(FADD) Fas (TNFRSF6)-associated via death domain [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  6511
 Official symbol  FADD
 Official name  Fas (TNFRSF6)-associated via death domain
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 11 (NC_000011.9) :  70049268...70053507  (+)
 Map  11q13.3
 Length  4240  nt
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Alternative name(s) and Synynom(s) top
Synonyms MGC8528; MORT1; GIG3
Alternative name(s) fas (TNFRSF6)-associated via death domain; mediator of receptor-induced toxicity; growth-inhibiting gene 3 protein; Fas-associating protein with death domain; Fas-associating death domain-containing protein
External Links top
Ensembl ENSG00000168040
Entrez 8772
HGNC 3573
HPRD 03909
Comment top
Summary The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq].
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Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
1  AGACGATACG CCGGGCGCAG GCGCAGAAGC CGCGCCCGTC CGCGGCGCCG CCAGCCAGGG CGGAAACGGC TGCGGCTTCG
81  CTAGGGACGC ATGCGCGGGT CCCTTAGTTT TCGCGAGATA ACGGTCGAAA ACGCGCTCTT GTCGATTTCC TGTAGTGAAT
161  CAGGCACCGG AGTGCAGGTT CGGGGGTGGA ATCCTTGGGC CGCTGGGCAA GCGGCGAGAC CTGGCCAGGG CCAGCGAGCC
241  GAGGACAGAG GGCGCACGGA GGGCCGGGCC GCAGCCCCGG CCGCTTGCAG ACCCCGCCAT GGACCCGTTC CTGGTGCTGC
321  TGCACTCGGT GTCGTCCAGC CTGTCGAGCA GCGAGCTGAC CGAGCTCAAG TTCCTATGCC TCGGGCGCGT GGGCAAGCGC
401  AAGCTGGAGC GCGTGCAGAG CGGCCTAGAC CTCTTCTCCA TGCTGCTGGA GCAGAACGAC CTGGAGCCCG GGCACACCGA
481  GCTCCTGCGC GAGCTGCTCG CCTCCCTGCG GCGCCACGAC CTGCTGCGGC GCGTCGACGA CTTCGAGGCG GGGGCGGCGG
561  CCGGGGCCGC GCCTGGGGAA GAAGGTGGGC GCGGGGCCGG GCCGGGGGAG CCAGGGCCTG GTCGCCCGGC TGTAGGTGCT
641  GCGAGGCTCC TCCGGTTGGC CTCCAGGCGC CTCCCCTTTG CCGGGTTTGA TTTGCGTGGG TTTTCTCCGT ACAGCCCTGG
721  TTTTGCAGAT GGGAGAGCCA GAAACGCAGA AAAGTTAACT TATTCGAGGT TGCAGGGCGT GGACACGCAC AGTCCTTTTT
801  CCTCCACCCA CTTCTGCCCG GGTAAATTAG AAAACTCACT GAAGAAAAGA TGAGTCAGAG AAGGTGTGGG GGAGGGGCAG
881  AGGTTGGGTG AGCCTGCCTC GCATCATTTC CTTTCTGTCT CGGAATATGC TTTTCACGGC TGTCTGAGAG TAATACTAGC
