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NOD1

nucleotide binding oligomerization domain containing 1
General Information
Name nucleotide binding oligomerization domain containing 1
Alias
  • nucleotide-binding oligomerization domain-containing protein 1
  • NLR family, CARD domain containing 1
  • caspase recruitment domain family, member 4
  • caspase recruitment domain-containing protein 4
  • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1
Gene_family NLR family|Caspase recruitment domain containing
organism Homo sapiens
entrez_id 10392
location 7p14.3
transcript_count 35
exon_count 20
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
    Stringdb Nucleotide-binding oligomerization domain-containing protein 1; Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Sh [...]
    nextProt Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses (PubMed:19043560, PubMed:22672233, PubMed:27099311). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the receptor interacting protein-2/RIPK2. RIPK2 subsequently recruits the kinase TAK1 to activate NF-kappa-B and MAPK signaling pathways (PubMed:10880512). Regulates also antiviral response elicited by dsRNA and the expression of RLR pathway members by targeting IFIH1 and TRAF3 to modulate the formation of IFIH1-MAVS and TRAF3-MAVS complexes leading to increased transcription of type I IFNs (PubMed:32169843). Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process (PubMed:33942347). In addition, plays a role in insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, NOD1 and RIPK2 localize to insulin vesicles where they recruit RAB1A to direct insulin trafficking through the cytoplasm (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
NOD1 BioGRID SREBF1 GeneID BioGRID Negative Genetic
NOD1 BioGRID RIPK2 GeneID BioGRID Affinity Capture-Western; FRET; Reconstituted Complex
NOD1 BioGRID IRGM GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID UBC GeneID BioGRID Co-crystal Structure; Reconstituted Complex
NOD1 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NOD1 BioGRID NOD1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NOD1 BioGRID NOD2 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID SHMT2 GeneID BioGRID Affinity Capture-RNA
NOD1 BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
NOD1 BioGRID RNF34 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NOD1 BioGRID PSMA7 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID SUGT1 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID SOX8 GeneID BioGRID Two-hybrid
NOD1 BioGRID GABRB1 GeneID BioGRID Two-hybrid
NOD1 BioGRID TRAF4 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID XIAP GeneID BioGRID Reconstituted Complex
NOD1 BioGRID COPS6 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID GPS1 GeneID BioGRID Affinity Capture-Western
NOD1 Protein CARD6 GeneID HPRD
NOD1 Protein NLRP1 GeneID HPRD
NOD1 Protein NOD1 GeneID HPRD
NOD1 Protein RIPK2 GeneID HPRD
NOD1 Protein CASP4 GeneID HPRD
NOD1 Protein CASP9 GeneID HPRD
NOD1 Protein CASP8 GeneID HPRD
NOD1 Protein CASP2 GeneID HPRD
NOD1 Protein CASP1 GeneID HPRD
NOD1 BioGRID CFLAR GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID CASP9 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID CASP8 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID CASP4 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID CASP2 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID CASP1 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID CARD6 GeneID BioGRID Affinity Capture-Western
NOD1 BioGRID NLRC4 GeneID BioGRID Affinity Capture-Western
NOD1 Protein RIPK2 GeneID BIND Nod1 interacts with, and enhances RICK activity.
NOD1 Protein NOD1 GeneID BIND Nod1 oligomerizes with other instances of Nod1.
NOD1 Protein CASP9 GeneID BIND Nod1 interacts with and regulates Caspase-9
NOD1 Protein NLRC4 GeneID BIND CARD12 (CLAN) interacts with CARD4 (Nod1).
StringDB
A B experiments database textmining combined score hadb nhadb
NOD1 MAPK8 0 0 264 264 1 2
NOD1 ARG1 0 0 154 153 1 2
NOD1 FZD7 0 0 0 157 1 1
NOD1 KCNS3 0 0 386 386 1 1
NOD1 MAP2K4 0 900 134 910 1 1
NOD1 HLA-DQA1 0 0 180 179 1 1
NOD1 IFIH1 0 0 602 636 1 1
NOD1 DIABLO 0 0 216 217 1 2
NOD1 TUFM 0 0 181 216 1 2
NOD1 SSH1 0 0 553 561 1 1
NOD1 CISH 0 0 188 251 1 1
NOD1 PRF1 0 0 166 165 1 1
NOD1 SRPK1 0 0 0 183 1 1
NOD1 CCR1 0 0 232 250 1 1
NOD1 CRHR2 0 0 74 220 1 1
NOD1 EAF1 0 0 120 438 1 1
NOD1 HNMT 0 0 329 329 1 1
NOD1 P2RX7 0 0 245 283 1 2
NOD1 FLG 0 0 137 155 1 1
NOD1 TRAPPC11 0 0 0 189 1 1
NOD1 CSK 0 0 107 158 1 1
NOD1 EAF2 0 0 0 196 1 1
NOD1 PYDC1 0 0 241 275 1 1
NOD1 CRHR1 0 0 0 188 1 1
NOD1 CX3CR1 0 0 208 208 1 1
NOD1 PGRMC1 0 0 0 318 1 1
NOD1 ALPK1 0 0 285 335 1 1
NOD1 HSPA4 0 0 167 167 1 1
NOD1 IRF2 0 0 134 329 1 1
NOD1 RPLP1 0 0 0 153 1 1
NOD1 DEFB103B 0 0 404 404 1 1
NOD1 CXCL9 0 0 225 243 1 1
NOD1 HSP90B1 0 0 125 203 1 1
NOD1 DLG5 0 0 431 462 1 1
NOD1 CCR2 0 0 286 286 1 2
NOD1 CYCS 0 0 181 211 1 2
NOD1 CXCL11 0 0 183 218 1 1
NOD1 NWD2 0 0 97 387 1 1
NOD1 MAPK9 0 0 170 169 1 2
NOD1 TLR7 0 0 618 640 1 2
NOD1 CASP9 270 600 306 783 1 2
NOD1 PYHIN1 0 0 171 183 1 1
NOD1 TRAF6 0 600 562 828 1 2
NOD1 PELI1 0 0 155 295 1 1
NOD1 BFAR 0 0 173 187 1 1
NOD1 NLRP5 0 0 394 203 1 1
NOD1 OLFM4 270 0 614 736 1 1
NOD1 IL17A 0 0 504 504 1 2
NOD1 RNF19A 0 0 68 187 1 1
NOD1 TMEM59 0 0 204 344 1 1
NOD1 PRTN3 0 0 213 213 1 1
NOD1 EGF 0 0 155 154 1 2
NOD1 IL4 0 0 396 396 1 1
NOD1 LGALS8 0 0 235 235 1 1
NOD1 PGRMC2 0 0 0 203 1 1
NOD1 SLC46A2 0 0 207 243 1 1
NOD1 BIRC3 0 900 435 942 1 1
NOD1 IL17F 0 0 243 242 1 1
NOD1 CD68 0 0 138 150 1 2
NOD1 CASP8 270 600 376 820 1 2
NOD1 ALB 0 0 218 231 1 2
NOD1 CCL2 0 0 459 473 1 2
NOD1 MTG1 0 0 55 206 1 1
NOD1 CDC37 115 0 43 269 1 1
NOD1 LRRFIP1 0 0 193 222 1 1
NOD1 CD276 0 0 218 224 1 1
NOD1 OTULIN 0 0 321 321 1 1
NOD1 GPSM1 0 0 310 309 1 1
NOD1 CARD17 0 0 151 326 1 1
NOD1 PHF11 0 0 500 499 1 1
NOD1 CASP7 0 0 174 260 1 1
NOD1 MTSS1L 0 0 0 208 1 1
NOD1 RNF31 0 0 244 280 1 1
NOD1 TRADD 0 0 299 342 1 1
NOD1 ART3 0 0 54 306 1 1
NOD1 MAVS 0 0 877 882 1 2
NOD1 IL1A 0 0 455 455 1 1
NOD1 CCL4 0 0 234 250 1 1
NOD1 GBP1 0 0 108 158 1 1
NOD1 AIM2 0 0 602 607 1 2
NOD1 DDX58 0 0 666 680 1 1
NOD1 DDX41 0 0 181 198 1 1
NOD1 AGER 0 0 195 226 1 2
NOD1 MB21D1 0 0 325 325 1 1
NOD1 TMEM201 0 0 107 197 1 1
NOD1 DEFB4B 0 0 391 390 1 1
NOD1 CDH1 0 0 203 203 1 2
NOD1 EFCAB1 0 0 98 344 1 1
NOD1 C8B 0 0 61 205 1 1
NOD1 RHOA 0 0 202 202 1 2
NOD1 BID 0 0 456 456 1 2
NOD1 IFT122 0 0 0 159 1 1
NOD1 TLR5 0 0 689 727 1 1
NOD1 CRLF2 0 0 137 165 1 1
NOD1 SLC15A1 0 0 401 402 1 1
NOD1 UBE2N 0 600 193 666 1 1
NOD1 GPR29 0 0 263 264 1 1
NOD1 BCL10 0 0 454 471 1 1
NOD1 C9orf171 0 0 157 156 1 1
NOD1 CXCR1 0 0 156 163 1 1
NOD1 NLRP9 0 0 392 201 1 1
NOD1 SART1 0 0 416 445 1 1
NOD1 NPSR1 0 0 153 152 1 1
NOD1 PTPRC 0 0 218 243 1 1
NOD1 RSPRY1 0 0 113 435 1 1
NOD1 IL22 0 0 210 210 1 1
NOD1 TAS2R38 0 0 126 157 1 1
NOD1 SLC15A2 0 0 310 353 1 1
NOD1 GABARAPL1 0 0 210 227 1 2
NOD1 RALB 0 0 101 157 1 2
NOD1 ICAM1 0 0 320 352 1 2
NOD1 DEFB124 0 0 97 256 1 1
NOD1 UNC93B1 0 0 202 256 1 1
NOD1 HSP90AA1 741 0 914 977 1 2
NOD1 LTB 0 0 114 180 1 1
NOD1 MBL2 0 0 260 260 1 1
NOD1 PTGDR2 0 0 328 328 1 1
NOD1 CRP 0 0 181 181 1 2
NOD1 RWDD4 0 0 124 185 1 1
NOD1 ACTB 0 0 341 360 1 2
NOD1 INS 0 0 244 243 1 2
NOD1 ATG13 0 0 170 260 1 2
NOD1 NLRX1 0 0 682 410 1 2
NOD1 CD40 0 0 358 372 1 2
NOD1 SELL 0 0 167 187 1 1
NOD1 EPRS 0 0 171 196 1 1
NOD1 ARL2BP 0 0 0 298 1 1
NOD1 MAPK3 0 0 245 255 1 2
NOD1 B2M 0 0 124 168 1 1
NOD1 MMP9 0 0 181 199 1 2
NOD1 FCGR2B 0 0 150 179 1 1
NOD1 BNIP3 0 0 183 200 1 2
NOD1 SQSTM1 0 0 213 213 1 2
NOD1 CCR3 0 0 352 351 1 1
NOD1 CASP1 462 600 851 973 1 2
NOD1 CXCL6 0 0 90 250 1 1
NOD1 FFAR2 0 0 317 331 1 1
NOD1 JAK3 0 0 90 154 1 1
NOD1 MAP2K3 0 900 108 909 1 1
NOD1 TNFSF10 0 0 193 210 1 2
NOD1 HLA-DRB1 0 0 306 333 1 1
NOD1 ORMDL3 0 0 142 158 1 2
NOD1 CCL24 0 0 416 431 1 1
NOD1 NLRP13 0 0 407 202 1 1
NOD1 ENSG00000173366 0 0 681 713 1 1
NOD1 MAPK12 0 650 123 697 1 1
NOD1 BCL2L11 0 0 170 227 1 2
NOD1 VPS37C 0 0 0 157 1 1
NOD1 IL10RA 0 0 181 228 1 1
NOD1 TYK2 0 0 156 180 1 1
NOD1 FZD1 0 0 0 230 1 1
NOD1 DAPK1 0 0 138 193 1 2
NOD1 TMEM173 0 0 224 252 1 1
NOD1 FUT2 0 0 144 166 1 1
NOD1 JUN 0 0 372 372 1 2
NOD1 TFF3 0 0 134 193 1 1
NOD1 TAPBP 0 0 137 169 1 1
NOD1 RHOT1 0 0 0 188 1 1
NOD1 DHX15 0 0 57 219 1 1
NOD1 LCK 0 0 117 157 1 1
NOD1 CLEC6A 0 0 392 392 1 1
NOD1 ACAP1 0 0 473 473 1 1
NOD1 IL17RA 0 0 193 193 1 1
NOD1 CCRL2 0 0 265 284 1 1
NOD1 NFKBIE 0 0 164 194 1 1
NOD1 TICAM1 0 0 377 407 1 2
NOD1 PELI3 0 0 219 299 1 1
NOD1 NLRP8 0 0 318 166 1 1
NOD1 GPATCH3 0 0 91 248 1 1
NOD1 DUSP22 0 0 0 279 1 1
NOD1 CCR5 0 0 197 197 1 1
NOD1 IL7R 0 0 124 158 1 1
NOD1 LTA 0 0 181 306 1 1
NOD1 CD69 0 0 166 182 1 1
NOD1 CD8A 0 0 408 408 1 1
NOD1 FKBP14 0 0 54 259 1 1
NOD1 KCNMB1 0 0 307 307 1 1
NOD1 BIK 0 0 135 173 1 2
NOD1 CALR 0 0 117 150 1 1
NOD1 ITGB1BP2 0 0 0 328 1 1
NOD1 ARHGEF2 0 800 901 980 1 1
NOD1 MAST3 0 0 0 164 1 1
NOD1 TBXAS1 0 0 66 169 1 1
NOD1 AZU1 0 0 89 183 1 1
NOD1 IL22RA2 0 0 122 157 1 1
NOD1 TNFSF4 0 0 229 228 1 1
NOD1 RIPK2 871 800 989 999 1 2
NOD1 HSPD1 0 0 189 210 1 1
NOD1 WASL 0 0 134 152 1 1
NOD1 CRLS1 0 0 60 313 1 1
NOD1 C5AR1 0 0 137 166 1 1
NOD1 CXCL13 0 0 233 249 1 1
NOD1 IL4R 0 0 167 220 1 1
NOD1 LRSAM1 0 0 220 237 1 2
NOD1 KCNJ11 0 0 418 418 1 1
NOD1 SLC22A4 0 0 236 255 1 1
NOD1 HCAR2 0 0 210 245 1 1
NOD1 GSDMD 0 0 181 224 1 2
NOD1 CCL5 0 0 414 426 1 2
NOD1 GAST 0 0 122 176 1 1
NOD1 GZMM 0 0 194 194 1 1
NOD1 IFNG 0 0 252 415 1 2
NOD1 BIRC2 0 900 452 944 1 1
NOD1 GAPDH 0 0 361 376 1 2
NOD1 TNFRSF25 0 0 145 182 1 1
NOD1 ATG14 0 0 182 181 1 2
NOD1 APTX 0 0 0 203 1 1
NOD1 VWA7 0 0 141 165 1 1
NOD1 TLR4 0 0 847 858 1 2
NOD1 PELI2 0 0 84 236 1 1
NOD1 MAP2K7 0 900 103 906 1 1
NOD1 NOS2 0 0 166 195 1 2
NOD1 ABL1 0 0 75 172 1 1
NOD1 GABARAPL2 0 0 212 229 1 2
NOD1 TNFSF15 0 0 181 181 1 1
NOD1 GPS1 270 0 0 285 1 1
NOD1 GGCT 0 0 108 307 1 1
NOD1 PGLYRP2 0 0 327 395 1 1
NOD1 CD83 0 0 181 218 1 1
NOD1 CD14 0 0 74 187 1 1
NOD1 STAT4 0 0 141 203 1 1
NOD1 TAB3 0 600 327 721 1 1
NOD1 CASP6 0 0 160 173 1 1
NOD1 RAN 0 0 0 153 1 2
NOD1 CLEC7A 0 0 518 518 1 1
NOD1 TLR10 0 0 460 478 1 1
NOD1 TRIM25 0 0 217 261 1 1
NOD1 PIK3R4 0 0 150 190 1 2
NOD1 CCL4L1 0 0 143 161 1 1
NOD1 BCL2L1 0 0 201 201 1 2
NOD1 RELA 0 0 269 291 1 2
NOD1 NFKB1 0 0 263 300 1 2
NOD1 CTNNB1 0 0 188 188 1 2
NOD1 MVB12B 0 0 0 155 1 1
NOD1 IKBKE 0 0 292 348 1 1
NOD1 ERAP1 0 0 139 164 1 1
NOD1 TNFRSF1B 0 0 134 191 1 1
NOD1 LACC1 0 0 210 210 1 1
NOD1 ERBB2IP 0 0 369 397 1 1
NOD1 CXCR2 0 0 225 230 1 1
NOD1 MTSS1 0 0 0 302 1 1
NOD1 IL1B 0 0 681 703 1 2
NOD1 NKX6-2 0 0 0 209 1 1
NOD1 TRAF5 0 0 495 514 1 1
NOD1 TRIM27 0 0 204 213 1 1
NOD1 OAS1 0 0 88 150 1 1
NOD1 MTPAP 0 0 0 192 1 1
NOD1 CXCL8 0 0 631 646 1 2
NOD1 MAPK13 0 650 113 687 1 1
NOD1 IL6 0 0 608 612 1 2
NOD1 CXCL14 0 0 77 175 1 1
NOD1 LYZ 0 0 163 195 1 1
NOD1 PIK3C3 0 0 212 212 1 2
NOD1 NLRC3 0 0 683 368 1 1
NOD1 MPO 0 0 234 234 1 2
NOD1 OCLN 0 0 202 202 1 1
NOD1 IL17D 0 0 95 151 1 1
NOD1 TNFRSF1A 0 0 375 388 1 1
NOD1 DEFB1 0 0 372 372 1 1
NOD1 SBK1 0 0 58 315 1 1
NOD1 DEFB125 0 0 107 264 1 1
NOD1 STAT1 0 0 369 384 1 2
NOD1 RNASE1 0 0 51 165 1 1
NOD1 CD40LG 0 0 256 256 1 1
NOD1 ENTPD1 0 0 60 154 1 1
NOD1 RNF138 0 0 87 154 1 1
NOD1 NOTCH1 0 0 125 156 1 2
NOD1 DEFB128 0 0 112 269 1 1
NOD1 RPL14 0 0 0 252 1 1
NOD1 CXCR4 0 0 143 164 1 2
NOD1 TRAF4 270 0 261 451 1 1
NOD1 POTEF 0 0 139 164 1 1
NOD1 SPINK5 0 0 328 328 1 1
NOD1 MTOR 0 0 147 165 1 2
NOD1 TAMM41 0 0 56 262 1 1
NOD1 NLRP1 213 0 717 472 1 1
NOD1 TRAF1 0 0 218 290 1 1
NOD1 CAMP 0 0 335 335 1 2
NOD1 PYROXD1 0 0 75 393 1 1
NOD1 CARD9 0 600 557 894 1 1
NOD1 MUC5B 0 0 134 196 1 1
NOD1 CSF3 0 0 279 279 1 1
NOD1 IRAK1 0 600 501 791 1 1
NOD1 CRADD 0 0 431 431 1 1
NOD1 NFKBIZ 0 0 204 232 1 1
NOD1 ADAM33 0 0 324 323 1 1
NOD1 ZBP1 0 0 204 227 1 1
NOD1 LCP2 0 0 94 280 1 1
NOD1 NLRP4 0 0 558 269 1 1
NOD1 MAP3K7 0 600 342 725 1 2
NOD1 TAAR5 0 0 166 165 1 1
NOD1 BNIP2 0 0 150 168 1 1
NOD1 CFTR 0 0 166 184 1 2
NOD1 NR1H2 0 0 328 328 1 1
NOD1 AP3D1 0 0 0 165 1 1
NOD1 IRF9 0 0 165 183 1 1
NOD1 ERCC2 0 0 0 164 1 1
NOD1 TP53 0 0 201 201 1 2
NOD1 LCN2 0 0 155 162 1 1
NOD1 MYD88 0 0 686 754 1 2
NOD1 DEFB103A 0 0 405 405 1 1
NOD1 CFLAR 270 0 267 462 1 2
NOD1 EGFR 0 0 193 193 1 2
NOD1 TSLP 0 0 358 358 1 1
NOD1 LAMP1 0 0 173 185 1 2
NOD1 FADD 0 0 323 323 1 2
NOD1 ESX1 0 0 269 281 1 1
NOD1 SARM1 0 0 202 206 1 1
NOD1 MUC5AC 0 0 144 205 1 1
NOD1 NASP 0 0 45 321 1 1
NOD1 GATA3 0 0 170 176 1 1
NOD1 MVB12A 0 0 0 155 1 1
NOD1 SLC9A4 0 0 327 327 1 1
NOD1 ERN1 0 0 244 243 1 2
NOD1 DEFA5 0 0 134 154 1 1
NOD1 CD300C 0 0 204 221 1 1
NOD1 STAT3 0 0 296 311 1 2
NOD1 PTPN22 0 0 119 158 1 1
NOD1 CDK14 0 0 57 234 1 1
NOD1 APAF1 0 0 465 508 1 2
NOD1 REG3G 0 0 203 237 1 1
NOD1 BRD7 0 0 0 262 1 1
NOD1 NLRC5 0 0 662 415 1 1
NOD1 PLEKHA8 0 0 87 396 1 1
NOD1 JAK2 0 0 180 208 1 2
NOD1 NKD1 0 0 0 220 1 1
NOD1 PYROXD2 0 0 61 367 1 1
NOD1 CCL26 0 0 414 414 1 1
NOD1 DHX33 0 0 137 169 1 1
NOD1 ARHGEF28 0 0 0 189 1 1
NOD1 MX1 0 0 124 155 1 1
NOD1 TAB1 0 600 414 777 1 1
NOD1 SLC15A4 0 0 579 593 1 1
NOD1 TRAF2 0 0 290 350 1 2
NOD1 MEFV 0 0 683 692 1 1
NOD1 IL18 0 0 663 676 1 2
NOD1 IFNA1 0 0 401 400 1 1
NOD1 ITGAE 0 0 273 273 1 1
NOD1 MYC 0 0 208 208 1 2
NOD1 IRGM 270 0 564 676 1 2
NOD1 IL15 0 0 218 236 1 1
NOD1 IL1R1 0 0 459 459 1 1
NOD1 PPP5C 145 0 57 197 1 1
NOD1 TREM1 0 0 280 314 1 1
NOD1 AZI2 0 0 66 311 1 1
NOD1 TAB2 0 600 403 755 1 2
NOD1 ENSG00000254536 0 0 0 195 1 1
NOD1 RB1CC1 0 0 170 258 1 2
NOD1 NLRP10 0 0 722 343 1 1
NOD1 TLR1 0 0 699 720 1 1
NOD1 MAP3K8 0 0 183 222 1 1
NOD1 CARD10 0 0 229 260 1 1
NOD1 FZD2 0 0 0 157 1 1
NOD1 DHX58 0 0 468 508 1 1
NOD1 BRD9 0 0 0 159 1 1
NOD1 RBCK1 0 0 202 221 1 1
NOD1 CD80 0 0 270 286 1 2
NOD1 NLRP12 0 0 604 274 1 1
NOD1 NOL3 0 0 218 218 1 1
NOD1 UBD 0 0 432 432 1 1
NOD1 ACTA1 0 0 182 199 1 1
NOD1 LY75 0 0 167 167 1 1
NOD1 CASP10 0 0 125 205 1 1
NOD1 DEDD2 0 0 172 481 1 1
NOD1 CXCR5 0 0 113 593 1 1
NOD1 IL5RA 0 0 108 261 1 1
NOD1 TFF2 0 0 122 162 1 1
NOD1 C3 0 0 226 242 1 2
NOD1 PGLYRP4 0 0 370 370 1 1
NOD1 FN1 0 0 202 219 1 2
NOD1 IKBKG 0 600 518 808 1 1
NOD1 CCR7 0 0 156 186 1 1
NOD1 ULK1 0 0 210 210 1 2
NOD1 TBX21 0 0 235 251 1 1
NOD1 PKN3 0 0 0 154 1 1
NOD1 GNPTG 0 0 53 310 1 1
NOD1 RIPK4 0 0 181 181 1 1
NOD1 PKN1 0 0 108 262 1 1
NOD1 ELANE 0 0 137 164 1 1
NOD1 NFKBIB 0 0 218 232 1 1
NOD1 SLC15A3 0 0 456 466 1 1
NOD1 SUGT1 675 800 189 950 1 1
NOD1 UBC 927 0 59 932 1 2
NOD1 MAP1LC3B 0 0 123 176 1 2
NOD1 URGCP 0 0 351 351 1 1
NOD1 CMA1 0 0 297 304 1 1
NOD1 PTPN1 0 0 66 188 1 1
NOD1 SLC22A5 0 0 151 150 1 1
NOD1 IRF1 0 0 310 345 1 2
NOD1 CXCR3 0 0 155 154 1 1
NOD1 STAT2 0 0 217 234 1 1
NOD1 XBP1 0 0 235 235 1 2
NOD1 TLR8 0 0 565 598 1 1
NOD1 TRIP6 0 0 441 441 1 1
NOD1 LGR5 0 0 150 168 1 1
NOD1 ATG5 0 0 418 422 1 2
NOD1 MAP2K6 0 900 74 903 1 1
NOD1 CALCOCO2 0 0 377 377 1 2
NOD1 NLRP14 0 0 342 197 1 1
NOD1 IRF5 0 0 294 311 1 1
NOD1 HMGB1 0 0 335 350 1 2
NOD1 DUOX2 0 0 134 375 1 1
NOD1 IFNB1 0 0 561 564 1 1
NOD1 ACKR2 0 0 155 154 1 1
NOD1 MAP3K5 0 0 115 165 1 1
NOD1 OPTN 0 0 204 204 1 2
NOD1 ITGAM 0 0 325 346 1 1
NOD1 RNH1 0 0 462 209 1 1
NOD1 IL10RB 0 0 123 165 1 1
NOD1 MCL1 0 0 166 184 1 2
NOD1 NKX2-3 0 0 327 327 1 2
NOD1 CTSB 0 0 252 260 1 2
NOD1 SPI1 0 0 260 322 1 1
NOD1 MAPK10 0 0 113 168 1 2
NOD1 CDX2 0 0 124 159 1 1
NOD1 TP53BP2 0 0 150 208 1 2
NOD1 MARK2 0 0 150 192 1 1
NOD1 UBA52 800 0 0 800 1 1
NOD1 GOPC 0 0 66 159 1 2
NOD1 FCGR2A 0 0 141 174 1 1
NOD1 IL21R 0 0 293 312 1 1
NOD1 CLEC4E 0 0 391 390 1 1
NOD1 MAPK14 0 650 193 731 1 2
NOD1 SDCCAG3 0 0 330 330 1 1
NOD1 NFKBIA 0 0 505 515 1 2
NOD1 RHOT2 0 0 0 256 1 1
NOD1 LEP 0 0 142 161 1 1
NOD1 SYK 0 0 298 314 1 2
NOD1 MAP3K3 0 0 108 179 1 1
NOD1 FFAR4 0 0 92 155 1 1
NOD1 NFATC1 0 0 83 163 1 2
NOD1 TRAF7 0 0 186 217 1 1
NOD1 WIPI1 0 0 134 162 1 2
NOD1 CASP5 0 0 391 502 1 1
NOD1 SALL1 0 0 0 208 1 1
NOD1 LTA4H 0 0 92 158 1 1
NOD1 NLRP6 0 0 681 325 1 1
NOD1 IRF4 0 0 211 228 1 1
NOD1 GABARAP 0 0 137 155 1 2
NOD1 CXCL2 0 0 391 463 1 1
NOD1 IRAK4 0 0 424 428 1 1
NOD1 MS4A2 0 0 388 388 1 1
NOD1 IL10 0 0 519 552 1 2
NOD1 CCL20 0 0 391 390 1 1
NOD1 ACTG1 0 0 149 210 1 1
NOD1 OTUD5 0 0 140 180 1 1
NOD1 TRAT1 0 0 141 159 1 1
NOD1 USP34 0 0 74 172 1 1
NOD1 TJP1 0 0 180 179 1 1
NOD1 ATG7 0 0 288 288 1 2
NOD1 CCL22 0 0 156 155 1 1
NOD1 CTSG 0 0 170 202 1 1
NOD1 CCL3 0 0 273 273 1 1
NOD1 ICAM3 0 0 171 201 1 1
NOD1 COPS7A 0 0 73 167 1 1
NOD1 IL18RAP 0 0 150 236 1 1
NOD1 SULT2B1 0 0 387 386 1 1
NOD1 IL23A 0 0 233 255 1 1
NOD1 MARCO 0 0 134 175 1 1
NOD1 BLK 0 0 95 280 1 1
NOD1 SLC11A1 0 0 294 294 1 1
NOD1 ITGAX 0 0 324 338 1 1
NOD1 MRC1 0 0 150 297 1 1
NOD1 CASP4 270 600 217 803 1 2
NOD1 RPS27A 800 0 0 800 1 1
NOD1 CHUK 0 900 457 943 1 1
NOD1 PIGR 0 0 259 258 1 1
NOD1 NLRP11 0 0 391 202 1 1
NOD1 CD5L 0 0 385 384 1 1
NOD1 MCHR2 0 0 235 277 1 1
NOD1 DUSP2 0 0 57 191 1 1
NOD1 ATG16L1 486 800 984 998 1 2
NOD1 CEBPB 0 0 151 175 1 2
NOD1 NOD2 270 600 941 764 1 2
NOD1 CIITA 0 0 612 361 1 1
NOD1 PTGES3 130 0 0 161 1 1
NOD1 CSF1 0 0 194 219 1 1
NOD1 RIPK1 0 0 378 400 1 2
NOD1 LTBR 0 0 242 258 1 1
NOD1 HSPB8 270 0 0 270 1 2
NOD1 ATG101 0 0 123 457 1 2
NOD1 REL 0 0 268 268 1 2
NOD1 NLRP3 0 0 851 401 1 2
NOD1 HSPA1B 270 0 0 270 1 1
NOD1 NUF2 0 0 0 165 1 1
NOD1 CARD16 0 0 75 288 1 1
NOD1 PLA2G7 0 0 385 384 1 1
NOD1 IL33 0 0 403 403 1 2
NOD1 CXCL1 0 0 427 495 1 2
NOD1 UBE2V1 0 600 164 651 1 1
NOD1 AICDA 0 0 155 291 1 1
NOD1 CCL11 0 0 328 342 1 1
NOD1 PTGS2 0 0 261 279 1 2
NOD1 CASP3 0 0 273 284 1 2
NOD1 PGLYRP1 0 0 556 556 1 1
NOD1 IL1RL1 0 0 193 193 1 1
NOD1 ATG12 0 0 363 377 1 2
NOD1 IL13 0 0 369 369 1 2
NOD1 SRPK3 0 0 0 183 1 1
NOD1 TNFSF13B 0 0 268 292 1 1
NOD1 CXCL5 0 0 193 335 1 1
NOD1 NR2C2 0 0 65 209 1 1
NOD1 CYBB 0 0 206 288 1 2
NOD1 CD28 0 0 208 214 1 1
NOD1 IL2 0 0 310 309 1 1
NOD1 TLR6 0 0 601 623 1 1
NOD1 CCL7 0 0 154 176 1 1
NOD1 BECN1 0 0 325 332 1 2
NOD1 TRAF3 0 0 647 672 1 2
NOD1 MET 0 0 112 152 1 2
NOD1 TOLLIP 0 0 282 282 1 1
NOD1 LRRK2 0 0 210 211 1 2
NOD1 TLR2 0 0 853 874 1 2
NOD1 PMAIP1 0 0 433 433 1 2
NOD1 DUSP1 0 0 181 213 1 1
NOD1 MAPK11 0 650 134 700 1 1
NOD1 TBKBP1 0 0 140 165 1 1
NOD1 GALE 0 0 0 224 1 1
NOD1 PGLYRP3 0 0 380 444 1 1
NOD1 CD86 0 0 322 344 1 1
NOD1 IL18R1 0 0 170 169 1 1
NOD1 CARD11 0 0 260 291 1 1
NOD1 SHARPIN 0 0 229 248 1 1
NOD1 CFB 0 0 134 185 1 1
NOD1 CLEC9A 0 0 134 167 1 1
NOD1 SOCS3 0 0 241 280 1 1
NOD1 S100A8 0 0 556 559 1 2
NOD1 CCL27 0 0 213 213 1 1
NOD1 FOS 0 0 161 161 1 2
NOD1 FASLG 0 0 187 187 1 1
NOD1 DGKD 0 0 0 214 1 1
NOD1 EIF1AD 0 0 81 320 1 1
NOD1 IRAK3 0 0 270 292 1 1
NOD1 TNIP1 0 0 218 257 1 1
NOD1 MLEC 0 0 52 198 1 1
NOD1 SIGIRR 0 0 323 347 1 1
NOD1 PTPN11 0 0 240 248 1 1
NOD1 TIFA 0 0 164 240 1 1
NOD1 COPS6 270 0 447 589 1 1
NOD1 SRPK2 0 0 0 183 1 1
NOD1 ZNRF2 0 0 81 312 1 1
NOD1 RNF34 270 0 155 356 1 1
NOD1 STAT5A 0 0 96 166 1 1
NOD1 VIPR1 0 0 224 224 1 1
NOD1 HLA-B 0 0 112 178 1 1
NOD1 CCL17 0 0 233 232 1 1
NOD1 IFNGR1 0 0 194 211 1 1
NOD1 UEVLD 0 0 0 156 1 1
NOD1 ITGB2 0 0 137 169 1 1
NOD1 PKN2 0 0 0 157 1 1
NOD1 IRF3 0 0 550 550 1 2
NOD1 CTSC 0 0 48 157 1 1
NOD1 NLRP7 0 0 518 290 1 1
NOD1 PYCARD 0 0 597 635 1 2
NOD1 CD1D 0 0 208 208 1 1
NOD1 IGF2R 0 0 66 235 1 1
NOD1 CARD6 270 0 631 727 1 1
NOD1 ENTPD3 0 0 57 347 1 1
NOD1 MTURN 0 0 91 339 1 1
NOD1 CXorf21 0 0 167 167 1 1
NOD1 TLR9 0 0 681 713 1 2
NOD1 HSP90AB1 114 0 57 399 1 2
NOD1 CXCL10 0 0 340 354 1 2
NOD1 MALT1 0 0 323 390 1 1
NOD1 CYLD 0 900 304 927 1 1
NOD1 PIKFYVE 0 0 64 219 1 2
NOD1 C9orf89 0 0 241 240 1 1
NOD1 ITPKC 0 0 103 155 1 1
NOD1 PPP3CA 0 0 54 156 1 1
NOD1 XIAP 270 0 414 553 1 2
NOD1 SCGB2A1 0 0 385 384 1 1
NOD1 RPLP2 0 0 0 204 1 1
NOD1 SATB1 0 0 0 302 1 1
NOD1 DUOX1 0 0 102 352 1 1
NOD1 PANX1 0 0 243 242 1 1
NOD1 DEFB135 0 0 153 243 1 1
NOD1 NLRC4 270 0 813 561 1 2
NOD1 IKBKB 0 900 460 943 1 2
NOD1 ATF6 0 0 150 168 1 2
NOD1 FAS 0 0 155 173 1 2
NOD1 SUMO1 0 0 0 211 1 1
NOD1 CARD8 0 0 503 510 1 1
NOD1 CARD14 0 0 171 275 1 1
NOD1 GARS 0 0 48 212 1 1
NOD1 VCAM1 0 0 181 210 1 1
NOD1 INPP5D 0 0 76 162 1 1
NOD1 CD4 0 0 469 486 1 2
NOD1 MBTPS1 0 0 0 159 1 1
NOD1 PPARG 0 0 194 211 1 2
NOD1 AAMP 0 0 166 210 1 1
NOD1 GBP2 0 0 123 179 1 1
NOD1 AKT1 0 0 286 306 1 2
NOD1 LY96 0 0 506 538 1 1
NOD1 CSF2 0 0 402 402 1 1
NOD1 IL12RB1 0 0 142 196 1 1
NOD1 REG3A 0 0 172 208 1 1
NOD1 IFIT1 0 0 150 165 1 1
NOD1 ADCY4 0 0 0 168 1 1
NOD1 RIPK3 0 0 243 274 1 2
NOD1 PRKCD 0 0 154 252 1 2
NOD1 TEP1 0 0 95 150 1 1
NOD1 ENSG00000244255 0 0 101 154 1 1
NOD1 SCGB1A1 0 0 249 248 1 1
NOD1 GHITM 0 0 113 221 1 1
NOD1 BNIP3L 0 0 164 182 1 2
NOD1 TGFB1 0 0 112 213 1 2
NOD1 GADD45G 0 0 143 196 1 1
NOD1 RAB7B 0 0 181 199 1 1
NOD1 RAC2 0 0 141 173 1 1
NOD1 JAK1 0 0 201 201 1 2
NOD1 SKP1 0 0 124 223 1 2
NOD1 NWD1 0 0 171 534 1 1
NOD1 ERAL1 0 0 48 317 1 1
NOD1 IL32 0 0 778 778 1 1
NOD1 FOXP3 0 0 325 325 1 2
NOD1 CLEC5A 0 0 127 214 1 1
NOD1 TICAM2 0 0 202 260 1 1
NOD1 TBK1 0 0 468 475 1 2
NOD1 STAT6 0 0 208 237 1 1
NOD1 FRMPD2 0 0 254 263 1 1
NOD1 LGALS3 0 0 161 175 1 2
NOD1 ATG3 0 0 171 182 1 2
NOD1 RSAD2 0 0 124 165 1 1
NOD1 METTL6 0 0 75 386 1 1
NOD1 BIRC6 0 0 104 161 1 1
NOD1 TLR3 0 0 726 743 1 2
NOD1 IRF8 0 0 180 213 1 1
NOD1 SRC 0 0 242 257 1 2
NOD1 CDC42 0 0 264 264 1 2
NOD1 RAG1 0 0 193 193 1 1
NOD1 TNFSF11 0 0 218 235 1 2
NOD1 EEA1 0 0 134 164 1 2
NOD1 BPI 0 0 123 182 1 1
NOD1 CD274 0 0 155 202 1 2
NOD1 HSF2 0 0 67 285 1 1
NOD1 TIMD4 0 0 140 158 1 1
NOD1 FAM192A 0 0 95 402 1 1
NOD1 IRAK2 0 600 306 711 1 1
NOD1 BLNK 0 0 90 155 1 1
NOD1 C8A 0 0 56 278 1 1
NOD1 PAXIP1 0 0 0 208 1 1
NOD1 CD19 0 0 144 163 1 1
NOD1 SNX20 0 0 74 279 1 1
NOD1 AHR 0 0 181 181 1 2
NOD1 NLRP2 0 0 391 243 1 1
NOD1 UBB 800 0 61 814 1 1
NOD1 CAT 0 0 134 153 1 2
NOD1 PDPK1 0 0 0 262 1 2
NOD1 MRGBP 0 0 50 222 1 1
NOD1 ATG2A 0 0 86 168 1 2
NOD1 DEFB134 0 0 166 223 1 1
NOD1 NDUFA13 0 0 195 195 1 1
NOD1 FSTL1 0 0 334 334 1 1
NOD1 HPRT1 0 0 137 152 1 1
NOD1 RNASEL 0 0 136 195 1 1
NOD1 PTPN2 0 0 264 286 1 2
NOD1 BAK1 0 0 141 168 1 2
NOD1 COLEC12 0 0 81 197 1 1
NOD1 CCL19 0 0 150 178 1 1
NOD1 CARD18 0 0 374 383 1 1
NOD1 TECPR1 0 0 282 282 1 1
NOD1 DFFA 0 0 69 182 1 1
NOD1 CHORDC1 0 0 108 483 1 1
NOD1 PSMA7 270 0 108 321 1 1
NOD1 CTLA4 0 0 265 271 1 2
NOD1 MUC7 0 0 357 357 1 1
NOD1 IL23R 0 0 320 319 1 1
NOD1 C11orf30 0 0 167 219 1 1
NOD1 ITCH 0 900 232 919 1 1
NOD1 ADCY7 0 0 0 210 1 1
NOD1 TRAF3IP3 0 0 124 463 1 1
NOD1 NAIP 0 0 650 690 1 1
NOD1 SCGB3A2 0 0 357 357 1 1
NOD1 WIPI2 0 0 201 201 1 2
NOD1 CD209 0 0 359 359 1 1
NOD1 ANKRD26 0 0 62 262 1 1
NOD1 CD44 0 0 148 223 1 2
NOD1 IL7 0 0 211 211 1 1
NOD1 IL1RN 0 0 161 181 1 1
NOD1 CASP2 270 600 240 762 1 1
NOD1 NBR1 0 0 264 264 1 2
NOD1 TANK 0 0 259 258 1 2
NOD1 TNF 0 0 614 640 1 2
NOD1 TIRAP 0 0 469 469 1 1
NOD1 DDX53 0 0 180 207 1 1
NOD1 AGK 0 0 0 187 1 1
NOD1 DEFB4A 0 0 501 501 1 1
NOD1 IRF7 0 0 452 484 1 1
NOD1 BTK 0 0 73 162 1 1
NOD1 SOCS1 0 0 211 246 1 1
NOD1 FFAR3 0 0 218 224 1 1
NOD1 IFI35 0 0 95 155 1 1
NOD1 GBP5 0 0 181 218 1 1
NOD1 RELB 0 0 216 251 1 2
NOD1 RAB7A 0 0 181 205 1 2
NOD1 CXCL3 0 0 173 271 1 1
NOD1 TXNIP 0 0 202 235 1 2
NOD1 FNBP1L 0 0 150 208 1 1
NOD1 IFI16 0 0 370 401 1 1
NOD1 BCL2A1 0 0 161 208 1 1
NOD1 IFNAR1 0 0 310 309 1 1
NOD1 ENSG00000272980 0 0 262 263 1 1
NOD1 MAP3K14 0 0 66 156 1 1
NOD1 CD70 0 0 140 176 1 1
NOD1 IL5 0 0 320 319 1 1
NOD1 TNFAIP3 0 900 240 924 1 2
NOD1 GCG 0 0 100 193 1 1
NOD1 NFKB2 0 0 242 271 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005524 Molecular Function ATP binding enables IEA
GO:0050700 Molecular Function CARD domain binding enables IDA
GO:0008656 Molecular Function cysteine-type endopeptidase activator activity involved in apoptotic process enables TAS
GO:0042802 Molecular Function identical protein binding enables IDA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0038187 Molecular Function pattern recognition receptor activity enables IDA
GO:0001653 Molecular Function peptide receptor activity enables IDA
GO:0042834 Molecular Function peptidoglycan binding enables IDA
GO:0042834 Molecular Function peptidoglycan binding enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IPI
GO:0044877 Molecular Function protein-containing complex binding enables IPI
GO:0043130 Molecular Function ubiquitin binding enables IDA
GO:0070371 Biological Process ERK1 and ERK2 cascade involved_in IEA
GO:0007254 Biological Process JNK cascade involved_in IEA
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process acts_upstream_of_or_within IDA
GO:0006915 Biological Process apoptotic process involved_in IEA
GO:0007249 Biological Process canonical NF-kappaB signal transduction involved_in IEA
GO:0071225 Biological Process cellular response to muramyl dipeptide involved_in IMP
GO:0006952 Biological Process defense response involved_in TAS
GO:0050829 Biological Process defense response to Gram-negative bacterium involved_in IDA
GO:0050830 Biological Process defense response to Gram-positive bacterium involved_in IEA
GO:0042742 Biological Process defense response to bacterium involved_in IDA
GO:0016045 Biological Process detection of bacterium involved_in IDA
GO:0009595 Biological Process detection of biotic stimulus involved_in TAS
GO:0006954 Biological Process inflammatory response involved_in TAS
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0035556 Biological Process intracellular signal transduction involved_in IBA
GO:0035556 Biological Process intracellular signal transduction involved_in IDA
GO:0070427 Biological Process nucleotide-binding oligomerization domain containing 1 signaling pathway involved_in IDA
GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in IDA
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IEA
GO:0046330 Biological Process positive regulation of JNK cascade involved_in IEA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IEA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction acts_upstream_of_or_within IDA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IDA
GO:0043280 Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process acts_upstream_of_or_within IDA
GO:0002606 Biological Process positive regulation of dendritic cell antigen processing and presentation involved_in ISS
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IEA
GO:0032755 Biological Process positive regulation of interleukin-6 production involved_in IEA
GO:0032757 Biological Process positive regulation of interleukin-8 production involved_in IDA
GO:0060907 Biological Process positive regulation of macrophage cytokine production involved_in IEA
GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in IMP
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IEA
GO:1904417 Biological Process positive regulation of xenophagy involved_in IEA
GO:0034976 Biological Process response to endoplasmic reticulum stress involved_in IEA
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0098792 Biological Process xenophagy involved_in IEA
GO:0016324 Cellular Component apical plasma membrane located_in IEA
GO:0016323 Cellular Component basolateral plasma membrane located_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005737 Cellular Component cytoplasm located_in TAS
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0045335 Cellular Component phagocytic vesicle located_in IEA
GO:0005886 Cellular Component plasma membrane is_active_in IDA
GO:0005886 Cellular Component plasma membrane located_in IMP
Pathways
Name DB ID
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Reactome R-HSA-166058
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
Toll Like Receptor 10 (TLR10) Cascade Reactome R-HSA-168142
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade Reactome R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade Reactome R-HSA-168179
Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade Reactome R-HSA-168188
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
NOD1/2 Signaling Pathway Reactome R-HSA-168638
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
Toll-like Receptor Cascades Reactome R-HSA-168898
Toll Like Receptor 2 (TLR2) Cascade Reactome R-HSA-181438
Metabolism of proteins Reactome R-HSA-392499
TAK1-dependent IKK and NF-kappa-B activation Reactome R-HSA-445989
Interleukin-1 family signaling Reactome R-HSA-446652
Interleukin-17 signaling Reactome R-HSA-448424
Signaling by Interleukins Reactome R-HSA-449147
MAP kinase activation Reactome R-HSA-450294
activated TAK1 mediates p38 MAPK activation Reactome R-HSA-450302
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Reactome R-HSA-450321
Infectious disease Reactome R-HSA-5663205
Deubiquitination Reactome R-HSA-5688426
Ovarian tumor domain proteases Reactome R-HSA-5689896
Post-translational protein modification Reactome R-HSA-597592
Interleukin-1 signaling Reactome R-HSA-9020702
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
SARS-CoV Infections Reactome R-HSA-9679506
SARS-CoV-2 Infection Reactome R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
SARS-CoV-2-host interactions Reactome R-HSA-9705683
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome R-HSA-975138
MyD88 dependent cascade initiated on endosome Reactome R-HSA-975155
MyD88 cascade initiated on plasma membrane Reactome R-HSA-975871
Viral Infection Pathways Reactome R-HSA-9824446
Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
Burn wound healing (WP5055) WikiPathways WP5055_r122621
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_149002 2 miscRNA transcript variant 3 NC_000007 Reference
XR_007059981 1 miscRNA transcript variant X9 NC_000007 Reference
XR_926910 2 miscRNA transcript variant X30 NC_000007 Reference
XR_001744530 2 miscRNA transcript variant X29 NC_000007 Reference
XM_047419760 1 mRNA transcript variant X16 NC_000007 Reference
XM_005249572 1 mRNA transcript variant X5 NC_000007 Reference
XM_047419763 1 mRNA transcript variant X19 NC_000007 Reference
XM_047419753 1 mRNA transcript variant X7 NC_000007 Reference
XM_047419765 1 mRNA transcript variant X22 NC_000007 Reference
NM_001354849 2 mRNA transcript variant 2 NC_000007 Reference
NM_006092 4 mRNA transcript variant 1 NC_000007 Reference
XM_047419759 1 mRNA transcript variant X15 NC_000007 Reference
XM_047419768 1 mRNA transcript variant X25 NC_000007 Reference
XM_047419762 1 mRNA transcript variant X18 NC_000007 Reference
XM_011515083 2 mRNA transcript variant X6 NC_000007 Reference
XM_011515085 2 mRNA transcript variant X21 NC_000007 Reference
XM_011515084 2 mRNA transcript variant X10 NC_000007 Reference
XM_005249568 2 mRNA transcript variant X1 NC_000007 Reference
XM_047419761 1 mRNA transcript variant X17 NC_000007 Reference
XM_047419766 1 mRNA transcript variant X23 NC_000007 Reference
XM_047419755 1 mRNA transcript variant X11 NC_000007 Reference
XM_047419752 1 mRNA transcript variant X2 NC_000007 Reference
XM_047419758 1 mRNA transcript variant X14 NC_000007 Reference
XM_006715633 3 mRNA transcript variant X4 NC_000007 Reference
XM_047419767 1 mRNA transcript variant X24 NC_000007 Reference
XM_047419756 1 mRNA transcript variant X12 NC_000007 Reference
XM_011515079 1 mRNA transcript variant X3 NC_000007 Reference
XM_047419754 1 mRNA transcript variant X8 NC_000007 Reference
XM_047419757 1 mRNA transcript variant X13 NC_000007 Reference
XM_047419764 1 mRNA transcript variant X20 NC_000007 Reference
XM_047419770 1 mRNA transcript variant X32 NC_000007 Reference
XM_005249576 1 mRNA transcript variant X31 NC_000007 Reference
XM_011515087 2 mRNA transcript variant X26 NC_000007 Reference
XM_011515088 3 mRNA transcript variant X27 NC_000007 Reference
XM_047419769 1 mRNA transcript variant X28 NC_000007 Reference