(RELA) v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  6257
 Official symbol  RELA
 Official name  v-rel reticuloendotheliosis viral oncogene homolog A (avian)
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 11 (NC_000011.9) :  65421066...65430442  (-)
 Map  11q13
 Length  9377  nt
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Alternative name(s) and Synynom(s) top
Synonyms MGC131774; p65; NFKB3
Alternative name(s) v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65; v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)); nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
External Links top
Ensembl ENSG00000173039
Entrez 5970
HGNC 9955
HPRD 01241
Comment top
Summary NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM].
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Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
1  GCGCGCAGGC GCGGCCGGAT TCCGGGCAGT GACGCGACGG CGGGCCGCGC GGCGCATTTC CGCCTCTGGC GAATGGCTCG
81  TCTGTAGTGC ACGCCGCGGG CCCAGCTGCG ACCCCGGCCC CGCCCCCGGG ACCCCGGCCA TGGACGGTGA GGTCGCCCTC
161  TGACCCCGCG GGGTGGCATC GCCGGGGCCG CCGCGGCTGT GGCGGGAGCC CCCGCGCCGC TTTCCGCCCC TTCCTGCGCC
241  GACGGGCGCT GCGCAGGGAG CGGTCGGCCT GCCGGATGGT GGCGCGGGGC GGGGCAGGCG GGGAGGGGTC TGACTCAGTT
321  TCCCCTCTGG GTGGAGGGGG TGGCCCTTGA CTCAGCATCC TCCCTGGGTG GGGGAGCAGA GGGAACCTTG ACTCAGTTTC
401  CCTCCACACC GTCCATGGGG GCAGCTCTGG CTTCGTTTCC CTATTAGGGG AGAACGCATC TGATTCAGTT TCCTCTCTGG
481  AGGGAGGTGG GGCGTGCCCT CCCTCAATTT TCCTTAAGAA AGTACAACAG GCCCTGATTC AGCTTCCCTC TGGAGAAGAA
561  GGATTCCTTA CCCCGTTTTC CCTCAAGAAG CAGGTGTTTC TGGTTCCTTT CCTCCACCCC TTAGTTTCAC CGCAGGTTCT
641  AGGGAGCAGG TCCTGACTCA GTTCCCCTGG GAGGGAGCCT GGCTTCTCCT CTCCGTGGAG AGCAGATTCC TCCTTGTGAG
721  AATGGGCATT GGGTGTGTGC TGACCCTGAT CTCCCTCCCC TTTCAGAACT GTTCCCCCTC ATCTTCCCGG CAGGTAAGTG
801  GCCCCCGCGG CGGTCGGGGA GGTGCTCCCT GGGGTAGGGC AGTGGGGGCA GCCGCCTAAT GGGGCTGCGG TGTCCCCTGG
881  CAGAGCCAGC CCAGGCCTCT GGCCCCTATG TGGAGATCAT TGAGCAGCCC AAGCAGCGGG GCATGCGCTT CCGCTACAAG
961  TGCGAGGGGC GCTCCGCGGG CAGCATCCCA GGCGAGAGGA GCACAGATAC CACCAAGACC CACCCCACCA TCAAGGTCAG
1041  CACTGCGCCA GGGTGTGCGG GGAAGGGACT GTGGAACCCC AGCCCTCTGT GTTTGGGAGT CAGGTTTGGA TGTCTGGGCC
1121  TCTGTACTTT GGACAGATCA ATGGCTACAC AGGACCAGGG ACAGTGCGCA TCTCCCTGGT CACCAAGGAC CCTCCTCACC
1201  GGCCTCACCC CCACGAGCTT GTAGGAAAGG ACTGCCGGGA TGGCTTCTAT GAGGCTGAGC TCTGCCCGGA CCGCTGCATC
1281  CACAGGTGAG GTCCCTGCAG GCTAGGAGGC CCAGCATGAG GGGACAGGAG GCGGGCTATG AAGTAGCCGC TACAGTGTTA
1361  CTCCTTTCTG GACCCAGGGC AGAATTCCTC ACTCCTTGCC CTGACTCAGC TCTGCAAGTA AACTGCCTTT GTCTTGAAAT
1441  TATCTATTTG TACGTTTACT CTAGCAGATG AGTTCCAGGG GATACGGATG GGTCCCTAAT CACTTCTGAA TTCCTGACCC