961  ATTCAGTAAC TCCTACCCAG GGGCTTACAG TGTGCCGCTT ACCCTTGTAA CTGCCAAATA CAATTTTCGC AGTAGCCCTG
1041  TGGCTTAGAT ACTGTTAGCT ATCACTGTTC CCATTTTACA GAGGACAGGA CTGTGGCTCA CAGGTTAAGT GGCTTTGTCG
1121  AAATGCGCAG CCGATAACTG ACGGAGCTAG GCTTGAGCCA AGCAGTCCGG CCTCCGGATG GGTAGTGTTA GCCACTACAC
1201  TGCCTCTCTG GTCAAGTTCA TTGTGGAGTG GCTTCCTGTC CTGCTCTCGG TCACTCCCTC TCCACCCTCG CCTGTGGATT
1281  GCAGCAGCTT CCAGGATAAA AAAGAAACCC TGAGTACAGC AGAGTTTCTC AGCCCTACCC CCCTTGTTCT CAGAGTCGGG
1361  AGAGGCTTGG GAGTGCTCTG GGGACGCCTC TCAGAGGCTT CAAGCTGTAG CTTGGAATCA GCCATTCAGT CACCAATCAG
1441  ATAGGGCCTA AATGTGTCAC CATGGGTTTC ACTCTGTAAA GACTGGTGCC TGTTGGGGAC AGGATGGACA GAACAGCTCT
1521  CTGCCTGAGA GCAGTCAAGT CCAGATTTTA AAAAAAATCA GTACTGAACA AACAAAACAG GACGTAGAAA AATCGGGTTT
1601  TATGGATATT TAATGTCTGG AAAAACACTG ATAAATTGCA TTTTAAAGGC GGTCTACGAA ACATAGCTGA CATTTGAGAT
1681  GTATGTGTGC TTGGTTTTAT TTATATCGTC ATGTAGTTAC TGTGTGCTGG GAAAAGTACA CCAGAAGGTG AGCGGTGGGT
1761  ATGGACAGGT TGGTAGCGGG CGACTCTGCC TTCCTCCCCA GAAGTTCAGC ATAGCGGTTA AGGGTCGACT CTGGCACCAC
1841  ACTCTTAGGG TTTCAGAACA TGGCTCTGCC ATCGTCTAGC TACACGATCT CAGGAATGTC CATTAGCTTC CCTGTGCCTC
1921  AATTTCCTCA TCTGTACAGT CATGGTAACA CAGTGCCCAG CCCACAGGGC TGTCAGAGCT GCGGGAGCTG GTACACCTGC
2001  CAACGGTGTC TCAGAATTGC CAGTAGTCCA AGCAGCACCC TGTCCTGCCT CTCCTTTCCT CTCTTCACAT TCCAGAAGCG
2081  GCCTTTTATG GTCTTGTGAC CAGCTCCCTG ATCTCAGTGG TGACGTCAGC AGATGAGGAG TATGGTAGCC AGGGACTGAA
2161  GACTGGTGGT CACTCGGGGC AGCTTTCTAA ATAACAATTG GAGTGCCTAC TAGTTTCCTG TGATTGCCAT AACAAATGAT
2241  CACAAATCTG GTGGCCTGAA GCAATAGAAA TCTACCCCCT CAATCTGGAG GCCAGAAATC TGAATAAGCA GGGTGCCACA
2321  GACCGGCACA CCCTCGGAAT GCTGTTGGGG AGGCTCCTTC CGGGTCTCGT CCGCTTTGTG GTGGCTCCAG GCATTCTTTG
2401  ACTTGTGGCC GCTTCACTCC AGGCTCACAC GGCCTTCCCT GTGTGTCTCC TGCAAGGATA CCTATCATTG GTGCATCCAG
2481  GTCATCCAGG ATGATCTCCT CTCAAGACCC TCAGCTTACC TTTGCAAAGA TGCTTTTTCC AAAGAACATT CATGGTTTCA
2561  GCAATTTCAC GTGAACATAC CTTGGGGTGA CATCGTTCAG CCTGCTGTAG GGCAGGATGT GGGATCAACC CTATTTTCTT
2641  CCCTCCCACA ACTCCCCAGC CCCTCCCTCA GTGTCTCCTG CTCTAAGTAG GTAGCTCCAC TACAACTTCC TTTGGCACTT
