(VAMP7) vesicle-associated membrane protein 7 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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93
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Official symbol
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VAMP7
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Official name
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vesicle-associated membrane protein 7
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome X (NC_000023.10) : 155110946...155173432 (+)
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Map
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Xq28 and Yq12
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Length
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62487 nt
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NM_005638.4
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VAMP7, mRNA isoform 1
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NM_001145149.1
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VAMP7, mRNA isoform 2
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Accession
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Name
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Organism
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Length
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P51809
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Vesicle-associated membrane protein 7
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Homo sapiens
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220 aa
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Synonyms |
TIVAMP; VAMP-7; TI-VAMP; SYBL1
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Alternative name(s) |
tetanus insensitive VAMP (Ti-VAMP); synaptobrevin-like 1
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Summary |
Exocytosis of vesicle contents requires fusion of opposing membrane layers, and the highly conserved proteins of the SNARE family are crucially involved in this process. SNAREs localized to the vesicle membrane, or v-SNAREs, include VAMP7, and SNAREs localized to the target membrane, or t-SNARES, include the SNAPs (see SNAP25; MIM 600322) and the syntaxins (see STX1A; MIM 186590). The SNARE proteins assemble into a core complex of bundled helices and thereby contribute to membrane fusion (Sander et al., 2008 [PubMed 18253931]).[supplied by OMIM].
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Related Articles in PubMed
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Go to ensembl
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>ref|Gene_ID:6845|VAMP7|NC_000023.10:155110946...155173432 (+)
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Primary source |
RefSeq : NM_005638.4 (GI:223468572)
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Name |
Vesicle-associated membrane protein 7 (VAMP7), transcript variant 1
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
2660 nt
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Map |
Xq28 and Yq12
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Location |
Chromosome X (NC_000023.10) strand : +
155110946...155111110 | 155119120...155119274 | 155125285...155125342 | 155127775...155127912 |
155130160...155130250 | 155149476...155149543 | 155169364...155169456 | 155171546...155173432 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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165
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165
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1
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Exon 2b
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166
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320
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155
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1
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Exon 3
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321
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378
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58
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1
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Exon 4
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379
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516
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138
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1
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Exon 5
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517
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607
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91
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1
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Exon 6
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608
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675
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68
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1
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Exon 7
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676
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768
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93
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1
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Exon 8
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769
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2655
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1887
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1
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ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
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Primary source |
NCBI : CCDS14770
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Nucleotide |
VAMP7, mRNA isoform 1[NM_005638.4] : 175...837
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Length |
663
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Location |
Chromosome X (NC_000023.10) strand : +
155119129...155119274 | 155125285...155125342 | 155127775...155127912 | 155130160...155130250 |
155149476...155149543 | 155169364...155169456 | 155171546...155171614 |
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Start codon |
1
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Translation |
NP_005629.1 |
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1 |
GAGGAGCGCT |
CCCACTCCCA |
AGAGGCCACG |
CGTAGACGGG |
GCGCTTCATG |
CGGAAGTCAG |
CGGCGTCCGG |
TCCCAGCCTC |
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81 |
CTCTGGGAGC |
GGGCAGTTGG |
CGACCCTGCA |
CTGACCCGCG |
TCCCTCCGTC |
CCGAGCCCGC |
GCGCCCTCAG |
AGGGTGCCCG |
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161 |
GACAGACTGA |
AGCCATGGCG |
ATTCTTTTTG |
CTGTTGTTGC |
CAGGGGGACC |
ACTATCCTTG |
CCAAACATGC |
TTGGTGTGGA |
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241 |
GGAAACTTCC |
TGGAGGTGAC |
AGAGCAGATT |
CTGGCTAAGA |
TACCTTCTGA |
AAATAACAAA |
CTAACGTACT |
CACATGGCAA |
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321 |
TTATTTGTTT |
CATTACATCT |
GCCAAGACAG |
GATTGTATAT |
CTTTGTATCA |
CTGATGATGA |
TTTTGAACGT |
TCCCGAGCCT |
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401 |
TTAATTTTCT |
GAATGAGATA |
AAGAAGAGGT |
TCCAGACTAC |
TTACGGTTCA |
AGAGCACAGA |
CAGCACTTCC |
ATATGCCATG |
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481 |
AATAGCGAGT |
TCTCAAGTGT |
CTTAGCTGCA |
CAGCTGAAGC |
ATCACTCTGA |
GAATAAGGGC |
CTAGACAAAG |
TGATGGAGAC |
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561 |
TCAAGCCCAA |
GTGGATGAAC |
TGAAAGGAAT |
CATGGTCAGA |
AACATAGATC |
TGGTAGCTCA |
GCGAGGAGAA |
AGATTGGAAT |
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641 |
TATTGATTGA |
CAAAACAGAA |
AATCTTGTGG |
ATTCTTCTGT |
CACCTTCAAA |
ACTACCAGCA |
GAAATCTTGC |
TCGAGCCATG |
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721 |
TGTATGAAGA |
ACCTCAAGCT |
CACTATTATC |
ATCATCATCG |
TATCAATTGT |
GTTCATCTAT |
ATCATTGTTT |
CACCTCTCTG |
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801 |
TGGTGGATTT |
ACATGGCCAA |
GCTGTGTGAA |
GAAATAGGAA |
AGAAGAAGTT |
ACCATTAACC |
AAGGATATGA |
GAGAACAAGG |
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881 |
AGTTAAAAGC |
AATCCATGTG |
ACTCAAGCCT |
TTCACATACT |
GACAGATGGT |
ATCTGCCAGT |
CTCTTCAACC |
CTCTTCTCAC |
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961 |
TTTTTAAAAT |
CTTGTTCCAT |
GCCTCCAGGT |
TTATCTTTGT |
CTTATCTACC |
AGTTTATTCC |
TGTGAACTTC |
AGATTGAACC |
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1041 |
ATTCATTGCA |