1521  CTGTAGCTGG AAGGACAAGT CCCTCAGAGT CACGTCTCTT GTTTGAGGAA GAAAACCATT GAACCAGCAC TCTCCCCTGG
1601  AGTTGACATT GCAGTTGACA GAGACAGGCT GTAAAAAAAT ATACAGGCCG GGCATAGTGG CTCATGCTTA TAATCCTAGC
1681  ACTTCGGGAG GCCAAGGCAG GAAGATCTCT TGAGCCTAGG AATTCAAGAC TAGCCAAGGC AACATAGTGA GACCCCATGT
1761  CTACAAAAAA TAAGAAATTA GCTGGGTATG GTGGCATGCG CCTATAGTCC CAGGGAGGCT GAGGTGGGAG GATCGCCTGA
1841  GCCCAGGAGG TCACTGCTGC GGCAAGCTAT GATTGCACCA CTGCACTTGG GTGGCAGGGC GATACCTTGT CTTTTTTTTT
1921  TTTTTTTTTT TTTTAAGAAA GAGTCTTGCT CTGTCCCCAG ACTGGAGTGC AGTGGCGCGA TCTCAGCTCA CTGCAACCTC
2001  CACCTTCCGG GTTCATGCCA TTCTCCTGCC TCAGCTTCCC GAATAGCTGG GACTACAGGT GCCTGCCACC ACGCCTGGCT
2081  AATTTTTTGT ATTTTTTAGT AGAGACAGGG TTTCACCGTG TTAGCCAGGA TGGTCTCAAT CTCCTGACCT TGTGATCTGC
2161  CTGTCTTGGC CTCCCAAAGT GCTGGGATTA CAGGCTTGAG CCACCGCACC CGGCCCGACA CTGTGTCTCT TAAAAATAAA
2241  TAAATACACA GATAAATAAA CAAGGTGCTG TCAGAGTAAC AGTTTCAGTC CTGAAAATAA AACGAGGTCA TAGGATAGAA
2321  GGATAACCTG GGGTGGGGGA GTTAGGGGAG CTGGTGTGTG ATGACTTTAG ATTGGGAGGT CAGGGAAGGC CTCCCTCAGC
2401  TAAGACTTGA ATGGTGAGAA GGAGGAGAGA AGTAGGAAAA GAACATTCCA AGCCGACCAA ACAAGTGCAA AGGCCTTGAG
2481  GTGGGAATGA GTGTCCTGTG TTTAGAGAGT GGAAAAGGAG CCCCGGTGGC TGTAAGCAGG GAGCCCACAG GGAGGCTGGC
2561  AGGGGCAGGG GCACGGAGGT GCTTGTCAGC TGAGTGAAGG GACAGGGTTC GTTGCAGCAC AGTAGGAAGC CACTGGAGAG
2641  GGTTAGGCAT GGAGCGATGA TCTAGGGGTG GGCAGAGTAG GAAGGAGCAG GCTGGGCAAG GCAGGAAGGT CTGGGCTCTG
2721  TGAGAGACAG TGGGACAGAC GACTGGGGGC GCTCAGTTTC CAGAACCTGG GAATCCAGTG TGTGAAGAAG CGGGACCTGG
2801  AGCAGGCTAT CAGTCAGCGC ATCCAGACCA ACAACAACCC CTTCCAAGGT GAGGGCAAAC CTGCCTGCCA CACCCGCACC
2881  CTCTGTCACC CTCCCCAGCC CGCCTTTCCT GCATCTCCCT CACTGGCCAA GACACAGTAA AGCTGGAATC TTGGTGCCCA
2961  TTCAGTACTC TCCCACTTTA CCACTGGGAA ACTGAGTCCC AGGAGGGGAC ATGACATTCA GGCCACAGTG GAGTCAGTGC
3041  TGGGTTCTGC CTCCTCTAGG ACTTGTGTTT CACACACGCA CCAGCGGCCC TCCCAGCGCA GAGCTCCCTG CCCCCACTGA
3121  TAGCACCTAT ATCCCCACTT CCCCTGCTCT CCTGATCGCC TGTTTTCTTG GCAGTTCCTA TAGAAGAGCA GCGTGGGGAC
3201  TACGACCTGA ATGCTGTGCG GCTCTGCTTC CAGGTGACAG TGCGGGACCC ATCAGGCAGG CCCCTCCGCC TGCCGCCTGT
3281  CCTTTCTCAT CCCATCTTTG ACAATCGTGA GTAGCGAGGG AGACGCAGGA AGGGGAGAGG GTGGGCCTGA ATAGGAGGAA
3361  GGGGGTTGGG GTGAGTGTGG CCTGCAAGAG GCGCTCTGGC TTCATTCAAT CATCTTGCGT ATTTGTCTAC TCTTCTCTGC
3441  CCAGCTCTTT GTTGGCTGGG GAGAGAGGGC AAAGAAGACC CAGAGCTGTC CTTGAGGTGT AGCTCTGGCC TGGCAGGAAG
3521  TCTAGCAGAG AGTCTGATGG GAGATGGGCA TTTTCAGTAT TGTGTGATGA GAAGGTGGTG TGCCCACAAC TGCGATAATG
3601  ACTCTAGGAA ATGAACTCCC AGGAACAAGA TAGTGTTCGA GAATGATGAT TCAGTGATGG AAGCCCACAG ATGAATTGGG
3681  CTGACTGATC AGCTGCAGTC TTTAGTTAAG TAACCAGCAG GATGAATGGA AATAAAACGA ATCTGGAGCC CCAAGGATGG
3761  GAAACCAGGA TAAACTGGGG GTCAGGAGGG AAGGGCTCAT TGCCAAGGTG GGTATGGACT GGCCTTAAAG ATTGCTTTGG
