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TANK

TRAF family member associated NFKB activator
General Information
Name TRAF family member associated NFKB activator
Alias
  • TRAF family member-associated NF-kappa-B activator
  • TRAF-interacting protein
Gene_family
organism Homo sapiens
entrez_id 10010
location 2q24.2
transcript_count 13
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
    Stringdb TRAF family member-associated NF-kappa-B activator; Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation t [...]
    nextProt Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TANK BioGRID ATG16L1 GeneID BioGRID Proximity Label-MS
TANK BioGRID TBK1 GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS; Two-hybrid
TANK BioGRID WEE2-AS1 GeneID BioGRID Protein-RNA
TANK BioGRID TIPARP GeneID BioGRID Affinity Capture-MS
TANK BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
TANK BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID IKBKG GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TANK BioGRID HNRNPH1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CSNK2A2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TRAF3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex; Two-hybrid
TANK BioGRID HVCN1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ARB2A GeneID BioGRID Affinity Capture-MS
TANK BioGRID FBXO38 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TNIP2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID DIABLO GeneID BioGRID Affinity Capture-MS
TANK BioGRID CENPQ GeneID BioGRID Affinity Capture-MS
TANK BioGRID TRAF5 GeneID BioGRID Affinity Capture-MS; Protein-peptide
TANK BioGRID TRAF2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
TANK BioGRID TRAF1 GeneID BioGRID Affinity Capture-MS; Co-crystal Structure; Protein-peptide; Two-hybrid
TANK BioGRID PLK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TANK BioGRID SEPTIN2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID NUP62 GeneID BioGRID Affinity Capture-MS
TANK BioGRID IKBKE GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TANK BioGRID BBOX1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID BIRC2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TSC1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TANK BioGRID TRIM37 GeneID BioGRID Proximity Label-MS
TANK BioGRID ORF6 GeneID BioGRID Affinity Capture-MS
TANK BioGRID OBSL1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID BICD2 GeneID BioGRID Proximity Label-MS
TANK BioGRID BICD1 GeneID BioGRID Proximity Label-MS
TANK BioGRID TNFRSF1A GeneID BioGRID Affinity Capture-MS
TANK BioGRID TNF GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TANK BioGRID KRT80 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ZFAND2B GeneID BioGRID Affinity Capture-MS
TANK BioGRID IQGAP3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SNAP47 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TBC1D31 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ZNF598 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CEP95 GeneID BioGRID Affinity Capture-MS
TANK BioGRID KIF7 GeneID BioGRID Affinity Capture-MS
TANK BioGRID KRT79 GeneID BioGRID Affinity Capture-MS
TANK BioGRID H3C15 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TXLNA GeneID BioGRID Affinity Capture-MS
TANK BioGRID OIT3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CCDC138 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SASS6 GeneID BioGRID Affinity Capture-MS
TANK BioGRID AMOTL1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID AMOT GeneID BioGRID Affinity Capture-MS
TANK BioGRID CCDC112 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CCDC50 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SAPCD2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID UBASH3B GeneID BioGRID Affinity Capture-MS
TANK BioGRID CCDC77 GeneID BioGRID Affinity Capture-MS
TANK BioGRID NTPCR GeneID BioGRID Affinity Capture-MS
TANK BioGRID NAA50 GeneID BioGRID Affinity Capture-MS
TANK BioGRID DYNC2H1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ULBP3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID NOC4L GeneID BioGRID Affinity Capture-MS
TANK BioGRID AHNAK GeneID BioGRID Affinity Capture-MS
TANK BioGRID NOL6 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SCPEP1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID MEAK7 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SH3RF1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID MIB1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PELI1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID FAM20C GeneID BioGRID Affinity Capture-MS
TANK BioGRID OTUD7B GeneID BioGRID Affinity Capture-MS
TANK BioGRID BAIAP2L1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID UTP6 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TXLNG GeneID BioGRID Affinity Capture-MS
TANK BioGRID PARVA GeneID BioGRID Affinity Capture-MS
TANK BioGRID TENM3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID YOD1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID UEVLD GeneID BioGRID Affinity Capture-MS
TANK BioGRID HEATR1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PLEKHB2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID NCAPG2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SDK2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TRMT6 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ANAPC7 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ERO1A GeneID BioGRID Affinity Capture-MS
TANK BioGRID EIF3K GeneID BioGRID Affinity Capture-MS
TANK BioGRID RNF115 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SDCBP2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CKAP2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID GPSM1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID GIGYF2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID MOXD1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ULK3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CNOT10 GeneID BioGRID Affinity Capture-MS
TANK BioGRID INTS7 GeneID BioGRID Affinity Capture-MS
TANK BioGRID NCS1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CNOT1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CEP131 GeneID BioGRID Affinity Capture-MS
TANK BioGRID DNAJB4 GeneID BioGRID Affinity Capture-MS
TANK BioGRID KIF2C GeneID BioGRID Affinity Capture-MS
TANK BioGRID HAX1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TNIP1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID RNF41 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TANK GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS; Protein-peptide; Reconstituted Complex
TANK BioGRID OXSR1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
TANK BioGRID MRC2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TELO2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CEP135 GeneID BioGRID Affinity Capture-MS
TANK BioGRID IQCB1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TRAF4 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PICK1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID RAB9A GeneID BioGRID Affinity Capture-MS
