(SPHK1) sphingosine kinase 1 [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  8845
 Official symbol  SPHK1
 Official name  sphingosine kinase 1
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 17 (NC_000017.10) :  74380689...74383940  (+)
 Map  17q25.2
 Length  3252  nt
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Alternative name(s) and Synynom(s) top
Synonyms SPHK
External Links top
Ensembl ENSG00000176170
Entrez 8877
HGNC 11240
HPRD 04768
Comment top
Summary Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM].
Bibliography top
Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
CAGTGCCCTC CCCGCTCCGC GGCGCCGGCT GCGAAGTTGA GCGAAAAGTT TGAGGCCGGA GGGAGCGAGG CCGGGGAGTC
81  CGCTCCAGCG GGGCGCTCCA GTCCCTCAGA CGTGGGCTGA GCTTGGGACG AGCTGCGTTC CGCCCCAGGC CACTGTAGGG
161  AACGGCGGTG GCGCCTCCCC AGCAAACCGG ACCGACTGGG TAGGGCCGCC CACCCTGCCT TCGCGCCGCT CGTGGCTCCT
241  GTGCGGCCCG CCCTCGCGGG GCCCCGGGAA CTGGGCCACT TGTCGCTTGG GCGAGAGCAG GCGGCAGCTG GTGGCCCGGT
321  TCGGGCTTGG CTTTGGCGCG ACCCGGGAGC GGCTCCCACG AGCGCCGCGC GCGTCGCAAC GGAGCGGGGC CCTGAGAAGC
401  GCGCGCCGCG GCTCCCACCG CTCTGGAGCT CCGGGCAGGG GACACGGCAA CCTGGATGGC TGGGGCAGGG ATCCTCTCCC
481  AGAACTTCGT GCCCAGCAAT GTCCGCTCAA GTTCTGGGAT TTTTACGCAG CTGGACTCCC CTCCCCCTGG CAGCCCCGAG
561  GGGTGAGGAG CTAGTCCGTC GGAGGGAGCC ACGGGGCTCT GACTCATCCG TCGGGCCGGA ACCGAACCCC AAGCCCCAGG
641  GAGAAAGCCC CGGAGCAGGC GCCCTTCTCA GGGATTGTAG GCTTAGTCAC ACGGCGGGGG CGCCCTCGGA GGCACCGGAC
721  CTCAGCTCTC TGGACTTCCC GGGAACCTGG CTCCCCGCGC GTGGTCCCGG GATTTAGTCG GGCGCTCCCC ACCTCTGGCA
801  GCTGCGGCCC CGGACTCCGC CAGCGCTGTC TTCTCTCCCT CAGGTCCAGC CGCCGCAGGG AATGACGCCG GTGCTCCTGC
881  AGCCACGGCT CCGGGCGGGG AAGGCGAGCC CCACAGCCGG CCCTGCGACG CCCGCCTGGG CAGCACCGAT AAGGAGCTGA
961  AGGCAGGAGC CGCCGCCACG GGCAGCGCCC CCACAGCGCC AGGGACCCCC TGGCAGCGGG AGCCGCGGGT CGAGGTTATG
1041  GATCCAGGTT TGTGGGGTTC CTGCTGGGAA GGGCTGTAGG GGGATTCCTG TTCCTCGCCA GGAATGATGG AACGCCCAGC
