CASP1, mRNA isoform alpha - Generality top
	Primary source RefSeq : NM_033292.2 (GI:73622114) Name Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant alpha Type of transcript mRNA Organism Homo sapiens Length 1364 nt Map 11q23 Location Chromosome 11 (NC_000011.9)  strand : - 104896234...104896326   104896952...104897082   104897568...104897677   104899850...104899993   104900391...104900625   104901056...104901229   104901891...104902006   104903790...104903852   104904934...104905200   104905833...104905856
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 24 24 1 Exon 2b 25 291 267 1 Exon 3 292 354 63 1 Exon 4 355 470 116 1 Exon 5 471 644 174 1 Exon 6 645 879 235 1 Exon 7 880 1023 144 1 Exon 8 1024 1133 110 1 Exon 9 1134 1264 131 1 Exon 10 1265 1357 93 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source rs3016805 SNP 52 a/t 1 ? dbSNP rs56645262 SNP 61 a/g 1 ? dbSNP rs1042743 SNP 61 a/g 1 ? dbSNP rs3016711 SNP 71 c/t 1 ? dbSNP rs17103567 SNP 126 a/c 1 ? dbSNP rs61755275 SNP 126 a/c 1 ? dbSNP rs62640913 SNP 150 a/g 1 ? dbSNP rs61741841 SNP 177 c/t 1 ? dbSNP rs55646419 SNP 179 c/t 1 ? dbSNP rs539595 SNP 179 c/t 1 ? dbSNP rs12289229 SNP 206 a/g 1 ? dbSNP rs61741854 SNP 217 c/t 1 ? dbSNP rs61738278 SNP 260 a/c 1 ? dbSNP rs2509649 SNP 271 a/g 1 ? dbSNP rs61738279 SNP 284 a/g 1 ? dbSNP rs3203613 SNP 394 c/g 1 ? dbSNP rs3203614 SNP 399 a/g 1 ? dbSNP rs3203615 SNP 402 c/t 1 ? dbSNP rs3203616 SNP 427 c/t 1 ? dbSNP rs61755276 SNP 643 a/g 1 ? dbSNP rs45617533 SNP 736 a/g 1 ? dbSNP rs580253 SNP 783 c/t 1 ? dbSNP rs3737531 SNP 905 a/g 1 ? dbSNP rs61751523 SNP 973 a/g 1 ? dbSNP
	CDS top
	Primary source NCBI : CCDS8330 Nucleotide CASP1, mRNA isoform alpha[NM_033292.2] : 18...1232 Length 1215 Location Chromosome 11 (NC_000011.9)  strand : - 104896984...104897082   104897568...104897677   104899850...104899993   104900391...104900625   104901056...104901229   104901891...104902006   104903790...104903852   104904934...104905200   104905833...104905839   Start codon 1 Translation NP_150634.1
	Sequence top
	FASTA 1  GGGAGGAGAG AAAAGCCATG GCCGACAAGG TCCTGAAGGA GAAGAGAAAG CTGTTTATCC GTTCCATGGG TGAAGGTACA 81  ATAAATGGCT TACTGGATGA ATTATTACAG ACAAGGGTGC TGAACAAGGA AGAGATGGAG AAAGTAAAAC GTGAAAATGC 161  TACAGTTATG GATAAGACCC GAGCTTTGAT TGACTCCGTT ATTCCGAAAG GGGCACAGGC ATGCCAAATT TGCATCACAT 241  ACATTTGTGA AGAAGACAGT TACCTGGCAG GGACGCTGGG ACTCTCAGCA GATCAAACAT CTGGAAATTA CCTTAATATG 321  CAAGACTCTC AAGGAGTACT TTCTTCCTTT CCAGCTCCTC AGGCAGTGCA GGACAACCCA GCTATGCCCA CATCCTCAGG 401  CTCAGAAGGG AATGTCAAGC TTTGCTCCCT AGAAGAAGCT CAAAGGATAT GGAAACAAAA GTCGGCAGAG ATTTATCCAA 481  TAATGGACAA GTCAAGCCGC ACACGTCTTG CTCTCATTAT CTGCAATGAA GAATTTGACA GTATTCCTAG AAGAACTGGA 561  GCTGAGGTTG ACATCACAGG CATGACAATG CTGCTACAAA ATCTGGGGTA CAGCGTAGAT GTGAAAAAAA ATCTCACTGC 641  