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OPTN

optineurin
General Information
Name optineurin
Alias
  • optineurin
  • E3-14.7K-interacting protein
  • FIP-2
  • HIP-7
  • Huntingtin interacting protein L
  • huntingtin yeast partner L
  • huntingtin-interacting protein 7
  • huntingtin-interacting protein L
  • nemo-related protein
  • optic neuropathy-inducing protein
  • transcription factor IIIA-interacting protein
  • transcrption factor IIIA-interacting protein
  • tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
Gene_family
organism Homo sapiens
entrez_id 10133
location 10p13
transcript_count 4
exon_count 16
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Stringdb Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and [...]
    nextProt Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
OPTN BioGRID TRIM21 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID ORF1ab GeneID BioGRID Biochemical Activity
OPTN BioGRID CSNK2A3 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID TBK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-localization; Proximity Label-MS; Reconstituted Complex; Two-hybrid
OPTN BioGRID PRKAA2 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID PRKAA1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID CSNK2A2 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID CSNK2A1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID TNIP1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Two-hybrid
OPTN BioGRID YWHAH GeneID BioGRID Affinity Capture-MS
OPTN BioGRID YWHAG GeneID BioGRID Affinity Capture-MS
OPTN BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
OPTN BioGRID TOM1 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID MYO6 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
OPTN BioGRID USP5 GeneID BioGRID Co-fractionation
OPTN BioGRID HSPA4 GeneID BioGRID Co-fractionation
OPTN BioGRID HTT GeneID BioGRID Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex; Two-hybrid
OPTN BioGRID PPP1R7 GeneID BioGRID Co-fractionation
OPTN BioGRID WWP2 GeneID BioGRID Biochemical Activity; Reconstituted Complex
OPTN BioGRID JAK3 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID JAK2 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID DYNLL2 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID DYNLL1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID LGALS9 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID ELAC2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CAND1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID WDR12 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ARFGAP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID BRIX1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ADI1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MOB1A GeneID BioGRID Proximity Label-MS
OPTN BioGRID DARS2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTPAP GeneID BioGRID Proximity Label-MS
OPTN BioGRID RETSAT GeneID BioGRID Proximity Label-MS
OPTN BioGRID ANKHD1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NLE1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID KDM3B GeneID BioGRID Proximity Label-MS
OPTN BioGRID ATP6V1H GeneID BioGRID Proximity Label-MS
OPTN BioGRID LARS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MRPS17 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPL26L1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID UBXN1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID EXOSC3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID COQ6 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CFAP20 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MRPL22 GeneID BioGRID Proximity Label-MS
OPTN BioGRID UBE2S GeneID BioGRID Proximity Label-MS
OPTN BioGRID CACYBP GeneID BioGRID Proximity Label-MS
OPTN BioGRID RSL1D1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTHFD1L GeneID BioGRID Proximity Label-MS
OPTN BioGRID DCAF13 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ARIH1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTCH2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SLC39A14 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TARDBP GeneID BioGRID Proximity Label-MS
OPTN BioGRID LARS2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID UFL1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID LARP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SYNE2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PALLD GeneID BioGRID Proximity Label-MS
OPTN BioGRID KLHDC10 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PDCD11 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SEC31A GeneID BioGRID Proximity Label-MS
OPTN BioGRID COPG1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PARK7 GeneID BioGRID Proximity Label-MS
OPTN BioGRID XPOT GeneID BioGRID Proximity Label-MS
OPTN BioGRID CDC37 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HNRNPUL1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ILVBL GeneID BioGRID Proximity Label-MS
OPTN BioGRID AFG3L2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SUGT1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NUP50 GeneID BioGRID Proximity Label-MS
OPTN BioGRID EBP GeneID BioGRID Proximity Label-MS
OPTN BioGRID ATP5F1EP2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TIPRL GeneID BioGRID Proximity Label-MS
OPTN BioGRID BRAT1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID OSBPL8 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RDH13 GeneID BioGRID Proximity Label-MS
OPTN BioGRID H2AZ2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MARS2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID LYRM7 GeneID BioGRID Proximity Label-MS
OPTN BioGRID DCUN1D5 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ITCH GeneID BioGRID Proximity Label-MS
OPTN BioGRID DDX59 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RAB1B GeneID BioGRID Proximity Label-MS
OPTN BioGRID COL18A1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NAA40 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NPEPL1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID QTRT2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID GGCT GeneID BioGRID Proximity Label-MS
OPTN BioGRID EPS8L2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TBC1D15 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS; Two-hybrid
