(BNIP3) BCL2/adenovirus E1B 19kDa interacting protein 3 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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5873
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Official symbol
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BNIP3
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Official name
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BCL2/adenovirus E1B 19kDa interacting protein 3
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 10 (NC_000010.10) : 133781203...133795434 (-)
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Map
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10q26.3
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Length
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14232 nt
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NM_004052.2
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BNIP3, mRNA isoform 1
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Accession
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Name
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Organism
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Length
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Q12983
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BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
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Homo sapiens
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194 aa
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Synonyms |
Nip3
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Alternative name(s) |
bCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B 19kD-interacting protein 3
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Summary |
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl
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1 |
TCCGCTCAGT |
CCGGGAGCGC |
AGCTGGGCCG |
CGGCGCTCCG |
ACCTCCGCTT |
TCCCACCGCC |
CGCAGCTGAA |
GCACATCCCG |
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81 |
CAGCCCGGCG |
CGGACTCCGA |
TCGCCGCAGT |
TGCCCTCTGG |
CGCCATGTCG |
CAGAACGGAG |
CGCCCGGGAT |
GCAGGAGGAG |
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161 |
AGCCTGCAGG |
GTGAGGCGGA |
GGAGGCGGCG |
CGGGAGCCGA |
GGGGGCGCGG |
GGGGGAAGCC |
TGGGGAAGGC |
CAAGAGGGCG |
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241 |
CCAAGGGGAG |
GTTGCCGGGG |
AGGCCTAGGG |
GGCATCGCGG |
GCCGGGCGAG |
GCTGCGCCAT |
CCTCCCCTTC |
CGTACCCACC |
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321 |
CCTCCTGCGG |
GCATGCGGAG |
CCCGGGGCGT |
GGGGACCCCG |
CGTACTGCCC |
GGGGTTCGCG |
GCCTCGCCAC |
TCGGGCGGGG |
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401 |
GTTGGCTTGG |
ACCCGGGTCG |
GACCGCACGG |
GAAAGCCCCG |
ATTCTCCAGC |
TCCGCGCGAG |
CTAGAATTCC |
ACCTGGAGGT |
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481 |
GAATCTGCGT |
CTCGCAGTTG |
GACCGAACAG |
CCTCAAAGTC |
CACGTTGCCC |
TCCGCGGTCT |
GTAGTTCAGA |
CCAGTATTGG |
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561 |
TTTTAATGAC |
CAAACACCAA |
GGCGTGGCAA |
GTGGCCTGTT |
ATGAGCTTTA |
ATTTTGTTAT |
TAATGTTTAT |
ATCCATGGTG |
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641 |
ACTGTTAGGA |
TTTCCTCAAG |
GGTGAACGCG |
GAGATGGGAG |
GGGGTTACAG |
CGTTTTTAAA |
ATATGGCATT |
AAATGGGCAT |
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721 |
GTTCCAATTT |
CACTAGAGGG |
TCGTTCCAAA |
ACAAAGCTTT |
AAATGACTTA |
CGGGTTAAGA |
AAACACAAGC |
AAAAGGACGC |
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801 |
TGCCCGTGCA |
GCACTCAGTC |
GTTACAGCCT |
GCCTAATGCC |
CGAGTAGAGG |
CTCGCTGTGT |
GCCCTTGGCT |
AGATTCGCAA |
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881 |
GACCATCCGT |
TCACGCAGCG |
GGAAACGCAG |
GCCCGGGGTG |
CAGGACTTGC |
CCCACGCACA |
GCCGGGTGGC |
GTGGAGACCC |
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961 |
ACCCCACCCG |
GTGGGTCCGC |
GTCAGAGTCC |
AGACGAGCCT |
TTGCTCAGGG |
AAGCGGGCAC |
TGAAGCCGCC |
TTCCCAGGGT |
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1041 |
CCCTAGGGCC |
AAAGCCTCGG |
AGGAGGGACC |
TGGTGGCAGC |
TGACCTTTGT |
GTTCTTTGAA |
GCCAGAGTTT |
ACTAAGCAAA |
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1121 |
ATTAGCATGT |
AAATAAGCTT |
GGGAAAGGAC |
TGCTGAAACC |
TCTGACAGTG |
AACTTTTAAT |
CTTCATTGAG |
AGTTTTTAAA |
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1201 |
ACCATATATT |
CACATAAATT |
TAGTGAGTTG |
CTAATTTTAT |
TACAAAAAAA |
AAGATTTTAC |
TAGGCAGGAC |
TTAGTTACCG |
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1281 |
TAATATATTG |
AATAATATAT |
ATATATACAT |
ATGAACACTA |
CAAGCTTTTT |
TTTTTTACCT |
TTTTTTTTTT |
TTAAGAGACG |
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1361 |
GGGTCTCACT |
GTGTTGCCCA |
GGCTGGTCTG |
AACTGGGCTC |
AAGCGATCCT |
CCCGCCTCGG |
CCTCCCAAAG |
TGCTGGGATT |
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1441 |
ATAGGCCTGA |
GCCACCAGGC |
GCGCCTGGCC |
TAAAACCATA |
TTCTTTAAAA |
TCCTGTAATT |
CGGATTTTTC |
CTCTTGAAAT |
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1521 |
TTAAACATTG |
GCTAATTACT |
ATTTTGAAAT |
AGATTAAGAG |
GTGTTTTCCT |
ATCTTTTGTC |
ATAAAATAAA |
GTCCAAGGGA |
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1601 |
TGTTTTTATA |
AACTCTTTGC |
CATAAAATCA |
CCCATTTTCC |
GGTTGTGAAG |
CCGCGTTACT |
CCTGACATTG |
TGCGTTTCAC |
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1681 |
TGTCCGGCTG |
GGATCTGGGC |
GCTGGGAGGT |
GGAGGGGGCT |
CCGGGGGGCT |
CGGTCCTCTC |
TCCAATATGT |
AACTTACACA |
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1761 |
GGCTGCTGAG |
TCATTGGCAG |
TGCAAGGCGG |
CCAGCGCCGG |
AGTTACGAGA |
TTTTTGTTTT |
TCTGTTTTGT |
TTATTCTATA |
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1841 |
AAAAGATAGT |
TACCCGCGGG |
GTGGATCCCA |
TGTAGGCGAT |
TCCTTGGGCC |
GCCCTGAGTG |
TCCGCGCGGC |
AGGACGGGGC |
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1921 |
CACTGTGGGC |
TCGGCGTGGG |
CGGGGTTGGC |
CGGTCCCGCG |
GGCTCCAGCT |
GCCTGCAAAT |
CCGGGACGGA |
GCGGTGGCTC |
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2001 |
AGGCAGCGCT |
CACCTCTGCC |
TGTCCGATTT |
CACTGCCCCT |
TGTTGACCTC |
GGAACAGAGA |
ACAATGGGAG |
CCTTGCAGCC |
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2081 |
AGACCCACGG |
ATGGAAGCAG |
CAAGCACTCT |
CTCCTCTGAG |
TGTACCCTCT |
GGGGCCAACT |
GCTTTTCCTA |
AAGAGTTAAT |
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2161 |
GGCAAAATGG |
GCTGATTCTG |
TTCCTTTCTA |
TCTCTTGATC |
ATTCTAGCTA |
AAGTTGTTGA |
CTCGCAGGAT |
GCTCGTATTT |
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2241 |
GTCCTTTTCC |
TTTTTTTTAC |
AAGCCCAGTC |
TTACTCCCCC |
AGGCTGGAGT |
GCAGTAGCAC |
AATCATTATA |
GCTCACTGTA |
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2321 |
GCCATGAACT |
TGGCCCTTTT |
CTCCTAGACA |
TGTCACTGCT |
AACATGCAGG |
AGAGGTAGGA |
TTCTGTGACG |
AGACCGTGTC |
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2401 |
ACGGTGGCGG |
GGGCATCACT |
TCCTTGAAGG |
ACCCACTGTC |
TTCACCAGGA |
GGGCATCAGT |
TCAGTAAAGT |
GCATGCCCAT |
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2481 |
TTACTCTGGA |
GGGCCGTGTT |
TAATAATCCA |
AGCCCTCACC |
TCTTCACCCA |
CTGCTGTGTC |
TGCAACTGGC |
AGATGGTTCT |
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2561 |
CTCTCTTGTC |
AGAGGCAACT |
CACCATGGGC |
AAAGTTGTAT |
GAGGGGAAAA |
GATGTTTTCT |
ACTTATTTTG |
GAGTGGAGTT |
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2641 |
GTAGCATTGT |