GCAGTAGCCT |
TAAAAAGGCT |
TTTGTTTATT |
TCTTTGGTTT |
GTTAACTAGT |
GTCATCTATT |
TAGAGAAACA |
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1121 |
TTTTTGTTTT |
TAATTGCTCA |
AAGCTGTCGC |
CGCTAGTCTT |
ATGAGCTATC |
TACTAAAACT |
ATGGAGAAAC |
TTTGTATGTG |
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1201 |
CACACAAAAG |
TATTCAAGAG |
ACAGTATTGC |
TAACATCTCA |
TCTTAATGTC |
TTTTGTTATT |
GAGAAGTTTT |
AGGTGCTTCA |
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1281 |
AAACAATATA |
AATGGATAAT |
AGTTGTTATT |
TGGGGAATTG |
TAATGATGTT |
GGTGCTGCTT |
CCTTCTAAGA |
GCTCAGACAA |
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1361 |
GTAAAGTATG |
AAACATTCTT |
ATTTCAGTTA |
GATGGGGAAC |
ATTTTGCTAG |
CCCATTAGAA |
GCACACAGAA |
TTATCCTTGT |
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1441 |
CCTCCTAATA |
TTGACTTTCA |
GGAATAAAGT |
TCAGTGTGCT |
GATCATTCAC |
AATACAGTGG |
ATAGCTTGAT |
ATCTTCTGTT |
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1521 |
TTCCCATTGC |
AGTTGATTTG |
AGAAGATGAA |
GGTTTAAATA |
TTGTTGAAAG |
TTGCAGTTTT |
TTAAATGTGT |
TCCTTTTTCT |
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1601 |
TCTGTGAATA |
TTTAGGGCAA |
TCGTGTCGCT |
AATAGAATAT |
GTAGTAGAGG |
GGGTGGGGAG |
GTAAATTCCT |
CTGACTTGCC |
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1681 |
AAAGAAAAAG |
AAGGGAACCA |
CAGTGGATAT |
GCTAGCATTT |
TAGCTGTGCA |
AAGGGAGGTA |
GTGTGGGAAA |
AGTGTTTCCA |
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1761 |
TTCTGGGAAA |
AGCCCAAACC |
GAATACGGTC |
AGCAGTCAAC |
TCCAGGGTTT |
GGGCTTGATT |
CCTGTTGAAT |
AATAGTTTTG |
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1841 |
AGCATTCTTT |
GTGGTTAAAT |
AAATTCTTAA |
ATCTGCCTAG |
TTTTGATGAA |
TTCTTTTGTG |
AAACTTGAAA |
GAGAATAGAC |
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1921 |
AGTATGACAT |
ATAGAATTAA |
TACAAAACAG |
TTTAACAACC |
ATTTAACTGC |
AGTGTAAGAA |
AATTGGACTG |
TAATCATATC |
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2001 |
GCTACTGGCA |
TCTGTTATCT |
AGTATGCATT |
TCTGGTGTGT |
ATCTGAAAGG |
AAGACATTTT |
CTACCCTAGA |
TCCAATTGCA |
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2081 |
TTTATTTATC |
AATAAGTGCC |
ATTAAATTGA |
AATTATATTA |
CATTTTACAC |
TTTCTCAATG |
AATGAACAAA |
TTAGTCTGTA |
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2161 |
GAATCTAGCC |
ACCTGTTTAG |
CCTAGTCATG |
TGCCTTGAAC |
ATATATGTGT |
CCCATAATCT |
GGCTCATGGT |
ACCTGTTCTT |
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2241 |
CTATCCAAAC |
CTTTCAATTC |
ATGCTACCTG |
ATTCATTTAT |
TTGACATAGA |
TCTTAGGCCC |
ACTTGAACTC |
TTTTCTTGTT |
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2321 |
TATCTAGCAT |
AGCACAAACG |
TTTTTCCAGT |
CTTCTTTATC |
AACACTAATG |
CCTCTTAATT |
GCATCAGTAT |
TTCCTATTGG |
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2401 |
AAAATACATC |
TGTTCCAGAA |
AAACATTTGG |
CATTCCTGAA |
TAATTTCCAA |
ATGTTTTTAA |
TCCAAAGAAA |
AAGGTTTAAA |
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2481 |
GCTTATTTCC |
CTTTCTTATA |
CACACCTGAA |
TAAAATTGAT |
GTGCATGTTT |
TAGGGATCAA |
TTACCTAACT |
GTTCCTTGGT |
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2561 |
CTATTTATGT |
ATAAGAATGC |
TTTTTAAAGC |
ACATGTCTCA |
TTTTAAATGA |
CGCACAAACT |
GAAGATGTTA |
ATAAAATTTA |
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2641 |
AGAGTAATAC |
AATGAAAAAA |
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>gi|223468572|ref|NM_005638.4|Vesicle-associated membrane protein 7 (VAMP7), transcript variant 1
GAGGAGCGCTCCCACTCCCAAGAGGCCACGCGTAGACGGGGCGCTTCATGCGGAAGTCAGCGGCGTCCGGTCCCAGCCTC
CTCTGGGAGCGGGCAGTTGGCGACCCTGCACTGACCCGCGTCCCTCCGTCCCGAGCCCGCGCGCCCTCAGAGGGTGCCCG
GACAGACTGAAGCCATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGA
GGAAACTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAATAACAAACTAACGTACTCACATGGCAA
TTATTTGTTTCATTACATCTGCCAAGACAGGATTGTATATCTTTGTATCACTGATGATGATTTTGAACGTTCCCGAGCCT
TTAATTTTCTGAATGAGATAAAGAAGAGGTTCCAGACTACTTACGGTTCAAGAGCACAGACAGCACTTCCATATGCCATG
AATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTGAAGCATCACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGAC
TCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAACATAGATCTGGTAGCTCAGCGAGGAGAAAGATTGGAAT
TATTGATTGACAAAACAGAAAATCTTGTGGATTCTTCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATG
TGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATTGTGTTCATCTATATCATTGTTTCACCTCTCTG
TGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAGGAAAGAAGAAGTTACCATTAACCAAGGATATGAGAGAACAAGG
AGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGACAGATGGTATCTGCCAGTCTCTTCAACCCTCTTCTCAC
TTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTTATCTACCAGTTTATTCCTGTGAACTTCAGATTGAACC
ATTCATTGCAGCAGTAGCCTTAAAAAGGCTTTTGTTTATTTCTTTGGTTTGTTAACTAGTGTCATCTATTTAGAGAAACA
TTTTTGTTTTTAATTGCTCAAAGCTGTCGCCGCTAGTCTTATGAGCTATCTACTAAAACTATGGAGAAACTTTGTATGTG
CACACAAAAGTATTCAAGAGACAGTATTGCTAACATCTCATCTTAATGTCTTTTGTTATTGAGAAGTTTTAGGTGCTTCA
AAACAATATAAATGGATAATAGTTGTTATTTGGGGAATTGTAATGATGTTGGTGCTGCTTCCTTCTAAGAGCTCAGACAA
GTAAAGTATGAAACATTCTTATTTCAGTTAGATGGGGAACATTTTGCTAGCCCATTAGAAGCACACAGAATTATCCTTGT
CCTCCTAATATTGACTTTCAGGAATAAAGTTCAGTGTGCTGATCATTCACAATACAGTGGATAGCTTGATATCTTCTGTT
TTCCCATTGCAGTTGATTTGAGAAGATGAAGGTTTAAATATTGTTGAAAGTTGCAGTTTTTTAAATGTGTTCCTTTTTCT
TCTGTGAATATTTAGGGCAATCGTGTCGCTAATAGAATATGTAGTAGAGGGGGTGGGGAGGTAAATTCCTCTGACTTGCC
AAAGAAAAAGAAGGGAACCACAGTGGATATGCTAGCATTTTAGCTGTGCAAAGGGAGGTAGTGTGGGAAAAGTGTTTCCA
TTCTGGGAAAAGCCCAAACCGAATACGGTCAGCAGTCAACTCCAGGGTTTGGGCTTGATTCCTGTTGAATAATAGTTTTG
AGCATTCTTTGTGGTTAAATAAATTCTTAAATCTGCCTAGTTTTGATGAATTCTTTTGTGAAACTTGAAAGAGAATAGAC
AGTATGACATATAGAATTAATACAAAACAGTTTAACAACCATTTAACTGCAGTGTAAGAAAATTGGACTGTAATCATATC
GCTACTGGCATCTGTTATCTAGTATGCATTTCTGGTGTGTATCTGAAAGGAAGACATTTTCTACCCTAGATCCAATTGCA
TTTATTTATCAATAAGTGCCATTAAATTGAAATTATATTACATTTTACACTTTCTCAATGAATGAACAAATTAGTCTGTA
GAATCTAGCCACCTGTTTAGCCTAGTCATGTGCCTTGAACATATATGTGTCCCATAATCTGGCTCATGGTACCTGTTCTT
CTATCCAAACCTTTCAATTCATGCTACCTGATTCATTTATTTGACATAGATCTTAGGCCCACTTGAACTCTTTTCTTGTT
TATCTAGCATAGCACAAACGTTTTTCCAGTCTTCTTTATCAACACTAATGCCTCTTAATTGCATCAGTATTTCCTATTGG
AAAATACATCTGTTCCAGAAAAACATTTGGCATTCCTGAATAATTTCCAAATGTTTTTAATCCAAAGAAAAAGGTTTAAA
GCTTATTTCCCTTTCTTATACACACCTGAATAAAATTGATGTGCATGTTTTAGGGATCAATTACCTAACTGTTCCTTGGT
CTATTTATGTATAAGAATGCTTTTTAAAGCACATGTCTCATTTTAAATGACGCACAAACTGAAGATGTTAATAAAATTTA
AGAGTAATACAATGAAAAAA
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Primary source |
RefSeq : NM_001145149.1 (GI:223468573)
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Name |
Vesicle-associated membrane protein 7 (VAMP7), transcript variant 2
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
2537 nt
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Map |
Xq28 and Yq12
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Location |
Chromosome X (NC_000023.10) strand : +
155110946...155111110 | 155119120...155119209 | 155127775...155127912 | 155130160...155130250 |
155149476...155149543 | 155169364...155169456 | 155171546...155173432 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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165
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165
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1
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Exon 2a
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166
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255
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90
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1
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Exon 4
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256
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393
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138
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1
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Exon 5
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394
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484
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91
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1
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Exon 6
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485
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552
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68
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1
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Exon 7
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553
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645
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93
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1
