SPHK1, mRNA isoform 1 - Generality top
	Primary source RefSeq : NM_021972.3 (GI:217330654) Name Sphingosine kinase 1 (SPHK1), transcript variant 1 Type of transcript mRNA Organism Homo sapiens Length 1881 nt Map 17q25.2 Location Chromosome 17 (NC_000017.10)  strand : + 74380689...74380886   74381531...74381734   74382023...74382217   74382301...74382395   74382473...74382588   74382886...74383940
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1a 1 198 198 1 Exon 2b 199 402 204 1 Exon 3a 403 597 195 1 Exon 4 598 692 95 1 Exon 5 693 808 116 1 Exon 6 809 1863 1055 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source rs908721 SNP 97 c/t 1 ? dbSNP rs2247856 SNP 222 a/g 1 ? dbSNP rs8176328 SNP 234 a/g 1 ? dbSNP rs346803 SNP 234 a/g 1 ? dbSNP rs55858018 SNP 251 a/c 1 ? dbSNP rs56342542 SNP 349 c/t 1 ? dbSNP rs12940907 SNP 683 g/t 1 ? dbSNP rs55733020 SNP 718 c/t 1 ? dbSNP rs9901836 SNP 902 c/t 1 ? dbSNP rs17850292 SNP 1030 g/t 1 ? dbSNP rs56104262 SNP 1056 c/g 1 ? dbSNP rs34632043 SNP 1270 a/g 1 ? dbSNP rs3744037 SNP 1397 c/t 1 ? dbSNP rs17851157 SNP 1418 c/t 1 ? dbSNP rs55648239 SNP 1482 a/g 1 ? dbSNP rs346802 SNP 1523 c/t 1 ? dbSNP rs3744039 SNP 1559 g/t 1 ? dbSNP rs3744040 SNP 1560 c/t 1 ? dbSNP rs56341546 SNP 1570 c/t 1 ? dbSNP rs346801 SNP 1600 a/g 1 ? dbSNP rs35262144 insertion 8 -/c 1 ? dbSNP
	CDS top
	Primary source NCBI :  Nucleotide SPHK1, mRNA isoform 1[NM_021972.3] : 393...1589 Length 1197 Location Chromosome 17 (NC_000017.10)  strand : + 74381725...74381734   74382023...74382217   74382301...74382395   74382473...74382588   74382886...74383666   Start codon 1 Translation NP_068807.2
	Sequence top
	FASTA 1  AGTGCCCTCC CCGCTCCGCG GCGCCGGCTG CGAAGTTGAG CGAAAAGTTT GAGGCCGGAG GGAGCGAGGC CGGGGAGTCC 81  GCTCCAGCGG GGCGCTCCAG TCCCTCAGAC GTGGGCTGAG CTTGGGACGA GCTGCGTTCC GCCCCAGGCC ACTGTAGGGA 161  ACGGCGGTGG CGCCTCCCCA GCAAACCGGA CCGACTGGGT CCAGCCGCCG CAGGGAATGA CGCCGGTGCT CCTGCAGCCA 241  CGGCTCCGGG CGGGGAAGGC GAGCCCCACA GCCGGCCCTG CGACGCCCGC CTGGGCAGCA CCGATAAGGA GCTGAAGGCA 321  GGAGCCGCCG CCACGGGCAG CGCCCCCACA GCGCCAGGGA CCCCCTGGCA GCGGGAGCCG CGGGTCGAGG TTATGGATCC 401  AGTGGTCGGT TGCGGACGTG GCCTCTTTGG TTTTGTTTTC TCAGCGGGCG GCCCCCGGGG CGTGCTCCCG CGGCCCTGCC 481  GCGTGCTGGT GCTGCTGAAC CCGCGCGGCG GCAAGGGCAA GGCCTTGCAG CTCTTCCGGA GTCACGTGCA GCCCCTTTTG 561  GCTGAGGCTG AAATCTCCTT CACGCTGATG CTCACTGAGC GGCGGAACCA CGCGCGGGAG CTGGTGCGGT CGGAGGAGCT 641  GGGCCGCTGG GACGCTCTGG TGGTCATGTC TGGAGACGGG CTGATGCACG AGGTGGTGAA CGGGCTCATG GAGCGGCCTG 721  ACTGGGAGAC CGCCATCCAG AAGCCCCTGT GTAGCCTCCC AGCAGGCTCT GGCAACGCGC TGGCAGCTTC CTTGAACCAT 801  TATGCTGGCT ATGAGCAGGT CACCAATGAA GACCTCCTGA CCAACTGCAC GCTATTGCTG TGCCGCCGGC TGCTGTCACC 881  CATGAACCTG CTGTCTCTGC ACACGGCTTC GGGGCTGCGC CTCTTCTCTG TGCTCAGCCT GGCCTGGGGC TTCATTGCTG 961  ATGTGGACCT AGAGAGTGAG AAGTATCGGC GTCTGGGGGA GATGCGCTTC ACTCTGGGCA CCTTCCTGCG TCTGGCAGCC 1041  CTGCGCACCT ACCGCGGCCG ACTGGCCTAC CTCCCTGTAG GAAGAGTGGG TTCCAAGACA CCTGCCTCCC CCGTTGTGGT 1121  CCAGCAGGGC CCGGTAGATG CACACCTTGT GCCACTGGAG GAGCCAGTGC CCTCTCACTG GACAGTGGTG CCCGACGAGG 1201  ACTTTGTGCT AGTCCTGGCA CTGCTGCACT CGCACCTGGG CAGTGAGATG TTTGCTGCAC CCATGGGCCG CTGTGCAGCT 1281  GGCGTCATGC ATCTGTTCTA CGTGCGGGCG GGAGTGTCTC GTGCCATGCT GCTGCGCCTC TTCCTGGCCA TGGAGAAGGG 1361  CAGGCATATG GAGTATGAAT GCCCCTACTT GGTATATGTG