GTGCTTTGAG |
ACCTGAAGGG |
GTTGCAGACA |
TCGAGATTCT |
CGTCCAAGAC |
TTGCATTTCA |
TAGATGGTCA |
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2721 |
CAATGAGGTT |
CTAGAGGTGG |
AGTGAAAGAT |
AAGGCTGGCA |
ACAACACTTA |
AGGAGAAGCC |
AAGGTCTCTG |
CATGAGGCAG |
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2801 |
CAGTGGGATA |
CCTGGAGCCC |
AGATGCCTGA |
GGCTGCGTGC |
AATAGGCCCT |
GGAGGGTCCT |
GGAGGAGAGG |
AGGCCAGAGG |
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2881 |
TCCTGGAGGC |
AACAGGAAGG |
TGGAGGGAAA |
CGAGCCCCGT |
TGGAAGCCAG |
GGACCTGATT |
TACCTACCCA |
GCTGACTTGA |
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2961 |
TACTTGAAAT |
CTTTTGTCAG |
GCGGGTCTCT |
TTTGTTCTCT |
CCCCACTAAC |
CTGAGAAGCT |
TTAAAGGTAA |
AACAGCAATT |
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3041 |
TCTTAGAGCC |
CACCTCCCCT |
GGGGAAGAAG |
CCCTTTGTAT |
GGTTTTGGGG |
TGCTAGTTCC |
CTCGGGGGTT |
CACAGCTCCT |
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3121 |
CTGCTTCAGG |
TTTTTTTTCT |
GGGATGCTGC |
CTCCCTCTGT |
TCTGACATTT |
ATCCCAGAGC |
TTTTTCAATC |
TATTTGCCTG |
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3201 |
GATTCCACCC |
CAGCATCCCA |
AATAGTCACT |
TTCAGAGTGG |
GCTGAGGCTA |
GGCTTTTGGA |
GAACAATGAA |
AAAACACCAC |
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3281 |
AGGTGATTCT |
CCCTTCATAG |
CCAGAGTTGA |
GGTTGTCACC |
CCAGGTTAGG |
GCATAGGGTG |
GCCTTGAGAA |
CTTGGCCCTG |
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3361 |
TGTTTACTCC |
ACGTGGGGCT |
CGTGGCTGTG |
GCCCATGAAT |
CCATGTTGAG |
GAATGGGACC |
CAGGGAGTTG |
CCCTGGGACA |
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3441 |
TACAGAGGGC |
AGTGAATCGA |
AGGGATTCCC |
TGGAGTCTGT |
CACTGGAGGG |
AGAACTGCTT |
TGGGCACCTA |
GAAAAGCTGG |
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3521 |
ATGTCAGATG |
ATTTTTTTTT |
TTTTTTTTTA |
CACAAAGTGA |
GAATAAGAAA |
TGGATTAAGA |
ACTCTTGTTG |
GACTGTATTT |
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3601 |
TGTCTCTGAG |
GCAGACCTAT |
CAGTTTTCTT |
TTTGTACTGT |
GATATAAATA |
TTTATAGTCT |
AGGCTTTTCA |
AAATCTCATC |
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3681 |
TACCTTGATA |
TAGGAGGGAG |
GTAAGATTTA |
CTGGCTGTGT |
GTCTTGTTAG |
CAATGTAAAT |
TATAAGTGAG |
TGAGGAGGGG |
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3761 |
GAGGAACATG |
AGAGGGACGC |
GAAATGAGAT |
TAGGAAGGAG |
GGCTTTTCTT |
GCAGCAGCAA |
CAGCAGCACC |
TTTCCGTCTG |
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3841 |
GGGCCTAATT |
ATACTACAGT |
GATTTGAAGT |
GTAAACTGCT |
TGTGATTATG |
AGCAAGTTTT |
CTAAGGTTAT |
TAAGCAACCT |
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3921 |
TACTGTAAGC |
CCATCTTTCT |
TTGAAAAGGT |
GAACGATCCG |
AGTGGAGAAC |
TGTAACACGT |
GAGTAGATAC |
ACAGCACGCT |
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4001 |
CCATTCTCCA |
GGAAGTGCCT |
TCCTTTCCTA |
CGCGGTTGCT |
GTGGGTTAAT |
AATAAAACTC |
CTGTCCCTTA |
GTAAATCATT |
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4081 |
CCTGGGAATA |
CAGCTTTTGG |
GCCCAAAGTC |
ATTAGCCATG |
GACAATCTGG |
AGTGAGTTTT |
TTTTCCTTGT |
TTCCTGGATT |
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4161 |
TTTAGGTCCT |
TTCTGGGGTG |
ATGTTTAAAA |
AGCACTGCTT |
TGGTTCGAAT |
GTGTTCCTCC |
ATGTTGCCAG |
TGGGATGGTA |
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4241 |
GTAAAAGGTG |
GGCCTTTAAG |
AGGTGGCTCG |
GCCATAGGGG |
CTCCTCTCTA |
GTGAATGGGA |
TTAGTGCTCT |
AAGGGGCTGG |
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4321 |
ATGGAGGGAG |
GTGGGTCCCT |
CTGTAGCCTC |
ATTGAAGGGA |
TGAGGCAGGA |
AGGCCCTCAG |
CCGACACCAG |
ATGTTGGTGC |
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4401 |
GTGGATCTTG |
GACTTCCCAG |
CCTCCAGAAC |
AGAGATCAGT |
TTCTGTTCGT |
AAATCACTAA |
GTCTGTGGGA |
TTCTGTTGCA |
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4481 |
GTAGCGCAGA |
GGATGACAGA |
GATACACTTG |
TCTCTCCTTC |
ATCTTCCTCT |
CCCTGTTGTC |
TTCAGCCTGC |
CCCTTGTGTG |
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4561 |
ATAGATTACA |
GTATGTGTTT |
GGTCTTGACC |
CTACCTACTT |
CCTGGTGCAG |
AGCACCTAAA |
CCCCTGGGGC |
TTCCTGAGCA |
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4641 |
GTGTCTTTTT |
TTTTTGTTTG |
AGACACAGAG |
TTTCGCTATT |
GTTGCCCAGG |
CTGGGGGGCA |
GTGGCATGAT |
CTCGGCTCAC |
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4721 |
TGCAACCTCC |
CCCTCTCAGG |
TTCAAGGGAT |
TCTTCTGCCT |
CAGCTTCCCG |
AGTAGCTGGG |
ATTACAGGCG |
CCCACCACGC |
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4801 |
CCAGCTAATT |
TTGTATTTTT |
AGTAGAGACG |
GGGTTTCACC |
ATGTTGGTCA |
GGCTGGTCTC |
TGACTCCTGA |
CCTCAGATGA |
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4881 |
TCTGCCCGCC |
TCGGCCTCCC |
AAAGTGCTGG |
GATTACAGGC |
ATGAACCGCT |
GTGCCAATAA |
GTGTCTTAAG |
CATGTTTATT |
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4961 |
AAAGAAAGTA |
AAACAGTAAA |
AAGATGGTGA |
CTCCATAGGC |
AGAACAACCT |
GACCAGTGTG |
TGCGTTATTC |
ATAAAGTCAC |
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5041 |
CCTATTAGCA |
GTGTACTCCA |
AAAGTGCTCC |
TTGGTTAACC |
ATTTTTGGTG |
TAAGTTGTAA |
GGAGCCCCTT |
CAGAATACAC |
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5121 |
TGCTAATACA |
GTGGCTCAAG |
GGTGGCCCCA |
GGATAGTTAC |
TTGAGGTAGA |
AATTCCCAGG |
GCAGCCCCTC |
CTAGGAGGGG |
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5201 |
AGGGGACTGG |
AGATGGAGAT |
GGGGGAGCCA |
TGAGGTGCGG |
GTAGCATGGT |
TGGGGTTAGG |
GTTGGGACAT |
GTGGGGTAAG |
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5281 |
TGGGAGTCTG |
GTTGCAGAGA |
GTGTGGTTGG |
GGTTAGGGTT |
GGGACGTGTG |
GGGTAGGTGG |
GGATCTGGGC |
TGTATGTCAT |
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5361 |
TTCCATTTGT |
CTGCCCTGGA |
ATTGTTTCTG |
GTAAACTGAT |
AAATGTAAGT |
AAAGAGTTTT |
TCTGAGTTCT |
GTGAATTGTA |
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5441 |
GTAAATTACT |
GAACCTGAGG |
CAGGTGTGTG |
GGATCCCCTG |
AGTAGGTAGA |
GGCACTGGCA |
GAAATACGGG |
TAACCTGGAC |
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5521 |
ACCCCATTCT |
CTGCTTGCAT |
CTGTGGGAAC |
AGTCTTGTGG |
GCTCCACACT |
AAGTCTAGGT |
AGATAGAATG |
GAATTGAATC |
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5601 |
GTTGGACACC |
CCGGTGGTGG |
TGACTTGGTG |
TCCCACATTT |
GATGTTAAGA |
GTGGCATCAG |
AGAAGAGACA |
CCACACCTTC |
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5681 |
AAGTTGCATT |
TGTGTTCCAT |
ATCGTCAGAT |
AGCTGAACAA |
CACTTTAGTC |
AAGTAAATTG |
AAGCAGGCCC |
AGAATCTGAA |
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5761 |
TACTGTAGAT |
TCAGCGGAGA |
AAGACAGCTG |
GCCAAAACAG |
AGGCTGTGGT |
GCCGTTCTCT |
CAGGGGCAGG |
CCATGGCTAG |
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5841 |
CCGGCCGCAT |
GGCATCTTGA |
ACCGCAGAGA |
GGGAAGGAGG |
GCTAGTGAAC |
ATCAGAGTAC |
TTGGCAATAC |
TGTCTGGTCA |
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5921 |
GATGAGCGGC |
TTCAGGAATG |
GTGTGGTCTG |
TACATCTCAG |
AAGGCACCAT |
GTAGCCTCTG |
CCAGAGTGTG |
GGGCAGACTG |
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6001 |
GCCTGGGCCT |
TTCTCCTCCA |
TTGAGCTCCA |
GGCTCCGAGA |
CAGACCCTGG |
CTTGCCTTTG |
TATTAGGGAT |
GTGCTTCGTG |
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6081 |
TAGGCCAGGA |
CATGAGGCAA |
CGTGAGAGGC |
CAAAGAGAAC |
AATCATGCGT |
TCATTTGAAA |
ATTTGTGTGA |
TCATTTCGTT |
|
6161 |
AGCAGCTTAC |
TGGGAGACTG |
TTGATGGCAT |
AAGTTGCAAA |
TCCACTTTTC |
CTTCCTGGGC |
CTTCGGTTTG |
CTTTTTTCTG |
|
6241 |
GTTAATATGA |
AATAGACTCT |
