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HOTAIR

HOX transcript antisense RNA
General Information
Name HOX transcript antisense RNA
Alias
  • HOX transcript antisense RNA (non-protein coding)
  • HOXC cluster antisense RNA 4 (non-protein coding)
  • hox transcript antisense intergenic RNA
Gene_family Long non-coding RNAs with non-systematic symbols
organism Homo sapiens
entrez_id 100124700
location 12q13.13
transcript_count 17
exon_count 9
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
HOTAIR BioGRID RUNX3 GeneID BioGRID Affinity Capture-RNA
HOTAIR BioGRID MEX3B GeneID BioGRID Affinity Capture-RNA
HOTAIR BioGRID DDX5 GeneID BioGRID Affinity Capture-RNA
HOTAIR BioGRID AR GeneID BioGRID Protein-RNA
HOTAIR BioGRID EZH2 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
HOTAIR BioGRID AGO2 GeneID BioGRID Affinity Capture-RNA
HOTAIR BioGRID SNUPN GeneID BioGRID Affinity Capture-RNA
HOTAIR BioGRID DZIP3 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
HOTAIR BioGRID ATXN1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
HOTAIR BioGRID ELAVL1 GeneID BioGRID Protein-RNA
StringDB
A B experiments database textmining combined score hadb nhadb
Ontologies
ID Category Term Effect Evidence PubMed
Pathways
Name DB ID
CCL18 signaling pathway (WP5097) WikiPathways WP5097_r119075
Burn wound healing (WP5055) WikiPathways WP5055_r122621
lncRNA-mediated mechanisms of therapeutic resistance (WP3672) WikiPathways WP3672_r123394
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_186242 1 ncRNA transcript variant 9 NC_000012 Reference
NR_186245 1 ncRNA transcript variant 12 NC_000012 Reference
NR_186247 1 ncRNA transcript variant 14 NC_000012 Reference
NR_186244 1 ncRNA transcript variant 11 NC_000012 Reference
NR_186243 1 ncRNA transcript variant 10 NC_000012 Reference
NR_186249 1 ncRNA transcript variant 16 NC_000012 Reference
NR_186250 1 ncRNA transcript variant 17 NC_000012 Reference
NR_186248 1 ncRNA transcript variant 15 NC_000012 Reference
NR_047517 2 ncRNA transcript variant 1 NC_000012 Reference
NR_186241 1 ncRNA transcript variant 8 NC_000012 Reference
NR_186246 1 ncRNA transcript variant 13 NC_000012 Reference
NR_186240 1 ncRNA transcript variant 7 NC_000012 Reference
NR_047518 2 ncRNA transcript variant 3 NC_000012 Reference
NR_186239 1 ncRNA transcript variant 6 NC_000012 Reference
NR_186237 1 ncRNA transcript variant 4 NC_000012 Reference
NR_003716 4 ncRNA transcript variant 2 NC_000012 Reference
NR_186238 1 ncRNA transcript variant 5 NC_000012 Reference