(CASP3) caspase 3, apoptosis-related cysteine peptidase [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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3017
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Official symbol
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CASP3
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Official name
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caspase 3, apoptosis-related cysteine peptidase
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 4 (NC_000004.11) : 185548849...185570628 (-)
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Map
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4q34
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Length
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21780 nt
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NM_004346.3
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CASP3, mRNA isoform alpha
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NM_032991.2
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CASP3, mRNA isoform beta
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Accession
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Name
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Organism
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Length
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P42574
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Caspase-3
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Homo sapiens
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277 aa
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D3DP53
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Caspase 3, apoptosis-related cysteine peptidase, isoform CRA_a [submitted name]
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Homo sapiens
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277 aa
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Synonyms |
SCA-1; Yama; CPP32B; CPP32; apopain
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Alternative name(s) |
Yama; apopain; procaspase3; SREBP cleavage activity 1; cysteine protease CPP32; PARP cleavage protease; caspase 3, apoptosis-related cysteine protease
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Summary |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl
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1 |
CATCTCCCGG |
CGGCGGGCCG |
CGGAAGCAGT |
GCAGACGCGG |
CTCCTAGCGG |
ATGGGTGCTA |
TTGTGAGGCG |
GTTGTAGAAG |
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81 |
GTATGAGGAG |
GCTGTGCGGT |
GACTGCCGCC |
CTCGCTCCGG |
GCCGTCAGCC |
CTGCCCCCGC |
TCCCTGCGTT |
CTCCCAGGCC |
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161 |
CTGCGCCCGC |
CCGGGTACCT |
GCCCGGTCTG |
GAAGGCGGAG |
TGTTTGTTTT |
GCCACCTCGC |
CCGGGCGGGG |
GCGAGCAGTG |
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241 |
AAGCCCGCGG |
AGCGAGAGAC |
TTGGCCCGGA |
GGCGGGAGCC |
TGGGCCGGGG |
CCGGGGAAGC |
CAGGCAGCGG |
GTTAAGGCTT |
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321 |
TTGATTTAGG |
GAGAGGGACC |
TGGGGGTAAC |
CTAAGGAAAG |
GCCTCAGGTC |
ATCGGAGGGG |
AGACCTGGCC |
CGGGGGCGGG |
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401 |
AGGCTGGGCT |
GGGACCGGGG |
AGGCCGGGCA |
GCGCGAGGCC |
GGGCCGGGGA |
GGCCAGGCAG |
CGGGAGGCCT |
GGCCAGGGGA |
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481 |
ACCGAGCCCG |
GGGCCGGGAG |
GTCGGGCACG |
GGGCACCGAG |
CTCCGAGGGC |
GGGAGACCTG |
GCGGCCGGCC |
GAGTGCCGGA |
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561 |
AGGCCGGGTC |
AGGCGGCGGA |
AGGCAGCGGC |
AAGCTGGGAA |
ACGGACGGCG |
CTACCGCCGG |
CGGAGGAGTG |
GCCCCGGGAA |
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641 |
GCGGTGCTGC |
GAGGGCTGGG |
GCGGCCGGGT |
GCTGACTGTG |
AGATACTCGC |
CCTGGGGGCT |
GATCCTTCCA |
ATTTTGGACG |
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721 |
AGGCTTCCGT |
CTCTGCTGCC |
TTCCATGCCT |
GGGGCCTGGA |
TTATCCCGGG |
TTGACAATGT |
GGTTTAGCTC |
TTCCAGAGAG |
|
801 |
ATAGTTGCAG |
GGTTTAAACT |
CCAATTCCTT |
TTCGGCCCTG |
CAGAGTTTCG |
TGAGTGCTCG |
CAGCTCATAC |
CTGTGGCTGT |
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881 |
GTATCCGTGG |
CCACAGCTGG |
TTGGCGTCGC |
CTTGAAATCC |
CAGGCCGTGA |
GGAGTTAGCG |
AGCCCTGCTC |
ACACTCGGCG |
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961 |
CTCTGGTTTT |
CGGTGGGTGT |
GCCCTGCACC |
TGCCTCTTCC |
CCCATTCTCA |
GTAAGTGGCA |
CCCAAGCAGG |
AAACCGGAAA |
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1041 |
ACATCGTTCG |
CAGCCCCCTC |
TCGCCCACCC |
ACTTCTTTTC |
CTGCTTAGTC |
GCCAAGCCTT |
GTCGACCTTG |
TAAATGTCTG |
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1121 |
CCAGATCTGT |
CCGCGTCTCT |
CTATCTCTGA |
TTTCAGCCGT |
CTGACCACAG |
CAGCCTCTTC |
CCTGGTCTCT |
CCACTTCCAG |
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1201 |
ACCCGCCTGC |
TCCTTTGCAG |
TCCACTTTTT |
ACAGCACAGG |
CAGAGGGATC |
TTTATGAAAT |
GAAAGTCTAG |
AAAGCTCGTC |
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1281 |
CTTTGCCCTT |
AGGTTAAACC |
CAGCACTTAA |
TATGGCTAAC |
AAACCCCTGC |
GTGTGTTGGG |
TCCTGAGTGC |
CCCCACCCCT |
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1361 |
CCTTATCTTT |
AGCACCGGTT |
CGATTTCTGC |
ACGGCAATGC |
TGACCTTCAT |
ACCTAGTGTC |
TGCCTGCAAC |
ACCTCTGCAC |
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1441 |
TCCCTTTCTC |
CCGCCATCAC |
ATTTGATTAG |
AAGAGCTGCT |
ACTTAAATTT |
CTGTTTTCAT |
TAAACAGTTT |
AAGGTTAAAT |
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1521 |
CTTCCTATGC |
TGTGTTCTTT |
CTGCAGCCAG |
CATTCCCTAA |
GAGAGATGTG |
TCATATCCTT |
TGCAGTTGCT |
TGTTTACTAT |
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1601 |
CTTCCCTGCT |
AGATTTGCAA |
GCAAACTCCA |
GGAGGGACGG |
ACTTGGTTTA |
TCTTGGTATC |
CTTAGTGTCT |
TGCCCCAAAT |
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1681 |
GCGGGGCCTG |
GCATAACACA |
GTGAATGCCC |
ATCCATTGTA |
TTTTTACTTT |
TATGCCCTAT |
CTAGAAAAAG |
TAGACCTGGT |
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1761 |
TTAGGATTAT |
TCAGCAAATA |
ATAATTAGAA |
AAGAAATGGT |
AGAGGTGACA |
TACGGAGTCA |
CTGAAACGAT |
GTAAACCTGC |
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1841 |
AAGATAGCTG |
AAAGAGGGCC |
AGGCAAGGTG |
GTTAGACCAG |
ACTGTATCAA |
AATGGGCTCA |
GCCACTGTGA |
ATGTGCGTGC |
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1921 |
TGTGGTTACA |
TAATCTCTAA |
AAATGAAATA |
TAAAGCTTAA |
ATCATCTCTA |
TCACAGCCCG |
ATGCTTGGAC |
TTTGGTTTTG |
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2001 |
CTTTGCCTTT |
TTGCAAAAGA |
AGGTTTTTGA |
AAGTGAAAAT |
TATTTTAGTG |
AATGGATGAA |
CAGTTTATTG |
GAGTATGGCA |
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2081 |
ATAAAACCTG |
TTCAAAGTAA |
GAGACATTAG |
ACATTGTACC |
TAGTTAAATC |
AGATTTGCTT |
TTGCTATCCT |
GAATAAAGGC |
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2161 |
CTTGCCTCTT |
GCCATTTGAA |
GAGACTGGCA |
TCTGATATAG |
GCAATTATAA |
TGCTTCTTTA |
CTGTTTTGTT |
TTCAAACCTC |
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2241 |
GTTTAACACA |
ATCTCCTACT |
GCTTCATCCC |
CCTACAAAGC |
AGTCTTTATT |
TTGATGAATG |
ATATATTACA |
TTGCTTCTGG |
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2321 |
TGCCTACTAT |
TAGATCTTTA |
AGCTCTGCCC |
CAAAGATAAG |
AAGCACTGGT |
GTTTGGGCCT |
AAACAAAGAT |
GGGAGAATTC |
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2401 |
TTAGATTTAT |
ATAATATTCT |
TTCTCTGCAT |
GTTTTGTTCT |
TACCTTCACA |
TGTTGCCTGT |
AGAGCTTCTT |
TGCATTACAA |
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2481 |
TAATGAAATC |
AAGCTACCTG |
ATATGTATTG |
GACACGGTCT |
GGCATCTGCC |
TTGTTGAGCC |
ACTTTTGAAT |
ACCAGTGAGC |
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2561 |
ATCGGTATAA |
GCCCTGAATA |
GAGATAGGGT |
TTGTCTCTTC |
CACTGCTTGA |
TACACTCAGG |
GTCTAGTATA |
GTACTCTGCA |
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2641 |
CACAGTTGGT |
GTTCAGTAAA |
TTGTTATGGT |
GCAAATATCA |
AATGAATAAA |
TGCTACTGAA |
TCTGAGTTTT |
GGCAGTTTCA |
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2721 |
GTCTTCCTGA |
CAGCAGGATT |
TCTTCAAGCG |
GTTTTAAACT |
TGAATCTGAT |
TCTGCAAAGT |
AGTCATCCTT |
GGTGGGAGTG |
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2801 |
CTGAGGCTTT |
AAAGTCATCT |
GTAATTTTTA |
TAAAAAGGCA |
TCCGAGATCC |
TCCATTTTAC |
ACTTATATCA |
TACAAATCAT |
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2881 |
TTAGATCTGT |
GAAGGCTTTC |
CCATTTTCTC |
CTTTTGTCCT |
TCCAAAAACA |
CCATCTTAGG |
ACTTCACCTG |
GCACAGGGAA |
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2961 |
GACAGATCGT |
TTGCACATAC |
TAAGTGCCCT |
TCTTTCTAAC |
TTGTGTCATA |
AACTCAGAGG |
CTTTGAATAG |
TGGAGAGTGC |
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3041 |
TCTGTACTGT |
CTTCCTGGTC |
ACGTGGCCCT |
TGCCAGAGGA |
AAGGAAAGGA |
TGGTTTGTTT |
GTATAGTACA |
ATGGAACTTA |
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3121 |
TTTCAATGTA |
TTCTGTATTT |
GATTTTACAT |
TCCTGTTCTC |
ATATTTTTAC |
CTTAATTACA |
TAACAAATAT |
TAAAAGATTG |
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3201 |
ACTTCACCAG |
GCCCAGTTAC |
AATCGCCAGT |
TTGATAATTC |
TTATACGTAC |
TCAAATGAAT |
TCAGAGACCA |
GATGGGAAAA |
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3281 |
GATTTTGATA |
AAACCTCTGG |
TACATCACAA |
CTGAAGTCTT |
TTCTTGTCCA |
AACTATTGTG |
AAACAGATGT |
TCTTTCTGTT |
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3361 |
TCATTTGCTA |
AATCTGGAAA |
CGTGACTGCT |
TTTGAGACTT |
TGTCCTCTCT |
GACAGGTAAT |
AAATATAATC |
CTGATATTTT |
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3441 |
TCAAGTTGTT |
TGACAGAAGT |
GTAATCTCCC |
CAGAAGTCCT |
GCTGGACAGG |
CTTCACTTTT |
CCTTTGGAGG |
AACACAGAGA |
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3521 |
TACAGGGAAT |
ATGTTTTAAT |
GACATATACC |
TAACGCTGAA |
CATGAAACCA |
GTTATTTTAC |
TTTTATTATT |
ATTATTTTTA |
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3601 |
GAAACAGCCT |
TGCTGTGTCA |
CCCAAGCTCA |
AGTGCAGTGG |
TGCGATCATA |
GCTCACTGCA |
GCCTCCAATT |
CCTATGCTCA |
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3681 |
AGTAATCCTC |
TTGCCTCAGC |
CTCCTGAGTA |
GCTGGGACTA |
CAGGTGTGTG |
CCACCATGCC |
AGGCTACTTG |
TTTTTACTTT |
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3761 |
GTTATAGAGA |
TGGGGTCTCT |
CTGTGTTGCC |
CAGACTGGTC |
TTGAACACAT |
GATCTCAACC |
ATTCCTCCCA |
CCTTGGCCTC |
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3841 |
CCAAAGTGCT |
GGGATTACAG |
GCGCGAGCCA |
CTGTGTCTGG |
CCTATTTCAC |
TTTAGAAGTA |
AATTGAATGC |
CACATGCGAA |
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3921 |
GTTTGTTAAA |
TTTTTTTAAA |
AAAGGAAAGA |
AAACACAAAA |
GTAAACTACC |
TAGTCGCATC |
AGAAATGCCA |
TAGTCATTTT |
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4001 |
TGCCATTTTT |
TCATTCATTA |
GAATTCAGTG |
CATTATGTTA |
TTTTGTTATC |
TCTGCAGTAA |
CTTTCTATCA |
TGTTATTTAT |
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4081 |
TTTCTTTGTC |
TTATTTAAAG |
CTTCTGAGAT |
TATGGATTTT |
TGTTTCCTTC |
CCTGAAGTTA |
AGTGTTATCA |
TTCCTATATA |
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4161 |
GTACTAAGCT |
GTCTACAGAA |
TAGTGGGAGT |
CTGCCCTCTT |
GAGTTGGGAA |
GATCCTAGTT |
TGAATCTTGG |
CTGTGCGACT |
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4241 |
TTAAAGTTCA |
TTAACTTCTC |
TTAGCCTCAG |
TCACCTGAAC |
TCTGCAGTGG |
GGATCCTTAT |
GCCTCAGAGT |
GTCATTGGGA |
|
4321 |
GGACTCACGA |
AAATACGCTT |
GTACTTTGAG |
TTCAGTACCT |
AGCCTGTATG |
AGCCAGCATT |
AAGAGGGACA |
GTCATCACGC |
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4401 |
AGCGCTTTGC |
ACACAGCTCT |
CACGCCACAT |
CCTTTGGCTA |
CTGTTTTGGT |
AAATCTTTAC |
TAGTAAATGT |
TTCTTAAAAG |
|
4481 |
CATTTACATT |
CATGGACATG |
ATTCAGAAAC |
TAACAGTTGT |
TTTTTAGGTC |
TCACTTTGAG |
ATTTAAAAAC |
CCTTAGGGCA |
|
4561 |
GAGACCAGAT |
TTTATTTCTT |
ACCTCAGAGT |
TTCCCTGTAG |
GACAGGAACC |
AGCAACAGCC |
TAATGAGCTG |