GCAACAAGTG |
GCGTATGGAG |
CCTAGGCCAG |
CCCTCTTTCA |
GGAGAGATGC |
CTCGTGTGTG |
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6321 |
TGGAAAGCTG |
TGCACCTGCC |
TTTGCTTCCA |
GCGAACATGA |
CGGATGAAGA |
GGCTGCTCCT |
TTCCCCCTAA |
TTGCATGGTG |
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6401 |
TTATTAGTGC |
TGTGTTGGTT |
TAAGGACAGT |
CAGCAGCTCA |
GGGTGATTAT |
TCTGCTTACT |
AAAATTATAG |
TGACTGCAAA |
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6481 |
AATGAGATAA |
TTCCATTGTT |
CTCGTCCATA |
AGTTTCCCTG |
TCTTTTGTGG |
CCTGCACTTT |
CCTCCCACTG |
CACTCCATCC |
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6561 |
TCCATACGCT |
ACCAGAGGAA |
GCTCCTACCA |
GATTTGCTTT |
AAATAAATAA |
ACCTATGACA |
CAAAGTAGAG |
AGATTATCTG |
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6641 |
GGGCCCAGAA |
ATAGACGTGT |
GCCTATATGC |
ACGCTTGATT |
TCTGACACAG |
GAAGCAGCCA |
GCGCAGAGTG |
AGGCGGGAGC |
|
6721 |
TGTCTGCAGT |
AAATGGGGCA |
TCCGTCTCAC |
ATCAATGGGA |
AAATTAATCC |
ATGTAGATTT |
TGGATCTAAA |
TGTGACTGTC |
|
6801 |
ATAACAGTAG |
AGCTGTGTGA |
AAATAATAGA |
ATAGAATATC |
TCAGCTCAGG |
AAGGGATTGC |
TGCATTTGAC |
TGAATTAAAA |
|
6881 |
TCAAGAACTT |
CTGTACATCA |
GAAGACATCA |
GAAGTGAAAA |
GAACAAGCTA |
CCGAGGGAAA |
GTTACTTGCA |
ACATATTTAA |
|
6961 |
ATGCAGAAAA |
ACATATATCT |
AGAATACAGA |
ATTATCCCAG |
AATTGCACTT |
TTAGCAGTAA |
GGGAACGGGA |
GCAGCGTTCC |
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7041 |
AGCCTCAGTT |
TCTATTTATA |
ATGGTGACAT |
GGAAAAAATA |
CTGCTGGATG |
CCCACAAATA |
AGAGAAAGAC |
AGATAATAGA |
|
7121 |
AAAGAATAAG |
AGATTCGAAG |
AACCAGTTCA |
AAAAAGATGC |
TATCCAGATG |
GCTAGCAAAC |
TTGTAAAACC |
GTCTTCAACC |
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7201 |
TCGTTAGAAA |
TTATATAAAT |
GCAAAGTAAG |
CCACACGATG |
CAAGTCATAG |
AGGCTGGGCA |
TGGTGGCTCA |
CGCCTGTAAT |
|
7281 |
CCCAGCACAC |
TGGGAAGCTG |
AGGTGAGAGG |
ACTGCTTGGG |
CCCAGAAGTT |
CGAGACTAGC |
CTGGGCAATA |
TAGCGAGACC |
|
7361 |
CCATCTCCTA |
AAAAAAATAG |
CCAGGAGTAG |
TGGTGCATGC |
CTGTAGTTCC |
AGTTATTCCG |
GAGGTGTCAG |
CTAGAGGATG |
|
7441 |
GCCTGAACCC |
AGGAGTTTGA |
GATTATAGTG |
AGCCTTCATC |
GTGCCACTGC |
ACCCCAGCCT |
GGGTGACAAA |
GCGAGACTCC |
|
7521 |
GTCTCGAAAA |
GAAACAAAAA |
ATAGAGCTTA |
AACCTTTTAA |
AGAAAACTTC |
AAATCCCTTA |
AGCTTATGTT |
GACATTAGTG |
|
7601 |
TTGTTGTTGT |
TTTTTTTAAA |
GACCTCTTTT |
TCCAAATAAT |
AGCCTTTTTC |
TTATAAAAGC |
TCACTGCAAG |
GAAGTATTCT |
|
7681 |
AATTGGATTC |
TGTTGACTCA |
GCAGAGTTAT |
TGGACATTGG |
CTTGGTATAA |
AGGGACTGCA |
AGAGCTGGAC |
AGATACATGG |
|
7761 |
TCTCAGCCCC |
AGGGGGCTTC |
CTTCCTGTAC |
CCAGGGAGTG |
TGTGCGTGGA |
CAGTCACTGC |
CATGAGAGTG |
GGCAGAGGGA |
|
7841 |
TGTCTTCAAG |
TCGGGGTTGA |
GGGATGGTTC |
CTGGTGTGGC |
ACCATTGCTA |
CCTCTTGGAA |
ATGGAAGGGC |
AGGCTGGTTA |
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7921 |
GATATCAAGA |
GCAGATTCCA |
GAGTGGGTAG |
AGAATTCCAT |
CTGCGCCCCT |
TTTTTTGTCC |
CCATCAGGCT |
CCTGGGTAGA |
|
8001 |
ACTGCACTTC |
AGCAATAATG |
GGAACGGGGG |
CAGCGTTCCA |
GCCTCGGTTT |
CTATTTATAA |
TGGAGACATG |
GAAAAAATAC |
|
8081 |
TGCTGGACGC |
ACAGCATGAG |
TCTGGACGGA |
GTAGCTCCAA |
GAGCTCTCAC |
TGTGACAGGT |
AGGCGCGCAT |
CAACAAGTGT |
|
8161 |
ATGTGTTACA |
GTGCCGATGT |
CTTCAGTGGG |
TGACAGTCAC |
AGCTGGAAGT |
GCCCGTGTCA |
CCTCTAGGAC |
AGTGGGCTGC |
|
8241 |
TGTTCGCCTC |
GGGCCGCGTT |
CTGGACTGGC |
TCCTGCTGCA |
GTCCGTCCTT |
ATATAGGAGC |
CTCGCCCTCT |
TTGGGGATGC |
|
8321 |
AGTGACCTGG |
GACTTAGTCT |
GTGGGGAGCC |
ATGTTCAAGT |
CATCAGTAGG |
CAGCGGAACA |
GCCACAAACC |
CCACTCTGAG |
|
8401 |
AAACGCACTC |
ACGCGCCTCA |
GCGGGGCTGT |
GGTCGCAGGA |
GGAGCGGTCC |
CTGGTTAGCA |
GTACTTCTGA |
GTGACTCCAA |
|
8481 |
GGTAGAGTGG |
CCGACAGTGG |
TCAAAGGTCG |
CGTGCCCTTG |
AGAGCTGTGC |
AACAGACCCA |
GACCGTGAAG |
GCGGCAGGTG |
|
8561 |
ACAAAGCCAG |
CTGCTTGCCA |
GTTGCCCCTG |
CGTCTTCTCT |
GGAAGACTGG |
CTAGCTCACT |
CCTGTCGTGC |
TCAGCCAAAA |
|
8641 |
GGGCTGAGGA |
AGAGTTTGGC |
TCTGGCAGGT |
GCTGGGTGGA |
AGGGAAGACG |
CGTACGCTGA |
CTGGCTAGAG |
CCCCTCATCA |
|
8721 |
CGGAGGCGGT |
TCACTGCCTT |
TGGGGTTTGA |
GCTTCTAATG |
ATAGAATGTT |
CACATGATGT |
TCTGTTTTTC |
CCATTCTATT |
|
8801 |
CACATCGCCA |
AGCCCACCTC |
GCTCGCAGAC |
ACCACAAGAT |
ACCAACAGAG |
CTTCTGAAAC |
AGATACCCAT |
AGCATTGGAG |
|
8881 |
AGAAAAACAG |
CTCACAGGTA |
AGCTGGAAGG |
AGAATGTGCA |
GTTGTAAAAG |
TATTTGTGAT |
CTGTTTGTAC |
AGGAAACGGT |
|
8961 |
TTTAAATGTA |
ATTGAGCACC |
TCAGAGAAAA |
GTCGGGCTTT |
AAGGGTGTTT |
CCTGCTTTAA |
AAAAAACAAA |
AAAGCGAAAC |
|
9041 |
AAAAAAACCA |
AGAAACTGTG |
GGTGGGAACA |
TCCACAAGCA |
CATGGGCTGG |
ACACTCAGCT |
GAGCGGGGGA |
GGCGCCGAGT |
|
9121 |
GGGACAGGCA |
GCGGGGGCCT |
CCTGTCCCTC |
CCTGCCTGCC |
ATCAGGGATA |
CACCGGAAAG |
GAGGAAGGGC |
TCCCTGGTGG |
|
9201 |
CTGCAGCCTA |
GAGAGGAGGG |
AGGGACCATT |
GGAAGGGGTG |
GCAGTGAGCC |
AGCTACTGGC |
TGGTCTTTCC |
TCGTGGTTGC |
|
9281 |
TGGTTGGACA |
GTGAGTGGGT |
TTTAATATTT |
GCATGCTGTG |
TGGGACTCAG |
GAGTTACCCA |
CGGGGCCATC |
TAAGGCCATG |
|
9361 |
TGGCCACTGT |
GGCTGTGACT |
CTGAGGTGTC |
TTCCTCATTA |
GACACTCACT |
ACCTGCCGGA |
AATTACACCC |
TGTGCCTTTC |
|
9441 |
CTAGCATTAG |
TCCTGAGCTA |
ACTGGTGCCG |
GAGCAGTGTA |
GCATTAGCGG |
CTGATCAGCC |
TGATAATTTA |
GTGTAAGATC |
|
9521 |
ACTTTTTCTT |
CTTTTTTAAA |
AAAGTTTTTT |
TTGTAGAGAC |
GGGGTCTCCC |
TGTGTTGCCC |
AGGGTGGTCT |
TGAACTCCAG |
|
9601 |
GGCTCAAGTG |
ATCCTCCCAA |
AATACTGGGA |
CTATAGGTGT |
GAGATACTGT |
GTCCAGCCTA |
AGATGACTTT |
TCTGTTAACA |
|
9681 |
GCTATTGAAT |
GGGCTTTACA |
GAGCGGCCTT |
CAGCATTGTT |
GTGAAAGCGG |
AGTGAGTCTT |
AGAGGAAAAA |
GTGTACCTGG |
|
9761 |
GGTTATTGCC |
TTGGTGTACT |
ATCGTTCTCC |
CTTCCTACTC |
CGGCACAGAT |
AGGGTTCGAG |
GCAGTGATCA |
GTACTGTCTT |
|
9841 |
GCTCAGTTAT |
ATCTGGCAGT |
GCCTTACCTT |
GCTGCAGATG |
AGATGCGCGA |
TGTGTTTTCT |
TGGGTGTTCG |
TTGCTGGTGA |
|
9921 |
GAACTTTGAC |
GACGGACTGT |
GTTCTGTATT |
TTGGAAGCTC |
TGTGAGGAAG |
CATGGCCTTC |
CAGGCAGGGT |
TAGTAGCTGA |
|
10001 |
CCCTTCCGTG |
CTAGCGCTTC |
CCTCAAGGCT |
TTCTTCACCA |
AGGAAACAAG |
GAGTCCCTGT |
TACCCAGGCT |
TTCTCAGGGA |
|
10081 |
CATCCCCTGG |
CCCCACTCCG |
AGGGGCAGCA |
TGATTTCGGG |
AGCCCCAGGA |
GCCCTGGCTG |
TGGGTGTGTG |
GGTGCATCCA |
|
10161 |
GGGCGTGCGG |
CCTGCTCCTG |
GGCACTTGGG |
GCTGTACCCA |
GCTTGGGTGT |
ACCCAGATGT |
TTGGTGGGTT |
TGGGGAGCTA |
|
10241 |
TATTCTTGAG |
TATTTTCAAT |
TTTATTTCTT |
TTTTTTTGAG |
ACAGGGTCTT |
GCCGTTTTCA |
CTGTTTTACA |
CAAAACTTCC |
|
10321 |
CCTAGTTTTA |
AAAGGAATTA |
GATGTTCAGG |
TACAGAATTT |
TGAAAATGCA |
AAAAAGTAGA |
GAAAAACACT |
TAGACTCTCA |
|
10401 |
GATTTAAAAT |
CCTCTTTAAT |
GTTTCGTGCT |
GTTATATAAT |
TCTGAGGATT |
TGGCCGCAGC |
TGTGGTTATG |
TGGACATTTC |
|
10481 |
TGCCTTTTCC |
CTCCTGCTTA |
TCCCGGAAGC |
ATCTTGTAAA |
CCTGCTCACT |
ATACAGTGTC |
CCTTCCTTCG |
TCATGTCCCT |
|
10561 |
GTTTTGAGCC |
GTTTTCGGCT |
GTTTTCATTT |
TCTTTTCTTA |
TAACCAGTGC |
TGCCGTCACC |
ATCTTTGCCC |
TCATGTCACG |
|
10641 |
TGACTTCCCT |
AGGACAGTGT |
TTGCCGCTGT |
CAGTACCCCC |
AGAATCTCAC |
AGTGAACCAA |
ATGTATTTAC |
GCCCTGAGTG |
|
10721 |
GGGCTCCCCC |
AGAGGTGATC |
TGTCCCTGGA |
GGCGGCGAGC |
GTGCTGTGAG |
CCGGGAGTGC |
GGCGCGGCCC |
GGGGAAGGCC |
|
10801 |
CCCAGCCCCA |
GGACTCCCCT |
TGGACCACGG |
TCCGAGGCAC |
TGACATGTGC |
CTCTGGGCTC |
TTGAATTGAG |
CCTGCGGATC |
|
10881 |
TGAAGCTCGG |
GTGGGAGCTG |
GGTGCTTTCC |
CGTGTCACGT |
GTGGTACACT |
GATCTGCCTT |
TAACATTGAC |
TTTATCTTAG |
|
10961 |
TCTGAGGAAG |
ATGATATTGA |
AAGAAGGAAA |
GAAGTTGAAA |
GCATCTTGAA |
GAAAAACTCA |
GATTGGATAT |
GGGATTGGTC |
|
11041 |
AAGTCGGCCG |
GAAAATATTC |
CCCCCAAGTG |
AGTGTGTTCT |
CAGTGTCACG |
GGGGCACCCC |
TTGACAGAGG |
ACACATCAGC |
|
11121 |