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Exon 8
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646
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2532
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1887
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1
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ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
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Primary source |
NCBI : CCDS48199
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Nucleotide |
VAMP7, mRNA isoform 2[NM_001145149.1] : 175...714
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Length |
540
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Location |
Chromosome X (NC_000023.10) strand : +
155119129...155119209 | 155127775...155127912 | 155130160...155130250 | 155149476...155149543 |
155169364...155169456 | 155171546...155171614 |
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Start codon |
1
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Translation |
NP_001138621.1 |
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1 |
GAGGAGCGCT |
CCCACTCCCA |
AGAGGCCACG |
CGTAGACGGG |
GCGCTTCATG |
CGGAAGTCAG |
CGGCGTCCGG |
TCCCAGCCTC |
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81 |
CTCTGGGAGC |
GGGCAGTTGG |
CGACCCTGCA |
CTGACCCGCG |
TCCCTCCGTC |
CCGAGCCCGC |
GCGCCCTCAG |
AGGGTGCCCG |
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161 |
GACAGACTGA |
AGCCATGGCG |
ATTCTTTTTG |
CTGTTGTTGC |
CAGGGGGACC |
ACTATCCTTG |
CCAAACATGC |
TTGGTGTGGA |
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241 |
GGAAACTTCC |
TGGAGGATTT |
TGAACGTTCC |
CGAGCCTTTA |
ATTTTCTGAA |
TGAGATAAAG |
AAGAGGTTCC |
AGACTACTTA |
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321 |
CGGTTCAAGA |
GCACAGACAG |
CACTTCCATA |
TGCCATGAAT |
AGCGAGTTCT |
CAAGTGTCTT |
AGCTGCACAG |
CTGAAGCATC |
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401 |
ACTCTGAGAA |
TAAGGGCCTA |
GACAAAGTGA |
TGGAGACTCA |
AGCCCAAGTG |
GATGAACTGA |
AAGGAATCAT |
GGTCAGAAAC |
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481 |
ATAGATCTGG |
TAGCTCAGCG |
AGGAGAAAGA |
TTGGAATTAT |
TGATTGACAA |
AACAGAAAAT |
CTTGTGGATT |
CTTCTGTCAC |
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561 |
CTTCAAAACT |
ACCAGCAGAA |
ATCTTGCTCG |
AGCCATGTGT |
ATGAAGAACC |
TCAAGCTCAC |
TATTATCATC |
ATCATCGTAT |
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641 |
CAATTGTGTT |
CATCTATATC |
ATTGTTTCAC |
CTCTCTGTGG |
TGGATTTACA |
TGGCCAAGCT |
GTGTGAAGAA |
ATAGGAAAGA |
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721 |
AGAAGTTACC |
ATTAACCAAG |
GATATGAGAG |
AACAAGGAGT |
TAAAAGCAAT |
CCATGTGACT |
CAAGCCTTTC |
ACATACTGAC |
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801 |
AGATGGTATC |
TGCCAGTCTC |
TTCAACCCTC |
TTCTCACTTT |
TTAAAATCTT |
GTTCCATGCC |
TCCAGGTTTA |
TCTTTGTCTT |
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881 |
ATCTACCAGT |
TTATTCCTGT |
GAACTTCAGA |
TTGAACCATT |
CATTGCAGCA |
GTAGCCTTAA |
AAAGGCTTTT |
GTTTATTTCT |
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961 |
TTGGTTTGTT |
AACTAGTGTC |
ATCTATTTAG |
AGAAACATTT |
TTGTTTTTAA |
TTGCTCAAAG |
CTGTCGCCGC |
TAGTCTTATG |
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1041 |
AGCTATCTAC |
TAAAACTATG |
GAGAAACTTT |
GTATGTGCAC |
ACAAAAGTAT |
TCAAGAGACA |
GTATTGCTAA |
CATCTCATCT |
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1121 |
TAATGTCTTT |
TGTTATTGAG |
AAGTTTTAGG |
TGCTTCAAAA |
CAATATAAAT |
GGATAATAGT |
TGTTATTTGG |
GGAATTGTAA |
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1201 |
TGATGTTGGT |
GCTGCTTCCT |
TCTAAGAGCT |
CAGACAAGTA |
AAGTATGAAA |
CATTCTTATT |
TCAGTTAGAT |
GGGGAACATT |
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1281 |
TTGCTAGCCC |
ATTAGAAGCA |
CACAGAATTA |
TCCTTGTCCT |
CCTAATATTG |
ACTTTCAGGA |
ATAAAGTTCA |
GTGTGCTGAT |
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1361 |
CATTCACAAT |
ACAGTGGATA |
GCTTGATATC |
TTCTGTTTTC |
CCATTGCAGT |
TGATTTGAGA |
AGATGAAGGT |
TTAAATATTG |
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1441 |
TTGAAAGTTG |
CAGTTTTTTA |
AATGTGTTCC |
TTTTTCTTCT |
GTGAATATTT |
AGGGCAATCG |
TGTCGCTAAT |
AGAATATGTA |
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1521 |
GTAGAGGGGG |
TGGGGAGGTA |
AATTCCTCTG |
ACTTGCCAAA |
GAAAAAGAAG |
GGAACCACAG |
