(CXCR4) chemokine (C-X-C motif) receptor 4 [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  1830
 Official symbol  CXCR4
 Official name  chemokine (C-X-C motif) receptor 4
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 2 (NC_000002.11) :  136871918...136875724  (-)
 Map  2q21
 Length  3807  nt
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Alternative name(s) and Synynom(s) top
Synonyms WHIM; NPYRL; LCR1; LAP3; FB22; NPYY3R; NPYR; NPY3R; LESTR; HSY3RR; HM89; fusin; D2S201E; CD184
Alternative name(s) seven transmembrane helix receptor; C-X-C chemokine receptor type 4; CD184 antigen; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven-transmembrane-domain receptor; fusin; neuropeptide Y receptor Y3; chemokine (C-X-C motif), receptor 4 (fusin)
External Links top
Ensembl ENSG00000121966
Entrez 7852
HGNC 2561
HPRD 01217
Comment top
Summary This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
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Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
ACTTCAGTTT GTTGGCTGCG GCAGCAGGTA GCAAAGTGAC GCCGAGGGCC TGAGTGCTCC AGTAGCCACC GCATCTGGAG
81  AACCAGCGGT TACCATGGAG GGGATCAGTG TAAGTCCAGT TTCAACCTGC TTTGTCATAA ATGTACAAAC GTTTGAACTT
161  AGAGCGCAGC CCCTCTCCGA GCGGGCAGAA GCGGCCAGGA CATTGGAGGT ACCCGTACTC CAAAAAAGGG TCACCGAAAG
241  GAGTTTTCTT GACCATGCCT ATATAGTGCG GGTGGGTGGG GGGGGAGCAG GATTGGAATC TTTTTCTCTG TGAGTCGAGG
321  AGAAACGACT GGAAAGAGCG TTCCAGTGGC TGCATGTGTC TCCCCCTTGA GTCCCGCCGC GCGCGGCGGC TTGCACGCTG
401  TTTGCAAACG TAAGAACATT CTGTGCACAA GTGCAGAGAA GGCGTGCGCG CTGCCTCGGG ACTCAGACCA CCGGTCTCTT
481  CCTTGGGGAA GCGGGGATGT CTTGGAGCGA GTTACATTGT CTGAATTTAG AGGCGGAGGG CGGCGTGCCT GGGCTGAGTT
561  CCCAGGAGGA GATTGCGCCC GCTTTAACTT CGGGGTTAAG CGCCTGGTGA CTGTTCTTGA CACTGGGTGC GTGTTTGTTA
641  AACTCTGTGC GGCCGACGGA GCTGTGCCAG TCTCCCAGCA CAGTAGGCAG AGGGCGGGAG AGGCGGGTGG ACCCACCGCG
721  CCGATCCTCT GAGGGGATCG AGTGGTGGCA GCAGCTAGGA GTTGATCCGC CCGCGCGCTT TGGGTTTGAG GGGGAAAACC
801  TTCCCGCCGT CCGAAGCGCG CCTCTTCCCC ACGGCCGCGA GTGGGTCCTG CAGTTCGAGA GTTTGGGGTC GTGCAGAGGT
881  CAGCGGAGTG GTTTGACCTC CCCTTTGACA CCGCGCAGCT GCCAGCCCTG AGATTTGCGC TCCGGGGATA GGAGCGGGTA
961  CGGGGTGAGG GGCGGGGGCG GTTAAGACCG CACCTGGGCT GCCAGGTCGC CGCCGCGAAG ACTGGCAGGT GCAAGTGGGG
1041  AAACCGTTTG GCTCTCTCCG AGTCCAGTTG TGATGTTTAA CCGTCGGTGG TTTCCAGAAA CCTTTTGAAA CCCTCTTGCT
