|
Feature key |
Position
|
Length
|
Description
|
Feature identifier
|
Molecule processing
|
|
|
|
|
|
Signal
|
1 - 23
|
23
|
|
P13500-SIGNAL-1
|
Sites
|
|
|
|
|
|
Site
|
31 - 31
|
1
|
Involved in dimerization
|
P13500-SITE-31
|
|
Site
|
36 - 36
|
1
|
Involved in dimerization, receptor binding and signaling
|
P13500-SITE-36
|
|
Site
|
41 - 41
|
1
|
Involved in GAG binding
|
P13500-SITE-41
|
|
Site
|
42 - 42
|
1
|
Involved in GAG binding
|
P13500-SITE-42
|
|
Site
|
47 - 47
|
1
|
Involved in GAG binding and receptor binding
|
P13500-SITE-47
|
|
Site
|
58 - 58
|
1
|
Involved in dimerization
|
P13500-SITE-58
|
|
Site
|
61 - 61
|
1
|
Involved in dimerization
|
P13500-SITE-61
|
|
Site
|
72 - 72
|
1
|
Involved in GAG binding and receptor binding
|
P13500-SITE-72
|
|
Site
|
81 - 81
|
1
|
Involved in GAG binding
|
P13500-SITE-81
|
|
Site
|
89 - 89
|
1
|
Involved in GAG binding
|
P13500-SITE-89
|
Amino acid modifications
|
|
|
|
|
|
Disulfide bond
|
34 - 59
|
26
|
|
P13500-DISULFID-34
|
|
Disulfide bond
|
35 - 75
|
41
|
|
P13500-DISULFID-35
|
|
Glycosylation
|
37 - 37
|
1
|
N-linked (GlcNAc...) (Potential)
|
P13500-CARBOHYD-37
|
|
Modified residue
|
24 - 24
|
1
|
Pyrrolidone carboxylic acid
|
P13500-MOD_RES-24
|
Experimental info
|
|
|
|
|
|
Mutagenesis
|
24 - 24
|
1
|
Missing: Loss of activity
|
P13500-MUTAGEN-24
|
|
Mutagenesis
|
25 - 31
|
7
|
Missing: Loss of signaling
|
P13500-MUTAGEN-25
|
|
Mutagenesis
|
26 - 26
|
1
|
D->A: Reduction in activity
|
P13500-MUTAGEN-26
|
|
Mutagenesis
|
28 - 28
|
1
|
I->A: Slight reduction in activity
|
P13500-MUTAGEN-28
|
|
Mutagenesis
|
29 - 29
|
1
|
N->A: 50% reduction in activity
|
P13500-MUTAGEN-29
|
|
Mutagenesis
|
31 - 31
|
1
|
P->A: Loss of dimerization; slight reduction of activity
|
P13500-MUTAGEN-31
|
|
Mutagenesis
|
32 - 32
|
1
|
V->E: Slight reduction in affinity
|
P13500-MUTAGEN-32
|
|
Mutagenesis
|
33 - 33
|
1
|
T->E: Slight reduction in affinity
|
P13500-MUTAGEN-33
|
|
Mutagenesis
|
36 - 36
|
1
|
Y->A: Loss of activity
|
P13500-MUTAGEN-36
|
|
Mutagenesis
|
47 - 47
|
1
|
R->F: 95% reduction in activity; strong reduction of receptor binding
|
P13500-MUTAGEN-47
|
|
Mutagenesis
|
50 - 50
|
1
|
S->Q: 40% reduction in activity
|
P13500-MUTAGEN-50
|
|
Mutagenesis
|
51 - 51
|
1
|
Y->D: Loss of activity
|
P13500-MUTAGEN-51
|
|
Mutagenesis
|
53 - 53
|
1
|
R->L: Loss of activity
|
P13500-MUTAGEN-53
|
|
Mutagenesis
|
79 - 79
|
1
|
K->A: No effect on heparin binding
|
P13500-MUTAGEN-79
|
|
Mutagenesis
|
81 - 81
|
1
|
K->A: Strongly reduces heparin binding
|
P13500-MUTAGEN-81
|
|
Mutagenesis
|
89 - 89
|
1
|
H->A: Strongly reduces heparin binding
|
P13500-MUTAGEN-89
|
|
Mutagenesis
|
91 - 91
|
1
|
D->L: 90% reduction in activity
|
P13500-MUTAGEN-91
|
|
Mutagenesis
|
95 - 99
|
5
|
Missing: No effect on heparin binding
|
P13500-MUTAGEN-95
|