TTCGGACATG ACTACAGAGC TGGAGGCATT TGCACACCGC CCAGAGCACA AGACCTCTGA CAGCACGTTC CTGGTGTTCA 721  TGTCTCATGG TATTCGGGAA GGCATTTGTG GGAAGAAACA CTCTGAGCAA GTCCCAGATA TACTACAACT CAATGCAATC 801  TTTAACATGT TGAATACCAA GAACTGCCCA AGTTTGAAGG ACAAACCGAA GGTGATCATC ATCCAGGCCT GCCGTGGTGA 881  CAGCCCTGGT GTGGTGTGGT TTAAAGATTC AGTAGGAGTT TCTGGAAACC TATCTTTACC AACTACAGAA GAGTTTGAGG 961  ATGATGCTAT TAAGAAAGCC CACATAGAGA AGGATTTTAT CGCTTTCTGC TCTTCCACAC CAGATAATGT TTCTTGGAGA 1041  CATCCCACAA TGGGCTCTGT TTTTATTGGA AGACTCATTG AACATATGCA AGAATATGCC TGTTCCTGTG ATGTGGAGGA 1121  AATTTTCCGC AAGGTTCGAT TTTCATTTGA GCAGCCAGAT GGTAGAGCGC AGATGCCCAC CACTGAAAGA GTGACTTTGA 1201  CAAGATGTTT CTACCTCTTC CCAGGACATT AAAATAAGGA AACTGTATGA ATGTCTGTGG GCAGGAAGTG AAGAGATCCT 1281  TCTGTAAAGG TTTTTGGAAT TATGTCTGCT GAATAATAAA CTTTTTTGAA ATAATAAATC TGGTAGAAAA ATGAAAAAAA 1361  AAAA >gi|73622114|ref|NM_033292.2|Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant alpha GGGAGGAGAGAAAAGCCATGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGGTACA ATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCTGAACAAGGAAGAGATGGAGAAAGTAAAACGTGAAAATGC TACAGTTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCATCACAT ACATTTGTGAAGAAGACAGTTACCTGGCAGGGACGCTGGGACTCTCAGCAGATCAAACATCTGGAAATTACCTTAATATG CAAGACTCTCAAGGAGTACTTTCTTCCTTTCCAGCTCCTCAGGCAGTGCAGGACAACCCAGCTATGCCCACATCCTCAGG CTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAAGCTCAAAGGATATGGAAACAAAAGTCGGCAGAGATTTATCCAA TAATGGACAAGTCAAGCCGCACACGTCTTGCTCTCATTATCTGCAATGAAGAATTTGACAGTATTCCTAGAAGAACTGGA GCTGAGGTTGACATCACAGGCATGACAATGCTGCTACAAAATCTGGGGTACAGCGTAGATGTGAAAAAAAATCTCACTGC TTCGGACATGACTACAGAGCTGGAGGCATTTGCACACCGCCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTGTTCA TGTCTCATGGTATTCGGGAAGGCATTTGTGGGAAGAAACACTCTGAGCAAGTCCCAGATATACTACAACTCAATGCAATC TTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGATCATCATCCAGGCCTGCCGTGGTGA CAGCCCTGGTGTGGTGTGGTTTAAAGATTCAGTAGGAGTTTCTGGAAACCTATCTTTACCAACTACAGAAGAGTTTGAGG ATGATGCTATTAAGAAAGCCCACATAGAGAAGGATTTTATCGCTTTCTGCTCTTCCACACCAGATAATGTTTCTTGGAGA CATCCCACAATGGGCTCTGTTTTTATTGGAAGACTCATTGAACATATGCAAGAATATGCCTGTTCCTGTGATGTGGAGGA AATTTTCCGCAAGGTTCGATTTTCATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCACCACTGAAAGAGTGACTTTGA CAAGATGTTTCTACCTCTTCCCAGGACATTAAAATAAGGAAACTGTATGAATGTCTGTGGGCAGGAAGTGAAGAGATCCT TCTGTAAAGGTTTTTGGAATTATGTCTGCTGAATAATAAACTTTTTTGAAATAATAAATCTGGTAGAAAAATGAAAAAAA AAAA

	CASP1, mRNA isoform beta - Generality top
	Primary source RefSeq : NM_001223.3 (GI:73622112) Name Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant beta Type of transcript mRNA Organism Homo sapiens Length 1301 nt Map 11q23 Location Chromosome 11 (NC_000011.9)  strand : - 104896234...104896326   104896952...104897082   104897568...104897677   104899850...104899993   104900391...104900625   104901056...104901229   104901891...104902006   104904934...104905200   104905833...104905856