TGGATATGCT |
AGCATTTTAG |
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1601 |
CTGTGCAAAG |
GGAGGTAGTG |
TGGGAAAAGT |
GTTTCCATTC |
TGGGAAAAGC |
CCAAACCGAA |
TACGGTCAGC |
AGTCAACTCC |
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1681 |
AGGGTTTGGG |
CTTGATTCCT |
GTTGAATAAT |
AGTTTTGAGC |
ATTCTTTGTG |
GTTAAATAAA |
TTCTTAAATC |
TGCCTAGTTT |
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1761 |
TGATGAATTC |
TTTTGTGAAA |
CTTGAAAGAG |
AATAGACAGT |
ATGACATATA |
GAATTAATAC |
AAAACAGTTT |
AACAACCATT |
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1841 |
TAACTGCAGT |
GTAAGAAAAT |
TGGACTGTAA |
TCATATCGCT |
ACTGGCATCT |
GTTATCTAGT |
ATGCATTTCT |
GGTGTGTATC |
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1921 |
TGAAAGGAAG |
ACATTTTCTA |
CCCTAGATCC |
AATTGCATTT |
ATTTATCAAT |
AAGTGCCATT |
AAATTGAAAT |
TATATTACAT |
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2001 |
TTTACACTTT |
CTCAATGAAT |
GAACAAATTA |
GTCTGTAGAA |
TCTAGCCACC |
TGTTTAGCCT |
AGTCATGTGC |
CTTGAACATA |
|
2081 |
TATGTGTCCC |
ATAATCTGGC |
TCATGGTACC |
TGTTCTTCTA |
TCCAAACCTT |
TCAATTCATG |
CTACCTGATT |
CATTTATTTG |
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2161 |
ACATAGATCT |
TAGGCCCACT |
TGAACTCTTT |
TCTTGTTTAT |
CTAGCATAGC |
ACAAACGTTT |
TTCCAGTCTT |
CTTTATCAAC |
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2241 |
ACTAATGCCT |
CTTAATTGCA |
TCAGTATTTC |
CTATTGGAAA |
ATACATCTGT |
TCCAGAAAAA |
CATTTGGCAT |
TCCTGAATAA |
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2321 |
TTTCCAAATG |
TTTTTAATCC |
AAAGAAAAAG |
GTTTAAAGCT |
TATTTCCCTT |
TCTTATACAC |
ACCTGAATAA |
AATTGATGTG |
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2401 |
CATGTTTTAG |
GGATCAATTA |
CCTAACTGTT |
CCTTGGTCTA |
TTTATGTATA |
AGAATGCTTT |
TTAAAGCACA |
TGTCTCATTT |
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2481 |
TAAATGACGC |
ACAAACTGAA |
GATGTTAATA |
AAATTTAAGA |
GTAATACAAT |
GAAAAAA |
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>gi|223468573|ref|NM_001145149.1|Vesicle-associated membrane protein 7 (VAMP7), transcript variant 2
GAGGAGCGCTCCCACTCCCAAGAGGCCACGCGTAGACGGGGCGCTTCATGCGGAAGTCAGCGGCGTCCGGTCCCAGCCTC
CTCTGGGAGCGGGCAGTTGGCGACCCTGCACTGACCCGCGTCCCTCCGTCCCGAGCCCGCGCGCCCTCAGAGGGTGCCCG
GACAGACTGAAGCCATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGA
GGAAACTTCCTGGAGGATTTTGAACGTTCCCGAGCCTTTAATTTTCTGAATGAGATAAAGAAGAGGTTCCAGACTACTTA
CGGTTCAAGAGCACAGACAGCACTTCCATATGCCATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTGAAGCATC
ACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAAC
ATAGATCTGGTAGCTCAGCGAGGAGAAAGATTGGAATTATTGATTGACAAAACAGAAAATCTTGTGGATTCTTCTGTCAC
CTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTAT
CAATTGTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAGGAAAGA
AGAAGTTACCATTAACCAAGGATATGAGAGAACAAGGAGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGAC
AGATGGTATCTGCCAGTCTCTTCAACCCTCTTCTCACTTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTT
ATCTACCAGTTTATTCCTGTGAACTTCAGATTGAACCATTCATTGCAGCAGTAGCCTTAAAAAGGCTTTTGTTTATTTCT
TTGGTTTGTTAACTAGTGTCATCTATTTAGAGAAACATTTTTGTTTTTAATTGCTCAAAGCTGTCGCCGCTAGTCTTATG
AGCTATCTACTAAAACTATGGAGAAACTTTGTATGTGCACACAAAAGTATTCAAGAGACAGTATTGCTAACATCTCATCT
TAATGTCTTTTGTTATTGAGAAGTTTTAGGTGCTTCAAAACAATATAAATGGATAATAGTTGTTATTTGGGGAATTGTAA
TGATGTTGGTGCTGCTTCCTTCTAAGAGCTCAGACAAGTAAAGTATGAAACATTCTTATTTCAGTTAGATGGGGAACATT
TTGCTAGCCCATTAGAAGCACACAGAATTATCCTTGTCCTCCTAATATTGACTTTCAGGAATAAAGTTCAGTGTGCTGAT
CATTCACAATACAGTGGATAGCTTGATATCTTCTGTTTTCCCATTGCAGTTGATTTGAGAAGATGAAGGTTTAAATATTG
TTGAAAGTTGCAGTTTTTTAAATGTGTTCCTTTTTCTTCTGTGAATATTTAGGGCAATCGTGTCGCTAATAGAATATGTA
GTAGAGGGGGTGGGGAGGTAAATTCCTCTGACTTGCCAAAGAAAAAGAAGGGAACCACAGTGGATATGCTAGCATTTTAG
CTGTGCAAAGGGAGGTAGTGTGGGAAAAGTGTTTCCATTCTGGGAAAAGCCCAAACCGAATACGGTCAGCAGTCAACTCC
AGGGTTTGGGCTTGATTCCTGTTGAATAATAGTTTTGAGCATTCTTTGTGGTTAAATAAATTCTTAAATCTGCCTAGTTT
TGATGAATTCTTTTGTGAAACTTGAAAGAGAATAGACAGTATGACATATAGAATTAATACAAAACAGTTTAACAACCATT
TAACTGCAGTGTAAGAAAATTGGACTGTAATCATATCGCTACTGGCATCTGTTATCTAGTATGCATTTCTGGTGTGTATC
TGAAAGGAAGACATTTTCTACCCTAGATCCAATTGCATTTATTTATCAATAAGTGCCATTAAATTGAAATTATATTACAT
TTTACACTTTCTCAATGAATGAACAAATTAGTCTGTAGAATCTAGCCACCTGTTTAGCCTAGTCATGTGCCTTGAACATA
TATGTGTCCCATAATCTGGCTCATGGTACCTGTTCTTCTATCCAAACCTTTCAATTCATGCTACCTGATTCATTTATTTG
ACATAGATCTTAGGCCCACTTGAACTCTTTTCTTGTTTATCTAGCATAGCACAAACGTTTTTCCAGTCTTCTTTATCAAC
