(MLST8) MTOR associated protein, LST8 homolog (S. cerevisiae) [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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8585
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Official symbol
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MLST8
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Official name
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MTOR associated protein, LST8 homolog (S. cerevisiae)
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 16 (NC_000016.9) : 2255449...2259417 (+)
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Map
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16p13.3
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Length
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3969 nt
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NM_022372.3
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MLST8, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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Q9BVC4
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Target of rapamycin complex subunit LST8
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Homo sapiens
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326 aa
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D3DU88
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G protein beta subunit-like, isoform CRA_b [submitted name]
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Homo sapiens
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326 aa
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Synonyms |
WAT1; MGC111011; Pop3; Lst8; GBL; GbetaL
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Alternative name(s) |
mTOR associated protein, LST8 homolog (S. cerevisiae); G protein beta subunit like
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Related Articles in PubMed
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Go to ensembl
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1 |
TCGATCGACT |
CGCTCCGGCT |
CCCCTCGCCG |
TCCTGGACAC |
GGCGGAGTGC |
GGAGCCGCCC |
GTAAGGTACG |
GAGGCCGCGA |
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81 |
GCCAGGGGCC |
GGGAACCGGC |
TGCTGGGTGG |
CTGGGAGAGC |
ACGGCCAGGG |
GAAGCCGGCC |
AGCAGGACGG |
AGCAAGGGCG |
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161 |
GTCACCGGAG |
GAAAGGGGAG |
CTCGGGGGTC |
CAGCCAGACT |
GCGCCCTTTC |
CCATCAGGGC |
CTGCCGCTGG |
CCTGCTACGC |
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241 |
ATGCGCAGCC |
GCAGCGCTCG |
GCTTTCCCCG |
GCCCATCCGC |
CGCCTTGCGC |
ACGCGCAGCC |
CGCCCCTGCG |
GCAGAGTGGC |
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321 |
GCCCGCGCGT |
GACTCCCCCC |
TGCCGGCTGC |
GGAGGTGGGG |
GGGGGACGGC |
GCCCCCGCCG |
TGTGCGTGGG |
GCGGGGATGG |
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401 |
AGCACGCGCC |
CTGGAGCCCC |
GGAGCCAGGT |
ATCACGCGTG |
TGACGCGTGT |
CCCTGAACCT |
ACCTGCGCTT |
CTTGTCCCAA |
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481 |
CTCTAAAATG |
GGAATGATAA |
GCGCCATTCG |
GCAGCGCCTT |
GTGGGTCTAT |
AATCTACTTA |
GCACAGAGAG |
TGTCTTCTAA |
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561 |
GTACTTCACA |
TCCTTCTCTG |
CAGATGCTCT |
GACCTTTGAC |
CCCTGCCGTT |
CAGCTCTAGG |
GCCCGTGCAG |
GCCACACCAT |
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641 |
GAACACCTCC |
CCAGGCACGG |
TGGGCAGTGA |
CCCGGTCATC |
CTGGCCACTG |
CAGGCTACGA |
CCACACCGTG |
CGCTTCTGGC |
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721 |
AGGCCCACAG |
CGGCATCTGC |
ACCCGGACGG |
TGCAGCACCA |
GGACTCCGTA |
TCCTCCACCC |
GGGGCGGGCA |
GGGCGGCGCT |
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801 |
GGGGGGATGC |
CTCGTGTGGG |
GACCACAGCC |
TGTGTGAAGG |
CCAGATGGTG |
GAGGCCTGGG |
GGGCCCTGGC |
CTCAGGGCTA |
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881 |
CCTTCCCGTC |
ATCCTCCTTA |
ACAGTCCCAG |
CAGGTGAATG |
CCTTGGAGGT |
CACACCGGAC |
CGCAGCATGA |
TTGCTGCTGC |
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961 |
AGGTATCTGT |
GATCCTTGAT |
CTCTAAACTC |
CTGAGCTCTG |
GTGGGTCGAC |
CTCAGCACAG |
CCAAGCTTCA |
GTTCAGCCTG |
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1041 |
TGTCCCTAGG |
TTACCAGCAC |
ATCCGCATGT |
ATGATCTCAA |
CTCCAATAAC |
CCTAACCCCA |
TCATCAGCTA |
CGACGGCGTC |
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1121 |
AACAAGAACA |
TCGCGTCTGT |
GGGCTTCCAC |
GAAGACGGCC |
GCTGGATGTA |
CACGGGCGGC |
GAGGACTGCA |
CAGCCAGGAT |