CCCGTGGTCG CCTTCCGCTT GGAGCCCAAG GATGGGAAAG 1441  GTGTGTTTGC AGTGGATGGG GAATTGATGG TTAGCGAGGC CGTGCAGGGC CAGGTGCACC CAAACTACTT CTGGATGGTC 1521  AGCGGTTGCG TGGAGCCCCC GCCCAGCTGG AAGCCCCAGC AGATGCCACC GCCAGAAGAG CCCTTATGAC CCCTGGGCCG 1601  CGCTGTGCCT TAGTGTCTAC TTGCAGGACC CTTCCTCCTT CCCTAGGGCT GCAGGGCCTG TCCACAGCTC CTGTGGGGGT 1681  GGAGGAGACT CCTCTGGAGA AGGGTGAGAA GGTGGAGGCT ATGCTTTGGG GGGACAGGCC AGAATGAAGT CCTGGGTCAG 1761  GAGCCCAGCT GGCTGGGCCC AGCTGCCTAT GTAAGGCCTT CTAGTTTGTT CTGAGACCCC CACCCCACGA ACCAAATCCA 1841  AATAAAGTGA CATTCCCAGC CTGAAAAAAA AAAAAAAAAA A >gi|217330654|ref|NM_021972.3|Sphingosine kinase 1 (SPHK1), transcript variant 1 AGTGCCCTCCCCGCTCCGCGGCGCCGGCTGCGAAGTTGAGCGAAAAGTTTGAGGCCGGAGGGAGCGAGGCCGGGGAGTCC GCTCCAGCGGGGCGCTCCAGTCCCTCAGACGTGGGCTGAGCTTGGGACGAGCTGCGTTCCGCCCCAGGCCACTGTAGGGA ACGGCGGTGGCGCCTCCCCAGCAAACCGGACCGACTGGGTCCAGCCGCCGCAGGGAATGACGCCGGTGCTCCTGCAGCCA CGGCTCCGGGCGGGGAAGGCGAGCCCCACAGCCGGCCCTGCGACGCCCGCCTGGGCAGCACCGATAAGGAGCTGAAGGCA GGAGCCGCCGCCACGGGCAGCGCCCCCACAGCGCCAGGGACCCCCTGGCAGCGGGAGCCGCGGGTCGAGGTTATGGATCC AGTGGTCGGTTGCGGACGTGGCCTCTTTGGTTTTGTTTTCTCAGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCTGCC GCGTGCTGGTGCTGCTGAACCCGCGCGGCGGCAAGGGCAAGGCCTTGCAGCTCTTCCGGAGTCACGTGCAGCCCCTTTTG GCTGAGGCTGAAATCTCCTTCACGCTGATGCTCACTGAGCGGCGGAACCACGCGCGGGAGCTGGTGCGGTCGGAGGAGCT GGGCCGCTGGGACGCTCTGGTGGTCATGTCTGGAGACGGGCTGATGCACGAGGTGGTGAACGGGCTCATGGAGCGGCCTG ACTGGGAGACCGCCATCCAGAAGCCCCTGTGTAGCCTCCCAGCAGGCTCTGGCAACGCGCTGGCAGCTTCCTTGAACCAT TATGCTGGCTATGAGCAGGTCACCAATGAAGACCTCCTGACCAACTGCACGCTATTGCTGTGCCGCCGGCTGCTGTCACC CATGAACCTGCTGTCTCTGCACACGGCTTCGGGGCTGCGCCTCTTCTCTGTGCTCAGCCTGGCCTGGGGCTTCATTGCTG ATGTGGACCTAGAGAGTGAGAAGTATCGGCGTCTGGGGGAGATGCGCTTCACTCTGGGCACCTTCCTGCGTCTGGCAGCC CTGCGCACCTACCGCGGCCGACTGGCCTACCTCCCTGTAGGAAGAGTGGGTTCCAAGACACCTGCCTCCCCCGTTGTGGT CCAGCAGGGCCCGGTAGATGCACACCTTGTGCCACTGGAGGAGCCAGTGCCCTCTCACTGGACAGTGGTGCCCGACGAGG ACTTTGTGCTAGTCCTGGCACTGCTGCACTCGCACCTGGGCAGTGAGATGTTTGCTGCACCCATGGGCCGCTGTGCAGCT GGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGTGCCATGCTGCTGCGCCTCTTCCTGGCCATGGAGAAGGG CAGGCATATGGAGTATGAATGCCCCTACTTGGTATATGTGCCCGTGGTCGCCTTCCGCTTGGAGCCCAAGGATGGGAAAG GTGTGTTTGCAGTGGATGGGGAATTGATGGTTAGCGAGGCCGTGCAGGGCCAGGTGCACCCAAACTACTTCTGGATGGTC AGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAGATGCCACCGCCAGAAGAGCCCTTATGACCCCTGGGCCG CGCTGTGCCTTAGTGTCTACTTGCAGGACCCTTCCTCCTTCCCTAGGGCTGCAGGGCCTGTCCACAGCTCCTGTGGGGGT GGAGGAGACTCCTCTGGAGAAGGGTGAGAAGGTGGAGGCTATGCTTTGGGGGGACAGGCCAGAATGAAGTCCTGGGTCAG GAGCCCAGCTGGCTGGGCCCAGCTGCCTATGTAAGGCCTTCTAGTTTGTTCTGAGACCCCCACCCCACGAACCAAATCCA AATAAAGTGACATTCCCAGCCTGAAAAAAAAAAAAAAAAAA

	SPHK1, mRNA isoform 2 - Generality top
	Primary source RefSeq : NM_182965.2 (GI:217272879) Name Sphingosine kinase 1 (SPHK1), transcript variant 2 Type of transcript mRNA Organism Homo sapiens Length 2202 nt Map 17q25.2 Location Chromosome 17 (NC_000017.10)  strand : + 74380689...74381249   74381531...74381734   74382065...74382217   74382301...74382395   74382473...74382588   74382886...74383940
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1b 1 561 561 1 Exon 2b 562 765 204 1 Exon 3b 766 918 153 1 Exon 4 919 1013 95 1 Exon 5 1014 1129 116 1 Exon 6 1130 2184 1055 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source rs34860951 insertion 559 -/g 1 ? dbSNP