ATTAAGAATT |
|
4641 |
TTAGAGATTT |
AAAATTTAAA |
TTAGGATTGC |
CAGTTTTAGA |
GACTGGCACA |
TAAATGTTTT |
CATTTAAGGC |
AGTGACTGTT |
|
4721 |
TCCTTTAGGA |
TATGATTTTT |
TATCTTTCTA |
AGATGAGATC |
ACCATCCTCA |
GAATAATTTG |
TACCCCGCTG |
GGCACTAGCT |
|
4801 |
AATGGAGGTG |
ATGTCATGCT |
AAGCAGCACT |
TCAGTGAGTT |
TTGCGGGAAC |
CAAAGCTCTG |
CTCCCAGGAG |
TGTGGATTTG |
|
4881 |
GTGCTTTCAT |
GTGGAAAAAG |
CGGATGATGA |
CAAGTAGAGA |
GCAAATGTGC |
GCATGTCTGA |
TGCTGTAAGG |
ATTTCCTTTA |
|
4961 |
CCATCATATA |
AATTTTTAAA |
GTATATCAAA |
ATAAACTGAT |
AACTGAGAAA |
ATATATGTTG |
TTCAGATACT |
AATAATGAAG |
|
5041 |
TTAATGAAGT |
CCACTATAGT |
ATTTGTCCCT |
GAGAAATCTT |
TATCAAATAT |
TTTAAATCCT |
ATTGTAAAAT |
AATGTATTTT |
|
5121 |
TTCTTTCAGT |
TTTAGAGACT |
GGCAATCCTA |
ATTTAACATC |
TCCTTTTGAA |
TTCCCCACCA |
CAGGCACACT |
TTCACACATT |
|
5201 |
CACTCTTTAA |
TAACAGGTTG |
TTTCAAATTG |
TTAATACTTT |
ATAGCTTAAT |
ATAGAAATTT |
CACTTTAGAA |
ATTAATTTTT |
|
5281 |
ATTTCTCTGC |
CTTAATGCTA |
TAGATGTTGT |
AGTCTGCTTT |
ACTTCAGTAT |
TGTAATGAGT |
AGTTGGCTAA |
CCACCATGTA |
|
5361 |
AATAGGGAGA |
ACATTCTAGT |
TTTTTACTTG |
TGTAGGAAAA |
CACAGCTTGA |
AATGTCTAAG |
TATCTATTTT |
AGAGTGAAGT |
|
5441 |
AAATTTATAC |
TGACAATATT |
TTTTTGTGTT |
TGAAGACCTG |
ACTGTTACAG |
CGTTGGTGGC |
AAGTGTTAAG |
GGATCCAGGA |
|
5521 |
ACTAGACAAG |
TGATTCTGAG |
ACCTGAGTTC |
CAGGTTTCTA |
AGTAATATCA |
GTTGGTCTAC |
TGAGAACTTT |
GCCATAAACA |
|
5601 |
TATGTGTTCA |
GAAATTTCCT |
TTCTTAGCAG |
CAGCATCCTG |
AATTGAACAG |
AATTACACAC |
ACATCAGCCC |
AGTAAGAAAC |
|
5681 |
AATTCATGTT |
AAGTCCATTG |
CTATGCCAGG |
ATAAATCTTT |
TAAATCACAA |
TTATTTTTCC |
TATTTATATT |
TTGTCAAATA |
|
5761 |
AGAATGTTCT |
AAAAACCAAA |
ATTTCTGTTT |
TCTTTTTTTT |
TTTTTTTTTT |
TTTTGAGACG |
GAGTCTCACT |
CTGTCGCCCA |
|
5841 |
GGCTGGAGTG |
CAGTGGCGCG |
ATCTCGGCTC |
ACGGCAAGCT |
CCACCTCCCG |
GGTTCACGCC |
ATTCTCCTGC |
CTCAGCCTCC |
|
5921 |
TGAGTAGCTG |
GGACTACAGG |
CACCCACCAC |
CACGCCTGGC |
TAATTTTTTA |
TATTTTTAGT |
AGAGACGGGG |
TTTCACCGTG |
|
6001 |
TTAGCCAGGA |
TGGTCTTGAT |
CTCCCGAACT |
TGTGATCCGC |
CCGCCTCGGC |
CTCCCAAAGT |
GCTGGGATTA |
CAGGCAAAAT |
|
6081 |
TTCTGTTTTC |
ATTTAAGGCA |
GTGACTATTT |
CCCTTAGGAT |
GTGATTTTTT |
TATCCTTCTA |
AGATGAGATC |
ACCATCCTCA |
|
6161 |
GAATAATTTG |
TACCCTGCTG |
GGCACTAGCT |
AATGGAGGTG |
ATGTCATGCT |
AAGCAGCACT |
TCAGTGAGTT |
TTGCGGGAAC |
|
6241 |
CAAAGCTCTG |
CTCCCAGGAG |
TGTGGATTTG |
GTGCTTTCAT |
GTGGAAAAAG |
CGGATGATGA |
CAAGTAGAGA |
GCAAATGTGC |
|
6321 |
GCATGTCTGA |
TGCTGTAAGG |
ATTTCATCTA |
CCATCATATA |
AATTTTTAGA |
AGTATATCAA |
AATAAACTGA |
TAACTGAGGC |
|
6401 |
AATGTATGTT |
GTTCAGATAC |
TAATAATGAA |
GTTAATGAAG |
TCCACTATAG |
TATTTGTATA |
GTATTTGTAT |
ATTACAGTAC |
|
6481 |
TCTGAAAAGC |
TGGTCACTAT |
TTAAAGTTTC |
CATTACCAGT |
CACAAGGAGA |
GAATAATTTT |
ATCCCACAAT |
TTTATTGCTG |
|
6561 |
GCAAAAGACA |
CAAGTTTATT |
AAAAGTCAGT |
ATTTCAGTGT |
AAGAGTTACT |
AGACTGTTTG |
CAGAAGTGTT |
CAAAAGAGAT |
|
6641 |
CTTTAGGTCC |
TTGGTTGTCT |
GTGGAAGCTG |
ATCAGCATTT |
AGGGGTTCCT |
GAGCACAGAC |
TGTGAACCCT |
GCATTTGGCA |
|
6721 |
CATGCATTCA |
GAGAGCCAAT |
TTGAGGCAGA |
CTGGGGGCTA |
GAAAGGATAC |
TGCCAGGAGC |
TCCAGGTTCA |
GCTTCCGAAG |
|
6801 |
TTATTAAGTC |
TTATTTCCCA |
GTTTTTAAAT |
TAGACTTCAT |
TTTTTAGAGC |
AGTTTTAGGT |
TCAAACCAAA |
ATTGAGAAGA |
|
6881 |
ACGTACAGAG |
ACATCCTGTA |
TCCCACCTGC |
CCCCCAACAC |
GTGCGTAGTC |
TCCCCCATTA |
TCAACATCCT |
GCACCAGAGT |
|
6961 |
AGTACATTCT |
TACAAAGGAA |
CCTACACTGA |
CACGTCATCA |
TCACCCAAAC |
GCCATCGTTC |
ACAATCAAGT |
TCACTCTTGG |
|
7041 |
TGCTGTTTAT |
CCTATGGTTT |
TGGACAAATT |
TACAAGGACT |
TGTATCCACC |
ATTATATTGT |
CACACTGAGT |
AGTTTCACTG |
|
7121 |
CCTTAAAAAG |
TCTCCGTGCG |
GGCCGGGCAC |
GGTGGCTCAC |
GCCTGTAATC |
CCAGCACTTT |
GGGAGGCCAA |
GGCGGGCAGA |
|
7201 |
TCACGAGGTT |
AGGAGTTCGA |
GACCAGCCTG |
GCCAACATGG |
TGAAACCCCG |
TCTCTACTAA |
AAATACAAAA |
ATTAGCCTGG |
|
7281 |
CATGGTGGCA |
TGCGCCTGTA |
ATCCCAGCTA |
CTCAGGAGGC |
TGAGGCAGGA |
GAATCGCTTG |
AAACCTAAAG |
GCGGAGGTTG |
|
7361 |
CAGTGAGCCG |
AGACCACGCC |
ACTGCACTCC |
AGCCTGAGCA |
AGGAGCGAAA |
TTCCATCTCA |
AAACAAAAAA |
AAAAAAAAAA |
|
7441 |
AAAAATTCTC |
TGTGCTGTCT |
CCCTCCCTCC |
TAGCCACTGG |
CAACCACTGA |
TCTTTTTACT |
GTCTCCATAG |
TTTTGCCTTT |
|
7521 |
TCCAGATTGT |
CAGATAGTTG |
GAATCATGCG |
GTATATATGG |
CCTTTTCAAA |
CTGGCTTCTT |
TCACTTAGTA |
ATAATGCATT |
|
7601 |
TAAAGTGTTC |
ATGGCTTGCT |
AGCTCATTTC |
TTTTTAGTGC |
TCAGTAATAT |
TCTGTTCTCT |
GGATATACCA |
CGGTTTATTT |
|
7681 |
ATTCATTCAC |
CGACTGAAGG |
ACATCTTAGT |
TGCTTCTAGT |
TTTGACAGTT |
ATGAATAAAA |
CTGCTATAAA |
CATCTGTGTG |
|
7761 |
CAGGCTTTTG |
TGTGAACATA |
AGTTTTCAAC |
TCCTTTGGGT |
AAATACCAAA |
GAGTGCGTAT |
TTACCATATG |
GCTGGATCAT |
|
7841 |
ATGGTAAGAG |
TATGTTTAGT |
TTTGTAGGAA |
ACTGCCAAAC |
TGTCTTTCGA |
GTTGGCTGTA |
CCATTTTGCA |
TTTCCACGAG |
|
7921 |
CAGTGATTGA |
GAATCCCTGT |
TGCTCCACAT |
CCTCACCAGC |
ATTTGGTGTT |
GATGGTGTTC |
TGGTTTTGGC |
CATTCTGCTA |
|
8001 |
GGTATGTAAT |
GATACCTCAT |
TGTTGCTTTA |
ATTAGCATTT |
CCCATTATTT |
GCAGTCTGTG |
TATCTTTGAT |
GAGGCCCACT |
|
8081 |
GGATTTTCAC |
TTTAGATTTT |
CTATAGATTG |
GCCATAAAGT |
CTTGAAACAA |
AGATATTTTC |
TCATGGATTA |
TAATGCAATA |
|
8161 |
TCAGTAAACT |
ATTATGTGTT |
CACCTACGTT |
TCCAGACTTG |
TTAGCTACCC |
TGTACTGTTC |
TCTCAGTTAA |
TCAAGTTAAC |
|
8241 |
CACAATTTGT |
TTCTCAACCA |
CAGGTGGCTA |
ATGATTTTGT |
ATGTGGTCTG |
TCCGCTTTGA |
ATTGATGTGC |
ATGGGGCAAG |
|
8321 |
TTGGTCTCTA |
TGATATTCAT |
GGTTCAAGGA |
AGTTCGAGAT |
TTCCTGGTAC |
CTAATACATG |
TTTATTGTAC |
ATATGAAAGA |
|
8401 |
AAAAAGGGCA |
GATAGAGGGG |
AACATGGTAC |
TGAGCATGAT |
AGAGGCAAGG |
AAGGGTGGCT |
ACTTTGATAG |
GAGAATACCC |
|
8481 |
CTATTTTTGT |
CACTCTTGAA |
ACAGGGCCAA |
GAGTTGAAAT |
TGGCTAGAAC |
AATCCTGACC |
TTTGTTGATA |
TTATTTTATA |
|
8561 |
GAATAATATT |
TGTTACTGTT |
TTCTCACTTT |
TAAAAAATGC |
AGATGTTATA |
GAAAAATTAG |
AAGATATAGA |
GGAATGTTAA |
|
8641 |
GGAGTAAATA |
AGGTGTCAGT |
AATGCCATCA |
CCCAGACAGC |
CACTGTTAAT |
AAATATGTTA |
ATATGTGAAG |
ACATACTAAT |
|
8721 |
ATGTAATATG |
TACTGAGTGA |
CTAATGGCAG |
GTCACTTAGT |
AGCTGTCTCG |
ATTATCAGAT |
CAACTGTCAT |
GGTATGGCAG |
|
8801 |
TGTTTATGTT |
CAGGTACCCG |
TATTAGTTAT |
TGTTGTTAAT |
CCCTTTCTGC |
GCCCAAGTTA |
TAAACTAAAC |
TTTTTCATAG |
|
8881 |
GTATGTACGT |
ATAGGAAAAA |
ATATGCTGCA |
TATAGGCTCA |
GTACTGTATT |
TGGTTTCAAG |
CATCTACTGG |
GGGACTTGGG |
|
8961 |
AGGTACCCCC |
TGCCCCTGCC |
CCACAGGTAT |
ACTACTGTAT |
AATTATTCTT |
CTATCTAAAG |
TAAGATCTAA |
TGGAAGATAG |
|
9041 |
GAACTTTGTC |
TTGTCTTCCA |
CTCTGTCCTA |
TTTCCCAGGA |
TGATACCTGG |
CACAAAGTAT |
TTGTTTACTG |
ACAAACTAAA |
|
9121 |
AGATGATTTA |
TCCCAATTAT |
ACTCACATCT |
TCCCTTGATT |
TTCCAGAAAG |
CCTACAGGAA |
GTAAGATGGT |
AGAAAAGCAA |
|
9201 |
AGTCTTCGTA |
GAAATGCAGA |
GCATAGACTG |
GCTCTTGGAG |
AAGGTCAAAC |
ATCACCCTCT |
CCTGTGGTTA |
AATTGAGATG |
|
9281 |
GTGGCACTGG |
CTGTCTTCTA |
TATTATTGCT |
GCACCTTTCC |
TCACCAGGGG |
TGCACACAAA |
ACTGGGAGAG |
AGGGGAGGAA |
|
9361 |
GGAGCTTAGC |
TTTGTCTTAA |
TAGAAGGGAA |
GAAATGATGT |
TTTCCAAGAG |
ACCTTGAAAT |
TGGGGACCTT |
GGTAAAGGTT |
|
9441 |
TCAGTTTGGG |
AAGATAAAAA |
AGTCCTGGGA |
TGGATTCCAA |
CAGTGTAACT |
GTACTCAATG |
CCACTGAGCT |
GTACGCTTAA |
|
9521 |
GAGTGGTAAA |
TTTTATGTCT |
ATTTCACCAC |
AGTTTTAAAG |
ATTAAAATTT |
TTAAAAGTGG |
GGGAAGTTAC |
CTAGGACTTT |
|
9601 |
CTAGAAGGAC |
TTTTGAGGGT |
GAGCAAGTTC |
TGTTATAGGC |
TTGTGTATTA |
TTTTGGTATT |
TCTGATTTTA |
TCATAGGAGT |
|
9681 |
GAGGTTAAAG |
TTGTATTTTG |
ACTGGAATTT |
TTGACATTGT |
CAGGGTTTCT |
AGAGTGTGGA |
GAAGGTCACT |
CAGTATTTTT |
|
9761 |
TGTTTTTGTT |
TTTTGTTTTG |
CCTTTGTTCT |
TGTTTTCCTC |
TATTTAGGGA |
GGTGGATTGC |
CATGGGAAGT |
ACCTTTGCTT |
|
9841 |
CGAAAAGCCA |
GAAAATGCCT |
GGTAGAACTC |
CAGAAAAGTA |
GTAAGGAGCT |
GGCTTCTTCA |
GAGGCAGCAT |
AGCAGAGTGG |
|
9921 |
GAAGAGGGCC |
CTGTCACTTA |
GATTGTGACT |
GTCGACAAAG |
TCACTTAACC |
ACCAGAAGTT |
GGGTTTTCTG |
ACGTTTAGAA |
|
10001 |
TTTTGAAAAG |
ATTAAAACTG |
AGTGCCTTGC |
AAAGTACCTG |
GTATATATTA |
AGTGCTCAAT |
AAGTGATAGT |
TGCTTTGATT |
|
10081 |
CTAAGAACTG |
GTTCACCTTG |
TGAGATATAA |
TTGTGTAATG |
GAAGAATGAA |
AGCAGAAACT |
TTAGTTTCTA |
CTTTTACATT |
|
10161 |
TCCTGGGCCA |
TTTTACTACC |
CTAAATGAGA |
AGCTGGGCTT |
CCAAAACCCA |
CTTTAAAAGT |
AAAGACTAGG |
CCGGGTGCGG |
|
10241 |
TGGCTCTTGC |
CTGTAATCCC |
AGCACTTTAG |
GAGGCCTAGG |
TGGGCAGATC |
ACTTGAACTC |
AGGAGTTTGA |
GACCAGCCTG |
|
10321 |
GGCAATACAG |
CGAGACCGTA |
TGTCTACAAA |
AAATACAAAA |
ATTAGCCAGA |
CATGGTGGTG |
CATGCCTGTA |
ATCCCAGCTA |
|
10401 |
CTCGGGAGGC |
TGAGGCGGGA |
GAATTTGAGT |
CCAGGAGATC |
GAAGCTGCAG |
TGAGCCGTGA |
TTGCGCCGCT |
GCCCTCCAGC |
|
10481 |
CTGGGTGACA |
GAGTGAGACC |
CTGCCTCAAA |
AGAAAAAAAA |
AAAAAGAATA |
AAGATTAATG |
GAGATTTGGA |
ACATCTTGAT |
|
10561 |
ACTGTATCTT |
GGGAATCTAA |
GCATTGTAGA |
ATTGTGTTAT |
GTGAGTTATA |
CCATTGTGGT |
GGGAAGTTTT |
TGATTTTTGT |
|
10641 |
TTTAACTGTG |
TTGAGTTGCA |
GTTCTTAGAA |
ATGACCCGAG |
GTGTTGTCTT |
ACAAAAGAAA |
TAAACTGTAA |
TCTGTATCTT |
|
10721 |
GATCTGATGA |
GGGTATGTAA |
ATATAAAAAA |
TCGAGCTGTA |
TACTTTCTAT |
ATGCTTTATG |
TAGTTCACTA |
TATATAATTC |
|
10801 |
ATAGCTCAAT |
TAAAAAGAGA |
GAGAGAGGCT |
AAATTGTATG |
TACCATTGCA |
AAGAAATCAT |
TATCCCCAGA |
ACTGACTCAC |
|
10881 |
ATACACCTTT |
AACAGTAGAG |
GGAGAACTGA |
GGTATTAATT |
TGGAAAAATA |
ATCACTGGGA |
TAATTAATAT |
AATGCAGTGG |
|
10961 |
TTTTATGACT |
GATTTTTTAT |
TAACTTCTAT |
TTTCTTTGTA |
TTCTAGTTAA |
TAAAGGTATC |
CATGGAGAAC |
ACTGAAAACT |
|
11041 |
CAGTGGATTC |
AAAATCCATT |
AAAAATTTGG |
AACCGTGAGT |
ATTTAAATTG |
AATTCTTTAT |
AATCAGAGAA |
AGATGGGGAT |
|
11121 |
GTGTAATAAG |
CAAACCTCGA |
GCAGTGGGGC |
AAGAGGAAAG |
AGAGTGGTCT |
CTCTCTCAGG |
CCAGAGAGAC |
CAAGTGACTT |
|
11201 |
CCTACCTCAG |
ACAGCTGTGT |
GGCTTTGCAT |
AAACTGACTT |
TTCTTCTCTG |
AACCTCGTCT |
TTAACATGGG |
GCTAAAACTT |
|
11281 |
TCACAGAACT |
GAAGGGAAGA |
TGAAAGGAAA |
GGCCTAGTAG |
GGTGTGTGAC |
CCATAGTTGG |
AAACCTAGTC |
CTGGAACCAA |
|
11361 |
AAGGACACCA |
CAGGAGAGGC |
AGGACTCCCA |
AGCGCCGGTG |
CTTTCTACCC |
TCCCGAATCG |
CTCTATAGGA |
TTAGAGGGTT |
|
11441 |
TAGGTTTGGG |
AGGAGTTTCT |
TGACCTCTTG |
TTTATGAGTT |
TTTACGACTA |
AAATGCAATG |
CCAGTTTTCA |
GTCCGGGGAC |
|
11521 |
AAACTGCCTA |
GTTATGGATG |
AATTTTACCC |
TTTTTTTCCC |
CGTGTCTTTT |
TGGAATATTC |
TGCTTATTAA |
TGCTTCCAAT |
|
11601 |
AACTAGCAGA |
TGGAAAAAGG |
AAAAAGATAA |
AACTCAAATT |
CACTTTTTAA |
TTCTTGTCTG |
TTATTATTTA |
TTTGGGATCT |
|
11681 |
CTCGTAATAC |
TTTAAATTCT |
GAAAGTTTAT |
TTCTGAAACC |
CAGTATTGTT |
ATTCTCGGCT |
GCCCTGAATA |
TTACAAACTA |
|
11761 |
ATTTTATTAC |
TAAACAATAT |
GATTACAGAA |
ATACTATTAA |
CAAGTTACCA |
CTAAAGATTT |
CACAATTTTG |
TTTAGCAAAG |
|
11841 |
GGATTTTTCT |
AGAAAGTAAA |
CTTTTAAAAT |
GCAGTCCCAT |
TTTAGAGAGT |
TGTTGCTGTC |
ATTTAAATCA |
TTTTAGCCAG |
|
11921 |
TGCAGTGGCT |
TGCTCCTGTA |
ATCCCAGCTA |
CGTGGGAGCT |
GTGGCAGGAG |
GATCACTTGA |
GGTGGAGAGT |
TTGAAACCAG |
|
12001 |
CCTGGGCAAC |
ATAACGAGAC |
CCTGTCTCTA |
CAAAAAAACA |
AAAAACAATT |
AGTCCACCAT |
AGTGTGTGTG |
CTTGTAGTCA |
|
12081 |
GTCCTAGCTA |
CACGCCAGAG |
GTTACAGTGA |
AGTAAGACCC |
CATCTCTTCA |
AAAAAATCCT |
TTGAAAGTGA |
TTTACACATT |
|
12161 |
TTCCTACTAT |
TTTTTTTTTC |
TTTCTTTTTT |
GAGACAGGCT |
GGAGTGCAGT |
GATCTGATTA |
TGGCTCACTG |
CACTCCTGGG |
|
12241 |
CTCCAGTAAT |
CCTCCTGAGT |
AGCTAGGACT |
ACAGACATGT |
GCCACCATGC |
CTGGTTATTT |
TTGTTTTTTA |
TTTTTGTAGA |
|
12321 |
GATGGGGGTC |
TTGCTGTGTT |
GCCCAGGCTG |
GTCTCCAATG |
CCTGGCCTCA |
AGGGATCCTC |
CTGCCTCGGC |
CTCCCAAAGT |
|
12401 |
GCTGGGAGTA |
CAGGTGTGAA |
CCACCCTGCC |
TGGCCCTACC |
TTTTCATGTC |
ATGCAGAACA |
CCACTTCAAT |
AACAAGTTGC |
|
12481 |
ACGGAAGCCC |
CAGACAGGTT |
TAGGGTTGTT |
TCGATCCTTT |
GGTAAGTTGC |
CCTCACAGTC |
CCGGCTTTCA |
CAGCCTCTGC |
|
12561 |
CTTTTATTAG |
GAGTATCCCC |
TCGTGGACTA |
GCTATCATAT |
GCTTGTAAAG |
TACCTACCTC |
CTTAGGAGGC |
ACCCAGAGCA |
|
12641 |
CGTGGGGAAG |
GGGTGTCGGG |
AGCTGGGAGT |
CATAAGTCCC |
ATGATCCATC |
ATCTGTAGGA |
CTCAAAGGTC |
AAGTCACGCT |
|
12721 |
TTCAGGATTT |
AACTTCAGTC |
TGTAAATGTG |
AGGCTGTTCA |
CCTCTGGTTA |
AAAATCATAA |
CTGTTTTCTC |
ACGTTGACTC |
|
12801 |
CTTTAATTTA |
CTACATTTAA |