ACTAATGCCTCTTAATTGCATCAGTATTTCCTATTGGAAAATACATCTGTTCCAGAAAAACATTTGGCATTCCTGAATAA
TTTCCAAATGTTTTTAATCCAAAGAAAAAGGTTTAAAGCTTATTTCCCTTTCTTATACACACCTGAATAAAATTGATGTG
CATGTTTTAGGGATCAATTACCTAACTGTTCCTTGGTCTATTTATGTATAAGAATGCTTTTTAAAGCACATGTCTCATTT
TAAATGACGCACAAACTGAAGATGTTAATAAAATTTAAGAGTAATACAATGAAAAAA
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Exon number |
2b
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Length |
155 nt
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Location |
Chromosome X (NC_000023.10) : 155119120...155119274 (+)
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Is part of |
VAMP7, mRNA isoform 1
(NM_005638.4)
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Sequence |
Show
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ACTGAAGCCATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGAGGAAA
CTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAATAACAAACTAACGTACTCACATGGCAA
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Exon number |
8
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Length |
1887 nt
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Location |
Chromosome X (NC_000023.10) : 155171546...155173432 (+)
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Is part of |
VAMP7, mRNA isoform 2
(NM_001145149.1)
VAMP7, mRNA isoform 1
(NM_005638.4)
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Sequence |
Show
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GTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAGGAAAGAAGAAG
TTACCATTAACCAAGGATATGAGAGAACAAGGAGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGACAGATG
GTATCTGCCAGTCTCTTCAACCCTCTTCTCACTTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTTATCTA
CCAGTTTATTCCTGTGAACTTCAGATTGAACCATTCATTGCAGCAGTAGCCTTAAAAAGGCTTTTGTTTATTTCTTTGGT
TTGTTAACTAGTGTCATCTATTTAGAGAAACATTTTTGTTTTTAATTGCTCAAAGCTGTCGCCGCTAGTCTTATGAGCTA
TCTACTAAAACTATGGAGAAACTTTGTATGTGCACACAAAAGTATTCAAGAGACAGTATTGCTAACATCTCATCTTAATG
TCTTTTGTTATTGAGAAGTTTTAGGTGCTTCAAAACAATATAAATGGATAATAGTTGTTATTTGGGGAATTGTAATGATG
TTGGTGCTGCTTCCTTCTAAGAGCTCAGACAAGTAAAGTATGAAACATTCTTATTTCAGTTAGATGGGGAACATTTTGCT
AGCCCATTAGAAGCACACAGAATTATCCTTGTCCTCCTAATATTGACTTTCAGGAATAAAGTTCAGTGTGCTGATCATTC
ACAATACAGTGGATAGCTTGATATCTTCTGTTTTCCCATTGCAGTTGATTTGAGAAGATGAAGGTTTAAATATTGTTGAA
AGTTGCAGTTTTTTAAATGTGTTCCTTTTTCTTCTGTGAATATTTAGGGCAATCGTGTCGCTAATAGAATATGTAGTAGA
GGGGGTGGGGAGGTAAATTCCTCTGACTTGCCAAAGAAAAAGAAGGGAACCACAGTGGATATGCTAGCATTTTAGCTGTG
CAAAGGGAGGTAGTGTGGGAAAAGTGTTTCCATTCTGGGAAAAGCCCAAACCGAATACGGTCAGCAGTCAACTCCAGGGT
TTGGGCTTGATTCCTGTTGAATAATAGTTTTGAGCATTCTTTGTGGTTAAATAAATTCTTAAATCTGCCTAGTTTTGATG
AATTCTTTTGTGAAACTTGAAAGAGAATAGACAGTATGACATATAGAATTAATACAAAACAGTTTAACAACCATTTAACT
GCAGTGTAAGAAAATTGGACTGTAATCATATCGCTACTGGCATCTGTTATCTAGTATGCATTTCTGGTGTGTATCTGAAA
GGAAGACATTTTCTACCCTAGATCCAATTGCATTTATTTATCAATAAGTGCCATTAAATTGAAATTATATTACATTTTAC
ACTTTCTCAATGAATGAACAAATTAGTCTGTAGAATCTAGCCACCTGTTTAGCCTAGTCATGTGCCTTGAACATATATGT
GTCCCATAATCTGGCTCATGGTACCTGTTCTTCTATCCAAACCTTTCAATTCATGCTACCTGATTCATTTATTTGACATA
GATCTTAGGCCCACTTGAACTCTTTTCTTGTTTATCTAGCATAGCACAAACGTTTTTCCAGTCTTCTTTATCAACACTAA
TGCCTCTTAATTGCATCAGTATTTCCTATTGGAAAATACATCTGTTCCAGAAAAACATTTGGCATTCCTGAATAATTTCC
AAATGTTTTTAATCCAAAGAAAAAGGTTTAAAGCTTATTTCCCTTTCTTATACACACCTGAATAAAATTGATGTGCATGT
TTTAGGGATCAATTACCTAACTGTTCCTTGGTCTATTTATGTATAAGAATGCTTTTTAAAGCACATGTCTCATTTTAAAT
GACGCACAAACTGAAGATGTTAATAAAATTTAAGAGTAATACAATGA
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Primary source |
Uniprot : P51809
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Name |
Vesicle-associated membrane protein 7
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Alternative name(s) |
Synaptobrevin-like protein 1 Tetanus-insensitive VAMP
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Synonym(s) |
Ti-VAMP VAMP-7
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Organism |
Homo sapiens
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Length |
220 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Function
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Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
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Similarity
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Belongs to the synaptobrevin family.