TGACACGTTT |
CTTCCCGCCT |
CAGGGAGTTC |
CTCTTTAAAC |
ACCCGAAGCG |
CACGGCCACC |
CTCAGCATGA |
GGAACACGAG |
|
11201 |
CGTCATGAAG |
AAAGGGGGCA |
TATTCTCTGC |
AGAATTTCTG |
AAAGTTTTCC |
TTCCATCTCT |
GCTGCTCTCT |
CATTTGCTGG |
|
11281 |
CCATCGGATT |
GGGGTAGGTG |
ATGTGACTGT |
GTGACTCCTG |
TCATGGCATG |
TCGTGGGGCG |
ATTCTGGGTT |
GCAGTGATTT |
|
11361 |
ATTCGTAACC |
TGTTTCCTGA |
AGTCCAGATC |
ATCAGTTACA |
GCTTGGTGCA |
TTTTCACAAA |
CACCCACGTA |
GTCACTGTTC |
|
11441 |
AGGTCCAGAA |
ACCACCAGCC |
TGCAGCCCCC |
AAAGGCCCCA |
GCACAGGCGC |
CCTGTGGTGC |
TGCTGTCTGG |
CCTGACGAGT |
|
11521 |
CTGCCTGTTG |
CTCACTGAAT |
ATAAACGGAG |
TCAAAGCAGG |
GCTTCTTAGG |
TCTGACCTCT |
TTGTCCTGTG |
TGTAGGTGAA |
|
11601 |
AGCAGTCTCA |
TTTCTGTGTA |
GTACTGTGGC |
GGGAATGCAC |
CCAGCTCTGC |
TGTAGGTGGA |
GGGTCTCAGT |
TACCTGCTGT |
|
11681 |
ACTTCCTCCA |
GACAGGACTG |
TTGTTCTAGT |
AACTCTCAGC |
AATGAAGGAA |
CCAATGCAGT |
CTCCGACTTT |
ACTGGCTTGA |
|
11761 |
GTTTCGCTCT |
TGTTGCCCAG |
GCTGAGTGCA |
GGGGCGTGAT |
CTCGGCTCAC |
TGCAGCCTCT |
GCCTCCTGGG |
TTCAAGCGAC |
|
11841 |
TCTCCTGCCT |
CAGCCTCCTG |
GGTAGCTGGG |
ATTACAGGTG |
CCCACCACCA |
GGCCTGGCTA |
ATTTTTGTAT |
TTTTAATAGA |
|
11921 |
GACGGGGCTT |
CGCCACGTTG |
CCCAGGCTGA |
TCTCGAACTC |
AAGGGATGGC |
TCACCTCGGC |
CTCCAAAGTG |
CTGGGATTAC |
|
12001 |
AGGCGTGAGC |
CACCGCGCCT |
GGCCTTTCCT |
GGCTGCTTAT |
ACTCACTCAC |
CCTGCAGAAA |
ACACAGAGAC |
CAGGCAGGCG |
|
12081 |
CCGCTGTGGG |
TTCTGAAGAG |
CGTTCGCCGC |
AGCGGTGGTG |
AAGAGCCAGA |
GCGGGAAGCC |
AAAACGGCTC |
CTCCTCGGGC |
|
12161 |
TGGTCCCAGC |
CTCTCAGCGG |
GGAGGAGGGC |
TCTAGTCCTG |
GCGTGCAGAC |
AGTGTTCTGT |
GGCTGCCGTG |
TGTTGGACAG |
|
12241 |
ACTGGAAAGA |
CCGGAATGCC |
ACTGGGGGCA |
GGTGGGTTAG |
GTAGGTTGGC |
CAGAGGGCTC |
ACATCTGGGG |
TTGAAGGAAA |
|
12321 |
CGGGATAAAA |
GCCACTGAGT |
TTCCTGGGCC |
GGGACCTGAG |
CGCTGCCCGT |
GTCTCCACCT |
CGCCCTCCCG |
TGTGCGTGGC |
|
12401 |
TTTCTCCTAG |
CTCTTGGGCA |
CATTCTCACG |
TCCCCCCCAT |
AACCCGTCAC |
CTTCATTTCT |
GCTGGTGCTT |
TTGGGAGTCA |
|
12481 |
GACCTACAGA |
CTGCATCAGC |
ATCACCAGGC |
AGTTTGCTTT |
CTGGAGCCTT |
TTCCAGAACT |
GTCAAGCAGA |
CTCTGGGGGC |
|
12561 |
AAGGCCTCGG |
GATCCTCATT |
TTAAATACAA |
GGTTTAAGCC |
CTTCGTTTCA |
GGATGGATTT |
CTGCAGCCAC |
TACTTCCCAG |
|
12641 |
CTACTGTCCT |
TCGTCCTGCC |
CGGGTTTTCA |
GAGCCTGATG |
CTGCCACTGG |
CGACCCACAC |
CCCCTCAGCT |
GCTTTTCAGA |
|
12721 |
ACCACACGAT |
AAAATCTGCC |
CCGAAAGCTG |
CTGCAGCACT |
GTCTGCGCTC |
ACAGTGCCCA |
CCACACCACC |
GCCCACAGGC |
|
12801 |
CAGGCCAGCC |
AGGCTTCCGA |
TTCTGCCCTT |
TCCTGGAGAC |
CCATCCTCCT |
CCCTCCGGGA |
GTGATGCCCG |
CTGGTCAGCT |
|
12881 |
GGAGCGAGCC |
TCTCTATTGC |
CGAAAAGCCT |
TTTCTGACAC |
TCCTGCATCT |
TTAGTTTGGG |
ACATCTCTCC |
CACTACCAAA |
|
12961 |
CTTAAACCAC |
ATGAGGGCAG |
GGGCTTCATT |
TTTAAGCAGT |
TGGCTTTGGT |
GAGGCTGGTG |
GTGATGAACT |
AGCAACACCA |
|
13041 |
TCTTGCCCTG |
GTAGGTGACT |
TCCCCCAGCA |
CTGAGTTGGA |
ACAAAGCAGA |
AGCTTTCTGT |
GTGGAAACAG |
CATTCGGTTT |
|
13121 |
GGTGATCCTT |
CTATGTAAGA |
ATACGATCTG |
ATGTTTTCTA |
AGTTAATTAA |
TACAAAATAC |
ATATTGATAA |
AACACTAGAT |
|
13201 |
AAAAGATCAC |
AGATAGATTC |
ATTACAAAAT |
TTTTATAATG |
GGTATAAAAT |
CACCAGTCCC |
CTTGCATAAG |
CTCTAACCAC |
|
13281 |
AGTGAGCTAC |
CCTGTTTCAG |
CTGTAACACA |
GTCTCCTGTG |
AATCACAAGA |
TACATTAACT |
ACTGATAATT |
TTTCTGTGAA |
|
13361 |
GGATCTATAT |
TGGAAGGCGT |
CTGACAACCT |
CCACCAGCAC |
CTTTTGATGA |
AGAACTGGAG |
TCTGACTTGG |
TTCGTTAGTG |
|
13441 |
GATTACTTCT |
GAGCTTGCAA |
CATAGCTCAC |
TGAAGAGCTG |
TTAGATCCTG |
GGGTGGCCAC |
GTCACTTGTG |
TTTATTTGTT |
|
13521 |
CTGTAAATGC |
TGCGTTCCTA |
ATTTAGTAAA |
ATAAAAGAAT |
AGACACTAAA |
ATCATGTTGA |
TCTATAATTA |
CACCTATGGG |
|
13601 |
ATCAATAAGC |
ATGTCAGACT |
GATTAATGTC |
TACTGTGAAA |
ATTTGGTAGT |
AAATTTTCAT |
TTGATATTAG |
ATATAAATAT |
|
13681 |
CTGAATATAA |
ATAATTTTAA |
TATACTAGTC |
ATGATGTGTG |
TTGTATTTTA |
AAAATTATCT |
GCAACCTTAA |
TTCAGCTGAA |
|
13761 |
GTACTTTATA |
TTTCAAAAGA |
ATGAATAACA |
TTGATAATAA |
AATCGCTACT |
TTAAGGGGTT |
TGTCCAAAAT |
AAATATTGTG |
|
13841 |
GCCTTATATA |
TCACACTATT |
GTAGAAAGTA |
TTATTTAATT |
TAAATGGATG |
CAGGTTGTCT |
ACTAAAGAAA |
GATTATATAT |
|
13921 |
AACTATGCTA |
ATTGTTCATA |
ATCAACAGAA |
ACCAAGATAG |
AGCTACAAAC |
TCAGCTGTAC |
AGTTCGTACA |
CTAAACTCTT |
|
14001 |
CTTGCTTTTG |
CATTATAAGG |
AATTAAGTCT |
CCGATTATTA |
GGTGATCACC |
CTGGATGATC |
AGTTTTCTGC |
TGAAGGCACC |
|
14081 |
TACTCAGTAT |
CTTTTCCTCT |
TTATCACTCT |
GCATTGGTGA |
ATTTAATCCT |
CTCCTTTGTG |
TTCAACTTTT |
GTGTGCTTTT |
|
14161 |
AAAATCAGCT |
TTATTCTAAG |
CAAATCTGTG |
TCTACTTTAA |
AAAACTGGAA |
ATGGAAAAAA |
AAATAAATCT |
TT |
|
|
|
|
|
|
|
|
|
|
|
|
>ref|Gene_ID:664|BNIP3|NC_000010.10:133781203...133795434 (-)
TCCGCTCAGTCCGGGAGCGCAGCTGGGCCGCGGCGCTCCGACCTCCGCTTTCCCACCGCCCGCAGCTGAAGCACATCCCG
CAGCCCGGCGCGGACTCCGATCGCCGCAGTTGCCCTCTGGCGCCATGTCGCAGAACGGAGCGCCCGGGATGCAGGAGGAG
AGCCTGCAGGGTGAGGCGGAGGAGGCGGCGCGGGAGCCGAGGGGGCGCGGGGGGGAAGCCTGGGGAAGGCCAAGAGGGCG
CCAAGGGGAGGTTGCCGGGGAGGCCTAGGGGGCATCGCGGGCCGGGCGAGGCTGCGCCATCCTCCCCTTCCGTACCCACC
CCTCCTGCGGGCATGCGGAGCCCGGGGCGTGGGGACCCCGCGTACTGCCCGGGGTTCGCGGCCTCGCCACTCGGGCGGGG
GTTGGCTTGGACCCGGGTCGGACCGCACGGGAAAGCCCCGATTCTCCAGCTCCGCGCGAGCTAGAATTCCACCTGGAGGT
GAATCTGCGTCTCGCAGTTGGACCGAACAGCCTCAAAGTCCACGTTGCCCTCCGCGGTCTGTAGTTCAGACCAGTATTGG
TTTTAATGACCAAACACCAAGGCGTGGCAAGTGGCCTGTTATGAGCTTTAATTTTGTTATTAATGTTTATATCCATGGTG
ACTGTTAGGATTTCCTCAAGGGTGAACGCGGAGATGGGAGGGGGTTACAGCGTTTTTAAAATATGGCATTAAATGGGCAT
GTTCCAATTTCACTAGAGGGTCGTTCCAAAACAAAGCTTTAAATGACTTACGGGTTAAGAAAACACAAGCAAAAGGACGC
TGCCCGTGCAGCACTCAGTCGTTACAGCCTGCCTAATGCCCGAGTAGAGGCTCGCTGTGTGCCCTTGGCTAGATTCGCAA
GACCATCCGTTCACGCAGCGGGAAACGCAGGCCCGGGGTGCAGGACTTGCCCCACGCACAGCCGGGTGGCGTGGAGACCC
ACCCCACCCGGTGGGTCCGCGTCAGAGTCCAGACGAGCCTTTGCTCAGGGAAGCGGGCACTGAAGCCGCCTTCCCAGGGT
CCCTAGGGCCAAAGCCTCGGAGGAGGGACCTGGTGGCAGCTGACCTTTGTGTTCTTTGAAGCCAGAGTTTACTAAGCAAA
ATTAGCATGTAAATAAGCTTGGGAAAGGACTGCTGAAACCTCTGACAGTGAACTTTTAATCTTCATTGAGAGTTTTTAAA
ACCATATATTCACATAAATTTAGTGAGTTGCTAATTTTATTACAAAAAAAAAGATTTTACTAGGCAGGACTTAGTTACCG
TAATATATTGAATAATATATATATATACATATGAACACTACAAGCTTTTTTTTTTTACCTTTTTTTTTTTTTAAGAGACG
GGGTCTCACTGTGTTGCCCAGGCTGGTCTGAACTGGGCTCAAGCGATCCTCCCGCCTCGGCCTCCCAAAGTGCTGGGATT
ATAGGCCTGAGCCACCAGGCGCGCCTGGCCTAAAACCATATTCTTTAAAATCCTGTAATTCGGATTTTTCCTCTTGAAAT
TTAAACATTGGCTAATTACTATTTTGAAATAGATTAAGAGGTGTTTTCCTATCTTTTGTCATAAAATAAAGTCCAAGGGA
TGTTTTTATAAACTCTTTGCCATAAAATCACCCATTTTCCGGTTGTGAAGCCGCGTTACTCCTGACATTGTGCGTTTCAC
TGTCCGGCTGGGATCTGGGCGCTGGGAGGTGGAGGGGGCTCCGGGGGGCTCGGTCCTCTCTCCAATATGTAACTTACACA
GGCTGCTGAGTCATTGGCAGTGCAAGGCGGCCAGCGCCGGAGTTACGAGATTTTTGTTTTTCTGTTTTGTTTATTCTATA
AAAAGATAGTTACCCGCGGGGTGGATCCCATGTAGGCGATTCCTTGGGCCGCCCTGAGTGTCCGCGCGGCAGGACGGGGC
CACTGTGGGCTCGGCGTGGGCGGGGTTGGCCGGTCCCGCGGGCTCCAGCTGCCTGCAAATCCGGGACGGAGCGGTGGCTC
AGGCAGCGCTCACCTCTGCCTGTCCGATTTCACTGCCCCTTGTTGACCTCGGAACAGAGAACAATGGGAGCCTTGCAGCC
AGACCCACGGATGGAAGCAGCAAGCACTCTCTCCTCTGAGTGTACCCTCTGGGGCCAACTGCTTTTCCTAAAGAGTTAAT
GGCAAAATGGGCTGATTCTGTTCCTTTCTATCTCTTGATCATTCTAGCTAAAGTTGTTGACTCGCAGGATGCTCGTATTT
GTCCTTTTCCTTTTTTTTACAAGCCCAGTCTTACTCCCCCAGGCTGGAGTGCAGTAGCACAATCATTATAGCTCACTGTA
GCCATGAACTTGGCCCTTTTCTCCTAGACATGTCACTGCTAACATGCAGGAGAGGTAGGATTCTGTGACGAGACCGTGTC
ACGGTGGCGGGGGCATCACTTCCTTGAAGGACCCACTGTCTTCACCAGGAGGGCATCAGTTCAGTAAAGTGCATGCCCAT
TTACTCTGGAGGGCCGTGTTTAATAATCCAAGCCCTCACCTCTTCACCCACTGCTGTGTCTGCAACTGGCAGATGGTTCT
CTCTCTTGTCAGAGGCAACTCACCATGGGCAAAGTTGTATGAGGGGAAAAGATGTTTTCTACTTATTTTGGAGTGGAGTT
GTAGCATTGTGTGCTTTGAGACCTGAAGGGGTTGCAGACATCGAGATTCTCGTCCAAGACTTGCATTTCATAGATGGTCA