TCTTTTTCCA |
ACAGTATTTT |
TGGAATTGTG |
TATAATGTGA |
GATGCTCTTA |
AGGTTAAGTG |
|
12881 |
CATGAGTATA |
TGGACTGTAG |
GTGTTAGTGT |
TTGGTAGTTC |
CTAGACCTGT |
TTTTGCCTGA |
CTCTTGGTCT |
AGATCAGGGA |
|
12961 |
TCAAGCTTAA |
GGCCTGTTTT |
TATCAACTTT |
CGTTGGAATA |
TAGGCACATC |
CATTCGCTTA |
CATATTGTCC |
TAAGCCCGTT |
|
13041 |
TCACCAGTAT |
AATTGAGCAG |
CTATGGCTGG |
GCACAGTGGC |
TCACAACTGT |
AATCCCAGCA |
CTTTTGGAGG |
CCAAGGCAGG |
|
13121 |
AGGATCACTT |
GAGGCCAGGA |
GTTCAAGACT |
AGCCTGGGCA |
ACATAGCGAG |
ATCCTGTCTC |
TAAAAAAGAA |
AATACAGAAA |
|
13201 |
TTAGCTGGGC |
ATGGTGGGGC |
ATGCCTGTCT |
GTAGTCCTAG |
CTACTCAGAA |
GGCTGAGGAA |
GGAGTATCAC |
TGGAGCCCAA |
|
13281 |
GAGTTCAAAG |
TTGCAGTGAG |
CTATGATGGC |
ACCACTGCAC |
TCCAGCTTGG |
GTGACAGAGC |
CAGACCATGT |
CTCAAAAAAA |
|
13361 |
AAAAAAAAAG |
AATAGAATTG |
AGTAGCTGTA |
ACAGAAACCA |
GATGGCCCAC |
AAGCCTAAAA |
CACTTAATAT |
TTAGCCCATT |
|
13441 |
AAAAAAAAAG |
TTTACTGACC |
CCAATCTAGA |
TAGCAGAGGT |
TTTTTTAGAT |
AAGTGACTTC |
CAGACAGATA |
TTTTCAATTA |
|
13521 |
TTTACAATAA |
TGCTTTTATA |
TATTAATAAA |
TTACTAATTT |
GTTTAGCTCA |
TGGGGTTTAA |
GGAATAATTT |
ATGAATTGTG |
|
13601 |
ATAAATATTG |
TGCTTTGAGT |
TATATTTGCA |
TTTTGTTGAT |
TTCCCATCAT |
TTCAGGGTAA |
TTTTTAAGAT |
TTTTACTCTT |
|
13681 |
ACCTCAAAGG |
ATAAAATATT |
TCACAAAGTT |
AATAAGTAAT |
TTTTAAATTA |
TAAAGGTATT |
TGATGAAATT |
TTGAAGAATT |
|
13761 |
TAGAGGAAAA |
TGTAAAACAT |
GGAAGTTAAA |
AGCCTGAACT |
CTGAAGTCCA |
ACAGATGCTT |
TCCTTCCTTC |
TTGGCTGTGA |
|
13841 |
CACAATATTT |
GCATAACCTT |
TAGCACATTA |
CTTAGCCTCA |
CGTCAGGTCA |
TTTTCTCATC |
TGTATAACTG |
TTGATGTGAA |
|
13921 |
ATTGAAATGA |
AGACAGCCTG |
GTTTATAACA |
TTCAACAAGT |
GTTAACTGTT |
ACTGTGAGTT |
ATAAAAATTG |
CACTAATATA |
|
14001 |
AACAGAAGGC |
GTGGTCATTT |
CTACCTTTGT |
AAAGCTATTA |
TTTGATTTCT |
AAACAGAAAG |
ATCATACATG |
GAAGCGAATC |
|
14081 |
AATGGACTCT |
GGAATATCCC |
TGGACAACAG |
TTATAAAATG |
GATTATCCTG |
AGATGGGTTT |
ATGTATAATA |
ATTAATAATA |
|
14161 |
AGAATTTTCA |
TAAAAGCACT |
GGTATGTGTC |
TTACATAATT |
TTTAATCCTT |
TTCAAATGTT |
TGTGCCATTT |
ACATTTGATA |
|
14241 |
TAATATTAAA |
AGCAGTATTA |
TTGAGGTATT |
AGACAGTAAA |
CCGTGACACA |
GACTAGCTGT |
GAAGTAGAGA |
TTGGGCAGGA |
|
14321 |
CCTACAGGTC |
CTCTGATACA |
CTGTGAACGC |
GTCACTCTTC |
TGCCCAACTT |
CATAGCCTCC |
TCTTGCTGGC |
CTCCTATCTG |
|
14401 |
TATGCTTGGT |
TGCCTCTGCC |
CTGACTTCTC |
TGTAGCCCTT |
GCTTCTTTTT |
CTTCTTTCTG |
CTTCCTCTTT |
GATCCCAATG |
|
14481 |
GAAGGTTCTC |
AAAAAAACAG |
TTAAGTGGTA |
GTATTTATTT |
TTTCCCCAGA |
AACTGCAAGA |
GATATCACAA |
GCATTGCCTT |
|
14561 |
ATTTAATTTA |
TGACAACCTG |
GAAAGTAACG |
ATGAGATTCT |
GAAAGGTTAA |
AGACCTCGCG |
CAGTCACACA |
GTATGGCGGC |
|
14641 |
AGAGCTAGGT |
CTGTGTGGCT |
CCAAAGCCCA |
AGCTCTGAAT |
CCATCTTCTG |
TTCTGCTTCA |
CTTCCTTGTA |
TCCTCATGTG |
|
14721 |
CTCTGTTGCC |
TGTCTTCCCT |
TACCCTACGA |
AGCTCCCCAT |
CTTAGAGAGA |
CCTTTCTTTT |
ACTCTGTTCC |
TTTTGATTCC |
|
14801 |
TTTGATATTT |
TGTCTCCTTC |
CCTTCTTCCT |
TAAATTTTGA |
ATACATGTAG |
TTTAAGCTTG |
TACTCTTCAT |
TTGTTTCCAT |
|
14881 |
TCCTTCTTGA |
GTCTTTTTCC |
ATTTTCTGTC |
TCTACTACTA |
AAACTGCTTG |
CTTTAAATTT |
ACCATGGCCT |
TGCCACCAGA |
|
14961 |
TCCCCCTCTC |
GATTTCTGTA |
CTATGTACAA |
CTTGAATGTA |
GTACTACATT |
TGAGAATGTT |
TTTTTAGAAA |
TATAGATAAT |
|
15041 |
AAAATCCTTC |
ACAGTGCCAA |
AAAAGCTAAT |
TAATATTTGG |
TGTATTGTTA |
TTTTTTCTTG |
GCAGTTCTTT |
TTAAAGCTTG |
|
15121 |
ATTTTATTCA |
TAACGTATAA |
GCAATGTTGT |
CTTCTGCTTG |
TTTCACTTAA |
AGGAATAGCA |
TTTTTCATAT |
TGCTGCATAA |
|
15201 |
TTTTCATATC |
TGTTATAATG |
ATTATATAAT |
ACTGCATCCC |
CAAAACTACC |
ATTCACTTAA |
TTTGAATAAT |
TTACTGTATG |
|
15281 |
AATGAACATT |
ATGGCTGTTT |
CCCTTTTAAA |
TTGATGCTAT |
GATAATTCTT |
TGAATTGGCC |
TATTAATCAT |
ATTAGAGTTA |
|
15361 |
ATTTTTAATT |
AGAGAAGCTG |
TAGTAGATCT |
AAGGTGGGCC |
AGTACCTATC |
AGAGTGGTGG |
TGGAAATGGA |
AGGAAGCCAG |
|
15441 |
ATTACACTGG |
GAAGATAGCA |
GGGTTTGTGT |
CAGATTAATT |
ATAAGGAGTG |
AGAAGAGAAT |
AGTTGAAAAT |
GGAGCTCTAA |
|
15521 |
ATGGCATCAG |
TTTTATTGCT |
TTTGGCTATA |
AGTTGAGATG |
CCACCTTCAA |
CCATTAACTT |
AAAAACACAA |
CACCTTGTTT |
|
15601 |
ACTTTTGCTT |
TACGCATATT |
TGAAAATTTA |
CTTCTAGATA |
TTCTGCCTCA |
CATTTCTAGT |
TAGGATACCT |
CCTTCCTATA |
|
15681 |
GAATTTTGCA |
CTGTTGGCTC |
TATTGTTTCA |
AAAACCAAAA |
ACAAGCATAT |
TATTCCACTA |
CCACCAGCAC |
CTCCCCCCAC |
|
15761 |
ATATTTAGAC |
CAGCAGTCTG |
GGTTTTGCCC |
AGTGAGCTCC |
TTTCCTACTT |
TGCAATGTAA |
AGGTCAGGTT |
CTCATGAGAT |
|
15841 |
CTCTGGCAGG |
CTGGTGTTGG |
GCCAGGCGCC |
ATGGCTCACA |
CATGTAATCC |
CAACACTTTG |
GGAGGCCAAG |
GCAGGAGGAT |
|
15921 |
CCTTGAGCAC |
CAAAGTTCAA |
GATCAGTCTG |
GGCAACACAG |
GGAAATCCCA |
TCTCTACAAA |
ACAGAAAAAA |
GGTAGCAGGG |
|
16001 |
TGTGGTGGTG |
CGCACCTGTA |
GTCCCAGCTA |
CTCGGGAGGC |
TGAGGTGGGA |
AGATAGCTTG |
AATCTGGGAG |
GTTGAGGCTG |
|
16081 |
CAGTGAGCTG |
TGGTTGCTGT |
ACTCTAGCCT |
GGGCCACAGA |
GCAAGATCCT |
GTCTAAAAAA |
TAAAAATAAA |
TAAAAATTAA |
|
16161 |
AAGGCAGCCA |
ACACATCAGC |
ACCAGAAGCC |
AGTGACCTTG |
TCACACAGCT |
GAGATAATCA |
ACAACATTTT |
GGAGATACAT |
|
16241 |
GTAGACTTTC |
TGTATTTAAT |
CTTCATACCC |
ATCAAATTTA |
CTCAATTCTG |
AGGGATGTTT |
CCCACCAAGA |
TTTAGCATTT |
|
16321 |
TGAAATCTGA |
GTGCATCATG |
CAGTCAATCT |
GTACGTTAAT |
GTGGAAGGTT |
CTCTAAAGGA |
GTGGTAGAAA |
GCCCAGGAGC |
|
16401 |
CCTGGATACA |
GGCCCAGCAT |
AGCTTTGTCA |
CTTTGGACTG |
GTTTGTTAAC |
TCTGCTACAT |
GTCCCACATC |
TGCACAAGTG |
|
16481 |
AAACTAGTAA |
TAATATGACT |
CTCATGGTGA |
TTGGAAGGAT |
TAGAGATTAG |
CCATAGCAGA |
ATACCTGATG |
AACAGTAATA |
|
16561 |
ATGTTTGGGG |
GTTTTCCTTG |
AAGGCACTAT |
AAATGTTGTA |
ATGCTATCTT |
AAAATTGTTG |
GGAAGTTAGA |
GTCAGAGAAA |
|
16641 |
CGCATTTCCT |
CTGAGTGTGA |
CAGATGTGTG |
TATGTATTAT |
AGGATCGTAT |
TGTTTTCTAG |
TCTTATTTTT |
TTAAACTGAT |
|
16721 |
GATTTTCCCA |
TGGCAACATT |
TTATCTGTGA |
AAATGACAAC |
ATAGTATATC |
CCATTATATA |
AGTTAGTATA |
GCTTGTCTAA |
|
16801 |
CCAAACCCTT |
ATTGTTAGAC |
ATTTGTGTTT |
TTCACTACCT |
AAACCGCTGT |
GAAAGACATC |
ATTTTGGCTA |
TAACACTGAT |
|
16881 |
GAGCTTATAT |
TATGAAGTAT |
CTTATAAGCT |
ACAAAATTGA |
AGAAATTTTG |
TTCACCATGT |
TCAAAATAGT |
TAGAATTCTC |
|
16961 |
TTACCATTTA |
AAAGGAAGAA |
TTTATTGTGG |
ACTTCTGAAT |
TGCTGAGTAG |
TTAATTTCAT |
TTCAAAGTAG |
TTATTCTTTG |
|
17041 |
TTTTCCATAC |
AATTAAAAGT |
AATTCTTTCT |
GTTCCAAGGA |
ATGACATCTC |
GGTCTGGTAC |
AGATGTCGAT |
GCAGCAAACC |
|
17121 |
TCAGGGAAAC |
ATTCAGAAAC |
TTGAAATATG |
AAGTCAGGAA |
TAAAAATGAT |
CTTACACGTG |
AAGAAATTGT |
GGAATTGATG |
|
17201 |
CGTGATGGTA |
AGAAGAAACA |
ATTAGAATGA |
ACTTCATTGT |
ACAATTAATT |
TTATACTATG |
GTCTAGCAAT |
AATTATATGT |
|
17281 |
ATAATAAAAT |
ATGAGAATTG |
TGGAATTATA |
CTGTACATAA |
CCCTAATCTT |
ACATACTTTA |
GTAAGAAGTT |
TAAAAAAAGT |
|
17361 |
TATTTATGCC |
AACTTCCTAA |
AATGGTTTGA |
GATGTGTTGC |
CGTGCCCCAG |
GTTAGGTTAA |
GATGACCTCT |
TAGTTTTAGT |
|
17441 |
CTCAGTTTCT |
TCATCATGTT |
CCCATACAGT |
ATATCTGAAG |
TTGTTGAATA |
AAGTCATGGA |
TTTTTTTTCC |
TTTTATTTGC |
|
17521 |
AAATGTCTTT |
ACAGTTTCTA |
AAGAAGATCA |
CAGCAAAAGG |
AGCAGTTTTG |
TTTGTGTGCT |
TCTGAGCCAT |
GGTGAAGAAG |
|
17601 |
GAATAATTTT |
TGGAACAAAT |
GGACCTGTTG |
ACCTGAAAAA |
AATAACAAAC |
TTTTTCAGAG |
GGGATCGTTG |
TAGAAGTCTA |
|
17681 |
ACTGGAAAAC |
CCAAACTTTT |
CATTATTCAG |
GTAATGTCTA |
ACTGAGTGAT |
TTGGTTATTG |
ACGATTAAGC |
AGGGGTTACT |
|
17761 |
ATTCTCAACT |
GTAAATTATC |
CAAAGGATAA |
TTTTTTTCCT |
GAAGCTAATG |
AACTATTGTT |
ACTTTTCATT |
TATTTACCAC |
|
17841 |
TTAAAAGATA |
TAGAGTAAAT |
TTTAATTTTA |
TACTTATATC |
AAAAAGACTC |
AGCATAATTA |
ACATCCTTTT |
TTTTTTTTTT |
|
17921 |
TTTTTTTTTT |
TTAGACAGAG |
TCTTGCTCTG |
TCGCCCAGGC |
TGGAGTACAG |
TGGCGCGATC |
TCCGCTCACT |
GCAAGCTCTG |
|
18001 |
CCTCCTGGGT |
TCACGCCATT |
CTCCTGCCTC |
AGCCTCCTGA |
GTAGCTGGGA |
CTACAGGCGC |
CTGCCACCAG |
GCCCAGCTAA |
|
18081 |
TTTTTAAATT |
TTTTTTTAAT |
AGAGACAGGG |
TTTCACCATG |
TTAGCCAGGA |
TGGTCTCGAT |
CTCCTGACCT |
CAAGTCATCC |
|
18161 |
GCCCGCCTTG |
GCCTCCCAAA |
TTGCTGGGAT |
TAAAGGCGTG |
AGCCACCGCG |
CCCGGCCAAT |
TAACATCCAT |
TTTTACATAG |
|
18241 |
CATTTCAATT |
TTTTAGAACT |
AAGTTATGTG |
TTCACACACA |
AATTTTTATA |
AATAAATATT |
TATTTTCTAA |
CACCCAGGCC |
|
18321 |
TGCCGTGGTA |
CAGAACTGGA |
CTGTGGCATT |
GAGACAGACA |
GTGGTGTTGA |
TGATGACATG |
GCGTGTCATA |
AAATACCAGT |
|
18401 |
GGAGGCCGAC |
TTCTTGTATG |
CATACTCCAC |
AGCACCTGGT |
GAGAACGTTA |
CACATAATGA |
ATGTTACATG |
TGGATTTTAA |
|
18481 |
ATGAATTAAC |
TGTGACTGAT |
CATAGAATTA |
TACAATGAAA |
AGTGTGTTTC |
AGAGACTGTC |
AAGATTTTGA |
TATCCCTAAA |
|
18561 |
GATATCAAAA |
CTTGTCTATA |
TTTTAGGGAA |
CCTTCATCAA |
AGAGAAGTCT |
CAAAAAGTTG |
TCTTTAGCCA |
AAAGTTTGGC |
|
18641 |
TAGAAAATAT |
GCATATATAG |
CCAGGCACAG |
TGACTCACGC |
CTGTAATCCT |
AGCGCTTTGG |
GAGGCCGAGG |
CAGGTGGATC |
|
18721 |
ACTTGAGGTC |
AGGAGTTCAA |
AACCAGCCTG |
GCCAACCTCA |
TCTCTACTAA |
AAATACAGAA |
AAATTAGCTG |
GGCATGGTGG |
|
18801 |
CACACGCCTG |
TAATCCCAGC |
TACTGGGGAG |
GCTGAGGCAG |
GAGAATCGCT |
TGAACCTGGG |
AAGCAAAGGT |
TGCAGTGAGC |
|
18881 |
CAAGATCGCA |
CCACTGCACT |
TCAGCCTGGG |
CGACAGAGTG |
AGACTCCGTC |
TCAAAGGAAA |
AAAAGAAAAG |
AAAATATGCA |
|
18961 |
TATGTAGAGT |
AGACTAGCAC |
GATGTCATTC |
ATTGGACTTT |
ATCAGGTAGA |
TCTCCGCTAC |
TAATATCAGG |
TAGAATATTA |
|
19041 |
CGTGGCAACA |
GAGGCCAAGT |
CAGAGCTTCC |
CCTGCATCTT |
AGAGAAGAAG |
AGAGGTACGT |
TTCTCAGGAG |
TTATTTGAAA |
|
19121 |
GGTAGTAAAT |
AAAAAAGATA |
AACATGACTA |
GTATACAAGA |
GGATAGATGT |
GGAGTGGGAG |
AAAAGAAGGT |
AAAAAACGAT |
|
19201 |
ACATGAATGT |
GCCGTTAACC |
TCCACGTTTT |
TACTGTTCTG |
CTGCACACGT |
CATCATCTAA |
ATAAACATTT |
GTGGATTATA |
|
19281 |
CCACCATTTA |
CTCACACAGC |
TAAGGGTGTC |
GGAGAGTTTG |
GAAACTTTAG |
GTAAATGTAT |
TCTTAAGCAG |
TGTTGCATTT |
|
19361 |
TAAAATATGC |
TCAATATGGT |
TTATCTTATC |
CTCTAGGCAT |
CTTTCCAAGC |
AAAGTACCTC |
TAAGTTAAAA |
GCAATGGGTC |
|
19441 |
TAATAGTTAA |
CCTAGAAAAA |
AAAGTATGAT |
AAATATACTA |
TTTTCCCTTT |
TTGGACCAAT |
ACTTGGTAGT |
GTGTTTATTA |
|
19521 |
TACTTTATTC |
AGATGCTCTG |
TAGACAAGTA |
GGACACTCAA |
AGCAATTTGT |
TTCTTGGCTA |
AGTCAGTATT |
AAAATAAGGT |
|
19601 |
GAAATCTGAT |
TGGAACACTG |
TGCTACTTAC |
AATGATCCTT |
TTTATACATC |
TTTACTTTTG |
CATCTTACCT |
TCTGCGTGTT |
|
19681 |
TGCTCTTCTT |
GCCTATTGAA |
AGGGGAGTCC |
AGAAAGTAAA |
ACTTTCAATA |
ATTCAGTGTT |
CGTGAAGCTG |
GTCCCCGGCC |
|
19761 |
AGCTTTGCTG |
AAAGCAGGGG |
GTGTACGCAT |
AGCACACATT |
CGTCCTTCAG |
CATCATTTCT |
TCTGAAACCA |
AAGGTGTCTT |
|
19841 |
TTTTTTTTTA |
TTTGTATGAC |
TAATAAGACT |
TATGTAAGTT |
TATGCTTATT |
TTTGCCTTTA |
TGACTACATA |
ATAATTTATA |
|
19921 |
GAATCAACTA |
AAATCAGCTA |
TCCATGGTAT |
TTTGCTTGTA |
TTTTGCCTTT |
TAGGTTATTA |
TTCTTGGCGA |
AATTCAAAGG |
|
20001 |
ATGGCTCCTG |
GTTCATCCAG |
TCGCTTTGTG |
CCATGCTGAA |
ACAGTATGCC |
GACAAGCTTG |
AATTTATGCA |
CATTCTTACC |
|
20081 |
CGGGTTAACC |
GAAAGGTGGC |
AACAGAATTT |
GAGTCCTTTT |
CCTTTGACGC |
TACTTTTCAT |
GCAAAGAAAC |
AGATTCCATG |
|
20161 |
TATTGTTTCC |
ATGCTCACAA |
AAGAACTCTA |
TTTTTATCAC |
TAAAGAAATG |
GTTGGTTGGT |
GGTTTTTTTT |
AGTTTGTATG |
|
20241 |
CCAAGTGAGA |
AGATGGTATA |
TTTGGTACTG |
TATTTCCCTC |
TCATTTTGAC |
CTACTCTCAT |
GCTGCAGAGG |
GTACTTTAAG |
|
20321 |
ACATACTCCT |
TCCATCAAAT |
AGAACCACTA |
TGAAGCTACC |
TCAAACTTCC |
AGTCAGGTAG |
TTGCAATTGA |
ATTAAATTAG |
|
20401 |
GAATAAATAA |
AAATGGATAC |
TGGTGCAGTC |
ATTATGAGAG |
GCAATGATTG |
TTAATTTACA |
GCTTTCATGA |
TTAGCAAGTT |
|
20481 |
ACAGTGATGC |
TGTGCTATGA |
ATTTTCAAGT |
AATTGTGAAA |
AAGTTAAACA |
TTGAAGTAAT |
GAATTTTTAT |
GATATTCCCC |
|
20561 |
CCACTTAAGA |
CTGTGTATTC |
TAGTTTTGTC |
AAACTGTAGA |
AATGATGATG |
TGGAAGAACT |
TAGGCATCTG |
TGGGCATGGT |
|
20641 |
CAAAGGCTCA |
AACCTTTATT |
TTAGAATTGA |
TATACACGGA |
TGACTTAACT |
GCATTTTTAG |
ACCATTTATC |
TGGGATTATG |
|
20721 |
GTTTTGTGAT |
GTTTGTCCTG |
AACACTTTTG |
TTGTAAAAAA |
ATAATAATAA |
TGTTTAATAT |
TGAGAAAGAA |
ACTAATATTT |
|
20801 |
TATGTGAGAG |
AAAGTGTGAG |
CAAACTAACT |
TGACTTTTAA |
GGCTAAAACT |
TAACATTCAT |
AGAGGGGTGG |
AGTTTTAACT |
|
20881 |
GTAAGGTGCT |
ACAATGCCCC |
TGGATCTACC |
AGCATAAATA |
TCTTCTGATT |
TGTCCCTATG |
CATATCAGTT |
GAGCTTCATA |
|
20961 |
TACCAGCAAT |