3841  TCAGGTGGAG AAAGAGTGTG ATCAGATTGG CACCCACTGG ACTATAAGCT CCGGGAGAGC AGAGAGGTTT GGGTTTTGTG
3921  TGTGGTCGTA TTCTTGCTTA GATCAGTGTT GAGTGCACAG TAGGCAAATA CTTGTTGAAT CGGTTGGGGT GAGGAGCTAA
4001  TAAGAAGGTC TGACTTTGGC TACAAAGGTG TAGGTGGCAA GCTCTGGGCA ACCTTGACTC TGGGCTGGGC AGGGAAGTTG
4081  CATCTCCTGC AGGCCACCCT GGGGACCTCT CGTGGCTCAG GTCATCCTCC CTTGTTTTCA CTGCCTCAGG TGCCCCCAAC
4161  ACTGCCGAGC TCAAGATCTG CCGAGTGAAC CGAAACTCTG GCAGCTGCCT CGGTGGGGAT GAGATCTTCC TACTGTGTGA
4241  CAAGGTGCAG AAAGGTATAC ATCAGGAGGC AGGGGTGGGC TCTTGGGAGC AAGGGGTGAA GCTGAGCAGA GAAGTGGAGT
4321  GTCAGGTAAC TGGCTTTGGA TACTTCCTCC TGTGCCTCGG GGGCCTCAGG TGGGCCGAAG GGTGATGTAT CAGAAGACAA
4401  GCATCAGAAG TTGAGGGGGA GACCATGGAG GGTTAGACAC ACTGACCCAC ACTGCCACCG CATCTCCTGC AGAGGACATT
4481  GAGGTGTATT TCACGGGACC AGGCTGGGAG GCCCGAGGCT CCTTTTCGCA AGCTGATGTG CACCGACAAG TGGCCATTGT
4561  GTTCCGGACC CCTCCCTACG CAGACCCCAG CCTGCAGGCT CCTGTGCGTG TCTCCATGCA GCTGCGGCGG CCTTCCGACC
4641  GGGAGCTCAG TGAGCCCATG GAATTCCAGT ACCTGCCAGA TACAGGTACA CAGCTGGGGT GGCAGCATCA GGGCAGCTGG
4721  GCTCTGTGCC GTGAGAGAGA GGCCAAGACT GCATGTCTGG GGCTGTGGTT GAGGGCCAGA AGCTGGAGTC AGAGCTTGGG
4801  ATCCAAGAAA CTGGAATCCA TTTCTTGCCT CATTTAATAA TAATGATACC TCAGACATTG AGCTAGTACT ACACATCTGC
4881  CCCTATTCCA GGCACTTCAC TGGATTACCT GATTTTAATC TCATGACCCT TTTGAAGTAG GAGATAGTGT CCAACTTGCC
4961  TGGGTTCACG TGGCTAGTAA GTAGCAGAGT CTAGCAGAGT CAGCGTTGGA ACCCAGGCCA TCTGGCTTCA GGATCCTTTT
5041  GCCACACTGG TTGTCTTGTC ACTACCATAC AGCCCAGCCA CATTTTGGTC GAGGTTTGAG TGTCCACTTG GTACCAGGGC
5121  CTGTGCCAGG TATTGTGAAT ACAAAAAATG AGTAAGACAT GCTCCCTGCC CTTCAGAGTC TCAGTCACTT GAGGAAGACA
5201  AATGTGCAAA ACAGATCCTT AAGTCACGGA ATGACATGTG AAATGGAGGT GTGCGCAGAG AAGCACGGGG GCACAGTGGC
5281  CTCCGGGGAG CTGGAGACAG CTGCATGGAG AAGGTGGCAT TGAAGCTGGA GAAAGACACA GAAGTGTGTT CTCCAGGCAG
5361  GTGGCCCAGC ACCTGGAAGG GAAGGGGTGT TGGCAACTGC ACGGCCTATT CAGGGCCACC TTCGTGGTTT GAGCTGATGT
5441  TGGGCAGTGA GCAGGCTCAG AGATTGGAGG GCCTGGTTAA GCTGAAGGCC TCTAAGCAGA GAGGTGACAG GAGCAGATTT
5521  GGAAGTTGAC TCAGGAGGCC ACGTGTAGAA GATCAGAGAC AGACAGACTC AAAGCAGGGA GGCCATTCTG GAAATGTTGC
5601  TGTAGTCCAG GAAGAGAAGA TGCGGCACAA ACCTTACAGA AGGAATAGCA GAGCAAGATC ACATCTCCAC CACTGTCCTC
5681  AGTTACCCTT CAGCCCTGCA GCCGTTTTGC GTCTTACAGA CCAAGCTCAG TCTCACCTCA GGACCTGTGT CTAGCTGTTG
5761  CCTCTGCTTG GAATGCCCAA GGTTTTAATG CAAGTGGCTC ATGCCAGTCC TTCCCTGACC TCTAAATTAG CCCTTCCCTC
5841  TACATTTAGA CTGTCCTGAC CTCACTTCCA GTATTGTTAC ATCACCATAT CGTCCCTGGA CCACCGTCAC TTGAGATTTT
5921  CTGGTTTGGT TTTGTTTGTT TGTTTGAGAC AGAGTCTCAC TCTTGTCGCC CAGGCTGGAG TGCAGTGGTG CAATCTCGGC
6001  TCACTGCAAC CTCCACCTCC CGGGTTCAAG TGATTCTCCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC
6081  CACCACATCC GGCTAATTTT TTGTATTTTT AGTAGAGACG GGGTTTTCAC CATGTTGGCC AGGGTGGTCT CGATCTCTTG
6161  ACCTCGTGAT CCACCCGCCT CGACCTCCCA AAGTGCTGGG ATTACAGGCG TGAGCCACCA CGCCTGGCCG AGATTTTCTG
6241  GTTTGTATAT ATGATTGTGT CCCTCTCACT TTTTCACTAG GATGCCAACT TTTTGGGAGC AGACACCTTG TGTGCATACT
6321  CACGGCCACA TCCCCAGTGT CTAGAAGGGA GGCTGGCACA TAGTAGGTGC TTGATAAATA TATGTCAAGT TACTGGCGGG
6401  GAGTGAGAGA AAAGAAGATA ATCATTCCAA GGTTTCTAGC TTTGGTGACA GGGCAGATGG CGGATGGTCA GGGAATGCAG
6481  GAGAAAGAAC CTAGTTTTTG AGGGATGATG AGGTTGTCTT TGAATTGATG GAATTGAAGT GCTTTGGAGC TACTGAAATA
6561  CCACTGTAAT TAGAAAGACA GTTCTGAAAG CTCTGACTAA AATATGAAAC CATTAGAGAT AAGAATAAGA GTCTCTGCTG
6641  AAGTCTTAAG GCAGTTGTGC CTCAGCTGCC CCAGAGTGCC AAGAAATTCT CGCCAGGCCT GGGTGGAGGC TGACAATGAG
6721  CCAGGATGTG AGCAGTGCAG GAAGGTGTGA GCTGGAGGCT GGGGCCCCCC AGGTCTCCTC TTTGCCCAGA GCATGGCCCC
6801  TGTACTCGGC CTCACCATGT GGTCTTAGAG GGGCAGATTC AGCCAACAGA GGCCTCCAAA AGCTGTGGGA TTCTCAGAAC
6881  TGCTGAGTGT CACACATCCC TTCTCATTGG CAGAGAAGGT TGGGAGAATG GGTCTTGGGA AAGCCTGGCT CCTCCCCTTC
6961  CTCCTGAGGG ACCTTTGAGA GCGTCGGGGA CCCACCTGAG GAGAGCAAGT CCCACTTCTC CCCCTTACTT TCCCAGACGA
7041  TCGTCACCGG ATTGAGGAGA AACGTAAAAG GACATATGAG ACCTTCAAGA GCATCATGAA GAAGAGTCCT TTCAGCGGTG
7121  AGATGGGGAC TGGGAAAGCC AGAGAGGAAG GCAGCGGGCA GGGAGGGGAC ACCCTGGGGC TGAGAACTGA CCTAGCCCTT
7201  GCCCTACAGG ACCCACCGAC CCCCGGCCTC CACCTCGACG CATTGCTGTG CCTTCCCGCA GCTCAGCTTC TGTCCCCAAG
7281  CCAGGTAAGG ATTTCCTTTT GTCCCACTGG AACGACAGGT TCAGCTCTGT TCAGCTGAGG AGCAGTGGAG ATGAAGACTC
7361  CTGGGCCCCA TTACAGACCT ACTGAATCAG AGGCTTTGAA AGGATGGCGC AGGAACCAGC GACTTCCTGG GATGCTAATG
7441  CACACTGAAG CCTGGGAACC ACCGTGCCAC TTAAATTCTA TATTGGGTAT CTTGGGAATC AGAAGTTAAA AATGCAGAAT
7521  CTCTGCTCTC ATCTCTCACT TGAATTGGGG GAACAAAAAT CACCTCTAAA TTAGCAAGAT GTGTGTGCCT GTGCGAGGCT
7601  CAAAAACTGA CAAGCTCTGC ACTTCAGGCC GCTGCTCACT TGGTGCTCCA TGGGCTCATT GCCTCTCAGG ACTTAGTTTT
7681  TCAGCTGTAA ACTGAGGAGT CCAGCTTATC TCTCCAAGTG TCCCTTCCTC TAAAAGGCTG GAAGAGTTTC GTGGGCTTGA
7761  GTAGTCAGGG AGGACTCCAA GGTGGAGGTG TGGCTAGAAC TGGACCCTAC AGGCTGGGTC AGATGGGGTA AGAGGAAGGA
7841  GATAGGGTGT TGGCAGTGAC TCCCTAGAGA GGGATTGAGC CTGAGCACCA TGAAGAGGGG CTGGGGTACA GAGGACGGGG
7921  TGGATCTCTA GGGCTTTCTC TGACCCCTGC CTCTCTGTCT CTCTCCTCCA GCACCCCAGC CCTATCCCTT TACGTCATCC
8001  CTGAGCACCA TCAACTATGA TGAGTTTCCC ACCATGGTGT TTCCTTCTGG GCAGATCAGC CAGGCCTCGG CCTTGGCCCC
8081  GGCCCCTCCC CAAGTCCTGC CCCAGGCTCC AGCCCCTGCC CCTGCTCCAG CCATGGTATC AGCTCTGGCC CAGGCCCCAG
8161  CCCCTGTCCC AGTCCTAGCC CCAGGCCCTC CTCAGGCTGT GGCCCCACCT GCCCCCAAGC CCACCCAGGC TGGGGAAGGA
8241  ACGCTGTCAG AGGCCCTGCT GCAGCTGCAG TTTGATGATG AAGACCTGGG GGCCTTGCTT GGCAACAGCA CAGACCCAGC
8321  TGTGTTCACA GACCTGGCAT CCGTCGACAA CTCCGAGTTT CAGCAGCTGC TGAACCAGGG CATACCTGTG GCCCCCCACA