TANK BioGRID CACNA2D2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CNOT9 GeneID BioGRID Affinity Capture-MS
TANK BioGRID FUBP3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID FADD GeneID BioGRID Affinity Capture-MS
TANK BioGRID MBTPS1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SSNA1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID OFD1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TRIP6 GeneID BioGRID Affinity Capture-MS
TANK BioGRID TNFAIP3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ELOC GeneID BioGRID Affinity Capture-MS
TANK BioGRID STK10 GeneID BioGRID Affinity Capture-MS
TANK BioGRID HSPA13 GeneID BioGRID Affinity Capture-MS
TANK BioGRID SPRR1B GeneID BioGRID Affinity Capture-MS
TANK BioGRID SERPINB4 GeneID BioGRID Affinity Capture-MS
TANK BioGRID RFC4 GeneID BioGRID Affinity Capture-MS
TANK BioGRID RFC3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PRSS3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PKN2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PRIM1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PPT1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PPP2R5D GeneID BioGRID Affinity Capture-MS
TANK BioGRID PLEC GeneID BioGRID Affinity Capture-MS
TANK BioGRID SERPINB5 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PFDN5 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PFDN4 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PDPK1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PCSK5 GeneID BioGRID Affinity Capture-MS
TANK BioGRID PAFAH1B1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID OGN GeneID BioGRID Affinity Capture-MS
TANK BioGRID CNOT3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID NF2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID NEK2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID MLF1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID MDH2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID KRT15 GeneID BioGRID Affinity Capture-MS
TANK BioGRID KIF5C GeneID BioGRID Affinity Capture-MS
TANK BioGRID IVL GeneID BioGRID Affinity Capture-MS
TANK BioGRID IKBKB GeneID BioGRID Affinity Capture-MS
TANK BioGRID IGKC GeneID BioGRID Affinity Capture-MS
TANK BioGRID JCHAIN GeneID BioGRID Affinity Capture-MS
TANK BioGRID IGHG1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID IGHA1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID HSPA2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID HABP2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID GSK3B GeneID BioGRID Affinity Capture-MS
TANK BioGRID GSK3A GeneID BioGRID Affinity Capture-MS
TANK BioGRID GDI1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID EPS8 GeneID BioGRID Affinity Capture-MS
TANK BioGRID EPHB4 GeneID BioGRID Affinity Capture-MS
TANK BioGRID EIF4G2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CSNK1D GeneID BioGRID Affinity Capture-MS
TANK BioGRID CSNK1A1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CNTFR GeneID BioGRID Affinity Capture-MS
TANK BioGRID CHUK GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TANK BioGRID CETN3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CDC6 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CAMK2B GeneID BioGRID Affinity Capture-MS
TANK BioGRID CALML3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ATP5F1B GeneID BioGRID Affinity Capture-MS
TANK BioGRID ATP5F1A GeneID BioGRID Affinity Capture-MS