ATATCTGAAG |
AGCTATTATA |
TAAAAACCCC |
AAACTGTTGA |
TTATTAGCCA |
GGTAATGTGA |
ATAAATTCTA |
|
21041 |
TAGGAACATA |
TGAAAATACA |
ACTTAAATAA |
TAAACAGTGG |
AATATAAGGA |
AAGCAATAAA |
TGAATGGGCT |
GAGCTGCCTG |
|
21121 |
TAACTTGAGA |
GTAGATGGTT |
TGAGCCTGAG |
CAGAGACATG |
ACTCAGCCTG |
TTCCATGAAG |
GCAGAGCCAT |
GGACCACGCA |
|
21201 |
GGAAGGGCCT |
ACAGCCCATT |
TCTCCATACG |
CACTGGTATG |
TGTGGATGAT |
GCTGCCAGGG |
CGCCATCGCC |
AAGTAAGAAA |
|
21281 |
GTGAAGCAAA |
TCAGAAACTT |
GTGAAGTGGA |
AATGTTCTAA |
AGGTGGTGAG |
GCAATAAAAA |
TCATAGTACT |
CTTTGTAGCA |
|
21361 |
AAATTCTTAA |
GTATGTTATT |
TTCTGTTGAA |
GTTTACAATC |
AAAGGAAAAT |
AGTAATGTTT |
TATACTGTTT |
ACTGAAAGAA |
|
21441 |
AAAGACCTAT |
GAGCACATAG |
GACTCTAGAC |
GGCATCCAGC |
CGGAGGCCAG |
AGCTGAGCCC |
TCAGCCCGGG |
AGGCAGGCTC |
|
21521 |
CAGGCCTCAG |
CAGGTGCGGA |
GCCGTCACTG |
CACCAAGTCT |
CACTGGCTGT |
CAGTATGACA |
TTTCACGGGA |
GATTTCTTGT |
|
21601 |
TGCTCAAAAA |
ATGAGCTCGC |
ATTTGTCAAT |
GACAGTTTCT |
TTTTTCTTAC |
TAGACCTGTA |
ACTTTTGTAA |
ATACACATAG |
|
21681 |
CATGTAATGG |
TATCTTAAAG |
TGTGTTTCTA |
TGTGACAATT |
TTGTACAAAT |
TTGTTATTTT |
CCATTTTTAT |
TTCAAAATAT |
|
21761 |
ACATTCAAAC |
TTAAAATTAC |
|
|
|
|
|
|
|
|
|
|
|
|
>ref|Gene_ID:836|CASP3|NC_000004.11:185548849...185570628 (-)
CATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAAG
GTATGAGGAGGCTGTGCGGTGACTGCCGCCCTCGCTCCGGGCCGTCAGCCCTGCCCCCGCTCCCTGCGTTCTCCCAGGCC
CTGCGCCCGCCCGGGTACCTGCCCGGTCTGGAAGGCGGAGTGTTTGTTTTGCCACCTCGCCCGGGCGGGGGCGAGCAGTG
AAGCCCGCGGAGCGAGAGACTTGGCCCGGAGGCGGGAGCCTGGGCCGGGGCCGGGGAAGCCAGGCAGCGGGTTAAGGCTT
TTGATTTAGGGAGAGGGACCTGGGGGTAACCTAAGGAAAGGCCTCAGGTCATCGGAGGGGAGACCTGGCCCGGGGGCGGG
AGGCTGGGCTGGGACCGGGGAGGCCGGGCAGCGCGAGGCCGGGCCGGGGAGGCCAGGCAGCGGGAGGCCTGGCCAGGGGA
ACCGAGCCCGGGGCCGGGAGGTCGGGCACGGGGCACCGAGCTCCGAGGGCGGGAGACCTGGCGGCCGGCCGAGTGCCGGA
AGGCCGGGTCAGGCGGCGGAAGGCAGCGGCAAGCTGGGAAACGGACGGCGCTACCGCCGGCGGAGGAGTGGCCCCGGGAA
GCGGTGCTGCGAGGGCTGGGGCGGCCGGGTGCTGACTGTGAGATACTCGCCCTGGGGGCTGATCCTTCCAATTTTGGACG
AGGCTTCCGTCTCTGCTGCCTTCCATGCCTGGGGCCTGGATTATCCCGGGTTGACAATGTGGTTTAGCTCTTCCAGAGAG
ATAGTTGCAGGGTTTAAACTCCAATTCCTTTTCGGCCCTGCAGAGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGT
GTATCCGTGGCCACAGCTGGTTGGCGTCGCCTTGAAATCCCAGGCCGTGAGGAGTTAGCGAGCCCTGCTCACACTCGGCG
CTCTGGTTTTCGGTGGGTGTGCCCTGCACCTGCCTCTTCCCCCATTCTCAGTAAGTGGCACCCAAGCAGGAAACCGGAAA
ACATCGTTCGCAGCCCCCTCTCGCCCACCCACTTCTTTTCCTGCTTAGTCGCCAAGCCTTGTCGACCTTGTAAATGTCTG
CCAGATCTGTCCGCGTCTCTCTATCTCTGATTTCAGCCGTCTGACCACAGCAGCCTCTTCCCTGGTCTCTCCACTTCCAG
ACCCGCCTGCTCCTTTGCAGTCCACTTTTTACAGCACAGGCAGAGGGATCTTTATGAAATGAAAGTCTAGAAAGCTCGTC
CTTTGCCCTTAGGTTAAACCCAGCACTTAATATGGCTAACAAACCCCTGCGTGTGTTGGGTCCTGAGTGCCCCCACCCCT
CCTTATCTTTAGCACCGGTTCGATTTCTGCACGGCAATGCTGACCTTCATACCTAGTGTCTGCCTGCAACACCTCTGCAC
TCCCTTTCTCCCGCCATCACATTTGATTAGAAGAGCTGCTACTTAAATTTCTGTTTTCATTAAACAGTTTAAGGTTAAAT
CTTCCTATGCTGTGTTCTTTCTGCAGCCAGCATTCCCTAAGAGAGATGTGTCATATCCTTTGCAGTTGCTTGTTTACTAT
CTTCCCTGCTAGATTTGCAAGCAAACTCCAGGAGGGACGGACTTGGTTTATCTTGGTATCCTTAGTGTCTTGCCCCAAAT
GCGGGGCCTGGCATAACACAGTGAATGCCCATCCATTGTATTTTTACTTTTATGCCCTATCTAGAAAAAGTAGACCTGGT
TTAGGATTATTCAGCAAATAATAATTAGAAAAGAAATGGTAGAGGTGACATACGGAGTCACTGAAACGATGTAAACCTGC
AAGATAGCTGAAAGAGGGCCAGGCAAGGTGGTTAGACCAGACTGTATCAAAATGGGCTCAGCCACTGTGAATGTGCGTGC
TGTGGTTACATAATCTCTAAAAATGAAATATAAAGCTTAAATCATCTCTATCACAGCCCGATGCTTGGACTTTGGTTTTG
CTTTGCCTTTTTGCAAAAGAAGGTTTTTGAAAGTGAAAATTATTTTAGTGAATGGATGAACAGTTTATTGGAGTATGGCA
ATAAAACCTGTTCAAAGTAAGAGACATTAGACATTGTACCTAGTTAAATCAGATTTGCTTTTGCTATCCTGAATAAAGGC
CTTGCCTCTTGCCATTTGAAGAGACTGGCATCTGATATAGGCAATTATAATGCTTCTTTACTGTTTTGTTTTCAAACCTC
GTTTAACACAATCTCCTACTGCTTCATCCCCCTACAAAGCAGTCTTTATTTTGATGAATGATATATTACATTGCTTCTGG
TGCCTACTATTAGATCTTTAAGCTCTGCCCCAAAGATAAGAAGCACTGGTGTTTGGGCCTAAACAAAGATGGGAGAATTC
TTAGATTTATATAATATTCTTTCTCTGCATGTTTTGTTCTTACCTTCACATGTTGCCTGTAGAGCTTCTTTGCATTACAA
TAATGAAATCAAGCTACCTGATATGTATTGGACACGGTCTGGCATCTGCCTTGTTGAGCCACTTTTGAATACCAGTGAGC
ATCGGTATAAGCCCTGAATAGAGATAGGGTTTGTCTCTTCCACTGCTTGATACACTCAGGGTCTAGTATAGTACTCTGCA
CACAGTTGGTGTTCAGTAAATTGTTATGGTGCAAATATCAAATGAATAAATGCTACTGAATCTGAGTTTTGGCAGTTTCA
GTCTTCCTGACAGCAGGATTTCTTCAAGCGGTTTTAAACTTGAATCTGATTCTGCAAAGTAGTCATCCTTGGTGGGAGTG
CTGAGGCTTTAAAGTCATCTGTAATTTTTATAAAAAGGCATCCGAGATCCTCCATTTTACACTTATATCATACAAATCAT
TTAGATCTGTGAAGGCTTTCCCATTTTCTCCTTTTGTCCTTCCAAAAACACCATCTTAGGACTTCACCTGGCACAGGGAA
GACAGATCGTTTGCACATACTAAGTGCCCTTCTTTCTAACTTGTGTCATAAACTCAGAGGCTTTGAATAGTGGAGAGTGC
TCTGTACTGTCTTCCTGGTCACGTGGCCCTTGCCAGAGGAAAGGAAAGGATGGTTTGTTTGTATAGTACAATGGAACTTA
TTTCAATGTATTCTGTATTTGATTTTACATTCCTGTTCTCATATTTTTACCTTAATTACATAACAAATATTAAAAGATTG
ACTTCACCAGGCCCAGTTACAATCGCCAGTTTGATAATTCTTATACGTACTCAAATGAATTCAGAGACCAGATGGGAAAA
GATTTTGATAAAACCTCTGGTACATCACAACTGAAGTCTTTTCTTGTCCAAACTATTGTGAAACAGATGTTCTTTCTGTT
TCATTTGCTAAATCTGGAAACGTGACTGCTTTTGAGACTTTGTCCTCTCTGACAGGTAATAAATATAATCCTGATATTTT
TCAAGTTGTTTGACAGAAGTGTAATCTCCCCAGAAGTCCTGCTGGACAGGCTTCACTTTTCCTTTGGAGGAACACAGAGA
TACAGGGAATATGTTTTAATGACATATACCTAACGCTGAACATGAAACCAGTTATTTTACTTTTATTATTATTATTTTTA
GAAACAGCCTTGCTGTGTCACCCAAGCTCAAGTGCAGTGGTGCGATCATAGCTCACTGCAGCCTCCAATTCCTATGCTCA
AGTAATCCTCTTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCATGCCAGGCTACTTGTTTTTACTTT
GTTATAGAGATGGGGTCTCTCTGTGTTGCCCAGACTGGTCTTGAACACATGATCTCAACCATTCCTCCCACCTTGGCCTC
CCAAAGTGCTGGGATTACAGGCGCGAGCCACTGTGTCTGGCCTATTTCACTTTAGAAGTAAATTGAATGCCACATGCGAA
GTTTGTTAAATTTTTTTAAAAAAGGAAAGAAAACACAAAAGTAAACTACCTAGTCGCATCAGAAATGCCATAGTCATTTT
TGCCATTTTTTCATTCATTAGAATTCAGTGCATTATGTTATTTTGTTATCTCTGCAGTAACTTTCTATCATGTTATTTAT
TTTCTTTGTCTTATTTAAAGCTTCTGAGATTATGGATTTTTGTTTCCTTCCCTGAAGTTAAGTGTTATCATTCCTATATA
GTACTAAGCTGTCTACAGAATAGTGGGAGTCTGCCCTCTTGAGTTGGGAAGATCCTAGTTTGAATCTTGGCTGTGCGACT
TTAAAGTTCATTAACTTCTCTTAGCCTCAGTCACCTGAACTCTGCAGTGGGGATCCTTATGCCTCAGAGTGTCATTGGGA
GGACTCACGAAAATACGCTTGTACTTTGAGTTCAGTACCTAGCCTGTATGAGCCAGCATTAAGAGGGACAGTCATCACGC
AGCGCTTTGCACACAGCTCTCACGCCACATCCTTTGGCTACTGTTTTGGTAAATCTTTACTAGTAAATGTTTCTTAAAAG
CATTTACATTCATGGACATGATTCAGAAACTAACAGTTGTTTTTTAGGTCTCACTTTGAGATTTAAAAACCCTTAGGGCA
GAGACCAGATTTTATTTCTTACCTCAGAGTTTCCCTGTAGGACAGGAACCAGCAACAGCCTAATGAGCTGATTAAGAATT
TTAGAGATTTAAAATTTAAATTAGGATTGCCAGTTTTAGAGACTGGCACATAAATGTTTTCATTTAAGGCAGTGACTGTT
TCCTTTAGGATATGATTTTTTATCTTTCTAAGATGAGATCACCATCCTCAGAATAATTTGTACCCCGCTGGGCACTAGCT
AATGGAGGTGATGTCATGCTAAGCAGCACTTCAGTGAGTTTTGCGGGAACCAAAGCTCTGCTCCCAGGAGTGTGGATTTG
GTGCTTTCATGTGGAAAAAGCGGATGATGACAAGTAGAGAGCAAATGTGCGCATGTCTGATGCTGTAAGGATTTCCTTTA
CCATCATATAAATTTTTAAAGTATATCAAAATAAACTGATAACTGAGAAAATATATGTTGTTCAGATACTAATAATGAAG
TTAATGAAGTCCACTATAGTATTTGTCCCTGAGAAATCTTTATCAAATATTTTAAATCCTATTGTAAAATAATGTATTTT
TTCTTTCAGTTTTAGAGACTGGCAATCCTAATTTAACATCTCCTTTTGAATTCCCCACCACAGGCACACTTTCACACATT
CACTCTTTAATAACAGGTTGTTTCAAATTGTTAATACTTTATAGCTTAATATAGAAATTTCACTTTAGAAATTAATTTTT
ATTTCTCTGCCTTAATGCTATAGATGTTGTAGTCTGCTTTACTTCAGTATTGTAATGAGTAGTTGGCTAACCACCATGTA
AATAGGGAGAACATTCTAGTTTTTTACTTGTGTAGGAAAACACAGCTTGAAATGTCTAAGTATCTATTTTAGAGTGAAGT
AAATTTATACTGACAATATTTTTTTGTGTTTGAAGACCTGACTGTTACAGCGTTGGTGGCAAGTGTTAAGGGATCCAGGA
ACTAGACAAGTGATTCTGAGACCTGAGTTCCAGGTTTCTAAGTAATATCAGTTGGTCTACTGAGAACTTTGCCATAAACA
TATGTGTTCAGAAATTTCCTTTCTTAGCAGCAGCATCCTGAATTGAACAGAATTACACACACATCAGCCCAGTAAGAAAC
AATTCATGTTAAGTCCATTGCTATGCCAGGATAAATCTTTTAAATCACAATTATTTTTCCTATTTATATTTTGTCAAATA
AGAATGTTCTAAAAACCAAAATTTCTGTTTTCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCGCCCA
GGCTGGAGTGCAGTGGCGCGATCTCGGCTCACGGCAAGCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCC
TGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTG
TTAGCCAGGATGGTCTTGATCTCCCGAACTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAAAT
TTCTGTTTTCATTTAAGGCAGTGACTATTTCCCTTAGGATGTGATTTTTTTATCCTTCTAAGATGAGATCACCATCCTCA
GAATAATTTGTACCCTGCTGGGCACTAGCTAATGGAGGTGATGTCATGCTAAGCAGCACTTCAGTGAGTTTTGCGGGAAC
CAAAGCTCTGCTCCCAGGAGTGTGGATTTGGTGCTTTCATGTGGAAAAAGCGGATGATGACAAGTAGAGAGCAAATGTGC
GCATGTCTGATGCTGTAAGGATTTCATCTACCATCATATAAATTTTTAGAAGTATATCAAAATAAACTGATAACTGAGGC
AATGTATGTTGTTCAGATACTAATAATGAAGTTAATGAAGTCCACTATAGTATTTGTATAGTATTTGTATATTACAGTAC
TCTGAAAAGCTGGTCACTATTTAAAGTTTCCATTACCAGTCACAAGGAGAGAATAATTTTATCCCACAATTTTATTGCTG
GCAAAAGACACAAGTTTATTAAAAGTCAGTATTTCAGTGTAAGAGTTACTAGACTGTTTGCAGAAGTGTTCAAAAGAGAT
CTTTAGGTCCTTGGTTGTCTGTGGAAGCTGATCAGCATTTAGGGGTTCCTGAGCACAGACTGTGAACCCTGCATTTGGCA
CATGCATTCAGAGAGCCAATTTGAGGCAGACTGGGGGCTAGAAAGGATACTGCCAGGAGCTCCAGGTTCAGCTTCCGAAG
TTATTAAGTCTTATTTCCCAGTTTTTAAATTAGACTTCATTTTTTAGAGCAGTTTTAGGTTCAAACCAAAATTGAGAAGA
ACGTACAGAGACATCCTGTATCCCACCTGCCCCCCAACACGTGCGTAGTCTCCCCCATTATCAACATCCTGCACCAGAGT
AGTACATTCTTACAAAGGAACCTACACTGACACGTCATCATCACCCAAACGCCATCGTTCACAATCAAGTTCACTCTTGG
TGCTGTTTATCCTATGGTTTTGGACAAATTTACAAGGACTTGTATCCACCATTATATTGTCACACTGAGTAGTTTCACTG
CCTTAAAAAGTCTCCGTGCGGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGA
TCACGAGGTTAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCTGG
CATGGTGGCATGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAAACCTAAAGGCGGAGGTTG
CAGTGAGCCGAGACCACGCCACTGCACTCCAGCCTGAGCAAGGAGCGAAATTCCATCTCAAAACAAAAAAAAAAAAAAAA
AAAAATTCTCTGTGCTGTCTCCCTCCCTCCTAGCCACTGGCAACCACTGATCTTTTTACTGTCTCCATAGTTTTGCCTTT
TCCAGATTGTCAGATAGTTGGAATCATGCGGTATATATGGCCTTTTCAAACTGGCTTCTTTCACTTAGTAATAATGCATT
TAAAGTGTTCATGGCTTGCTAGCTCATTTCTTTTTAGTGCTCAGTAATATTCTGTTCTCTGGATATACCACGGTTTATTT
ATTCATTCACCGACTGAAGGACATCTTAGTTGCTTCTAGTTTTGACAGTTATGAATAAAACTGCTATAAACATCTGTGTG
CAGGCTTTTGTGTGAACATAAGTTTTCAACTCCTTTGGGTAAATACCAAAGAGTGCGTATTTACCATATGGCTGGATCAT
ATGGTAAGAGTATGTTTAGTTTTGTAGGAAACTGCCAAACTGTCTTTCGAGTTGGCTGTACCATTTTGCATTTCCACGAG
CAGTGATTGAGAATCCCTGTTGCTCCACATCCTCACCAGCATTTGGTGTTGATGGTGTTCTGGTTTTGGCCATTCTGCTA
GGTATGTAATGATACCTCATTGTTGCTTTAATTAGCATTTCCCATTATTTGCAGTCTGTGTATCTTTGATGAGGCCCACT
GGATTTTCACTTTAGATTTTCTATAGATTGGCCATAAAGTCTTGAAACAAAGATATTTTCTCATGGATTATAATGCAATA
TCAGTAAACTATTATGTGTTCACCTACGTTTCCAGACTTGTTAGCTACCCTGTACTGTTCTCTCAGTTAATCAAGTTAAC
CACAATTTGTTTCTCAACCACAGGTGGCTAATGATTTTGTATGTGGTCTGTCCGCTTTGAATTGATGTGCATGGGGCAAG
TTGGTCTCTATGATATTCATGGTTCAAGGAAGTTCGAGATTTCCTGGTACCTAATACATGTTTATTGTACATATGAAAGA
AAAAAGGGCAGATAGAGGGGAACATGGTACTGAGCATGATAGAGGCAAGGAAGGGTGGCTACTTTGATAGGAGAATACCC
CTATTTTTGTCACTCTTGAAACAGGGCCAAGAGTTGAAATTGGCTAGAACAATCCTGACCTTTGTTGATATTATTTTATA
GAATAATATTTGTTACTGTTTTCTCACTTTTAAAAAATGCAGATGTTATAGAAAAATTAGAAGATATAGAGGAATGTTAA
GGAGTAAATAAGGTGTCAGTAATGCCATCACCCAGACAGCCACTGTTAATAAATATGTTAATATGTGAAGACATACTAAT
ATGTAATATGTACTGAGTGACTAATGGCAGGTCACTTAGTAGCTGTCTCGATTATCAGATCAACTGTCATGGTATGGCAG
TGTTTATGTTCAGGTACCCGTATTAGTTATTGTTGTTAATCCCTTTCTGCGCCCAAGTTATAAACTAAACTTTTTCATAG
GTATGTACGTATAGGAAAAAATATGCTGCATATAGGCTCAGTACTGTATTTGGTTTCAAGCATCTACTGGGGGACTTGGG
AGGTACCCCCTGCCCCTGCCCCACAGGTATACTACTGTATAATTATTCTTCTATCTAAAGTAAGATCTAATGGAAGATAG
GAACTTTGTCTTGTCTTCCACTCTGTCCTATTTCCCAGGATGATACCTGGCACAAAGTATTTGTTTACTGACAAACTAAA
AGATGATTTATCCCAATTATACTCACATCTTCCCTTGATTTTCCAGAAAGCCTACAGGAAGTAAGATGGTAGAAAAGCAA
AGTCTTCGTAGAAATGCAGAGCATAGACTGGCTCTTGGAGAAGGTCAAACATCACCCTCTCCTGTGGTTAAATTGAGATG
GTGGCACTGGCTGTCTTCTATATTATTGCTGCACCTTTCCTCACCAGGGGTGCACACAAAACTGGGAGAGAGGGGAGGAA
GGAGCTTAGCTTTGTCTTAATAGAAGGGAAGAAATGATGTTTTCCAAGAGACCTTGAAATTGGGGACCTTGGTAAAGGTT
TCAGTTTGGGAAGATAAAAAAGTCCTGGGATGGATTCCAACAGTGTAACTGTACTCAATGCCACTGAGCTGTACGCTTAA
GAGTGGTAAATTTTATGTCTATTTCACCACAGTTTTAAAGATTAAAATTTTTAAAAGTGGGGGAAGTTACCTAGGACTTT
CTAGAAGGACTTTTGAGGGTGAGCAAGTTCTGTTATAGGCTTGTGTATTATTTTGGTATTTCTGATTTTATCATAGGAGT
GAGGTTAAAGTTGTATTTTGACTGGAATTTTTGACATTGTCAGGGTTTCTAGAGTGTGGAGAAGGTCACTCAGTATTTTT
TGTTTTTGTTTTTTGTTTTGCCTTTGTTCTTGTTTTCCTCTATTTAGGGAGGTGGATTGCCATGGGAAGTACCTTTGCTT
CGAAAAGCCAGAAAATGCCTGGTAGAACTCCAGAAAAGTAGTAAGGAGCTGGCTTCTTCAGAGGCAGCATAGCAGAGTGG
GAAGAGGGCCCTGTCACTTAGATTGTGACTGTCGACAAAGTCACTTAACCACCAGAAGTTGGGTTTTCTGACGTTTAGAA
TTTTGAAAAGATTAAAACTGAGTGCCTTGCAAAGTACCTGGTATATATTAAGTGCTCAATAAGTGATAGTTGCTTTGATT
CTAAGAACTGGTTCACCTTGTGAGATATAATTGTGTAATGGAAGAATGAAAGCAGAAACTTTAGTTTCTACTTTTACATT
TCCTGGGCCATTTTACTACCCTAAATGAGAAGCTGGGCTTCCAAAACCCACTTTAAAAGTAAAGACTAGGCCGGGTGCGG