CAATGAGGTTCTAGAGGTGGAGTGAAAGATAAGGCTGGCAACAACACTTAAGGAGAAGCCAAGGTCTCTGCATGAGGCAG
CAGTGGGATACCTGGAGCCCAGATGCCTGAGGCTGCGTGCAATAGGCCCTGGAGGGTCCTGGAGGAGAGGAGGCCAGAGG
TCCTGGAGGCAACAGGAAGGTGGAGGGAAACGAGCCCCGTTGGAAGCCAGGGACCTGATTTACCTACCCAGCTGACTTGA
TACTTGAAATCTTTTGTCAGGCGGGTCTCTTTTGTTCTCTCCCCACTAACCTGAGAAGCTTTAAAGGTAAAACAGCAATT
TCTTAGAGCCCACCTCCCCTGGGGAAGAAGCCCTTTGTATGGTTTTGGGGTGCTAGTTCCCTCGGGGGTTCACAGCTCCT
CTGCTTCAGGTTTTTTTTCTGGGATGCTGCCTCCCTCTGTTCTGACATTTATCCCAGAGCTTTTTCAATCTATTTGCCTG
GATTCCACCCCAGCATCCCAAATAGTCACTTTCAGAGTGGGCTGAGGCTAGGCTTTTGGAGAACAATGAAAAAACACCAC
AGGTGATTCTCCCTTCATAGCCAGAGTTGAGGTTGTCACCCCAGGTTAGGGCATAGGGTGGCCTTGAGAACTTGGCCCTG
TGTTTACTCCACGTGGGGCTCGTGGCTGTGGCCCATGAATCCATGTTGAGGAATGGGACCCAGGGAGTTGCCCTGGGACA
TACAGAGGGCAGTGAATCGAAGGGATTCCCTGGAGTCTGTCACTGGAGGGAGAACTGCTTTGGGCACCTAGAAAAGCTGG
ATGTCAGATGATTTTTTTTTTTTTTTTTTACACAAAGTGAGAATAAGAAATGGATTAAGAACTCTTGTTGGACTGTATTT
TGTCTCTGAGGCAGACCTATCAGTTTTCTTTTTGTACTGTGATATAAATATTTATAGTCTAGGCTTTTCAAAATCTCATC
TACCTTGATATAGGAGGGAGGTAAGATTTACTGGCTGTGTGTCTTGTTAGCAATGTAAATTATAAGTGAGTGAGGAGGGG
GAGGAACATGAGAGGGACGCGAAATGAGATTAGGAAGGAGGGCTTTTCTTGCAGCAGCAACAGCAGCACCTTTCCGTCTG
GGGCCTAATTATACTACAGTGATTTGAAGTGTAAACTGCTTGTGATTATGAGCAAGTTTTCTAAGGTTATTAAGCAACCT
TACTGTAAGCCCATCTTTCTTTGAAAAGGTGAACGATCCGAGTGGAGAACTGTAACACGTGAGTAGATACACAGCACGCT
CCATTCTCCAGGAAGTGCCTTCCTTTCCTACGCGGTTGCTGTGGGTTAATAATAAAACTCCTGTCCCTTAGTAAATCATT
CCTGGGAATACAGCTTTTGGGCCCAAAGTCATTAGCCATGGACAATCTGGAGTGAGTTTTTTTTCCTTGTTTCCTGGATT
TTTAGGTCCTTTCTGGGGTGATGTTTAAAAAGCACTGCTTTGGTTCGAATGTGTTCCTCCATGTTGCCAGTGGGATGGTA
GTAAAAGGTGGGCCTTTAAGAGGTGGCTCGGCCATAGGGGCTCCTCTCTAGTGAATGGGATTAGTGCTCTAAGGGGCTGG
ATGGAGGGAGGTGGGTCCCTCTGTAGCCTCATTGAAGGGATGAGGCAGGAAGGCCCTCAGCCGACACCAGATGTTGGTGC
GTGGATCTTGGACTTCCCAGCCTCCAGAACAGAGATCAGTTTCTGTTCGTAAATCACTAAGTCTGTGGGATTCTGTTGCA
GTAGCGCAGAGGATGACAGAGATACACTTGTCTCTCCTTCATCTTCCTCTCCCTGTTGTCTTCAGCCTGCCCCTTGTGTG
ATAGATTACAGTATGTGTTTGGTCTTGACCCTACCTACTTCCTGGTGCAGAGCACCTAAACCCCTGGGGCTTCCTGAGCA
GTGTCTTTTTTTTTTGTTTGAGACACAGAGTTTCGCTATTGTTGCCCAGGCTGGGGGGCAGTGGCATGATCTCGGCTCAC
TGCAACCTCCCCCTCTCAGGTTCAAGGGATTCTTCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGCCCACCACGC
CCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCTGACTCCTGACCTCAGATGA
TCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAACCGCTGTGCCAATAAGTGTCTTAAGCATGTTTATT
AAAGAAAGTAAAACAGTAAAAAGATGGTGACTCCATAGGCAGAACAACCTGACCAGTGTGTGCGTTATTCATAAAGTCAC
CCTATTAGCAGTGTACTCCAAAAGTGCTCCTTGGTTAACCATTTTTGGTGTAAGTTGTAAGGAGCCCCTTCAGAATACAC
TGCTAATACAGTGGCTCAAGGGTGGCCCCAGGATAGTTACTTGAGGTAGAAATTCCCAGGGCAGCCCCTCCTAGGAGGGG
AGGGGACTGGAGATGGAGATGGGGGAGCCATGAGGTGCGGGTAGCATGGTTGGGGTTAGGGTTGGGACATGTGGGGTAAG
TGGGAGTCTGGTTGCAGAGAGTGTGGTTGGGGTTAGGGTTGGGACGTGTGGGGTAGGTGGGGATCTGGGCTGTATGTCAT
TTCCATTTGTCTGCCCTGGAATTGTTTCTGGTAAACTGATAAATGTAAGTAAAGAGTTTTTCTGAGTTCTGTGAATTGTA
GTAAATTACTGAACCTGAGGCAGGTGTGTGGGATCCCCTGAGTAGGTAGAGGCACTGGCAGAAATACGGGTAACCTGGAC
ACCCCATTCTCTGCTTGCATCTGTGGGAACAGTCTTGTGGGCTCCACACTAAGTCTAGGTAGATAGAATGGAATTGAATC
GTTGGACACCCCGGTGGTGGTGACTTGGTGTCCCACATTTGATGTTAAGAGTGGCATCAGAGAAGAGACACCACACCTTC
AAGTTGCATTTGTGTTCCATATCGTCAGATAGCTGAACAACACTTTAGTCAAGTAAATTGAAGCAGGCCCAGAATCTGAA
TACTGTAGATTCAGCGGAGAAAGACAGCTGGCCAAAACAGAGGCTGTGGTGCCGTTCTCTCAGGGGCAGGCCATGGCTAG
CCGGCCGCATGGCATCTTGAACCGCAGAGAGGGAAGGAGGGCTAGTGAACATCAGAGTACTTGGCAATACTGTCTGGTCA
GATGAGCGGCTTCAGGAATGGTGTGGTCTGTACATCTCAGAAGGCACCATGTAGCCTCTGCCAGAGTGTGGGGCAGACTG
GCCTGGGCCTTTCTCCTCCATTGAGCTCCAGGCTCCGAGACAGACCCTGGCTTGCCTTTGTATTAGGGATGTGCTTCGTG
TAGGCCAGGACATGAGGCAACGTGAGAGGCCAAAGAGAACAATCATGCGTTCATTTGAAAATTTGTGTGATCATTTCGTT
AGCAGCTTACTGGGAGACTGTTGATGGCATAAGTTGCAAATCCACTTTTCCTTCCTGGGCCTTCGGTTTGCTTTTTTCTG
GTTAATATGAAATAGACTCTGCAACAAGTGGCGTATGGAGCCTAGGCCAGCCCTCTTTCAGGAGAGATGCCTCGTGTGTG
TGGAAAGCTGTGCACCTGCCTTTGCTTCCAGCGAACATGACGGATGAAGAGGCTGCTCCTTTCCCCCTAATTGCATGGTG
TTATTAGTGCTGTGTTGGTTTAAGGACAGTCAGCAGCTCAGGGTGATTATTCTGCTTACTAAAATTATAGTGACTGCAAA
AATGAGATAATTCCATTGTTCTCGTCCATAAGTTTCCCTGTCTTTTGTGGCCTGCACTTTCCTCCCACTGCACTCCATCC
TCCATACGCTACCAGAGGAAGCTCCTACCAGATTTGCTTTAAATAAATAAACCTATGACACAAAGTAGAGAGATTATCTG
GGGCCCAGAAATAGACGTGTGCCTATATGCACGCTTGATTTCTGACACAGGAAGCAGCCAGCGCAGAGTGAGGCGGGAGC
TGTCTGCAGTAAATGGGGCATCCGTCTCACATCAATGGGAAAATTAATCCATGTAGATTTTGGATCTAAATGTGACTGTC
ATAACAGTAGAGCTGTGTGAAAATAATAGAATAGAATATCTCAGCTCAGGAAGGGATTGCTGCATTTGACTGAATTAAAA
TCAAGAACTTCTGTACATCAGAAGACATCAGAAGTGAAAAGAACAAGCTACCGAGGGAAAGTTACTTGCAACATATTTAA
ATGCAGAAAAACATATATCTAGAATACAGAATTATCCCAGAATTGCACTTTTAGCAGTAAGGGAACGGGAGCAGCGTTCC
AGCCTCAGTTTCTATTTATAATGGTGACATGGAAAAAATACTGCTGGATGCCCACAAATAAGAGAAAGACAGATAATAGA
AAAGAATAAGAGATTCGAAGAACCAGTTCAAAAAAGATGCTATCCAGATGGCTAGCAAACTTGTAAAACCGTCTTCAACC
TCGTTAGAAATTATATAAATGCAAAGTAAGCCACACGATGCAAGTCATAGAGGCTGGGCATGGTGGCTCACGCCTGTAAT
CCCAGCACACTGGGAAGCTGAGGTGAGAGGACTGCTTGGGCCCAGAAGTTCGAGACTAGCCTGGGCAATATAGCGAGACC
CCATCTCCTAAAAAAAATAGCCAGGAGTAGTGGTGCATGCCTGTAGTTCCAGTTATTCCGGAGGTGTCAGCTAGAGGATG
GCCTGAACCCAGGAGTTTGAGATTATAGTGAGCCTTCATCGTGCCACTGCACCCCAGCCTGGGTGACAAAGCGAGACTCC
GTCTCGAAAAGAAACAAAAAATAGAGCTTAAACCTTTTAAAGAAAACTTCAAATCCCTTAAGCTTATGTTGACATTAGTG
TTGTTGTTGTTTTTTTTAAAGACCTCTTTTTCCAAATAATAGCCTTTTTCTTATAAAAGCTCACTGCAAGGAAGTATTCT
AATTGGATTCTGTTGACTCAGCAGAGTTATTGGACATTGGCTTGGTATAAAGGGACTGCAAGAGCTGGACAGATACATGG
TCTCAGCCCCAGGGGGCTTCCTTCCTGTACCCAGGGAGTGTGTGCGTGGACAGTCACTGCCATGAGAGTGGGCAGAGGGA
TGTCTTCAAGTCGGGGTTGAGGGATGGTTCCTGGTGTGGCACCATTGCTACCTCTTGGAAATGGAAGGGCAGGCTGGTTA
GATATCAAGAGCAGATTCCAGAGTGGGTAGAGAATTCCATCTGCGCCCCTTTTTTTGTCCCCATCAGGCTCCTGGGTAGA
ACTGCACTTCAGCAATAATGGGAACGGGGGCAGCGTTCCAGCCTCGGTTTCTATTTATAATGGAGACATGGAAAAAATAC
TGCTGGACGCACAGCATGAGTCTGGACGGAGTAGCTCCAAGAGCTCTCACTGTGACAGGTAGGCGCGCATCAACAAGTGT
ATGTGTTACAGTGCCGATGTCTTCAGTGGGTGACAGTCACAGCTGGAAGTGCCCGTGTCACCTCTAGGACAGTGGGCTGC
TGTTCGCCTCGGGCCGCGTTCTGGACTGGCTCCTGCTGCAGTCCGTCCTTATATAGGAGCCTCGCCCTCTTTGGGGATGC
AGTGACCTGGGACTTAGTCTGTGGGGAGCCATGTTCAAGTCATCAGTAGGCAGCGGAACAGCCACAAACCCCACTCTGAG
AAACGCACTCACGCGCCTCAGCGGGGCTGTGGTCGCAGGAGGAGCGGTCCCTGGTTAGCAGTACTTCTGAGTGACTCCAA
GGTAGAGTGGCCGACAGTGGTCAAAGGTCGCGTGCCCTTGAGAGCTGTGCAACAGACCCAGACCGTGAAGGCGGCAGGTG
ACAAAGCCAGCTGCTTGCCAGTTGCCCCTGCGTCTTCTCTGGAAGACTGGCTAGCTCACTCCTGTCGTGCTCAGCCAAAA
GGGCTGAGGAAGAGTTTGGCTCTGGCAGGTGCTGGGTGGAAGGGAAGACGCGTACGCTGACTGGCTAGAGCCCCTCATCA
CGGAGGCGGTTCACTGCCTTTGGGGTTTGAGCTTCTAATGATAGAATGTTCACATGATGTTCTGTTTTTCCCATTCTATT
CACATCGCCAAGCCCACCTCGCTCGCAGACACCACAAGATACCAACAGAGCTTCTGAAACAGATACCCATAGCATTGGAG
AGAAAAACAGCTCACAGGTAAGCTGGAAGGAGAATGTGCAGTTGTAAAAGTATTTGTGATCTGTTTGTACAGGAAACGGT
TTTAAATGTAATTGAGCACCTCAGAGAAAAGTCGGGCTTTAAGGGTGTTTCCTGCTTTAAAAAAAACAAAAAAGCGAAAC
AAAAAAACCAAGAAACTGTGGGTGGGAACATCCACAAGCACATGGGCTGGACACTCAGCTGAGCGGGGGAGGCGCCGAGT
GGGACAGGCAGCGGGGGCCTCCTGTCCCTCCCTGCCTGCCATCAGGGATACACCGGAAAGGAGGAAGGGCTCCCTGGTGG
CTGCAGCCTAGAGAGGAGGGAGGGACCATTGGAAGGGGTGGCAGTGAGCCAGCTACTGGCTGGTCTTTCCTCGTGGTTGC
TGGTTGGACAGTGAGTGGGTTTTAATATTTGCATGCTGTGTGGGACTCAGGAGTTACCCACGGGGCCATCTAAGGCCATG
TGGCCACTGTGGCTGTGACTCTGAGGTGTCTTCCTCATTAGACACTCACTACCTGCCGGAAATTACACCCTGTGCCTTTC
CTAGCATTAGTCCTGAGCTAACTGGTGCCGGAGCAGTGTAGCATTAGCGGCTGATCAGCCTGATAATTTAGTGTAAGATC
ACTTTTTCTTCTTTTTTAAAAAAGTTTTTTTTGTAGAGACGGGGTCTCCCTGTGTTGCCCAGGGTGGTCTTGAACTCCAG
GGCTCAAGTGATCCTCCCAAAATACTGGGACTATAGGTGTGAGATACTGTGTCCAGCCTAAGATGACTTTTCTGTTAACA
GCTATTGAATGGGCTTTACAGAGCGGCCTTCAGCATTGTTGTGAAAGCGGAGTGAGTCTTAGAGGAAAAAGTGTACCTGG
GGTTATTGCCTTGGTGTACTATCGTTCTCCCTTCCTACTCCGGCACAGATAGGGTTCGAGGCAGTGATCAGTACTGTCTT
GCTCAGTTATATCTGGCAGTGCCTTACCTTGCTGCAGATGAGATGCGCGATGTGTTTTCTTGGGTGTTCGTTGCTGGTGA