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1201 |
CTGGGACCTC |
AGGTGCGGTG |
GGGAGGGGGC |
GTGCTGCCCG |
GGGCTGGGGT |
GGGCTGCTCT |
GGGAGACCGT |
TTTAGGTTGG |
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1281 |
GTTCTCTTCA |
AGCAGAGGCT |
GAGACAGGGA |
GCTTCCTGTG |
GGCGACTTAC |
TGAGAGAAGT |
GAGGACAGGA |
GGAGAGTGAA |
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1361 |
TTGCATCAGA |
GCGCGAGTCC |
TGCCTTGAGC |
CCGGAGCCAG |
CTTGTTATTC |
CCCTTCCACC |
AGCCACTGGC |
TTAGGCTCCC |
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1441 |
TGCTGGAGCA |
GAGGGCCCTG |
CGTCCCAAGT |
ATTTCCCAAG |
AGGCAGGTCC |
TTCAGCAGAG |
GGAGGGGAGG |
AATGGCCAGG |
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1521 |
CCGAGGCCAT |
CTGGGTAGGG |
CACCAACAAG |
CCCAGATGGA |
CAGCATGTGC |
CCCGGCCCGG |
CCCGCAGGTC |
CCGGAACCTG |
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1601 |
CAGTGCCAGC |
GGATCTTCCA |
GGTGAACGCA |
CCCATTAACT |
GCGTGTGCCT |
GCACCCCAAC |
CAGGTGAGGG |
GTGCTCATGG |
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1681 |
GGCCAGGCAC |
CCTGGGACTT |
TGGAGGGCTG |
GGCTTGGGCC |
CTGCCTCACC |
ACCCCTGCAC |
CCCAGGCAGA |
GCTCATCGTG |
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1761 |
GGTGACCAGA |
GCGGGGCTAT |
CCACATCTGG |
GACTTGAAAA |
CAGACCACAA |
CGAGCAGCTG |
ATCCCTGAGC |
CCGAGGTCTC |
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1841 |
CATCACGTCC |
GCCCACATCG |
ATCCCGACGC |
CAGCTACATG |
GCAGCTGTCA |
ATAGCACCGT |
GAGTCCTGGT |
GGCAGGTGCT |
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1921 |
GGGTGCGGGC |
AGCTTGGCAC |
TCAGCCCTCA |
GCCTCTGCAG |
GTGGGCTTAT |
TCCTGGATGT |
CCCTTAGCGG |
CCCCCTCCTG |
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2001 |
CTTTCCCCAT |
CCCGGGCACT |
AACACCCACC |
TTGCCAGCAA |
AGCCAGAAGC |
CTTAGTGTCG |
CTCCCGATGG |
CTTAGTCCTG |
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2081 |
TCTGCAGGTC |
GGTCACTCCG |
CTTTCTGGAG |
TCTCTCCCAA |
GTCGATCCAC |
TTCCCTCTTT |
TCACTCTGTT |
GCCTCCTGGT |
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2161 |
CCCAGTCACC |
CTTGTTTCTG |
GTGACGGCTG |
ACACACTCTC |
TGAGGCTTCC |
TTTCCCCCTC |
CCTGACCTCC |
CCTGGCCCCT |
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2241 |
GACACGTTCT |
CTCTTGGATG |
CTTCTAGTGG |
TGCCTGGTCA |
GTATCAGCCA |
GGTGGCGTCA |
TTCCCCTGAG |
GAGACCCGGG |
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2321 |
GCTGCTGGCC |
TCGCCCGTAG |
GCTGCTGTGG |
CGTGGCCCCT |
GCTCTTCTCT |
CCAGCCTCAT |
TTTTTTTCAT |
TAACTTCATT |
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2401 |
TAATCCCAGT |
GCATCACTTG |
TACCTCTTGC |
CCCCGGATTT |
CCCTTCTGCT |
GGCCTTTGTC |
ATGCTGTCTC |
TCTAGCTGGT |
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2481 |
GCCCTTCTCC |
TGTCTACTTC |
CGTTGGCCAT |
CGGCATCCTC |
CAGGAAGGAG |
AATTTGAGTC |
CTTGGCCAGG |
CGTGGCCTCC |
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2561 |
TGTTCTTGGC |
TTGCCAGGTG |
TGGCCCTTGC |
TTGGGGCCAG |
GCTTCCCAGG |
TGCCTTCTGC |
AGGCAGGACC |
AGAGGGGCCT |
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2641 |
GCCTGCCCCT |
CACCCGGGGT |
CCCCATGCAC |
AGTTGGCCCC |
CAGTGTTGGC |
CCCCAGGGCA |
TCCTTCCCTG |
TGTCTCAGAC |
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2721 |
CTGAGGCCTT |
GGGCCCTCCG |
TGACGGTCCT |
CCTGACCTCT |
AGGGAAACTG |
CTATGTCTGG |
AATCTGACGG |
GGGGCATTGG |
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2801 |
TGACGAGGTG |
ACCCAGCTCA |
TCCCCAAGAC |
TAAGATCCCT |
GCCCACACGC |
GCTACGCCCT |
GCAGTGTCGC |
TTCAGCCCCG |
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2881 |
ACTCCACGTG |
CGTGCAGGGC |
CTGCTGGCCC |
GGGAGGGGAC |
CTGCCTGGGC |
TGGGGGCTGG |
AGAGGGGAGG |
GGCTGCTGGA |
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2961 |
TGGAGTGGCT |
GCTGCTGGAC |
ACGCCCCATG |
CCCACCCACT |
AGGCTCCTCG |
CCACCTGCTC |
GGCTGATCAG |
ACGTGCAAGA |
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3041 |
TCTGGAGGAC |
GTCCAACTTC |
TCCCTGATGA |
CGGAGCTGAG |
CATCAAGAGC |
GGCAACCCCG |
GGGAGTCCTC |
CCGCGGCTGG |
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3121 |
ATGTGGGGCT |
GCGCCTTCTC |
GGGGGACTCC |
CAGTACATCG |
TCACTGGTGA |
GCCCCGCCCT |
GGCCTCCCCC |
ATCCCTGGCC |
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3201 |
CCCGGCGCTG |
GCCTCCAGAG |
CCAGCCCACC |
TCGGCTGCAG |
CTTCCCCTCT |
GCTGGGGCCG |
CCTGCTTGGC |
CTGCACCTGC |
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3281 |
GCTCTTAGCC |
CTGCACAATC |
TCCCCCTCCA |
GCTTCCTCGG |
ACAACCTGGC |
CCGGCTCTGG |
TGTGTGGAGA |
CTGGAGAGAT |
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3361 |
