site 39 - 39 1 G -> R (in dbSNP:rs36017265) VAR_047053 Natural variant site 67 - 67 1 G -> R (in a T-cell acute lymphoblastic leukemia cell line; loss of heterodimerization with Bcl-2 or Bcl- X(L)) VAR_007809 Natural variant site 108 - 108 1 G -> V (in a Burkitt lymphoma; loss of homodimerization) VAR_013576 Alternative sequence 1 - 19 19 Missing VSP_031238 Alternative sequence 1 - 78 78 Missing VSP_031239 Alternative sequence 12 - 41 30 GPTSSEQIMKTGALLLQGFIQDRAGRMGGE -> VSSRIEQ GEWGGRHPSWPWTRCLRMRPPRS VSP_031234 Alternative sequence 30 - 78 49 Missing VSP_031235 Alternative sequence 42 - 192 151 Missing VSP_031236 Alternative sequence 125 - 192 68 LCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYF GTPTWQTVTIFVAGVLTASLTIWKKMG -> GVKWRDLGSL QPLPPGFKRFTCLSIPRSWDYRPCAPRCRN VSP_031240 Alternative sequence 159 - 192 34 DGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG -> VRL LKPPHPHHRALTTAPAPPSLPPATPLGPWAFWSRSQWCPLP IFRSSDVVYNAFSLRV VSP_031237 Alternative sequence 159 - 171 13 Missing VSP_037475 Amino acid modifications           Modified residue 1 - 1 1 N-acetylmethionine Q07812-MOD_RES-1 Experimental info           Mutagenesis 184 - 184 1 S->V: Constitutive mitochondrial location Q07812-MUTAGEN-184
	Sequence top
	FASTA 1  MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI 81  AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG 161  LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG >sp|Q07812|BAX_human Apoptosis regulator BAX MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMI AAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDG LLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG