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EBP

EBP cholestenol delta-isomerase
General Information
Name EBP cholestenol delta-isomerase
Alias
  • 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
  • 3-beta-hydroxysteroid-delta-8,delta-7-isomerase
  • Chondrodysplasia punctata-2, X-linked dominant (Happle syndrome)
  • D8-D7 sterol isomerase
  • cholestenol Delta-isomerase
  • delta(8)-Delta(7) sterol isomerase
  • emopamil binding protein (sterol isomerase)
  • emopamil-binding protein
  • sterol 8-isomerase
Gene_family
organism Homo sapiens
entrez_id 10682
location Xp11.23
transcript_count 1
exon_count 5
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]
    Stringdb 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family
    nextProt Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
EBP BioGRID Rab18 GeneID BioGRID Proximity Label-MS
EBP BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
EBP BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
EBP BioGRID RAF1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TIPARP GeneID BioGRID Affinity Capture-MS
EBP BioGRID DHCR24 GeneID BioGRID Affinity Capture-MS
EBP BioGRID OPTN GeneID BioGRID Proximity Label-MS
EBP BioGRID RB1CC1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TMEM106B GeneID BioGRID Proximity Label-MS
EBP BioGRID P2RY12 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TTYH1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID BSCL2 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TSPAN15 GeneID BioGRID Affinity Capture-MS
EBP BioGRID FZD10 GeneID BioGRID Affinity Capture-MS
EBP BioGRID CLDN19 GeneID BioGRID Affinity Capture-MS
EBP BioGRID VIPR2 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TSPAN6 GeneID BioGRID Affinity Capture-MS
EBP BioGRID SLC18A2 GeneID BioGRID Affinity Capture-MS
EBP BioGRID FFAR1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID GPR21 GeneID BioGRID Affinity Capture-MS
EBP BioGRID GPR17 GeneID BioGRID Affinity Capture-MS
EBP BioGRID KDSR GeneID BioGRID Affinity Capture-MS
EBP BioGRID EDNRA GeneID BioGRID Affinity Capture-MS
EBP BioGRID ACTA1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID GJD3 GeneID BioGRID Proximity Label-MS
EBP BioGRID PANX1 GeneID BioGRID Proximity Label-MS
EBP BioGRID RPN1 GeneID BioGRID Proximity Label-MS
EBP BioGRID ELOVL5 GeneID BioGRID Proximity Label-MS
EBP BioGRID ERGIC1 GeneID BioGRID Proximity Label-MS
EBP BioGRID HSD17B11 GeneID BioGRID Proximity Label-MS
EBP BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
EBP BioGRID HSCB GeneID BioGRID Affinity Capture-MS
EBP BioGRID TRO GeneID BioGRID Proximity Label-MS
EBP BioGRID PTK2 GeneID BioGRID Proximity Label-MS
EBP BioGRID TMEM239 GeneID BioGRID Two-hybrid
EBP BioGRID TIMM23 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM242 GeneID BioGRID Two-hybrid
EBP BioGRID SYS1 GeneID BioGRID Two-hybrid
EBP BioGRID MS4A13 GeneID BioGRID Two-hybrid
EBP BioGRID DEFB103A GeneID BioGRID Two-hybrid
EBP BioGRID PLPP6 GeneID BioGRID Two-hybrid
EBP BioGRID C4orf3 GeneID BioGRID Two-hybrid
EBP BioGRID GPR152 GeneID BioGRID Two-hybrid
EBP BioGRID C5orf46 GeneID BioGRID Two-hybrid
EBP BioGRID SNORC GeneID BioGRID Two-hybrid
EBP BioGRID LDLRAD1 GeneID BioGRID Two-hybrid
EBP BioGRID SMIM1 GeneID BioGRID Two-hybrid
EBP BioGRID SERP2 GeneID BioGRID Two-hybrid
EBP BioGRID OTOP3 GeneID BioGRID Two-hybrid
EBP BioGRID HSD17B13 GeneID BioGRID Two-hybrid
EBP BioGRID RTP2 GeneID BioGRID Two-hybrid
EBP BioGRID TRARG1 GeneID BioGRID Two-hybrid
EBP BioGRID YIPF6 GeneID BioGRID Two-hybrid
EBP BioGRID TMIE GeneID BioGRID Two-hybrid
EBP BioGRID TMEM86B GeneID BioGRID Two-hybrid
EBP BioGRID ZDHHC24 GeneID BioGRID Two-hybrid
EBP BioGRID TSPO2 GeneID BioGRID Two-hybrid
EBP BioGRID RNF152 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM218 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM31 GeneID BioGRID Two-hybrid
EBP BioGRID TSNARE1 GeneID BioGRID Two-hybrid
EBP BioGRID ARL13B GeneID BioGRID Two-hybrid
EBP BioGRID FAM209A GeneID BioGRID Two-hybrid
EBP BioGRID GIMAP1 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM229B GeneID BioGRID Two-hybrid
EBP BioGRID SLC35G1 GeneID BioGRID Two-hybrid
EBP BioGRID ANKRD46 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM65 GeneID BioGRID Two-hybrid
EBP BioGRID CCDC167 GeneID BioGRID Two-hybrid
EBP BioGRID ARL6IP6 GeneID BioGRID Two-hybrid
EBP BioGRID TLCD4 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM199 GeneID BioGRID Two-hybrid
EBP BioGRID ODF4 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM120B GeneID BioGRID Two-hybrid
EBP BioGRID TMEM86A GeneID BioGRID Two-hybrid
EBP BioGRID DEFB127 GeneID BioGRID Two-hybrid
EBP BioGRID CHODL GeneID BioGRID Two-hybrid
EBP BioGRID TMEM42 GeneID BioGRID Two-hybrid
EBP BioGRID TBC1D20 GeneID BioGRID Two-hybrid
EBP BioGRID CLDND2 GeneID BioGRID Two-hybrid
EBP BioGRID TLCD1 GeneID BioGRID Two-hybrid
EBP BioGRID SCAMP4 GeneID BioGRID Two-hybrid
EBP BioGRID STX1B GeneID BioGRID Two-hybrid
EBP BioGRID TMEM203 GeneID BioGRID Two-hybrid
EBP BioGRID ORMDL3 GeneID BioGRID Two-hybrid
EBP BioGRID ORMDL1 GeneID BioGRID Two-hybrid
EBP BioGRID SFXN5 GeneID BioGRID Two-hybrid
EBP BioGRID LEMD1 GeneID BioGRID Two-hybrid
EBP BioGRID CREB3L1 GeneID BioGRID Two-hybrid
EBP BioGRID SMIM3 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM60 GeneID BioGRID Two-hybrid
EBP BioGRID JAGN1 GeneID BioGRID Two-hybrid
EBP BioGRID DNAJC30 GeneID BioGRID Two-hybrid
EBP BioGRID YIPF4 GeneID BioGRID Two-hybrid
EBP BioGRID SLC41A2 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM222 GeneID BioGRID Two-hybrid
EBP BioGRID EMC6 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM147 GeneID BioGRID Two-hybrid
EBP BioGRID CDIPT GeneID BioGRID Two-hybrid
EBP BioGRID BTN2A2 GeneID BioGRID Two-hybrid
EBP BioGRID STX6 GeneID BioGRID Two-hybrid
EBP BioGRID C2CD2L GeneID BioGRID Two-hybrid
EBP BioGRID GOSR2 GeneID BioGRID Two-hybrid
EBP BioGRID CCL4L2 GeneID BioGRID Two-hybrid
EBP BioGRID SEC22B GeneID BioGRID Two-hybrid
EBP BioGRID STX8 GeneID BioGRID Two-hybrid
EBP BioGRID VAMP3 GeneID BioGRID Two-hybrid
EBP BioGRID VAPA GeneID BioGRID Two-hybrid
EBP BioGRID VAPB GeneID BioGRID Two-hybrid
EBP BioGRID SYNGR1 GeneID BioGRID Two-hybrid
EBP BioGRID NAT8 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM11 GeneID BioGRID Two-hybrid
EBP BioGRID VAMP4 GeneID BioGRID Two-hybrid
EBP BioGRID CYP4F2 GeneID BioGRID Two-hybrid
EBP BioGRID STX7 GeneID BioGRID Two-hybrid
EBP BioGRID ABHD16A GeneID BioGRID Two-hybrid
EBP BioGRID ZFPL1 GeneID BioGRID Two-hybrid
EBP BioGRID THBD GeneID BioGRID Two-hybrid
EBP BioGRID TMBIM6 GeneID BioGRID Two-hybrid
EBP BioGRID VAMP2 GeneID BioGRID Two-hybrid
EBP BioGRID VAMP1 GeneID BioGRID Two-hybrid
EBP BioGRID STX5 GeneID BioGRID Two-hybrid
EBP BioGRID SLC3A2 GeneID BioGRID Two-hybrid
EBP BioGRID PVR GeneID BioGRID Two-hybrid
EBP BioGRID PTPN9 GeneID BioGRID Two-hybrid
EBP BioGRID PNLIPRP1 GeneID BioGRID Two-hybrid
EBP BioGRID PMP22 GeneID BioGRID Two-hybrid
EBP BioGRID PLP2 GeneID BioGRID Two-hybrid
EBP BioGRID FXYD3 GeneID BioGRID Two-hybrid
EBP BioGRID NKG7 GeneID BioGRID Two-hybrid
EBP BioGRID NINJ2 GeneID BioGRID Two-hybrid
EBP BioGRID NINJ1 GeneID BioGRID Two-hybrid
EBP BioGRID NEU1 GeneID BioGRID Two-hybrid
EBP BioGRID NDUFA3 GeneID BioGRID Two-hybrid
EBP BioGRID MMP14 GeneID BioGRID Two-hybrid
EBP BioGRID LTC4S GeneID BioGRID Two-hybrid
EBP BioGRID HMOX2 GeneID BioGRID Two-hybrid
EBP BioGRID GJB2 GeneID BioGRID Two-hybrid
EBP BioGRID FCER1G GeneID BioGRID Two-hybrid
EBP BioGRID EMP1 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM14B GeneID BioGRID Two-hybrid
EBP BioGRID UNC93B1 GeneID BioGRID Two-hybrid
EBP BioGRID CYB5B GeneID BioGRID Two-hybrid
EBP BioGRID TMEM254 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM243 GeneID BioGRID Two-hybrid
EBP BioGRID FA2H GeneID BioGRID Two-hybrid
EBP BioGRID FUNDC2 GeneID BioGRID Two-hybrid
EBP BioGRID ARV1 GeneID BioGRID Two-hybrid
EBP BioGRID RUSF1 GeneID BioGRID Two-hybrid
EBP BioGRID SMAGP GeneID BioGRID Two-hybrid
EBP BioGRID ATP13A1 GeneID BioGRID Two-hybrid
EBP BioGRID SMCO4 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM167B GeneID BioGRID Two-hybrid
EBP BioGRID DEFB103B GeneID BioGRID Two-hybrid
EBP BioGRID USE1 GeneID BioGRID Two-hybrid
EBP BioGRID LRRC59 GeneID BioGRID Two-hybrid
EBP BioGRID GIMAP5 GeneID BioGRID Two-hybrid
EBP BioGRID SYNJ2BP GeneID BioGRID Two-hybrid
EBP BioGRID TMEM140 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM100 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM51 GeneID BioGRID Two-hybrid
EBP BioGRID LPCAT2 GeneID BioGRID Two-hybrid
EBP BioGRID MFSD6 GeneID BioGRID Two-hybrid
EBP BioGRID NDUFB11 GeneID BioGRID Two-hybrid
EBP BioGRID YIPF1 GeneID BioGRID Two-hybrid
EBP BioGRID FXYD6 GeneID BioGRID Two-hybrid
EBP BioGRID ERGIC3 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM14C GeneID BioGRID Two-hybrid
EBP BioGRID UBE2J1 GeneID BioGRID Two-hybrid
EBP BioGRID INSIG2 GeneID BioGRID Two-hybrid
EBP BioGRID IER3IP1 GeneID BioGRID Two-hybrid
EBP BioGRID PLLP GeneID BioGRID Two-hybrid
EBP BioGRID FIS1 GeneID BioGRID Two-hybrid
EBP BioGRID UBIAD1 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM208 GeneID BioGRID Two-hybrid
EBP BioGRID ORMDL2 GeneID BioGRID Two-hybrid
EBP BioGRID TMEM97 GeneID BioGRID Two-hybrid
EBP BioGRID BMP10 GeneID BioGRID Two-hybrid
EBP BioGRID SERP1 GeneID BioGRID Two-hybrid
EBP BioGRID FETUB GeneID BioGRID Two-hybrid
EBP BioGRID LRP10 GeneID BioGRID Two-hybrid
EBP BioGRID UNC50 GeneID BioGRID Two-hybrid
EBP BioGRID FKBP8 GeneID BioGRID Two-hybrid
EBP BioGRID STX12 GeneID BioGRID Two-hybrid
EBP BioGRID SACM1L GeneID BioGRID Two-hybrid
EBP BioGRID TREX1 GeneID BioGRID Two-hybrid
EBP BioGRID ERG28 GeneID BioGRID Two-hybrid
EBP BioGRID YIF1A GeneID BioGRID Two-hybrid
EBP BioGRID FAXDC2 GeneID BioGRID Two-hybrid
EBP BioGRID GJB6 GeneID BioGRID Two-hybrid
EBP BioGRID EBP GeneID BioGRID Two-hybrid
EBP BioGRID CYB561 GeneID BioGRID Two-hybrid
EBP BioGRID CD81 GeneID BioGRID Two-hybrid
EBP BioGRID CD69 GeneID BioGRID Two-hybrid
EBP BioGRID CD40 GeneID BioGRID Two-hybrid
EBP BioGRID C5 GeneID BioGRID Two-hybrid
EBP BioGRID C2 GeneID BioGRID Two-hybrid
EBP BioGRID BNIP3 GeneID BioGRID Two-hybrid
EBP BioGRID AQP6 GeneID BioGRID Two-hybrid
EBP BioGRID APP GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
EBP BioGRID OTULINL GeneID BioGRID Proximity Label-MS
EBP BioGRID VIRMA GeneID BioGRID Affinity Capture-MS
EBP BioGRID CREB3 GeneID BioGRID Two-hybrid
EBP BioGRID RNF4 GeneID BioGRID Affinity Capture-MS
EBP BioGRID GLP1R GeneID BioGRID PCA
EBP BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
EBP BioGRID ZNF598 GeneID BioGRID Affinity Capture-MS
EBP BioGRID MTNR1B GeneID BioGRID Two-hybrid
EBP BioGRID STOM GeneID BioGRID Affinity Capture-MS
EBP BioGRID HTR3A GeneID BioGRID Affinity Capture-MS
EBP BioGRID GYPB GeneID BioGRID Affinity Capture-MS
EBP BioGRID GNAI2 GeneID BioGRID Affinity Capture-MS
EBP BioGRID APLNR GeneID BioGRID Affinity Capture-MS
EBP BioGRID VIPR1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID MFSD8 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TPCN2 GeneID BioGRID Affinity Capture-MS
EBP BioGRID SLC2A12 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TM4SF20 GeneID BioGRID Affinity Capture-MS
EBP BioGRID SLC6A15 GeneID BioGRID Affinity Capture-MS
EBP BioGRID LYPD3 GeneID BioGRID Affinity Capture-MS
EBP BioGRID GPR52 GeneID BioGRID Affinity Capture-MS
EBP BioGRID REEP5 GeneID BioGRID Affinity Capture-MS
EBP BioGRID TCTN2 GeneID BioGRID Proximity Label-MS
EBP BioGRID TCTN3 GeneID BioGRID Proximity Label-MS
EBP BioGRID NCSTN GeneID BioGRID Affinity Capture-MS
EBP BioGRID SAP30 GeneID BioGRID Affinity Capture-MS
EBP BioGRID HSP90B1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID Mad2l1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID Spire2 GeneID BioGRID Affinity Capture-MS
EBP BioGRID Samm50 GeneID BioGRID Affinity Capture-MS
EBP BioGRID Tmed2 GeneID BioGRID Affinity Capture-MS
EBP BioGRID ABCE1 GeneID BioGRID Affinity Capture-MS
EBP BioGRID NXF1 GeneID BioGRID Affinity Capture-RNA
EBP BioGRID SHMT2 GeneID BioGRID Affinity Capture-RNA
EBP BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
EBP BioGRID ENO1 GeneID BioGRID Affinity Capture-RNA
EBP BioGRID MITF GeneID BioGRID Two-hybrid
EBP BioGRID VKORC1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
EBP BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
EBP BioGRID ESRRG GeneID BioGRID Two-hybrid
EBP Protein EBPL GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
EBP FA2H 114 0 107 244 1 1
EBP PCK1 0 0 134 156 1 1
EBP CYP51A1 0 0 504 619 1 1
EBP PDSS2 0 0 0 217 1 1
EBP NCSTN 168 0 0 167 1 1
EBP VAPA 73 0 90 174 1 1
EBP AOC1 0 0 0 252 1 1
EBP LBR 0 0 538 651 1 1
EBP CYP7B1 0 0 53 170 1 1
EBP GPT2 0 0 140 156 1 1
EBP APOH 0 0 134 292 1 1
EBP NPC1 0 0 187 203 1 2
EBP KRTCAP2 0 0 310 333 1 1
EBP SOAT1 0 0 149 168 1 1
EBP KIFC1 0 0 347 377 1 1
EBP C12orf10 0 0 0 183 1 1
EBP GPR21 186 0 0 186 1 1
EBP CH25H 0 0 82 174 1 1
EBP SPEG 0 0 181 181 1 1
EBP ARSD 0 0 389 388 1 1
EBP OSBPL5 0 0 155 154 1 1
EBP KHDC1 0 0 203 203 1 1
EBP MRPL13 0 0 0 150 1 1
EBP DCN 0 0 242 250 1 2
EBP EBPL 213 0 230 254 1 1
EBP INSIG1 0 0 304 393 1 1
EBP SHOX 0 0 304 304 1 1
EBP HMBS 0 0 43 163 1 1
EBP HMGCS1 0 0 413 676 1 1
EBP ADAT2 0 0 137 175 1 1
EBP VKORC1L1 0 0 210 220 1 1
EBP EXO1 0 0 0 156 1 1
EBP TIMM23 118 0 0 163 1 1
EBP GABRA3 0 0 490 489 1 1
EBP PLEKHA8 0 0 170 169 1 1
EBP HSCB 270 0 0 288 1 1
EBP PIGK 0 0 202 202 1 1
EBP TBCD 0 0 143 228 1 1
EBP PMVK 0 0 418 490 1 1
EBP PIGN 0 0 171 171 1 1
EBP KIAA1429 270 0 0 270 1 1
EBP DDOST 0 0 108 191 1 1
EBP SYNDIG1 0 0 181 210 1 1
EBP DHCR7 0 0 729 813 1 1
EBP MSI1 0 0 0 555 1 1
EBP APP 192 0 0 192 1 2
EBP MRPL12 0 0 0 151 1 1
EBP TAMM41 0 0 359 359 1 1
EBP SHKBP1 0 0 194 194 1 1
EBP DPM2 0 0 150 171 1 1
EBP LYPD3 129 0 55 228 1 1
EBP KHDRBS1 0 0 0 158 1 1
EBP GCSH 0 0 150 186 1 1
EBP HSD17B7 0 900 375 939 1 1
EBP HSD11B1 0 0 91 255 1 1
EBP ELOVL2 0 0 168 186 1 1
EBP SC5D 0 900 813 983 1 1
EBP ZNF285 0 0 170 169 1 1
EBP AOC3 0 0 45 607 1 1
EBP SLC31A2 0 0 195 195 1 1
EBP ACSS2 0 0 155 260 1 1
EBP ART5 0 0 187 187 1 1
EBP HPS6 0 0 0 153 1 1
EBP KHDRBS2 0 0 0 158 1 1
EBP SLC18A3 0 0 162 161 1 1
EBP TM7SF2 0 900 721 978 1 1
EBP CYP39A1 0 0 45 163 1 1
EBP TMBIM4 0 0 246 262 1 1
EBP ELOVL5 0 0 135 153 1 1
EBP IDI2 0 0 156 214 1 1
EBP KIAA0226L 0 0 66 212 1 1
EBP CYP7A1 0 0 74 188 1 1
EBP OOEP 0 0 69 158 1 1
EBP TMED3 0 0 160 159 1 1
EBP FUZ 0 0 167 167 1 1
EBP IRF6 0 0 145 294 1 1
EBP PEMT 0 0 459 513 1 1
EBP P2RY12 195 0 0 195 1 1
EBP EXO5 0 0 218 218 1 1
EBP ATAD2 0 0 96 199 1 1
EBP FDPS 0 0 470 598 1 1
EBP NDUFA3 111 0 143 237 1 1
EBP INSIG2 77 0 173 254 1 1
EBP ABCG4 0 0 74 188 1 1
EBP ARSE 0 0 764 764 1 1
EBP SGMS1 0 0 125 218 1 1
EBP PCDH19 0 0 629 629 1 1
EBP HSD3B1 0 0 262 359 1 1
EBP METTL7A 0 0 170 209 1 1
EBP MAT2B 0 0 0 168 1 1
EBP TOMM40 0 0 47 151 1 1
EBP IER3IP1 75 0 315 339 1 1
EBP NDUFAF6 0 0 0 223 1 1
EBP ACTR5 0 0 172 171 1 1
EBP KIFC2 0 0 315 330 1 1
EBP ABCG1 0 0 90 166 1 2
EBP STARD4 0 0 275 409 1 1
EBP MSMO1 0 0 558 674 1 1
EBP GLP1R 191 0 0 191 1 1
EBP UGCG 0 0 134 160 1 1
EBP NENF 0 0 0 256 1 1
EBP ACAA2 0 0 0 182 1 1
EBP CTNS 0 0 0 210 1 2
EBP FTSJ1 0 0 0 319 1 1
EBP REEP5 131 0 0 151 1 1
EBP EPB41L4B 0 0 161 161 1 1
EBP NUMB 0 0 0 303 1 1
EBP PGRMC2 0 0 0 256 1 1
EBP SCARB1 0 0 109 164 1 1
EBP RIC1 0 0 203 203 1 1
EBP EMC6 114 0 82 176 1 1
EBP NSDHL 0 0 826 940 1 1
EBP HMGCS2 0 0 119 352 1 1
EBP PEX5L 0 0 167 519 1 1
EBP ACAA1 0 0 0 163 1 1
EBP SDR42E1 0 0 0 168 1 1
EBP LGALS4 0 0 167 177 1 1
EBP PDSS1 0 0 134 300 1 1
EBP ZNF148 0 0 0 248 1 1
EBP GLUD1 0 0 161 167 1 1
EBP ZDHHC3 0 0 0 186 1 1
EBP PAK3 0 0 156 155 1 1
EBP HSDL2 0 0 181 262 1 1
EBP PEX5 0 0 0 204 1 1
EBP PTGIS 0 0 0 159 1 1
EBP FASN 0 0 218 218 1 2
EBP MRPL3 0 0 0 183 1 1
EBP HSD17B13 116 0 60 154 1 1
EBP SQLE 0 0 451 542 1 1
EBP YIPF6 75 0 285 310 1 1
EBP CYCS 0 0 60 174 1 2
EBP ARSF 0 0 384 384 1 1
EBP NUCB2 0 0 134 358 1 1
EBP GNPAT 0 0 357 357 1 1
EBP HSP90B1 128 0 0 165 1 1
EBP KCNH6 0 0 720 720 1 1
EBP KHDRBS3 0 0 119 433 1 1
EBP PPIB 0 0 118 173 1 1
EBP PGRMC1 0 0 57 268 1 1
EBP FAXDC2 94 0 0 410 1 1
EBP PSD2 0 0 288 288 1 1
EBP RNF4 270 0 0 270 1 1
EBP GGPS1 0 0 426 503 1 1
EBP PON3 0 0 181 336 1 1
EBP TMEM147 75 0 380 460 1 1
EBP SRSF4 0 0 112 205 1 1
EBP NFAT5 0 0 0 167 1 1
EBP VWF 0 0 46 193 1 1
EBP CYB5R3 0 0 122 177 1 1
EBP KIFC3 0 0 159 177 1 1
EBP BCAP31 0 0 372 402 1 1
EBP DPM3 0 0 294 304 1 1
EBP KHDC3L 0 0 61 208 1 1
EBP LIPG 0 0 134 157 1 1
EBP NDUFV1 0 0 0 214 1 1
EBP LIPA 0 0 217 217 1 1
EBP EDNRA 283 0 0 282 1 1
EBP HMGCR 0 0 325 467 1 1
EBP AOC2 0 0 0 181 1 1
EBP PCYT1B 0 0 205 222 1 1
EBP TMEM97 63 0 166 215 1 1
EBP IPPK 0 0 193 193 1 1
EBP STAR 0 0 213 213 1 1
EBP SAP30 198 0 0 198 1 1
EBP LRGUK 0 0 0 165 1 1
EBP SREBF2 0 0 220 249 1 1
EBP MSI2 0 0 0 555 1 1
EBP VPRBP 0 0 0 154 1 1
EBP PSD 0 0 469 469 1 1
EBP MALL 0 0 170 169 1 1
EBP PGS1 0 0 250 250 1 1
EBP SLC39A13 0 0 218 218 1 1
EBP DHRS3 0 0 101 154 1 1
EBP BCL2 0 0 66 277 1 2
EBP FDFT1 0 0 465 624 1 1
EBP ACOT8 0 0 202 202 1 1
EBP KIF23 0 0 603 615 1 1
EBP AHCTF1 0 0 127 261 1 1
EBP CDIPT 79 0 217 267 1 1
EBP FADS1 0 0 643 677 1 1
EBP FADS2 0 0 178 211 1 1
EBP ACAT1 0 0 325 525 1 1
EBP GLB1L 0 0 0 189 1 1
EBP UBB 0 0 163 163 1 1
EBP HSD17B12 0 0 145 202 1 1
EBP AP1S3 0 0 0 189 1 1
EBP HIAT1 0 0 85 184 1 1
EBP SPINT2 0 0 172 171 1 1
EBP DHCR24 0 900 526 961 1 1
EBP HSD3B7 0 0 277 372 1 1
EBP TM6SF2 0 0 261 261 1 1
EBP HSD17B8 0 0 141 240 1 1
EBP SCD 0 0 234 367 1 1
EBP ABCD2 0 0 162 161 1 1
EBP COASY 0 0 188 188 1 1
EBP MVD 0 0 394 552 1 1
EBP IDI1 0 0 413 524 1 1
EBP ACLY 0 0 163 213 1 1
EBP PHGDH 0 0 210 210 1 1
EBP FDX1 0 0 247 314 1 1
EBP DPH5 0 0 0 165 1 1
EBP GBAS 0 0 166 227 1 1
EBP TMED5 0 0 194 194 1 1
EBP ATP10D 0 0 193 210 1 1
EBP CNIH4 0 0 235 235 1 1
EBP CYP8B1 0 0 49 166 1 1
EBP EMC10 0 0 266 266 1 1
EBP ATP7A 0 0 0 180 1 1
EBP DAD1 0 0 96 162 1 1
EBP SLC41A1 0 0 170 189 1 1
EBP SIGMAR1 0 0 285 359 1 1
EBP SRD5A1 0 0 0 222 1 1
EBP NHP2 0 0 0 196 1 1
EBP SCD5 0 0 0 189 1 1
EBP BGN 0 0 572 576 1 1
EBP LRRK2 270 0 0 278 1 2
EBP ADHFE1 0 0 146 438 1 1
EBP STT3A 0 0 115 154 1 1
EBP C14orf1 76 0 406 526 1 1
EBP TKT 0 0 193 193 1 1
EBP SLC35B1 0 0 306 321 1 1
EBP PDE6A 0 0 113 168 1 1
EBP ME3 0 0 141 156 1 1
EBP PISD 0 0 242 241 1 1
EBP ZNF598 270 0 172 384 1 1
EBP ACAT2 0 0 456 686 1 1
EBP FBP1 0 0 157 156 1 1
EBP IDS 0 0 150 208 1 1
EBP SMPD1 0 0 167 186 1 1
EBP SGMS2 0 0 123 319 1 1
EBP CA11 0 0 255 254 1 1
EBP PNPLA3 0 0 120 159 1 1
EBP ADCK1 0 0 82 223 1 1
EBP MTCH2 0 0 184 213 1 1
EBP ISYNA1 0 0 518 518 1 1
EBP CYP46A1 0 0 156 339 1 1
EBP LIPC 0 0 73 313 1 1
EBP PANK3 0 0 161 202 1 1
EBP TMEM208 94 0 0 165 1 1
EBP DBI 0 0 123 175 1 1
EBP GPR52 271 0 0 271 1 1
EBP SREBF1 0 0 164 177 1 1
EBP MRPL21 0 0 0 191 1 1
EBP RAB27B 0 0 0 245 1 1
EBP ATP7B 0 0 94 249 1 1
EBP HSD3B2 0 0 112 229 1 1
EBP SUGCT 0 0 143 161 1 1
EBP SDR42E2 0 0 0 168 1 1
EBP RCL1 0 0 286 286 1 1
EBP ABCE1 270 0 0 270 1 1
EBP CXCL2 0 0 308 307 1 1
EBP ST5 0 0 47 213 1 1
EBP ZFPL1 63 0 66 183 1 1
EBP MRPL17 0 0 0 196 1 1
EBP DLEU7 0 0 0 303 1 1
EBP HADHB 0 0 0 163 1 1
EBP CHST6 0 0 171 171 1 1
EBP ZCCHC17 0 0 113 421 1 1
EBP LSS 0 0 556 661 1 1
EBP ISG15 270 0 0 270 1 2
EBP GLYCTK 0 0 205 205 1 1
EBP PAG1 0 0 398 398 1 1
EBP NUCB1 0 0 58 193 1 1
EBP ODF1 0 0 45 175 1 1
EBP MFSD8 214 0 0 214 1 1
EBP DPM1 0 0 218 233 1 1
EBP ACADS 0 0 96 223 1 1
EBP PTDSS2 0 0 194 194 1 1
EBP OSBP 0 0 204 204 1 1
EBP EMC7 0 0 360 360 1 1
EBP WLS 500 0 0 499 1 1
EBP MVK 0 0 391 536 1 1
EBP KSR1 270 0 0 270 1 1
EBP PCCB 0 0 180 200 1 1
EBP SRD5A2 0 0 0 222 1 1
EBP RDH11 0 0 138 187 1 1
EBP F9 0 0 293 304 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0000247 Molecular Function C-8 sterol isomerase activity enables IBA
GO:0000247 Molecular Function C-8 sterol isomerase activity enables ISS
GO:0047750 Molecular Function cholestenol delta-isomerase activity enables IEA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0004769 Molecular Function steroid delta-isomerase activity enables EXP
GO:0004769 Molecular Function steroid delta-isomerase activity enables IBA
GO:0004769 Molecular Function steroid delta-isomerase activity enables IDA
GO:0004769 Molecular Function steroid delta-isomerase activity enables IMP
GO:0006695 Biological Process cholesterol biosynthetic process involved_in IBA
GO:0006695 Biological Process cholesterol biosynthetic process involved_in IDA
GO:0033489 Biological Process cholesterol biosynthetic process via desmosterol involved_in TAS
GO:0033490 Biological Process cholesterol biosynthetic process via lathosterol involved_in TAS
GO:0008203 Biological Process cholesterol metabolic process involved_in IMP
GO:0030097 Biological Process hemopoiesis involved_in IEA
GO:0043931 Biological Process ossification involved in bone maturation involved_in IMP
GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
GO:0005783 Cellular Component endoplasmic reticulum is_active_in IBA
GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in ISM
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in TAS
GO:0005635 Cellular Component nuclear envelope located_in IDA
GO:0031965 Cellular Component nuclear membrane located_in IDA
Pathways
Name DB ID
Metabolism Reactome R-HSA-1430728
Cholesterol biosynthesis Reactome R-HSA-191273
Metabolism of lipids Reactome R-HSA-556833
Cholesterol biosynthesis via desmosterol Reactome R-HSA-6807047
Cholesterol biosynthesis via lathosterol Reactome R-HSA-6807062
Metabolism of steroids Reactome R-HSA-8957322
Cholesterol metabolism with Bloch and Kandutsch-Russell pathways (WP4718) WikiPathways WP4718_r124755
7-oxo-C and 7-beta-HC pathways (WP5064) WikiPathways WP5064_r120384
Cholesterol synthesis disorders (WP5193) WikiPathways WP5193_r122440
Cholesterol biosynthesis with skeletal dysplasias (WP4804) WikiPathways WP4804_r117680
Oxysterols derived from cholesterol (WP4545) WikiPathways WP4545_r123863
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_006579 3 mRNA None NC_000023 Reference