TGGCTCTTGCCTGTAATCCCAGCACTTTAGGAGGCCTAGGTGGGCAGATCACTTGAACTCAGGAGTTTGAGACCAGCCTG
GGCAATACAGCGAGACCGTATGTCTACAAAAAATACAAAAATTAGCCAGACATGGTGGTGCATGCCTGTAATCCCAGCTA
CTCGGGAGGCTGAGGCGGGAGAATTTGAGTCCAGGAGATCGAAGCTGCAGTGAGCCGTGATTGCGCCGCTGCCCTCCAGC
CTGGGTGACAGAGTGAGACCCTGCCTCAAAAGAAAAAAAAAAAAAGAATAAAGATTAATGGAGATTTGGAACATCTTGAT
ACTGTATCTTGGGAATCTAAGCATTGTAGAATTGTGTTATGTGAGTTATACCATTGTGGTGGGAAGTTTTTGATTTTTGT
TTTAACTGTGTTGAGTTGCAGTTCTTAGAAATGACCCGAGGTGTTGTCTTACAAAAGAAATAAACTGTAATCTGTATCTT
GATCTGATGAGGGTATGTAAATATAAAAAATCGAGCTGTATACTTTCTATATGCTTTATGTAGTTCACTATATATAATTC
ATAGCTCAATTAAAAAGAGAGAGAGAGGCTAAATTGTATGTACCATTGCAAAGAAATCATTATCCCCAGAACTGACTCAC
ATACACCTTTAACAGTAGAGGGAGAACTGAGGTATTAATTTGGAAAAATAATCACTGGGATAATTAATATAATGCAGTGG
TTTTATGACTGATTTTTTATTAACTTCTATTTTCTTTGTATTCTAGTTAATAAAGGTATCCATGGAGAACACTGAAAACT
CAGTGGATTCAAAATCCATTAAAAATTTGGAACCGTGAGTATTTAAATTGAATTCTTTATAATCAGAGAAAGATGGGGAT
GTGTAATAAGCAAACCTCGAGCAGTGGGGCAAGAGGAAAGAGAGTGGTCTCTCTCTCAGGCCAGAGAGACCAAGTGACTT
CCTACCTCAGACAGCTGTGTGGCTTTGCATAAACTGACTTTTCTTCTCTGAACCTCGTCTTTAACATGGGGCTAAAACTT
TCACAGAACTGAAGGGAAGATGAAAGGAAAGGCCTAGTAGGGTGTGTGACCCATAGTTGGAAACCTAGTCCTGGAACCAA
AAGGACACCACAGGAGAGGCAGGACTCCCAAGCGCCGGTGCTTTCTACCCTCCCGAATCGCTCTATAGGATTAGAGGGTT
TAGGTTTGGGAGGAGTTTCTTGACCTCTTGTTTATGAGTTTTTACGACTAAAATGCAATGCCAGTTTTCAGTCCGGGGAC
AAACTGCCTAGTTATGGATGAATTTTACCCTTTTTTTCCCCGTGTCTTTTTGGAATATTCTGCTTATTAATGCTTCCAAT
AACTAGCAGATGGAAAAAGGAAAAAGATAAAACTCAAATTCACTTTTTAATTCTTGTCTGTTATTATTTATTTGGGATCT
CTCGTAATACTTTAAATTCTGAAAGTTTATTTCTGAAACCCAGTATTGTTATTCTCGGCTGCCCTGAATATTACAAACTA
ATTTTATTACTAAACAATATGATTACAGAAATACTATTAACAAGTTACCACTAAAGATTTCACAATTTTGTTTAGCAAAG
GGATTTTTCTAGAAAGTAAACTTTTAAAATGCAGTCCCATTTTAGAGAGTTGTTGCTGTCATTTAAATCATTTTAGCCAG
TGCAGTGGCTTGCTCCTGTAATCCCAGCTACGTGGGAGCTGTGGCAGGAGGATCACTTGAGGTGGAGAGTTTGAAACCAG
CCTGGGCAACATAACGAGACCCTGTCTCTACAAAAAAACAAAAAACAATTAGTCCACCATAGTGTGTGTGCTTGTAGTCA
GTCCTAGCTACACGCCAGAGGTTACAGTGAAGTAAGACCCCATCTCTTCAAAAAAATCCTTTGAAAGTGATTTACACATT
TTCCTACTATTTTTTTTTTCTTTCTTTTTTGAGACAGGCTGGAGTGCAGTGATCTGATTATGGCTCACTGCACTCCTGGG
CTCCAGTAATCCTCCTGAGTAGCTAGGACTACAGACATGTGCCACCATGCCTGGTTATTTTTGTTTTTTATTTTTGTAGA
GATGGGGGTCTTGCTGTGTTGCCCAGGCTGGTCTCCAATGCCTGGCCTCAAGGGATCCTCCTGCCTCGGCCTCCCAAAGT
GCTGGGAGTACAGGTGTGAACCACCCTGCCTGGCCCTACCTTTTCATGTCATGCAGAACACCACTTCAATAACAAGTTGC
ACGGAAGCCCCAGACAGGTTTAGGGTTGTTTCGATCCTTTGGTAAGTTGCCCTCACAGTCCCGGCTTTCACAGCCTCTGC
CTTTTATTAGGAGTATCCCCTCGTGGACTAGCTATCATATGCTTGTAAAGTACCTACCTCCTTAGGAGGCACCCAGAGCA
CGTGGGGAAGGGGTGTCGGGAGCTGGGAGTCATAAGTCCCATGATCCATCATCTGTAGGACTCAAAGGTCAAGTCACGCT
TTCAGGATTTAACTTCAGTCTGTAAATGTGAGGCTGTTCACCTCTGGTTAAAAATCATAACTGTTTTCTCACGTTGACTC
CTTTAATTTACTACATTTAATCTTTTTCCAACAGTATTTTTGGAATTGTGTATAATGTGAGATGCTCTTAAGGTTAAGTG
CATGAGTATATGGACTGTAGGTGTTAGTGTTTGGTAGTTCCTAGACCTGTTTTTGCCTGACTCTTGGTCTAGATCAGGGA
TCAAGCTTAAGGCCTGTTTTTATCAACTTTCGTTGGAATATAGGCACATCCATTCGCTTACATATTGTCCTAAGCCCGTT
TCACCAGTATAATTGAGCAGCTATGGCTGGGCACAGTGGCTCACAACTGTAATCCCAGCACTTTTGGAGGCCAAGGCAGG
AGGATCACTTGAGGCCAGGAGTTCAAGACTAGCCTGGGCAACATAGCGAGATCCTGTCTCTAAAAAAGAAAATACAGAAA
TTAGCTGGGCATGGTGGGGCATGCCTGTCTGTAGTCCTAGCTACTCAGAAGGCTGAGGAAGGAGTATCACTGGAGCCCAA
GAGTTCAAAGTTGCAGTGAGCTATGATGGCACCACTGCACTCCAGCTTGGGTGACAGAGCCAGACCATGTCTCAAAAAAA
AAAAAAAAAGAATAGAATTGAGTAGCTGTAACAGAAACCAGATGGCCCACAAGCCTAAAACACTTAATATTTAGCCCATT
AAAAAAAAAGTTTACTGACCCCAATCTAGATAGCAGAGGTTTTTTTAGATAAGTGACTTCCAGACAGATATTTTCAATTA
TTTACAATAATGCTTTTATATATTAATAAATTACTAATTTGTTTAGCTCATGGGGTTTAAGGAATAATTTATGAATTGTG
ATAAATATTGTGCTTTGAGTTATATTTGCATTTTGTTGATTTCCCATCATTTCAGGGTAATTTTTAAGATTTTTACTCTT
ACCTCAAAGGATAAAATATTTCACAAAGTTAATAAGTAATTTTTAAATTATAAAGGTATTTGATGAAATTTTGAAGAATT
TAGAGGAAAATGTAAAACATGGAAGTTAAAAGCCTGAACTCTGAAGTCCAACAGATGCTTTCCTTCCTTCTTGGCTGTGA
CACAATATTTGCATAACCTTTAGCACATTACTTAGCCTCACGTCAGGTCATTTTCTCATCTGTATAACTGTTGATGTGAA
ATTGAAATGAAGACAGCCTGGTTTATAACATTCAACAAGTGTTAACTGTTACTGTGAGTTATAAAAATTGCACTAATATA
AACAGAAGGCGTGGTCATTTCTACCTTTGTAAAGCTATTATTTGATTTCTAAACAGAAAGATCATACATGGAAGCGAATC
AATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGAGATGGGTTTATGTATAATAATTAATAATA
AGAATTTTCATAAAAGCACTGGTATGTGTCTTACATAATTTTTAATCCTTTTCAAATGTTTGTGCCATTTACATTTGATA
TAATATTAAAAGCAGTATTATTGAGGTATTAGACAGTAAACCGTGACACAGACTAGCTGTGAAGTAGAGATTGGGCAGGA
CCTACAGGTCCTCTGATACACTGTGAACGCGTCACTCTTCTGCCCAACTTCATAGCCTCCTCTTGCTGGCCTCCTATCTG
TATGCTTGGTTGCCTCTGCCCTGACTTCTCTGTAGCCCTTGCTTCTTTTTCTTCTTTCTGCTTCCTCTTTGATCCCAATG
GAAGGTTCTCAAAAAAACAGTTAAGTGGTAGTATTTATTTTTTCCCCAGAAACTGCAAGAGATATCACAAGCATTGCCTT
ATTTAATTTATGACAACCTGGAAAGTAACGATGAGATTCTGAAAGGTTAAAGACCTCGCGCAGTCACACAGTATGGCGGC
AGAGCTAGGTCTGTGTGGCTCCAAAGCCCAAGCTCTGAATCCATCTTCTGTTCTGCTTCACTTCCTTGTATCCTCATGTG
CTCTGTTGCCTGTCTTCCCTTACCCTACGAAGCTCCCCATCTTAGAGAGACCTTTCTTTTACTCTGTTCCTTTTGATTCC
TTTGATATTTTGTCTCCTTCCCTTCTTCCTTAAATTTTGAATACATGTAGTTTAAGCTTGTACTCTTCATTTGTTTCCAT
TCCTTCTTGAGTCTTTTTCCATTTTCTGTCTCTACTACTAAAACTGCTTGCTTTAAATTTACCATGGCCTTGCCACCAGA
TCCCCCTCTCGATTTCTGTACTATGTACAACTTGAATGTAGTACTACATTTGAGAATGTTTTTTTAGAAATATAGATAAT
AAAATCCTTCACAGTGCCAAAAAAGCTAATTAATATTTGGTGTATTGTTATTTTTTCTTGGCAGTTCTTTTTAAAGCTTG
ATTTTATTCATAACGTATAAGCAATGTTGTCTTCTGCTTGTTTCACTTAAAGGAATAGCATTTTTCATATTGCTGCATAA
TTTTCATATCTGTTATAATGATTATATAATACTGCATCCCCAAAACTACCATTCACTTAATTTGAATAATTTACTGTATG
AATGAACATTATGGCTGTTTCCCTTTTAAATTGATGCTATGATAATTCTTTGAATTGGCCTATTAATCATATTAGAGTTA
ATTTTTAATTAGAGAAGCTGTAGTAGATCTAAGGTGGGCCAGTACCTATCAGAGTGGTGGTGGAAATGGAAGGAAGCCAG
ATTACACTGGGAAGATAGCAGGGTTTGTGTCAGATTAATTATAAGGAGTGAGAAGAGAATAGTTGAAAATGGAGCTCTAA
ATGGCATCAGTTTTATTGCTTTTGGCTATAAGTTGAGATGCCACCTTCAACCATTAACTTAAAAACACAACACCTTGTTT
ACTTTTGCTTTACGCATATTTGAAAATTTACTTCTAGATATTCTGCCTCACATTTCTAGTTAGGATACCTCCTTCCTATA
GAATTTTGCACTGTTGGCTCTATTGTTTCAAAAACCAAAAACAAGCATATTATTCCACTACCACCAGCACCTCCCCCCAC
ATATTTAGACCAGCAGTCTGGGTTTTGCCCAGTGAGCTCCTTTCCTACTTTGCAATGTAAAGGTCAGGTTCTCATGAGAT
CTCTGGCAGGCTGGTGTTGGGCCAGGCGCCATGGCTCACACATGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGAT
CCTTGAGCACCAAAGTTCAAGATCAGTCTGGGCAACACAGGGAAATCCCATCTCTACAAAACAGAAAAAAGGTAGCAGGG
TGTGGTGGTGCGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGTGGGAAGATAGCTTGAATCTGGGAGGTTGAGGCTG
CAGTGAGCTGTGGTTGCTGTACTCTAGCCTGGGCCACAGAGCAAGATCCTGTCTAAAAAATAAAAATAAATAAAAATTAA
AAGGCAGCCAACACATCAGCACCAGAAGCCAGTGACCTTGTCACACAGCTGAGATAATCAACAACATTTTGGAGATACAT
GTAGACTTTCTGTATTTAATCTTCATACCCATCAAATTTACTCAATTCTGAGGGATGTTTCCCACCAAGATTTAGCATTT
TGAAATCTGAGTGCATCATGCAGTCAATCTGTACGTTAATGTGGAAGGTTCTCTAAAGGAGTGGTAGAAAGCCCAGGAGC
CCTGGATACAGGCCCAGCATAGCTTTGTCACTTTGGACTGGTTTGTTAACTCTGCTACATGTCCCACATCTGCACAAGTG
AAACTAGTAATAATATGACTCTCATGGTGATTGGAAGGATTAGAGATTAGCCATAGCAGAATACCTGATGAACAGTAATA
ATGTTTGGGGGTTTTCCTTGAAGGCACTATAAATGTTGTAATGCTATCTTAAAATTGTTGGGAAGTTAGAGTCAGAGAAA
CGCATTTCCTCTGAGTGTGACAGATGTGTGTATGTATTATAGGATCGTATTGTTTTCTAGTCTTATTTTTTTAAACTGAT
GATTTTCCCATGGCAACATTTTATCTGTGAAAATGACAACATAGTATATCCCATTATATAAGTTAGTATAGCTTGTCTAA
CCAAACCCTTATTGTTAGACATTTGTGTTTTTCACTACCTAAACCGCTGTGAAAGACATCATTTTGGCTATAACACTGAT
GAGCTTATATTATGAAGTATCTTATAAGCTACAAAATTGAAGAAATTTTGTTCACCATGTTCAAAATAGTTAGAATTCTC
TTACCATTTAAAAGGAAGAATTTATTGTGGACTTCTGAATTGCTGAGTAGTTAATTTCATTTCAAAGTAGTTATTCTTTG
TTTTCCATACAATTAAAAGTAATTCTTTCTGTTCCAAGGAATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACC
TCAGGGAAACATTCAGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGGTAAGAAGAAACAATTAGAATGAACTTCATTGTACAATTAATTTTATACTATGGTCTAGCAATAATTATATGT
ATAATAAAATATGAGAATTGTGGAATTATACTGTACATAACCCTAATCTTACATACTTTAGTAAGAAGTTTAAAAAAAGT
TATTTATGCCAACTTCCTAAAATGGTTTGAGATGTGTTGCCGTGCCCCAGGTTAGGTTAAGATGACCTCTTAGTTTTAGT
CTCAGTTTCTTCATCATGTTCCCATACAGTATATCTGAAGTTGTTGAATAAAGTCATGGATTTTTTTTCCTTTTATTTGC
AAATGTCTTTACAGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAG
GAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTA
ACTGGAAAACCCAAACTTTTCATTATTCAGGTAATGTCTAACTGAGTGATTTGGTTATTGACGATTAAGCAGGGGTTACT
ATTCTCAACTGTAAATTATCCAAAGGATAATTTTTTTCCTGAAGCTAATGAACTATTGTTACTTTTCATTTATTTACCAC
TTAAAAGATATAGAGTAAATTTTAATTTTATACTTATATCAAAAAGACTCAGCATAATTAACATCCTTTTTTTTTTTTTT
TTTTTTTTTTTTAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGCGCGATCTCCGCTCACTGCAAGCTCTG
CCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCTGCCACCAGGCCCAGCTAA
TTTTTAAATTTTTTTTTAATAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCAAGTCATCC
GCCCGCCTTGGCCTCCCAAATTGCTGGGATTAAAGGCGTGAGCCACCGCGCCCGGCCAATTAACATCCATTTTTACATAG
CATTTCAATTTTTTAGAACTAAGTTATGTGTTCACACACAAATTTTTATAAATAAATATTTATTTTCTAACACCCAGGCC
TGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGATGACATGGCGTGTCATAAAATACCAGT
GGAGGCCGACTTCTTGTATGCATACTCCACAGCACCTGGTGAGAACGTTACACATAATGAATGTTACATGTGGATTTTAA
ATGAATTAACTGTGACTGATCATAGAATTATACAATGAAAAGTGTGTTTCAGAGACTGTCAAGATTTTGATATCCCTAAA
GATATCAAAACTTGTCTATATTTTAGGGAACCTTCATCAAAGAGAAGTCTCAAAAAGTTGTCTTTAGCCAAAAGTTTGGC
TAGAAAATATGCATATATAGCCAGGCACAGTGACTCACGCCTGTAATCCTAGCGCTTTGGGAGGCCGAGGCAGGTGGATC
ACTTGAGGTCAGGAGTTCAAAACCAGCCTGGCCAACCTCATCTCTACTAAAAATACAGAAAAATTAGCTGGGCATGGTGG
CACACGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGCAAAGGTTGCAGTGAGC
CAAGATCGCACCACTGCACTTCAGCCTGGGCGACAGAGTGAGACTCCGTCTCAAAGGAAAAAAAGAAAAGAAAATATGCA
TATGTAGAGTAGACTAGCACGATGTCATTCATTGGACTTTATCAGGTAGATCTCCGCTACTAATATCAGGTAGAATATTA
CGTGGCAACAGAGGCCAAGTCAGAGCTTCCCCTGCATCTTAGAGAAGAAGAGAGGTACGTTTCTCAGGAGTTATTTGAAA
GGTAGTAAATAAAAAAGATAAACATGACTAGTATACAAGAGGATAGATGTGGAGTGGGAGAAAAGAAGGTAAAAAACGAT
ACATGAATGTGCCGTTAACCTCCACGTTTTTACTGTTCTGCTGCACACGTCATCATCTAAATAAACATTTGTGGATTATA
CCACCATTTACTCACACAGCTAAGGGTGTCGGAGAGTTTGGAAACTTTAGGTAAATGTATTCTTAAGCAGTGTTGCATTT
TAAAATATGCTCAATATGGTTTATCTTATCCTCTAGGCATCTTTCCAAGCAAAGTACCTCTAAGTTAAAAGCAATGGGTC
TAATAGTTAACCTAGAAAAAAAAGTATGATAAATATACTATTTTCCCTTTTTGGACCAATACTTGGTAGTGTGTTTATTA
TACTTTATTCAGATGCTCTGTAGACAAGTAGGACACTCAAAGCAATTTGTTTCTTGGCTAAGTCAGTATTAAAATAAGGT
GAAATCTGATTGGAACACTGTGCTACTTACAATGATCCTTTTTATACATCTTTACTTTTGCATCTTACCTTCTGCGTGTT
TGCTCTTCTTGCCTATTGAAAGGGGAGTCCAGAAAGTAAAACTTTCAATAATTCAGTGTTCGTGAAGCTGGTCCCCGGCC
AGCTTTGCTGAAAGCAGGGGGTGTACGCATAGCACACATTCGTCCTTCAGCATCATTTCTTCTGAAACCAAAGGTGTCTT
TTTTTTTTTATTTGTATGACTAATAAGACTTATGTAAGTTTATGCTTATTTTTGCCTTTATGACTACATAATAATTTATA
GAATCAACTAAAATCAGCTATCCATGGTATTTTGCTTGTATTTTGCCTTTTAGGTTATTATTCTTGGCGAAATTCAAAGG
ATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACC
CGGGTTAACCGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCATG
TATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTTGGTTGGTGGTTTTTTTTAGTTTGTATG
CCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTACTCTCATGCTGCAGAGGGTACTTTAAG
ACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGTCAGGTAGTTGCAATTGAATTAAATTAG
GAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTCATGATTAGCAAGTT
ACAGTGATGCTGTGCTATGAATTTTCAAGTAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTTTTATGATATTCCCC
CCACTTAAGACTGTGTATTCTAGTTTTGTCAAACTGTAGAAATGATGATGTGGAAGAACTTAGGCATCTGTGGGCATGGT
CAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCATTTTTAGACCATTTATCTGGGATTATG
GTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAAAGAAACTAATATTT
TATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGGGTGGAGTTTTAACT
GTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTTCTGATTTGTCCCTATGCATATCAGTTGAGCTTCATA
TACCAGCAATATATCTGAAGAGCTATTATATAAAAACCCCAAACTGTTGATTATTAGCCAGGTAATGTGAATAAATTCTA
TAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAAAGCAATAAATGAATGGGCTGAGCTGCCTG
TAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAGCCATGGACCACGCA
GGAAGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCCAAGTAAGAAA
GTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAGTACTCTTTGTAGCA
AAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGTAATGTTTTATACTGTTTACTGAAAGAA
AAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGAGCTGAGCCCTCAGCCCGGGAGGCAGGCTC
CAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAGTATGACATTTCACGGGAGATTTCTTGT
TGCTCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAAATACACATAG
CATGTAATGGTATCTTAAAGTGTGTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTTTTATTTCAAAATAT
ACATTCAAACTTAAAATTAC
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Primary source |
RefSeq : NM_004346.3 (GI:73622121)
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Name |
Caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
2689 nt
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Map |
4q34
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Location |
Chromosome 4 (NC_000004.11) strand : -
185548849...185550654 | 185552190...185552310 | 185552918...185553093 | 185553421...185553549 |
185556447...185556571 | 185559554...185559621 | 185569618...185569784 | 185570548...185570628 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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81
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81
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1
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Exon 2
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82
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248
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167
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1
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Exon 3
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249
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316
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68
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1
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Exon 4
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317
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441
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125
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1
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Exon 5
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442
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570
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129
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1
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Exon 6
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571
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746
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176
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1
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Exon 7
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747
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867
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121
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1
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Exon 8
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868
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2673
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1806
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1
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ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
rs4647603
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SNP
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137
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a/g
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1
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?
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dbSNP
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Primary source |
NCBI : CCDS3836
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Nucleotide |
CASP3, mRNA isoform alpha[NM_004346.3] : 264...1097
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Length |
834
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Location |
Chromosome 4 (NC_000004.11) strand : -
185550425...185550654 | 185552190...185552310 | 185552918...185553093 | 185553421...185553549 |
185556447...185556571 | 185559554...185559606 |
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Start codon |
1
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Translation |
NP_004337.2 |
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1 |
ACATCTCCCG |
GCGGCGGGCC |
GCGGAAGCAG |
TGCAGACGCG |
GCTCCTAGCG |
GATGGGTGCT |
ATTGTGAGGC |
GGTTGTAGAA |
|
81 |
GAGTTTCGTG |
AGTGCTCGCA |
GCTCATACCT |
GTGGCTGTGT |
ATCCGTGGCC |
ACAGCTGGTT |
GGCGTCGCCT |
TGAAATCCCA |
|
161 |
GGCCGTGAGG |
AGTTAGCGAG |
CCCTGCTCAC |
ACTCGGCGCT |
CTGGTTTTCG |
GTGGGTGTGC |
CCTGCACCTG |
CCTCTTCCCC |
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241 |
CATTCTCATT |
AATAAAGGTA |
TCCATGGAGA |
ACACTGAAAA |
CTCAGTGGAT |
TCAAAATCCA |
TTAAAAATTT |
GGAACCAAAG |
|
321 |
ATCATACATG |
GAAGCGAATC |
AATGGACTCT |
GGAATATCCC |
TGGACAACAG |
TTATAAAATG |
GATTATCCTG |
AGATGGGTTT |
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401 |
ATGTATAATA |
ATTAATAATA |
AGAATTTTCA |
TAAAAGCACT |
GGAATGACAT |
CTCGGTCTGG |
TACAGATGTC |
GATGCAGCAA |
|
481 |
ACCTCAGGGA |
AACATTCAGA |
AACTTGAAAT |
ATGAAGTCAG |
GAATAAAAAT |
GATCTTACAC |
GTGAAGAAAT |
TGTGGAATTG |
|
561 |
ATGCGTGATG |
TTTCTAAAGA |
AGATCACAGC |
AAAAGGAGCA |
GTTTTGTTTG |
TGTGCTTCTG |
AGCCATGGTG |
AAGAAGGAAT |
|
641 |
AATTTTTGGA |
ACAAATGGAC |
CTGTTGACCT |
GAAAAAAATA |
ACAAACTTTT |
TCAGAGGGGA |
TCGTTGTAGA |
AGTCTAACTG |
|
721 |
GAAAACCCAA |
ACTTTTCATT |
ATTCAGGCCT |
GCCGTGGTAC |
AGAACTGGAC |
TGTGGCATTG |
AGACAGACAG |
TGGTGTTGAT |
|
801 |
GATGACATGG |
CGTGTCATAA |
AATACCAGTG |
GAGGCCGACT |
TCTTGTATGC |
ATACTCCACA |
GCACCTGGTT |
ATTATTCTTG |
|
881 |
GCGAAATTCA |
AAGGATGGCT |
CCTGGTTCAT |
CCAGTCGCTT |
TGTGCCATGC |
TGAAACAGTA |
TGCCGACAAG |
CTTGAATTTA |
|
961 |
TGCACATTCT |
TACCCGGGTT |
AACCGAAAGG |
TGGCAACAGA |
ATTTGAGTCC |
TTTTCCTTTG |
ACGCTACTTT |
TCATGCAAAG |
|
1041 |
AAACAGATTC |
CATGTATTGT |
TTCCATGCTC |
ACAAAAGAAC |
TCTATTTTTA |
TCACTAAAGA |
AATGGTTGGT |
TGGTGGTTTT |
|
1121 |
TTTTAGTTTG |
TATGCCAAGT |
GAGAAGATGG |
TATATTTGGT |
ACTGTATTTC |
CCTCTCATTT |
TGACCTACTC |
TCATGCTGCA |
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1201 |
GAGGGTACTT |
TAAGACATAC |
TCCTTCCATC |
AAATAGAACC |
ACTATGAAGC |
TACCTCAAAC |
TTCCAGTCAG |
GTAGTTGCAA |
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1281 |
TTGAATTAAA |
TTAGGAATAA |
ATAAAAATGG |
ATACTGGTGC |
AGTCATTATG |
AGAGGCAATG |
ATTGTTAATT |
TACAGCTTTC |
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1361 |
ATGATTAGCA |
AGTTACAGTG |
ATGCTGTGCT |
ATGAATTTTC |
AAGTAATTGT |
GAAAAAGTTA |
AACATTGAAG |
TAATGAATTT |
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1441 |
TTATGATATT |
CCCCCCACTT |
AAGACTGTGT |
ATTCTAGTTT |
TGTCAAACTG |
TAGAAATGAT |
GATGTGGAAG |
AACTTAGGCA |
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1521 |
TCTGTGGGCA |
TGGTCAAAGG |
CTCAAACCTT |
TATTTTAGAA |
TTGATATACA |
CGGATGACTT |
AACTGCATTT |
TTAGACCATT |
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1601 |
TATCTGGGAT |
TATGGTTTTG |
TGATGTTTGT |
CCTGAACACT |
TTTGTTGTAA |
AAAAATAATA |
ATAATGTTTA |
ATATTGAGAA |
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1681 |
AGAAACTAAT |
ATTTTATGTG |
AGAGAAAGTG |
TGAGCAAACT |
AACTTGACTT |
TTAAGGCTAA |
AACTTAACAT |
TCATAGAGGG |
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1761 |
GTGGAGTTTT |
AACTGTAAGG |
TGCTACAATG |
CCCCTGGATC |
TACCAGCATA |
AATATCTTCT |
GATTTGTCCC |
TATGCATATC |
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1841 |
AGTTGAGCTT |
CATATACCAG |
CAATATATCT |
GAAGAGCTAT |
TATATAAAAA |
CCCCAAACTG |
TTGATTATTA |
GCCAGGTAAT |
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1921 |
GTGAATAAAT |
TCTATAGGAA |
CATATGAAAA |
TACAACTTAA |
ATAATAAACA |
GTGGAATATA |
AGGAAAGCAA |
TAAATGAATG |
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2001 |
GGCTGAGCTG |
CCTGTAACTT |
GAGAGTAGAT |
GGTTTGAGCC |
TGAGCAGAGA |
CATGACTCAG |
CCTGTTCCAT |
GAAGGCAGAG |
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2081 |
CCATGGACCA |
CGCAGGAAGG |
GCCTACAGCC |
CATTTCTCCA |
TACGCACTGG |
TATGTGTGGA |
TGATGCTGCC |
AGGGCGCCAT |
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2161 |
CGCCAAGTAA |
GAAAGTGAAG |
CAAATCAGAA |
ACTTGTGAAG |
TGGAAATGTT |
CTAAAGGTGG |
TGAGGCAATA |
AAAATCATAG |
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2241 |
TACTCTTTGT |
AGCAAAATTC |
TTAAGTATGT |
TATTTTCTGT |
TGAAGTTTAC |
AATCAAAGGA |
AAATAGTAAT |
GTTTTATACT |
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2321 |
GTTTACTGAA |
AGAAAAAGAC |
CTATGAGCAC |
ATAGGACTCT |
AGACGGCATC |
CAGCCGGAGG |
CCAGAGCTGA |
GCCCTCAGCC |
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2401 |
CGGGAGGCAG |
GCTCCAGGCC |
TCAGCAGGTG |
CGGAGCCGTC |
ACTGCACCAA |
GTCTCACTGG |
CTGTCAGTAT |
GACATTTCAC |
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2481 |
GGGAGATTTC |
TTGTTGCTCA |
AAAAATGAGC |
TCGCATTTGT |
CAATGACAGT |
TTCTTTTTTC |
TTACTAGACC |
TGTAACTTTT |
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2561 |
GTAAATACAC |
ATAGCATGTA |
ATGGTATCTT |
AAAGTGTGTT |
TCTATGTGAC |
AATTTTGTAC |
AAATTTGTTA |
TTTTCCATTT |
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2641 |
TTATTTCAAA |
ATATACATTC |
AAACTTAAAA |
TTAAAAAAAA |
AAAAAAAAA |
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>gi|73622121|ref|NM_004346.3|Caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha
ACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAA
GAGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGTGTATCCGTGGCCACAGCTGGTTGGCGTCGCCTTGAAATCCCA
GGCCGTGAGGAGTTAGCGAGCCCTGCTCACACTCGGCGCTCTGGTTTTCGGTGGGTGTGCCCTGCACCTGCCTCTTCCCC
CATTCTCATTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAG
ATCATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGAGATGGGTTT
ATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAA
ACCTCAGGGAAACATTCAGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTG
ATGCGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAAT
AATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTG
GAAAACCCAAACTTTTCATTATTCAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGAT
GATGACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCACCTGGTTATTATTCTTG
GCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTA
TGCACATTCTTACCCGGGTTAACCGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAG
AAACAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTTGGTTGGTGGTTTT
TTTTAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTACTCTCATGCTGCA
GAGGGTACTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGTCAGGTAGTTGCAA
TTGAATTAAATTAGGAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTC
ATGATTAGCAAGTTACAGTGATGCTGTGCTATGAATTTTCAAGTAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTT
TTATGATATTCCCCCCACTTAAGACTGTGTATTCTAGTTTTGTCAAACTGTAGAAATGATGATGTGGAAGAACTTAGGCA
TCTGTGGGCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCATTTTTAGACCATT
TATCTGGGATTATGGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAA
AGAAACTAATATTTTATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGG
GTGGAGTTTTAACTGTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTTCTGATTTGTCCCTATGCATATC
AGTTGAGCTTCATATACCAGCAATATATCTGAAGAGCTATTATATAAAAACCCCAAACTGTTGATTATTAGCCAGGTAAT
GTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAAAGCAATAAATGAATG
GGCTGAGCTGCCTGTAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAG
CCATGGACCACGCAGGAAGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCAT
CGCCAAGTAAGAAAGTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAG
TACTCTTTGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGTAATGTTTTATACT
GTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGAGCTGAGCCCTCAGCC
CGGGAGGCAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAGTATGACATTTCAC
GGGAGATTTCTTGTTGCTCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTT
GTAAATACACATAGCATGTAATGGTATCTTAAAGTGTGTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTT
TTATTTCAAAATATACATTCAAACTTAAAATTAAAAAAAAAAAAAAAAA