8401  CAACTGAGCC CATGCTGATG GAGTACCCTG AGGCTATAAC TCGCCTAGTG ACAGGGGCCC AGAGGCCCCC CGACCCAGCT
8481  CCTGCTCCAC TGGGGGCCCC GGGGCTCCCC AATGGCCTCC TTTCAGGAGA TGAAGACTTC TCCTCCATTG CGGACATGGA
8561  CTTCTCAGCC CTGCTGAGTC AGATCAGCTC CTAAGGGGGT GACGCCTGCC CTCCCCAGAG CACTGGGTTG CAGGGGATTG
8641  AAGCCCTCCA AAAGCACTTA CGGATTCTGG TGGGGTGTGT TCCAACTGCC CCCAACTTTG TGGATGTCTT CCTTGGAGGG
8721  GGGAGCCATA TTTTATTCTT TTATTGTCAG TATCTGTATC TCTCTCTCTT TTTGGAGGTG CTTAAGCAGA AGCATTAACT
8801  TCTCTGGAAA GGGGGGAGCT GGGGAAACTC AAACTTTTCC CCTGTCCTGA TGGTCAGCTC CCTTCTCTGT AGGGAACTCT
8881  GGGGTCCCCC ATCCCCATCC TCCAGCTTCT GGTACTCTCC TAGAGACAGA AGCAGGCTGG AGGTAAGGCC TTTGAGCCCA
8961  CAAAGCCTTA TCAAGTGTCT TCCATCATGG ATTCATTACA GCTTAATCAA AATAACGCCC CAGATACCAG CCCCTGTATG
9041  GCACTGGCAT TGTCCCTGTG CCTAACACCA GCGTTTGAGG GGCTGGCCTT CCTGCCCTAC AGAGGTCTCT GCCGGCTCTT
9121  TCCTTGCTCA ACCATGGCTG AAGGAAACCA GTGCAACAGC ACTGGCTCTC TCCAGGATCC AGAAGGGGTT TGGTCTGGGA
9201  CTTCCTTGCT CTCCCTCTTC TCAAGTGCCT TAATAGTAGG GTAAGTTGTT AAGAGTGGGG GAGAGCAGGC TGGCAGCTCT
9281  CCAGTCAGGA GGCATAGTTT TTACTGAACA ATCAAAGCAC TTGGACTCTT GCTCTTTCTA CTCTGAACTA ATAAATCTGT
9361  TGCCAAGCTG GCTAGAG
>ref|Gene_ID:5970|RELA|NC_000011.9:65421066...65430442 (-)
GCGCGCAGGCGCGGCCGGATTCCGGGCAGTGACGCGACGGCGGGCCGCGCGGCGCATTTCCGCCTCTGGCGAATGGCTCG
TCTGTAGTGCACGCCGCGGGCCCAGCTGCGACCCCGGCCCCGCCCCCGGGACCCCGGCCATGGACGGTGAGGTCGCCCTC
TGACCCCGCGGGGTGGCATCGCCGGGGCCGCCGCGGCTGTGGCGGGAGCCCCCGCGCCGCTTTCCGCCCCTTCCTGCGCC
GACGGGCGCTGCGCAGGGAGCGGTCGGCCTGCCGGATGGTGGCGCGGGGCGGGGCAGGCGGGGAGGGGTCTGACTCAGTT
TCCCCTCTGGGTGGAGGGGGTGGCCCTTGACTCAGCATCCTCCCTGGGTGGGGGAGCAGAGGGAACCTTGACTCAGTTTC
CCTCCACACCGTCCATGGGGGCAGCTCTGGCTTCGTTTCCCTATTAGGGGAGAACGCATCTGATTCAGTTTCCTCTCTGG
AGGGAGGTGGGGCGTGCCCTCCCTCAATTTTCCTTAAGAAAGTACAACAGGCCCTGATTCAGCTTCCCTCTGGAGAAGAA
GGATTCCTTACCCCGTTTTCCCTCAAGAAGCAGGTGTTTCTGGTTCCTTTCCTCCACCCCTTAGTTTCACCGCAGGTTCT
AGGGAGCAGGTCCTGACTCAGTTCCCCTGGGAGGGAGCCTGGCTTCTCCTCTCCGTGGAGAGCAGATTCCTCCTTGTGAG
AATGGGCATTGGGTGTGTGCTGACCCTGATCTCCCTCCCCTTTCAGAACTGTTCCCCCTCATCTTCCCGGCAGGTAAGTG
GCCCCCGCGGCGGTCGGGGAGGTGCTCCCTGGGGTAGGGCAGTGGGGGCAGCCGCCTAATGGGGCTGCGGTGTCCCCTGG
CAGAGCCAGCCCAGGCCTCTGGCCCCTATGTGGAGATCATTGAGCAGCCCAAGCAGCGGGGCATGCGCTTCCGCTACAAG
TGCGAGGGGCGCTCCGCGGGCAGCATCCCAGGCGAGAGGAGCACAGATACCACCAAGACCCACCCCACCATCAAGGTCAG
CACTGCGCCAGGGTGTGCGGGGAAGGGACTGTGGAACCCCAGCCCTCTGTGTTTGGGAGTCAGGTTTGGATGTCTGGGCC
TCTGTACTTTGGACAGATCAATGGCTACACAGGACCAGGGACAGTGCGCATCTCCCTGGTCACCAAGGACCCTCCTCACC
GGCCTCACCCCCACGAGCTTGTAGGAAAGGACTGCCGGGATGGCTTCTATGAGGCTGAGCTCTGCCCGGACCGCTGCATC
CACAGGTGAGGTCCCTGCAGGCTAGGAGGCCCAGCATGAGGGGACAGGAGGCGGGCTATGAAGTAGCCGCTACAGTGTTA
CTCCTTTCTGGACCCAGGGCAGAATTCCTCACTCCTTGCCCTGACTCAGCTCTGCAAGTAAACTGCCTTTGTCTTGAAAT