1121  AGGGAGTTTT TGGTTTCCTG CAGCGGCGCG CAATTCAAAG ACGCTCGCGG CGGAGCCGCC CAGTCGCTCC CCAGCACCCT
1201  GTGGGACAGA GCCTGGCGTG TCGCCCAGCG GAGCCCCTGC AGCGCTGCTT GCGGGCGGTT GGCGTGGGTG TAGTGGGCAG
1281  CCGCGGCGGC CCGGGGCTGG ACGACCCGGC CCCCCGCGTG CCCACCGCCT GGAGGCTTCC AGCTGCCCAC CTCCGGCCGG
1361  GTTAACTGGA TCAGTGGCGG GGTAATGGGA AGCCACCCGG GAGAGTGAGG AAATGAAACT TGGGGCGAGG ACCACGGGTG
1441  CAGACCCCGT TACCTTCTCC ACCCAGGAAA ATGCCCCGCT CCCTAACGTC CCAAACGCGC CAAGTGATAA ACACGAGGAT
1521  GGCAAGAGAC CCACACACCG GAGGAGCGCC CGCTTGGGGG AGGAGGTGCC GTTTGTTCAT TTTCTGACAC TCCCGCCCAA
1601  TATACCCCAA GCACCGAAGG GCCTTCGTTT TAAGACCGCA TTCTCTTTAC CCACTACAAG TTGCTTGAAG CCCAGAATGG
1681  TTTGTATTTA GGCAGGCGTG GGAAAATTAA GTTTTTGCGC TTTAGGAGAA TGAGTCTTTG CAACGCCCCC GCCCTCCCCC
1761  CGTGATCCTC CCTTCTCCCC TCTTCCCTCC CTGGGCGAAA AACTTCTTAC AAAAAGTTAA TCACTGCCCC TCCTAGCAGC
1841  ACCCACCCCA CCCCCCACGC CGCCTGGGAG TGGCCTCTTT GTGTGTATTT TTTTTTTCCT CCTAAGGAAG GTTTTTTTTC
1921  TTCCCTCTAG TGGGCGGGGC AGAGGAGTTA GCCAAGATGT GACTTTGAAA CCCTCAGCGT CTCAGTGCCC TTTTGTTCTA
2001  AACAAAGAAT TTTGTAATTG GTTCTACCAA AGAAGGATAT AATGAAGTCA CTATGGGAAA AGATGGGGAG GAGAGTTGTA
2081  GGATTCTACA TTAATTCTCT TGTGCCCTTA GCCCACTACT TCAGAATTTC CTGAAGAAAG CAAGCCTGAA TTGGTTTTTT
2161  AAATTGCTTT AAAAATTTTT TTTAACTGGG TTAATGCTTG CTGAATTGGA AGTGAATGTC CATTCCTTTG CCTCTTTTGC
2241  AGATATACAC TTCAGATAAC TACACCGAGG AAATGGGCTC AGGGGACTAT GACTCCATGA AGGAACCCTG TTTCCGTGAA
2321  GAAAATGCTA ATTTCAATAA AATCTTCCTG CCCACCATCT ACTCCATCAT CTTCTTAACT GGCATTGTGG GCAATGGATT
2401  GGTCATCCTG GTCATGGGTT ACCAGAAGAA ACTGAGAAGC ATGACGGACA AGTACAGGCT GCACCTGTCA GTGGCCGACC
2481  TCCTCTTTGT CATCACGCTT CCCTTCTGGG CAGTTGATGC CGTGGCAAAC TGGTACTTTG GGAACTTCCT ATGCAAGGCA
2561  GTCCATGTCA TCTACACAGT CAACCTCTAC AGCAGTGTCC TCATCCTGGC CTTCATCAGT CTGGACCGCT ACCTGGCCAT
2641  CGTCCACGCC ACCAACAGTC AGAGGCCAAG GAAGCTGTTG GCTGAAAAGG TGGTCTATGT TGGCGTCTGG ATCCCTGCCC
2721  TCCTGCTGAC TATTCCCGAC TTCATCTTTG CCAACGTCAG TGAGGCAGAT GACAGATATA TCTGTGACCG CTTCTACCCC
2801  AATGACTTGT GGGTGGTTGT GTTCCAGTTT CAGCACATCA TGGTTGGCCT TATCCTGCCT GGTATTGTCA TCCTGTCCTG
2881  CTATTGCATT ATCATCTCCA AGCTGTCACA CTCCAAGGGC CACCAGAAGC GCAAGGCCCT CAAGACCACA GTCATCCTCA
2961  TCCTGGCTTT CTTCGCCTGT TGGCTGCCTT ACTACATTGG GATCAGCATC GACTCCTTCA TCCTCCTGGA AATCATCAAG
3041  CAAGGGTGTG AGTTTGAGAA CACTGTGCAC AAGTGGATTT CCATCACCGA GGCCCTAGCT TTCTTCCACT GTTGTCTGAA
3121  CCCCATCCTC TATGCTTTCC TTGGAGCCAA ATTTAAAACC TCTGCCCAGC ACGCACTCAC CTCTGTGAGC AGAGGGTCCA