2721  GAGTCTTCAG TGGGCCACGC CTCCTAGGAC AGTATTAGAG AGCAGGGGGT TTGGCTGAGG TGGAATCAGG CCACTCTTGG
2801  GCATTTGGTG CAGCCCCTTT GCTGCCAGGC GACTCTAGCC TCTACAGAGG ACCTCGTGTA GGCACCTCTG TCCACTCAGC
2881  ACTTGGCGTC TGTGCTGAAA AGCCCTAGGG AGGATTGTGG GGTCGCTTGT CTCCAAACCT ATGGTAAACC GTTCTGTTCT
2961  TTCCTTCCCA GACCTGTGTG CAGCATTTAA CGTCATATGT GATAATGTGG GGAAAGATTG GAGAAGGCTG GCTCGTCAGC
3041  TCAAAGTCTC AGACACCAAG ATCGACAGCA TCGAGGACAG ATACCCCCGC AACCTGACAG AGCGTGTGCG GGAGTCACTG
3121  AGAATCTGGA AGAACACAGA GAAGGAGAAC GCAACAGTGG CCCACCTGGT GGGGGCTCTC AGGTCCTGCC AGATGAACCT
3201  GGTGGCTGAC CTGGTACAAG AGGTTCAGCA GGCCCGTGAC CTCCAGAACA GGAGTGGGGC CATGTCCCCG ATGTCATGGA
3281  ACTCAGACGC ATCTACCTCC GAAGCGTCCT GATGGGCCGC TGCTTTGCGC TGGTGGACCA CAGGCATCTA CACAGCCTGG
3361  ACTTTGGTTC TCTCCAGGAA GGTAGCCCAG CACTGTGAAG ACCCAGCAGG AAGCCAGGCT GAGTGAGCCA CAGACCACCT
3441  GCTTCTGAAC TCAAGCTGCG TTTATTAATG CCTCTCCCGC ACCAGGCCGG GCTTGGGCCC TGCACAGATA TTTCCATTTC
3521  TTCCTCACTA TGACACTGAG CAAGATCTTG TCTCCACTAA ATGAGCTCCT GCGGGAGTAG TTGGAAAGTT GGAACCGTGT
3601  CCAGCACAGA AGGAATCTGT GCAGATGAGC AGTCACACTG TTACTCCACA GCGGAGGAGA CCAGCTCAGA GGCCCAGGAA
3681  TCGGAGCGAA GCAGAGAGGT GGAGAACTGG GATTTGAACC CCCGCCATCC TTCACCAGAG CCCATGCTCA ACCACTGTGG
3761  CGTTCTGCTG CCCCTGCAGT TGGCAGAAAG GATGTTTTGT CCCATTTCCT TGGAGGCCAC CGGGACAGAC CTGGACACTA
3841  GGGTCAGGCG GGGTGCTGTG GTGGGGAGAG GCATGGCTGG GGTGGGGGTG GGGAGACCTG GTTGGCCGTG GTCCAGCTCT
3921  TGGCCCCTGT GTGAGTTGAG TCTCCTCTCT GAGACTGCTA AGTAGGGGCA GTGATGGTTG CCAGGACGAA TTGAGATAAT
4001  ATCTGTGAGG TGCTGATGAG TGATTGACAC ACAGCACTCT CTAAATCTTC CTTGTGAGGA TTATGGGTCC TGCAATTCTA
4081  CAGTTTCTTA CTGTTTTGTA TCAAAATCAC TATCTTTCTG ATAACAGAAT TGCCAAGGCA GCGGGATCTC GTATCTTTAA
4161  AAAGCAGTCC TCTTATTCCT AAGGTAATCC TATTAAAACA CAGCTTTACA ACTTCCATAC TACAAAAAAT TTTCTATTCC
>ref|Gene_ID:8772|FADD|NC_000011.9:70049268...70053507 (+)
AGACGATACGCCGGGCGCAGGCGCAGAAGCCGCGCCCGTCCGCGGCGCCGCCAGCCAGGGCGGAAACGGCTGCGGCTTCG
CTAGGGACGCATGCGCGGGTCCCTTAGTTTTCGCGAGATAACGGTCGAAAACGCGCTCTTGTCGATTTCCTGTAGTGAAT