1121  TGGACGAAAG GGGCTGTGGA CGATCGGGAG AAACATTATC CCTCACGAGG CCAGAAGCCG GCCGAATCTG AGCCAAGGAA
1201  GGGGGTGGCA GGGGCGCCGC GTCCCCACCC CAGGTCTCCC AGCAAAGGCC GCTCCTCTGG CCAGGGTCAA TTACCGGGGT
1281  GTTTCGGGCA CCAAGTTCCC ACACTAGTGC CCCATTGTTA CCCGTGGCCC CCTAGTGGTC GGTTGCGGAC GTGGCCTCTT
1361  TGGTTTTGTT TTCTCAGCGG GCGGCCCCCG GGGCGTGCTC CCGCGGCCCT GCCGCGTGCT GGTGCTGCTG AACCCGCGCG
1441  GCGGCAAGGG CAAGGCCTTG CAGCTCTTCC GGAGTCACGT GCAGCCCCTT TTGGCTGAGG CTGAAATCTC CTTCACGCTG
1521  ATGCTCACTG GTGAGTACCT CTCGGAGGGG GTTTCGGGAG CATCCCCTGG CAGGGGACCC CCCCAGTCCT GATAGCTGCC
1601  GGTCTCCCTG CAGAGCGGCG GAACCACGCG CGGGAGCTGG TGCGGTCGGA GGAGCTGGGC CGCTGGGACG CTCTGGTGGT
1681  CATGTCTGGA GACGGGCTGA TGCACGAGGT GAGGACCGCA CTGCGCGGCT AGGCCTGGGG CTTGGCGCGG TGCGTCCCAG
1761  GCTGAGGCCA CGTGTGCTTC AACAGGTGGT GAACGGGCTC ATGGAGCGGC CTGACTGGGA GACCGCCATC CAGAAGCCCC
1841  TGTGTAGCCT CCCAGCAGGC TCTGGCAACG CGCTGGCAGC TTCCTTGAAC CATTATGCTG GGTGAGAGCC CAGGGCCAGA
1921  GTAGGCCTGT TTCCCGTCAG TGCTCCTCTA CCGCGGGGGT TTTCTTGTCT AAGCTCCCAT AGGCTGAGAT CATTTCCATT
2001  TCCCCTTCTC CCTTAGTCCT GGGGCCCTCT CCTGGTGACC CCAGCTGACT GCTTCCATTT GCTCCATCTG TCACCTACCA
2081  GTCCTGCCAA CTCCCCAGGG ACCACATGGC GCTTTGCCAG CTCCCACTCC CCGGGAGGAG GAAGCGGGGG ATACATGGGG
2161  GCTCCTGTCC TGCCTTATCT GACTTTTTCC CCCTGCAGCT ATGAGCAGGT CACCAATGAA GACCTCCTGA CCAACTGCAC
2241  GCTATTGCTG TGCCGCCGGC TGCTGTCACC CATGAACCTG CTGTCTCTGC ACACGGCTTC GGGGCTGCGC CTCTTCTCTG
2321  TGCTCAGCCT GGCCTGGGGC TTCATTGCTG ATGTGGACCT AGAGAGTGAG AAGTATCGGC GTCTGGGGGA GATGCGCTTC
2401  ACTCTGGGCA CCTTCCTGCG TCTGGCAGCC CTGCGCACCT ACCGCGGCCG ACTGGCCTAC CTCCCTGTAG GAAGAGTGGG
2481  TTCCAAGACA CCTGCCTCCC CCGTTGTGGT CCAGCAGGGC CCGGTAGATG CACACCTTGT GCCACTGGAG GAGCCAGTGC
2561  CCTCTCACTG GACAGTGGTG CCCGACGAGG ACTTTGTGCT AGTCCTGGCA CTGCTGCACT CGCACCTGGG CAGTGAGATG
2641  TTTGCTGCAC CCATGGGCCG CTGTGCAGCT GGCGTCATGC ATCTGTTCTA CGTGCGGGCG GGAGTGTCTC GTGCCATGCT
2721  GCTGCGCCTC TTCCTGGCCA TGGAGAAGGG CAGGCATATG GAGTATGAAT GCCCCTACTT GGTATATGTG CCCGTGGTCG