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 24 24 1 Exon 2b 25 291 267 1 Exon 4 292 407 116 1 Exon 5 408 581 174 1 Exon 6 582 816 235 1 Exon 7 817 960 144 1 Exon 8 961 1070 110 1 Exon 9 1071 1201 131 1 Exon 10 1202 1294 93 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS8329 Nucleotide CASP1, mRNA isoform beta[NM_001223.3] : 18...1169 Length 1152 Location Chromosome 11 (NC_000011.9)  strand : - 104896984...104897082   104897568...104897677   104899850...104899993   104900391...104900625   104901056...104901229   104901891...104902006   104904934...104905200   104905833...104905839   Start codon 1 Translation NP_001214.1
	Sequence top
	FASTA 1  GGGAGGAGAG AAAAGCCATG GCCGACAAGG TCCTGAAGGA GAAGAGAAAG CTGTTTATCC GTTCCATGGG TGAAGGTACA 81  ATAAATGGCT TACTGGATGA ATTATTACAG ACAAGGGTGC TGAACAAGGA AGAGATGGAG AAAGTAAAAC GTGAAAATGC 161  TACAGTTATG GATAAGACCC GAGCTTTGAT TGACTCCGTT ATTCCGAAAG GGGCACAGGC ATGCCAAATT TGCATCACAT 241  ACATTTGTGA AGAAGACAGT TACCTGGCAG GGACGCTGGG ACTCTCAGCA GCTCCTCAGG CAGTGCAGGA CAACCCAGCT 321  ATGCCCACAT CCTCAGGCTC AGAAGGGAAT GTCAAGCTTT GCTCCCTAGA AGAAGCTCAA AGGATATGGA AACAAAAGTC 401  GGCAGAGATT TATCCAATAA TGGACAAGTC AAGCCGCACA CGTCTTGCTC TCATTATCTG CAATGAAGAA TTTGACAGTA 481  TTCCTAGAAG AACTGGAGCT GAGGTTGACA TCACAGGCAT GACAATGCTG CTACAAAATC TGGGGTACAG CGTAGATGTG 561  AAAAAAAATC TCACTGCTTC GGACATGACT ACAGAGCTGG AGGCATTTGC ACACCGCCCA GAGCACAAGA CCTCTGACAG 641  CACGTTCCTG GTGTTCATGT CTCATGGTAT TCGGGAAGGC ATTTGTGGGA AGAAACACTC TGAGCAAGTC CCAGATATAC 721  TACAACTCAA TGCAATCTTT AACATGTTGA ATACCAAGAA CTGCCCAAGT TTGAAGGACA AACCGAAGGT GATCATCATC 801  CAGGCCTGCC GTGGTGACAG CCCTGGTGTG GTGTGGTTTA AAGATTCAGT AGGAGTTTCT GGAAACCTAT CTTTACCAAC 881  TACAGAAGAG TTTGAGGATG ATGCTATTAA GAAAGCCCAC ATAGAGAAGG ATTTTATCGC TTTCTGCTCT TCCACACCAG 961  ATAATGTTTC TTGGAGACAT CCCACAATGG GCTCTGTTTT TATTGGAAGA CTCATTGAAC ATATGCAAGA ATATGCCTGT 1041  TCCTGTGATG TGGAGGAAAT TTTCCGCAAG GTTCGATTTT CATTTGAGCA GCCAGATGGT AGAGCGCAGA TGCCCACCAC 1121  TGAAAGAGTG ACTTTGACAA GATGTTTCTA CCTCTTCCCA GGACATTAAA ATAAGGAAAC TGTATGAATG TCTGTGGGCA 1201  GGAAGTGAAG AGATCCTTCT GTAAAGGTTT TTGGAATTAT GTCTGCTGAA TAATAAACTT TTTTGAAATA ATAAATCTGG 1281  TAGAAAAATG AAAAAAAAAA A >gi|73622112|ref|NM_001223.3|Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant beta GGGAGGAGAGAAAAGCCATGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGGTACA ATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCTGAACAAGGAAGAGATGGAGAAAGTAAAACGTGAAAATGC TACAGTTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCATCACAT ACATTTGTGAAGAAGACAGTTACCTGGCAGGGACGCTGGGACTCTCAGCAGCTCCTCAGGCAGTGCAGGACAACCCAGCT ATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAAGCTCAAAGGATATGGAAACAAAAGTC