OPTN BioGRID PAIP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PRPF8 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NOP56 GeneID BioGRID Proximity Label-MS
OPTN BioGRID EIF3M GeneID BioGRID Proximity Label-MS
OPTN BioGRID MYL9 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TUBA1B GeneID BioGRID Proximity Label-MS
OPTN BioGRID SF3B4 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CALCOCO2 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
OPTN BioGRID DDX39A GeneID BioGRID Proximity Label-MS
OPTN BioGRID OPTN GeneID BioGRID Affinity Capture-Western; FRET; Proximity Label-MS; Reconstituted Complex; Two-hybrid
OPTN BioGRID SCAMP3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID DLGAP5 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CROCC GeneID BioGRID Proximity Label-MS
OPTN BioGRID SEC24C GeneID BioGRID Proximity Label-MS
OPTN BioGRID KIF23 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ROCK2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RAB9A GeneID BioGRID Proximity Label-MS
OPTN BioGRID TRIP13 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NEMF GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTMR6 GeneID BioGRID Proximity Label-MS
OPTN BioGRID USP10 GeneID BioGRID Proximity Label-MS
OPTN BioGRID AP3D1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TAX1BP1 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
OPTN BioGRID FUBP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS; Reconstituted Complex
OPTN BioGRID YARS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID AGPS GeneID BioGRID Proximity Label-MS
OPTN BioGRID NAA10 GeneID BioGRID Proximity Label-MS
OPTN BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SHOC2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NCOA4 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RAB7A GeneID BioGRID Proximity Label-MS
OPTN BioGRID XRCC5 GeneID BioGRID Proximity Label-MS
OPTN BioGRID WARS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID UQCRC2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SURF6 GeneID BioGRID Proximity Label-MS
OPTN BioGRID STAT3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SRP9 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SNRNP70 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SDC4 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SDC2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID S100A11 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPS27A GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPS25 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPLP0 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPL27 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPL19 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPL12 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RPA1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RP9 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RECQL GeneID BioGRID Proximity Label-MS
OPTN BioGRID RARS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RAN GeneID BioGRID Proximity Label-MS
OPTN BioGRID RAC1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID QARS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PSMB4 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MAP2K1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PRKCI GeneID BioGRID Proximity Label-MS
OPTN BioGRID PPP2R5D GeneID BioGRID Proximity Label-MS
OPTN BioGRID POLR2C GeneID BioGRID Proximity Label-MS
OPTN BioGRID POLD2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PIK3C3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SERPINB6 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PCBP2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID OAT GeneID BioGRID Proximity Label-MS
OPTN BioGRID PNP GeneID BioGRID Proximity Label-MS
OPTN BioGRID NFE2L2 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID NDUFV1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NCL GeneID BioGRID Proximity Label-MS
OPTN BioGRID MYL6 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MYL1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MYH9 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MKI67 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MIF GeneID BioGRID Proximity Label-MS
OPTN BioGRID MAGEA1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SMAD2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NBR1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CAPRIN1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID LDHA GeneID BioGRID Proximity Label-MS
OPTN BioGRID KPNA4 GeneID BioGRID Proximity Label-MS
OPTN BioGRID IARS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HSPE1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HSPD1 GeneID BioGRID Co-localization; Proximity Label-MS
OPTN BioGRID HNRNPH2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HMGN2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HEXA GeneID BioGRID Proximity Label-MS
OPTN BioGRID HADHA GeneID BioGRID Proximity Label-MS
OPTN BioGRID H1-2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID GSR GeneID BioGRID Proximity Label-MS
OPTN BioGRID GNAI3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID GNAI2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID GLO1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID GCLM GeneID BioGRID Proximity Label-MS
OPTN BioGRID GFPT1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID GCDH GeneID BioGRID Proximity Label-MS
OPTN BioGRID XRCC6 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ELAVL1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID EIF5A GeneID BioGRID Proximity Label-MS
OPTN BioGRID EIF4A2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID EEF1B2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID DNM2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID DYNC1H1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CSTF1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CSNK1D GeneID BioGRID Proximity Label-MS
OPTN BioGRID CDKN2A GeneID BioGRID Proximity Label-MS
OPTN BioGRID CDK7 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CDK2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CDK1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CBS GeneID BioGRID Proximity Label-MS
OPTN BioGRID CAD GeneID BioGRID Proximity Label-MS
OPTN BioGRID ATP5F1A GeneID BioGRID Proximity Label-MS
OPTN BioGRID ASS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ARL2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ACTG1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ACLY GeneID BioGRID Proximity Label-MS
OPTN BioGRID ACACA GeneID BioGRID Proximity Label-MS
OPTN BioGRID AARS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID gtf3a.L GeneID BioGRID Reconstituted Complex
OPTN BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
OPTN BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
OPTN BioGRID STX12 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID SMCHD1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID TTLL12 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID TOMM40 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
OPTN BioGRID NDRG1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID ZMPSTE24 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID RBM12 GeneID BioGRID Affinity Capture-MS; Two-hybrid
OPTN BioGRID AIMP1 GeneID BioGRID Affinity Capture-MS; Two-hybrid
OPTN BioGRID ZMYM6 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID UBA3 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID RAP1B GeneID BioGRID Affinity Capture-MS
OPTN BioGRID RAB3IL1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID PTGFRN GeneID BioGRID Affinity Capture-MS
OPTN BioGRID NARS1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID MPI GeneID BioGRID Affinity Capture-MS
OPTN BioGRID LETM1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID EPHX1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID EPB41 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID ATP2B4 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID RHOA GeneID BioGRID Affinity Capture-MS
OPTN BioGRID SFXN1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID WDR20 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID MAVS GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
OPTN BioGRID THUMPD1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID WIPI1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID UBC GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
OPTN BioGRID ATG9A GeneID BioGRID Affinity Capture-Western; Co-localization
OPTN BioGRID MAILR GeneID BioGRID Affinity Capture-RNA; Co-fractionation; Protein-RNA
OPTN BioGRID MAP1LC3B GeneID BioGRID Affinity Capture-Western; Co-crystal Structure; Co-localization; Protein-peptide; Reconstituted Complex
OPTN BioGRID SOD1 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID DCAF4 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID NEB GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID MYH3 GeneID BioGRID Two-hybrid
OPTN BioGRID FTH1 GeneID BioGRID Two-hybrid
OPTN BioGRID CLTC GeneID BioGRID Two-hybrid
OPTN BioGRID DST GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID ZNF181 GeneID BioGRID Two-hybrid
OPTN BioGRID CMYA5 GeneID BioGRID Two-hybrid
OPTN BioGRID KANSL1L GeneID BioGRID Two-hybrid
OPTN BioGRID ZNF426 GeneID BioGRID Two-hybrid
OPTN BioGRID SNX6 GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID ZNF302 GeneID BioGRID Two-hybrid
OPTN BioGRID DZIP1 GeneID BioGRID Two-hybrid
OPTN BioGRID AKAP6 GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID DYSF GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID SLMAP GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID ZNF711 GeneID BioGRID Two-hybrid
OPTN BioGRID VWF GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID VCP GeneID BioGRID Proximity Label-MS; Two-hybrid
OPTN BioGRID UBB GeneID BioGRID Proximity Label-MS; Two-hybrid
OPTN BioGRID TTN GeneID BioGRID Co-localization; Two-hybrid
OPTN BioGRID WIPI2 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS; Reconstituted Complex
OPTN BioGRID GIGYF2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID BCL2L13 GeneID BioGRID Proximity Label-MS
OPTN BioGRID GABARAPL1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Reconstituted Complex; Two-hybrid
OPTN BioGRID KHNYN GeneID BioGRID Proximity Label-MS
OPTN BioGRID ATG2A GeneID BioGRID Proximity Label-MS
OPTN BioGRID ATG14 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID GABARAPL2 GeneID BioGRID Proximity Label-MS; Reconstituted Complex
OPTN BioGRID GABARAP GeneID BioGRID Affinity Capture-Western; Proximity Label-MS; Reconstituted Complex
OPTN BioGRID FAF1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID IMMT GeneID BioGRID Proximity Label-MS
OPTN BioGRID SEC24A GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTX2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID PGRMC2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID DNM1L GeneID BioGRID Proximity Label-MS
OPTN BioGRID SCO2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HNRNPDL GeneID BioGRID Proximity Label-MS
OPTN BioGRID UBAP2L GeneID BioGRID Proximity Label-MS
OPTN BioGRID TOMM70 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ARMCX2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID RB1CC1 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID KEAP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TOMM20 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTMR4 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SNX3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ULK1 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID STAM GeneID BioGRID Proximity Label-MS
OPTN BioGRID UGDH GeneID BioGRID Proximity Label-MS
OPTN BioGRID THOP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MAP3K7 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SGTA GeneID BioGRID Proximity Label-MS
OPTN BioGRID RAD23B GeneID BioGRID Proximity Label-MS
OPTN BioGRID RAB5B GeneID BioGRID Proximity Label-MS
OPTN BioGRID PPM1G GeneID BioGRID Proximity Label-MS
OPTN BioGRID PFAS GeneID BioGRID Proximity Label-MS
OPTN BioGRID PRKN GeneID BioGRID Affinity Capture-Western; Co-localization; Proximity Label-MS
OPTN BioGRID PAK2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID OPA1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NDUFB10 GeneID BioGRID Proximity Label-MS
OPTN BioGRID NDUFA8 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTX1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HK2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID HDGF GeneID BioGRID Proximity Label-MS
OPTN BioGRID HCCS GeneID BioGRID Proximity Label-MS
OPTN BioGRID GPD2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CHCHD2P9 GeneID BioGRID Proximity Label-MS
OPTN BioGRID VPS37A GeneID BioGRID Proximity Label-MS
OPTN BioGRID SLC25A46 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ARMC10 GeneID BioGRID Proximity Label-MS
OPTN BioGRID DOCK8 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MYO19 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TBC1D17 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS; Reconstituted Complex; Two-hybrid
OPTN BioGRID COA7 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MTARC1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MFF GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
OPTN BioGRID SAR1A GeneID BioGRID Proximity Label-MS
OPTN BioGRID CISD1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID SYNJ2BP GeneID BioGRID Proximity Label-MS
OPTN BioGRID RMDN3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ATG2B GeneID BioGRID Proximity Label-MS
OPTN BioGRID RNF31 GeneID BioGRID Proximity Label-MS
OPTN BioGRID OCIAD1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CHCHD3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID TMED9 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MARCHF5 GeneID BioGRID Proximity Label-MS
OPTN BioGRID DHX29 GeneID BioGRID Proximity Label-MS
OPTN BioGRID MIEF1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CYCS GeneID BioGRID Proximity Label-MS
OPTN BioGRID ZFYVE1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID CDK5RAP1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID ARMCX3 GeneID BioGRID Proximity Label-MS
OPTN BioGRID FIS1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID UBQLN1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID FUS GeneID BioGRID Proximity Label-MS
OPTN BioGRID EWSR1 GeneID BioGRID Proximity Label-MS
OPTN BioGRID EPS15 GeneID BioGRID Proximity Label-MS; Two-hybrid
OPTN BioGRID DHFR GeneID BioGRID Proximity Label-MS
OPTN BioGRID CPT1A GeneID BioGRID Proximity Label-MS
OPTN BioGRID CDC34 GeneID BioGRID Proximity Label-MS
OPTN BioGRID BCKDHB GeneID BioGRID Proximity Label-MS
OPTN BioGRID AK2 GeneID BioGRID Proximity Label-MS
OPTN BioGRID POU6F2 GeneID BioGRID Two-hybrid
OPTN BioGRID HSF2BP GeneID BioGRID Two-hybrid
OPTN BioGRID DAZAP2 GeneID BioGRID Two-hybrid
OPTN BioGRID PICK1 GeneID BioGRID Two-hybrid
OPTN BioGRID USP2 GeneID BioGRID Two-hybrid
OPTN BioGRID ZNF17 GeneID BioGRID Two-hybrid
OPTN BioGRID SDCBP GeneID BioGRID Two-hybrid
OPTN BioGRID LGALS3 GeneID BioGRID Co-localization
OPTN BioGRID LNX2 GeneID BioGRID Two-hybrid
OPTN BioGRID CCDC13 GeneID BioGRID Two-hybrid
OPTN BioGRID ZNF670 GeneID BioGRID Two-hybrid
OPTN BioGRID ARRDC3 GeneID BioGRID Two-hybrid
OPTN BioGRID RNF216 GeneID BioGRID Two-hybrid
OPTN BioGRID WASHC3 GeneID BioGRID Two-hybrid
OPTN BioGRID IKBKB GeneID BioGRID Affinity Capture-Western
OPTN BioGRID BIRC6 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID APP GeneID BioGRID Affinity Capture-Western
OPTN BioGRID SNRPD2 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID SUB1 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID RAB10 GeneID BioGRID Affinity Capture-Western; Co-localization; Two-hybrid
OPTN BioGRID TRAPPC5 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID RFFL GeneID BioGRID Biochemical Activity; Co-localization
OPTN BioGRID TNFAIP3 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID BIRC2 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID tat GeneID BioGRID Affinity Capture-MS
OPTN BioGRID HRAS GeneID BioGRID Proximity Label-MS
OPTN BioGRID LITAF GeneID BioGRID Two-hybrid
OPTN BioGRID CDC23 GeneID BioGRID Two-hybrid
OPTN BioGRID TNF GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
OPTN BioGRID PRE5 GeneID BioGRID Two-hybrid
OPTN BioGRID RRD1 GeneID BioGRID Two-hybrid
OPTN BioGRID HUA1 GeneID BioGRID Two-hybrid
OPTN BioGRID YPT1 GeneID BioGRID Two-hybrid
OPTN BioGRID Wipi2 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID Atg5 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
OPTN BioGRID ATG5 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
OPTN BioGRID IRAK1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
OPTN BioGRID TRIM16 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID RIPK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
OPTN BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
OPTN BioGRID CASP8 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID MYH6 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID CYLD GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
OPTN BioGRID NRL GeneID BioGRID Affinity Capture-Western; Co-localization
OPTN BioGRID Tbk1 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID MAP1LC3C GeneID BioGRID Two-hybrid
OPTN BioGRID ENTREP1 GeneID BioGRID Two-hybrid
OPTN BioGRID HSPB1 GeneID BioGRID Two-hybrid
OPTN BioGRID ATG8 GeneID BioGRID Reconstituted Complex; Two-hybrid
OPTN BioGRID ZDHHC17 GeneID BioGRID Affinity Capture-Western; Two-hybrid
OPTN BioGRID ZNF329 GeneID BioGRID Two-hybrid
OPTN BioGRID ZNF398 GeneID BioGRID Two-hybrid
OPTN BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
OPTN BioGRID HACE1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
OPTN BioGRID RAB25 GeneID BioGRID Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid
OPTN BioGRID RAB11B GeneID BioGRID Affinity Capture-Western; Two-hybrid
OPTN BioGRID RAB11A GeneID BioGRID Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid
OPTN BioGRID Rab8a GeneID BioGRID Affinity Capture-Western
OPTN BioGRID Tfrc GeneID BioGRID Affinity Capture-Western
OPTN BioGRID BABAM2 GeneID BioGRID Co-fractionation
OPTN BioGRID SLF2 GeneID BioGRID Reconstituted Complex
OPTN BioGRID UQCRQ GeneID BioGRID Reconstituted Complex
OPTN BioGRID GNAS GeneID BioGRID Reconstituted Complex
OPTN BioGRID RAB12 GeneID BioGRID Affinity Capture-Western; Two-hybrid
OPTN BioGRID TFRC GeneID BioGRID Affinity Capture-Western
OPTN BioGRID RAB8A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
OPTN BioGRID RAB14 GeneID BioGRID Far Western; Two-hybrid
OPTN BioGRID PIAS4 GeneID BioGRID Two-hybrid
OPTN BioGRID RNF11 GeneID BioGRID Two-hybrid
OPTN BioGRID TNFRSF1A GeneID BioGRID Affinity Capture-Western
OPTN BioGRID TRADD GeneID BioGRID Affinity Capture-Western
OPTN BioGRID GRM1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
OPTN BioGRID TRAF3 GeneID BioGRID Affinity Capture-Western
OPTN BioGRID ZNF384 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID KCTD17 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID EIF5A2 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID PALS2 GeneID BioGRID Affinity Capture-MS
OPTN BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS
OPTN BioGRID YWHAZ GeneID BioGRID Affinity Capture-MS
OPTN BioGRID YWHAB GeneID BioGRID Affinity Capture-MS
OPTN BioGRID MPP1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
OPTN BioGRID CALM1 GeneID BioGRID Reconstituted Complex
OPTN BioGRID CDKN1A GeneID BioGRID Affinity Capture-Western; Two-hybrid
OPTN Protein TBC1D17 GeneID HPRD
OPTN Protein WASHC3 GeneID HPRD
OPTN Protein RNF11 GeneID HPRD
OPTN Protein RAB11B GeneID HPRD
OPTN Protein GTF3A GeneID HPRD
OPTN Protein FLII GeneID HPRD
OPTN Protein RAB8A GeneID HPRD
OPTN Protein FOS GeneID HPRD
OPTN Protein HTT GeneID HPRD
OPTN Protein HTT GeneID BIND FIP-2 carboxy-terminus interacts with Huntingtin in perinuclear vesicular structures.
OPTN Protein RAB8A GeneID BIND FIP-2 amino-terminus interacts with Rab8 in perinuclear vesicular structures.
StringDB
A B experiments database textmining combined score hadb nhadb
OPTN PSMC4 0 0 181 181 1 1
OPTN KLHL20 0 0 184 183 1 1
OPTN CYBB 0 0 181 181 1 2
OPTN OMA1 0 0 170 184 1 1
OPTN GRM1 270 0 381 529 1 1
OPTN ANG 0 0 520 520 1 2
OPTN LTBP3 0 0 302 302 1 1
OPTN ATG12 0 0 676 684 1 2
OPTN SLC1A1 0 0 150 203 1 1
OPTN EHD2 0 0 112 152 1 1
OPTN AFP 0 0 217 257 1 2
OPTN MYO5B 0 0 980 981 1 1
OPTN ADAT3 0 0 0 286 1 1
OPTN MICALL1 0 0 217 244 1 1
OPTN TGFBR3 0 0 202 207 1 1
OPTN SMURF1 0 0 380 390 1 1
OPTN RAB4B 0 0 63 159 1 1
OPTN CASP3 0 0 261 261 1 2
OPTN ATG4D 0 0 193 198 1 2
OPTN NLRP3 0 0 294 294 1 2
OPTN PLEKHM1 0 0 415 414 1 1
OPTN ATG101 0 0 470 484 1 2
OPTN HSPB8 0 0 246 262 1 2
OPTN A1CF 0 0 0 189 1 1
OPTN PLA2G6 0 0 167 167 1 1
OPTN PHB2 0 0 335 335 1 1
OPTN YWHAH 157 0 0 156 1 1
OPTN TXNRD2 0 0 195 195 1 1
OPTN AKAP1 131 0 66 153 1 1
OPTN CSF1 0 0 216 235 1 1
OPTN RRM2 0 0 138 161 1 1
OPTN RIPK1 835 0 531 920 1 2
OPTN AKAP10 0 0 108 163 1 1
OPTN NOD2 0 0 321 329 1 2
OPTN ADAD2 0 0 71 215 1 1
OPTN TMEM106B 0 0 413 412 1 1
OPTN ATG16L1 270 0 595 706 1 2
OPTN MT-CO2 0 0 147 177 1 1
OPTN FAM105A 0 0 81 392 1 1
OPTN KIFAP3 0 0 189 206 1 1
OPTN USF2 0 0 216 242 1 1
OPTN NTF3 0 0 112 304 1 1
OPTN PFN1 0 0 459 492 1 1
OPTN NPLOC4 0 0 159 230 1 1
OPTN DLAT 0 0 66 227 1 1
OPTN KIF1C 0 0 0 189 1 1
OPTN CUL3 0 0 183 183 1 2
OPTN CHUK 0 0 461 490 1 1
OPTN ANGPTL3 0 0 488 487 1 1
OPTN WDR41 0 0 554 655 1 1
OPTN STAM 131 0 95 193 1 1
OPTN CDKN2A 0 0 161 302 1 2
OPTN EHBP1L1 0 0 89 187 1 1
OPTN STAMBPL1 0 0 137 155 1 1
OPTN SLC11A1 0 0 90 168 1 1
OPTN HIP1R 0 0 125 156 1 1
OPTN FOXO1 0 0 142 152 1 2
OPTN KRAS 0 0 116 162 1 2
OPTN RAB39B 0 0 284 403 1 1
OPTN ADRBK1 0 0 107 268 1 1
OPTN SYNCRIP 0 0 81 155 1 1
OPTN SOD2 0 0 159 158 1 2
OPTN HSPA5 0 0 134 157 1 2
OPTN DNM1 0 0 142 165 1 1
OPTN VIPR1 0 0 142 150 1 1
OPTN HAX1 0 0 328 328 1 1
OPTN TBC1D25 0 0 270 330 1 1
OPTN LNX2 270 0 0 270 1 1
OPTN RNF34 0 0 112 153 1 1
OPTN PON1 0 0 150 184 1 1
OPTN MYO5C 0 0 162 181 1 1
OPTN TNIP1 744 0 445 874 1 1
OPTN TNIP2 0 0 401 412 1 1
OPTN FNDC3B 0 0 289 288 1 1
OPTN RAB11B 462 0 66 607 1 1
OPTN YWHAZ 157 0 54 168 1 1
OPTN FOS 213 0 91 338 1 2
OPTN LMAN2L 0 0 134 208 1 1
OPTN GAS7 0 0 365 376 1 1
OPTN SHARPIN 0 0 294 311 1 1
OPTN FOXC1 0 0 341 345 1 1
OPTN NOD1 0 0 204 204 1 2
OPTN SIGMAR1 0 0 490 542 1 1
OPTN CHCHD10 0 0 602 641 1 1
OPTN SEC62 0 0 150 208 1 1
OPTN TBKBP1 0 0 556 556 1 1
OPTN USP20 0 0 180 213 1 1
OPTN TLR2 0 0 183 184 1 2
OPTN CDKN2B 0 0 232 444 1 1
OPTN PEX3 0 0 193 193 1 2
OPTN TRAF3 270 0 447 579 1 2
OPTN ATXN3 0 0 282 282 1 2
OPTN TOLLIP 0 0 419 432 1 1
OPTN LRRK2 0 0 455 463 1 2
OPTN BECN1 0 0 562 583 1 2
OPTN MAPT 0 0 452 452 1 2
OPTN STOM 0 0 101 153 1 1
OPTN SNAPIN 0 0 181 181 1 1
OPTN ARF6 0 0 214 240 1 1
OPTN NRL 270 0 74 295 1 1
OPTN DNAJB6 0 0 171 171 1 1
OPTN SIKE1 0 0 141 171 1 1
OPTN CTSB 0 0 138 164 1 2
OPTN SMCR8 0 0 496 529 1 1
OPTN SIRT1 0 0 204 204 1 2
OPTN RAB22A 0 0 193 193 1 1
OPTN REPS1 0 0 140 269 1 1
OPTN UBQLN2 0 0 806 810 1 2
OPTN PPP1CA 0 0 95 161 1 1
OPTN IFNB1 0 0 335 335 1 1
OPTN ATG5 486 0 629 835 1 2
OPTN CALCOCO2 131 0 870 897 1 2
OPTN TIA1 0 0 324 329 1 1
OPTN NIPSNAP1 0 0 181 181 1 1
OPTN XBP1 0 0 202 231 1 2
OPTN TMEM263 0 0 244 243 1 1
OPTN F8A2 0 0 682 689 1 1
OPTN FUS 131 0 764 790 1 2
OPTN ATOH7 0 0 325 325 1 1
OPTN ATG10 0 0 455 455 1 2
OPTN VAMP3 0 0 306 306 1 1
OPTN USP30 0 0 503 509 1 1
OPTN TSG101 0 0 170 169 1 2
OPTN GALC 0 0 141 233 1 1
OPTN ARL13B 0 0 460 469 1 1
OPTN PXDNL 0 0 0 400 1 1
OPTN CALCRL 0 0 0 208 1 1
OPTN AGFG1 0 0 320 319 1 1
OPTN UBC 978 0 141 981 1 2
OPTN RIN3 0 0 344 374 1 1
OPTN EHBP1 0 0 122 170 1 1
OPTN MAP1LC3B 974 0 881 998 1 2
OPTN RAB11FIP3 0 0 413 471 1 1
OPTN NR2E3 0 0 57 227 1 1
OPTN ULK1 131 0 525 569 1 2
OPTN TIAL1 0 0 150 183 1 1
OPTN IKBKG 270 0 771 469 1 1
OPTN HNRNPDL 131 0 134 215 1 1
OPTN M6PR 0 0 215 215 1 1
OPTN PON2 0 0 162 220 1 1
OPTN CTSD 0 0 284 284 1 2
OPTN TOMM70A 131 0 210 302 1 1
OPTN VTI1B 0 0 134 267 1 2
OPTN ZNF469 0 0 162 161 1 1
OPTN NTF4 0 0 468 723 1 1
OPTN TRIM32 0 0 170 169 1 1
OPTN STX12 195 0 0 195 1 1
OPTN HLA-A 0 0 194 194 1 1
OPTN TRAT1 0 0 286 286 1 1
OPTN OTUD5 0 0 180 231 1 1
OPTN ATG7 0 0 566 650 1 2
OPTN TRMT1L 0 0 91 184 1 1
OPTN FOSL2 0 0 66 184 1 1
OPTN MICALL2 0 0 181 181 1 1
OPTN GRK6 0 0 0 189 1 1
OPTN GFAP 0 0 182 182 1 2
OPTN MATR3 0 0 595 705 1 1
OPTN IL10 0 0 150 181 1 2
OPTN VEGFA 0 0 158 157 1 2
OPTN TNFRSF11A 0 0 341 356 1 1
OPTN GABARAP 415 800 743 968 1 2
OPTN PTEN 0 0 252 252 1 2
OPTN DNM1L 131 0 401 459 1 2
OPTN WIPI1 0 0 529 541 1 2
OPTN RHBDL2 0 0 0 206 1 1
OPTN KIAA0226 0 0 247 246 1 1
OPTN PKD2L1 0 0 413 412 1 1
OPTN AMBRA1 0 0 510 520 1 2
OPTN PPP1R9A 0 0 242 241 1 1
OPTN NFKBIA 0 0 268 280 1 2
OPTN GLE1 0 0 244 243 1 1
OPTN MYRIP 0 0 181 198 1 1
OPTN CNTN2 0 0 651 651 1 1
OPTN MARK2 0 0 150 235 1 1
OPTN GOLGA6A 0 0 310 309 1 1
OPTN SIX6 0 0 422 422 1 1
OPTN GOPC 0 0 146 206 1 2
OPTN FAM134B 0 0 394 404 1 1
OPTN GBA 0 0 181 186 1 1
OPTN TBC1D17 672 600 883 983 1 1
OPTN TECPR1 0 0 390 391 1 1
OPTN RAB14 297 0 707 788 1 1
OPTN HPCA 0 0 60 198 1 1
OPTN RHEB 0 0 163 176 1 2
OPTN SMN2 0 0 289 289 1 1
OPTN MCM10 0 0 57 480 1 1
OPTN ENSG00000264813 0 0 294 294 1 1
OPTN THSD4 0 0 0 256 1 1
OPTN ATG2A 131 0 261 330 1 2
OPTN ADAMTS3 0 0 0 286 1 1
OPTN FAF2 0 0 134 173 1 1
OPTN INF2 0 0 71 168 1 1
OPTN PTGDS 0 0 330 345 1 1
OPTN CACYBP 0 0 72 158 1 1
OPTN UBB 146 0 90 189 1 1
OPTN RAB3IP 0 0 188 188 1 1
OPTN CAT 0 0 158 157 1 2
OPTN SPG11 0 0 601 613 1 1
OPTN LEPREL2 57 0 288 299 1 1
OPTN STBD1 0 0 414 431 1 1
OPTN EHD3 0 0 457 489 1 1
OPTN MYO6 761 0 723 931 1 1
OPTN YWHAQ 157 0 116 222 1 1
OPTN TP53INP2 0 0 135 157 1 2
OPTN IPO9 0 0 57 221 1 1
OPTN CBL 0 0 95 192 1 1
OPTN NUP62 0 0 134 153 1 1
OPTN TOM1L2 0 0 218 569 1 1
OPTN SNX9 0 0 112 248 1 1
OPTN EPG5 0 0 242 241 1 2
OPTN ACTN1 0 0 307 307 1 1
OPTN RAB11FIP4 0 0 246 273 1 1
OPTN ZNF569 0 0 203 203 1 1
OPTN HNRNPA3 0 0 150 203 1 1
OPTN AIMP1 283 0 0 282 1 1
OPTN LOXL1 0 0 391 390 1 1
OPTN TNFAIP3 192 0 185 432 1 2
OPTN ATG4B 0 0 391 408 1 2
OPTN NFKB2 0 0 193 235 1 1
OPTN IFNAR1 0 0 139 158 1 1
OPTN RNF166 0 0 243 242 1 1
OPTN AZIN1 0 0 0 248 1 1
OPTN TFRC 835 0 454 906 1 1
OPTN RNFT2 0 0 0 207 1 1
OPTN RUFY4 0 0 157 175 1 1
OPTN SNCG 0 0 180 205 1 1
OPTN FNBP1L 0 0 137 157 1 1
OPTN GPNMB 0 0 108 169 1 1
OPTN DRAM1 0 0 261 277 1 2
OPTN RELB 0 0 174 224 1 2
OPTN RAB7A 131 0 503 561 1 2
OPTN ZNF670 408 0 0 408 1 1
OPTN ATF3 0 0 67 158 1 2
OPTN G3BP1 0 0 283 282 1 1
OPTN RAB1B 131 0 140 334 1 2
OPTN UBXN6 0 0 106 192 1 1
OPTN RHBDL1 0 0 0 173 1 1
OPTN RAB3GAP1 0 0 229 273 1 1
OPTN ANKRD27 0 0 108 278 1 1
OPTN CCPG1 0 0 269 269 1 1
OPTN WDR45 0 0 193 243 1 2
OPTN BTK 0 0 0 158 1 1
OPTN RAB39A 0 0 48 207 1 1
OPTN RAB23 0 0 144 231 1 2
OPTN C1orf116 0 0 70 171 1 1
OPTN RNF41 0 0 193 193 1 1
OPTN SOCS1 0 0 61 206 1 1
OPTN UVRAG 0 0 416 416 1 2
OPTN APOL1 0 0 159 158 1 2
OPTN WDFY3 63 0 556 567 1 2
OPTN IGF1 0 0 161 161 1 2
OPTN IRF7 0 0 213 213 1 1
OPTN NHLRC1 0 0 74 171 1 1
OPTN NUP205 0 0 321 321 1 1
OPTN SIX1 0 0 309 309 1 1
OPTN NBR1 0 0 806 855 1 2
OPTN TANK 0 800 468 889 1 2
OPTN TNF 486 0 340 653 1 2
OPTN SNAP25 0 0 142 151 1 1
OPTN TECPR2 0 0 184 190 1 2
OPTN UNC13A 0 0 375 379 1 1
OPTN BDNF 0 0 264 310 1 2
OPTN ADAMTS4 0 0 0 214 1 1
OPTN VAPB 0 0 681 744 1 1
OPTN PNPLA6 0 0 204 215 1 1
OPTN PON3 0 0 181 213 1 1
OPTN WIPI2 415 0 505 703 1 2
OPTN CLSTN1 0 0 42 208 1 1
OPTN ATP13A2 0 0 287 286 1 1
OPTN FIS1 131 0 455 511 1 2
OPTN COL8A2 0 0 137 165 1 1
OPTN POU2F1 0 0 263 263 1 1
OPTN ITCH 0 0 100 150 1 1
OPTN RBM8A 0 0 181 181 1 1
OPTN UBE3A 0 0 136 158 1 1
OPTN WDR20 211 0 463 558 1 1
OPTN SETX 0 0 636 714 1 1
OPTN AKT1 0 0 280 291 1 2
OPTN GIPC1 0 0 471 567 1 1
OPTN ATF4 0 0 123 158 1 2
OPTN RRM1 0 0 162 161 1 1
OPTN CD4 0 0 189 189 1 2
OPTN SEPHS2 0 0 0 188 1 1
OPTN ALS2 0 0 681 702 1 1
OPTN SRBD1 0 0 505 506 1 1
OPTN IKBKB 270 0 484 639 1 2
OPTN GSTM1 0 0 150 165 1 1
OPTN ENSG00000279392 0 0 162 161 1 1
OPTN ATF6 0 0 175 187 1 2
OPTN NTRK2 0 0 147 212 1 1
OPTN NIPA1 0 0 276 321 1 1
OPTN MTMR4 131 0 118 200 1 1
OPTN PARL 0 0 556 556 1 1
OPTN DLG1 0 0 193 193 1 1
OPTN VMP1 0 0 255 254 1 2
OPTN RNF216 117 0 126 196 1 1
OPTN CST3 0 0 154 153 1 1
OPTN ARF4 0 0 103 152 1 1
OPTN USP3 0 0 45 368 1 1
OPTN EFEMP1 0 0 138 191 1 1
OPTN GRM5 0 0 450 450 1 1
OPTN UBQLN1 131 0 361 657 1 1
OPTN PINK1 0 0 921 926 1 2
OPTN EHD1 0 0 447 570 1 1
OPTN PHF20 0 0 215 215 1 1
OPTN RTN4 0 0 94 150 1 1
OPTN CYLD 486 0 870 931 1 1
OPTN PIKFYVE 0 0 171 238 1 2
OPTN PDLIM2 0 0 140 219 1 1
OPTN PKD2 0 0 716 716 1 2
OPTN KRR1 0 0 68 170 1 1
OPTN TLR9 0 0 161 161 1 2
OPTN GRK5 0 0 0 189 1 1
OPTN ARHGEF12 0 0 136 154 1 1
OPTN GBAS 0 0 167 181 1 1
OPTN DENR 0 0 210 210 1 1
OPTN IRF3 0 0 597 598 1 2
OPTN NGF 0 0 170 221 1 2
OPTN FOXF2 0 0 0 215 1 1
OPTN WDR81 0 0 141 191 1 1
OPTN FOXO3 0 0 184 183 1 2
OPTN NEXN 0 0 384 384 1 1
OPTN NEK1 0 0 456 470 1 1
OPTN ATXN2 0 0 654 717 1 1
OPTN APOE 0 0 693 700 1 2
OPTN KIF5B 0 0 117 175 1 1
OPTN YWHAB 157 0 0 156 1 1
OPTN RAB11FIP2 0 0 607 667 1 1
OPTN USP2 76 0 181 423 1 1
OPTN EEA1 0 0 325 336 1 2
OPTN DENND5A 0 0 266 266 1 1
OPTN ATG4C 0 0 167 167 1 2
OPTN USP8 0 0 283 282 1 1
OPTN CDC42 0 0 155 184 1 2
OPTN RAB25 653 0 731 904 1 2
OPTN ADAMTS17 0 0 47 223 1 1
OPTN SIAH3 0 0 113 162 1 1
OPTN SRC 0 0 166 179 1 2
OPTN DAO 0 0 253 327 1 2
OPTN PSMB5 0 0 134 157 1 1
OPTN ATG3 0 0 519 558 1 2
OPTN DNAJB1 0 0 164 163 1 2
OPTN LGALS3 273 0 252 432 1 2
OPTN TESC 0 0 66 203 1 1
OPTN DIXDC1 0 0 0 189 1 1
OPTN TLR3 0 0 240 239 1 2
OPTN RABGEF1 0 0 174 213 1 1
OPTN BIRC6 270 0 148 371 1 1
OPTN RTN3 63 0 202 230 1 1
OPTN EWSR1 131 0 291 357 1 1
OPTN WWP2 0 0 0 195 1 1
OPTN EIF2AK3 0 0 162 161 1 2
OPTN GIPC2 0 0 0 216 1 1
OPTN TBK1 978 800 989 999 1 2
OPTN ATG2B 131 0 161 239 1 2
OPTN RGS19 0 0 299 391 1 2
OPTN NRBF2 0 0 188 188 1 2
OPTN RRAGA 0 0 125 186 1 1
OPTN EIF2S1 0 0 203 203 1 2
OPTN STX17 0 0 459 470 1 2
OPTN RAB11A 821 0 988 998 1 2
OPTN TOMM20 131 0 460 521 1 2
OPTN RAC2 0 0 66 178 1 1
OPTN MARCH5 131 0 270 338 1 1
OPTN TRIM50 0 0 180 181 1 1
OPTN VDAC1 0 0 393 406 1 2
OPTN GORASP1 0 0 137 155 1 1
OPTN TSC2 0 0 151 150 1 2
OPTN HACE1 270 0 397 617 1 1
OPTN RAB7B 0 0 501 501 1 1
OPTN ABCD3 0 0 177 177 1 1
OPTN VAMP7 0 0 261 261 1 2
OPTN BNIP3L 0 0 652 672 1 2
OPTN NARFL 0 0 0 188 1 1
OPTN ZNF384 157 0 0 156 1 1
OPTN TGOLN2 0 0 202 202 1 1
OPTN HAP1 0 0 250 265 1 1
OPTN USP7 0 0 69 311 1 1
OPTN ZFYVE1 131 0 561 613 1 2
OPTN RIPK3 0 0 340 367 1 2
OPTN BNIP3 0 0 556 563 1 2
OPTN SQSTM1 415 0 953 978 1 2
OPTN GLI3 0 0 181 181 1 1
OPTN LRP12 0 0 181 181 1 1
OPTN MAPK3 0 0 95 151 1 2
OPTN KEAP1 131 0 263 332 1 2
OPTN STUB1 0 0 181 181 1 2
OPTN CTTN 0 0 324 323 1 1
OPTN GBP7 0 0 137 155 1 1
OPTN SPG7 0 0 142 165 1 1
OPTN CAV2 0 0 394 431 1 1
OPTN NEFH 0 0 451 476 1 1
OPTN ACTB 0 0 243 242 1 2
OPTN INS 0 0 218 218 1 2
OPTN ATG13 0 0 517 531 1 2
OPTN COX4I1 0 0 210 210 1 1
OPTN MUL1 0 0 413 412 1 2
OPTN PSEN1 0 0 298 298 1 2
OPTN KIF13A 0 0 120 220 1 1
OPTN RFFL 270 0 0 282 1 1
OPTN ACTN3 0 0 415 414 1 1
OPTN HSP90AA1 0 0 181 181 1 2
OPTN KIF5A 0 0 233 250 1 1
OPTN DPP6 0 0 219 236 1 1
OPTN TFEB 0 0 459 491 1 2
OPTN VPS16 0 0 151 150 1 1
OPTN GABARAPL1 415 800 653 957 1 2
OPTN GIGYF2 131 0 134 215 1 1
OPTN SEMA4B 0 0 0 158 1 1
OPTN SYTL1 0 0 113 180 1 1
OPTN RAB35 0 0 234 234 1 1
OPTN USP6 0 0 161 167 1 1
OPTN PMCH 0 0 128 168 1 1
OPTN MLKL 0 0 265 277 1 2
OPTN SEMA4A 0 0 60 198 1 1
OPTN RAB1A 0 0 834 834 1 1
OPTN RAB11FIP1 0 0 450 450 1 1
OPTN LTBP2 0 0 394 407 1 1
OPTN UBE2N 0 0 246 245 1 1
OPTN TARDBP 0 0 705 735 1 2
OPTN LRRC59 0 0 66 160 1 1
OPTN TOMM40 131 0 143 223 1 1
OPTN RHOA 0 0 122 178 1 2
OPTN UBE2L3 0 0 162 161 1 1
OPTN HSPA8 0 0 302 302 1 2
OPTN ATG9A 0 0 487 519 1 2
OPTN GTF3A 213 0 412 522 1 1
OPTN ZFYVE20 0 0 181 181 1 1
OPTN CDKN1A 270 0 66 301 1 2
OPTN ZNF746 0 0 284 284 1 1
OPTN RAB24 0 0 209 209 1 2
OPTN TRIM3 0 0 120 211 1 1
OPTN RIPK2 0 0 193 205 1 2
OPTN TFAM 0 0 180 184 1 2
OPTN TREM2 0 0 264 264 1 1
OPTN MFN1 0 0 466 469 1 2
OPTN RAP2C 0 0 0 202 1 1
OPTN RAB27A 0 0 260 260 1 1
OPTN RING1 0 0 136 190 1 1
OPTN OLFM3 0 0 520 520 1 1
OPTN UCHL1 0 0 160 286 1 2
OPTN CD8A 0 0 164 163 1 1
OPTN FUNDC1 0 0 666 684 1 2
OPTN MNT 0 0 56 223 1 1
OPTN NCOA4 0 0 250 325 1 2
OPTN ARIH1 0 0 290 334 1 1
OPTN SOD1 270 0 746 823 1 2
OPTN LTA 0 0 0 189 1 1
OPTN USP4 0 0 57 252 1 1
OPTN MIB2 0 0 181 236 1 1
OPTN DCSTAMP 0 0 324 323 1 1
OPTN GRN 0 0 506 506 1 1
OPTN GOLGA2 0 0 259 258 1 1
OPTN ELP3 0 0 292 306 1 1
OPTN VCP 146 0 749 906 1 2
OPTN RBM12 391 0 0 390 1 1
OPTN NEIL1 0 0 0 215 1 1
OPTN NME4 0 0 157 156 1 1
OPTN LAMP2 0 0 325 367 1 2
OPTN NARF 0 0 70 323 1 1
OPTN PXDN 0 0 91 630 1 1
OPTN JUN 0 0 161 224 1 2
OPTN TEX264 0 0 134 187 1 1
OPTN RHOT1 0 0 344 354 1 1
OPTN DAPK1 0 0 134 157 1 2
OPTN TMEM173 0 0 194 194 1 1
OPTN TNIP3 0 0 310 325 1 1
OPTN ZNF629 0 0 208 208 1 1
OPTN HNRNPA1 0 0 505 535 1 1
OPTN SEPHS1 0 0 66 279 1 1
OPTN AMFR 0 0 193 363 1 1
OPTN ENSG00000173366 0 0 158 157 1 1
OPTN CAV1 0 0 324 393 1 2
OPTN ERBB4 0 0 162 193 1 1
OPTN KIF1B 0 0 124 277 1 1
OPTN AIF1 0 0 181 181 1 2
OPTN USP35 0 0 281 355 1 1
OPTN UTP6 0 0 0 190 1 1
OPTN ULK2 0 0 335 335 1 2
OPTN CWF19L1 0 0 108 184 1 1
OPTN HPCAL1 0 0 0 181 1 1
OPTN MVP 0 0 137 155 1 1
OPTN SNAP29 0 0 290 305 1 2
OPTN ERICH3 0 0 90 181 1 1
OPTN SNCA 0 0 469 469 1 2
OPTN GIPC3 0 0 47 184 1 1
OPTN CASP1 0 0 243 242 1 2
OPTN TMTC2 0 0 130 159 1 1
OPTN INA 0 0 142 195 1 1
OPTN GORASP2 0 0 205 205 1 1
OPTN RAB8B 0 600 320 724 1 2
OPTN OCLM 0 0 537 537 1 1
OPTN TMEM59 0 0 167 254 1 1
OPTN SH3GLB1 0 0 193 193 1 2
OPTN CD59 0 0 48 169 1 1
OPTN ATG4A 0 0 261 278 1 2
OPTN TBC1D15 484 0 391 679 1 1
OPTN SLC1A2 0 0 233 232 1 1
OPTN TRAF6 0 0 392 392 1 2
OPTN CYCS 131 0 241 317 1 2
OPTN EXOC6 0 0 180 179 1 1
OPTN WDR36 0 0 831 868 1 1
OPTN IMMT 131 0 181 257 1 1
OPTN RPTOR 0 0 187 187 1 2
OPTN DAB2 0 0 406 507 1 1
OPTN TBC1D5 0 0 241 247 1 2
OPTN FBXO7 0 0 218 218 1 1
OPTN RBM47 0 0 0 302 1 1
OPTN MIEF1 131 0 235 306 1 1
OPTN HSPA4 0 0 217 217 1 1
OPTN CYP1B1 0 0 606 614 1 1
OPTN TRIM5 0 0 217 217 1 1
OPTN ASB10 0 0 611 632 1 1
OPTN HNRNPA2B1 0 0 403 440 1 1
OPTN PRNP 0 0 191 191 1 2
OPTN IFIH1 0 0 235 241 1 1
OPTN SESN2 0 0 150 168 1 2
OPTN HBZ 0 0 182 187 1 1
OPTN SPATA2 0 0 123 167 1 1
OPTN PAK2 131 0 0 150 1 1
OPTN RAB38 0 0 242 243 1 1
OPTN LTBP1 0 0 57 160 1 1
OPTN RAB6A 0 0 250 250 1 1
OPTN PEX5 0 0 241 343 1 1
OPTN MAPK8 0 0 144 159 1 2
OPTN SEC61G 0 0 54 213 1 1
OPTN VPS35 0 0 303 303 1 2
OPTN BCL2L13 131 0 518 572 1 2
OPTN TRIM21 0 0 180 266 1 1
OPTN ZNF763 0 0 207 207 1 1
OPTN EPM2A 0 0 435 435 1 2
OPTN MB21D1 0 0 294 294 1 1
OPTN RAB32 0 0 242 241 1 2
OPTN C21orf2 0 0 329 403 1 1
OPTN UBXN1 131 0 62 150 1 1
OPTN ADAMTS10 0 0 235 408 1 1
OPTN RAP2B 0 0 46 155 1 1
OPTN ADAMTSL4 0 0 0 256 1 1
OPTN YWHAG 157 0 0 156 1 1
OPTN NEFL 0 0 233 268 1 1
OPTN RAB3GAP2 0 0 108 181 1 1
OPTN DDX58 0 0 322 340 1 1
OPTN EIF5A2 157 0 0 156 1 1
OPTN MAVS 131 0 323 407 1 2
OPTN MAP1B 0 0 107 152 1 2
OPTN MAP1LC3C 192 0 717 768 1 2
OPTN SPAST 0 0 236 244 1 1
OPTN POLG 0 0 120 153 1 1
OPTN PAX6 0 0 173 173 1 1
OPTN TRADD 270 0 181 376 1 1
OPTN DCTN1 0 0 602 611 1 1
OPTN ABCA1 0 0 181 181 1 2
OPTN MYOC 0 0 856 880 1 1
OPTN MIEF2 0 0 296 296 1 1
OPTN TBCE 0 0 139 172 1 1
OPTN VPS54 0 0 204 204 1 1
OPTN LGALS4 0 0 210 225 1 1
OPTN RNF31 131 0 471 520 1 1
OPTN ATG16L2 0 0 183 196 1 2
OPTN RABEP1 0 0 165 165 1 1
OPTN ZNF436 0 0 206 206 1 1
OPTN RAP2A 0 0 45 205 1 1
OPTN FLOT1 0 0 430 430 1 1
OPTN HOOK1 0 0 87 225 1 1
OPTN SNPH 0 0 170 190 1 1
OPTN HERPUD1 0 0 414 414 1 1
OPTN ADAMTS6 0 0 0 183 1 1
OPTN KCTD17 157 0 0 156 1 1
OPTN OTULIN 0 0 289 730 1 1
OPTN CASP8 270 0 453 583 1 2
OPTN KIF16B 0 0 137 371 1 1
OPTN ALB 0 0 287 362 1 2
OPTN CDC23 294 0 0 294 1 1
OPTN PCMTD1 0 0 141 158 1 1
OPTN SEC23B 0 0 50 210 1 2
OPTN SNCAIP 0 0 211 224 1 2
OPTN ZMIZ1 0 0 73 167 1 1
OPTN GOLGA4 0 0 398 398 1 1
OPTN MADD 0 0 325 325 1 1
OPTN CNTF 0 0 157 156 1 1
OPTN LGALS8 0 0 606 615 1 1
OPTN UBQLN3 0 0 247 284 1 1
OPTN MARK3 0 0 0 201 1 1
OPTN SS18L1 0 0 255 256 1 1
OPTN AUP1 0 0 210 225 1 1
OPTN ZNF687 0 0 283 282 1 1
OPTN AGR2 0 0 391 391 1 1
OPTN VAMP8 0 0 264 264 1 2
OPTN MKNK1 72 0 0 233 1 1
OPTN HDAC6 0 0 372 432 1 2
OPTN ARSB 0 0 60 206 1 2
OPTN EIF2AK4 0 0 161 161 1 2
OPTN CD300C 0 0 853 853 1 1
OPTN RHBDL3 0 0 0 215 1 1
OPTN GDNF 0 0 155 213 1 2
OPTN ERN1 0 0 222 264 1 2
OPTN TRIM23 0 0 134 191 1 1
OPTN RAB8A 872 600 989 999 1 2
OPTN MYH6 270 0 578 678 1 1
OPTN PLEKHG5 0 0 181 181 1 1
OPTN MCOLN1 0 0 129 183 1 2
OPTN RASSF3 0 0 195 195 1 1
OPTN LAMP1 0 0 395 423 1 2
OPTN CHCHD2 0 0 181 210 1 1
OPTN ESX1 0 0 218 231 1 1
OPTN FADD 0 0 141 159 1 2
OPTN RAB4A 0 0 341 356 1 1
OPTN HTT 877 0 988 998 1 2
OPTN MYD88 0 0 181 198 1 2
OPTN EGFR 0 0 143 193 1 2
OPTN KIF5C 0 0 90 190 1 1
OPTN ZNF17 165 0 0 165 1 1
OPTN TUBA4A 0 0 465 477 1 1
OPTN TRIM16 130 0 181 257 1 2
OPTN MPP6 157 0 0 156 1 1
OPTN TP53 0 0 260 260 1 2
OPTN STX5 0 0 142 211 1 1
OPTN EPS15 329 0 448 614 1 1
OPTN GMDS 0 0 320 319 1 1
OPTN CFTR 0 0 181 181 1 2
OPTN ZNF44 0 0 206 206 1 1
OPTN ADAT2 0 0 0 284 1 1
OPTN MAP3K7 131 0 122 216 1 2
OPTN RAB10 494 0 484 728 1 1
OPTN PABPC1 0 0 167 167 1 1
OPTN MAP1A 0 0 456 516 1 2
OPTN PITX2 0 0 236 264 1 1
OPTN RAB3IL1 311 0 52 347 1 1
OPTN IRAK1 270 0 763 822 1 1
OPTN LMX1B 0 0 329 329 1 1
OPTN MOB3B 0 0 158 157 1 1
OPTN RMDN3 131 0 243 315 1 1
OPTN TIMM23 0 0 210 210 1 1
OPTN PARK7 0 0 370 370 1 2
OPTN EFNA5 0 0 435 435 1 1
OPTN FLII 213 0 0 213 1 1
OPTN UBD 0 0 510 510 1 1
OPTN ACTA1 0 0 183 183 1 1
OPTN MLPH 0 0 288 288 1 1
OPTN ZNF501 0 0 207 207 1 1
OPTN TAX1BP1 270 0 922 947 1 2
OPTN FHDC1 0 0 90 330 1 1
OPTN GOLPH3 0 0 228 227 1 1
OPTN C9orf72 0 0 840 859 1 2
OPTN UBA1 0 0 128 222 1 1
OPTN TRAK2 0 0 103 209 1 1
OPTN RBCK1 0 0 256 287 1 1
OPTN SYNJ1 0 0 170 169 1 1
OPTN BRCA1 0 0 289 301 1 2
OPTN PPIF 0 0 150 173 1 1
OPTN OPA1 131 0 212 285 1 2
OPTN DOLK 0 0 69 477 1 1
OPTN MFF 131 0 325 397 1 1
OPTN MICAL1 0 0 150 282 1 1
OPTN MAP2K5 0 0 81 175 1 1
OPTN RB1CC1 131 0 567 613 1 2
OPTN CALCOCO1 0 0 86 289 1 1
OPTN NFE2L2 0 0 210 270 1 2
OPTN PGAM5 0 0 364 364 1 1
OPTN GDAP1 44 0 132 169 1 1
OPTN UBE2K 0 0 119 156 1 1
OPTN AZI2 0 0 520 520 1 1
OPTN TAB2 0 0 282 282 1 2
OPTN KIF21B 0 0 54 198 1 1
OPTN PPARGC1A 0 0 234 234 1 2
OPTN SLC1A3 0 0 155 181 1 1
OPTN IRGM 62 0 391 404 1 2
OPTN RNF125 0 0 122 159 1 1
OPTN MYC 0 0 213 213 1 2
OPTN GNS 0 0 60 206 1 1
OPTN RAB11FIP5 0 0 560 596 1 1
OPTN IL18 0 0 210 210 1 2
OPTN PARK2 389 0 743 847 1 1
OPTN TMCO1 0 0 601 610 1 1
OPTN VAPA 0 0 167 363 1 1
OPTN CCDC3 0 0 260 423 1 1
OPTN IL2RA 0 0 181 181 1 1
OPTN CACNG6 0 0 0 208 1 1
OPTN TRAF2 0 0 197 197 1 2
OPTN APPL1 0 0 141 300 1 1
OPTN ANGPTL7 0 0 63 164 1 1
OPTN NPC1 0 0 155 154 1 2
OPTN ARHGEF28 0 0 242 257 1 1
OPTN USP15 0 0 320 356 1 1
OPTN SAMD5 0 0 66 157 1 1
OPTN TOMM7 0 0 220 220 1 1
OPTN FYCO1 0 0 391 531 1 2
OPTN BCL2L1 0 0 205 205 1 2
OPTN RAB33B 0 0 151 150 1 2
OPTN RELA 0 0 187 187 1 2
OPTN TRIM25 0 0 119 272 1 1
OPTN EVI5 0 0 139 173 1 1
OPTN PIK3R4 0 0 455 455 1 2
OPTN FHL5 0 0 161 161 1 1
OPTN TOM1 0 0 491 553 1 1
OPTN XPOT 0 0 218 235 1 1
OPTN GRK4 0 0 54 320 1 1
OPTN TAB3 0 0 166 165 1 1
OPTN ITPR2 0 0 156 194 1 1
OPTN CENPV 0 0 153 205 1 1
OPTN GABARAPL2 415 800 870 984 1 2
OPTN FKBP8 0 0 282 282 1 1
OPTN GPS1 0 0 50 265 1 1
OPTN TRAK1 0 0 140 212 1 1
OPTN KIF1A 0 0 150 281 1 1
OPTN KLHL26 0 0 124 178 1 1
OPTN TLR4 0 0 294 294 1 2
OPTN GAPDH 0 0 294 299 1 2
OPTN ELOVL5 0 0 204 262 1 1
OPTN PHYH 0 0 0 260 1 1
OPTN ATG14 131 0 517 573 1 2
OPTN BIRC2 192 0 194 347 1 1
OPTN GZMM 0 0 246 246 1 1
OPTN UBQLN4 0 0 211 425 1 1
OPTN CREB1 0 0 159 158 1 2
OPTN LONP1 0 0 150 193 1 1
OPTN TAF15 0 0 272 281 1 1
OPTN FIG4 0 0 604 613 1 1
OPTN LRSAM1 0 0 557 570 1 2
OPTN RYR2 0 0 308 307 1 1
OPTN PSAP 0 0 171 201 1 1
OPTN RBM45 0 0 171 202 1 1
OPTN PLK1 0 900 170 914 1 2
OPTN SIAH1 0 0 124 198 1 1
OPTN MYT1L 0 0 72 204 1 1
OPTN ZDHHC17 270 0 215 440 1 1
OPTN INPPL1 0 0 42 187 1 1
OPTN MAP1LC3B2 0 0 87 571 1 1
OPTN REP15 0 0 204 204 1 1
OPTN ODF3L2 42 0 108 174 1 1
OPTN HSPD1 273 0 108 323 1 1
OPTN CTNND1 0 0 55 201 1 1
OPTN TRPC1 0 0 309 309 1 1
OPTN NRG2 0 0 358 358 1 1
OPTN MYO5A 0 0 292 292 1 1
OPTN MTOR 0 0 394 394 1 2
OPTN CISD1 131 0 115 198 1 1
OPTN MTMR3 0 0 155 154 1 2
OPTN OLFM2 0 0 252 268 1 1
OPTN ANXA11 0 0 103 247 1 1
OPTN SEC24D 0 0 153 209 1 1
OPTN PSEN2 0 0 228 227 1 1
OPTN MARK4 0 0 49 196 1 1
OPTN CCDC53 679 0 0 679 1 1
OPTN OPA3 0 0 279 279 1 1
OPTN MPP1 157 0 0 156 1 1
OPTN STAT1 0 0 388 388 1 2
OPTN PLEK 0 0 160 159 1 1
OPTN ACTN4 0 0 305 305 1 1
OPTN CCNF 0 0 373 400 1 1
OPTN TNFRSF1A 270 0 234 416 1 1
OPTN PIK3C3 0 0 556 556 1 2
OPTN SMN1 0 0 264 264 1 1
OPTN CHMP2B 0 0 683 731 1 2
OPTN PPP1R12A 0 0 474 494 1 1
OPTN RAB12 270 0 645 734 1 2
OPTN IL6 0 0 234 234 1 2
OPTN PIRT 0 0 141 159 1 1
OPTN RNF11 64 0 258 335 1 1
OPTN ATXN1 0 0 150 166 1 1
OPTN NEDD4 0 0 171 200 1 2
OPTN TRIM27 0 0 117 157 1 1
OPTN SIRT5 0 0 124 188 1 1
OPTN BAG3 0 0 294 321 1 2
OPTN IL1B 0 0 284 284 1 2
OPTN RAB5A 0 0 577 577 1 2
OPTN SNX18 0 0 181 203 1 1
OPTN KIF3B 0 0 164 170 1 1
OPTN RHO 0 0 124 158 1 2
OPTN FGGY 0 0 261 277 1 1
OPTN RNFT1 0 0 150 297 1 1
OPTN IKBKE 0 0 113 250 1 1
OPTN PEX13 0 0 169 202 1 1
OPTN HRAS 169 0 125 253 1 2
OPTN MAP1LC3A 486 0 576 828 1 2
OPTN OPTC 0 0 325 339 1 1
OPTN AFAP1 0 0 324 323 1 1
OPTN LMTK2 0 0 452 508 1 1
OPTN APP 270 0 319 481 1 2
OPTN MFN2 0 0 470 484 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0070530 Molecular Function K63-linked polyubiquitin modification-dependent protein binding enables IBA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0046872 Molecular Function metal ion binding enables IEA
GO:0031593 Molecular Function polyubiquitin modification-dependent protein binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IPI
GO:0007030 Biological Process Golgi organization involved_in IMP
GO:0090161 Biological Process Golgi ribbon formation involved_in IBA
GO:0090161 Biological Process Golgi ribbon formation involved_in IDA
GO:0090161 Biological Process Golgi ribbon formation involved_in IMP
GO:0043001 Biological Process Golgi to plasma membrane protein transport involved_in IMP
GO:0006914 Biological Process autophagy involved_in IEA
GO:0008219 Biological Process cell death involved_in TAS
GO:0034620 Biological Process cellular response to unfolded protein involved_in IMP
GO:0050829 Biological Process defense response to Gram-negative bacterium involved_in IMP
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0043124 Biological Process negative regulation of canonical NF-kappaB signal transduction involved_in IEA
GO:0001920 Biological Process negative regulation of receptor recycling involved_in IMP
GO:0061734 Biological Process parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization involved_in IMP
GO:0010508 Biological Process positive regulation of autophagy involved_in IDA
GO:1904417 Biological Process positive regulation of xenophagy involved_in IMP
GO:0034067 Biological Process protein localization to Golgi apparatus involved_in IBA
GO:0034067 Biological Process protein localization to Golgi apparatus involved_in IMP
GO:0043122 Biological Process regulation of canonical NF-kappaB signal transduction involved_in IBA
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0005794 Cellular Component Golgi apparatus is_active_in IBA
GO:0005794 Cellular Component Golgi apparatus located_in IDA
GO:0000139 Cellular Component Golgi membrane located_in TAS
GO:0005776 Cellular Component autophagosome located_in IEA
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0048471 Cellular Component perinuclear region of cytoplasm located_in IEA
GO:0055038 Cellular Component recycling endosome membrane located_in TAS
GO:0005802 Cellular Component trans-Golgi network located_in IDA
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Cell Cycle Reactome R-HSA-1640170
Membrane Trafficking Reactome R-HSA-199991
Regulation of PLK1 Activity at G2/M Transition Reactome R-HSA-2565942
Mitotic G2-G2/M phases Reactome R-HSA-453274
TNFR1-induced proapoptotic signaling Reactome R-HSA-5357786
Regulation of TNFR1 signaling Reactome R-HSA-5357905
TNFR1-induced NF-kappa-B signaling pathway Reactome R-HSA-5357956
Vesicle-mediated transport Reactome R-HSA-5653656
G2/M Transition Reactome R-HSA-69275
Cell Cycle, Mitotic Reactome R-HSA-69278
Death Receptor Signaling Reactome R-HSA-73887
TNF signaling Reactome R-HSA-75893
TBC/RABGAPs Reactome R-HSA-8854214
Rab regulation of trafficking Reactome R-HSA-9007101
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001008211 1 mRNA transcript variant 1 NC_000010 Reference
NM_001008213 1 mRNA transcript variant 4 NC_000010 Reference
NM_021980 4 mRNA transcript variant 2 NC_000010 Reference
NM_001008212 2 mRNA transcript variant 3 NC_000010 Reference