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Primary source |
RefSeq : NM_032991.2 (GI:73622122)
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Name |
Caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant beta
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Type of transcript |
mRNA
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Organism |
Homo sapiens
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Length |
2522 nt
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Map |
4q34
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Location |
Chromosome 4 (NC_000004.11) strand : -
185548849...185550654 | 185552190...185552310 | 185552918...185553093 | 185553421...185553549 |
185556447...185556571 | 185559554...185559621 | 185570548...185570628 |
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Exon(s) |
Start |
End |
Length |
is coding |
Exon 1
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1
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81
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81
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1
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Exon 3
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82
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149
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68
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1
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Exon 4
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150
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274
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125
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1
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Exon 5
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275
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403
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129
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1
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Exon 6
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404
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579
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176
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1
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Exon 7
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580
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700
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121
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1
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Exon 8
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701
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2506
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1806
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1
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Primary source |
NCBI : CCDS3836
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Nucleotide |
CASP3, mRNA isoform beta[NM_032991.2] : 97...930
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Length |
834
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Location |
Chromosome 4 (NC_000004.11) strand : -
185550425...185550654 | 185552190...185552310 | 185552918...185553093 | 185553421...185553549 |
185556447...185556571 | 185559554...185559606 |
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Start codon |
1
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Translation |
NP_116786.1 |
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1 |
ACATCTCCCG |
GCGGCGGGCC |
GCGGAAGCAG |
TGCAGACGCG |
GCTCCTAGCG |
GATGGGTGCT |
ATTGTGAGGC |
GGTTGTAGAA |
|
81 |
GTTAATAAAG |
GTATCCATGG |
AGAACACTGA |
AAACTCAGTG |
GATTCAAAAT |
CCATTAAAAA |
TTTGGAACCA |
AAGATCATAC |
|
161 |
ATGGAAGCGA |
ATCAATGGAC |
TCTGGAATAT |
CCCTGGACAA |
CAGTTATAAA |
ATGGATTATC |
CTGAGATGGG |
TTTATGTATA |
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241 |
ATAATTAATA |
ATAAGAATTT |
TCATAAAAGC |
ACTGGAATGA |
CATCTCGGTC |
TGGTACAGAT |
GTCGATGCAG |
CAAACCTCAG |
|
321 |
GGAAACATTC |
AGAAACTTGA |
AATATGAAGT |
CAGGAATAAA |
AATGATCTTA |
CACGTGAAGA |
AATTGTGGAA |
TTGATGCGTG |
|
401 |
ATGTTTCTAA |
AGAAGATCAC |
AGCAAAAGGA |
GCAGTTTTGT |
TTGTGTGCTT |
CTGAGCCATG |
GTGAAGAAGG |
AATAATTTTT |
|
481 |
GGAACAAATG |
GACCTGTTGA |
CCTGAAAAAA |
ATAACAAACT |
TTTTCAGAGG |
GGATCGTTGT |
AGAAGTCTAA |
CTGGAAAACC |
|
561 |
CAAACTTTTC |
ATTATTCAGG |
CCTGCCGTGG |
TACAGAACTG |
GACTGTGGCA |
TTGAGACAGA |
CAGTGGTGTT |
GATGATGACA |
|
641 |
TGGCGTGTCA |
TAAAATACCA |
GTGGAGGCCG |
ACTTCTTGTA |
TGCATACTCC |
ACAGCACCTG |
GTTATTATTC |
TTGGCGAAAT |
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721 |
TCAAAGGATG |
GCTCCTGGTT |
CATCCAGTCG |
CTTTGTGCCA |
TGCTGAAACA |
GTATGCCGAC |
AAGCTTGAAT |
TTATGCACAT |
|
801 |
TCTTACCCGG |
GTTAACCGAA |
AGGTGGCAAC |
AGAATTTGAG |
TCCTTTTCCT |
TTGACGCTAC |
TTTTCATGCA |
AAGAAACAGA |
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881 |
TTCCATGTAT |
TGTTTCCATG |
CTCACAAAAG |
AACTCTATTT |
TTATCACTAA |
AGAAATGGTT |
GGTTGGTGGT |
TTTTTTTAGT |
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961 |
TTGTATGCCA |
AGTGAGAAGA |
TGGTATATTT |
GGTACTGTAT |
TTCCCTCTCA |
TTTTGACCTA |
CTCTCATGCT |
GCAGAGGGTA |
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1041 |
CTTTAAGACA |
TACTCCTTCC |
ATCAAATAGA |
ACCACTATGA |
AGCTACCTCA |
AACTTCCAGT |
CAGGTAGTTG |
CAATTGAATT |
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1121 |
AAATTAGGAA |
TAAATAAAAA |
TGGATACTGG |
TGCAGTCATT |
ATGAGAGGCA |
ATGATTGTTA |
ATTTACAGCT |
TTCATGATTA |
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1201 |
GCAAGTTACA |
GTGATGCTGT |
GCTATGAATT |
TTCAAGTAAT |
TGTGAAAAAG |
TTAAACATTG |
AAGTAATGAA |
TTTTTATGAT |
|
1281 |
ATTCCCCCCA |
CTTAAGACTG |
TGTATTCTAG |
TTTTGTCAAA |
CTGTAGAAAT |
GATGATGTGG |
AAGAACTTAG |
GCATCTGTGG |
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1361 |
GCATGGTCAA |
AGGCTCAAAC |
CTTTATTTTA |
GAATTGATAT |
ACACGGATGA |
CTTAACTGCA |
TTTTTAGACC |
ATTTATCTGG |
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1441 |
GATTATGGTT |
TTGTGATGTT |
TGTCCTGAAC |
ACTTTTGTTG |
TAAAAAAATA |
ATAATAATGT |
TTAATATTGA |
GAAAGAAACT |
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1521 |
AATATTTTAT |
GTGAGAGAAA |
GTGTGAGCAA |
ACTAACTTGA |
CTTTTAAGGC |
TAAAACTTAA |
CATTCATAGA |
GGGGTGGAGT |
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1601 |
TTTAACTGTA |
AGGTGCTACA |
ATGCCCCTGG |
ATCTACCAGC |
ATAAATATCT |
TCTGATTTGT |
CCCTATGCAT |
ATCAGTTGAG |
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1681 |
CTTCATATAC |
CAGCAATATA |
TCTGAAGAGC |
TATTATATAA |
AAACCCCAAA |
CTGTTGATTA |
TTAGCCAGGT |
AATGTGAATA |
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1761 |
AATTCTATAG |
GAACATATGA |
AAATACAACT |
TAAATAATAA |
ACAGTGGAAT |
ATAAGGAAAG |
CAATAAATGA |
ATGGGCTGAG |
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1841 |
CTGCCTGTAA |
CTTGAGAGTA |
GATGGTTTGA |
GCCTGAGCAG |
AGACATGACT |
CAGCCTGTTC |
CATGAAGGCA |
GAGCCATGGA |
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1921 |
CCACGCAGGA |
AGGGCCTACA |
GCCCATTTCT |
CCATACGCAC |
TGGTATGTGT |
GGATGATGCT |
GCCAGGGCGC |
CATCGCCAAG |
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2001 |
TAAGAAAGTG |
AAGCAAATCA |
GAAACTTGTG |
AAGTGGAAAT |
GTTCTAAAGG |
TGGTGAGGCA |
ATAAAAATCA |
TAGTACTCTT |
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2081 |
TGTAGCAAAA |
TTCTTAAGTA |
TGTTATTTTC |
TGTTGAAGTT |
TACAATCAAA |
GGAAAATAGT |
AATGTTTTAT |
ACTGTTTACT |
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2161 |
GAAAGAAAAA |
GACCTATGAG |
CACATAGGAC |
TCTAGACGGC |
ATCCAGCCGG |
AGGCCAGAGC |
TGAGCCCTCA |
GCCCGGGAGG |
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2241 |
CAGGCTCCAG |
GCCTCAGCAG |
GTGCGGAGCC |
GTCACTGCAC |
CAAGTCTCAC |
TGGCTGTCAG |
TATGACATTT |
CACGGGAGAT |
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2321 |
TTCTTGTTGC |
TCAAAAAATG |
AGCTCGCATT |
TGTCAATGAC |
AGTTTCTTTT |
TTCTTACTAG |
ACCTGTAACT |
TTTGTAAATA |
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2401 |
CACATAGCAT |
GTAATGGTAT |
CTTAAAGTGT |
GTTTCTATGT |
GACAATTTTG |
TACAAATTTG |
TTATTTTCCA |
TTTTTATTTC |
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2481 |
AAAATATACA |
TTCAAACTTA |
AAATTAAAAA |
AAAAAAAAAA |
AA |
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>gi|73622122|ref|NM_032991.2|Caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant beta
ACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAA
GTTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATCATAC
ATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGAGATGGGTTTATGTATA
ATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAG
GGAAACATTCAGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGCGTG
ATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAATAATTTTT
GGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACC
CAAACTTTTCATTATTCAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGATGACA
TGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCACCTGGTTATTATTCTTGGCGAAAT
TCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACAT
TCTTACCCGGGTTAACCGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGA
TTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTTGGTTGGTGGTTTTTTTTAGT
TTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTACTCTCATGCTGCAGAGGGTA
CTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGTCAGGTAGTTGCAATTGAATT
AAATTAGGAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTCATGATTA
GCAAGTTACAGTGATGCTGTGCTATGAATTTTCAAGTAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTTTTATGAT
ATTCCCCCCACTTAAGACTGTGTATTCTAGTTTTGTCAAACTGTAGAAATGATGATGTGGAAGAACTTAGGCATCTGTGG
GCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCATTTTTAGACCATTTATCTGG
GATTATGGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAAAGAAACT
AATATTTTATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGGGTGGAGT
TTTAACTGTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTTCTGATTTGTCCCTATGCATATCAGTTGAG
CTTCATATACCAGCAATATATCTGAAGAGCTATTATATAAAAACCCCAAACTGTTGATTATTAGCCAGGTAATGTGAATA
AATTCTATAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAAAGCAATAAATGAATGGGCTGAG
CTGCCTGTAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAGCCATGGA
CCACGCAGGAAGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCCAAG
TAAGAAAGTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAGTACTCTT
TGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGTAATGTTTTATACTGTTTACT
GAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGAGCTGAGCCCTCAGCCCGGGAGG
CAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAGTATGACATTTCACGGGAGAT
TTCTTGTTGCTCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAAATA
CACATAGCATGTAATGGTATCTTAAAGTGTGTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTTTTATTTC
AAAATATACATTCAAACTTAAAATTAAAAAAAAAAAAAAAAA
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Exon number |
2
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Length |
167 nt
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Location |
Chromosome 4 (NC_000004.11) : 185569618...185569784 (-)
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Is part of |
CASP3, mRNA isoform alpha
(NM_004346.3)
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Sequence |
Show
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AGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGTGTATCCGTGGCCACAGCTGGTTGGCGTCGCCTTGAAATCCCAG
GCCGTGAGGAGTTAGCGAGCCCTGCTCACACTCGGCGCTCTGGTTTTCGGTGGGTGTGCCCTGCACCTGCCTCTTCCCCC
ATTCTCA
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Exon number |
8
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Length |
1806 nt
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Location |