GGCAGAGATTTATCCAATAATGGACAAGTCAAGCCGCACACGTCTTGCTCTCATTATCTGCAATGAAGAATTTGACAGTA TTCCTAGAAGAACTGGAGCTGAGGTTGACATCACAGGCATGACAATGCTGCTACAAAATCTGGGGTACAGCGTAGATGTG AAAAAAAATCTCACTGCTTCGGACATGACTACAGAGCTGGAGGCATTTGCACACCGCCCAGAGCACAAGACCTCTGACAG CACGTTCCTGGTGTTCATGTCTCATGGTATTCGGGAAGGCATTTGTGGGAAGAAACACTCTGAGCAAGTCCCAGATATAC TACAACTCAATGCAATCTTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGATCATCATC CAGGCCTGCCGTGGTGACAGCCCTGGTGTGGTGTGGTTTAAAGATTCAGTAGGAGTTTCTGGAAACCTATCTTTACCAAC TACAGAAGAGTTTGAGGATGATGCTATTAAGAAAGCCCACATAGAGAAGGATTTTATCGCTTTCTGCTCTTCCACACCAG ATAATGTTTCTTGGAGACATCCCACAATGGGCTCTGTTTTTATTGGAAGACTCATTGAACATATGCAAGAATATGCCTGT TCCTGTGATGTGGAGGAAATTTTCCGCAAGGTTCGATTTTCATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCACCAC TGAAAGAGTGACTTTGACAAGATGTTTCTACCTCTTCCCAGGACATTAAAATAAGGAAACTGTATGAATGTCTGTGGGCA GGAAGTGAAGAGATCCTTCTGTAAAGGTTTTTGGAATTATGTCTGCTGAATAATAAACTTTTTTGAAATAATAAATCTGG TAGAAAAATGAAAAAAAAAAA

	CASP1, mRNA isoform delta - Generality top
	Primary source RefSeq : NM_033294.2 (GI:73622111) Name Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant delta Type of transcript mRNA Organism Homo sapiens Length 941 nt Map 11q23 Location Chromosome 11 (NC_000011.9)  strand : - 104896234...104896326   104896952...104897082   104897568...104897677   104900391...104900625   104901056...104901229   104901891...104902006   104905150...104905200   104905833...104905856
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 24 24 1 Exon 2a 25 75 51 1 Exon 4 76 191 116 1 Exon 5 192 365 174 1 Exon 6 366 600 235 1 Exon 8 601 710 110 1 Exon 9 711 841 131 1 Exon 10 842 934 93 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS8331 Nucleotide CASP1, mRNA isoform delta[NM_033294.2] : 18...809 Length 792 Location Chromosome 11 (NC_000011.9)  strand : - 104896984...104897082   104897568...104897677   104900391...104900625   104901056...104901229   104901891...104902006   104905150...104905200   104905833...104905839   Start codon 1 Translation NP_150636.1
	Sequence top
	FASTA 1  GGGAGGAGAG AAAAGCCATG GCCGACAAGG TCCTGAAGGA GAAGAGAAAG CTGTTTATCC GTTCCATGGG TGAAGCTCCT 81  CAGGCAGTGC AGGACAACCC AGCTATGCCC ACATCCTCAG GCTCAGAAGG GAATGTCAAG CTTTGCTCCC TAGAAGAAGC 161  TCAAAGGATA TGGAAACAAA AGTCGGCAGA GATTTATCCA ATAATGGACA AGTCAAGCCG CACACGTCTT GCTCTCATTA 241  TCTGCAATGA AGAATTTGAC AGTATTCCTA GAAGAACTGG AGCTGAGGTT GACATCACAG GCATGACAAT GCTGCTACAA 321  AATCTGGGGT ACAGCGTAGA TGTGAAAAAA AATCTCACTG CTTCGGACAT GACTACAGAG CTGGAGGCAT TTGCACACCG 401  CCCAGAGCAC AAGACCTCTG ACAGCACGTT CCTGGTGTTC ATGTCTCATG GTATTCGGGA AGGCATTTGT GGGAAGAAAC 481  ACTCTGAGCA AGTCCCAGAT ATACTACAAC TCAATGCAAT CTTTAACATG TTGAATACCA AGAACTGCCC AAGTTTGAAG 561  GACAAACCGA AGGTGATCAT CATCCAGGCC TGCCGTGGTG ATAATGTTTC TTGGAGACAT CCCACAATGG GCTCTGTTTT 641  TATTGGAAGA CTCATTGAAC ATATGCAAGA ATATGCCTGT TCCTGTGATG