TATCTATTTGTACGTTTACTCTAGCAGATGAGTTCCAGGGGATACGGATGGGTCCCTAATCACTTCTGAATTCCTGACCC
CTGTAGCTGGAAGGACAAGTCCCTCAGAGTCACGTCTCTTGTTTGAGGAAGAAAACCATTGAACCAGCACTCTCCCCTGG
AGTTGACATTGCAGTTGACAGAGACAGGCTGTAAAAAAATATACAGGCCGGGCATAGTGGCTCATGCTTATAATCCTAGC
ACTTCGGGAGGCCAAGGCAGGAAGATCTCTTGAGCCTAGGAATTCAAGACTAGCCAAGGCAACATAGTGAGACCCCATGT
CTACAAAAAATAAGAAATTAGCTGGGTATGGTGGCATGCGCCTATAGTCCCAGGGAGGCTGAGGTGGGAGGATCGCCTGA
GCCCAGGAGGTCACTGCTGCGGCAAGCTATGATTGCACCACTGCACTTGGGTGGCAGGGCGATACCTTGTCTTTTTTTTT
TTTTTTTTTTTTTTAAGAAAGAGTCTTGCTCTGTCCCCAGACTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTC
CACCTTCCGGGTTCATGCCATTCTCCTGCCTCAGCTTCCCGAATAGCTGGGACTACAGGTGCCTGCCACCACGCCTGGCT
AATTTTTTGTATTTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCTGC
CTGTCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGCACCCGGCCCGACACTGTGTCTCTTAAAAATAAA
TAAATACACAGATAAATAAACAAGGTGCTGTCAGAGTAACAGTTTCAGTCCTGAAAATAAAACGAGGTCATAGGATAGAA
GGATAACCTGGGGTGGGGGAGTTAGGGGAGCTGGTGTGTGATGACTTTAGATTGGGAGGTCAGGGAAGGCCTCCCTCAGC
TAAGACTTGAATGGTGAGAAGGAGGAGAGAAGTAGGAAAAGAACATTCCAAGCCGACCAAACAAGTGCAAAGGCCTTGAG
GTGGGAATGAGTGTCCTGTGTTTAGAGAGTGGAAAAGGAGCCCCGGTGGCTGTAAGCAGGGAGCCCACAGGGAGGCTGGC
AGGGGCAGGGGCACGGAGGTGCTTGTCAGCTGAGTGAAGGGACAGGGTTCGTTGCAGCACAGTAGGAAGCCACTGGAGAG
GGTTAGGCATGGAGCGATGATCTAGGGGTGGGCAGAGTAGGAAGGAGCAGGCTGGGCAAGGCAGGAAGGTCTGGGCTCTG
TGAGAGACAGTGGGACAGACGACTGGGGGCGCTCAGTTTCCAGAACCTGGGAATCCAGTGTGTGAAGAAGCGGGACCTGG
AGCAGGCTATCAGTCAGCGCATCCAGACCAACAACAACCCCTTCCAAGGTGAGGGCAAACCTGCCTGCCACACCCGCACC
CTCTGTCACCCTCCCCAGCCCGCCTTTCCTGCATCTCCCTCACTGGCCAAGACACAGTAAAGCTGGAATCTTGGTGCCCA
TTCAGTACTCTCCCACTTTACCACTGGGAAACTGAGTCCCAGGAGGGGACATGACATTCAGGCCACAGTGGAGTCAGTGC
TGGGTTCTGCCTCCTCTAGGACTTGTGTTTCACACACGCACCAGCGGCCCTCCCAGCGCAGAGCTCCCTGCCCCCACTGA
TAGCACCTATATCCCCACTTCCCCTGCTCTCCTGATCGCCTGTTTTCTTGGCAGTTCCTATAGAAGAGCAGCGTGGGGAC
TACGACCTGAATGCTGTGCGGCTCTGCTTCCAGGTGACAGTGCGGGACCCATCAGGCAGGCCCCTCCGCCTGCCGCCTGT
CCTTTCTCATCCCATCTTTGACAATCGTGAGTAGCGAGGGAGACGCAGGAAGGGGAGAGGGTGGGCCTGAATAGGAGGAA
GGGGGTTGGGGTGAGTGTGGCCTGCAAGAGGCGCTCTGGCTTCATTCAATCATCTTGCGTATTTGTCTACTCTTCTCTGC
CCAGCTCTTTGTTGGCTGGGGAGAGAGGGCAAAGAAGACCCAGAGCTGTCCTTGAGGTGTAGCTCTGGCCTGGCAGGAAG
TCTAGCAGAGAGTCTGATGGGAGATGGGCATTTTCAGTATTGTGTGATGAGAAGGTGGTGTGCCCACAACTGCGATAATG
ACTCTAGGAAATGAACTCCCAGGAACAAGATAGTGTTCGAGAATGATGATTCAGTGATGGAAGCCCACAGATGAATTGGG
CTGACTGATCAGCTGCAGTCTTTAGTTAAGTAACCAGCAGGATGAATGGAAATAAAACGAATCTGGAGCCCCAAGGATGG
GAAACCAGGATAAACTGGGGGTCAGGAGGGAAGGGCTCATTGCCAAGGTGGGTATGGACTGGCCTTAAAGATTGCTTTGG
TCAGGTGGAGAAAGAGTGTGATCAGATTGGCACCCACTGGACTATAAGCTCCGGGAGAGCAGAGAGGTTTGGGTTTTGTG
TGTGGTCGTATTCTTGCTTAGATCAGTGTTGAGTGCACAGTAGGCAAATACTTGTTGAATCGGTTGGGGTGAGGAGCTAA
TAAGAAGGTCTGACTTTGGCTACAAAGGTGTAGGTGGCAAGCTCTGGGCAACCTTGACTCTGGGCTGGGCAGGGAAGTTG