CAAGAGAGAG |
TATGGCGGCC |
ACCAGAAGGC |
TGTTGTCTGC |
CTGGCCTTCA |
ATGACAGTGT |
GCTGGGCTAG |
CCTGTGACCC |
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3441 |
CTCGGGACTG |
CCTGGTGCAG |
GTGGTGGCAG |
CTGGAGGGAC |
CCATGCAGCA |
CCCAGGTCAG |
AGCAGACCCT |
CCCCTGCCGG |
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3521 |
CCTGCGCCAG |
CTGGACCTGA |
TGGCCCCCTG |
TGGCGCCTTG |
ACCTGCTGGG |
CCAGGCTGCC |
CTGGGACTCT |
CAGCCCCCAG |
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3601 |
TTGCTTATCC |
AGATGTGACA |
GAGCTCGACC |
CAAGCCAGGC |
TGCACACTCC |
TGGACTGGGC |
TAGCCTGCAC |
TGCCTGGGAA |
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3681 |
AGTCGGCCGA |
GGGCCCAAAG |
CTGCTGAGGG |
GTCTGAGGCT |
GGTGCCCACC |
CCCAAGCTAG |
TGTGTTCTCT |
GCCCCTCCCT |
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3761 |
GCCCGCGTTT |
CAGGGCCTCG |
GTCCATAGAG |
AACACCACCA |
CCATGGCCAG |
GTGGAAGGGT |
TTATTAGTCC |
CTGCCAGCAG |
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3841 |
CTGTCCTCCC |
TGGTGCAGGT |
GGCCTGGCCA |
GCCCACTGGA |
TTGGGGACGG |
GCCAGGCTGG |
GCCAGGTCGG |
GGGCTCAGTC |
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3921 |
TGGGAGGTAA |
TAAAAGCAGA |
CCGACACGCA |
GATGTTGCTC |
GGGAAGCAG |
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>ref|Gene_ID:64223|MLST8|NC_000016.9:2255449...2259417 (+)
TCGATCGACTCGCTCCGGCTCCCCTCGCCGTCCTGGACACGGCGGAGTGCGGAGCCGCCCGTAAGGTACGGAGGCCGCGA
GCCAGGGGCCGGGAACCGGCTGCTGGGTGGCTGGGAGAGCACGGCCAGGGGAAGCCGGCCAGCAGGACGGAGCAAGGGCG
GTCACCGGAGGAAAGGGGAGCTCGGGGGTCCAGCCAGACTGCGCCCTTTCCCATCAGGGCCTGCCGCTGGCCTGCTACGC
ATGCGCAGCCGCAGCGCTCGGCTTTCCCCGGCCCATCCGCCGCCTTGCGCACGCGCAGCCCGCCCCTGCGGCAGAGTGGC
GCCCGCGCGTGACTCCCCCCTGCCGGCTGCGGAGGTGGGGGGGGGACGGCGCCCCCGCCGTGTGCGTGGGGCGGGGATGG
AGCACGCGCCCTGGAGCCCCGGAGCCAGGTATCACGCGTGTGACGCGTGTCCCTGAACCTACCTGCGCTTCTTGTCCCAA
CTCTAAAATGGGAATGATAAGCGCCATTCGGCAGCGCCTTGTGGGTCTATAATCTACTTAGCACAGAGAGTGTCTTCTAA
GTACTTCACATCCTTCTCTGCAGATGCTCTGACCTTTGACCCCTGCCGTTCAGCTCTAGGGCCCGTGCAGGCCACACCAT
GAACACCTCCCCAGGCACGGTGGGCAGTGACCCGGTCATCCTGGCCACTGCAGGCTACGACCACACCGTGCGCTTCTGGC
AGGCCCACAGCGGCATCTGCACCCGGACGGTGCAGCACCAGGACTCCGTATCCTCCACCCGGGGCGGGCAGGGCGGCGCT
GGGGGGATGCCTCGTGTGGGGACCACAGCCTGTGTGAAGGCCAGATGGTGGAGGCCTGGGGGGCCCTGGCCTCAGGGCTA
CCTTCCCGTCATCCTCCTTAACAGTCCCAGCAGGTGAATGCCTTGGAGGTCACACCGGACCGCAGCATGATTGCTGCTGC
AGGTATCTGTGATCCTTGATCTCTAAACTCCTGAGCTCTGGTGGGTCGACCTCAGCACAGCCAAGCTTCAGTTCAGCCTG
TGTCCCTAGGTTACCAGCACATCCGCATGTATGATCTCAACTCCAATAACCCTAACCCCATCATCAGCTACGACGGCGTC
AACAAGAACATCGCGTCTGTGGGCTTCCACGAAGACGGCCGCTGGATGTACACGGGCGGCGAGGACTGCACAGCCAGGAT
CTGGGACCTCAGGTGCGGTGGGGAGGGGGCGTGCTGCCCGGGGCTGGGGTGGGCTGCTCTGGGAGACCGTTTTAGGTTGG
GTTCTCTTCAAGCAGAGGCTGAGACAGGGAGCTTCCTGTGGGCGACTTACTGAGAGAAGTGAGGACAGGAGGAGAGTGAA
TTGCATCAGAGCGCGAGTCCTGCCTTGAGCCCGGAGCCAGCTTGTTATTCCCCTTCCACCAGCCACTGGCTTAGGCTCCC
TGCTGGAGCAGAGGGCCCTGCGTCCCAAGTATTTCCCAAGAGGCAGGTCCTTCAGCAGAGGGAGGGGAGGAATGGCCAGG
CCGAGGCCATCTGGGTAGGGCACCAACAAGCCCAGATGGACAGCATGTGCCCCGGCCCGGCCCGCAGGTCCCGGAACCTG
CAGTGCCAGCGGATCTTCCAGGTGAACGCACCCATTAACTGCGTGTGCCTGCACCCCAACCAGGTGAGGGGTGCTCATGG
GGCCAGGCACCCTGGGACTTTGGAGGGCTGGGCTTGGGCCCTGCCTCACCACCCCTGCACCCCAGGCAGAGCTCATCGTG
GGTGACCAGAGCGGGGCTATCCACATCTGGGACTTGAAAACAGACCACAACGAGCAGCTGATCCCTGAGCCCGAGGTCTC
CATCACGTCCGCCCACATCGATCCCGACGCCAGCTACATGGCAGCTGTCAATAGCACCGTGAGTCCTGGTGGCAGGTGCT
GGGTGCGGGCAGCTTGGCACTCAGCCCTCAGCCTCTGCAGGTGGGCTTATTCCTGGATGTCCCTTAGCGGCCCCCTCCTG
CTTTCCCCATCCCGGGCACTAACACCCACCTTGCCAGCAAAGCCAGAAGCCTTAGTGTCGCTCCCGATGGCTTAGTCCTG
TCTGCAGGTCGGTCACTCCGCTTTCTGGAGTCTCTCCCAAGTCGATCCACTTCCCTCTTTTCACTCTGTTGCCTCCTGGT
CCCAGTCACCCTTGTTTCTGGTGACGGCTGACACACTCTCTGAGGCTTCCTTTCCCCCTCCCTGACCTCCCCTGGCCCCT
GACACGTTCTCTCTTGGATGCTTCTAGTGGTGCCTGGTCAGTATCAGCCAGGTGGCGTCATTCCCCTGAGGAGACCCGGG
GCTGCTGGCCTCGCCCGTAGGCTGCTGTGGCGTGGCCCCTGCTCTTCTCTCCAGCCTCATTTTTTTTCATTAACTTCATT
TAATCCCAGTGCATCACTTGTACCTCTTGCCCCCGGATTTCCCTTCTGCTGGCCTTTGTCATGCTGTCTCTCTAGCTGGT
GCCCTTCTCCTGTCTACTTCCGTTGGCCATCGGCATCCTCCAGGAAGGAGAATTTGAGTCCTTGGCCAGGCGTGGCCTCC
TGTTCTTGGCTTGCCAGGTGTGGCCCTTGCTTGGGGCCAGGCTTCCCAGGTGCCTTCTGCAGGCAGGACCAGAGGGGCCT
GCCTGCCCCTCACCCGGGGTCCCCATGCACAGTTGGCCCCCAGTGTTGGCCCCCAGGGCATCCTTCCCTGTGTCTCAGAC
CTGAGGCCTTGGGCCCTCCGTGACGGTCCTCCTGACCTCTAGGGAAACTGCTATGTCTGGAATCTGACGGGGGGCATTGG
TGACGAGGTGACCCAGCTCATCCCCAAGACTAAGATCCCTGCCCACACGCGCTACGCCCTGCAGTGTCGCTTCAGCCCCG
ACTCCACGTGCGTGCAGGGCCTGCTGGCCCGGGAGGGGACCTGCCTGGGCTGGGGGCTGGAGAGGGGAGGGGCTGCTGGA
TGGAGTGGCTGCTGCTGGACACGCCCCATGCCCACCCACTAGGCTCCTCGCCACCTGCTCGGCTGATCAGACGTGCAAGA