TGGAGGAAAT TTTCCGCAAG GTTCGATTTT 721  CATTTGAGCA GCCAGATGGT AGAGCGCAGA TGCCCACCAC TGAAAGAGTG ACTTTGACAA GATGTTTCTA CCTCTTCCCA 801  GGACATTAAA ATAAGGAAAC TGTATGAATG TCTGTGGGCA GGAAGTGAAG AGATCCTTCT GTAAAGGTTT TTGGAATTAT 881  GTCTGCTGAA TAATAAACTT TTTTGAAATA ATAAATCTGG TAGAAAAATG AAAAAAAAAA A >gi|73622111|ref|NM_033294.2|Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant delta GGGAGGAGAGAAAAGCCATGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGCTCCT CAGGCAGTGCAGGACAACCCAGCTATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAAGC TCAAAGGATATGGAAACAAAAGTCGGCAGAGATTTATCCAATAATGGACAAGTCAAGCCGCACACGTCTTGCTCTCATTA TCTGCAATGAAGAATTTGACAGTATTCCTAGAAGAACTGGAGCTGAGGTTGACATCACAGGCATGACAATGCTGCTACAA AATCTGGGGTACAGCGTAGATGTGAAAAAAAATCTCACTGCTTCGGACATGACTACAGAGCTGGAGGCATTTGCACACCG CCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTGTTCATGTCTCATGGTATTCGGGAAGGCATTTGTGGGAAGAAAC ACTCTGAGCAAGTCCCAGATATACTACAACTCAATGCAATCTTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAG GACAAACCGAAGGTGATCATCATCCAGGCCTGCCGTGGTGATAATGTTTCTTGGAGACATCCCACAATGGGCTCTGTTTT TATTGGAAGACTCATTGAACATATGCAAGAATATGCCTGTTCCTGTGATGTGGAGGAAATTTTCCGCAAGGTTCGATTTT CATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCACCACTGAAAGAGTGACTTTGACAAGATGTTTCTACCTCTTCCCA GGACATTAAAATAAGGAAACTGTATGAATGTCTGTGGGCAGGAAGTGAAGAGATCCTTCTGTAAAGGTTTTTGGAATTAT GTCTGCTGAATAATAAACTTTTTTGAAATAATAAATCTGGTAGAAAAATGAAAAAAAAAAA

	CASP1, mRNA isoform epsilon - Generality top
	Primary source RefSeq : NM_033295.2 (GI:73622117) Name Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant epsilon Type of transcript mRNA Organism Homo sapiens Length 416 nt Map 11q23 Location Chromosome 11 (NC_000011.9)  strand : - 104896234...104896326   104896952...104897082   104897568...104897677   104905150...104905200   104905833...104905856
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 24 24 1 Exon 2a 25 75 51 1 Exon 8 76 185 110 1 Exon 9 186 316 131 1 Exon 10 317 409 93 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS8332 Nucleotide CASP1, mRNA isoform epsilon[NM_033295.2] : 18...284 Length 267 Location Chromosome 11 (NC_000011.9)  strand : - 104896984...104897082   104897568...104897677   104905150...104905200   104905833...104905839   Start codon 1 Translation NP_150637.1
	Sequence top
	FASTA 1  GGGAGGAGAG AAAAGCCATG GCCGACAAGG TCCTGAAGGA GAAGAGAAAG CTGTTTATCC GTTCCATGGG TGAAGATAAT 81  GTTTCTTGGA GACATCCCAC AATGGGCTCT GTTTTTATTG GAAGACTCAT TGAACATATG CAAGAATATG CCTGTTCCTG 161  TGATGTGGAG GAAATTTTCC GCAAGGTTCG ATTTTCATTT GAGCAGCCAG ATGGTAGAGC GCAGATGCCC ACCACTGAAA 241  GAGTGACTTT GACAAGATGT TTCTACCTCT TCCCAGGACA TTAAAATAAG GAAACTGTAT GAATGTCTGT GGGCAGGAAG 321  TGAAGAGATC CTTCTGTAAA GGTTTTTGGA ATTATGTCTG CTGAATAATA AACTTTTTTG AAATAATAAA TCTGGTAGAA 401  AAATGAAAAA AAAAAA >gi|73622117|ref|NM_033295.2|Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant epsilon GGGAGGAGAGAAAAGCCATGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGATAAT GTTTCTTGGAGACATCCCACAATGGGCTCTGTTTTTATTGGAAGACTCATTGAACATATGCAAGAATATGCCTGTTCCTG TGATGTGGAGGAAATTTTCCGCAAGGTTCGATTTTCATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCACCACTGAAA GAGTGACTTTGACAAGATGTTTCTACCTCTTCCCAGGACATTAAAATAAGGAAACTGTATGAATGTCTGTGGGCAGGAAG TGAAGAGATCCTTCTGTAAAGGTTTTTGGAATTATGTCTGCTGAATAATAAACTTTTTTGAAATAATAAATCTGGTAGAA AAATGAAAAAAAAAAA

	CASP1, mRNA isoform gamma - Generality top
	Primary source RefSeq : NM_033293.2 (GI:73622118) Name Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant gamma Type of transcript mRNA Organism Homo sapiens Length 1085 nt Map 11q23 Location Chromosome 11 (NC_000011.9)  strand : - 104896234...104896326   104896952...104897082   104897568...104897677   104899850...104899993   104900391...104900625   104901056...104901229   104901891...104902006   104905150...104905200   104905833...104905856
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1 1 24 24 1 Exon 2a 25 75 51 1 Exon 4 76 191 116 1 Exon 5 192 365 174 1 Exon 6 366 600 235 1 Exon 7 601 744 144 1 Exon 8 745 854 110 1 Exon 9 855 985 131 1 Exon 10 986 1078 93 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI :  Nucleotide CASP1, mRNA isoform gamma[NM_033293.2] : 18...953 Length 936 Location Chromosome 11 (NC_000011.9)  strand : - 104896984...104897082   104897568...104897677   104899850...104899993   104900391...104900625   104901056...104901229   104901891...104902006   104905150...104905200   104905833...104905839   Start codon 1 Translation NP_150635.1
	Sequence top
	FASTA 1  GGGAGGAGAG AAAAGCCATG GCCGACAAGG TCCTGAAGGA GAAGAGAAAG CTGTTTATCC GTTCCATGGG TGAAGCTCCT 81  CAGGCAGTGC AGGACAACCC AGCTATGCCC ACATCCTCAG GCTCAGAAGG GAATGTCAAG CTTTGCTCCC TAGAAGAAGC 161  TCAAAGGATA TGGAAACAAA AGTCGGCAGA GATTTATCCA ATAATGGACA AGTCAAGCCG CACACGTCTT GCTCTCATTA 241  TCTGCAATGA AGAATTTGAC AGTATTCCTA GAAGAACTGG AGCTGAGGTT GACATCACAG GCATGACAAT GCTGCTACAA 321  AATCTGGGGT ACAGCGTAGA TGTGAAAAAA AATCTCACTG CTTCGGACAT GACTACAGAG CTGGAGGCAT TTGCACACCG 401  CCCAGAGCAC AAGACCTCTG ACAGCACGTT CCTGGTGTTC ATGTCTCATG GTATTCGGGA AGGCATTTGT GGGAAGAAAC 481  ACTCTGAGCA AGTCCCAGAT ATACTACAAC TCAATGCAAT CTTTAACATG TTGAATACCA AGAACTGCCC AAGTTTGAAG 561  GACAAACCGA AGGTGATCAT CATCCAGGCC TGCCGTGGTG ACAGCCCTGG TGTGGTGTGG TTTAAAGATT CAGTAGGAGT 641  TTCTGGAAAC CTATCTTTAC CAACTACAGA AGAGTTTGAG GATGATGCTA TTAAGAAAGC CCACATAGAG AAGGATTTTA 721  TCGCTTTCTG CTCTTCCACA CCAGATAATG TTTCTTGGAG ACATCCCACA ATGGGCTCTG TTTTTATTGG AAGACTCATT 801  GAACATATGC AAGAATATGC CTGTTCCTGT GATGTGGAGG AAATTTTCCG CAAGGTTCGA TTTTCATTTG AGCAGCCAGA 881  TGGTAGAGCG CAGATGCCCA CCACTGAAAG AGTGACTTTG ACAAGATGTT TCTACCTCTT CCCAGGACAT TAAAATAAGG 961  AAACTGTATG