	CDS top
	Primary source NCBI : CCDS11744 Nucleotide SPHK1, mRNA isoform 2[NM_182965.2] : 498...1910 Length 1413 Location Chromosome 17 (NC_000017.10)  strand : + 74381186...74381249   74381531...74381734   74382065...74382217   74382301...74382395   74382473...74382588   74382886...74383666   Start codon 1 Translation NP_892010.2
	Sequence top
	FASTA 1  AGTGCCCTCC CCGCTCCGCG GCGCCGGCTG CGAAGTTGAG CGAAAAGTTT GAGGCCGGAG GGAGCGAGGC CGGGGAGTCC 81  GCTCCAGCGG GGCGCTCCAG TCCCTCAGAC GTGGGCTGAG CTTGGGACGA GCTGCGTTCC GCCCCAGGCC ACTGTAGGGA 161  ACGGCGGTGG CGCCTCCCCA GCAAACCGGA CCGACTGGGT AGGGCCGCCC ACCCTGCCTT CGCGCCGCTC GTGGCTCCTG 241  TGCGGCCCGC CCTCGCGGGG CCCCGGGAAC TGGGCCACTT GTCGCTTGGG CGAGAGCAGG CGGCAGCTGG TGGCCCGGTT 321  CGGGCTTGGC TTTGGCGCGA CCCGGGAGCG GCTCCCACGA GCGCCGCGCG CGTCGCAACG GAGCGGGGCC CTGAGAAGCG 401  CGCGCCGCGG CTCCCACCGC TCTGGAGCTC CGGGCAGGGG ACACGGCAAC CTGGATGGCT GGGGCAGGGA TCCTCTCCCA 481  GAACTTCGTG CCCAGCAATG TCCGCTCAAG TTCTGGGATT TTTACGCAGC TGGACTCCCC TCCCCCTGGC AGCCCCGAGG 561  GGTCCAGCCG CCGCAGGGAA TGACGCCGGT GCTCCTGCAG CCACGGCTCC GGGCGGGGAA GGCGAGCCCC ACAGCCGGCC 641  CTGCGACGCC CGCCTGGGCA GCACCGATAA GGAGCTGAAG GCAGGAGCCG CCGCCACGGG CAGCGCCCCC ACAGCGCCAG 721  GGACCCCCTG GCAGCGGGAG CCGCGGGTCG AGGTTATGGA TCCAGCGGGC GGCCCCCGGG GCGTGCTCCC GCGGCCCTGC 801  CGCGTGCTGG TGCTGCTGAA CCCGCGCGGC GGCAAGGGCA AGGCCTTGCA GCTCTTCCGG AGTCACGTGC AGCCCCTTTT 881  GGCTGAGGCT GAAATCTCCT TCACGCTGAT GCTCACTGAG CGGCGGAACC ACGCGCGGGA GCTGGTGCGG TCGGAGGAGC 961  TGGGCCGCTG GGACGCTCTG GTGGTCATGT CTGGAGACGG GCTGATGCAC GAGGTGGTGA ACGGGCTCAT GGAGCGGCCT 1041  GACTGGGAGA CCGCCATCCA GAAGCCCCTG TGTAGCCTCC CAGCAGGCTC TGGCAACGCG CTGGCAGCTT CCTTGAACCA 1121  TTATGCTGGC TATGAGCAGG TCACCAATGA AGACCTCCTG ACCAACTGCA CGCTATTGCT GTGCCGCCGG CTGCTGTCAC 1201  CCATGAACCT GCTGTCTCTG CACACGGCTT CGGGGCTGCG CCTCTTCTCT GTGCTCAGCC TGGCCTGGGG CTTCATTGCT 1281  GATGTGGACC TAGAGAGTGA GAAGTATCGG CGTCTGGGGG AGATGCGCTT CACTCTGGGC ACCTTCCTGC GTCTGGCAGC 1361  CCTGCGCACC TACCGCGGCC GACTGGCCTA CCTCCCTGTA GGAAGAGTGG GTTCCAAGAC ACCTGCCTCC CCCGTTGTGG 1441  TCCAGCAGGG CCCGGTAGAT GCACACCTTG TGCCACTGGA GGAGCCAGTG CCCTCTCACT GGACAGTGGT GCCCGACGAG 1521  GACTTTGTGC TAGTCCTGGC ACTGCTGCAC TCGCACCTGG GCAGTGAGAT GTTTGCTGCA CCCATGGGCC GCTGTGCAGC 1601  TGGCGTCATG CATCTGTTCT ACGTGCGGGC GGGAGTGTCT CGTGCCATGC TGCTGCGCCT CTTCCTGGCC ATGGAGAAGG 1681  GCAGGCATAT GGAGTATGAA TGCCCCTACT TGGTATATGT GCCCGTGGTC GCCTTCCGCT TGGAGCCCAA GGATGGGAAA 1761  GGTGTGTTTG CAGTGGATGG GGAATTGATG GTTAGCGAGG CCGTGCAGGG CCAGGTGCAC CCAAACTACT TCTGGATGGT 1841  CAGCGGTTGC GTGGAGCCCC CGCCCAGCTG GAAGCCCCAG CAGATGCCAC CGCCAGAAGA GCCCTTATGA CCCCTGGGCC 1921  GCGCTGTGCC TTAGTGTCTA CTTGCAGGAC CCTTCCTCCT TCCCTAGGGC TGCAGGGCCT GTCCACAGCT CCTGTGGGGG 2001  TGGAGGAGAC TCCTCTGGAG AAGGGTGAGA AGGTGGAGGC TATGCTTTGG GGGGACAGGC CAGAATGAAG TCCTGGGTCA 2081  GGAGCCCAGC TGGCTGGGCC CAGCTGCCTA TGTAAGGCCT TCTAGTTTGT TCTGAGACCC CCACCCCACG AACCAAATCC 2161  AAATAAAGTG ACATTCCCAG CCTGAAAAAA AAAAAAAAAA AA >gi|217272879|ref|NM_182965.2|Sphingosine kinase 1 (SPHK1), transcript variant 2 AGTGCCCTCCCCGCTCCGCGGCGCCGGCTGCGAAGTTGAGCGAAAAGTTTGAGGCCGGAGGGAGCGAGGCCGGGGAGTCC GCTCCAGCGGGGCGCTCCAGTCCCTCAGACGTGGGCTGAGCTTGGGACGAGCTGCGTTCCGCCCCAGGCCACTGTAGGGA ACGGCGGTGGCGCCTCCCCAGCAAACCGGACCGACTGGGTAGGGCCGCCCACCCTGCCTTCGCGCCGCTCGTGGCTCCTG