TCTGGAGGACGTCCAACTTCTCCCTGATGACGGAGCTGAGCATCAAGAGCGGCAACCCCGGGGAGTCCTCCCGCGGCTGG
ATGTGGGGCTGCGCCTTCTCGGGGGACTCCCAGTACATCGTCACTGGTGAGCCCCGCCCTGGCCTCCCCCATCCCTGGCC
CCCGGCGCTGGCCTCCAGAGCCAGCCCACCTCGGCTGCAGCTTCCCCTCTGCTGGGGCCGCCTGCTTGGCCTGCACCTGC
GCTCTTAGCCCTGCACAATCTCCCCCTCCAGCTTCCTCGGACAACCTGGCCCGGCTCTGGTGTGTGGAGACTGGAGAGAT
CAAGAGAGAGTATGGCGGCCACCAGAAGGCTGTTGTCTGCCTGGCCTTCAATGACAGTGTGCTGGGCTAGCCTGTGACCC
CTCGGGACTGCCTGGTGCAGGTGGTGGCAGCTGGAGGGACCCATGCAGCACCCAGGTCAGAGCAGACCCTCCCCTGCCGG
CCTGCGCCAGCTGGACCTGATGGCCCCCTGTGGCGCCTTGACCTGCTGGGCCAGGCTGCCCTGGGACTCTCAGCCCCCAG
TTGCTTATCCAGATGTGACAGAGCTCGACCCAAGCCAGGCTGCACACTCCTGGACTGGGCTAGCCTGCACTGCCTGGGAA
AGTCGGCCGAGGGCCCAAAGCTGCTGAGGGGTCTGAGGCTGGTGCCCACCCCCAAGCTAGTGTGTTCTCTGCCCCTCCCT
GCCCGCGTTTCAGGGCCTCGGTCCATAGAGAACACCACCACCATGGCCAGGTGGAAGGGTTTATTAGTCCCTGCCAGCAG
CTGTCCTCCCTGGTGCAGGTGGCCTGGCCAGCCCACTGGATTGGGGACGGGCCAGGCTGGGCCAGGTCGGGGGCTCAGTC
TGGGAGGTAATAAAAGCAGACCGACACGCAGATGTTGCTCGGGAAGCAG
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Primary source |
RefSeq : NM_022372.3 (GI:84626577)
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Name |
MTOR associated protein, LST8 homolog (S. cerevisiae) (MLST8)
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
1655 nt
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Map |
16p13.3
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Location |
Chromosome 16 (NC_000016.9) strand : +
2255449...2255512 | 2256031...2256214 | 2256358...2256409 | 2256497...2256659 |
2257035...2257110 | 2257193...2257345 | 2258210...2258334 | 2258450...2258613 |
2258759...2259417 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon
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164
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-
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Exon
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52
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-
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Exon
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64
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-
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Exon
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163
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-
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Exon
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125
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-
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Exon
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659
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-
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Exon
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153
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-
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Exon
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76
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-
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Exon
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184
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-
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Exon 1
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1
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64
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64
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1
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Exon 2
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65
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248
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184
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1
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Exon 3
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249
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300
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52
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1
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Exon 4
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301
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463
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163
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1
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Exon 5
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464
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539
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76