Contains 1 longin domain.
Contains 1 v-SNARE coiled-coil homology domain.
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Subcellular location
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Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (By similarity). Late endosome membrane; Single- pass type IV membrane protein (By similarity). Lysosome membrane; Single-pass type IV membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein (By similarity).
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Subunit
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Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells (By similarity).
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Tissue specificity
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Detected in all tissues tested.
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Biological process
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ER to Golgi vesicle-mediated transport [GO:0006888]
post-Golgi vesicle-mediated transport [GO:0006892]
vesicle fusion [GO:0006906]
phagocytosis, engulfment [GO:0006911]
endosome to lysosome transport [GO:0008333]
protein transport [GO:0015031]
calcium ion-dependent exocytosis [GO:0017156]
eosinophil degranulation [GO:0043308]
neutrophil degranulation [GO:0043312]
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Cellular component
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lysosomal membrane [GO:0005765]
endoplasmic reticulum membrane [GO:0005789]
Golgi apparatus [GO:0005794]
integral to membrane [GO:0016021]
transport vesicle membrane [GO:0030658]
phagocytic vesicle membrane [GO:0030670]
SNARE complex [GO:0031201]
late endosome membrane [GO:0031902]
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Molecular function
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protein binding [GO:0005515]
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Alternative product(s)
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top
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  |
Uniprot Identifier
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Difference(s) with the 'canonical' sequence
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Notes
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Sequences
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Isoform 1
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P51809-1
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---
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'Canonical' sequence
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Get Fasta
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Isoform 2
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P51809-2
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145-220 : DLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMK NLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK -> VC HLQNYQQKSCSSHVYEEPQAHYYHHHRINCVHLYHCFTSLW WIYMAKLCEEIGKKKLPLTKDMREQGVKSNPCDSSLSHTDR WYLPVSSTLFSLFKILFHASRFIFVLSTSLFL
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---
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Get Fasta
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Isoform 3
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P51809-3
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28-68 : Missing
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---
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Get Fasta
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Feature key |
Position
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Length
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Description
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Feature identifier
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Molecule processing |
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Initiator methionine
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1 - 1
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1
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Removed
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P51809-INIT_MET-1
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Region |
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Domain
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7 - 110
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104
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Longin
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P51809-DOMAIN-7
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Domain
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125 - 185
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61
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v-SNARE coiled-coil homology
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P51809-DOMAIN-125
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Topological domain
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2 - 188
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187
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Cytoplasmic (Potential)
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P51809-TOPO_DOM-2
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Topological domain
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210 - 220
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11
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Vesicular (Potential)
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P51809-TOPO_DOM-210
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Transmembrane
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189 - 209
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21
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Helical; Anchor for type IV membrane protein; (Potential)
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P51809-TRANSMEM-189
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Natural variations |
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Alternative sequence
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28 - 68
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41
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Missing
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VSP_017508
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Alternative sequence
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145 - 220
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76
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DLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMK NLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK -> VC HLQNYQQKSCSSHVYEEPQAHYYHHHRINCVHLYHCFTSLW WIYMAKLCEEIGKKKLPLTKDMREQGVKSNPCDSSLSHTDR WYLPVSSTLFSLFKILFHASRFIFVLSTSLFL
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VSP_017509
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Amino acid modifications |
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Modified residue
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2 - 2
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1
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N-acetylalanine; partial
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P51809-MOD_RES-2
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Modified residue
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168 - 168
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1
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Phosphoserine
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P51809-MOD_RES-168
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1 |
MAILFAVVAR |
GTTILAKHAW |
CGGNFLEVTE |
QILAKIPSEN |
NKLTYSHGNY |
LFHYICQDRI |
VYLCITDDDF |
ERSRAFNFLN |
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81 |
EIKKRFQTTY |
GSRAQTALPY |
AMNSEFSSVL |
AAQLKHHSEN |
KGLDKVMETQ |
AQVDELKGIM |
VRNIDLVAQR |
GERLELLIDK |
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161 |
TENLVDSSVT |
FKTTSRNLAR |
AMCMKNLKLT |
IIIIIVSIVF |
IYIIVSPLCG |
GFTWPSCVKK |
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>sp|P51809|VAMP7_human Vesicle-associated membrane protein 7
MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLN
EIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDK
TENLVDSSVTFKTTSRNLARAMCMKNLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCVKK
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