TGCGGCCCGCCCTCGCGGGGCCCCGGGAACTGGGCCACTTGTCGCTTGGGCGAGAGCAGGCGGCAGCTGGTGGCCCGGTT CGGGCTTGGCTTTGGCGCGACCCGGGAGCGGCTCCCACGAGCGCCGCGCGCGTCGCAACGGAGCGGGGCCCTGAGAAGCG CGCGCCGCGGCTCCCACCGCTCTGGAGCTCCGGGCAGGGGACACGGCAACCTGGATGGCTGGGGCAGGGATCCTCTCCCA GAACTTCGTGCCCAGCAATGTCCGCTCAAGTTCTGGGATTTTTACGCAGCTGGACTCCCCTCCCCCTGGCAGCCCCGAGG GGTCCAGCCGCCGCAGGGAATGACGCCGGTGCTCCTGCAGCCACGGCTCCGGGCGGGGAAGGCGAGCCCCACAGCCGGCC CTGCGACGCCCGCCTGGGCAGCACCGATAAGGAGCTGAAGGCAGGAGCCGCCGCCACGGGCAGCGCCCCCACAGCGCCAG GGACCCCCTGGCAGCGGGAGCCGCGGGTCGAGGTTATGGATCCAGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCTGC CGCGTGCTGGTGCTGCTGAACCCGCGCGGCGGCAAGGGCAAGGCCTTGCAGCTCTTCCGGAGTCACGTGCAGCCCCTTTT GGCTGAGGCTGAAATCTCCTTCACGCTGATGCTCACTGAGCGGCGGAACCACGCGCGGGAGCTGGTGCGGTCGGAGGAGC TGGGCCGCTGGGACGCTCTGGTGGTCATGTCTGGAGACGGGCTGATGCACGAGGTGGTGAACGGGCTCATGGAGCGGCCT GACTGGGAGACCGCCATCCAGAAGCCCCTGTGTAGCCTCCCAGCAGGCTCTGGCAACGCGCTGGCAGCTTCCTTGAACCA TTATGCTGGCTATGAGCAGGTCACCAATGAAGACCTCCTGACCAACTGCACGCTATTGCTGTGCCGCCGGCTGCTGTCAC CCATGAACCTGCTGTCTCTGCACACGGCTTCGGGGCTGCGCCTCTTCTCTGTGCTCAGCCTGGCCTGGGGCTTCATTGCT GATGTGGACCTAGAGAGTGAGAAGTATCGGCGTCTGGGGGAGATGCGCTTCACTCTGGGCACCTTCCTGCGTCTGGCAGC CCTGCGCACCTACCGCGGCCGACTGGCCTACCTCCCTGTAGGAAGAGTGGGTTCCAAGACACCTGCCTCCCCCGTTGTGG TCCAGCAGGGCCCGGTAGATGCACACCTTGTGCCACTGGAGGAGCCAGTGCCCTCTCACTGGACAGTGGTGCCCGACGAG GACTTTGTGCTAGTCCTGGCACTGCTGCACTCGCACCTGGGCAGTGAGATGTTTGCTGCACCCATGGGCCGCTGTGCAGC TGGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGTGCCATGCTGCTGCGCCTCTTCCTGGCCATGGAGAAGG GCAGGCATATGGAGTATGAATGCCCCTACTTGGTATATGTGCCCGTGGTCGCCTTCCGCTTGGAGCCCAAGGATGGGAAA GGTGTGTTTGCAGTGGATGGGGAATTGATGGTTAGCGAGGCCGTGCAGGGCCAGGTGCACCCAAACTACTTCTGGATGGT CAGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAGATGCCACCGCCAGAAGAGCCCTTATGACCCCTGGGCC GCGCTGTGCCTTAGTGTCTACTTGCAGGACCCTTCCTCCTTCCCTAGGGCTGCAGGGCCTGTCCACAGCTCCTGTGGGGG TGGAGGAGACTCCTCTGGAGAAGGGTGAGAAGGTGGAGGCTATGCTTTGGGGGGACAGGCCAGAATGAAGTCCTGGGTCA GGAGCCCAGCTGGCTGGGCCCAGCTGCCTATGTAAGGCCTTCTAGTTTGTTCTGAGACCCCCACCCCACGAACCAAATCC AAATAAAGTGACATTCCCAGCCTGAAAAAAAAAAAAAAAAAA

	SPHK1, mRNA isoform 3 - Generality top
	Primary source RefSeq : NM_001142601.1 (GI:217272882) Name Sphingosine kinase 1 (SPHK1), transcript variant 3 Type of transcript mRNA Organism Homo sapiens Length 1839 nt Map 17q25.2 Location Chromosome 17 (NC_000017.10)  strand : + 74380689...74380886   74381531...74381734   74382065...74382217   74382301...74382395   74382473...74382588   74382886...74383940
	Exon(s) top
	Exon(s) Start End Length is coding Exon 1a 1 198 198 1 Exon 2b 199 402 204 1 Exon 3b 403 555 153 1 Exon 4 556 650 95 1 Exon 5 651 766 116 1 Exon 6 767 1821 1055 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS45785 Nucleotide SPHK1, mRNA isoform 3[NM_001142601.1] : 393...1547 Length 1155 Location Chromosome 17 (NC_000017.10)  strand : + 74381725...74381734   74382065...74382217   74382301...74382395   74382473...74382588   74382886...74383666   Start codon 1 Translation NP_001136073.1
	Sequence top