CATCTCCTGCAGGCCACCCTGGGGACCTCTCGTGGCTCAGGTCATCCTCCCTTGTTTTCACTGCCTCAGGTGCCCCCAAC
ACTGCCGAGCTCAAGATCTGCCGAGTGAACCGAAACTCTGGCAGCTGCCTCGGTGGGGATGAGATCTTCCTACTGTGTGA
CAAGGTGCAGAAAGGTATACATCAGGAGGCAGGGGTGGGCTCTTGGGAGCAAGGGGTGAAGCTGAGCAGAGAAGTGGAGT
GTCAGGTAACTGGCTTTGGATACTTCCTCCTGTGCCTCGGGGGCCTCAGGTGGGCCGAAGGGTGATGTATCAGAAGACAA
GCATCAGAAGTTGAGGGGGAGACCATGGAGGGTTAGACACACTGACCCACACTGCCACCGCATCTCCTGCAGAGGACATT
GAGGTGTATTTCACGGGACCAGGCTGGGAGGCCCGAGGCTCCTTTTCGCAAGCTGATGTGCACCGACAAGTGGCCATTGT
GTTCCGGACCCCTCCCTACGCAGACCCCAGCCTGCAGGCTCCTGTGCGTGTCTCCATGCAGCTGCGGCGGCCTTCCGACC
GGGAGCTCAGTGAGCCCATGGAATTCCAGTACCTGCCAGATACAGGTACACAGCTGGGGTGGCAGCATCAGGGCAGCTGG
GCTCTGTGCCGTGAGAGAGAGGCCAAGACTGCATGTCTGGGGCTGTGGTTGAGGGCCAGAAGCTGGAGTCAGAGCTTGGG
ATCCAAGAAACTGGAATCCATTTCTTGCCTCATTTAATAATAATGATACCTCAGACATTGAGCTAGTACTACACATCTGC
CCCTATTCCAGGCACTTCACTGGATTACCTGATTTTAATCTCATGACCCTTTTGAAGTAGGAGATAGTGTCCAACTTGCC
TGGGTTCACGTGGCTAGTAAGTAGCAGAGTCTAGCAGAGTCAGCGTTGGAACCCAGGCCATCTGGCTTCAGGATCCTTTT
GCCACACTGGTTGTCTTGTCACTACCATACAGCCCAGCCACATTTTGGTCGAGGTTTGAGTGTCCACTTGGTACCAGGGC
CTGTGCCAGGTATTGTGAATACAAAAAATGAGTAAGACATGCTCCCTGCCCTTCAGAGTCTCAGTCACTTGAGGAAGACA
AATGTGCAAAACAGATCCTTAAGTCACGGAATGACATGTGAAATGGAGGTGTGCGCAGAGAAGCACGGGGGCACAGTGGC
CTCCGGGGAGCTGGAGACAGCTGCATGGAGAAGGTGGCATTGAAGCTGGAGAAAGACACAGAAGTGTGTTCTCCAGGCAG
GTGGCCCAGCACCTGGAAGGGAAGGGGTGTTGGCAACTGCACGGCCTATTCAGGGCCACCTTCGTGGTTTGAGCTGATGT
TGGGCAGTGAGCAGGCTCAGAGATTGGAGGGCCTGGTTAAGCTGAAGGCCTCTAAGCAGAGAGGTGACAGGAGCAGATTT
GGAAGTTGACTCAGGAGGCCACGTGTAGAAGATCAGAGACAGACAGACTCAAAGCAGGGAGGCCATTCTGGAAATGTTGC
TGTAGTCCAGGAAGAGAAGATGCGGCACAAACCTTACAGAAGGAATAGCAGAGCAAGATCACATCTCCACCACTGTCCTC
AGTTACCCTTCAGCCCTGCAGCCGTTTTGCGTCTTACAGACCAAGCTCAGTCTCACCTCAGGACCTGTGTCTAGCTGTTG
CCTCTGCTTGGAATGCCCAAGGTTTTAATGCAAGTGGCTCATGCCAGTCCTTCCCTGACCTCTAAATTAGCCCTTCCCTC
TACATTTAGACTGTCCTGACCTCACTTCCAGTATTGTTACATCACCATATCGTCCCTGGACCACCGTCACTTGAGATTTT
CTGGTTTGGTTTTGTTTGTTTGTTTGAGACAGAGTCTCACTCTTGTCGCCCAGGCTGGAGTGCAGTGGTGCAATCTCGGC
TCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGC
CACCACATCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTTCACCATGTTGGCCAGGGTGGTCTCGATCTCTTG
ACCTCGTGATCCACCCGCCTCGACCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCGAGATTTTCTG
GTTTGTATATATGATTGTGTCCCTCTCACTTTTTCACTAGGATGCCAACTTTTTGGGAGCAGACACCTTGTGTGCATACT
CACGGCCACATCCCCAGTGTCTAGAAGGGAGGCTGGCACATAGTAGGTGCTTGATAAATATATGTCAAGTTACTGGCGGG
GAGTGAGAGAAAAGAAGATAATCATTCCAAGGTTTCTAGCTTTGGTGACAGGGCAGATGGCGGATGGTCAGGGAATGCAG
GAGAAAGAACCTAGTTTTTGAGGGATGATGAGGTTGTCTTTGAATTGATGGAATTGAAGTGCTTTGGAGCTACTGAAATA
CCACTGTAATTAGAAAGACAGTTCTGAAAGCTCTGACTAAAATATGAAACCATTAGAGATAAGAATAAGAGTCTCTGCTG
AAGTCTTAAGGCAGTTGTGCCTCAGCTGCCCCAGAGTGCCAAGAAATTCTCGCCAGGCCTGGGTGGAGGCTGACAATGAG