CAGGCACCGGAGTGCAGGTTCGGGGGTGGAATCCTTGGGCCGCTGGGCAAGCGGCGAGACCTGGCCAGGGCCAGCGAGCC
GAGGACAGAGGGCGCACGGAGGGCCGGGCCGCAGCCCCGGCCGCTTGCAGACCCCGCCATGGACCCGTTCCTGGTGCTGC
TGCACTCGGTGTCGTCCAGCCTGTCGAGCAGCGAGCTGACCGAGCTCAAGTTCCTATGCCTCGGGCGCGTGGGCAAGCGC
AAGCTGGAGCGCGTGCAGAGCGGCCTAGACCTCTTCTCCATGCTGCTGGAGCAGAACGACCTGGAGCCCGGGCACACCGA
GCTCCTGCGCGAGCTGCTCGCCTCCCTGCGGCGCCACGACCTGCTGCGGCGCGTCGACGACTTCGAGGCGGGGGCGGCGG
CCGGGGCCGCGCCTGGGGAAGAAGGTGGGCGCGGGGCCGGGCCGGGGGAGCCAGGGCCTGGTCGCCCGGCTGTAGGTGCT
GCGAGGCTCCTCCGGTTGGCCTCCAGGCGCCTCCCCTTTGCCGGGTTTGATTTGCGTGGGTTTTCTCCGTACAGCCCTGG
TTTTGCAGATGGGAGAGCCAGAAACGCAGAAAAGTTAACTTATTCGAGGTTGCAGGGCGTGGACACGCACAGTCCTTTTT
CCTCCACCCACTTCTGCCCGGGTAAATTAGAAAACTCACTGAAGAAAAGATGAGTCAGAGAAGGTGTGGGGGAGGGGCAG
AGGTTGGGTGAGCCTGCCTCGCATCATTTCCTTTCTGTCTCGGAATATGCTTTTCACGGCTGTCTGAGAGTAATACTAGC
ATTCAGTAACTCCTACCCAGGGGCTTACAGTGTGCCGCTTACCCTTGTAACTGCCAAATACAATTTTCGCAGTAGCCCTG
TGGCTTAGATACTGTTAGCTATCACTGTTCCCATTTTACAGAGGACAGGACTGTGGCTCACAGGTTAAGTGGCTTTGTCG
AAATGCGCAGCCGATAACTGACGGAGCTAGGCTTGAGCCAAGCAGTCCGGCCTCCGGATGGGTAGTGTTAGCCACTACAC
TGCCTCTCTGGTCAAGTTCATTGTGGAGTGGCTTCCTGTCCTGCTCTCGGTCACTCCCTCTCCACCCTCGCCTGTGGATT
GCAGCAGCTTCCAGGATAAAAAAGAAACCCTGAGTACAGCAGAGTTTCTCAGCCCTACCCCCCTTGTTCTCAGAGTCGGG
AGAGGCTTGGGAGTGCTCTGGGGACGCCTCTCAGAGGCTTCAAGCTGTAGCTTGGAATCAGCCATTCAGTCACCAATCAG
ATAGGGCCTAAATGTGTCACCATGGGTTTCACTCTGTAAAGACTGGTGCCTGTTGGGGACAGGATGGACAGAACAGCTCT
CTGCCTGAGAGCAGTCAAGTCCAGATTTTAAAAAAAATCAGTACTGAACAAACAAAACAGGACGTAGAAAAATCGGGTTT
TATGGATATTTAATGTCTGGAAAAACACTGATAAATTGCATTTTAAAGGCGGTCTACGAAACATAGCTGACATTTGAGAT
GTATGTGTGCTTGGTTTTATTTATATCGTCATGTAGTTACTGTGTGCTGGGAAAAGTACACCAGAAGGTGAGCGGTGGGT
ATGGACAGGTTGGTAGCGGGCGACTCTGCCTTCCTCCCCAGAAGTTCAGCATAGCGGTTAAGGGTCGACTCTGGCACCAC
ACTCTTAGGGTTTCAGAACATGGCTCTGCCATCGTCTAGCTACACGATCTCAGGAATGTCCATTAGCTTCCCTGTGCCTC
AATTTCCTCATCTGTACAGTCATGGTAACACAGTGCCCAGCCCACAGGGCTGTCAGAGCTGCGGGAGCTGGTACACCTGC
CAACGGTGTCTCAGAATTGCCAGTAGTCCAAGCAGCACCCTGTCCTGCCTCTCCTTTCCTCTCTTCACATTCCAGAAGCG
GCCTTTTATGGTCTTGTGACCAGCTCCCTGATCTCAGTGGTGACGTCAGCAGATGAGGAGTATGGTAGCCAGGGACTGAA
GACTGGTGGTCACTCGGGGCAGCTTTCTAAATAACAATTGGAGTGCCTACTAGTTTCCTGTGATTGCCATAACAAATGAT