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1
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Exon 6
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540
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692
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153
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1
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Exon 7
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693
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817
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125
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1
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Exon 8
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818
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981
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164
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1
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Exon 9
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982
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1640
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659
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1
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Primary source |
NCBI : CCDS10462
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Nucleotide |
MLST8, mRNA isoform 1[NM_022372.3] : 120...1100
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Length |
981
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Location |
Chromosome 16 (NC_000016.9) strand : +
2256086...2256214 | 2256358...2256409 | 2256497...2256659 | 2257035...2257110 |
2257193...2257345 | 2258210...2258334 | 2258450...2258613 | 2258759...2258877 |
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Start codon |
1
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Translation |
NP_071767.3 |
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1 |
CGATCGACTC |
GCTCCGGCTC |
CCCTCGCCGT |
CCTGGACACG |
GCGGAGTGCG |
GAGCCGCCCG |
TAAGATGCTC |
TGACCTTTGA |
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81 |
CCCCTGCCGT |
TCAGCTCTAG |
GGCCCGTGCA |
GGCCACACCA |
TGAACACCTC |
CCCAGGCACG |
GTGGGCAGTG |
ACCCGGTCAT |
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161 |
CCTGGCCACT |
GCAGGCTACG |
ACCACACCGT |
GCGCTTCTGG |
CAGGCCCACA |
GCGGCATCTG |
CACCCGGACG |
GTGCAGCACC |
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241 |
AGGACTCCCA |
GGTGAATGCC |
TTGGAGGTCA |
CACCGGACCG |
CAGCATGATT |
GCTGCTGCAG |
GTTACCAGCA |
CATCCGCATG |
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321 |
TATGATCTCA |
ACTCCAATAA |
CCCTAACCCC |
ATCATCAGCT |
ACGACGGCGT |
CAACAAGAAC |
ATCGCGTCTG |
TGGGCTTCCA |
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401 |
CGAAGACGGC |
CGCTGGATGT |
ACACGGGCGG |
CGAGGACTGC |
ACAGCCAGGA |
TCTGGGACCT |
CAGGTCCCGG |
AACCTGCAGT |
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481 |
GCCAGCGGAT |
CTTCCAGGTG |
AACGCACCCA |
TTAACTGCGT |
GTGCCTGCAC |
CCCAACCAGG |
CAGAGCTCAT |
CGTGGGTGAC |
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561 |
CAGAGCGGGG |
CTATCCACAT |
CTGGGACTTG |
AAAACAGACC |
ACAACGAGCA |
GCTGATCCCT |
GAGCCCGAGG |
TCTCCATCAC |
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641 |
GTCCGCCCAC |
ATCGATCCCG |
ACGCCAGCTA |
CATGGCAGCT |
GTCAATAGCA |
CCGGAAACTG |
CTATGTCTGG |
AATCTGACGG |
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721 |
GGGGCATTGG |
TGACGAGGTG |
ACCCAGCTCA |
TCCCCAAGAC |
TAAGATCCCT |
GCCCACACGC |
GCTACGCCCT |
GCAGTGTCGC |
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801 |
TTCAGCCCCG |
ACTCCACGCT |
CCTCGCCACC |
TGCTCGGCTG |
ATCAGACGTG |
CAAGATCTGG |
AGGACGTCCA |
ACTTCTCCCT |
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881 |
GATGACGGAG |
CTGAGCATCA |
AGAGCGGCAA |
CCCCGGGGAG |
TCCTCCCGCG |
GCTGGATGTG |
GGGCTGCGCC |
TTCTCGGGGG |
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961 |
ACTCCCAGTA |
CATCGTCACT |
GCTTCCTCGG |
ACAACCTGGC |
CCGGCTCTGG |
TGTGTGGAGA |
CTGGAGAGAT |
CAAGAGAGAG |
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1041 |
TATGGCGGCC |
ACCAGAAGGC |
TGTTGTCTGC |
CTGGCCTTCA |
ATGACAGTGT |
GCTGGGCTAG |
CCTGTGACCC |
CTCGGGACTG |
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1121 |
CCTGGTGCAG |
GTGGTGGCAG |
CTGGAGGGAC |
CCATGCAGCA |
CCCAGGTCAG |
AGCAGACCCT |
CCCCTGCCGG |
CCTGCGCCAG |
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1201 |
CTGGACCTGA |
TGGCCCCCTG |
TGGCGCCTTG |
ACCTGCTGGG |
CCAGGCTGCC |
CTGGGACTCT |
CAGCCCCCAG |
TTGCTTATCC |
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1281 |
AGATGTGACA |
GAGCTCGACC |
CAAGCCAGGC |
TGCACACTCC |
TGGACTGGGC |
TAGCCTGCAC |
TGCCTGGGAA |
AGTCGGCCGA |
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1361 |
GGGCCCAAAG |
CTGCTGAGGG |
GTCTGAGGCT |
GGTGCCCACC |
CCCAAGCTAG |
TGTGTTCTCT |
GCCCCTCCCT |
GCCCGCGTTT |
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1441 |
CAGGGCCTCG |
GTCCATAGAG |
AACACCACCA |
CCATGGCCAG |
GTGGAAGGGT |
TTATTAGTCC |
CTGCCAGCAG |
CTGTCCTCCC |
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1521 |
TGGTGCAGGT |
GGCCTGGCCA |
GCCCACTGGA |
TTGGGGACGG |
GCCAGGCTGG |
GCCAGGTCGG |
GGGCTCAGTC |
TGGGAGGTAA |
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1601 |
TAAAAGCAGA |
CCGACACGCA |
GATGTTGCTC |
GGGAAGCAGA |
AAAAAAAAAA |
AAAAA |
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>gi|84626577|ref|NM_022372.3|MTOR associated protein, LST8 homolog (S. cerevisiae) (MLST8)
CGATCGACTCGCTCCGGCTCCCCTCGCCGTCCTGGACACGGCGGAGTGCGGAGCCGCCCGTAAGATGCTCTGACCTTTGA
CCCCTGCCGTTCAGCTCTAGGGCCCGTGCAGGCCACACCATGAACACCTCCCCAGGCACGGTGGGCAGTGACCCGGTCAT
CCTGGCCACTGCAGGCTACGACCACACCGTGCGCTTCTGGCAGGCCCACAGCGGCATCTGCACCCGGACGGTGCAGCACC
AGGACTCCCAGGTGAATGCCTTGGAGGTCACACCGGACCGCAGCATGATTGCTGCTGCAGGTTACCAGCACATCCGCATG
TATGATCTCAACTCCAATAACCCTAACCCCATCATCAGCTACGACGGCGTCAACAAGAACATCGCGTCTGTGGGCTTCCA
CGAAGACGGCCGCTGGATGTACACGGGCGGCGAGGACTGCACAGCCAGGATCTGGGACCTCAGGTCCCGGAACCTGCAGT
GCCAGCGGATCTTCCAGGTGAACGCACCCATTAACTGCGTGTGCCTGCACCCCAACCAGGCAGAGCTCATCGTGGGTGAC
CAGAGCGGGGCTATCCACATCTGGGACTTGAAAACAGACCACAACGAGCAGCTGATCCCTGAGCCCGAGGTCTCCATCAC
GTCCGCCCACATCGATCCCGACGCCAGCTACATGGCAGCTGTCAATAGCACCGGAAACTGCTATGTCTGGAATCTGACGG
GGGGCATTGGTGACGAGGTGACCCAGCTCATCCCCAAGACTAAGATCCCTGCCCACACGCGCTACGCCCTGCAGTGTCGC
TTCAGCCCCGACTCCACGCTCCTCGCCACCTGCTCGGCTGATCAGACGTGCAAGATCTGGAGGACGTCCAACTTCTCCCT
GATGACGGAGCTGAGCATCAAGAGCGGCAACCCCGGGGAGTCCTCCCGCGGCTGGATGTGGGGCTGCGCCTTCTCGGGGG
ACTCCCAGTACATCGTCACTGCTTCCTCGGACAACCTGGCCCGGCTCTGGTGTGTGGAGACTGGAGAGATCAAGAGAGAG
TATGGCGGCCACCAGAAGGCTGTTGTCTGCCTGGCCTTCAATGACAGTGTGCTGGGCTAGCCTGTGACCCCTCGGGACTG
CCTGGTGCAGGTGGTGGCAGCTGGAGGGACCCATGCAGCACCCAGGTCAGAGCAGACCCTCCCCTGCCGGCCTGCGCCAG
CTGGACCTGATGGCCCCCTGTGGCGCCTTGACCTGCTGGGCCAGGCTGCCCTGGGACTCTCAGCCCCCAGTTGCTTATCC
AGATGTGACAGAGCTCGACCCAAGCCAGGCTGCACACTCCTGGACTGGGCTAGCCTGCACTGCCTGGGAAAGTCGGCCGA
GGGCCCAAAGCTGCTGAGGGGTCTGAGGCTGGTGCCCACCCCCAAGCTAGTGTGTTCTCTGCCCCTCCCTGCCCGCGTTT
CAGGGCCTCGGTCCATAGAGAACACCACCACCATGGCCAGGTGGAAGGGTTTATTAGTCCCTGCCAGCAGCTGTCCTCCC
TGGTGCAGGTGGCCTGGCCAGCCCACTGGATTGGGGACGGGCCAGGCTGGGCCAGGTCGGGGGCTCAGTCTGGGAGGTAA
TAAAAGCAGACCGACACGCAGATGTTGCTCGGGAAGCAGAAAAAAAAAAAAAAAA
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Exon number |
8
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Length |
164 nt
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Location |
Chromosome 16 (NC_000016.9) : -1...-1 ()
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Is part of |
MLST8, mRNA isoform 1
(NM_022372.3)
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Sequence |
Show
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GCTCCTCGCCACCTGCTCGGCTGATCAGACGTGCAAGATCTGGAGGACGTCCAACTTCTCCCTGATGACGGAGCTGAGCA
TCAAGAGCGGCAACCCCGGGGAGTCCTCCCGCGGCTGGATGTGGGGCTGCGCCTTCTCGGGGGACTCCCAGTACATCGTC
ACTG
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Exon number |
4
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Length |
163 nt
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Location |
Chromosome 16 (NC_000016.9) : -1...-1 ()
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Is part of |
MLST8, mRNA isoform 1
(NM_022372.3)
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Sequence |
Show
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GTTACCAGCACATCCGCATGTATGATCTCAACTCCAATAACCCTAACCCCATCATCAGCTACGACGGCGTCAACAAGAAC
ATCGCGTCTGTGGGCTTCCACGAAGACGGCCGCTGGATGTACACGGGCGGCGAGGACTGCACAGCCAGGATCTGGGACCT
CAG
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Exon number |
6
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Length |
153 nt
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Location |
Chromosome 16 (NC_000016.9) : -1...-1 ()
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Is part of |
MLST8, mRNA isoform 1
(NM_022372.3)
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Sequence |
Show
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GCAGAGCTCATCGTGGGTGACCAGAGCGGGGCTATCCACATCTGGGACTTGAAAACAGACCACAACGAGCAGCTGATCCC
TGAGCCCGAGGTCTCCATCACGTCCGCCCACATCGATCCCGACGCCAGCTACATGGCAGCTGTCAATAGCACC
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Exon number |
7
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Length |
125 nt
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Location |
Chromosome 16 (NC_000016.9) : -1...-1 ()
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Is part of |
MLST8, mRNA isoform 1
(NM_022372.3)
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Sequence |
Show
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GGAAACTGCTATGTCTGGAATCTGACGGGGGGCATTGGTGACGAGGTGACCCAGCTCATCCCCAAGACTAAGATCCCTGC
CCACACGCGCTACGCCCTGCAGTGTCGCTTCAGCCCCGACTCCAC
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Exon number |
2
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Length |
184 nt
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Location |
Chromosome 16 (NC_000016.9) : -1...-1 ()
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Is part of |
MLST8, mRNA isoform 1
(NM_022372.3)
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Sequence |
Show
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ATGCTCTGACCTTTGACCCCTGCCGTTCAGCTCTAGGGCCCGTGCAGGCCACACCATGAACACCTCCCCAGGCACGGTGG
GCAGTGACCCGGTCATCCTGGCCACTGCAGGCTACGACCACACCGTGCGCTTCTGGCAGGCCCACAGCGGCATCTGCACC
CGGACGGTGCAGCACCAGGACTCC
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Exon number |
9
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Length |
659 nt
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Location |
Chromosome 16 (NC_000016.9) : -1...-1 ()
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Is part of |
MLST8, mRNA isoform 1
(NM_022372.3)
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Sequence |
Show
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CTTCCTCGGACAACCTGGCCCGGCTCTGGTGTGTGGAGACTGGAGAGATCAAGAGAGAGTATGGCGGCCACCAGAAGGCT
GTTGTCTGCCTGGCCTTCAATGACAGTGTGCTGGGCTAGCCTGTGACCCCTCGGGACTGCCTGGTGCAGGTGGTGGCAGC
TGGAGGGACCCATGCAGCACCCAGGTCAGAGCAGACCCTCCCCTGCCGGCCTGCGCCAGCTGGACCTGATGGCCCCCTGT
GGCGCCTTGACCTGCTGGGCCAGGCTGCCCTGGGACTCTCAGCCCCCAGTTGCTTATCCAGATGTGACAGAGCTCGACCC
AAGCCAGGCTGCACACTCCTGGACTGGGCTAGCCTGCACTGCCTGGGAAAGTCGGCCGAGGGCCCAAAGCTGCTGAGGGG
TCTGAGGCTGGTGCCCACCCCCAAGCTAGTGTGTTCTCTGCCCCTCCCTGCCCGCGTTTCAGGGCCTCGGTCCATAGAGA
ACACCACCACCATGGCCAGGTGGAAGGGTTTATTAGTCCCTGCCAGCAGCTGTCCTCCCTGGTGCAGGTGGCCTGGCCAG
CCCACTGGATTGGGGACGGGCCAGGCTGGGCCAGGTCGGGGGCTCAGTCTGGGAGGTAATAAAAGCAGACCGACACGCAG
ATGTTGCTCGGGAAGCAGA
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Primary source |
Uniprot : Q9BVC4
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Name |
Target of rapamycin complex subunit LST8
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Alternative name(s) |
G protein beta subunit-like Mammalian lethal with SEC13 protein 8
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Synonym(s) |
Gable Protein GbetaL TORC subunit LST8 mLST8
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Organism |
Homo sapiens
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Length |
326 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Function
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Subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Amino-acid-signaling to mTORC1 is mediated by Rag GTPases, which cause amino-acid-induced relocalization of mTOR within the endomembrane system. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with FRAP1 and enhances its kinase activity. In nutrient- poor conditions, stabilizes the FRAP1-RPTOR interaction and favors RPTOR-mediated inhibition of FRAP1 activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum- induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
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Similarity
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Belongs to the WD repeat LST8 family.
Contains 7 WD repeats.
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Subcellular location
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Cytoplasm (By similarity).
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Subunit
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Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains FRAP1, LST8, RPTOR and AKT1S1. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains FRAP1, LST8, PRR5, RICTOR and MAPKAP1. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with FRAP1 and RPTOR. Interacts with RHEB.
