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TRIM16

tripartite motif containing 16
General Information
Name tripartite motif containing 16
Alias
  • tripartite motif-containing protein 16
  • E3 ubiquitin-protein ligase TRIM16
  • estrogen-responsive B box protein
Gene_family Tripartite motif family
organism Homo sapiens
entrez_id 10626
location 17p12
transcript_count 8
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]
    Stringdb Tripartite motif-containing protein 16; May play a role in the regulation of keratinocyte differentiation; Tripartite motif containing
    nextProt E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TRIM16 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID ORF1ab GeneID BioGRID Biochemical Activity
TRIM16 BioGRID MAPK3 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID MAPK1 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID MCMBP GeneID BioGRID Co-fractionation
TRIM16 BioGRID PBK GeneID BioGRID Co-fractionation
TRIM16 BioGRID UCHL5 GeneID BioGRID Co-fractionation
TRIM16 BioGRID NRBP1 GeneID BioGRID Co-fractionation
TRIM16 BioGRID RABGAP1 GeneID BioGRID Co-fractionation
TRIM16 BioGRID LARP1 GeneID BioGRID Co-fractionation
TRIM16 BioGRID KIF1B GeneID BioGRID Co-fractionation
TRIM16 BioGRID HSPH1 GeneID BioGRID Co-fractionation
TRIM16 BioGRID ARFGEF1 GeneID BioGRID Co-fractionation
TRIM16 BioGRID RAD50 GeneID BioGRID Co-fractionation
TRIM16 BioGRID PDIA4 GeneID BioGRID Co-fractionation
TRIM16 BioGRID PSMC5 GeneID BioGRID Co-fractionation
TRIM16 BioGRID PPP1CA GeneID BioGRID Co-fractionation
TRIM16 BioGRID KLC1 GeneID BioGRID Co-fractionation
TRIM16 BioGRID KIF5B GeneID BioGRID Co-fractionation
TRIM16 BioGRID HNRNPF GeneID BioGRID Co-fractionation
TRIM16 BioGRID TRIM16L GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID USP38 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID TRIM7 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID PINK1 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID SLC39A4 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID CCDC22 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID NUP62 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID MBNL1 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID CCR1 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID ORF3a GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID ACACA GeneID BioGRID Positive Genetic