2801  CCTTCCGCTT GGAGCCCAAG GATGGGAAAG GTGTGTTTGC AGTGGATGGG GAATTGATGG TTAGCGAGGC CGTGCAGGGC
2881  CAGGTGCACC CAAACTACTT CTGGATGGTC AGCGGTTGCG TGGAGCCCCC GCCCAGCTGG AAGCCCCAGC AGATGCCACC
2961  GCCAGAAGAG CCCTTATGAC CCCTGGGCCG CGCTGTGCCT TAGTGTCTAC TTGCAGGACC CTTCCTCCTT CCCTAGGGCT
3041  GCAGGGCCTG TCCACAGCTC CTGTGGGGGT GGAGGAGACT CCTCTGGAGA AGGGTGAGAA GGTGGAGGCT ATGCTTTGGG
3121  GGGACAGGCC AGAATGAAGT CCTGGGTCAG GAGCCCAGCT GGCTGGGCCC AGCTGCCTAT GTAAGGCCTT CTAGTTTGTT
3201  CTGAGACCCC CACCCCACGA ACCAAATCCA AATAAAGTGA CATTCCCAGC CT
>ref|Gene_ID:8877|SPHK1|NC_000017.10:74380689...74383940 (+)
CAGTGCCCTCCCCGCTCCGCGGCGCCGGCTGCGAAGTTGAGCGAAAAGTTTGAGGCCGGAGGGAGCGAGGCCGGGGAGTC
CGCTCCAGCGGGGCGCTCCAGTCCCTCAGACGTGGGCTGAGCTTGGGACGAGCTGCGTTCCGCCCCAGGCCACTGTAGGG
AACGGCGGTGGCGCCTCCCCAGCAAACCGGACCGACTGGGTAGGGCCGCCCACCCTGCCTTCGCGCCGCTCGTGGCTCCT
GTGCGGCCCGCCCTCGCGGGGCCCCGGGAACTGGGCCACTTGTCGCTTGGGCGAGAGCAGGCGGCAGCTGGTGGCCCGGT
TCGGGCTTGGCTTTGGCGCGACCCGGGAGCGGCTCCCACGAGCGCCGCGCGCGTCGCAACGGAGCGGGGCCCTGAGAAGC
GCGCGCCGCGGCTCCCACCGCTCTGGAGCTCCGGGCAGGGGACACGGCAACCTGGATGGCTGGGGCAGGGATCCTCTCCC
AGAACTTCGTGCCCAGCAATGTCCGCTCAAGTTCTGGGATTTTTACGCAGCTGGACTCCCCTCCCCCTGGCAGCCCCGAG
GGGTGAGGAGCTAGTCCGTCGGAGGGAGCCACGGGGCTCTGACTCATCCGTCGGGCCGGAACCGAACCCCAAGCCCCAGG
GAGAAAGCCCCGGAGCAGGCGCCCTTCTCAGGGATTGTAGGCTTAGTCACACGGCGGGGGCGCCCTCGGAGGCACCGGAC
CTCAGCTCTCTGGACTTCCCGGGAACCTGGCTCCCCGCGCGTGGTCCCGGGATTTAGTCGGGCGCTCCCCACCTCTGGCA
GCTGCGGCCCCGGACTCCGCCAGCGCTGTCTTCTCTCCCTCAGGTCCAGCCGCCGCAGGGAATGACGCCGGTGCTCCTGC
AGCCACGGCTCCGGGCGGGGAAGGCGAGCCCCACAGCCGGCCCTGCGACGCCCGCCTGGGCAGCACCGATAAGGAGCTGA
AGGCAGGAGCCGCCGCCACGGGCAGCGCCCCCACAGCGCCAGGGACCCCCTGGCAGCGGGAGCCGCGGGTCGAGGTTATG
GATCCAGGTTTGTGGGGTTCCTGCTGGGAAGGGCTGTAGGGGGATTCCTGTTCCTCGCCAGGAATGATGGAACGCCCAGC
TGGACGAAAGGGGCTGTGGACGATCGGGAGAAACATTATCCCTCACGAGGCCAGAAGCCGGCCGAATCTGAGCCAAGGAA
GGGGGTGGCAGGGGCGCCGCGTCCCCACCCCAGGTCTCCCAGCAAAGGCCGCTCCTCTGGCCAGGGTCAATTACCGGGGT
GTTTCGGGCACCAAGTTCCCACACTAGTGCCCCATTGTTACCCGTGGCCCCCTAGTGGTCGGTTGCGGACGTGGCCTCTT
TGGTTTTGTTTTCTCAGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCTGCCGCGTGCTGGTGCTGCTGAACCCGCGCG
GCGGCAAGGGCAAGGCCTTGCAGCTCTTCCGGAGTCACGTGCAGCCCCTTTTGGCTGAGGCTGAAATCTCCTTCACGCTG
ATGCTCACTGGTGAGTACCTCTCGGAGGGGGTTTCGGGAGCATCCCCTGGCAGGGGACCCCCCCAGTCCTGATAGCTGCC
GGTCTCCCTGCAGAGCGGCGGAACCACGCGCGGGAGCTGGTGCGGTCGGAGGAGCTGGGCCGCTGGGACGCTCTGGTGGT
CATGTCTGGAGACGGGCTGATGCACGAGGTGAGGACCGCACTGCGCGGCTAGGCCTGGGGCTTGGCGCGGTGCGTCCCAG
GCTGAGGCCACGTGTGCTTCAACAGGTGGTGAACGGGCTCATGGAGCGGCCTGACTGGGAGACCGCCATCCAGAAGCCCC
TGTGTAGCCTCCCAGCAGGCTCTGGCAACGCGCTGGCAGCTTCCTTGAACCATTATGCTGGGTGAGAGCCCAGGGCCAGA
GTAGGCCTGTTTCCCGTCAGTGCTCCTCTACCGCGGGGGTTTTCTTGTCTAAGCTCCCATAGGCTGAGATCATTTCCATT
TCCCCTTCTCCCTTAGTCCTGGGGCCCTCTCCTGGTGACCCCAGCTGACTGCTTCCATTTGCTCCATCTGTCACCTACCA
GTCCTGCCAACTCCCCAGGGACCACATGGCGCTTTGCCAGCTCCCACTCCCCGGGAGGAGGAAGCGGGGGATACATGGGG
GCTCCTGTCCTGCCTTATCTGACTTTTTCCCCCTGCAGCTATGAGCAGGTCACCAATGAAGACCTCCTGACCAACTGCAC
GCTATTGCTGTGCCGCCGGCTGCTGTCACCCATGAACCTGCTGTCTCTGCACACGGCTTCGGGGCTGCGCCTCTTCTCTG
TGCTCAGCCTGGCCTGGGGCTTCATTGCTGATGTGGACCTAGAGAGTGAGAAGTATCGGCGTCTGGGGGAGATGCGCTTC
ACTCTGGGCACCTTCCTGCGTCTGGCAGCCCTGCGCACCTACCGCGGCCGACTGGCCTACCTCCCTGTAGGAAGAGTGGG
TTCCAAGACACCTGCCTCCCCCGTTGTGGTCCAGCAGGGCCCGGTAGATGCACACCTTGTGCCACTGGAGGAGCCAGTGC
CCTCTCACTGGACAGTGGTGCCCGACGAGGACTTTGTGCTAGTCCTGGCACTGCTGCACTCGCACCTGGGCAGTGAGATG
TTTGCTGCACCCATGGGCCGCTGTGCAGCTGGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGTGCCATGCT
GCTGCGCCTCTTCCTGGCCATGGAGAAGGGCAGGCATATGGAGTATGAATGCCCCTACTTGGTATATGTGCCCGTGGTCG
CCTTCCGCTTGGAGCCCAAGGATGGGAAAGGTGTGTTTGCAGTGGATGGGGAATTGATGGTTAGCGAGGCCGTGCAGGGC
CAGGTGCACCCAAACTACTTCTGGATGGTCAGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAGATGCCACC
GCCAGAAGAGCCCTTATGACCCCTGGGCCGCGCTGTGCCTTAGTGTCTACTTGCAGGACCCTTCCTCCTTCCCTAGGGCT
GCAGGGCCTGTCCACAGCTCCTGTGGGGGTGGAGGAGACTCCTCTGGAGAAGGGTGAGAAGGTGGAGGCTATGCTTTGGG
GGGACAGGCCAGAATGAAGTCCTGGGTCAGGAGCCCAGCTGGCTGGGCCCAGCTGCCTATGTAAGGCCTTCTAGTTTGTT
CTGAGACCCCCACCCCACGAACCAAATCCAAATAAAGTGACATTCCCAGCCT