TANK BioGRID ANXA4 GeneID BioGRID Affinity Capture-MS
TANK BioGRID AP2A1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ADSS2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ACTG1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CD40 GeneID BioGRID Affinity Capture-Western; Protein-peptide
TANK BioGRID C9orf72 GeneID BioGRID Affinity Capture-Western
TANK BioGRID HIF1AN GeneID BioGRID Affinity Capture-MS
TANK BioGRID PBXIP1 GeneID BioGRID Affinity Capture-Western
TANK BioGRID ZC3H12A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TANK BioGRID USP10 GeneID BioGRID Affinity Capture-Western
TANK BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TANK BioGRID CEP128 GeneID BioGRID Proximity Label-MS
TANK BioGRID CEP63 GeneID BioGRID Proximity Label-MS; Two-hybrid
TANK BioGRID SUMO2 GeneID BioGRID Affinity Capture-Western
TANK BioGRID ZFP36 GeneID BioGRID Affinity Capture-RNA
TANK BioGRID TP53BP2 GeneID BioGRID Two-hybrid
TANK BioGRID SRSF11 GeneID BioGRID Two-hybrid
TANK BioGRID BIRC3 GeneID BioGRID Affinity Capture-MS
TANK BioGRID INPP5K GeneID BioGRID Two-hybrid
TANK BioGRID ATP6V1H GeneID BioGRID Two-hybrid
TANK BioGRID RACGAP1 GeneID BioGRID Two-hybrid
TANK BioGRID AIMP2 GeneID BioGRID Two-hybrid
TANK BioGRID SDC4 GeneID BioGRID Two-hybrid
TANK BioGRID SMAD3 GeneID BioGRID Two-hybrid
TANK BioGRID LAMC1 GeneID BioGRID Two-hybrid
TANK BioGRID KPNA2 GeneID BioGRID Two-hybrid
TANK BioGRID HLA-C GeneID BioGRID Two-hybrid
TANK BioGRID FBLN1 GeneID BioGRID Two-hybrid
TANK BioGRID COPB1 GeneID BioGRID Two-hybrid
TANK BioGRID BIK GeneID BioGRID Two-hybrid
TANK BioGRID APP GeneID BioGRID Reconstituted Complex
TANK BioGRID TAB2 GeneID BioGRID Affinity Capture-Western
TANK BioGRID MAP3K14 GeneID BioGRID Affinity Capture-Western
TANK BioGRID HERC2 GeneID BioGRID Affinity Capture-MS
TANK BioGRID CBLB GeneID BioGRID Affinity Capture-Western
TANK BioGRID TICAM1 GeneID BioGRID Affinity Capture-MS
TANK BioGRID APBA3 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
TANK BioGRID MARCHF5 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TANK Protein ZC3H12A GeneID HPRD
TANK Protein IKBKE GeneID HPRD
TANK Protein MAP4K5 GeneID HPRD
TANK Protein TBK1 GeneID HPRD
TANK Protein IKBKB GeneID HPRD
TANK Protein USP7 GeneID HPRD
TANK Protein TRAF3 GeneID HPRD
TANK Protein TRAF2 GeneID HPRD
TANK Protein TRAF1 GeneID HPRD
TANK Protein CHUK GeneID HPRD
TANK Protein IKBKG GeneID HPRD
TANK BioGRID IRF7 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TANK BioGRID IRF3 GeneID BioGRID Affinity Capture-Western
TANK BioGRID Tbk1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TANK BioGRID ITGB1BP1 GeneID BioGRID Affinity Capture-Western
TANK Protein IKBKG GeneID BIND IKK-gamma interacts with TANK.
TANK Protein IKBKE GeneID BIND IKK-epsilon interacts with TANK.
TANK Protein CHUK GeneID BIND IKK-alpha interacts with TANK.
TANK Protein CHUK GeneID BIND TANK interacts with IKK-alpha.
StringDB
A B experiments database textmining combined score hadb nhadb
TANK MIB2 0 0 165 165 1 1
TANK USP4 0 0 259 276 1 1
TANK KPNA2 131 0 74 163 1 1
TANK LTA 0 900 96 905 1 1
TANK IFNL3 0 0 203 203 1 1
TANK TNIP2 279 0 202 400 1 1
TANK CSNK1A1 192 0 0 192 1 1
TANK PTPN11 0 900 150 913 1 1
TANK TIFA 0 0 445 445 1 1
TANK SIGIRR 0 0 141 276 1 1
TANK DTX4 0 0 325 332 1 1
TANK TNIP1 192 0 225 347 1 1
TANK IRAK3 0 0 283 294 1 1
TANK TICAM1 409 600 704 923 1 2
TANK NFKBIE 0 0 206 206 1 1
TANK SOCS3 0 0 217 223 1 1
TANK ZNF598 192 0 0 192 1 1
TANK RIPK2 0 0 285 344 1 2
TANK TNFRSF8 0 0 353 353 1 1
TANK UEVLD 192 0 0 221 1 1
TANK TNFRSF13C 0 0 284 284 1 1
TANK IFNGR1 0 0 134 186 1 1
TANK BAIAP2L1 128 0 81 164 1 1
TANK BTRC 0 0 150 193 1 1
TANK EIF3K 192 0 0 192 1 1
TANK CD8A 0 0 233 232 1 1
TANK ZFP36 270 0 92 308 1 1
TANK TNFSF10 0 0 180 179 1 2
TANK TLR2 0 0 391 404 1 2
TANK LRRK2 0 0 73 190 1 2
TANK TOLLIP 0 0 242 241 1 1
TANK SH2D3C 0 0 183 201 1 1
TANK TRAF3 870 900 989 999 1 2
TANK TRIM38 0 0 390 390 1 1
TANK BECN1 0 0 139 209 1 2
TANK HLA-DPA1 0 0 60 158 1 1
TANK OTUD7B 192 0 180 314 1 1
TANK IL2 0 0 162 161 1 1
TANK TLR6 0 0 289 288 1 1
TANK CASP1 0 0 359 367 1 2
TANK SHARPIN 0 0 177 177 1 1
TANK JUN 0 0 325 325 1 2
TANK NOD1 0 0 259 258 1 2
TANK TRIM11 0 0 162 190 1 1
TANK TMEM173 0 0 468 468 1 1
TANK TFG 0 0 684 684 1 1
TANK CARD11 0 0 306 306 1 1
TANK HLA-DRA 0 0 0 189 1 1
TANK TYK2 0 0 249 261 1 1
TANK TRIM17 0 0 143 196 1 1
TANK CD86 0 0 166 167 1 1
TANK KRT80 192 0 0 192 1 1
TANK ENSG00000173366 0 0 467 473 1 1
TANK PLEKHB2 192 0 0 192 1 1
TANK TBKBP1 0 800 868 972 1 1
TANK TNFRSF21 0 0 155 154 1 1
TANK MUL1 270 0 108 321 1 2
TANK ATF2 0 0 211 228 1 1
TANK CRP 0 0 0 188 1 2
TANK PGLYRP1 0 0 47 155 1 1
TANK PTGS2 0 0 136 155 1 2
TANK UBE2V1 0 0 294 294 1 1
TANK MARCH9 0 0 202 226 1 1
TANK BCL3 0 0 188 188 1 1
TANK REL 0 0 325 332 1 2
TANK NLRP3 0 0 310 309 1 2
TANK HSP90AA1 0 0 165 165 1 2
TANK TRIM56 0 0 241 240 1 1
TANK EDA2R 0 0 306 306 1 1
TANK RNF5 0 0 167 186 1 1
TANK SQSTM1 0 800 205 834 1 2
TANK BNIP3 0 0 138 179 1 2
TANK TIPARP 0 0 81 178 1 1
TANK TNFSF13B 0 0 170 169 1 1
TANK CD40 270 0 854 888 1 2
TANK PPM1B 0 0 172 203 1 1
TANK NLRX1 0 0 342 342 1 2
TANK ACTB 0 0 233 232 1 2
TANK ATG12 0 0 163 163 1 2
TANK UBE2N 0 0 310 309 1 1
TANK HNRNPM 157 0 0 156 1 1
TANK WDR41 0 0 175 175 1 1
TANK TLR5 0 0 310 309 1 1
TANK CHUK 457 0 607 799 1 1
TANK UBE2L3 0 0 270 270 1 1
TANK RPS27A 0 900 87 907 1 1
TANK IFNAR2 0 0 240 239 1 1
TANK GSK3B 128 0 53 153 1 2
TANK UNC93B1 0 0 324 323 1 1
TANK RALB 0 0 487 487 1 2
TANK LTBR 0 0 450 450 1 1
TANK OCA2 0 0 216 216 1 1
TANK RIPK1 0 900 768 979 1 2
TANK MAP4K5 213 0 0 213 1 1
TANK TRIM68 0 0 162 161 1 1
TANK ECSIT 0 0 282 282 1 1
TANK CIITA 0 0 74 157 1 1
TANK NOD2 0 0 286 286 1 2
TANK ADSS 128 0 66 150 1 1
TANK BCL10 0 0 193 243 1 1
TANK MLKL 0 0 112 186 1 2
TANK ADAL 0 0 112 252 1 1
TANK MAVS 0 600 951 980 1 2
TANK OTUD5 0 0 499 511 1 1
TANK TRAT1 0 0 287 286 1 1
TANK ALK 0 0 258 271 1 2
TANK TRAIP 0 0 643 643 1 1
TANK ACTG1 192 0 68 214 1 1
TANK TRADD 0 900 886 988 1 1
TANK CCL20 0 0 156 174 1 1
TANK IL10 0 0 235 235 1 2
TANK PFDN5 128 0 144 247 1 1
TANK IRAK4 0 0 459 472 1 1
TANK RNF31 0 0 241 240 1 1
TANK TRIM21 0 0 190 190 1 1
TANK OTUB2 0 0 247 248 1 1
TANK UBXN1 0 0 210 210 1 1
TANK MB21D1 0 0 499 499 1 1
TANK TRIM26 0 0 152 151 1 1
TANK MARCH11 0 0 97 193 1 1
TANK DDX41 0 0 294 294 1 1
TANK DDX58 0 600 755 898 1 1
TANK AIM2 0 0 331 331 1 2
TANK CCL3 0 0 134 159 1 1
TANK SMAD3 131 0 63 150 1 2
TANK MAP3K3 0 0 166 189 1 1
TANK ZC3H12A 650 0 973 990 1 1
TANK BIRC3 270 0 306 483 1 1
TANK SYK 0 0 195 208 1 2
TANK UBE2M 0 0 57 155 1 1
TANK NFKBIA 0 0 463 474 1 2
TANK AIMP2 111 0 0 204 1 1
TANK EP300 0 0 143 152 1 2
TANK TNFRSF9 0 0 239 239 1 1
TANK CCDC138 192 0 0 192 1 1
TANK IL4 0 0 163 163 1 1
TANK UBA52 0 900 0 900 1 1
TANK TRAFD1 0 0 261 261 1 1
TANK MOXD1 192 0 0 192 1 1
TANK IRF4 0 0 161 161 1 1
TANK TNFAIP8L2 0 0 171 172 1 1
TANK PLP2 0 0 205 343 1 1
TANK NEK7 0 0 0 245 1 1
TANK CSNK1D 192 0 0 192 1 1
TANK NAA50 128 0 0 171 1 1
TANK TRAF7 0 0 232 244 1 1
TANK OTULIN 0 0 95 195 1 1
TANK CASP5 0 0 140 175 1 1
TANK CCL2 0 0 187 187 1 2
TANK TELO2 192 0 0 192 1 1
TANK GTF2E2 0 0 95 172 1 1
TANK CASP8 0 0 296 312 1 2
TANK PREP 192 0 0 192 1 1
TANK APBA3 157 0 73 185 1 1
TANK CALCOCO2 0 0 323 323 1 2
TANK ATG5 0 0 160 182 1 2
TANK SH2D3A 0 0 294 294 1 1
TANK EDAR 0 0 270 270 1 1
TANK TRIP6 192 0 0 192 1 1
TANK TLR8 0 0 391 391 1 1
TANK STAT2 0 0 342 342 1 1
TANK PCBP2 0 0 182 181 1 1
TANK IRF1 0 0 309 309 1 2
TANK FUBP3 192 0 0 192 1 1
TANK TRIM5 0 0 165 165 1 1
TANK PBXIP1 270 0 0 270 1 1
TANK SMCR8 0 800 439 883 1 1
TANK SIKE1 0 650 370 770 1 1
TANK KRT9 129 0 70 155 1 1
TANK PELI1 128 0 240 398 1 1
TANK IL10RB 0 0 109 170 1 1
TANK TRAF6 270 600 857 963 1 2
TANK MAP3K5 0 0 147 183 1 1
TANK OPTN 0 800 468 889 1 2
TANK IL18BP 0 0 155 154 1 1
TANK DHX36 0 0 180 201 1 1
TANK TLR7 0 0 582 591 1 2
TANK IRF5 0 0 334 334 1 1
TANK IFNB1 0 0 670 672 1 1
TANK PPP1CA 0 0 166 172 1 1
TANK LYN 0 0 150 249 1 1
TANK LCA5 0 0 122 156 1 1
TANK EIF4G2 192 0 0 192 1 1
TANK TENM3 192 0 0 192 1 1
TANK MARCH4 0 0 232 252 1 1
TANK MAP4K4 0 900 44 901 1 1
TANK IKBKG 876 800 988 999 1 1
TANK HABP2 192 0 0 192 1 1
TANK TBP 0 0 0 158 1 1
TANK PSMD14 0 0 138 158 1 1
TANK MAPK8 0 0 161 161 1 2
TANK AMOT 192 0 0 192 1 1
TANK TDP2 0 0 144 198 1 1
TANK USP18 0 0 181 191 1 1
TANK TIFAB 0 0 181 181 1 1
TANK CISH 0 0 170 169 1 1
TANK GUCD1 0 0 243 242 1 1
TANK OTUB1 0 0 251 266 1 1
TANK UBC 0 900 76 903 1 2
TANK SASS6 192 0 0 192 1 1
TANK ISG15 0 0 374 374 1 2
TANK SPHK1 0 0 388 388 1 2
TANK VEZF1 0 0 56 245 1 1
TANK IFIH1 0 600 716 884 1 1
TANK NFKBIB 0 0 260 276 1 1
TANK RBCK1 0 0 229 228 1 1
TANK DHX58 0 0 505 505 1 1
TANK MAP3K8 0 0 216 216 1 1
TANK TLR1 0 0 390 403 1 1
TANK SOCS1 0 0 290 290 1 1
TANK RNF41 192 0 384 492 1 1
TANK BTK 0 0 150 164 1 1
TANK RB1CC1 0 0 139 171 1 2
TANK MARCH7 0 0 138 271 1 1
TANK PRPF38B 0 0 113 194 1 1
TANK IRF7 270 600 650 900 1 1
TANK NFKB2 0 0 342 356 1 1
TANK CASP10 0 0 185 204 1 1
TANK TNFAIP3 192 0 324 442 1 2
TANK TAX1BP1 0 0 376 389 1 2
TANK MAP3K14 270 900 141 932 1 1
TANK SEC16A 0 0 149 188 1 2
TANK IFNAR1 0 0 390 390 1 1
TANK BCL2A1 0 0 117 151 1 1
TANK IFI16 0 0 323 323 1 1
TANK NKIRAS2 0 0 135 153 1 1
TANK C9orf72 270 0 161 375 1 2
TANK SRSF11 186 0 0 186 1 1
TANK RELB 0 0 340 340 1 2
TANK USP10 270 0 95 311 1 1
TANK BAG4 0 900 65 902 1 1
TANK MEFV 0 0 244 243 1 1
TANK PPP1R15A 0 0 117 175 1 2
TANK TAB1 0 0 366 366 1 1
TANK DDX3X 0 0 399 422 1 1
TANK TRAF2 893 900 274 991 1 2
TANK USP14 0 0 94 249 1 2
TANK MX1 0 0 282 282 1 1
TANK ITCH 0 0 210 210 1 1
TANK MAP4K2 0 900 357 932 1 1
TANK USP15 0 0 113 183 1 1
TANK RNF135 0 600 340 724 1 1
TANK OBSL1 376 0 0 376 1 1
TANK HSPA13 128 0 0 177 1 1
TANK TAB2 270 0 414 589 1 2
TANK KIF2C 192 0 0 192 1 1
TANK TIRAP 0 0 468 468 1 1
TANK AZI2 0 800 565 913 1 1
TANK TNF 862 900 421 991 1 2
TANK SDK2 192 0 0 192 1 1
TANK ADNP 0 0 74 169 1 1
TANK RGS10 0 0 114 348 1 1
TANK UBE2D1 0 0 107 160 1 1
TANK IL1R1 0 0 322 321 1 1
TANK CBLB 270 0 74 295 1 1
TANK CASP2 0 900 66 902 1 1
TANK MYC 0 0 194 194 1 2
TANK RNF125 0 0 324 323 1 1
TANK HERC2 270 0 0 270 1 1
TANK IFNA1 0 0 505 505 1 1
TANK VPS36 0 0 0 179 1 1
TANK NR0B2 0 0 161 161 1 1
TANK IL18 0 0 282 282 1 2
TANK STAT3 0 0 206 220 1 2
TANK DEAF1 0 0 180 179 1 1
TANK RAB9A 192 0 72 247 1 2
TANK TRIM23 0 0 170 188 1 1
TANK ERN1 0 0 329 340 1 2
TANK PCSK5 192 0 0 192 1 1
TANK NF2 192 0 0 192 1 1
TANK UBB 0 900 0 900 1 1
TANK MARCH1 0 0 146 178 1 1
TANK CTLA4 0 0 137 160 1 2
TANK PSMA7 0 0 103 200 1 1
TANK TPRKB 0 0 153 153 1 1
TANK NLRC5 0 0 180 227 1 1
TANK JAK2 0 0 139 202 1 2
TANK IFI44 0 0 181 198 1 1
TANK EXOC2 0 0 434 434 1 1
TANK TLDC1 192 0 0 192 1 1
TANK RNASEL 0 0 293 304 1 1
TANK IFRD1 0 0 134 172 1 1
TANK MAP3K7 0 0 340 446 1 2
TANK NLRP4 0 0 478 478 1 1
TANK IFIT2 0 0 289 288 1 1
TANK EDARADD 0 0 120 155 1 1
TANK PLP1 0 0 67 153 1 1
TANK ZBP1 0 0 507 507 1 1
TANK CRADD 0 900 60 901 1 1
TANK NFKBIZ 0 0 205 223 1 1
TANK IRAK2 0 0 390 400 1 1
TANK NCOR2 0 0 94 150 1 1
TANK IRAK1 0 0 519 537 1 1
TANK ULK3 192 0 57 205 1 2
TANK CARD9 0 0 163 169 1 1
TANK DOK3 0 0 195 195 1 1
TANK FARSB 0 0 82 161 1 1
TANK TRAF1 874 900 943 999 1 1
TANK RNF115 192 0 0 192 1 1
TANK SARM1 0 0 362 378 1 1
TANK FADD 192 0 426 516 1 2
TANK ESX1 0 0 45 193 1 1
TANK NEDD8 0 0 73 210 1 2
TANK CFLAR 0 0 204 221 1 2
TANK MYD88 0 0 559 640 1 2
TANK HTT 274 0 73 298 1 2
TANK TP53 0 0 157 156 1 2
TANK UXT 0 0 139 178 1 1
TANK KIF5C 192 0 0 192 1 1
TANK IRF9 0 0 380 380 1 1
TANK KPNA4 0 0 107 168 1 1
TANK NAP1L1 255 0 0 254 1 1
TANK STAT1 0 0 390 390 1 2
TANK DNAJB4 128 0 57 188 1 1
TANK BNIP1 0 0 90 191 1 2
TANK TLR3 0 600 603 838 1 2
TANK TNFRSF1A 678 900 609 986 1 1
TANK NTPCR 192 0 0 192 1 1
TANK RSAD2 0 0 232 231 1 1
TANK SHKBP1 0 0 0 192 1 1
TANK NLRC3 0 0 125 187 1 1
TANK FAM126A 0 0 95 161 1 1
TANK YOD1 192 0 0 210 1 1
TANK IL6 0 0 363 363 1 2
TANK BBOX1 311 0 108 359 1 1
TANK DDX21 0 0 173 173 1 1
TANK KPNA1 0 0 125 161 1 1
TANK TRAF4 128 0 268 345 1 1
TANK SRC 0 0 193 206 1 2
TANK CD40LG 0 0 170 169 1 1
TANK HACE1 0 0 180 323 1 1
TANK TRIM4 0 0 167 167 1 1
TANK EFCAB3 0 0 140 327 1 1
TANK MYOM2 0 0 367 367 1 1
TANK TNFRSF1B 0 900 403 937 1 1
TANK IKBKE 872 800 706 997 1 1
TANK CACNA2D2 192 0 0 192 1 1
TANK USP7 213 0 127 292 1 1
TANK MLF1 192 0 0 235 1 1
TANK IFIT1 0 0 391 390 1 1
TANK RIPK3 0 0 162 214 1 2
TANK TICAM2 0 600 358 754 1 1
TANK TBK1 961 800 989 999 1 2
TANK SUMO2 270 0 76 312 1 1
TANK RNF11 0 0 202 256 1 1
TANK CXCL8 0 0 283 282 1 2
TANK NFKBID 0 0 288 288 1 1
TANK EIF2S1 0 0 117 163 1 2
TANK DHX32 0 0 103 186 1 1
TANK OAS1 0 0 180 179 1 1
TANK JAK1 0 0 242 270 1 2
TANK TRAF5 128 0 470 526 1 1
TANK TRIM27 0 0 244 243 1 1
TANK MARCH5 270 0 577 686 1 1
TANK PIAS4 0 0 173 173 1 1
TANK TBPL2 0 0 57 313 1 1
TANK IL1B 0 0 358 358 1 2
TANK CD14 0 600 0 611 1 1
TANK ENSG00000279392 0 0 270 270 1 1
TANK PGLYRP2 0 0 0 190 1 1
TANK MARCH8 0 0 173 179 1 1
TANK NLRC4 0 0 143 229 1 2
TANK IKBKB 476 0 595 788 1 2
TANK TLR4 0 600 505 793 1 2
TANK MARCH10 0 0 95 209 1 1
TANK CCDC50 192 0 0 192 1 1
TANK RIIAD1 0 0 143 291 1 1
TANK GAPDH 0 0 194 249 1 2
TANK CSF2 0 0 181 181 1 1
TANK LY96 0 600 305 712 1 1
TANK NFKB1 0 0 251 267 1 2
TANK TRAF3IP1 0 0 166 165 1 1
TANK RELA 0 0 370 370 1 2
TANK AKT1 0 0 234 246 1 2
TANK BCL2L1 0 0 170 171 1 2
TANK MARCH6 0 0 90 187 1 1
TANK CD4 0 0 218 218 1 2
TANK TMEM203 0 0 195 195 1 1
TANK IFIT3 0 0 184 183 1 1
TANK TRIM25 0 600 426 760 1 1
TANK TLR10 0 0 212 212 1 1
TANK CASP6 0 0 63 157 1 1
TANK TAB3 0 0 368 431 1 1
TANK SUMO1 270 0 232 488 1 1
TANK STAT4 0 0 67 209 1 1
TANK XPOT 0 0 0 463 1 1
TANK FAS 0 0 96 150 1 2
TANK NCS1 192 0 0 192 1 1
TANK TLR9 0 0 468 474 1 2
TANK IL4R 0 0 113 182 1 1
TANK PLK1 314 0 716 797 1 2
TANK PLEC 192 0 0 192 1 1
TANK PYCARD 0 0 160 159 1 2
TANK MAP3K1 0 900 457 943 1 1
TANK PRKRA 0 0 161 161 1 1
TANK IRF3 270 600 744 920 1 2
TANK AMOTL1 192 0 0 192 1 1
TANK BIRC2 695 0 604 880 1 1
TANK CEP63 274 0 0 274 1 1
TANK DHX9 0 0 73 166 1 1
TANK USP3 0 0 150 240 1 1
TANK CCL5 0 0 235 251 1 2
