HAdb 2.0 is available now!

KCNQ1OT1

KCNQ1 opposite strand/antisense transcript 1
General Information
Name KCNQ1 opposite strand/antisense transcript 1
Alias
  • KCNQ1 antisense RNA 2 (non-protein coding)
  • KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
  • KCNQ1 overlapping transcript 1 (non-protein coding)
  • long QT intronic transcript 1
Gene_family Long non-coding RNAs with non-systematic symbols
organism Homo sapiens
entrez_id 10984
location 11p15.5
transcript_count 1
exon_count 1
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Human chromosomal region 11p15.5 contains two clusters of epigenetically-regulated genes that are expressed from only one chromosome in a parent-of-origin manner. Each cluster, or imprinted domain, is regulated by a functionally independent imprinting control region (ICR). The human CDKN1C/KCNQ1OT1 domain is regulated by an ICR located in an intron of KCNQ1, and contains at least eight genes that are expressed exclusively or preferentially from the maternally-inherited allele. The DNA of the ICR is specifically methylated on the maternally-inherited chromosome, and unmethylated on the paternally-inherited chromosome. The ICR contains the promoter of the KCNQ1OT1 gene that is exclusively expressed from the paternal allele. The KCNQ1OT1 transcript is the antisense to the KCNQ1 gene and is a unspliced long non-coding RNA. It interacts with chromatin and regulates transcription of multiple target genes through epigenetic modifications. The transcript is abnormally expressed from both chromosomes in most patients with Beckwith-Wiedemann syndrome, and the transcript also plays an important role in colorectal carcinogenesis. [provided by RefSeq, Apr 2012]
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
KCNQ1OT1 BioGRID HK2 GeneID BioGRID Affinity Capture-RNA
StringDB
A B experiments database textmining combined score hadb nhadb
Ontologies
ID Category Term Effect Evidence PubMed
GO:0035198 Molecular Function miRNA binding enables IDA
GO:0035198 Molecular Function miRNA binding enables IMP
GO:0140869 Molecular Function miRNA inhibitor activity via base-pairing enables IDA
GO:0140869 Molecular Function miRNA inhibitor activity via base-pairing enables IMP
GO:0031507 Biological Process heterochromatin formation involved_in IEA
GO:0000512 Biological Process lncRNA-mediated post-transcriptional gene silencing involved_in IDA
GO:0000512 Biological Process lncRNA-mediated post-transcriptional gene silencing involved_in IMP
GO:0001649 Biological Process osteoblast differentiation acts_upstream_of IMP
GO:0030513 Biological Process positive regulation of BMP signaling pathway acts_upstream_of IMP
GO:0001819 Biological Process positive regulation of cytokine production acts_upstream_of IMP
GO:0010628 Biological Process positive regulation of gene expression involved_in IGI
GO:0010628 Biological Process positive regulation of gene expression acts_upstream_of IMP
GO:2000627 Biological Process positive regulation of miRNA catabolic process involved_in IDA
GO:2000627 Biological Process positive regulation of miRNA catabolic process involved_in IGI
GO:2000627 Biological Process positive regulation of miRNA catabolic process involved_in IMP
GO:0045669 Biological Process positive regulation of osteoblast differentiation involved_in IDA
GO:0005730 Cellular Component nucleolus located_in IEA
Pathways
Name DB ID
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_002728 4 ncRNA None NC_000011 Reference