AATGTCTGTG GGCAGGAAGT GAAGAGATCC TTCTGTAAAG GTTTTTGGAA TTATGTCTGC TGAATAATAA 1041  ACTTTTTTGA AATAATAAAT CTGGTAGAAA AATGAAAAAA AAAAA >gi|73622118|ref|NM_033293.2|Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant gamma GGGAGGAGAGAAAAGCCATGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGCTCCT CAGGCAGTGCAGGACAACCCAGCTATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAAGC TCAAAGGATATGGAAACAAAAGTCGGCAGAGATTTATCCAATAATGGACAAGTCAAGCCGCACACGTCTTGCTCTCATTA TCTGCAATGAAGAATTTGACAGTATTCCTAGAAGAACTGGAGCTGAGGTTGACATCACAGGCATGACAATGCTGCTACAA AATCTGGGGTACAGCGTAGATGTGAAAAAAAATCTCACTGCTTCGGACATGACTACAGAGCTGGAGGCATTTGCACACCG CCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTGTTCATGTCTCATGGTATTCGGGAAGGCATTTGTGGGAAGAAAC ACTCTGAGCAAGTCCCAGATATACTACAACTCAATGCAATCTTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAG GACAAACCGAAGGTGATCATCATCCAGGCCTGCCGTGGTGACAGCCCTGGTGTGGTGTGGTTTAAAGATTCAGTAGGAGT TTCTGGAAACCTATCTTTACCAACTACAGAAGAGTTTGAGGATGATGCTATTAAGAAAGCCCACATAGAGAAGGATTTTA TCGCTTTCTGCTCTTCCACACCAGATAATGTTTCTTGGAGACATCCCACAATGGGCTCTGTTTTTATTGGAAGACTCATT GAACATATGCAAGAATATGCCTGTTCCTGTGATGTGGAGGAAATTTTCCGCAAGGTTCGATTTTCATTTGAGCAGCCAGA TGGTAGAGCGCAGATGCCCACCACTGAAAGAGTGACTTTGACAAGATGTTTCTACCTCTTCCCAGGACATTAAAATAAGG AAACTGTATGAATGTCTGTGGGCAGGAAGTGAAGAGATCCTTCTGTAAAGGTTTTTGGAATTATGTCTGCTGAATAATAA ACTTTTTTGAAATAATAAATCTGGTAGAAAAATGAAAAAAAAAAA

	P29466 - Generality top
	Primary source Uniprot : P29466 Name Caspase-1 Alternative name(s) Interleukin-1 beta convertase Interleukin-1 beta-converting enzyme p45 Synonym(s) CASP-1 ICE IL-1 beta-converting enzyme IL-1BC Organism Homo sapiens Length 404 aa Protein existence ---
	External Links top
	ArrayExpress P29466   BRENDA 3.4.22.36   Prints PR00376   Smart SM00115   SM00114   Refseq NP_150637.1   NP_150636.1   NP_150635.1   NP_150634.1   NP_001214.1   Uniprot P29466   EBI EBI-516667   InterPro IPR015917   IPR002398   IPR002138   IPR016129   IPR001309   IPR011600   IPR011029   IPR017350   IPR001315   KEGG hsa:834   PDB 3E4C   3D6M   3D6H   3D6F   2HBZ   2HBY   2HBR   2HBQ   2H54   2H51   2H4Y   2H4W   2H48   2FQQ   1SC4   1SC3   1SC1   1RWX   1RWW   1RWV   1RWP   1RWO   1RWN   1RWM   1RWK   1ICE   1IBC   1BMQ   PDBsum 3E4C   3D6M   3D6H   3D6F   2HBZ   2HBY   2HBR   2HBQ   2H54   2H51   2H4Y   2H4W   2H48   2FQQ   1SC4   1SC3   1SC1   1RWX   1RWW   1RWV   1RWP   1RWO   1RWN   1RWM   1RWK   1ICE   1IBC   1BMQ   PROSITE PS50208   PS50207   PS01121   PS01122   PS50209   Pfam PF00656   PF00619   SUPFAM SSF47986
	General annotation (Comments) top