CACAAATCTGGTGGCCTGAAGCAATAGAAATCTACCCCCTCAATCTGGAGGCCAGAAATCTGAATAAGCAGGGTGCCACA
GACCGGCACACCCTCGGAATGCTGTTGGGGAGGCTCCTTCCGGGTCTCGTCCGCTTTGTGGTGGCTCCAGGCATTCTTTG
ACTTGTGGCCGCTTCACTCCAGGCTCACACGGCCTTCCCTGTGTGTCTCCTGCAAGGATACCTATCATTGGTGCATCCAG
GTCATCCAGGATGATCTCCTCTCAAGACCCTCAGCTTACCTTTGCAAAGATGCTTTTTCCAAAGAACATTCATGGTTTCA
GCAATTTCACGTGAACATACCTTGGGGTGACATCGTTCAGCCTGCTGTAGGGCAGGATGTGGGATCAACCCTATTTTCTT
CCCTCCCACAACTCCCCAGCCCCTCCCTCAGTGTCTCCTGCTCTAAGTAGGTAGCTCCACTACAACTTCCTTTGGCACTT
GAGTCTTCAGTGGGCCACGCCTCCTAGGACAGTATTAGAGAGCAGGGGGTTTGGCTGAGGTGGAATCAGGCCACTCTTGG
GCATTTGGTGCAGCCCCTTTGCTGCCAGGCGACTCTAGCCTCTACAGAGGACCTCGTGTAGGCACCTCTGTCCACTCAGC
ACTTGGCGTCTGTGCTGAAAAGCCCTAGGGAGGATTGTGGGGTCGCTTGTCTCCAAACCTATGGTAAACCGTTCTGTTCT
TTCCTTCCCAGACCTGTGTGCAGCATTTAACGTCATATGTGATAATGTGGGGAAAGATTGGAGAAGGCTGGCTCGTCAGC
TCAAAGTCTCAGACACCAAGATCGACAGCATCGAGGACAGATACCCCCGCAACCTGACAGAGCGTGTGCGGGAGTCACTG
AGAATCTGGAAGAACACAGAGAAGGAGAACGCAACAGTGGCCCACCTGGTGGGGGCTCTCAGGTCCTGCCAGATGAACCT
GGTGGCTGACCTGGTACAAGAGGTTCAGCAGGCCCGTGACCTCCAGAACAGGAGTGGGGCCATGTCCCCGATGTCATGGA
ACTCAGACGCATCTACCTCCGAAGCGTCCTGATGGGCCGCTGCTTTGCGCTGGTGGACCACAGGCATCTACACAGCCTGG
ACTTTGGTTCTCTCCAGGAAGGTAGCCCAGCACTGTGAAGACCCAGCAGGAAGCCAGGCTGAGTGAGCCACAGACCACCT
GCTTCTGAACTCAAGCTGCGTTTATTAATGCCTCTCCCGCACCAGGCCGGGCTTGGGCCCTGCACAGATATTTCCATTTC
TTCCTCACTATGACACTGAGCAAGATCTTGTCTCCACTAAATGAGCTCCTGCGGGAGTAGTTGGAAAGTTGGAACCGTGT
CCAGCACAGAAGGAATCTGTGCAGATGAGCAGTCACACTGTTACTCCACAGCGGAGGAGACCAGCTCAGAGGCCCAGGAA
TCGGAGCGAAGCAGAGAGGTGGAGAACTGGGATTTGAACCCCCGCCATCCTTCACCAGAGCCCATGCTCAACCACTGTGG
CGTTCTGCTGCCCCTGCAGTTGGCAGAAAGGATGTTTTGTCCCATTTCCTTGGAGGCCACCGGGACAGACCTGGACACTA
GGGTCAGGCGGGGTGCTGTGGTGGGGAGAGGCATGGCTGGGGTGGGGGTGGGGAGACCTGGTTGGCCGTGGTCCAGCTCT
TGGCCCCTGTGTGAGTTGAGTCTCCTCTCTGAGACTGCTAAGTAGGGGCAGTGATGGTTGCCAGGACGAATTGAGATAAT
ATCTGTGAGGTGCTGATGAGTGATTGACACACAGCACTCTCTAAATCTTCCTTGTGAGGATTATGGGTCCTGCAATTCTA
CAGTTTCTTACTGTTTTGTATCAAAATCACTATCTTTCTGATAACAGAATTGCCAAGGCAGCGGGATCTCGTATCTTTAA
AAAGCAGTCCTCTTATTCCTAAGGTAATCCTATTAAAACACAGCTTTACAACTTCCATACTACAAAAAATTTTCTATTCC