3201  GCCTCAAGAT CCTCTCCAAA GGAAAGCGAG GTGGACATTC ATCTGTTTCC ACTGAGTCTG AGTCTTCAAG TTTTCACTCC
3281  AGCTAACACA GATGTAAAAG ACTTTTTTTT ATACGATAAA TAACTTTTTT TTAAGTTACA CATTTTTCAG ATATAAAAGA
3361  CTGACCAATA TTGTACAGTT TTTATTGCTT GTTGGATTTT TGTCTTGTGT TTCTTTAGTT TTTGTGAAGT TTAATTGACT
3441  TATTTATATA AATTTTTTTT GTTTCATATT GATGTGTGTC TAGGCAGGAC CTGTGGCCAA GTTCTTAGTT GCTGTATGTC
3521  TCGTGGTAGG ACTGTAGAAA AGGGAACTGA ACATTCCAGA GCGTGTAGTG AATCACGTAA AGCTAGAAAT GATCCCCAGC
3601  TGTTTATGCA TAGATAATCT CTCCATTCCC GTGGAACGTT TTTCCTGTTC TTAAGACGTG ATTTTGCTGT AGAAGATGGC
3681  ACTTATAACC AAAGCCCAAA GTGGTATAGA AATGCTGGTT TTTCAGTTTT CAGGAGTGGG TTGATTTCAG CACCTACAGT
3761  GTACAGTCTT GTATTAAGTT GTTAATAAAA GTACATGTTA AACTTAC
>ref|Gene_ID:7852|CXCR4|NC_000002.11:136871918...136875724 (-)
ACTTCAGTTTGTTGGCTGCGGCAGCAGGTAGCAAAGTGACGCCGAGGGCCTGAGTGCTCCAGTAGCCACCGCATCTGGAG
AACCAGCGGTTACCATGGAGGGGATCAGTGTAAGTCCAGTTTCAACCTGCTTTGTCATAAATGTACAAACGTTTGAACTT
AGAGCGCAGCCCCTCTCCGAGCGGGCAGAAGCGGCCAGGACATTGGAGGTACCCGTACTCCAAAAAAGGGTCACCGAAAG
GAGTTTTCTTGACCATGCCTATATAGTGCGGGTGGGTGGGGGGGGAGCAGGATTGGAATCTTTTTCTCTGTGAGTCGAGG
AGAAACGACTGGAAAGAGCGTTCCAGTGGCTGCATGTGTCTCCCCCTTGAGTCCCGCCGCGCGCGGCGGCTTGCACGCTG
TTTGCAAACGTAAGAACATTCTGTGCACAAGTGCAGAGAAGGCGTGCGCGCTGCCTCGGGACTCAGACCACCGGTCTCTT
CCTTGGGGAAGCGGGGATGTCTTGGAGCGAGTTACATTGTCTGAATTTAGAGGCGGAGGGCGGCGTGCCTGGGCTGAGTT
CCCAGGAGGAGATTGCGCCCGCTTTAACTTCGGGGTTAAGCGCCTGGTGACTGTTCTTGACACTGGGTGCGTGTTTGTTA
AACTCTGTGCGGCCGACGGAGCTGTGCCAGTCTCCCAGCACAGTAGGCAGAGGGCGGGAGAGGCGGGTGGACCCACCGCG
CCGATCCTCTGAGGGGATCGAGTGGTGGCAGCAGCTAGGAGTTGATCCGCCCGCGCGCTTTGGGTTTGAGGGGGAAAACC
TTCCCGCCGTCCGAAGCGCGCCTCTTCCCCACGGCCGCGAGTGGGTCCTGCAGTTCGAGAGTTTGGGGTCGTGCAGAGGT
CAGCGGAGTGGTTTGACCTCCCCTTTGACACCGCGCAGCTGCCAGCCCTGAGATTTGCGCTCCGGGGATAGGAGCGGGTA
CGGGGTGAGGGGCGGGGGCGGTTAAGACCGCACCTGGGCTGCCAGGTCGCCGCCGCGAAGACTGGCAGGTGCAAGTGGGG
AAACCGTTTGGCTCTCTCCGAGTCCAGTTGTGATGTTTAACCGTCGGTGGTTTCCAGAAACCTTTTGAAACCCTCTTGCT
AGGGAGTTTTTGGTTTCCTGCAGCGGCGCGCAATTCAAAGACGCTCGCGGCGGAGCCGCCCAGTCGCTCCCCAGCACCCT
GTGGGACAGAGCCTGGCGTGTCGCCCAGCGGAGCCCCTGCAGCGCTGCTTGCGGGCGGTTGGCGTGGGTGTAGTGGGCAG
CCGCGGCGGCCCGGGGCTGGACGACCCGGCCCCCCGCGTGCCCACCGCCTGGAGGCTTCCAGCTGCCCACCTCCGGCCGG
GTTAACTGGATCAGTGGCGGGGTAATGGGAAGCCACCCGGGAGAGTGAGGAAATGAAACTTGGGGCGAGGACCACGGGTG
CAGACCCCGTTACCTTCTCCACCCAGGAAAATGCCCCGCTCCCTAACGTCCCAAACGCGCCAAGTGATAAACACGAGGAT
