IL24

interleukin 24
General Information
Name interleukin 24
Alias
  • interleukin-24
  • IL-4-induced secreted protein
  • melanocyte-associated Mda-7
  • melanoma differentiation-associated gene 7 protein
  • suppression of tumorigenicity 16 (melanoma differentiation)
Synonyms mda-7 IL10B Mob-5 C49A FISP IL-24 MDA7 MOB5 ST16
Gene_family Interleukins
organism Homo sapiens
entrez_id 11009
location 1q32.1
transcript_count 7
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
      Stringdb Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family
      nextProt Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I intereferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    IL24 BioGRID S100A6 GeneID BioGRID Reconstituted Complex
    IL24 BioGRID S100P GeneID BioGRID Reconstituted Complex
    IL24 BioGRID EIF2AK2 GeneID BioGRID Affinity Capture-Western
    IL24 BioGRID UBE3A GeneID BioGRID Two-hybrid
    IL24 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
    IL24 BioGRID CTBP2 GeneID BioGRID Affinity Capture-MS
    IL24 BioGRID RIPK3 GeneID BioGRID Reconstituted Complex
    IL24 BioGRID Eea1 GeneID BioGRID Affinity Capture-MS
    IL24 BioGRID Racgap1 GeneID BioGRID Affinity Capture-MS
    IL24 BioGRID PALB2 GeneID BioGRID Two-hybrid
    IL24 BioGRID FBXW7 GeneID BioGRID Two-hybrid
    IL24 BioGRID CHEK2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IL24 BioGRID RB1CC1 GeneID BioGRID Two-hybrid
    IL24 BioGRID BAG4 GeneID BioGRID Two-hybrid
    IL24 BioGRID HMMR GeneID BioGRID Two-hybrid
    IL24 BioGRID ESR2 GeneID BioGRID Two-hybrid
    IL24 BioGRID CASP8 GeneID BioGRID Two-hybrid
    IL24 BioGRID ATM GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IL24 BioGRID APC GeneID BioGRID Two-hybrid
    IL24 BioGRID AKT1 GeneID BioGRID Two-hybrid
    IL24 BioGRID PARP1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IL24 BioGRID RAD51 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IL24 BioGRID PTEN GeneID BioGRID Two-hybrid
    IL24 BioGRID PIK3CA GeneID BioGRID Two-hybrid
    IL24 BioGRID NOTCH2 GeneID BioGRID Two-hybrid
    IL24 BioGRID SMAD4 GeneID BioGRID Two-hybrid
    IL24 BioGRID LSP1 GeneID BioGRID Two-hybrid
    IL24 BioGRID KRAS GeneID BioGRID Two-hybrid
    IL24 BioGRID HRAS GeneID BioGRID Two-hybrid
    IL24 BioGRID DCD GeneID BioGRID Two-hybrid
    IL24 BioGRID RARG GeneID BioGRID Two-hybrid
    IL24 BioGRID CCR5 GeneID BioGRID Two-hybrid
    IL24 BioGRID CLU GeneID BioGRID Reconstituted Complex
    IL24 Protein IL20RA GeneID HPRD None
    StringDB
    A B experiments database textmining combined score hadb nhadb
    IL24 PTEN 63 0 218 235 1 2
    IL24 STX11 0 0 0 150 1 1
    IL24 IL20 0 800 0 819 1 1
    IL24 IL17RE 0 0 120 175 1 1
    IL24 IRF4 0 0 167 216 1 1
    IL24 FSD1L 0 0 134 225 1 1
    IL24 KRT16 0 0 217 217 1 1
    IL24 VEGFA 0 0 377 377 1 1
    IL24 GLIPR1 0 0 112 517 1 1
    IL24 COX20 0 0 95 235 1 1
    IL24 ALB 0 0 170 169 1 1
    IL24 CASP8 59 0 294 328 1 2
    IL24 SSSCA1 0 0 125 260 1 1
    IL24 CNTFR 0 600 67 610 1 1
    IL24 SLITRK4 0 0 81 183 1 1
    IL24 PRSS27 0 0 116 176 1 1
    IL24 CCL2 0 0 318 317 1 2
    IL24 IFNE 0 0 162 196 1 1
    IL24 LEPR 0 600 0 600 1 1
    IL24 IL16 0 0 263 306 1 1
    IL24 IFI6 0 0 150 196 1 1
    IL24 IFI44L 0 0 95 151 1 1
    IL24 CNTF 0 0 169 169 1 1
    IL24 TNFRSF10A 0 0 125 166 1 1
    IL24 IL17F 0 0 369 384 1 1
    IL24 BIRC3 0 0 83 167 1 1
    IL24 IL9 0 0 370 384 1 1
    IL24 CD79A 0 0 0 181 1 1
    IL24 IL27 0 0 170 274 1 1
    IL24 MSRB2 0 0 47 191 1 1
    IL24 FCGR2A 0 0 138 163 1 1
    IL24 IL4 0 0 454 454 1 1
    IL24 ARTN 0 0 183 183 1 1
    IL24 CSF3R 0 600 95 622 1 1
    IL24 IL21R 0 600 202 679 1 1
    IL24 PDGFRB 0 600 60 607 1 1
    IL24 ARMCX4 0 0 235 235 1 1
    IL24 IL18RAP 0 0 96 178 1 1
    IL24 DEFB4B 0 0 209 209 1 1
    IL24 CDH1 0 0 234 234 1 1
    IL24 IL17RD 0 0 95 157 1 1
    IL24 PDGFRA 0 600 0 600 1 1
    IL24 GPR157 0 0 96 152 1 1
    IL24 IL23A 0 0 180 228 1 1
    IL24 CCL3 0 0 210 248 1 1
    IL24 LALBA 0 0 74 274 1 1
    IL24 CCL22 0 0 160 160 1 1
    IL24 HYOU1 0 0 288 316 1 1
    IL24 FXYD4 0 0 82 174 1 1
    IL24 CCL4 0 0 160 209 1 1
    IL24 DGKI 0 0 61 201 1 1
    IL24 IL1A 0 0 455 471 1 1
    IL24 DAPK2 0 0 45 153 1 2
    IL24 FCAMR 0 0 268 335 1 1
    IL24 APOBEC1 0 0 0 173 1 1
    IL24 CXCL2 0 0 294 294 1 1
    IL24 IL10 0 0 681 708 1 1
    IL24 CCL20 0 0 372 408 1 1
    IL24 PRF1 0 0 156 199 1 1
    IL24 IL2RG 0 600 108 666 1 1
    IL24 NCF2 0 0 0 151 1 1
    IL24 CISH 0 0 233 258 1 1
    IL24 CRHR2 0 0 155 154 1 1
    IL24 TERT 0 0 134 157 1 1
    IL24 DAPK3 0 0 0 183 1 2
    IL24 IL22RA1 800 800 951 997 1 1
    IL24 FLG 0 0 213 213 1 1
    IL24 FAM178A 0 0 162 161 1 1
    IL24 DEFB113 0 0 50 218 1 1
    IL24 SLC15A3 0 0 52 245 1 1
    IL24 NRTN 0 0 184 183 1 1
    IL24 WDFY4 0 0 62 178 1 1
    IL24 GCC1 0 0 0 231 1 1
    IL24 IL1F10 0 0 180 179 1 1
    IL24 CD300LB 0 0 85 163 1 1
    IL24 TBX21 0 0 167 252 1 1
    IL24 IL5RA 0 600 74 619 1 1
    IL24 MAPK8 0 0 235 235 1 2
    IL24 GNPTAB 0 0 155 154 1 1
    IL24 ADK 0 0 133 330 1 1
    IL24 FN1 0 0 194 194 1 1
    IL24 VTN 0 0 329 329 1 1
    IL24 CCR7 0 0 113 333 1 1
    IL24 IL10RB 0 600 606 837 1 1
    IL24 PTCHD2 0 0 81 183 1 1
    IL24 ST8SIA2 0 0 159 219 1 1
    IL24 CXCL17 0 0 181 181 1 1
    IL24 ETS1 0 0 144 205 1 1
    IL24 MCL1 0 0 381 381 1 2
    IL24 IL17A 0 0 469 482 1 1
    IL24 CTSB 0 0 143 176 1 2
    IL24 GCC2 0 0 0 212 1 1
    IL24 SRRM1 0 0 51 196 1 1
    IL24 EGF 0 0 218 258 1 1
    IL24 CYCS 0 0 216 216 1 1
    IL24 GADD45B 0 0 134 151 1 1
    IL24 TLR7 0 0 134 155 1 1
    IL24 CXCL11 0 0 256 264 1 1
    IL24 IL13RA2 0 600 161 650 1 1
    IL24 IFNB1 0 0 421 444 1 1
    IL24 CASP9 0 0 284 284 1 1
    IL24 ITGAM 0 0 142 184 1 1
    IL24 TLR8 0 0 134 185 1 1
    IL24 DEFB103B 0 0 193 193 1 1
    IL24 NFYA 0 0 0 173 1 1
    IL24 CXCL9 0 0 207 226 1 1
    IL24 CAMTA2 0 0 74 237 1 1
    IL24 ANO9 0 0 84 183 1 1
    IL24 ATG5 0 0 233 232 1 2
    IL24 HSP90B1 0 0 213 213 1 1
    IL24 PPT1 0 0 293 293 1 1
    IL24 CCR2 0 0 151 192 1 2
    IL24 EBI3 0 0 180 204 1 1
    IL24 MPL 0 600 0 600 1 1
    IL24 EAF2 0 0 87 185 1 1
    IL24 IL12RB2 0 600 107 627 1 1
    IL24 IRF1 0 0 219 262 1 1
    IL24 STAT2 0 0 181 181 1 1
    IL24 HSPA4 0 0 166 165 1 1
    IL24 CXCR3 0 0 118 170 1 1
    IL24 IRF2 0 0 150 151 1 1
    IL24 XBP1 0 0 165 165 1 2
    IL24 TYK2 0 0 285 284 1 1
    IL24 SIGMAR1 0 0 537 537 1 1
    IL24 BATF 0 0 161 229 1 1
    IL24 JUN 0 0 320 319 1 1
    IL24 CCL24 0 0 142 184 1 1
    IL24 IFNA13 0 0 159 158 1 1
    IL24 S1PR4 0 0 0 151 1 1
    IL24 SERPINB2 0 0 134 177 1 1
    IL24 BCL2L11 0 0 210 210 1 1
    IL24 CD86 0 0 164 213 1 1
    IL24 IL10RA 0 600 469 810 1 1
    IL24 GZMA 0 0 124 166 1 1
    IL24 IL18R1 0 0 265 291 1 1
    IL24 PHB 0 0 0 189 1 1
    IL24 USP35 0 0 0 252 1 1
    IL24 GPR83 0 0 105 264 1 1
    IL24 JAK3 0 0 171 195 1 1
    IL24 PMAIP1 0 0 134 155 1 1
    IL24 TNFSF10 0 0 252 270 1 2
    IL24 TLR2 0 0 218 246 1 1
    IL24 CERS6 0 0 307 387 1 1
    IL24 COL18A1 0 0 184 183 1 1
    IL24 PHF12 0 0 49 218 1 1
    IL24 TK1 0 0 57 297 1 1
    IL24 CASP1 0 0 96 194 1 2
    IL24 IL2 0 0 421 420 1 1
    IL24 MSMB 0 0 139 230 1 1
    IL24 EVI2B 0 0 0 152 1 1
    IL24 CD27 0 0 224 273 1 1
    IL24 THBS1 0 0 108 163 1 1
    IL24 CD74 0 0 112 164 1 1
    IL24 CYB5R4 0 0 76 158 1 1
    IL24 DNTT 0 0 150 181 1 1
    IL24 CCL7 0 0 235 251 1 1
    IL24 BECN1 270 0 530 642 1 2
    IL24 CXCL6 0 0 202 202 1 1
    IL24 MMP2 0 0 234 234 1 1
    IL24 RUNX3 0 0 71 154 1 1
    IL24 SLAMF1 0 0 54 180 1 1
    IL24 CD3E 0 0 90 170 1 1
    IL24 IFNGR1 0 600 194 664 1 1
    IL24 IL22RA2 0 600 464 776 1 1
    IL24 ITGB2 0 0 61 156 1 1
    IL24 TAF12 0 0 0 221 1 1
    IL24 KRAS 59 0 218 246 1 1
    IL24 CNR2 0 0 150 211 1 1
    IL24 ADAM8 0 0 46 239 1 1
    IL24 CD8A 0 0 335 354 1 1
    IL24 ENSG00000279508 0 0 242 241 1 1
    IL24 COX18 0 0 87 423 1 1
    IL24 CD96 0 0 42 218 1 1
    IL24 HSPA5 0 0 930 930 1 2
    IL24 FCRLA 0 0 0 181 1 1
    IL24 EIF2AK2 0 0 134 217 1 2
    IL24 PRR22 0 0 195 195 1 1
    IL24 IFNL3 0 0 469 469 1 1
    IL24 XAF1 0 0 134 188 1 1
    IL24 IL7R 0 600 202 711 1 1
    IL24 IL36RN 0 0 287 286 1 1
    IL24 NCOA4 0 0 161 161 1 1
    IL24 CCR5 111 0 120 224 1 1
    IL24 IL37 0 0 294 294 1 1
    IL24 CD69 0 0 107 161 1 1
    IL24 LTA 0 0 166 244 1 1
    IL24 STAT5A 0 0 256 292 1 1
    IL24 IL31 0 0 391 390 1 1
    IL24 IFNK 0 0 204 236 1 1
    IL24 MATK 0 0 155 215 1 1
    IL24 IL17RA 0 0 201 201 1 1
    IL24 SOCS3 0 0 286 303 1 1
    IL24 CCRL2 0 0 170 212 1 1
    IL24 IL15RA 0 0 151 198 1 1
    IL24 SV2A 0 0 0 302 1 1
    IL24 FOS 0 0 170 169 1 1
    IL24 FASLG 0 0 261 261 1 1
    IL24 S100A8 0 0 87 174 1 1
    IL24 CCL27 0 0 130 166 1 1
    IL24 CD24 0 0 172 171 1 1
    IL24 MSRB1 0 0 0 186 1 1
    IL24 MS4A1 0 0 0 194 1 1
    IL24 IL22 0 0 602 618 1 1
    IL24 CSF1 0 0 167 167 1 1
    IL24 ICAM1 0 0 160 209 1 1
    IL24 CEBPB 0 0 143 168 1 1
    IL24 SMPD1 0 0 180 186 1 1
    IL24 IL13RA1 0 600 69 611 1 1
    IL24 TG 0 0 100 196 1 1
    IL24 CCDC80 0 0 53 154 1 1
    IL24 GHR 0 600 0 600 1 1
    IL24 FAM3D 0 0 92 166 1 1
    IL24 NOD2 0 0 95 168 1 1
    IL24 PTPRC 0 0 142 200 1 1
    IL24 PIGR 0 0 180 179 1 1
    IL24 TMEM131 0 0 243 414 1 1
    IL24 S100A12 0 0 212 244 1 1
    IL24 CRLF2 0 600 61 608 1 1
    IL24 STX1A 0 0 113 206 1 1
    IL24 CXCL12 0 0 160 159 1 1
    IL24 RBL2 0 0 54 437 1 1
    IL24 PI16 0 0 0 248 1 1
    IL24 TULP3 0 0 0 188 1 1
    IL24 GPR29 0 0 163 163 1 1
    IL24 ZNF740 0 0 63 161 1 1
    IL24 IL36A 0 0 261 261 1 1
    IL24 ST14 0 0 247 256 1 1
    IL24 NR1D2 0 0 0 189 1 1
    IL24 BLK 0 0 0 151 1 1
    IL24 SPP1 0 0 139 276 1 1
    IL24 ITGAX 0 0 139 167 1 1
    IL24 CDKN1A 0 0 139 171 1 2
    IL24 SOCS2 0 0 150 239 1 1
    IL24 IFNAR2 0 600 185 667 1 1
    IL24 CXCL16 0 0 112 185 1 1
    IL24 CDKN2A 0 0 181 181 1 2
    IL24 CASP4 0 0 94 162 1 2
    IL24 CD1C 0 0 101 186 1 1
    IL24 CXCL5 0 0 281 281 1 1
    IL24 B2M 0 0 96 161 1 1
    IL24 MMP9 0 0 241 278 1 1
    IL24 MAPK3 0 0 216 216 1 2
    IL24 IGSF10 0 0 202 202 1 1
    IL24 FCGR2B 0 0 107 160 1 1
    IL24 HMCN2 0 0 92 184 1 1
    IL24 CD5 0 0 240 318 1 1
    IL24 CD28 0 0 198 236 1 1
    IL24 IL17B 0 0 384 406 1 1
    IL24 TNFRSF10B 0 0 170 227 1 1
    IL24 IL13 0 0 414 414 1 1
    IL24 ACTB 0 0 282 282 1 1
    IL24 CD40 0 0 255 276 1 1
    IL24 PPM1B 0 0 49 195 1 1
    IL24 ACE 0 0 67 228 1 1
    IL24 EPRS 0 0 51 150 1 1
    IL24 TNFSF13B 0 0 167 167 1 1
    IL24 SELL 0 0 109 200 1 1
    IL24 CYP26A1 0 0 71 164 1 1
    IL24 PTGS2 0 0 283 309 1 1
    IL24 XCL2 0 0 157 201 1 1
    IL24 CASP3 0 0 374 374 1 2
    IL24 TUB 0 0 0 258 1 1
    IL24 IL1RL1 0 0 195 195 1 1
    IL24 HEPHL1 0 0 93 190 1 1
    IL24 IL3 0 0 242 241 1 1
    IL24 LTB 0 0 112 199 1 1
    IL24 CXCL1 0 0 324 345 1 1
    IL24 SAMD4A 0 0 91 187 1 1
    IL24 IL33 0 0 335 335 1 1
    IL24 UTP11L 0 0 100 238 1 1
    IL24 HMOX1 0 0 126 165 1 2
    IL24 PEG3 0 0 186 186 1 1
    IL24 FOXP3 0 0 245 264 1 1
    IL24 IL6R 0 600 218 683 1 1
    IL24 IL32 0 0 467 487 1 1
    IL24 ING4 0 0 241 240 1 1
    IL24 HLA-DOB 0 0 47 163 1 1
    IL24 MDH2 0 0 139 295 1 1
    IL24 KLK3 0 0 193 193 1 1
    IL24 PNP 0 0 91 572 1 1
    IL24 CXCL8 0 0 451 483 1 1
    IL24 TCHP 0 0 180 179 1 1
    IL24 CD82 0 0 211 211 1 1
    IL24 IL1B 0 0 460 508 1 1
    IL24 IQCH 0 0 0 215 1 1
    IL24 HIF1A 0 0 180 179 1 2
    IL24 JAK1 0 600 325 718 1 1
    IL24 EIF2S1 0 0 245 244 1 2
    IL24 MMP12 0 0 142 160 1 1
    IL24 SCGB1A1 0 0 193 193 1 1
    IL24 SLC38A1 0 0 0 270 1 1
    IL24 TNFRSF1B 0 0 113 156 1 1
    IL24 TGFB1 0 0 134 176 1 1
    IL24 GADD45G 0 0 193 193 1 1
    IL24 STAT5B 0 0 253 252 1 1
    IL24 CXCR2 0 0 141 172 1 1
    IL24 RIPK3 270 0 53 321 1 1
    IL24 EGR1 0 0 135 289 1 1
    IL24 CD2 0 0 89 189 1 1
    IL24 CDKN1B 0 0 136 227 1 2
    IL24 CTNNB1 0 0 200 239 1 1
    IL24 TXLNA 0 0 177 201 1 1
    IL24 HRAS 65 0 254 272 1 1
    IL24 ACOT2 0 0 49 150 1 1
    IL24 IL25 0 0 213 222 1 1
    IL24 LIFR 0 600 0 600 1 1
    IL24 IL26 0 0 759 759 1 1
    IL24 RAD51 59 0 101 271 1 1
    IL24 IL36B 0 0 227 226 1 1
    IL24 IL11RA 0 600 141 641 1 1
    IL24 IRF8 0 0 113 176 1 1
    IL24 CD40LG 0 0 222 250 1 1
    IL24 SRC 0 0 166 165 1 1
    IL24 MMP1 0 0 243 261 1 1
    IL24 CDSN 0 0 125 179 1 1
    IL24 CXCR4 0 0 193 222 1 2
    IL24 CYR61 0 0 163 163 1 1
    IL24 IL17D 0 0 268 295 1 1
    IL24 CILP 0 0 90 164 1 1
    IL24 BNIP1 0 0 51 197 1 2
    IL24 TNFRSF1A 0 0 180 179 1 1
    IL24 GZMB 0 0 180 228 1 1
    IL24 TLR3 0 0 167 167 1 1
    IL24 IL19 0 800 857 856 1 1
    IL24 STAT1 0 600 380 741 1 1
    IL24 CADM1 0 0 504 579 1 1
    IL24 XPNPEP3 0 0 68 211 1 1
    IL24 CD52 0 0 0 154 1 1
    IL24 TREML1 0 0 0 439 1 1
    IL24 IL6 0 0 505 533 1 1
    IL24 EIF2AK3 0 0 217 217 1 2
    IL24 LPAR3 0 0 0 374 1 1
    IL24 IL3RA 0 600 122 640 1 1
    IL24 STAT6 0 0 241 268 1 1
    IL24 CLK3 0 0 66 210 1 1
    IL24 ZNF628 0 0 139 291 1 1
    IL24 IL11 0 0 451 451 1 1
    IL24 ZSCAN29 0 0 249 248 1 1
    IL24 GPT 0 0 54 216 1 1
    IL24 CCL5 0 0 213 278 1 1
    IL24 NXNL2 0 0 119 211 1 1
    IL24 IFNGR2 0 600 123 634 1 1
    IL24 IFNG 0 0 301 355 1 2
    IL24 SIRPB2 0 0 193 193 1 1
    IL24 IL2RB 0 600 211 694 1 1
    IL24 GPR18 0 0 54 199 1 1
    IL24 BCKDHA 0 0 0 231 1 1
    IL24 CXCL10 0 0 310 335 1 1
    IL24 RECK 0 0 184 183 1 1
    IL24 TNFSF9 0 0 180 179 1 1
    IL24 CXCL13 0 0 181 186 1 1
    IL24 IL6ST 0 600 96 631 1 1
    IL24 INSC 0 0 141 209 1 1
    IL24 TNFSF8 0 0 118 194 1 1
    IL24 CD1D 0 0 220 248 1 1
    IL24 IL4R 0 600 248 703 1 1
    IL24 CSDC2 0 0 282 282 1 1
    IL24 TLR9 0 0 127 158 1 1
    IL24 CR2 0 0 150 175 1 1
    IL24 MGMT 0 0 113 174 1 1
    IL24 KLK1 0 0 152 151 1 1
    IL24 VNN3 0 0 150 187 1 1
    IL24 PERP 0 0 156 219 1 1
    IL24 CD34 0 0 170 169 1 1
    IL24 ERBB2 0 0 241 240 1 2
    IL24 OSMR 0 600 54 605 1 1
    IL24 CRISP3 0 0 133 187 1 1
    IL24 ANXA5 0 0 325 325 1 1
    IL24 CCNB1 0 0 126 150 1 1
    IL24 CLCF1 0 0 127 177 1 1
    IL24 C19orf10 0 0 0 213 1 1
    IL24 KLK4 0 0 125 179 1 1
    IL24 AKT1 59 0 325 337 1 2
    IL24 TGFB2 0 0 155 154 1 1
    IL24 BCL2L1 0 0 400 400 1 2
    IL24 IL17C 0 0 380 403 1 1
    IL24 SP140 0 0 0 175 1 1
    IL24 ENSG00000255730 0 0 0 231 1 1
    IL24 CD48 0 0 42 155 1 1
    IL24 KLF6 0 0 134 229 1 1
    IL24 CSF2 0 0 390 405 1 1
    IL24 IL12RB1 0 600 171 654 1 1
    IL24 STAT4 0 0 255 275 1 1
    IL24 FAS 0 0 261 277 1 2
    IL24 EPHA8 0 0 48 194 1 1
    IL24 PI15 0 0 0 248 1 1
    IL24 CD4 0 0 390 407 1 1
    IL24 KLHL36 0 0 171 171 1 1
    IL24 TNFAIP8L1 0 0 157 156 1 1
    IL24 RD3 0 0 0 256 1 1
    IL24 CD83 0 0 113 189 1 1
    IL24 GAPDH 0 0 263 263 1 2
    IL24 IFNLR1 0 600 336 723 1 1
    IL24 RADIL 0 0 172 299 1 1
    IL24 IL9R 0 600 173 663 1 1
    IL24 SLC22A13 0 0 128 189 1 1
    IL24 TLR4 0 0 212 230 1 1
    IL24 XIAP 0 0 197 202 1 1
    IL24 EIF2B2 0 0 57 202 1 1
    IL24 POLL 0 0 403 403 1 1
    IL24 TNF 0 0 465 496 1 1
    IL24 TREM1 0 0 157 230 1 1
    IL24 ADNP 0 0 46 193 1 1
    IL24 IL36G 0 0 254 254 1 1
    IL24 PMP22 0 0 130 190 1 1
    IL24 IFNA1 0 0 358 358 1 1
    IL24 CD44 0 0 180 220 1 1
    IL24 UBAC1 0 0 391 390 1 1
    IL24 PURA 0 0 113 435 1 1
    IL24 IL18 0 0 325 325 1 1
    IL24 IL7 0 0 325 342 1 1
    IL24 IL1RN 0 0 207 267 1 1
    IL24 MYC 0 0 216 247 1 2
    IL24 MMP3 0 0 154 175 1 1
    IL24 S100A7 0 0 340 340 1 1
    IL24 IL15 0 0 338 338 1 1
    IL24 IL1R1 0 0 217 217 1 1
    IL24 SLC35F5 0 0 123 215 1 1
    IL24 SNAPC1 0 0 96 171 1 1
    IL24 FAIM3 0 0 337 418 1 1
    IL24 ITM2C 0 0 75 484 1 1
    IL24 IL2RA 0 600 188 671 1 1
    IL24 IL27RA 0 600 150 657 1 1
    IL24 OR6B3 0 0 156 174 1 1
    IL24 IL23R 0 600 218 673 1 1
    IL24 GPT2 0 0 0 260 1 1
    IL24 PPP1R15A 0 0 295 311 1 2
    IL24 ENSG00000272980 0 0 163 186 1 1
    IL24 IFNAR1 0 600 150 645 1 1
    IL24 TNFAIP6 0 0 292 317 1 1
    IL24 IL5 0 0 382 382 1 1
    IL24 IL1R2 0 0 294 328 1 1
    IL24 CD70 0 0 150 168 1 1
    IL24 STC1 0 0 224 224 1 1
    IL24 TNFAIP3 0 0 183 262 1 1
    IL24 IL34 0 0 218 240 1 1
    IL24 INHBA 0 0 166 188 1 1
    IL24 ST20 0 0 653 653 1 1
    IL24 FGF2 0 0 160 159 1 1
    IL24 OXA1L 0 0 47 175 1 1
    IL24 IL31RA 0 0 150 187 1 1
    IL24 CXCL3 0 0 324 339 1 1
    IL24 IFNL2 0 0 560 560 1 1
    IL24 TNFSF14 0 0 146 185 1 1
    IL24 PRLR 0 600 0 600 1 1
    IL24 BCL2A1 0 0 120 252 1 1
    IL24 MAP2K1 0 0 155 154 1 1
    IL24 IFNL1 0 0 631 631 1 1
    IL24 GADD45A 0 0 230 265 1 1
    IL24 DNAH14 0 0 181 181 1 1
    IL24 OSM 0 0 181 269 1 1
    IL24 C5 0 0 0 238 1 1
    IL24 ST13 0 0 218 397 1 2
    IL24 ATF3 0 0 180 179 1 1
    IL24 USP38 0 0 64 546 1 1
    IL24 OASL 0 0 117 150 1 1
    IL24 CD80 0 0 218 256 1 1
    IL24 DEFB4A 0 0 220 220 1 1
    IL24 DDX53 0 0 101 165 1 1
    IL24 IRF7 0 0 134 165 1 1
    IL24 SOCS1 0 0 204 231 1 1
    IL24 TLR1 0 0 81 161 1 1
    IL24 DEFB103A 0 0 193 193 1 1
    IL24 TNFAIP8 0 0 181 228 1 1
    IL24 EGFR 0 600 427 761 1 1
    IL24 CFLAR 0 0 205 224 1 1
    IL24 TSLP 0 0 261 261 1 1
    IL24 MUC1 0 0 123 183 1 1
    IL24 FADD 0 0 161 161 1 2
    IL24 P2RY10 0 0 0 175 1 1
    IL24 EPOR 0 600 0 600 1 1
    IL24 IL20RA 213 800 985 997 1 1
    IL24 PTPRCAP 0 0 74 156 1 1
    IL24 EGR2 0 0 66 159 1 1
    IL24 TP53 0 0 391 390 1 2
    IL24 ZSCAN2 0 0 138 271 1 1
    IL24 FAM3B 0 0 202 216 1 1
    IL24 CNTN6 0 0 122 176 1 1
    IL24 CD19 0 0 219 266 1 1
    IL24 DDIT3 0 0 302 302 1 2
    IL24 SELPLG 0 0 70 157 1 1
    IL24 BCL2L2 0 0 138 170 1 1
    IL24 STX2 0 0 131 197 1 1
    IL24 CCND1 0 0 181 181 1 1
    IL24 TRAF1 0 0 81 172 1 1
    IL24 APEH 0 0 241 240 1 1
    IL24 CD274 0 0 184 243 1 1
    IL24 CAMP 0 0 170 194 1 1
    IL24 CSF2RB 0 600 66 637 1 1
    IL24 RBL1 0 0 0 209 1 1
    IL24 FGF7 0 0 134 209 1 1
    IL24 ARPC2 0 0 0 209 1 1
    IL24 CSF3 0 0 212 235 1 1
    IL24 CIZ1 0 0 70 213 1 1
    IL24 IL20RB 800 800 928 996 1 1
    IL24 SNRPF 0 0 66 164 1 1
    IL24 VIT 0 0 107 162 1 1
    IL24 S100A7A 0 0 262 262 1 1
    IL24 ACTL7B 0 0 94 200 1 1
    IL24 CLU 270 0 97 317 1 2
    IL24 CTLA4 0 0 241 278 1 1
    IL24 CHGB 0 0 0 189 1 1
    IL24 FCER2 0 0 46 158 1 1
    IL24 CD46 0 0 183 183 1 1
    IL24 AFF1 0 0 0 173 1 1
    IL24 IFI44 0 0 109 158 1 1
    IL24 JAK2 0 0 181 181 1 1
    IL24 TMEM169 0 0 119 254 1 1
    IL24 RAX2 0 0 94 169 1 1
    IL24 LST1 0 0 81 219 1 1
    IL24 STAT3 0 600 501 791 1 2
    IL24 SRSF6 0 0 125 179 1 1
    IL24 NDUFA13 0 0 454 454 1 1
    IL24 CSRNP3 0 0 92 186 1 1
    IL24 ENSG00000264813 0 0 61 155 1 1
    IL24 PTOV1 0 0 95 151 1 1
    IL24 MSRB3 0 0 0 186 1 1
    IL24 PECAM1 0 0 182 181 1 1
    IL24 GATA3 0 0 214 214 1 1
    IL24 CCL1 0 0 167 167 1 1
    IL24 ZNF605 0 0 254 254 1 1
    IL24 AVIL 0 0 153 152 1 1
    IL24 TMEM80 0 0 124 271 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005125 Molecular Function cytokine activity enables IBA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0006915 Biological Process apoptotic process involved_in IEA
    GO:0071353 Biological Process cellular response to interleukin-4 involved_in IEA
    GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IEA
    GO:0006955 Biological Process immune response involved_in IBA
    GO:0030336 Biological Process negative regulation of cell migration involved_in IEA
    GO:0008285 Biological Process negative regulation of cell population proliferation involved_in IEA
    GO:0008284 Biological Process positive regulation of cell population proliferation involved_in IEA
    GO:2000273 Biological Process positive regulation of signaling receptor activity involved_in IBA
    GO:0007165 Biological Process signal transduction involved_in IEA
    GO:0005576 Cellular Component extracellular region located_in TAS
    GO:0005615 Cellular Component extracellular space is_active_in IBA
    Pathways
    Name DB ID
    Cytokine Signaling in Immune system Reactome R-HSA-1280215
    Immune System Reactome R-HSA-168256
    Signaling by Interleukins Reactome R-HSA-449147
    Interleukin-20 family signaling Reactome R-HSA-8854691
    Overview of proinflammatory and profibrotic mediators (WP5095) WikiPathways WP5095_r120801
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_047441763 1 mRNA transcript variant X1 NC_000001 Reference
    XM_047441774 1 mRNA transcript variant X2 NC_000001 Reference
    NM_001185156 1 mRNA transcript variant 3 NC_000001 Reference
    NM_001185157 1 mRNA transcript variant 4 NC_000001 Reference
    NM_006850 3 mRNA transcript variant 1 NC_000001 Reference
    NM_001185158 1 mRNA transcript variant 5 NC_000001 Reference
    XM_011509101 3 mRNA transcript variant X3 NC_000001 Reference