GAACTTTGACGACGGACTGTGTTCTGTATTTTGGAAGCTCTGTGAGGAAGCATGGCCTTCCAGGCAGGGTTAGTAGCTGA
CCCTTCCGTGCTAGCGCTTCCCTCAAGGCTTTCTTCACCAAGGAAACAAGGAGTCCCTGTTACCCAGGCTTTCTCAGGGA
CATCCCCTGGCCCCACTCCGAGGGGCAGCATGATTTCGGGAGCCCCAGGAGCCCTGGCTGTGGGTGTGTGGGTGCATCCA
GGGCGTGCGGCCTGCTCCTGGGCACTTGGGGCTGTACCCAGCTTGGGTGTACCCAGATGTTTGGTGGGTTTGGGGAGCTA
TATTCTTGAGTATTTTCAATTTTATTTCTTTTTTTTTGAGACAGGGTCTTGCCGTTTTCACTGTTTTACACAAAACTTCC
CCTAGTTTTAAAAGGAATTAGATGTTCAGGTACAGAATTTTGAAAATGCAAAAAAGTAGAGAAAAACACTTAGACTCTCA
GATTTAAAATCCTCTTTAATGTTTCGTGCTGTTATATAATTCTGAGGATTTGGCCGCAGCTGTGGTTATGTGGACATTTC
TGCCTTTTCCCTCCTGCTTATCCCGGAAGCATCTTGTAAACCTGCTCACTATACAGTGTCCCTTCCTTCGTCATGTCCCT
GTTTTGAGCCGTTTTCGGCTGTTTTCATTTTCTTTTCTTATAACCAGTGCTGCCGTCACCATCTTTGCCCTCATGTCACG
TGACTTCCCTAGGACAGTGTTTGCCGCTGTCAGTACCCCCAGAATCTCACAGTGAACCAAATGTATTTACGCCCTGAGTG
GGGCTCCCCCAGAGGTGATCTGTCCCTGGAGGCGGCGAGCGTGCTGTGAGCCGGGAGTGCGGCGCGGCCCGGGGAAGGCC
CCCAGCCCCAGGACTCCCCTTGGACCACGGTCCGAGGCACTGACATGTGCCTCTGGGCTCTTGAATTGAGCCTGCGGATC
TGAAGCTCGGGTGGGAGCTGGGTGCTTTCCCGTGTCACGTGTGGTACACTGATCTGCCTTTAACATTGACTTTATCTTAG
TCTGAGGAAGATGATATTGAAAGAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAACTCAGATTGGATATGGGATTGGTC
AAGTCGGCCGGAAAATATTCCCCCCAAGTGAGTGTGTTCTCAGTGTCACGGGGGCACCCCTTGACAGAGGACACATCAGC
TGACACGTTTCTTCCCGCCTCAGGGAGTTCCTCTTTAAACACCCGAAGCGCACGGCCACCCTCAGCATGAGGAACACGAG
CGTCATGAAGAAAGGGGGCATATTCTCTGCAGAATTTCTGAAAGTTTTCCTTCCATCTCTGCTGCTCTCTCATTTGCTGG
CCATCGGATTGGGGTAGGTGATGTGACTGTGTGACTCCTGTCATGGCATGTCGTGGGGCGATTCTGGGTTGCAGTGATTT
ATTCGTAACCTGTTTCCTGAAGTCCAGATCATCAGTTACAGCTTGGTGCATTTTCACAAACACCCACGTAGTCACTGTTC
AGGTCCAGAAACCACCAGCCTGCAGCCCCCAAAGGCCCCAGCACAGGCGCCCTGTGGTGCTGCTGTCTGGCCTGACGAGT
CTGCCTGTTGCTCACTGAATATAAACGGAGTCAAAGCAGGGCTTCTTAGGTCTGACCTCTTTGTCCTGTGTGTAGGTGAA
AGCAGTCTCATTTCTGTGTAGTACTGTGGCGGGAATGCACCCAGCTCTGCTGTAGGTGGAGGGTCTCAGTTACCTGCTGT
ACTTCCTCCAGACAGGACTGTTGTTCTAGTAACTCTCAGCAATGAAGGAACCAATGCAGTCTCCGACTTTACTGGCTTGA
GTTTCGCTCTTGTTGCCCAGGCTGAGTGCAGGGGCGTGATCTCGGCTCACTGCAGCCTCTGCCTCCTGGGTTCAAGCGAC
TCTCCTGCCTCAGCCTCCTGGGTAGCTGGGATTACAGGTGCCCACCACCAGGCCTGGCTAATTTTTGTATTTTTAATAGA
GACGGGGCTTCGCCACGTTGCCCAGGCTGATCTCGAACTCAAGGGATGGCTCACCTCGGCCTCCAAAGTGCTGGGATTAC
AGGCGTGAGCCACCGCGCCTGGCCTTTCCTGGCTGCTTATACTCACTCACCCTGCAGAAAACACAGAGACCAGGCAGGCG
CCGCTGTGGGTTCTGAAGAGCGTTCGCCGCAGCGGTGGTGAAGAGCCAGAGCGGGAAGCCAAAACGGCTCCTCCTCGGGC
TGGTCCCAGCCTCTCAGCGGGGAGGAGGGCTCTAGTCCTGGCGTGCAGACAGTGTTCTGTGGCTGCCGTGTGTTGGACAG
ACTGGAAAGACCGGAATGCCACTGGGGGCAGGTGGGTTAGGTAGGTTGGCCAGAGGGCTCACATCTGGGGTTGAAGGAAA
CGGGATAAAAGCCACTGAGTTTCCTGGGCCGGGACCTGAGCGCTGCCCGTGTCTCCACCTCGCCCTCCCGTGTGCGTGGC
TTTCTCCTAGCTCTTGGGCACATTCTCACGTCCCCCCCATAACCCGTCACCTTCATTTCTGCTGGTGCTTTTGGGAGTCA
GACCTACAGACTGCATCAGCATCACCAGGCAGTTTGCTTTCTGGAGCCTTTTCCAGAACTGTCAAGCAGACTCTGGGGGC
AAGGCCTCGGGATCCTCATTTTAAATACAAGGTTTAAGCCCTTCGTTTCAGGATGGATTTCTGCAGCCACTACTTCCCAG
CTACTGTCCTTCGTCCTGCCCGGGTTTTCAGAGCCTGATGCTGCCACTGGCGACCCACACCCCCTCAGCTGCTTTTCAGA
ACCACACGATAAAATCTGCCCCGAAAGCTGCTGCAGCACTGTCTGCGCTCACAGTGCCCACCACACCACCGCCCACAGGC
CAGGCCAGCCAGGCTTCCGATTCTGCCCTTTCCTGGAGACCCATCCTCCTCCCTCCGGGAGTGATGCCCGCTGGTCAGCT
GGAGCGAGCCTCTCTATTGCCGAAAAGCCTTTTCTGACACTCCTGCATCTTTAGTTTGGGACATCTCTCCCACTACCAAA
CTTAAACCACATGAGGGCAGGGGCTTCATTTTTAAGCAGTTGGCTTTGGTGAGGCTGGTGGTGATGAACTAGCAACACCA
TCTTGCCCTGGTAGGTGACTTCCCCCAGCACTGAGTTGGAACAAAGCAGAAGCTTTCTGTGTGGAAACAGCATTCGGTTT
GGTGATCCTTCTATGTAAGAATACGATCTGATGTTTTCTAAGTTAATTAATACAAAATACATATTGATAAAACACTAGAT
AAAAGATCACAGATAGATTCATTACAAAATTTTTATAATGGGTATAAAATCACCAGTCCCCTTGCATAAGCTCTAACCAC
AGTGAGCTACCCTGTTTCAGCTGTAACACAGTCTCCTGTGAATCACAAGATACATTAACTACTGATAATTTTTCTGTGAA
GGATCTATATTGGAAGGCGTCTGACAACCTCCACCAGCACCTTTTGATGAAGAACTGGAGTCTGACTTGGTTCGTTAGTG
GATTACTTCTGAGCTTGCAACATAGCTCACTGAAGAGCTGTTAGATCCTGGGGTGGCCACGTCACTTGTGTTTATTTGTT
CTGTAAATGCTGCGTTCCTAATTTAGTAAAATAAAAGAATAGACACTAAAATCATGTTGATCTATAATTACACCTATGGG
ATCAATAAGCATGTCAGACTGATTAATGTCTACTGTGAAAATTTGGTAGTAAATTTTCATTTGATATTAGATATAAATAT
CTGAATATAAATAATTTTAATATACTAGTCATGATGTGTGTTGTATTTTAAAAATTATCTGCAACCTTAATTCAGCTGAA
GTACTTTATATTTCAAAAGAATGAATAACATTGATAATAAAATCGCTACTTTAAGGGGTTTGTCCAAAATAAATATTGTG
GCCTTATATATCACACTATTGTAGAAAGTATTATTTAATTTAAATGGATGCAGGTTGTCTACTAAAGAAAGATTATATAT
AACTATGCTAATTGTTCATAATCAACAGAAACCAAGATAGAGCTACAAACTCAGCTGTACAGTTCGTACACTAAACTCTT
CTTGCTTTTGCATTATAAGGAATTAAGTCTCCGATTATTAGGTGATCACCCTGGATGATCAGTTTTCTGCTGAAGGCACC
TACTCAGTATCTTTTCCTCTTTATCACTCTGCATTGGTGAATTTAATCCTCTCCTTTGTGTTCAACTTTTGTGTGCTTTT
AAAATCAGCTTTATTCTAAGCAAATCTGTGTCTACTTTAAAAAACTGGAAATGGAAAAAAAAATAAATCTTT
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Primary source |
RefSeq : NM_004052.2 (GI:7669480)
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Name |
BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3), nuclear gene encoding mitochondrial protein
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
1535 nt
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Map |
10q26.3
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Location |
Chromosome 10 (NC_000010.10) strand : -
133781203...133782072 | 133784141...133784290 | 133784367...133784473 | 133786537...133786621 |
133787296...133787446 | 133795264...133795434 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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2
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172
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171
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1
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Exon 2
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173
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323
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151
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1
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Exon 3
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324
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408
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85
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1
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Exon 4
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409
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515
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107
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1
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Exon 5
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516
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665
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150
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1
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Exon 6
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666
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1535
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870
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1
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Primary source |
NCBI : CCDS7663
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Nucleotide |
BNIP3, mRNA isoform 1[NM_004052.2] : 127...711
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Length |
585
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Location |
Chromosome 10 (NC_000010.10) strand : -
133782027...133782072 | 133784141...133784290 | 133784367...133784473 | 133786537...133786621 |
133787296...133787446 | 133795264...133795309 |
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Start codon |