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Tissue specificity
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Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
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Biological process
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positive regulation of TOR signaling pathway [GO:0032008]
regulation of actin cytoskeleton organization [GO:0032956]
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Cellular component
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cytosol [GO:0005829]
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Molecular function
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protein binding [GO:0005515]
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Alternative product(s)
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top
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  |
Uniprot Identifier
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Difference(s) with the 'canonical' sequence
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Notes
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Sequences
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Isoform 1
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Q9BVC4-1
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---
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'Canonical' sequence
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Get Fasta
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Isoform 2
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Q9BVC4-3
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1-66 : Missing
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---
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Get Fasta
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Isoform 3
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Q9BVC4-4
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1-1 : M -> MEHAPWSPGASSRARAGHTM
192-198 : GNCYVWN -> APRHLLG
199-326 : Missing
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---
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Get Fasta
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Feature key |
Position
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Length
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Description
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Feature identifier
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Region |
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Repeat region
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1 - 37
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37
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WD 1
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Q9BVC4-REPEAT-WD_1
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Repeat region
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40 - 80
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41
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WD 2
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Q9BVC4-REPEAT-WD_2
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Repeat region
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83 - 122
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40
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WD 3
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Q9BVC4-REPEAT-WD_3
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Repeat region
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126 - 165
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40
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WD 4
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Q9BVC4-REPEAT-WD_4
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Repeat region
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168 - 207
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40
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WD 5
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Q9BVC4-REPEAT-WD_5
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Repeat region
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218 - 257
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40
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WD 6
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Q9BVC4-REPEAT-WD_6
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Repeat region
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268 - 309
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42
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WD 7
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Q9BVC4-REPEAT-WD_7
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Natural variations |
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Alternative sequence
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1 - 66
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66
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Missing
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VSP_032665
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Alternative sequence
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1 - 1
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1
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M -> MEHAPWSPGASSRARAGHTM
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VSP_032666
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Alternative sequence
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192 - 198
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7
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GNCYVWN -> APRHLLG
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VSP_032667
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Alternative sequence
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199 - 326
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128
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Missing
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VSP_032668
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Amino acid modifications |
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Modified residue
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3 - 3
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1
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Phosphothreonine
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Q9BVC4-MOD_RES-3
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Modified residue
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4 - 4
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1
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Phosphoserine
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Q9BVC4-MOD_RES-4
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Modified residue
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7 - 7
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1
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Phosphothreonine
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Q9BVC4-MOD_RES-7
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Experimental info |
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Mutagenesis
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72 - 72
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1
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S->D: Impairs interaction with FRAP1
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Q9BVC4-MUTAGEN-72
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Mutagenesis
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192 - 192
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1
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G->D: Abolishes interaction with FRAP1
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Q9BVC4-MUTAGEN-192
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Mutagenesis
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320 - 320
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1
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F->S: Impairs interaction with FRAP1
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Q9BVC4-MUTAGEN-320
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1 |
MNTSPGTVGS |
DPVILATAGY |
DHTVRFWQAH |
SGICTRTVQH |
QDSQVNALEV |
TPDRSMIAAA |
GYQHIRMYDL |
NSNNPNPIIS |
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81 |
YDGVNKNIAS |
VGFHEDGRWM |
YTGGEDCTAR |
IWDLRSRNLQ |
CQRIFQVNAP |
INCVCLHPNQ |
AELIVGDQSG |
AIHIWDLKTD |
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161 |
HNEQLIPEPE |
VSITSAHIDP |
DASYMAAVNS |
TGNCYVWNLT |
GGIGDEVTQL |
IPKTKIPAHT |
RYALQCRFSP |
DSTLLATCSA |
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241 |
DQTCKIWRTS |
NFSLMTELSI |
KSGNPGESSR |
GWMWGCAFSG |
DSQYIVTASS |
DNLARLWCVE |
TGEIKREYGG |
HQKAVVCLAF |
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321 |
NDSVLG |
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>sp|Q9BVC4|LST8_human Target of rapamycin complex subunit LST8
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIIS
YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD
HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF
NDSVLG
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Primary source |
Uniprot : D3DU88
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Name |
G protein beta subunit-like, isoform CRA_b [submitted name]
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Alternative name(s) |
|
Synonym(s) |
|
Organism |
Homo sapiens
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Length |
326 aa
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Protein existence |
---
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General annotation (Comments)
|
top
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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1 |
MNTSPGTVGS |
DPVILATAGY |
DHTVRFWQAH |
SGICTRTVQH |
QDSQVNALEV |
TPDRSMIAAA |
GYQHIRMYDL |
NSNNPNPIIS |
|
81 |
YDGVNKNIAS |
VGFHEDGRWM |
YTGGEDCTAR |
IWDLRSRNLQ |
CQRIFQVNAP |
INCVCLHPNQ |
AELIVGDQSG |
AIHIWDLKTD |
|
161 |
HNEQLIPEPE |
VSITSAHIDP |
DASYMAAVNS |
TGNCYVWNLT |
GGIGDEVTQL |
IPKTKIPAHT |
RYALQCRFSP |
DSTLLATCSA |
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241 |
DQTCKIWRTS |
NFSLMTELSI |
KSGNPGESSR |
GWMWGCAFSG |
DSQYIVTASS |
DNLARLWCVE |
TGEIKREYGG |
HQKAVVCLAF |
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321 |
NDSVLG |
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>sp|D3DU88|D3DU88_human G protein beta subunit-like, isoform CRA_b [submitted name]
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIIS
YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD
HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF
NDSVLG
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