TRIM16 BioGRID DEPTOR GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID RRAGD GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID RRAGB GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID CUL4A GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID ULK1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TRIM16 BioGRID CUL5 GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID TFEB GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID PPP3CB GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID LGALS3 GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID LGALS2 GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID OPTN GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID Sidt2 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID Gnpnat1 GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID Rhoa GeneID BioGRID Affinity Capture-MS
TRIM16 BioGRID NXF1 GeneID BioGRID Affinity Capture-RNA
TRIM16 BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
TRIM16 BioGRID HSP90AB2P GeneID BioGRID Co-fractionation
TRIM16 BioGRID CLUH GeneID BioGRID Co-fractionation
TRIM16 BioGRID TOMM34 GeneID BioGRID Co-fractionation
TRIM16 BioGRID MCM7 GeneID BioGRID Co-fractionation
TRIM16 BioGRID APP GeneID BioGRID Reconstituted Complex
TRIM16 BioGRID ACD GeneID BioGRID Two-hybrid
TRIM16 BioGRID TINF2 GeneID BioGRID Two-hybrid
TRIM16 BioGRID POT1 GeneID BioGRID Two-hybrid
TRIM16 BioGRID TERF1 GeneID BioGRID Two-hybrid
TRIM16 BioGRID VIM GeneID BioGRID Affinity Capture-Western
TRIM16 BioGRID E2F1 GeneID BioGRID Affinity Capture-Western
TRIM16 Protein SETDB1 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
TRIM16 TRIM25 0 0 465 211 1 1
TRIM16 SEMA7A 0 0 0 357 1 1
TRIM16 PIGP 0 0 140 163 1 1
TRIM16 HMGB2 0 0 112 524 1 1
TRIM16 GMFG 0 0 151 236 1 1
TRIM16 PML 0 0 525 525 1 2
TRIM16 TRIM43 0 0 170 169 1 1
TRIM16 GAPDH 0 0 156 171 1 2
TRIM16 ING1 0 0 157 156 1 1
TRIM16 ATG14 0 0 218 218 1 2
TRIM16 GABARAPL2 0 0 215 215 1 2
TRIM16 IKBKB 0 0 95 234 1 2
TRIM16 HNRNPUL2 0 0 167 499 1 1
TRIM16 POMP 0 0 45 288 1 1
TRIM16 TSPAN11 0 0 0 188 1 1
TRIM16 LGALS9B 0 0 0 250 1 1
TRIM16 TRIM9 0 0 262 262 1 1
TRIM16 FBXO25 0 0 167 168 1 1
TRIM16 RPA3 0 0 81 247 1 1
TRIM16 TRIM36 0 0 151 161 1 1
TRIM16 TAP1 0 0 102 253 1 1
TRIM16 IRF3 0 0 171 206 1 2
TRIM16 TRIM2 0 0 222 358 1 1
TRIM16 LGALS9 0 0 151 336 1 1
TRIM16 TLR9 0 0 73 208 1 2
TRIM16 PYCARD 0 0 48 353 1 2
TRIM16 TRIM58 0 0 252 170 1 1
TRIM16 TRIM59 0 0 463 466 1 1
TRIM16 TRPV2 0 0 124 178 1 1
TRIM16 BBOX1 0 0 604 604 1 1
TRIM16 MED15 0 0 181 181 1 1
TRIM16 PIK3C3 0 0 157 156 1 2
TRIM16 TP53INP1 0 0 604 604 1 2
TRIM16 BRMS1L 0 0 107 292 1 1
TRIM16 NLRC3 0 0 167 413 1 1
TRIM16 TRIM7 0 0 269 179 1 1
TRIM16 SRXN1 0 0 171 196 1 1
TRIM16 YOD1 0 0 137 169 1 1
TRIM16 TRIM37 0 0 337 488 1 1
TRIM16 TRIM71 0 0 158 157 1 1
TRIM16 ATG3 0 0 122 191 1 2
TRIM16 LGALS3 270 0 969 977 1 2
TRIM16 TMPRSS11E 0 0 180 179 1 1
TRIM16 TRIM52 0 0 325 329 1 1
TRIM16 DNMBP 0 0 167 332 1 1
TRIM16 TLR3 0 0 123 478 1 2
TRIM16 TRIM28 0 0 301 459 1 2
TRIM16 GCK 0 0 45 180 1 1
TRIM16 TRIM27 0 0 520 232 1 1
TRIM16 STX17 0 0 372 381 1 2
TRIM16 IL1B 0 0 866 866 1 2
TRIM16 TRIM66 0 0 320 319 1 1
TRIM16 TRIM49 0 0 283 282 1 1
TRIM16 CD82 0 0 52 310 1 1
TRIM16 CD151 0 0 57 219 1 1
TRIM16 TBK1 0 0 93 349 1 2
TRIM16 TRIM14 0 0 465 200 1 1
TRIM16 RQCD1 0 0 0 416 1 1
TRIM16 SPPL3 0 0 0 179 1 1
TRIM16 AKR1C3 0 0 174 173 1 1
TRIM16 ZFYVE1 0 0 167 167 1 2
TRIM16 TRIM13 0 0 306 425 1 1
TRIM16 CDRT4 0 0 324 378 1 1
TRIM16 LGALS9C 0 0 0 250 1 1
TRIM16 ACD 295 0 0 295 1 2
TRIM16 HERC5 0 0 0 252 1 1
TRIM16 IGSF9B 0 0 71 324 1 1
TRIM16 CDCA4 0 0 150 180 1 1
TRIM16 IKBKE 0 0 66 556 1 1
TRIM16 TRIM29 0 0 459 214 1 1
TRIM16 AKR1C1 0 0 248 248 1 1
TRIM16 NLRC5 0 0 73 316 1 1
TRIM16 RHEB 0 0 70 152 1 2
TRIM16 RTP3 0 0 180 179 1 1
TRIM16 ANKRD12 0 0 156 156 1 1
TRIM16 MSI2 0 0 93 163 1 1
TRIM16 CARD18 0 0 181 181 1 1
TRIM16 NQO2 0 0 181 181 1 1
TRIM16 NEK6 0 0 100 264 1 1
TRIM16 TRIM42 0 0 180 323 1 1
TRIM16 TRIM23 0 0 294 415 1 1
TRIM16 GCLM 0 0 322 321 1 1
TRIM16 MCM7 244 0 0 299 1 1
TRIM16 ZNF184 0 0 212 212 1 1
TRIM16 TRIM8 0 0 369 229 1 1
TRIM16 CD300C 0 0 205 205 1 1
TRIM16 TYW1 0 0 183 197 1 1
TRIM16 GINS3 0 0 134 466 1 1
TRIM16 TRIM24 0 0 358 362 1 1
TRIM16 ESX1 0 0 241 240 1 1
TRIM16 SNAP23 0 0 322 321 1 1
TRIM16 FAM129B 0 0 167 215 1 1
TRIM16 LGALS2 270 0 48 279 1 1
TRIM16 RCC1 0 0 372 372 1 1
TRIM16 GPR139 0 0 180 180 1 1
TRIM16 FGF7 0 0 642 642 1 1
TRIM16 PLEKHG2 0 0 75 216 1 1
TRIM16 TRIM40 0 0 172 171 1 1
TRIM16 TRIM15 0 0 302 155 1 1
TRIM16 ARF5 0 0 0 212 1 1
TRIM16 GMFB 0 0 0 192 1 1
TRIM16 CD9 0 0 0 499 1 1
TRIM16 TAX1BP1 0 0 232 241 1 2
TRIM16 RB1CC1 0 0 194 194 1 2
TRIM16 CIC 0 0 143 175 1 1
TRIM16 TRIM49C 0 0 366 366 1 1
TRIM16 ARMC10 0 0 204 224 1 1
TRIM16 UBE2Z 0 0 148 179 1 1
TRIM16 IRF7 0 0 134 227 1 1
TRIM16 HNRNPU 0 0 60 158 1 1
TRIM16 ANKS1B 0 0 140 165 1 1
TRIM16 LYG1 0 0 0 209 1 1
TRIM16 UBXN6 0 0 159 158 1 1
TRIM16 DHX58 0 0 170 169 1 1
TRIM16 CASP2 0 0 166 165 1 1
TRIM16 CDRT1 0 0 294 343 1 1
TRIM16 TRIM33 0 0 181 262 1 1
TRIM16 NR2C1 0 0 124 316 1 1
TRIM16 NBR1 0 0 167 167 1 2
TRIM16 FGF10 0 0 608 608 1 1
TRIM16 MEFV 0 0 374 187 1 1
TRIM16 EGLN3 0 0 53 302 1 1
TRIM16 SLC7A11 0 0 261 261 1 2
TRIM16 PPP3CB 270 0 421 559 1 1
TRIM16 HERC6 0 0 43 254 1 1
TRIM16 WIPI2 0 0 181 197 1 2
TRIM16 OPTN 130 0 181 257 1 2
TRIM16 IFNB1 0 0 151 268 1 1
TRIM16 TEKT3 0 0 151 157 1 1
TRIM16 IRF5 0 0 90 298 1 1
TRIM16 HMGB1 0 0 0 286 1 2
TRIM16 ESR1 0 0 384 384 1 2
TRIM16 TMEM176B 0 0 134 152 1 1
TRIM16 EGF 0 0 328 328 1 2
TRIM16 CD59 0 0 47 257 1 1
TRIM16 IRF2 0 0 83 242 1 1
TRIM16 IGSF9 0 0 0 232 1 1
TRIM16 TRIM35 0 0 243 395 1 1
TRIM16 TRIM39 0 0 336 189 1 1
TRIM16 PECR 0 0 134 154 1 1
TRIM16 TRIM5 0 0 391 196 1 1
TRIM16 EPHX1 0 0 162 180 1 1
TRIM16 ATG5 0 0 193 203 1 2
TRIM16 CALCOCO2 0 0 340 349 1 2
TRIM16 C2CD4B 0 0 143 173 1 1
TRIM16 TRIM55 0 0 187 187 1 1
TRIM16 TRIM77 0 0 166 165 1 1
TRIM16 TLR8 0 0 96 253 1 1
TRIM16 ISG15 0 0 164 175 1 2
TRIM16 MAP1LC3B 0 0 203 227 1 2
TRIM16 DDRGK1 0 0 167 167 1 1
TRIM16 LYG2 0 0 0 400 1 1
TRIM16 ZNF286B 0 0 0 302 1 1
TRIM16 GLI1 0 0 142 159 1 2
TRIM16 NXT1 0 0 124 156 1 1
TRIM16 GCLC 0 0 181 181 1 1
TRIM16 VIM 270 0 0 270 1 2
TRIM16 SEC22B 0 0 578 651 1 1
TRIM16 DPYSL4 0 0 137 156 1 1
TRIM16 PLAA 0 0 145 177 1 1
TRIM16 TRIM16L 491 0 556 520 1 1
TRIM16 ULK1 270 0 262 453 1 2
TRIM16 API5 0 0 0 211 1 1
TRIM16 TCEAL5 0 0 244 243 1 1
TRIM16 TRIM26 0 0 459 517 1 1
TRIM16 TRIM54 0 0 261 261 1 1
TRIM16 AIM2 0 0 169 169 1 2
TRIM16 TRIM21 0 0 383 191 1 1
TRIM16 ZXDC 0 0 260 264 1 1
TRIM16 TRIM32 0 0 297 393 1 1
TRIM16 NAV2 0 0 108 163 1 1
TRIM16 IL10 0 0 58 181 1 2
TRIM16 TRAT1 0 0 710 714 1 1
TRIM16 ATG7 0 0 124 150 1 2
TRIM16 TRIM46 0 0 293 293 1 1
TRIM16 CUL5 270 0 59 283 1 1
TRIM16 TRIM62 0 0 234 165 1 1
TRIM16 WIPI1 0 0 95 151 1 2
TRIM16 CD276 0 0 71 361 1 1
TRIM16 RRAGB 270 0 141 346 1 1
TRIM16 TERF1 295 0 0 295 1 1
TRIM16 GPR148 0 0 181 181 1 1
TRIM16 BAIAP3 0 0 167 173 1 1
TRIM16 GOLGA6L6 0 0 163 163 1 1
TRIM16 LGALSL 0 0 167 172 1 1
TRIM16 PSMG2 0 0 63 319 1 1
TRIM16 CRABP2 0 0 67 171 1 1
TRIM16 GABARAP 0 0 693 693 1 2
TRIM16 HERC4 0 0 47 152 1 1
TRIM16 TRIM41 0 0 257 205 1 1
TRIM16 IL20 0 0 0 189 1 1
TRIM16 LGALS8 0 0 712 714 1 1
TRIM16 TRIM67 0 0 165 165 1 1
TRIM16 ALKBH7 0 0 206 217 1 1
TRIM16 CLUH 244 0 0 243 1 1
TRIM16 WT1 0 0 0 304 1 1
TRIM16 UBE2QL1 0 0 322 335 1 1
TRIM16 STX3 0 0 377 377 1 1
TRIM16 ATG12 0 0 181 181 1 2
TRIM16 ALDH3A1 0 0 160 181 1 1
TRIM16 ATG13 0 0 189 189 1 2
TRIM16 RANBP6 0 0 229 443 1 1
TRIM16 SQSTM1 0 0 324 323 1 2
TRIM16 TRIM22 0 0 415 207 1 1
TRIM16 TRIM56 0 0 370 370 1 1
TRIM16 CUL4A 270 0 61 285 1 1
TRIM16 TSPYL2 0 0 134 157 1 1
TRIM16 KEAP1 0 0 203 203 1 2
TRIM16 B2M 0 0 77 174 1 1
TRIM16 CARD16 0 0 338 338 1 1
TRIM16 POT1 295 0 0 295 1 1
TRIM16 TFEB 270 0 286 456 1 2
TRIM16 FBXO27 0 0 321 335 1 1
TRIM16 SMURF1 0 0 169 169 1 1
TRIM16 CYP26A1 0 0 231 249 1 1
TRIM16 SP100 0 0 95 151 1 1
TRIM16 NQO1 0 0 235 271 1 2
TRIM16 TRIM31 0 0 392 392 1 1
TRIM16 PKP3 0 0 92 299 1 1
TRIM16 TXNRD1 0 0 170 192 1 1
TRIM16 ATG16L1 270 0 545 653 1 2
TRIM16 TOMM34 244 0 0 243 1 1
TRIM16 LAMTOR1 0 0 155 472 1 1
TRIM16 GABARAPL1 0 0 217 217 1 2
TRIM16 TINF2 295 0 0 295 1 1
TRIM16 MID1 0 0 607 283 1 1
TRIM16 CRLF3 0 0 60 263 1 1
TRIM16 TARDBP 0 0 454 458 1 2
TRIM16 CUL3 0 0 150 154 1 2
TRIM16 CHUK 0 0 107 244 1 1
TRIM16 STX4 0 0 292 292 1 1
TRIM16 TMLHE 0 0 343 343 1 1
TRIM16 TRIM44 0 0 248 453 1 1
TRIM16 E2F1 270 0 0 270 1 2
TRIM16 MID2 0 0 406 201 1 1
TRIM16 RPP21 0 0 0 203 1 1
TRIM16 MLST8 0 0 60 301 1 1
TRIM16 TIAF1 0 0 181 181 1 1
TRIM16 CALR 0 0 49 260 1 1
TRIM16 TRIM3 0 0 407 647 1 1
TRIM16 NCKIPSD 0 0 147 171 1 1
TRIM16 NATD1 0 0 370 479 1 1
TRIM16 ATF7IP 0 0 108 311 1 1
TRIM16 IL17RA 0 0 70 445 1 1
TRIM16 SOCS3 0 0 94 168 1 1
TRIM16 SMC1A 0 0 67 201 1 1
TRIM16 AKR1C2 0 0 207 207 1 1
TRIM16 IRAK3 0 0 118 448 1 1
TRIM16 TVP23B 0 0 324 350 1 1
TRIM16 HM13 0 0 113 457 1 1
TRIM16 EPS8L2 0 0 150 154 1 1
TRIM16 DEPTOR 270 0 72 293 1 2
TRIM16 RRAGD 270 0 138 343 1 1
TRIM16 IL18R1 0 0 72 169 1 1
TRIM16 TRIM17 0 0 508 247 1 1
TRIM16 ENSG00000173366 0 0 67 203 1 1
TRIM16 RGS7BP 0 0 141 160 1 1
TRIM16 ZNF286A 0 0 0 302 1 1
TRIM16 YKT6 0 0 699 707 1 1
TRIM16 TRIM11 0 0 460 204 1 1
TRIM16 SNAP29 0 0 324 338 1 2
TRIM16 TRIM6 0 0 390 412 1 1
TRIM16 BECN1 270 0 324 491 1 2
TRIM16 TRIM64 0 0 144 176 1 1
TRIM16 DEDD 0 0 102 443 1 1
TRIM16 CASP1 0 0 381 381 1 2
TRIM16 CMYA5 0 0 171 171 1 1
TRIM16 AVPI1 0 0 210 210 1 1
TRIM16 TLR2 0 0 57 151 1 2
TRIM16 SAMD10 0 0 261 268 1 1
TRIM16 PHB 0 0 583 583 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0003677 Molecular Function DNA binding enables IDA
GO:0032089 Molecular Function NACHT domain binding enables IPI
GO:0019966 Molecular Function interleukin-1 binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0016740 Molecular Function transferase activity enables IEA
GO:0008270 Molecular Function zinc ion binding enables IEA
GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IDA
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IMP
GO:0045618 Biological Process positive regulation of keratinocyte differentiation involved_in IDA
GO:0048386 Biological Process positive regulation of retinoic acid receptor signaling pathway involved_in IDA
GO:0060416 Biological Process response to growth hormone involved_in IDA
GO:0046683 Biological Process response to organophosphorus involved_in IEP
GO:0032526 Biological Process response to retinoic acid involved_in IEP
GO:0016605 Cellular Component PML body located_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IDA
Pathways
Name DB ID
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001348121 1 mRNA transcript variant 4 NC_000017 Reference
NM_001348122 1 mRNA transcript variant 5 NC_000017 Reference
NM_001348120 1 mRNA transcript variant 2 NC_000017 Reference
NM_001348126 1 mRNA transcript variant 8 NC_000017 Reference
NM_001348124 1 mRNA transcript variant 6 NC_000017 Reference
NM_001348119 1 mRNA transcript variant 1 NC_000017 Reference
NM_001348125 1 mRNA transcript variant 7 NC_000017 Reference
NM_006470 4 mRNA transcript variant 3 NC_000017 Reference