TANK CYLD 0 0 553 563 1 1
TANK UBE2D3 0 0 123 176 1 1
TANK MALT1 0 0 451 451 1 1
TANK USP25 0 0 148 169 1 1
TANK CXCL10 0 0 293 307 1 2
TANK ITGB1BP1 270 0 0 270 1 1
TANK DDX56 0 0 174 173 1 1
TANK PDLIM2 0 0 287 286 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004843 Molecular Function cysteine-type deubiquitinase activity contributes_to IMP
GO:0035800 Molecular Function deubiquitinase activator activity enables IMP
GO:0046872 Molecular Function metal ion binding enables IEA
GO:0060090 Molecular Function molecular adaptor activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0031625 Molecular Function ubiquitin protein ligase binding enables IPI
GO:0006974 Biological Process DNA damage response involved_in IMP
GO:0007249 Biological Process canonical NF-kappaB signal transduction involved_in IBA
GO:0071347 Biological Process cellular response to interleukin-1 involved_in IMP
GO:0071479 Biological Process cellular response to ionizing radiation involved_in IMP
GO:0071356 Biological Process cellular response to tumor necrosis factor involved_in IMP
GO:0051607 Biological Process defense response to virus involved_in NAS
GO:0043124 Biological Process negative regulation of canonical NF-kappaB signal transduction involved_in IMP
GO:1903003 Biological Process positive regulation of protein deubiquitination involved_in IMP
GO:0032481 Biological Process positive regulation of type I interferon production involved_in IDA
GO:2000158 Biological Process positive regulation of ubiquitin-specific protease activity involved_in IMP
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0060337 Biological Process type I interferon-mediated signaling pathway involved_in NAS
GO:0005737 Cellular Component cytoplasm is_active_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0032991 Cellular Component protein-containing complex part_of IDA
GO:1902554 Cellular Component serine/threonine protein kinase complex part_of NAS
Pathways
Name DB ID
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
DDX58/IFIH1-mediated induction of interferon-alpha/beta Reactome R-HSA-168928
TICAM1-dependent activation of IRF3/IRF7 Reactome R-HSA-9013973
TRAF6 mediated IRF7 activation Reactome R-HSA-933541
Activation of IRF3, IRF7 mediated by TBK1, IKBKE Reactome R-HSA-936964
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
SARS-CoV-2 innate immunity evasion and cell-specific immune response (WP5039) WikiPathways WP5039_r124653
Interleukin-1 (IL-1) structural pathway (WP2637) WikiPathways WP2637_r117962
TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
Novel intracellular components of RIG-I-like receptor pathway (WP3865) WikiPathways WP3865_r123636
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_047441820 1 mRNA transcript variant X8 NC_000002 Reference
NM_004180 3 mRNA transcript variant 1 NC_000002 Reference
NM_133484 2 mRNA transcript variant 2 NC_000002 Reference
XM_047441804 1 mRNA transcript variant X1 NC_000002 Reference
XM_005246207 4 mRNA transcript variant X2 NC_000002 Reference
XM_047441814 1 mRNA transcript variant X7 NC_000002 Reference
XM_047441806 1 mRNA transcript variant X4 NC_000002 Reference
XM_047441812 1 mRNA transcript variant X6 NC_000002 Reference
XM_047441805 1 mRNA transcript variant X3 NC_000002 Reference
XM_047441809 1 mRNA transcript variant X5 NC_000002 Reference
NM_001199135 3 mRNA transcript variant 3 NC_000002 Reference
XM_024452335 2 mRNA transcript variant X9 NC_000002 Reference
XM_047441821 1 mRNA transcript variant X10 NC_000002 Reference