1
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Translation |
NP_004043.2 |
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1 |
CCTCCGCTCA |
GTCCGGGAGC |
GCACGTGGGC |
CGCGGCGCTC |
CGACCTCCGC |
TTTCCCACCG |
CCCGCAGCTG |
AAGCACATCC |
|
81 |
CGCAGCCCGG |
CGCGGACTCC |
GATCGCCGCA |
GTTGCCCTCT |
GGCGCCATGT |
CGCAGAACGG |
AGCGCCCGGG |
ATGCAGGAGG |
|
161 |
AGAGCCTGCA |
GGGCTCCTGG |
GTAGAACTGC |
ACTTCAGCAA |
TAATGGGAAC |
GGGGGCAGCG |
TTCCAGCCTC |
GGTTTCTATT |
|
241 |
TATAATGGAG |
ACATGGAAAA |
AATACTGCTG |
GACGCACAGC |
ATGAGTCTGG |
ACGGAGTAGC |
TCCAAGAGCT |
CTCACTGTGA |
|
321 |
CAGCCCACCT |
CGCTCGCAGA |
CACCACAAGA |
TACCAACAGG |
GCTTCTGAAA |
CAGATACCCA |
TAGCATTGGA |
GAGAAAAACA |
|
401 |
GCTCACAGTC |
TGAGGAAGAT |
GATATTGAAA |
GAAGGAAAGA |
AGTTGAAAGC |
ATCTTGAAGA |
AAAACTCAGA |
TTGGATATGG |
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481 |
GATTGGTCAA |
GTCGGCCGGA |
AAATATTCCC |
CCCAAGGAGT |
TCCTCTTTAA |
ACACCCGAAG |
CGCACGGCCA |
CCCTCAGCAT |
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561 |
GAGGAACACG |
AGCGTCATGA |
AGAAAGGGGG |
CATATTCTCT |
GCAGAATTTC |
TGAAAGTTTT |
CCTTCCATCT |
CTGCTGCTCT |
|
641 |
CTCATTTGCT |
GGCCATCGGA |
TTGGGGATCT |
ATATTGGAAG |
GCGTCTGACA |
ACCTCCACCA |
GCACCTTTTG |
ATGAAGAACT |
|
721 |
GGAGTCTGAC |
TTGGTTCGTT |
AGTGGATTAC |
TTCTGAGCTT |
GCAACATAGC |
TCACTGAAGA |
GCTGTTAGAT |
CCTGGGGTGG |
|
801 |
CCACGTCACT |
TGTGTTTATT |
TGTTCTGTAA |
ATGCTGCGTT |
CCTAATTTAG |
TAAAATAAAA |
GAATAGACAC |
TAAAATCATG |
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881 |
TTGATCTATA |
ATTACACCTA |
TGGGATCAAT |
AAGCATGTCA |
GACTGATTAA |
TGTCTACTGT |
GAAAATTTGG |
TAGTAAATTT |
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961 |
TCATTTGATA |
TTAGATATAA |
ATATCTGAAT |
ATAAATAATT |
TTAATATACT |
AGTCATGATG |
TGTGTTGTAT |
TTTAAAAATT |
|
1041 |
ATCTGCAACC |
TTAATTCAGC |
TGAAGTACTT |
TATATTTCAA |
AAGAATGAAT |
AACATTGATA |
ATAAAATCGC |
TACTTTAAGG |
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1121 |
GGTTTGTCCA |
AAATAAATAT |
TGTGGCCTTA |
TATATCACAC |
TATTGTAGAA |
AGTATTATTT |
AATTTAAATG |
GATGCAGGTT |
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1201 |
GTCTACTAAA |
GAAAGATTAT |
ATATAACTAT |
GCTAATTGTT |
CATAATCAAC |
AGAAACCAAG |
ATAGAGCTAC |
AAACTCAGCT |
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1281 |
GTACAGTTCG |
TACACTAAAC |
TCTTCTTGCT |
TTTGCATTAT |
AAGGAATTAA |
GTCTCCGATT |
ATTAGGTGAT |
CACCCTGGAT |
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1361 |
GATCAGTTTT |
CTGCTGAAGG |
CACCTACTCA |
GTATCTTTTC |
CTCTTTATCA |
CTCTGCATTG |
GTGAATTTAA |
TCCTCTCCTT |
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1441 |
TGTGTTCAAC |
TTTTGTGTGC |
TTTTAAAATC |
AGCTTTATTC |
TAAGCAAATC |
TGTGTCTACT |
TTAAAAAACT |
GGAAATGGAA |
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1521 |
AAAAAAATAA |
ATCTT |
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>gi|7669480|ref|NM_004052.2|BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3), nuclear gene encoding mitochondrial protein
CCTCCGCTCAGTCCGGGAGCGCACGTGGGCCGCGGCGCTCCGACCTCCGCTTTCCCACCGCCCGCAGCTGAAGCACATCC
CGCAGCCCGGCGCGGACTCCGATCGCCGCAGTTGCCCTCTGGCGCCATGTCGCAGAACGGAGCGCCCGGGATGCAGGAGG
AGAGCCTGCAGGGCTCCTGGGTAGAACTGCACTTCAGCAATAATGGGAACGGGGGCAGCGTTCCAGCCTCGGTTTCTATT
TATAATGGAGACATGGAAAAAATACTGCTGGACGCACAGCATGAGTCTGGACGGAGTAGCTCCAAGAGCTCTCACTGTGA
CAGCCCACCTCGCTCGCAGACACCACAAGATACCAACAGGGCTTCTGAAACAGATACCCATAGCATTGGAGAGAAAAACA
GCTCACAGTCTGAGGAAGATGATATTGAAAGAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAACTCAGATTGGATATGG
GATTGGTCAAGTCGGCCGGAAAATATTCCCCCCAAGGAGTTCCTCTTTAAACACCCGAAGCGCACGGCCACCCTCAGCAT
GAGGAACACGAGCGTCATGAAGAAAGGGGGCATATTCTCTGCAGAATTTCTGAAAGTTTTCCTTCCATCTCTGCTGCTCT
CTCATTTGCTGGCCATCGGATTGGGGATCTATATTGGAAGGCGTCTGACAACCTCCACCAGCACCTTTTGATGAAGAACT
GGAGTCTGACTTGGTTCGTTAGTGGATTACTTCTGAGCTTGCAACATAGCTCACTGAAGAGCTGTTAGATCCTGGGGTGG
CCACGTCACTTGTGTTTATTTGTTCTGTAAATGCTGCGTTCCTAATTTAGTAAAATAAAAGAATAGACACTAAAATCATG
TTGATCTATAATTACACCTATGGGATCAATAAGCATGTCAGACTGATTAATGTCTACTGTGAAAATTTGGTAGTAAATTT
TCATTTGATATTAGATATAAATATCTGAATATAAATAATTTTAATATACTAGTCATGATGTGTGTTGTATTTTAAAAATT
ATCTGCAACCTTAATTCAGCTGAAGTACTTTATATTTCAAAAGAATGAATAACATTGATAATAAAATCGCTACTTTAAGG
GGTTTGTCCAAAATAAATATTGTGGCCTTATATATCACACTATTGTAGAAAGTATTATTTAATTTAAATGGATGCAGGTT
GTCTACTAAAGAAAGATTATATATAACTATGCTAATTGTTCATAATCAACAGAAACCAAGATAGAGCTACAAACTCAGCT
GTACAGTTCGTACACTAAACTCTTCTTGCTTTTGCATTATAAGGAATTAAGTCTCCGATTATTAGGTGATCACCCTGGAT
GATCAGTTTTCTGCTGAAGGCACCTACTCAGTATCTTTTCCTCTTTATCACTCTGCATTGGTGAATTTAATCCTCTCCTT
TGTGTTCAACTTTTGTGTGCTTTTAAAATCAGCTTTATTCTAAGCAAATCTGTGTCTACTTTAAAAAACTGGAAATGGAA
AAAAAAATAAATCTT
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Exon number |
1
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Length |
171 nt
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Location |
Chromosome 10 (NC_000010.10) : 133795264...133795434 (-)
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Is part of |
BNIP3, mRNA isoform 1
(NM_004052.2)
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Sequence |
Show
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CTCCGCTCAGTCCGGGAGCGCACGTGGGCCGCGGCGCTCCGACCTCCGCTTTCCCACCGCCCGCAGCTGAAGCACATCCC
GCAGCCCGGCGCGGACTCCGATCGCCGCAGTTGCCCTCTGGCGCCATGTCGCAGAACGGAGCGCCCGGGATGCAGGAGGA
GAGCCTGCAGG
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Exon number |
2
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Length |
151 nt
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Location |
Chromosome 10 (NC_000010.10) : 133787296...133787446 (-)
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Is part of |
BNIP3, mRNA isoform 1
(NM_004052.2)
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Sequence |
Show
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GCTCCTGGGTAGAACTGCACTTCAGCAATAATGGGAACGGGGGCAGCGTTCCAGCCTCGGTTTCTATTTATAATGGAGAC
ATGGAAAAAATACTGCTGGACGCACAGCATGAGTCTGGACGGAGTAGCTCCAAGAGCTCTCACTGTGACAG
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Exon number |
3
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Length |
85 nt
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Location |
Chromosome 10 (NC_000010.10) : 133786537...133786621 (-)
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Is part of |
BNIP3, mRNA isoform 1
(NM_004052.2)
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Sequence |
Show
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CCCACCTCGCTCGCAGACACCACAAGATACCAACAGGGCTTCTGAAACAGATACCCATAGCATTGGAGAGAAAAACAGCT
CACAG
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Exon number |
4
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Length |
107 nt
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Location |
Chromosome 10 (NC_000010.10) : 133784367...133784473 (-)
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Is part of |
BNIP3, mRNA isoform 1
(NM_004052.2)
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Sequence |
Show
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TCTGAGGAAGATGATATTGAAAGAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAACTCAGATTGGATATGGGATTGGTC
AAGTCGGCCGGAAAATATTCCCCCCAA
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Exon number |
5
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Length |
150 nt
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Location |
Chromosome 10 (NC_000010.10) : 133784141...133784290 (-)