Chromosome 4 (NC_000004.11) : 185548849...185550654 (-)
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Is part of |
CASP3, mRNA isoform beta
(NM_032991.2)
CASP3, mRNA isoform alpha
(NM_004346.3)
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Sequence |
Show
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GTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGAC
AAGCTTGAATTTATGCACATTCTTACCCGGGTTAACCGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTAC
TTTTCATGCAAAGAAACAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTT
GGTTGGTGGTTTTTTTTAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTA
CTCTCATGCTGCAGAGGGTACTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGT
CAGGTAGTTGCAATTGAATTAAATTAGGAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTA
ATTTACAGCTTTCATGATTAGCAAGTTACAGTGATGCTGTGCTATGAATTTTCAAGTAATTGTGAAAAAGTTAAACATTG
AAGTAATGAATTTTTATGATATTCCCCCCACTTAAGACTGTGTATTCTAGTTTTGTCAAACTGTAGAAATGATGATGTGG
AAGAACTTAGGCATCTGTGGGCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCA
TTTTTAGACCATTTATCTGGGATTATGGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGT
TTAATATTGAGAAAGAAACTAATATTTTATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAA
CATTCATAGAGGGGTGGAGTTTTAACTGTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTTCTGATTTGT
CCCTATGCATATCAGTTGAGCTTCATATACCAGCAATATATCTGAAGAGCTATTATATAAAAACCCCAAACTGTTGATTA
TTAGCCAGGTAATGTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAAAG
CAATAAATGAATGGGCTGAGCTGCCTGTAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTC
CATGAAGGCAGAGCCATGGACCACGCAGGAAGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCT
GCCAGGGCGCCATCGCCAAGTAAGAAAGTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCA
ATAAAAATCATAGTACTCTTTGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGT
AATGTTTTATACTGTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGAGC
TGAGCCCTCAGCCCGGGAGGCAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAG
TATGACATTTCACGGGAGATTTCTTGTTGCTCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAG
ACCTGTAACTTTTGTAAATACACATAGCATGTAATGGTATCTTAAAGTGTGTTTCTATGTGACAATTTTGTACAAATTTG
TTATTTTCCATTTTTATTTCAAAATATACATTCAAACTTAAAATTA
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Primary source |
Uniprot : P42574
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Name |
Caspase-3
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Alternative name(s) |
Apopain Cysteine protease CPP32 Protein Yama SREBP cleavage activity 1
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Synonym(s) |
CASP-3 CPP-32 SCA-1
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Organism |
Homo sapiens
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Length |
277 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Catalytic activity
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Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp- Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.
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Enzyme regulation
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Inhibited by isatin sulfonamides.
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Function
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Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
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Ptm
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Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
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Similarity
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Belongs to the peptidase C14A family.
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Subcellular location
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Cytoplasm.
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Subunit
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Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.
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Tissue specificity
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Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
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Biological process
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proteolysis [GO:0006508]
nuclear fragmentation involved in apoptotic nuclear change [GO:0030264]
response to tumor necrosis factor [GO:0034612]
negative regulation of apoptosis [GO:0043066]
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Cellular component
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nucleoplasm [GO:0005654]
mitochondrion [GO:0005739]
cytosol [GO:0005829]
plasma membrane [GO:0005886]
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Molecular function
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cysteine-type endopeptidase activity [GO:0004197]
protein binding [GO:0005515]
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Alternative product(s)
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Feature key |
Position
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Length
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Description
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Feature identifier
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Molecule processing |
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Propeptide
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1 - 9
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9
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PRO_0000004569
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Propeptide
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10 - 28
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19
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PRO_0000004570
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Sites |
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Active site
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121 - 121
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1
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By similarity
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P42574-ACT_SITE-121
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Active site
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163 - 163
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1
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By similarity
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P42574-ACT_SITE-163
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Natural variations |
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Natural variant site
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22 - 22
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1
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H -> R (in dbSNP:rs35578277)
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VAR_048616
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Natural variant site
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190 - 190
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1
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E -> D (in dbSNP:rs1049210)
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VAR_001401
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Amino acid modifications |
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Modified residue
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1 - 1
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1
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N-acetylmethionine
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P42574-MOD_RES-1
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Modified residue
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26 - 26
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1
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Phosphoserine (By similarity)
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P42574-MOD_RES-26
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Modified residue
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82 - 82
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1
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N6-acetyllysine
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P42574-MOD_RES-82
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Modified residue
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163 - 163
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1
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S-nitrosocysteine; in inhibited form
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P42574-MOD_RES-163
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MENTENSVDS |
KSIKNLEPKI |
IHGSESMDSG |
ISLDNSYKMD |
YPEMGLCIII |
NNKNFHKSTG |
MTSRSGTDVD |
AANLRETFRN |
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81 |
LKYEVRNKND |
LTREEIVELM |
RDVSKEDHSK |
RSSFVCVLLS |
HGEEGIIFGT |
NGPVDLKKIT |
NFFRGDRCRS |
LTGKPKLFII |
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161 |
QACRGTELDC |
GIETDSGVDD |
DMACHKIPVE |
ADFLYAYSTA |
PGYYSWRNSK |
DGSWFIQSLC |
AMLKQYADKL |
EFMHILTRVN |
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241 |
RKVATEFESF |
SFDATFHAKK |
QIPCIVSMLT |
KELYFYH |
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>sp|P42574|CASP3_human Caspase-3
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRN
LKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFII
QACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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Primary source |
Uniprot : D3DP53
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Name |
Caspase 3, apoptosis-related cysteine peptidase, isoform CRA_a [submitted name]
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Alternative name(s) |
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Synonym(s) |
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Organism |
Homo sapiens
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Length |
277 aa
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Protein existence |
---
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General annotation (Comments)
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top
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Similarity
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Belongs to the peptidase C14A family.
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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Feature key |
Position
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Length
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Description
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Feature identifier
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1 |
MENTENSVDS |
KSIKNLEPKI |
IHGSESMDSG |
ISLDNSYKMD |
YPEMGLCIII |
NNKNFHKSTG |
MTSRSGTDVD |
AANLRETFRN |
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81 |
LKYEVRNKND |
LTREEIVELM |
RDVSKEDHSK |
RSSFVCVLLS |
HGEEGIIFGT |
NGPVDLKKIT |
NFFRGDRCRS |
LTGKPKLFII |
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161 |
QACRGTELDC |
GIETDSGVDD |
DMACHKIPVE |
ADFLYAYSTA |
PGYYSWRNSK |
DGSWFIQSLC |
AMLKQYADKL |
EFMHILTRVN |
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241 |
RKVATEFESF |
SFDATFHAKK |
QIPCIVSMLT |
KELYFYH |
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>sp|D3DP53|D3DP53_human Caspase 3, apoptosis-related cysteine peptidase, isoform CRA_a [submitted name]
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRN
LKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFII
QACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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