GGCAAGAGACCCACACACCGGAGGAGCGCCCGCTTGGGGGAGGAGGTGCCGTTTGTTCATTTTCTGACACTCCCGCCCAA
TATACCCCAAGCACCGAAGGGCCTTCGTTTTAAGACCGCATTCTCTTTACCCACTACAAGTTGCTTGAAGCCCAGAATGG
TTTGTATTTAGGCAGGCGTGGGAAAATTAAGTTTTTGCGCTTTAGGAGAATGAGTCTTTGCAACGCCCCCGCCCTCCCCC
CGTGATCCTCCCTTCTCCCCTCTTCCCTCCCTGGGCGAAAAACTTCTTACAAAAAGTTAATCACTGCCCCTCCTAGCAGC
ACCCACCCCACCCCCCACGCCGCCTGGGAGTGGCCTCTTTGTGTGTATTTTTTTTTTCCTCCTAAGGAAGGTTTTTTTTC
TTCCCTCTAGTGGGCGGGGCAGAGGAGTTAGCCAAGATGTGACTTTGAAACCCTCAGCGTCTCAGTGCCCTTTTGTTCTA
AACAAAGAATTTTGTAATTGGTTCTACCAAAGAAGGATATAATGAAGTCACTATGGGAAAAGATGGGGAGGAGAGTTGTA
GGATTCTACATTAATTCTCTTGTGCCCTTAGCCCACTACTTCAGAATTTCCTGAAGAAAGCAAGCCTGAATTGGTTTTTT
AAATTGCTTTAAAAATTTTTTTTAACTGGGTTAATGCTTGCTGAATTGGAAGTGAATGTCCATTCCTTTGCCTCTTTTGC
AGATATACACTTCAGATAACTACACCGAGGAAATGGGCTCAGGGGACTATGACTCCATGAAGGAACCCTGTTTCCGTGAA
GAAAATGCTAATTTCAATAAAATCTTCCTGCCCACCATCTACTCCATCATCTTCTTAACTGGCATTGTGGGCAATGGATT
GGTCATCCTGGTCATGGGTTACCAGAAGAAACTGAGAAGCATGACGGACAAGTACAGGCTGCACCTGTCAGTGGCCGACC
TCCTCTTTGTCATCACGCTTCCCTTCTGGGCAGTTGATGCCGTGGCAAACTGGTACTTTGGGAACTTCCTATGCAAGGCA
GTCCATGTCATCTACACAGTCAACCTCTACAGCAGTGTCCTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTGGCCAT
CGTCCACGCCACCAACAGTCAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTCTATGTTGGCGTCTGGATCCCTGCCC
TCCTGCTGACTATTCCCGACTTCATCTTTGCCAACGTCAGTGAGGCAGATGACAGATATATCTGTGACCGCTTCTACCCC
AATGACTTGTGGGTGGTTGTGTTCCAGTTTCAGCACATCATGGTTGGCCTTATCCTGCCTGGTATTGTCATCCTGTCCTG
CTATTGCATTATCATCTCCAAGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAGGCCCTCAAGACCACAGTCATCCTCA
TCCTGGCTTTCTTCGCCTGTTGGCTGCCTTACTACATTGGGATCAGCATCGACTCCTTCATCCTCCTGGAAATCATCAAG
CAAGGGTGTGAGTTTGAGAACACTGTGCACAAGTGGATTTCCATCACCGAGGCCCTAGCTTTCTTCCACTGTTGTCTGAA
CCCCATCCTCTATGCTTTCCTTGGAGCCAAATTTAAAACCTCTGCCCAGCACGCACTCACCTCTGTGAGCAGAGGGTCCA
GCCTCAAGATCCTCTCCAAAGGAAAGCGAGGTGGACATTCATCTGTTTCCACTGAGTCTGAGTCTTCAAGTTTTCACTCC
AGCTAACACAGATGTAAAAGACTTTTTTTTATACGATAAATAACTTTTTTTTAAGTTACACATTTTTCAGATATAAAAGA
CTGACCAATATTGTACAGTTTTTATTGCTTGTTGGATTTTTGTCTTGTGTTTCTTTAGTTTTTGTGAAGTTTAATTGACT
TATTTATATAAATTTTTTTTGTTTCATATTGATGTGTGTCTAGGCAGGACCTGTGGCCAAGTTCTTAGTTGCTGTATGTC
TCGTGGTAGGACTGTAGAAAAGGGAACTGAACATTCCAGAGCGTGTAGTGAATCACGTAAAGCTAGAAATGATCCCCAGC
TGTTTATGCATAGATAATCTCTCCATTCCCGTGGAACGTTTTTCCTGTTCTTAAGACGTGATTTTGCTGTAGAAGATGGC
ACTTATAACCAAAGCCCAAAGTGGTATAGAAATGCTGGTTTTTCAGTTTTCAGGAGTGGGTTGATTTCAGCACCTACAGT
GTACAGTCTTGTATTAAGTTGTTAATAAAAGTACATGTTAAACTTAC