	FASTA 1  AGTGCCCTCC CCGCTCCGCG GCGCCGGCTG CGAAGTTGAG CGAAAAGTTT GAGGCCGGAG GGAGCGAGGC CGGGGAGTCC 81  GCTCCAGCGG GGCGCTCCAG TCCCTCAGAC GTGGGCTGAG CTTGGGACGA GCTGCGTTCC GCCCCAGGCC ACTGTAGGGA 161  ACGGCGGTGG CGCCTCCCCA GCAAACCGGA CCGACTGGGT CCAGCCGCCG CAGGGAATGA CGCCGGTGCT CCTGCAGCCA 241  CGGCTCCGGG CGGGGAAGGC GAGCCCCACA GCCGGCCCTG CGACGCCCGC CTGGGCAGCA CCGATAAGGA GCTGAAGGCA 321  GGAGCCGCCG CCACGGGCAG CGCCCCCACA GCGCCAGGGA CCCCCTGGCA GCGGGAGCCG CGGGTCGAGG TTATGGATCC 401  AGCGGGCGGC CCCCGGGGCG TGCTCCCGCG GCCCTGCCGC GTGCTGGTGC TGCTGAACCC GCGCGGCGGC AAGGGCAAGG 481  CCTTGCAGCT CTTCCGGAGT CACGTGCAGC CCCTTTTGGC TGAGGCTGAA ATCTCCTTCA CGCTGATGCT CACTGAGCGG 561  CGGAACCACG CGCGGGAGCT GGTGCGGTCG GAGGAGCTGG GCCGCTGGGA CGCTCTGGTG GTCATGTCTG GAGACGGGCT 641  GATGCACGAG GTGGTGAACG GGCTCATGGA GCGGCCTGAC TGGGAGACCG CCATCCAGAA GCCCCTGTGT AGCCTCCCAG 721  CAGGCTCTGG CAACGCGCTG GCAGCTTCCT TGAACCATTA TGCTGGCTAT GAGCAGGTCA CCAATGAAGA CCTCCTGACC 801  AACTGCACGC TATTGCTGTG CCGCCGGCTG CTGTCACCCA TGAACCTGCT GTCTCTGCAC ACGGCTTCGG GGCTGCGCCT 881  CTTCTCTGTG CTCAGCCTGG CCTGGGGCTT CATTGCTGAT GTGGACCTAG AGAGTGAGAA GTATCGGCGT CTGGGGGAGA 961  TGCGCTTCAC TCTGGGCACC TTCCTGCGTC TGGCAGCCCT GCGCACCTAC CGCGGCCGAC TGGCCTACCT CCCTGTAGGA 1041  AGAGTGGGTT CCAAGACACC TGCCTCCCCC GTTGTGGTCC AGCAGGGCCC GGTAGATGCA CACCTTGTGC CACTGGAGGA 1121  GCCAGTGCCC TCTCACTGGA CAGTGGTGCC CGACGAGGAC TTTGTGCTAG TCCTGGCACT GCTGCACTCG CACCTGGGCA 1201  GTGAGATGTT TGCTGCACCC ATGGGCCGCT GTGCAGCTGG CGTCATGCAT CTGTTCTACG TGCGGGCGGG AGTGTCTCGT 1281  GCCATGCTGC TGCGCCTCTT CCTGGCCATG GAGAAGGGCA GGCATATGGA GTATGAATGC CCCTACTTGG TATATGTGCC 1361  CGTGGTCGCC TTCCGCTTGG AGCCCAAGGA TGGGAAAGGT GTGTTTGCAG TGGATGGGGA ATTGATGGTT AGCGAGGCCG 1441  TGCAGGGCCA GGTGCACCCA AACTACTTCT GGATGGTCAG CGGTTGCGTG GAGCCCCCGC CCAGCTGGAA GCCCCAGCAG 1521  ATGCCACCGC CAGAAGAGCC CTTATGACCC CTGGGCCGCG CTGTGCCTTA GTGTCTACTT GCAGGACCCT TCCTCCTTCC 1601  CTAGGGCTGC AGGGCCTGTC CACAGCTCCT GTGGGGGTGG AGGAGACTCC TCTGGAGAAG GGTGAGAAGG TGGAGGCTAT 1681  GCTTTGGGGG GACAGGCCAG AATGAAGTCC TGGGTCAGGA GCCCAGCTGG CTGGGCCCAG CTGCCTATGT AAGGCCTTCT 1761  AGTTTGTTCT GAGACCCCCA CCCCACGAAC CAAATCCAAA TAAAGTGACA TTCCCAGCCT GAAAAAAAAA AAAAAAAAA >gi|217272882|ref|NM_001142601.1|Sphingosine kinase 1 (SPHK1), transcript variant 3 AGTGCCCTCCCCGCTCCGCGGCGCCGGCTGCGAAGTTGAGCGAAAAGTTTGAGGCCGGAGGGAGCGAGGCCGGGGAGTCC GCTCCAGCGGGGCGCTCCAGTCCCTCAGACGTGGGCTGAGCTTGGGACGAGCTGCGTTCCGCCCCAGGCCACTGTAGGGA ACGGCGGTGGCGCCTCCCCAGCAAACCGGACCGACTGGGTCCAGCCGCCGCAGGGAATGACGCCGGTGCTCCTGCAGCCA CGGCTCCGGGCGGGGAAGGCGAGCCCCACAGCCGGCCCTGCGACGCCCGCCTGGGCAGCACCGATAAGGAGCTGAAGGCA GGAGCCGCCGCCACGGGCAGCGCCCCCACAGCGCCAGGGACCCCCTGGCAGCGGGAGCCGCGGGTCGAGGTTATGGATCC AGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCTGCCGCGTGCTGGTGCTGCTGAACCCGCGCGGCGGCAAGGGCAAGG CCTTGCAGCTCTTCCGGAGTCACGTGCAGCCCCTTTTGGCTGAGGCTGAAATCTCCTTCACGCTGATGCTCACTGAGCGG CGGAACCACGCGCGGGAGCTGGTGCGGTCGGAGGAGCTGGGCCGCTGGGACGCTCTGGTGGTCATGTCTGGAGACGGGCT GATGCACGAGGTGGTGAACGGGCTCATGGAGCGGCCTGACTGGGAGACCGCCATCCAGAAGCCCCTGTGTAGCCTCCCAG CAGGCTCTGGCAACGCGCTGGCAGCTTCCTTGAACCATTATGCTGGCTATGAGCAGGTCACCAATGAAGACCTCCTGACC AACTGCACGCTATTGCTGTGCCGCCGGCTGCTGTCACCCATGAACCTGCTGTCTCTGCACACGGCTTCGGGGCTGCGCCT CTTCTCTGTGCTCAGCCTGGCCTGGGGCTTCATTGCTGATGTGGACCTAGAGAGTGAGAAGTATCGGCGTCTGGGGGAGA TGCGCTTCACTCTGGGCACCTTCCTGCGTCTGGCAGCCCTGCGCACCTACCGCGGCCGACTGGCCTACCTCCCTGTAGGA AGAGTGGGTTCCAAGACACCTGCCTCCCCCGTTGTGGTCCAGCAGGGCCCGGTAGATGCACACCTTGTGCCACTGGAGGA GCCAGTGCCCTCTCACTGGACAGTGGTGCCCGACGAGGACTTTGTGCTAGTCCTGGCACTGCTGCACTCGCACCTGGGCA GTGAGATGTTTGCTGCACCCATGGGCCGCTGTGCAGCTGGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGT GCCATGCTGCTGCGCCTCTTCCTGGCCATGGAGAAGGGCAGGCATATGGAGTATGAATGCCCCTACTTGGTATATGTGCC CGTGGTCGCCTTCCGCTTGGAGCCCAAGGATGGGAAAGGTGTGTTTGCAGTGGATGGGGAATTGATGGTTAGCGAGGCCG TGCAGGGCCAGGTGCACCCAAACTACTTCTGGATGGTCAGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAG ATGCCACCGCCAGAAGAGCCCTTATGACCCCTGGGCCGCGCTGTGCCTTAGTGTCTACTTGCAGGACCCTTCCTCCTTCC CTAGGGCTGCAGGGCCTGTCCACAGCTCCTGTGGGGGTGGAGGAGACTCCTCTGGAGAAGGGTGAGAAGGTGGAGGCTAT GCTTTGGGGGGACAGGCCAGAATGAAGTCCTGGGTCAGGAGCCCAGCTGGCTGGGCCCAGCTGCCTATGTAAGGCCTTCT AGTTTGTTCTGAGACCCCCACCCCACGAACCAAATCCAAATAAAGTGACATTCCCAGCCTGAAAAAAAAAAAAAAAAAA

	SPHK1, mRNA isoform 4 - Generality top
	Primary source RefSeq : NM_001142602.1 (GI:217272884) Name Sphingosine kinase 1 (SPHK1), transcript variant 4 Type of transcript mRNA Organism Homo sapiens Length 1884 nt Map 17q25.2 Location Chromosome 17 (NC_000017.10)  strand : + 74381288...74381734   74382065...74382217   74382301...74382395   74382473...74382588   74382886...74383940
	Exon(s) top
	Exon(s) Start End Length is coding Exon 2a 1 447 447 1 Exon 3b 448 600 153 1 Exon 4 601 695 95 1 Exon 5 696 811 116 1 Exon 6 812 1866 1055 1
	Variation(s) top
	ID Class Location Mutation Length is synonymous Source
	CDS top
	Primary source NCBI : CCDS45785 Nucleotide SPHK1, mRNA isoform 4[NM_001142602.1] : 438...1592 Length 1155 Location Chromosome 17 (NC_000017.10)  strand : + 74381725...74381734   74382065...74382217   74382301...74382395   74382473...74382588   74382886...74383666   Start codon 1 Translation NP_001136074.1
	Sequence top
	FASTA 1  GACTCATCCG TCGGGCCGGA ACCGAACCCC AAGCCCCAGG GAGAAAGCCC CGGAGCAGGC GCCCTTCTCA GGGATTGTAG 81  GCTTAGTCAC ACGGCGGGGG CGCCCTCGGA GGCACCGGAC CTCAGCTCTC TGGACTTCCC GGGAACCTGG CTCCCCGCGC 161  GTGGTCCCGG GATTTAGTCG GGCGCTCCCC ACCTCTGGCA GCTGCGGCCC CGGACTCCGC CAGCGCTGTC TTCTCTCCCT 241  CAGGTCCAGC CGCCGCAGGG AATGACGCCG GTGCTCCTGC AGCCACGGCT CCGGGCGGGG AAGGCGAGCC CCACAGCCGG 321  CCCTGCGACG CCCGCCTGGG CAGCACCGAT AAGGAGCTGA AGGCAGGAGC CGCCGCCACG GGCAGCGCCC CCACAGCGCC 401  AGGGACCCCC TGGCAGCGGG AGCCGCGGGT CGAGGTTATG GATCCAGCGG GCGGCCCCCG GGGCGTGCTC CCGCGGCCCT 481  GCCGCGTGCT GGTGCTGCTG AACCCGCGCG GCGGCAAGGG CAAGGCCTTG CAGCTCTTCC GGAGTCACGT GCAGCCCCTT 561  TTGGCTGAGG CTGAAATCTC CTTCACGCTG ATGCTCACTG AGCGGCGGAA CCACGCGCGG GAGCTGGTGC GGTCGGAGGA 641  GCTGGGCCGC TGGGACGCTC TGGTGGTCAT GTCTGGAGAC GGGCTGATGC ACGAGGTGGT GAACGGGCTC ATGGAGCGGC 721  CTGACTGGGA GACCGCCATC CAGAAGCCCC TGTGTAGCCT CCCAGCAGGC TCTGGCAACG CGCTGGCAGC TTCCTTGAAC 801  CATTATGCTG GCTATGAGCA GGTCACCAAT GAAGACCTCC TGACCAACTG CACGCTATTG CTGTGCCGCC GGCTGCTGTC 881  ACCCATGAAC CTGCTGTCTC TGCACACGGC TTCGGGGCTG CGCCTCTTCT CTGTGCTCAG CCTGGCCTGG GGCTTCATTG 961  CTGATGTGGA CCTAGAGAGT GAGAAGTATC GGCGTCTGGG GGAGATGCGC TTCACTCTGG GCACCTTCCT GCGTCTGGCA 1041  GCCCTGCGCA CCTACCGCGG CCGACTGGCC TACCTCCCTG TAGGAAGAGT GGGTTCCAAG ACACCTGCCT CCCCCGTTGT 1121  GGTCCAGCAG GGCCCGGTAG ATGCACACCT TGTGCCACTG GAGGAGCCAG TGCCCTCTCA CTGGACAGTG GTGCCCGACG 1201  AGGACTTTGT GCTAGTCCTG GCACTGCTGC ACTCGCACCT GGGCAGTGAG ATGTTTGCTG CACCCATGGG CCGCTGTGCA 1281  GCTGGCGTCA TGCATCTGTT CTACGTGCGG GCGGGAGTGT CTCGTGCCAT GCTGCTGCGC CTCTTCCTGG CCATGGAGAA 1361  GGGCAGGCAT ATGGAGTATG AATGCCCCTA CTTGGTATAT GTGCCCGTGG TCGCCTTCCG CTTGGAGCCC AAGGATGGGA 1441  AAGGTGTGTT TGCAGTGGAT GGGGAATTGA TGGTTAGCGA GGCCGTGCAG GGCCAGGTGC ACCCAAACTA CTTCTGGATG 1521  GTCAGCGGTT GCGTGGAGCC CCCGCCCAGC TGGAAGCCCC AGCAGATGCC ACCGCCAGAA GAGCCCTTAT GACCCCTGGG 1601  CCGCGCTGTG CCTTAGTGTC TACTTGCAGG ACCCTTCCTC CTTCCCTAGG GCTGCAGGGC CTGTCCACAG CTCCTGTGGG 1681  GGTGGAGGAG ACTCCTCTGG AGAAGGGTGA GAAGGTGGAG GCTATGCTTT GGGGGGACAG GCCAGAATGA AGTCCTGGGT 1761  CAGGAGCCCA GCTGGCTGGG CCCAGCTGCC TATGTAAGGC CTTCTAGTTT GTTCTGAGAC CCCCACCCCA CGAACCAAAT 1841  CCAAATAAAG TGACATTCCC AGCCTGAAAA AAAAAAAAAA AAAA >gi|217272884|ref|NM_001142602.1|Sphingosine kinase 1 (SPHK1), transcript variant 4 GACTCATCCGTCGGGCCGGAACCGAACCCCAAGCCCCAGGGAGAAAGCCCCGGAGCAGGCGCCCTTCTCAGGGATTGTAG GCTTAGTCACACGGCGGGGGCGCCCTCGGAGGCACCGGACCTCAGCTCTCTGGACTTCCCGGGAACCTGGCTCCCCGCGC GTGGTCCCGGGATTTAGTCGGGCGCTCCCCACCTCTGGCAGCTGCGGCCCCGGACTCCGCCAGCGCTGTCTTCTCTCCCT CAGGTCCAGCCGCCGCAGGGAATGACGCCGGTGCTCCTGCAGCCACGGCTCCGGGCGGGGAAGGCGAGCCCCACAGCCGG CCCTGCGACGCCCGCCTGGGCAGCACCGATAAGGAGCTGAAGGCAGGAGCCGCCGCCACGGGCAGCGCCCCCACAGCGCC AGGGACCCCCTGGCAGCGGGAGCCGCGGGTCGAGGTTATGGATCCAGCGGGCGGCCCCCGGGGCGTGCTCCCGCGGCCCT GCCGCGTGCTGGTGCTGCTGAACCCGCGCGGCGGCAAGGGCAAGGCCTTGCAGCTCTTCCGGAGTCACGTGCAGCCCCTT TTGGCTGAGGCTGAAATCTCCTTCACGCTGATGCTCACTGAGCGGCGGAACCACGCGCGGGAGCTGGTGCGGTCGGAGGA GCTGGGCCGCTGGGACGCTCTGGTGGTCATGTCTGGAGACGGGCTGATGCACGAGGTGGTGAACGGGCTCATGGAGCGGC CTGACTGGGAGACCGCCATCCAGAAGCCCCTGTGTAGCCTCCCAGCAGGCTCTGGCAACGCGCTGGCAGCTTCCTTGAAC CATTATGCTGGCTATGAGCAGGTCACCAATGAAGACCTCCTGACCAACTGCACGCTATTGCTGTGCCGCCGGCTGCTGTC ACCCATGAACCTGCTGTCTCTGCACACGGCTTCGGGGCTGCGCCTCTTCTCTGTGCTCAGCCTGGCCTGGGGCTTCATTG CTGATGTGGACCTAGAGAGTGAGAAGTATCGGCGTCTGGGGGAGATGCGCTTCACTCTGGGCACCTTCCTGCGTCTGGCA GCCCTGCGCACCTACCGCGGCCGACTGGCCTACCTCCCTGTAGGAAGAGTGGGTTCCAAGACACCTGCCTCCCCCGTTGT GGTCCAGCAGGGCCCGGTAGATGCACACCTTGTGCCACTGGAGGAGCCAGTGCCCTCTCACTGGACAGTGGTGCCCGACG AGGACTTTGTGCTAGTCCTGGCACTGCTGCACTCGCACCTGGGCAGTGAGATGTTTGCTGCACCCATGGGCCGCTGTGCA GCTGGCGTCATGCATCTGTTCTACGTGCGGGCGGGAGTGTCTCGTGCCATGCTGCTGCGCCTCTTCCTGGCCATGGAGAA GGGCAGGCATATGGAGTATGAATGCCCCTACTTGGTATATGTGCCCGTGGTCGCCTTCCGCTTGGAGCCCAAGGATGGGA AAGGTGTGTTTGCAGTGGATGGGGAATTGATGGTTAGCGAGGCCGTGCAGGGCCAGGTGCACCCAAACTACTTCTGGATG GTCAGCGGTTGCGTGGAGCCCCCGCCCAGCTGGAAGCCCCAGCAGATGCCACCGCCAGAAGAGCCCTTATGACCCCTGGG CCGCGCTGTGCCTTAGTGTCTACTTGCAGGACCCTTCCTCCTTCCCTAGGGCTGCAGGGCCTGTCCACAGCTCCTGTGGG GGTGGAGGAGACTCCTCTGGAGAAGGGTGAGAAGGTGGAGGCTATGCTTTGGGGGGACAGGCCAGAATGAAGTCCTGGGT CAGGAGCCCAGCTGGCTGGGCCCAGCTGCCTATGTAAGGCCTTCTAGTTTGTTCTGAGACCCCCACCCCACGAACCAAAT CCAAATAAAGTGACATTCCCAGCCTGAAAAAAAAAAAAAAAAAA

	Q9NYA1 - Generality top
	Primary source Uniprot : Q9NYA1 Name Sphingosine kinase 1 Alternative name(s) Synonym(s) SK 1 SPK 1 Organism Homo sapiens Length 384 aa Protein existence ---
	External Links top
	ArrayExpress Q9NYA1   BRENDA 2.7.1.91   Smart SM00046   Refseq NP_892010.2   NP_068807.2   NP_001136074.1   NP_001136073.1   Uniprot Q9NYA1   EBI EBI-985303   InterPro IPR001206   KEGG hsa:8877   PROSITE PS50146   Pfam PF00781
	General annotation (Comments) top
	Catalytic activity ATP + sphinganine = ADP + sphinganine 1- phosphate. ATP + sphingosine = ADP + sphingosine 1- phosphate. Cofactor Magnesium. Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. Similarity Contains 1 DAGKc domain. Subunit Interacts with ACY1 (By similarity). Binds to calmodulin. Interacts with SPHKAP. Tissue specificity Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.