	Catalytic activity Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala- Asp-|-. Enzyme regulation Specifically inhibited by the cowpox virus Crma protein. Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Ptm The two subunits are derived from the precursor sequence by an autocatalytic mechanism. Similarity Belongs to the peptidase C14A family. Contains 1 CARD domain. Subcellular location Cytoplasm. Subunit Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Tissue specificity Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
	Ontologies top
	Biological process proteolysis [GO:0006508] apoptosis [GO:0006915] signal transduction [GO:0007165] positive regulation of I-kappaB kinase/NF-kappaB cascade [GO:0043123] Cellular component cytoplasm [GO:0005737] Molecular function cysteine-type endopeptidase activity [GO:0004197] protein binding [GO:0005515] caspase activator activity [GO:0008656]
	Binary interactions top
	With Uniprot accession IntAct IL1A P01583 EBI-516667, NLRC4 Q9NPP4 EBI-516667,EBI-1222527 NLRP1 Q9C000 EBI-516667,EBI-1220518 ??? Q7CL55 EBI-516667,EBI-2840495 FGF2 P09038 EBI-516667,EBI-977447
	Alternative product(s) top
	Uniprot Identifier Difference(s) with the 'canonical' sequence Notes Sequences Isoform Alpha P29466-1 --- 'Canonical' sequence Get Fasta Isoform Beta P29466-2 92-112  :  Missing --- Get Fasta Isoform Gamma P29466-3 20-112  :  Missing --- Get Fasta Isoform Delta P29466-4 20-112  :  Missing 288-335  :  Missing --- Get Fasta Isoform Epsilon P29466-5 20-335  :  Missing --- Get Fasta Isoform Zeta P29466-6 1-39  :  Missing --- Get Fasta
	Sequence annotation top
	Feature key Position Length Description Feature identifier Molecule processing           Propeptide 1 - 119 119 PRO_0000004521 Propeptide 298 - 316 19 PRO_0000004523 Region           Domain 1 - 91 91 CARD P29466-DOMAIN-1 Sites           Active site 237 - 237 1 P29466-ACT_SITE-237 Active site 285 - 285 1 P29466-ACT_SITE-285 Natural variations           Natural variant site 15 - 15 1 R -> H (in dbSNP:rs1042743) VAR_048615 Alternative sequence 1 - 39 39 Missing VSP_021670 Alternative sequence 20 - 335 316 Missing VSP_000797 Alternative sequence 20 - 112 93 Missing VSP_000799 Alternative sequence 92 - 112 21 Missing VSP_000798 Alternative sequence 288 - 335 48 Missing VSP_000800 Experimental info           Mutagenesis 285 - 285 1 C->A,S: Loss of activity P29466-MUTAGEN-285
	Sequence top
	FASTA 1  MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS VIPKGAQACQ ICITYICEED 81  SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS 161  RTRLALIICN EEFDSIPRRT GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR 241  EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG VSGNLSLPTT EEFEDDAIKK 321  AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL 401  FPGH >sp|P29466|CASP1_human Caspase-1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEED SYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSS RTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKK AHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYL FPGH