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Is part of |
BNIP3, mRNA isoform 1
(NM_004052.2)
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Sequence |
Show
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GGAGTTCCTCTTTAAACACCCGAAGCGCACGGCCACCCTCAGCATGAGGAACACGAGCGTCATGAAGAAAGGGGGCATAT
TCTCTGCAGAATTTCTGAAAGTTTTCCTTCCATCTCTGCTGCTCTCTCATTTGCTGGCCATCGGATTGGG
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Exon number |
6
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Length |
870 nt
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Location |
Chromosome 10 (NC_000010.10) : 133781203...133782072 (-)
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Is part of |
BNIP3, mRNA isoform 1
(NM_004052.2)
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Sequence |
Show
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GATCTATATTGGAAGGCGTCTGACAACCTCCACCAGCACCTTTTGATGAAGAACTGGAGTCTGACTTGGTTCGTTAGTGG
ATTACTTCTGAGCTTGCAACATAGCTCACTGAAGAGCTGTTAGATCCTGGGGTGGCCACGTCACTTGTGTTTATTTGTTC
TGTAAATGCTGCGTTCCTAATTTAGTAAAATAAAAGAATAGACACTAAAATCATGTTGATCTATAATTACACCTATGGGA
TCAATAAGCATGTCAGACTGATTAATGTCTACTGTGAAAATTTGGTAGTAAATTTTCATTTGATATTAGATATAAATATC
TGAATATAAATAATTTTAATATACTAGTCATGATGTGTGTTGTATTTTAAAAATTATCTGCAACCTTAATTCAGCTGAAG
TACTTTATATTTCAAAAGAATGAATAACATTGATAATAAAATCGCTACTTTAAGGGGTTTGTCCAAAATAAATATTGTGG
CCTTATATATCACACTATTGTAGAAAGTATTATTTAATTTAAATGGATGCAGGTTGTCTACTAAAGAAAGATTATATATA
ACTATGCTAATTGTTCATAATCAACAGAAACCAAGATAGAGCTACAAACTCAGCTGTACAGTTCGTACACTAAACTCTTC
TTGCTTTTGCATTATAAGGAATTAAGTCTCCGATTATTAGGTGATCACCCTGGATGATCAGTTTTCTGCTGAAGGCACCT
ACTCAGTATCTTTTCCTCTTTATCACTCTGCATTGGTGAATTTAATCCTCTCCTTTGTGTTCAACTTTTGTGTGCTTTTA
AAATCAGCTTTATTCTAAGCAAATCTGTGTCTACTTTAAAAAACTGGAAATGGAAAAAAAAATAAATCTT
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Primary source |
Uniprot : Q12983
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Name |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
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Alternative name(s) |
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Synonym(s) |
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Organism |
Homo sapiens
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Length |
194 aa
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Protein existence |
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General annotation (Comments)
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Function
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Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.
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Similarity
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Belongs to the NIP3 family.
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Subcellular location
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Mitochondrion membrane; Single-pass membrane protein (Potential). Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope.
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Subunit
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Homodimer. Binds to BCL2. Interacts with BNIP3L. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1.
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Biological process
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response to hypoxia [GO:0001666]
DNA fragmentation involved in apoptotic nuclear change [GO:0006309]
chromatin remodeling [GO:0006338]
oxygen and reactive oxygen species metabolic process [GO:0006800]
induction of apoptosis [GO:0006917]
negative regulation of survival gene product expression [GO:0008634]
interspecies interaction between organisms [GO:0044419]
negative regulation of membrane potential [GO:0045837]
regulation of mitochondrial membrane permeability [GO:0046902]
neuron apoptosis [GO:0051402]
defense response to virus [GO:0051607]
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Cellular component
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nuclear envelope [GO:0005635]
nucleoplasm [GO:0005654]
dendrite [GO:0030425]
integral to mitochondrial outer membrane [GO:0031307]
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Molecular function
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protein homodimerization activity [GO:0042803]
protein heterodimerization activity [GO:0046982]
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Alternative product(s)
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Feature key |
Position
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Length
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Description
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Feature identifier
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Region |
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Transmembrane
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164 - 184
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21
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Helical; (Potential)
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Q12983-TRANSMEM-164
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Amino acid modifications |
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Modified residue
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86 - 86
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1
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Phosphoserine (By similarity)
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Q12983-MOD_RES-86
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Modified residue
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92 - 92
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1
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Phosphoserine (By similarity)
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Q12983-MOD_RES-92
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Modified residue
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93 - 93
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1
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Phosphoserine
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Q12983-MOD_RES-93
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Modified residue
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95 - 95
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1
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Phosphoserine (By similarity)
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Q12983-MOD_RES-95
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1 |
MSQNGAPGMQ |
EESLQGSWVE |
LHFSNNGNGG |
SVPASVSIYN |
GDMEKILLDA |
QHESGRSSSK |
SSHCDSPPRS |
QTPQDTNRAS |
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ETDTHSIGEK |
NSSQSEEDDI |
ERRKEVESIL |
KKNSDWIWDW |
SSRPENIPPK |
EFLFKHPKRT |
ATLSMRNTSV |
MKKGGIFSAE |
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161 |
FLKVFLPSLL |
LSHLLAIGLG |
IYIGRRLTTS |
TSTF |
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>sp|Q12983|BNIP3_human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
MSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRAS
ETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSAE
FLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF
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