	Ontologies top
	Biological process sphingosine metabolic process [GO:0006670] anti-apoptosis [GO:0006916] activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [GO:0007205] calcium-mediated signaling [GO:0019722] positive regulation of cell growth [GO:0030307] positive regulation of cell migration [GO:0030335] positive regulation of angiogenesis [GO:0045766] positive regulation of mitotic cell cycle [GO:0045931] positive regulation of smooth muscle contraction [GO:0045987] sphingoid catabolic process [GO:0046521] positive regulation of fibroblast proliferation [GO:0048146] Cellular component membrane fraction [GO:0005624] soluble fraction [GO:0005625] cytosol [GO:0005829] Molecular function magnesium ion binding [GO:0000287] DNA binding [GO:0003677] diacylglycerol kinase activity [GO:0004143] calmodulin binding [GO:0005516] ATP binding [GO:0005524] sphinganine kinase activity [GO:0008481] D-erythro-sphingosine kinase activity [GO:0017050]
	Binary interactions top
	With Uniprot accession IntAct FHL2 Q14192 EBI-985303,EBI-701903 SPHKAP Q2M3C7 EBI-985303,EBI-1803914 FYN P06241 EBI-985303,EBI-515315
	Alternative product(s) top
	Uniprot Identifier Difference(s) with the 'canonical' sequence Notes Sequences Isoform 1 Q9NYA1-1 --- 'Canonical' sequence Get Fasta Isoform 2 Q9NYA1-2 1-1  :  M -> MSAQVLGFLRSWTPLPLAAPRGPAAAGNDAGAPTAT APGGEGEPHSRPCDARLGSTDKELKAGAAATGSAPTAPGTP WQREPRVEVM --- Get Fasta
	Sequence annotation top
	Feature key Position Length Description Feature identifier Region           Domain 12 - 159 148 DAGKc Q9NYA1-DOMAIN-12 Natural variations           Alternative sequence 1 - 1 1 M -> MSAQVLGFLRSWTPLPLAAPRGPAAAGNDAGAPTAT APGGEGEPHSRPCDARLGSTDKELKAGAAATGSAPTAPGTP WQREPRVEVM VSP_035453 Amino acid modifications           Modified residue 193 - 193 1 Phosphothreonine Q9NYA1-MOD_RES-193 Modified residue 225 - 225 1 Phosphoserine (By similarity) Q9NYA1-MOD_RES-225
	Sequence top
	FASTA 1  MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT LMLTERRNHA RELVRSEELG RWDALVVMSG 81  DGLMHEVVNG LMERPDWETA IQKPLCSLPA GSGNALAASL NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM NLLSLHTASG 161  LRLFSVLSLA WGFIADVDLE SEKYRRLGEM RFTLGTFLRL AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP 241  LEEPVPSHWT VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL RLFLAMEKGR HMEYECPYLV 321  YVPVVAFRLE PKDGKGVFAV DGELMVSEAV QGQVHPNYFW MVSGCVEPPP SWKPQQMPPP EEPL >sp|Q9NYA1|SPHK1_human Sphingosine kinase 1 MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSG DGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASG LRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLV YVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL

	Q96GK1 - Generality top
	Primary source Uniprot : Q96GK1 Name Sphingosine kinase 1 [submitted name] Alternative name(s) Sphingosine kinase 1, isoform CRA_c [submitted name] Synonym(s) Organism Homo sapiens Length 398 aa Protein existence ---
	External Links top
	ArrayExpress Q96GK1   Smart SM00046   Refseq NP_892010.2   NP_068807.2   NP_001136074.1   NP_001136073.1   Uniprot Q96GK1   InterPro IPR001206   KEGG hsa:8877   PROSITE PS50146   Pfam PF00781
	General annotation (Comments) top
	Ontologies top
	Biological process activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [GO:0007205] Molecular function magnesium ion binding [GO:0000287] diacylglycerol kinase activity [GO:0004143] D-erythro-sphingosine kinase activity [GO:0017050]
	Binary interactions top
	With Uniprot accession IntAct
	Alternative product(s) top
	Sequence annotation top
	Feature key Position Length Description Feature identifier
	Sequence top
	FASTA 1  MDPVVGCGRG LFGFVFSAGG PRGVLPRPCR VLVLLNPRGG KGKALQLFRS HVQPLLAEAE ISFTLMLTER RNHARELVRS 81  EELGRWDALV VMSGDGLMHE VVNGLMERPD WETAIQKPLC SLPAGSGNAL AASLNHYAGY EQVTNEDLLT NCTLLLCRRL 161  LSPMNLLSLH TASGLRLFSV LSLAWGFIAD VDLESEKYRR LGEMRFTLGT FLRLAALRTY RGRLAYLPVG RVGSKTPASP 241  VVVQQGPVDA HLVPLEEPVP SHWTVVPDED FVLVLALLHS HLGSEMFAAP MGRCAAGVMH LFYVRAGVSR AMLLRLFLAM 321  EKGRHMEYEC PYLVYVPVVA FRLEPKDGKG VFAVDGELMV SEAVQGQVHP NYFWMVSGCV EPPPSWKPQQ MPPPEEPL >sp|Q96GK1|Q96GK1_human Sphingosine kinase 1 [submitted name] MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRS EELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRL LSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASP VVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAM EKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL

	Q53ZR5 - Generality top
	Primary source Uniprot : Q53ZR5 Name Sphingosine kinase 1 [submitted name] Alternative name(s) Sphingosine kinase 1, isoform CRA_a [submitted name] cDNA FLJ78254 [submitted name] Synonym(s) Organism Homo sapiens Length 384 aa Protein existence ---
	External Links top
	ArrayExpress Q53ZR5   Smart SM00046   Refseq NP_001136074.1   NP_001136073.1   Uniprot Q53ZR5   InterPro IPR001206   KEGG hsa:8877   PROSITE PS50146   Pfam PF00781
	General annotation (Comments) top
	Ontologies top
	Biological process activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [GO:0007205] Molecular function diacylglycerol kinase activity [GO:0004143]
	Binary interactions top
	With Uniprot accession IntAct
	Alternative product(s) top
	Sequence annotation top
	Feature key Position Length Description Feature identifier
	Sequence top
	FASTA 1  MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT LMLTERRNHA RELVRSEELG RWDALVVMSG 81  DGLMHEVVNG LMERPDWETA IQKPLCSLPA GSGNALAASL NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM NLLSLHTASG 161  LRLFSVLSLA WGFIADVDLE SEKYRRLGEM RFTLGTFLRL AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP 241  LEEPVPSHWT VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL RLFLAMEKGR HMEYECPYLV 321  YVPVVAFRLE PKDGKGVFAV DGELMVSEAV QGQVHPNYFW MVSGCVEPPP SWKPQQMPPP EEPL >sp|Q53ZR5|Q53ZR5_human Sphingosine kinase 1 [submitted name] MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSG DGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASG LRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLV YVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL