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CHM

CHM Rab escort protein
General Information
Name CHM Rab escort protein
Alias
  • rab proteins geranylgeranyltransferase component A 1
  • CHM, Rab escort protein 1
  • choroideremia (Rab escort protein 1)
Gene_family MicroRNA protein coding host genes
organism Homo sapiens
entrez_id 1121
location Xq21.2
transcript_count 9
exon_count 19
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
    Stringdb Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...]
    nextProt Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
CHM BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
CHM BioGRID CCAR2 GeneID BioGRID Co-fractionation
CHM BioGRID ADRM1 GeneID BioGRID Co-fractionation
CHM BioGRID HSPH1 GeneID BioGRID Co-fractionation
CHM BioGRID TAF6 GeneID BioGRID Co-fractionation
CHM BioGRID PSAP GeneID BioGRID Co-fractionation
CHM BioGRID HDAC2 GeneID BioGRID Co-fractionation
CHM BioGRID CHML GeneID BioGRID Negative Genetic
CHM BioGRID RAB12 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB14 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB35 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB10 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB7A GeneID BioGRID Affinity Capture-MS; Co-crystal Structure; Proximity Label-MS; Reconstituted Complex
CHM BioGRID VDAC3 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB5C GeneID BioGRID Affinity Capture-MS
CHM BioGRID RABGGTA GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB5B GeneID BioGRID Affinity Capture-MS
CHM BioGRID DYNC1H1 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB5A GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Reconstituted Complex
CHM BioGRID RAB4A GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB3A GeneID BioGRID Affinity Capture-MS; Reconstituted Complex; Two-hybrid
CHM BioGRID RAB1A GeneID BioGRID Affinity Capture-MS; Biochemical Activity; Reconstituted Complex
CHM BioGRID CNTF GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB43 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB7B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RASEF GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB2B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB33B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB1B GeneID BioGRID Affinity Capture-MS; Co-fractionation
CHM BioGRID RAB17 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB20 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB24 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB8B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB6B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB9B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB30 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB26 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB21 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB31 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB32 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB9A GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
CHM BioGRID RAB33A GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB11B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB29 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB11A GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB27B GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB27A GeneID BioGRID Affinity Capture-MS
CHM BioGRID TP53 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RAB2A GeneID BioGRID Proximity Label-MS
CHM BioGRID ZFP36L2 GeneID BioGRID Affinity Capture-MS
CHM BioGRID RBM3 GeneID BioGRID Affinity Capture-MS
CHM BioGRID Rab7 GeneID BioGRID Affinity Capture-MS
CHM BioGRID Rab5c GeneID BioGRID Affinity Capture-MS
CHM BioGRID VIL1 GeneID BioGRID Co-fractionation
CHM BioGRID KIF2A GeneID BioGRID Co-fractionation
CHM Protein RAB1B GeneID HPRD
CHM Protein RAB32 GeneID HPRD
CHM Protein RAB14 GeneID HPRD
CHM Protein RAB3D GeneID HPRD
CHM Protein RAB7A GeneID HPRD
CHM Protein RAB18 GeneID HPRD
CHM Protein RAB5B GeneID HPRD
CHM Protein RAB6A GeneID HPRD
CHM Protein RAB4A GeneID HPRD
CHM Protein RAB3B GeneID HPRD
CHM Protein RAB3A GeneID HPRD
CHM BioGRID RAB6A GeneID BioGRID Reconstituted Complex
StringDB
A B experiments database textmining combined score hadb nhadb
CHM AHCY 0 0 0 156 1 1
CHM RHEB 0 0 0 198 1 2
CHM AGBL2 0 0 252 268 1 1
CHM SLC6A16 0 0 0 158 1 1
CHM HPCA 0 0 0 202 1 1
CHM ADH6 0 0 415 414 1 1
CHM RAB14 213 600 181 771 1 1
CHM CYP4F22 0 0 96 152 1 1
CHM RRAS2 0 0 81 249 1 1
CHM TRIM61 0 0 81 159 1 1
CHM GBA 0 0 358 358 1 1
CHM RAB34 0 0 113 392 1 1
CHM DNAJC27 0 0 0 235 1 1
CHM TRAPPC13 0 900 0 902 1 1
CHM RAB3IP 0 900 134 919 1 1
CHM GUCY2F 0 0 0 165 1 1
CHM SASH1 0 0 0 151 1 1
CHM MAGI2 0 0 0 166 1 1
CHM VPS41 0 0 0 193 1 1
CHM GCH1 0 0 148 180 1 1
CHM SCAI 0 0 119 158 1 1
CHM HMGCR 0 0 0 162 1 1
CHM RRAD 0 0 0 250 1 1
CHM ENPP5 0 0 46 408 1 1
CHM RERGL 0 0 0 198 1 1
CHM EFS 0 0 73 442 1 1
CHM MCMBP 0 0 0 158 1 1
CHM RAB33A 0 0 0 331 1 1
CHM ARHGAP22 0 0 0 362 1 1
CHM STX8 0 0 108 153 1 2
CHM REM1 0 0 0 198 1 1
CHM CNGB3 0 0 402 415 1 1
CHM DENND4A 0 900 0 902 1 1
CHM ARIH2OS 0 0 271 271 1 1
CHM FAM122C 0 0 0 155 1 1
CHM APEH 0 0 260 292 1 1
CHM HERC3 0 0 0 625 1 1
CHM DCUN1D4 0 0 156 176 1 1
CHM RAB44 0 0 0 295 1 1
CHM TBC1D20 0 0 75 210 1 1
CHM ALDH2 0 0 325 329 1 2
CHM GPR143 0 0 92 187 1 1
CHM ARL16 0 0 0 198 1 1
CHM CLIC3 0 0 0 414 1 1
CHM MICAL3 0 0 142 160 1 1
CHM DENND1B 0 900 0 904 1 1
CHM EPG5 0 0 0 732 1 2
CHM ADH5 0 0 358 358 1 1
CHM ICMT 0 0 74 175 1 1
CHM ZMPSTE24 0 0 0 226 1 1
CHM RAB7A 696 600 946 998 1 2
CHM RAB40A 0 0 0 295 1 1
CHM USPL1 0 0 0 201 1 1
CHM HECW1 0 0 0 166 1 1
CHM GMFB 0 0 139 192 1 1
CHM ACMSD 0 0 218 218 1 1
CHM RHOF 0 0 0 198 1 1
CHM ASB11 0 0 0 166 1 1
CHM GNG13 0 0 397 396 1 1
CHM RPH3A 0 0 141 227 1 1
CHM STH 0 0 482 482 1 1
CHM ARHGAP24 0 0 0 175 1 1
CHM TCP1 0 0 308 323 1 1
CHM RND3 0 0 0 198 1 1
CHM TRAPPC2L 0 900 0 900 1 1
CHM SPESP1 0 0 156 155 1 1
CHM SLC6A13 0 0 0 158 1 1
CHM RAB23 0 0 105 269 1 2
CHM RAB39A 0 600 0 705 1 1
CHM NEDD4L 0 0 0 166 1 1
CHM RHEBL1 0 0 0 198 1 1
CHM MERTK 0 0 319 389 1 1
CHM RAB3GAP1 0 900 244 943 1 1
CHM CYLC1 0 0 66 162 1 1
CHM PKM 0 0 138 253 1 1
CHM ANKRD27 0 900 0 905 1 1
CHM RAB3C 0 0 0 215 1 1
CHM BEST1 0 0 320 324 1 1
CHM CEP290 0 0 487 498 1 1
CHM CASK 0 0 0 173 1 1
CHM RAB1B 735 600 142 931 1 2
CHM SLC6A9 0 0 0 158 1 1
CHM ZFP36L2 270 0 45 273 1 1
CHM ATP11C 0 0 0 168 1 1
CHM ASCC1 0 0 0 216 1 1
CHM CHIA 0 0 216 275 1 1
CHM NBR1 0 0 0 169 1 2
CHM SNAP25 0 0 103 164 1 1
CHM NUCKS1 0 0 126 160 1 1
CHM ALS2CL 0 900 0 900 1 1
CHM NXNL1 0 0 194 226 1 1
CHM ITCH 0 0 0 166 1 1
CHM RABL2B 0 0 0 263 1 1
CHM RBM8A 131 0 0 151 1 1
CHM ATP13A2 0 0 495 503 1 1
CHM REPS2 0 0 119 163 1 1
CHM HERC6 0 0 0 394 1 1
CHM CLEC10A 0 0 72 232 1 1
CHM ANKK1 0 0 434 434 1 1
CHM SUMO1 0 0 45 193 1 1
CHM ALS2 0 900 96 909 1 1
CHM SNRPB2 0 0 0 300 1 1
CHM GNAL 0 0 357 378 1 1
CHM USO1 0 0 0 191 1 1
CHM RBM15B 0 0 108 244 1 1
CHM UCKL1 0 0 47 169 1 1
CHM RAB40C 0 0 0 295 1 1
CHM ARL15 0 0 0 198 1 1
CHM SF3A3 131 0 0 152 1 1
CHM SETX 0 0 72 249 1 1
CHM UBE3A 0 0 0 470 1 1
CHM RASD2 0 0 0 198 1 1
CHM TRAPPC12 0 900 0 901 1 1
CHM ARL5A 0 0 0 217 1 1
CHM ERP29 0 0 0 161 1 1
CHM GGT1 0 0 167 176 1 1
CHM ARF4 0 0 0 198 1 1
CHM XIAP 0 0 67 163 1 2
CHM PDK3 0 0 0 519 1 1
CHM ATP7A 0 0 0 152 1 1
CHM GDI2 0 900 170 915 1 1
CHM EIF3L 0 0 0 150 1 1
CHM UBTD1 0 0 66 276 1 1
CHM SLFNL1 0 0 261 388 1 1
CHM TNKS2 0 0 85 159 1 1
CHM POLA1 131 0 66 195 1 1
CHM USH2A 0 0 203 240 1 1
CHM PMS2 0 0 0 152 1 1
CHM RHOC 0 0 45 206 1 1
CHM PHGDH 0 0 172 171 1 1
CHM CDC16 0 0 93 168 1 1
CHM RAB21 0 600 213 689 1 1
CHM OPN3 0 0 309 309 1 1
CHM PINK1 0 0 259 258 1 2
CHM THOC2 0 0 0 160 1 1
CHM OTUD7A 0 0 123 187 1 1
CHM YIPF5 0 0 0 179 1 1
CHM OPRK1 0 0 357 357 1 1
CHM CHRM2 0 0 390 390 1 1
CHM ELAC1 0 0 141 159 1 1
CHM GOSR1 0 0 0 164 1 1
CHM NMT2 0 0 113 186 1 1
CHM RAB25 0 0 122 325 1 2
CHM ADA 0 0 57 219 1 1
CHM SMURF2 0 0 0 166 1 1
CHM CDC42 0 0 120 303 1 2
CHM GPN2 0 0 0 198 1 1
CHM EEA1 0 0 107 165 1 2
CHM DENND5A 0 900 95 909 1 1
CHM KDM6A 0 0 0 159 1 1
CHM APOE 0 0 242 241 1 2
CHM TCTE3 0 0 578 587 1 1
CHM WWP2 0 0 0 166 1 1
CHM YIPF4 0 0 0 183 1 1
CHM KLHL7 0 0 0 151 1 1
CHM SLC6A20 0 0 0 158 1 1
CHM DENND2C 0 900 0 909 1 1
CHM RABGEF1 0 900 422 948 1 1
CHM ROBO2 0 0 0 543 1 1
CHM RPE65 0 0 557 570 1 1
CHM UTP14A 0 0 0 168 1 1
CHM RAC2 0 0 60 214 1 1
CHM RAB11A 145 0 441 622 1 2
CHM CHML 0 900 947 902 1 1
CHM CCZ1 0 900 0 907 1 1
CHM SKP1 0 0 0 369 1 2
CHM PRIM2 131 0 0 152 1 1
CHM SLC6A2 0 0 64 179 1 1
CHM RHOH 0 0 0 198 1 1
CHM TRAPPC6B 0 900 0 909 1 1
CHM RB1 0 0 0 226 1 2
CHM NIPAL3 0 0 66 376 1 1
CHM CTCF 0 0 260 260 1 1
CHM SBF2 0 900 0 905 1 1
CHM GATB 0 0 55 239 1 1
CHM RABIF 0 0 161 260 1 1
CHM OXSM 0 0 0 177 1 1
CHM RAB7B 478 600 987 998 1 1
CHM HACE1 0 0 0 237 1 1
CHM TRAPPC1 0 900 81 913 1 1
CHM RAB28 0 0 180 404 1 1
CHM HECTD1 0 0 0 185 1 1
CHM USH1C 0 0 66 210 1 1
CHM VIL1 272 0 0 294 1 1
CHM POLR3A 131 0 0 155 1 1
CHM GDI1 0 900 325 918 1 1
CHM KIF2A 272 0 0 272 1 1
CHM DIRAS3 0 0 0 198 1 2
CHM ASZ1 0 0 106 163 1 1
CHM DLG3 0 0 0 179 1 1
CHM RAD21 0 0 210 210 1 1
CHM RAB20 0 0 0 313 1 1
CHM PLA2G6 0 0 203 203 1 1
CHM TULP1 0 0 95 176 1 1
CHM GAPVD1 0 900 108 912 1 1
CHM KANSL1 0 0 499 499 1 1
CHM SMURF1 0 0 0 166 1 1
CHM SLC6A14 0 0 0 190 1 1
CHM RAB4B 0 0 0 216 1 1
CHM MASP2 0 0 0 175 1 1
CHM RAB2B 0 0 0 258 1 1
CHM WWC3 0 0 0 198 1 1
CHM RAB42 0 0 395 562 1 1
CHM RIN2 0 900 0 911 1 1
CHM WNT3 0 0 322 321 1 1
CHM TMEM115 0 0 134 152 1 1
CHM POC1A 0 0 48 308 1 1
CHM TUBG1 0 0 296 311 1 1
CHM NMUR2 0 0 0 303 1 1
CHM CA11 0 0 202 251 1 1
CHM JAZF1 0 0 0 343 1 1
CHM RIN1 0 900 172 918 1 1
CHM RAB19 0 0 0 331 1 1
CHM RABAC1 0 0 286 338 1 1
CHM NRAS 0 0 0 217 1 1
CHM RND2 0 0 0 198 1 1
CHM CNGA3 0 0 324 323 1 1
CHM RAB39B 0 600 57 705 1 1
CHM KRAS 0 0 58 249 1 2
CHM RP2 0 0 61 157 1 1
CHM MON1A 0 900 0 912 1 1
CHM WDR59 131 0 0 192 1 1
CHM RHOD 0 0 0 198 1 1
CHM MOBP 0 0 243 261 1 1
CHM ALG10 0 0 124 187 1 1
CHM GAS7 0 0 0 184 1 1
CHM RAB30 184 0 0 472 1 1
CHM EXPH5 0 0 435 435 1 1
CHM FAF1 131 0 0 165 1 1
CHM RAB11B 220 0 47 404 1 1
CHM COPS6 131 0 0 182 1 1
CHM TRAPPC2 0 900 0 911 1 1
CHM SRP14 0 0 0 256 1 1
CHM EIF1AX 0 0 0 177 1 1
CHM REM2 0 0 0 198 1 1
CHM RAB3D 213 0 287 527 1 1
CHM MASP1 0 0 120 472 1 1
CHM RASL10B 0 0 0 198 1 1
CHM TMF1 0 0 0 303 1 1
CHM CLIC1 0 0 43 419 1 1
CHM OTC 0 0 47 285 1 1
CHM RHOBTB3 0 0 0 198 1 1
CHM ARF6 0 0 66 219 1 1
CHM ARL4C 0 0 0 198 1 1
CHM RASL11A 0 0 0 198 1 1
CHM NAPA 0 0 48 164 1 1
CHM MAPT 0 0 415 454 1 2
CHM STK38L 0 0 150 220 1 1
CHM MET 0 0 46 217 1 2
CHM NCALD 0 0 0 155 1 1
CHM LRRK2 0 0 459 468 1 2
CHM CPSF3 0 0 0 317 1 1
CHM MLH1 0 0 0 150 1 1
CHM PTGER3 0 0 0 365 1 1
CHM HPS4 0 900 0 901 1 1
CHM RAB13 0 600 120 733 1 2
CHM ATAD1 0 0 0 161 1 1
CHM RAC1 0 0 45 202 1 2
CHM PDK4 0 0 0 499 1 1
CHM TRAPPC5 0 900 122 911 1 1
CHM HECTD3 0 0 0 169 1 1
CHM RAB22A 0 0 82 343 1 1
CHM FKTN 0 0 0 188 1 1
CHM FAM122B 131 0 0 203 1 1
CHM SRRM1 0 0 0 321 1 1
CHM SLC6A3 0 0 262 352 1 1
CHM MIB1 0 0 0 214 1 1
CHM TRAPPC6A 0 900 0 905 1 1
CHM YAP1 0 0 0 166 1 2
CHM ITGB3 0 0 0 225 1 1
CHM MYO7A 0 0 261 281 1 1
CHM RAB15 0 0 0 295 1 1
CHM MTMR8 0 0 0 180 1 1
CHM AGFG1 0 0 845 851 1 1
CHM SASS6 0 0 411 410 1 1
CHM RIN3 0 900 0 905 1 1
CHM PIGY 0 0 57 154 1 1
CHM ARL13B 0 0 0 220 1 1
CHM TBC1D8B 0 0 0 156 1 1
CHM RAB3A 680 600 511 944 1 1
CHM HS1BP3 0 0 167 177 1 2
CHM RLBP1 0 0 155 204 1 1
CHM CDC45 0 0 0 562 1 1
CHM UBTD2 0 0 0 256 1 1
CHM SCRN3 0 0 0 169 1 1
CHM GEM 0 0 0 198 1 1
CHM MPST 131 0 0 169 1 1
CHM RASL11B 0 0 0 198 1 1
CHM BEST2 0 0 0 206 1 1
CHM RALA 0 0 54 209 1 1
CHM IFT27 0 0 0 270 1 1
CHM RASL10A 0 0 0 198 1 1
CHM STX7 0 0 93 153 1 2
CHM DENND2A 0 900 0 910 1 1
CHM UBE3B 0 0 0 166 1 1
CHM ISM2 0 0 182 181 1 1
CHM NMUR1 0 0 0 543 1 1
CHM GABRA6 0 0 397 396 1 1
CHM HPS1 0 900 0 900 1 1
CHM ENSG00000267261 0 0 0 325 1 1
CHM DIRAS2 0 0 0 198 1 1
CHM POLR3H 131 0 0 150 1 1
CHM DENND5B 0 900 0 905 1 1
CHM PLEKHA7 0 0 0 166 1 1
CHM HIST1H1C 0 0 398 398 1 1
CHM SUGCT 0 0 181 181 1 1
CHM GNPDA2 0 0 0 154 1 1
CHM RAB41 0 0 0 343 1 1
CHM GUCY2D 0 0 113 168 1 1
CHM ST5 0 900 0 920 1 1
CHM NPM1 0 0 0 212 1 1
CHM CDR2 0 0 150 169 1 1
CHM CNTLN 0 0 293 293 1 1
CHM MRAS 0 0 0 198 1 1
CHM MT-ND4 0 0 244 271 1 1
CHM SYTL2 0 0 433 433 1 1
CHM OPHN1 0 0 0 157 1 1
CHM PPP3R1 0 0 107 177 1 1
CHM AREL1 0 0 49 176 1 1
CHM RPL38 0 0 0 169 1 1
CHM OPRD1 0 0 306 306 1 1
CHM WDR7 0 0 204 279 1 1
CHM DMD 0 0 143 278 1 2
CHM TAS2R16 0 0 458 457 1 1
CHM OR2C3 0 0 266 266 1 1
CHM PANK2 0 0 218 253 1 1
CHM NREP 0 0 0 354 1 1
CHM RAB5C 394 600 47 823 1 1
CHM HECW2 0 0 106 222 1 1
CHM SRP9 0 0 67 252 1 1
CHM RAB27B 145 600 294 760 1 1
CHM RABGGTA 741 720 93 969 1 1
CHM MSH3 0 0 42 300 1 1
CHM AIPL1 0 0 151 161 1 1
CHM NUP98 131 0 0 150 1 1
CHM RHOT2 0 0 0 198 1 1
CHM MYRIP 0 0 92 154 1 1
CHM CLIC4 0 0 0 341 1 1
CHM ATAD2B 0 0 0 182 1 1
CHM CHURC1-FNTB 0 0 0 363 1 1
CHM CACNA1D 0 0 0 188 1 1
CHM FNTA 0 0 73 470 1 1
CHM RBM3 270 0 0 270 1 1
CHM LTN1 0 0 0 738 1 1
CHM S100A5 0 0 113 176 1 1
CHM ADH1C 0 0 304 304 1 1
CHM EXOC2 0 0 0 163 1 1
CHM DIRAS1 0 0 0 198 1 1
CHM POLR3B 131 0 0 154 1 1
CHM FAM104B 0 0 0 181 1 1
CHM CACNA1F 0 0 82 222 1 1
CHM PSMD10 0 0 0 150 1 1
CHM RBFOX2 0 0 123 186 1 1
CHM RPGR 0 0 409 468 1 1
CHM HUWE1 0 0 0 251 1 1
CHM RAB8A 270 600 416 863 1 2
CHM UBR5 0 0 0 186 1 1
CHM OCRL 0 0 82 201 1 1
CHM SCRN1 0 0 0 169 1 1
CHM ZNF724P 0 0 293 308 1 1
CHM TRIM23 0 0 0 217 1 1
CHM PPP1R12C 0 0 181 245 1 1
CHM RLIM 0 0 0 225 1 1
CHM RAB9A 274 600 82 832 1 2
CHM TIMM23B 0 0 148 160 1 1
CHM MSL3 0 0 74 170 1 1
CHM RAB2A 0 0 95 299 1 1
CHM YIF1A 0 0 0 228 1 1
CHM SLC6A15 0 0 0 158 1 1
CHM HECTD2 0 0 0 433 1 1
CHM RASEF 0 0 0 295 1 1
CHM RAB4A 213 0 180 450 1 1
CHM ESX1 0 0 49 293 1 1
CHM BST1 0 0 164 163 1 1
CHM RNF115 0 0 133 151 1 1
CHM NRXN3 0 0 398 398 1 1
CHM ADH1A 0 0 387 386 1 1
CHM RAB3IL1 0 900 0 911 1 1
CHM DENND4C 0 900 53 901 1 1
CHM ARPC2 0 0 0 169 1 1
CHM RAF1 0 0 510 510 1 2
CHM C1orf52 0 0 144 337 1 1
CHM PEF1 0 0 218 386 1 1
CHM RAB10 270 600 211 824 1 1
CHM MCAT 0 0 122 402 1 1
CHM ARF5 0 0 0 198 1 1
CHM MOSPD2 0 0 0 176 1 1
CHM RINL 0 900 0 905 1 1
CHM ADAMDEC1 0 0 91 186 1 1
CHM SLC6A1 0 0 0 158 1 1
CHM MLPH 0 0 413 412 1 1
CHM PARK7 0 0 295 303 1 2
CHM GRK1 0 0 218 219 1 1
CHM SLC6A7 0 0 0 158 1 1
CHM YIPF7 0 0 0 179 1 1
CHM TCP10 0 0 415 414 1 1
CHM ENSG00000272772 0 0 0 471 1 1
CHM PLEKHA5 0 0 0 166 1 1
CHM MAGI1 0 0 0 166 1 1
CHM SCML2 0 0 112 166 1 1
CHM RSG1 0 0 0 198 1 1
CHM PARK2 0 0 304 304 1 1
CHM TRAPPC9 0 900 116 915 1 1
CHM SLC6A4 0 0 0 158 1 1
CHM WDR44 0 0 61 163 1 1
CHM ARL8B 0 0 0 198 1 1
CHM MYC 0 0 180 179 1 2
CHM PDK1 0 0 0 499 1 2
CHM BTBD9 0 0 268 274 1 1
CHM EDDM3A 0 0 338 338 1 1
CHM RAB3B 213 0 67 373 1 1
CHM RIT1 0 0 0 198 1 1
CHM GNPDA1 0 0 0 153 1 1
CHM TMEM52B 0 0 0 225 1 1
CHM ROBO4 0 0 0 383 1 1
CHM PHYHIP 0 0 156 161 1 1
CHM GLS 0 0 517 517 1 2
CHM TMBIM6 0 0 66 173 1 1
CHM DENND1C 0 900 0 904 1 1
CHM ENSG00000261832 0 0 124 164 1 1
CHM THAP9 0 0 67 268 1 1
CHM GNAT2 0 0 156 184 1 1
CHM CETN3 0 0 213 231 1 1
CHM WWTR1 0 0 0 166 1 1
CHM SYT11 0 0 181 181 1 1
CHM YY1AP1 0 0 160 159 1 1
CHM TAB3 0 0 0 175 1 1
CHM LONRF2 0 0 0 176 1 1
CHM LECT1 0 0 150 243 1 1
CHM RAN 0 0 0 162 1 2
CHM TUBB4A 0 0 135 176 1 1
CHM RAB33B 0 0 0 356 1 2
CHM RAB40AL 0 0 0 295 1 1
CHM PLK4 0 0 398 398 1 1
CHM COPG1 0 0 252 349 1 1
CHM RAB18 213 600 0 718 1 1
CHM GAPDH 0 0 155 174 1 2
CHM CHD7 0 0 264 292 1 1
CHM RIT2 0 0 72 224 1 1
CHM ENO1 0 0 193 230 1 1
CHM WWC1 0 0 0 166 1 1
CHM SLC6A5 0 0 0 158 1 1
CHM ARL5B 0 0 0 217 1 1
CHM RAP1A 0 0 159 297 1 1
CHM RCE1 0 0 140 320 1 1
CHM ARL3 0 0 0 198 1 1
CHM ARF1 0 0 74 226 1 1
CHM RHOBTB2 0 0 0 198 1 1
CHM NFATC2IP 0 0 0 190 1 1
CHM CIDEC 0 0 0 150 1 1
CHM STAG2 0 0 0 155 1 1
CHM CRACR2A 0 0 0 295 1 1
CHM ARL14 0 0 0 198 1 1
CHM BCKDHB 0 0 0 169 1 1
CHM WWP1 0 0 0 166 1 1
CHM HSPD1 0 0 126 282 1 1
CHM RHOJ 0 0 0 198 1 1
CHM RAB40B 0 0 0 295 1 1
CHM RS1 0 0 391 508 1 1
CHM AGGF1 131 0 0 298 1 1
CHM CS 131 0 0 150 1 1
CHM REP15 0 0 460 459 1 1
CHM UGDH 0 0 129 158 1 1
CHM ZFX 0 0 97 169 1 1
CHM HDX 0 0 0 156 1 1
CHM TRIP12 0 0 0 166 1 1
CHM FNTB 0 0 0 373 1 1
CHM NCS1 0 0 0 150 1 1
CHM DENND2D 0 900 0 904 1 1
CHM TRAPPC8 0 900 0 906 1 1
CHM MAST1 0 0 0 160 1 1
CHM RRAS 0 0 74 226 1 1
CHM TCTE1 0 0 436 444 1 1
CHM RAD51 0 0 155 154 1 2
CHM MYO5A 0 0 113 153 1 1
CHM RHOU 0 0 0 198 1 1
CHM SNRPA 0 0 0 190 1 1
CHM CLC 0 0 255 254 1 1
CHM SUMO4 0 0 0 190 1 1
CHM BRWD3 0 0 0 192 1 1
CHM RAB12 270 600 92 874 1 2
CHM SHE 0 0 164 163 1 1
CHM CCNF 0 0 328 328 1 1
CHM LMLN 0 0 95 459 1 1
CHM RAB5A 677 600 294 930 1 2
CHM RAB5B 213 600 125 789 1 1
CHM NEDD4 0 0 0 166 1 2
CHM BAG3 0 0 0 166 1 2
CHM ARF3 0 0 0 198 1 1
CHM RAB6B 130 600 0 751 1 1
CHM CLN3 0 0 122 162 1 2
CHM SUMO2 0 0 0 190 1 1
CHM RANBP17 0 0 0 196 1 1
CHM ARL8A 0 0 0 198 1 1
CHM WDR26 131 0 0 150 1 1
CHM HRAS 0 0 57 230 1 2
CHM INPP5B 0 0 0 159 1 1
CHM HERC5 0 0 0 394 1 1
CHM ATE1 131 0 74 188 1 1
CHM SLC38A1 0 0 0 203 1 1
CHM WWC2 0 0 0 166 1 1
CHM EFCAB3 0 0 0 438 1 1
CHM NMT1 0 0 74 155 1 1
CHM RAB17 278 0 0 483 1 1
CHM MCCC1 0 0 210 226 1 1
CHM RHO 0 0 314 332 1 2
CHM ARL1 0 0 0 198 1 1
CHM DCLK3 0 0 0 217 1 1
CHM RHOBTB1 0 0 48 204 1 1
CHM CLDN5 0 0 55 159 1 1
CHM ACTB 0 0 250 274 1 2
CHM ARHGDIA 0 0 0 152 1 1
CHM RPS6KA6 0 0 112 203 1 1
CHM EPRS 0 0 51 173 1 1
CHM ARL6 0 0 0 198 1 1
CHM STK38 0 0 0 153 1 1
CHM RND1 0 0 0 198 1 1
CHM SQSTM1 0 0 0 150 1 2
CHM SBF1 0 900 62 908 1 1
CHM TMTC1 0 0 398 424 1 1
CHM EXOC5 0 0 0 211 1 1
CHM RHOV 0 0 48 204 1 1
CHM SYT1 0 0 306 307 1 1
CHM PDE6G 0 0 90 230 1 1
CHM HTRA2 0 0 143 158 1 1
CHM SLC6A6 0 0 0 158 1 1
CHM ABCA4 0 0 451 487 1 1
CHM VPS13C 0 0 141 174 1 1
CHM CCP110 0 0 539 539 1 1
CHM RAB29 298 0 206 479 1 1
CHM ENSG00000271810 0 0 0 198 1 1
CHM COBLL1 0 0 95 226 1 1
CHM ADH1B 0 0 387 386 1 1
CHM RHOG 0 0 103 250 1 1
CHM RAB1A 681 600 520 953 1 1
CHM RAB35 0 600 66 696 1 1
CHM TMEM175 0 0 125 198 1 1
CHM RASL12 0 0 0 198 1 1
CHM R3HDM1 0 0 138 155 1 1
CHM ADH7 0 0 398 398 1 1
CHM TAS2R38 0 0 388 388 1 1
CHM HBS1L 0 0 123 164 1 1
CHM PDK2 0 0 0 499 1 1
CHM TRAPPC4 0 900 73 912 1 1
CHM ROBO1 0 0 0 543 1 1
CHM POU3F4 0 0 166 165 1 1
CHM IGDCC3 0 0 88 466 1 1
CHM RALB 0 0 0 198 1 2
CHM RAB24 0 0 81 346 1 2
CHM ERAS 0 0 0 198 1 1
CHM NKRF 0 0 0 179 1 1
CHM RHOA 0 0 93 272 1 2
CHM DENND4B 0 900 0 900 1 1
CHM RHOQ 0 0 66 219 1 1
CHM BEST4 0 0 0 245 1 1
CHM UCHL1 0 0 182 214 1 2
CHM RAB27A 0 600 689 881 1 1
CHM RAP2C 0 0 0 229 1 1
CHM PUM2 0 0 94 172 1 1
CHM MOB2 0 0 46 176 1 1
CHM MAST2 0 0 0 189 1 1
CHM RASD1 0 0 0 198 1 1
CHM PCSK4 0 0 0 188 1 1
CHM MON1B 0 900 0 912 1 1
CHM YWHAE 0 900 0 907 1 1
CHM VCP 0 0 66 164 1 2
CHM UBXN8 0 0 557 574 1 1
CHM ARL10 0 0 0 198 1 1
CHM MYRF 0 0 150 188 1 1
CHM USH1G 0 0 94 160 1 1
CHM RABL2A 0 0 53 272 1 1
CHM RILP 0 0 233 232 1 1
CHM CENPJ 0 0 397 396 1 1
CHM AKR1C2 0 0 368 378 1 1
CHM LAMB1 0 0 84 153 1 1
CHM MIB2 0 0 0 214 1 1
CHM PNRC1 0 0 184 229 1 1
CHM TBL1X 0 0 202 233 1 1
CHM SCRN2 0 0 0 185 1 1
CHM CEP135 0 0 410 410 1 1
CHM CCDC47 0 0 72 174 1 1
CHM FBL 0 0 234 234 1 2
CHM DENND3 0 900 0 900 1 2
CHM ARL4A 0 0 0 198 1 1
CHM UBE3C 0 0 0 166 1 1
CHM SLC6A17 0 0 0 158 1 1
CHM RHOT1 0 0 45 208 1 1
CHM DENND6A 0 900 0 902 1 1
CHM SCO1 0 0 0 160 1 1
CHM SLC6A12 0 0 0 158 1 1
CHM RASA4B 0 0 94 150 1 1
CHM ALG13 0 0 0 177 1 1
CHM CD74 0 0 0 227 1 1
CHM DENND1A 0 900 0 904 1 1
CHM SNCA 0 0 681 681 1 2
CHM ARL17B 0 0 48 204 1 1
CHM HPCAL1 0 0 0 270 1 1
CHM DGKQ 0 0 218 238 1 1
CHM ELOVL4 0 0 134 195 1 1
CHM ALG10B 0 0 123 187 1 1
CHM EXOC6 0 0 82 165 1 1
CHM YIPF6 0 0 0 264 1 1
CHM RAC3 0 0 0 198 1 2
CHM RUSC2 0 0 57 201 1 1
CHM ARL5C 0 0 0 198 1 1
CHM PAICS 0 0 165 183 1 1
CHM DDX19B 131 0 0 165 1 1
CHM RAB31 485 600 67 850 1 1
CHM GAK 0 0 310 370 1 1
CHM SLC6A11 0 0 48 165 1 1
CHM SLC6A8 0 0 0 158 1 1
CHM ARL11 0 0 0 198 1 1
CHM RAB8B 130 600 0 733 1 2
CHM ENSG00000273554 0 0 0 158 1 1
CHM CRHR1 0 0 305 305 1 1
CHM TYR 0 0 107 161 1 2
CHM ETV5 0 0 240 239 1 1
CHM PMEL 0 0 0 188 1 1
CHM FBXO7 0 0 223 223 1 1
CHM RDH5 0 0 162 161 1 1
CHM LPL 0 0 81 285 1 1
CHM RABGGTB 0 720 287 960 1 1
CHM HSP90B1 131 0 0 176 1 1
CHM RABL6 0 0 0 331 1 1
CHM PDE6B 0 0 270 285 1 1
CHM SMU1 131 0 0 196 1 1
CHM DENND6B 0 900 0 902 1 1
CHM KRIT1 0 0 123 198 1 1
CHM HIST2H3PS2 0 0 203 203 1 1
CHM RSPH3 0 0 0 188 1 1
CHM CXorf38 0 0 0 156 1 1
CHM GZF1 0 0 156 591 1 1
CHM SMARCB1 0 0 0 246 1 1
CHM CENPW 0 0 0 303 1 1
CHM NSRP1 0 0 0 343 1 1
CHM C15orf57 0 0 75 176 1 1
CHM TRAPPC11 0 900 0 902 1 1
CHM STX1B 0 0 150 165 1 1
CHM NEUROD6 0 0 271 271 1 1
CHM SUMO3 0 0 0 190 1 1
CHM RAB43 0 0 74 369 1 1
CHM ARL9 0 0 0 198 1 1
CHM VIM 0 0 181 181 1 2
CHM CMBL 0 0 0 155 1 2
CHM TRAPPC10 0 900 0 906 1 1
CHM RAB6A 270 600 393 868 1 1
CHM RAB38 0 600 321 780 1 1
CHM BEST3 0 0 0 197 1 1
CHM IPO11 0 0 150 239 1 1
CHM MAGIX 0 0 0 166 1 1
CHM ARL4D 0 0 0 198 1 1
CHM BCKDK 0 0 0 371 1 1
CHM RAB36 0 0 0 343 1 1
CHM RGP1 0 900 0 901 1 1
CHM SIRT6 0 0 0 224 1 2
CHM CAP2 0 0 0 153 1 1
CHM PRPH2 0 0 260 263 1 1
CHM RAB3GAP2 0 900 0 928 1 1
CHM RAB9B 470 600 85 881 1 1
CHM RAB32 650 600 143 890 1 2
CHM SPCS1 0 0 0 177 1 1
CHM RAP2B 0 0 0 198 1 1
CHM CABP4 0 0 99 175 1 1
CHM PGGT1B 0 0 0 507 1 1
CHM VPS35 0 0 202 274 1 2
CHM RAB6C 0 0 42 344 1 1
CHM RIC1 0 900 49 903 1 1
CHM RERG 0 0 0 198 1 1
CHM CUL5 0 0 0 153 1 1
CHM DCTN1 0 0 108 274 1 1
CHM SLC6A18 0 0 0 158 1 1
CHM MAGI3 0 0 0 211 1 1
CHM KLHL6 0 0 0 151 1 1
CHM TFPI 0 0 210 210 1 1
CHM AVP 0 0 295 307 1 1
CHM RHOB 0 0 53 248 1 1
CHM MAP7D3 0 0 0 183 1 1
CHM ALB 0 0 151 157 1 2
CHM XPO7 0 0 0 201 1 1
CHM SLC6A19 0 0 0 158 1 1
CHM NAPB 0 0 0 158 1 1
CHM HERC4 0 0 0 625 1 1
CHM EVPLL 0 0 149 167 1 1
CHM RABEP1 0 0 128 209 1 1
CHM PGK1 0 0 124 173 1 2
CHM ENSG00000255863 0 0 0 198 1 1
CHM RAP2A 0 0 0 198 1 1
CHM TRAPPC3 0 900 0 907 1 1
CHM ENSG00000272822 0 0 0 198 1 1
CHM PKLR 0 0 0 169 1 1
CHM RAP1B 0 0 0 198 1 1
CHM DBT 0 0 208 231 1 2
CHM TROVE2 0 0 0 279 1 1
CHM SLBP 0 0 103 232 1 1
CHM RNF123 0 0 0 246 1 1
CHM CNTF 145 0 119 220 1 1
CHM ARL17A 0 0 54 209 1 1
CHM MADD 0 900 95 909 1 1
CHM PPEF1 0 0 54 156 1 1
CHM ROBO3 0 0 0 543 1 1
CHM SLC2A13 0 0 150 523 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005092 Molecular Function GDP-dissociation inhibitor activity enables IEA
GO:0005096 Molecular Function GTPase activator activity enables IEA
GO:0004663 Molecular Function Rab geranylgeranyltransferase activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0031267 Molecular Function small GTPase binding enables IDA
GO:0031267 Molecular Function small GTPase binding enables IPI
GO:0018344 Biological Process protein geranylgeranylation involved_in IBA
GO:0018344 Biological Process protein geranylgeranylation involved_in IDA
GO:0006612 Biological Process protein targeting to membrane involved_in IMP
GO:0007264 Biological Process small GTPase mediated signal transduction involved_in IEA
GO:0016192 Biological Process vesicle-mediated transport involved_in IBA
GO:0007601 Biological Process visual perception involved_in IEA
GO:0005968 Cellular Component Rab-protein geranylgeranyltransferase complex part_of IBA
GO:0005968 Cellular Component Rab-protein geranylgeranyltransferase complex part_of IDA
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005829 Cellular Component cytosol is_active_in IBA
GO:0005829 Cellular Component cytosol located_in IMP
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005634 Cellular Component nucleus is_active_in IBA
Pathways
Name DB ID
Membrane Trafficking Reactome R-HSA-199991
Generic Transcription Pathway Reactome R-HSA-212436
Transcriptional Regulation by TP53 Reactome R-HSA-3700989
Metabolism of proteins Reactome R-HSA-392499
TP53 Regulates Transcription of Cell Death Genes Reactome R-HSA-5633008
Vesicle-mediated transport Reactome R-HSA-5653656
Post-translational protein modification Reactome R-HSA-597592
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Reactome R-HSA-6803205
RNA Polymerase II Transcription Reactome R-HSA-73857
Gene expression (Transcription) Reactome R-HSA-74160
RAB geranylgeranylation Reactome R-HSA-8873719
RAB GEFs exchange GTP for GDP on RABs Reactome R-HSA-8876198
Rab regulation of trafficking Reactome R-HSA-9007101
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_000390 4 mRNA transcript variant 1 NC_000023 Reference
XM_047441793 1 mRNA transcript variant X2 NC_000023 Reference
NM_001362519 1 mRNA transcript variant 6 NC_000023 Reference
NM_001362517 1 mRNA transcript variant 4 NC_000023 Reference
XM_047441794 1 mRNA transcript variant X3 NC_000023 Reference
NM_001320959 1 mRNA transcript variant 3 NC_000023 Reference
NM_001362518 2 mRNA transcript variant 5 NC_000023 Reference
XM_017029242 3 mRNA transcript variant X1 NC_000023 Reference
NM_001145414 4 mRNA transcript variant 2 NC_000023 Reference