CCAGGATGTGAGCAGTGCAGGAAGGTGTGAGCTGGAGGCTGGGGCCCCCCAGGTCTCCTCTTTGCCCAGAGCATGGCCCC
TGTACTCGGCCTCACCATGTGGTCTTAGAGGGGCAGATTCAGCCAACAGAGGCCTCCAAAAGCTGTGGGATTCTCAGAAC
TGCTGAGTGTCACACATCCCTTCTCATTGGCAGAGAAGGTTGGGAGAATGGGTCTTGGGAAAGCCTGGCTCCTCCCCTTC
CTCCTGAGGGACCTTTGAGAGCGTCGGGGACCCACCTGAGGAGAGCAAGTCCCACTTCTCCCCCTTACTTTCCCAGACGA
TCGTCACCGGATTGAGGAGAAACGTAAAAGGACATATGAGACCTTCAAGAGCATCATGAAGAAGAGTCCTTTCAGCGGTG
AGATGGGGACTGGGAAAGCCAGAGAGGAAGGCAGCGGGCAGGGAGGGGACACCCTGGGGCTGAGAACTGACCTAGCCCTT
GCCCTACAGGACCCACCGACCCCCGGCCTCCACCTCGACGCATTGCTGTGCCTTCCCGCAGCTCAGCTTCTGTCCCCAAG
CCAGGTAAGGATTTCCTTTTGTCCCACTGGAACGACAGGTTCAGCTCTGTTCAGCTGAGGAGCAGTGGAGATGAAGACTC
CTGGGCCCCATTACAGACCTACTGAATCAGAGGCTTTGAAAGGATGGCGCAGGAACCAGCGACTTCCTGGGATGCTAATG
CACACTGAAGCCTGGGAACCACCGTGCCACTTAAATTCTATATTGGGTATCTTGGGAATCAGAAGTTAAAAATGCAGAAT
CTCTGCTCTCATCTCTCACTTGAATTGGGGGAACAAAAATCACCTCTAAATTAGCAAGATGTGTGTGCCTGTGCGAGGCT
CAAAAACTGACAAGCTCTGCACTTCAGGCCGCTGCTCACTTGGTGCTCCATGGGCTCATTGCCTCTCAGGACTTAGTTTT
TCAGCTGTAAACTGAGGAGTCCAGCTTATCTCTCCAAGTGTCCCTTCCTCTAAAAGGCTGGAAGAGTTTCGTGGGCTTGA
GTAGTCAGGGAGGACTCCAAGGTGGAGGTGTGGCTAGAACTGGACCCTACAGGCTGGGTCAGATGGGGTAAGAGGAAGGA
GATAGGGTGTTGGCAGTGACTCCCTAGAGAGGGATTGAGCCTGAGCACCATGAAGAGGGGCTGGGGTACAGAGGACGGGG
TGGATCTCTAGGGCTTTCTCTGACCCCTGCCTCTCTGTCTCTCTCCTCCAGCACCCCAGCCCTATCCCTTTACGTCATCC
CTGAGCACCATCAACTATGATGAGTTTCCCACCATGGTGTTTCCTTCTGGGCAGATCAGCCAGGCCTCGGCCTTGGCCCC
GGCCCCTCCCCAAGTCCTGCCCCAGGCTCCAGCCCCTGCCCCTGCTCCAGCCATGGTATCAGCTCTGGCCCAGGCCCCAG
CCCCTGTCCCAGTCCTAGCCCCAGGCCCTCCTCAGGCTGTGGCCCCACCTGCCCCCAAGCCCACCCAGGCTGGGGAAGGA
ACGCTGTCAGAGGCCCTGCTGCAGCTGCAGTTTGATGATGAAGACCTGGGGGCCTTGCTTGGCAACAGCACAGACCCAGC
TGTGTTCACAGACCTGGCATCCGTCGACAACTCCGAGTTTCAGCAGCTGCTGAACCAGGGCATACCTGTGGCCCCCCACA
CAACTGAGCCCATGCTGATGGAGTACCCTGAGGCTATAACTCGCCTAGTGACAGGGGCCCAGAGGCCCCCCGACCCAGCT
CCTGCTCCACTGGGGGCCCCGGGGCTCCCCAATGGCCTCCTTTCAGGAGATGAAGACTTCTCCTCCATTGCGGACATGGA
CTTCTCAGCCCTGCTGAGTCAGATCAGCTCCTAAGGGGGTGACGCCTGCCCTCCCCAGAGCACTGGGTTGCAGGGGATTG
AAGCCCTCCAAAAGCACTTACGGATTCTGGTGGGGTGTGTTCCAACTGCCCCCAACTTTGTGGATGTCTTCCTTGGAGGG
GGGAGCCATATTTTATTCTTTTATTGTCAGTATCTGTATCTCTCTCTCTTTTTGGAGGTGCTTAAGCAGAAGCATTAACT
TCTCTGGAAAGGGGGGAGCTGGGGAAACTCAAACTTTTCCCCTGTCCTGATGGTCAGCTCCCTTCTCTGTAGGGAACTCT
GGGGTCCCCCATCCCCATCCTCCAGCTTCTGGTACTCTCCTAGAGACAGAAGCAGGCTGGAGGTAAGGCCTTTGAGCCCA
CAAAGCCTTATCAAGTGTCTTCCATCATGGATTCATTACAGCTTAATCAAAATAACGCCCCAGATACCAGCCCCTGTATG
GCACTGGCATTGTCCCTGTGCCTAACACCAGCGTTTGAGGGGCTGGCCTTCCTGCCCTACAGAGGTCTCTGCCGGCTCTT
TCCTTGCTCAACCATGGCTGAAGGAAACCAGTGCAACAGCACTGGCTCTCTCCAGGATCCAGAAGGGGTTTGGTCTGGGA
CTTCCTTGCTCTCCCTCTTCTCAAGTGCCTTAATAGTAGGGTAAGTTGTTAAGAGTGGGGGAGAGCAGGCTGGCAGCTCT
CCAGTCAGGAGGCATAGTTTTTACTGAACAATCAAAGCACTTGGACTCTTGCTCTTTCTACTCTGAACTAATAAATCTGT
TGCCAAGCTGGCTAGAG