HAdb 2.0 is available now!

ECD

ecdysoneless cell cycle regulator
General Information
Name ecdysoneless cell cycle regulator
Alias
  • protein ecdysoneless homolog
  • ecdysoneless homolog
  • human suppressor of GCR two
  • protein SGT1
  • suppressor of GCR2
  • suppressor of S. cerevisiae gcr2
Gene_family
organism Homo sapiens
entrez_id 11319
location 10q22.2
transcript_count 4
exon_count 15
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Enables histone acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Protein ecdysoneless homolog; Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the [...]
    nextProt Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
ECD BioGRID ATG16L1 GeneID BioGRID Proximity Label-MS
ECD BioGRID CTNNA1 GeneID BioGRID Proximity Label-MS
ECD BioGRID KBTBD4 GeneID BioGRID Proximity Label-MS
ECD BioGRID GSK3B GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
ECD BioGRID GSK3A GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
ECD BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
ECD BioGRID GABRA1 GeneID BioGRID Affinity Capture-MS
ECD BioGRID CCNF GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
ECD BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID C9orf78 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PRKN GeneID BioGRID Affinity Capture-MS
ECD BioGRID FAS GeneID BioGRID Proximity Label-MS
ECD BioGRID PHLPP1 GeneID BioGRID Proximity Label-MS
ECD BioGRID PTGES3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PRPF8 GeneID BioGRID Affinity Capture-MS; Co-fractionation; Proximity Label-MS; Reconstituted Complex
ECD BioGRID EFTUD2 GeneID BioGRID Affinity Capture-MS
ECD BioGRID DNAJC7 GeneID BioGRID Affinity Capture-MS
ECD BioGRID SNRPF GeneID BioGRID Affinity Capture-MS
ECD BioGRID SNRPD2 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PSMB10 GeneID BioGRID Affinity Capture-MS
ECD BioGRID MYO9B GeneID BioGRID Affinity Capture-MS
ECD BioGRID MYO1B GeneID BioGRID Affinity Capture-MS
ECD BioGRID KRAS GeneID BioGRID Negative Genetic
ECD BioGRID EGFR GeneID BioGRID Negative Genetic
ECD BioGRID vpr GeneID BioGRID Proximity Label-MS
ECD BioGRID LIPH GeneID BioGRID Affinity Capture-MS
ECD BioGRID AGO4 GeneID BioGRID Affinity Capture-MS
ECD BioGRID GPR156 GeneID BioGRID Affinity Capture-MS
ECD BioGRID SMYD4 GeneID BioGRID Affinity Capture-MS
ECD BioGRID TRIM52 GeneID BioGRID Affinity Capture-MS
ECD BioGRID WDR83 GeneID BioGRID Affinity Capture-MS
ECD BioGRID DUSP16 GeneID BioGRID Affinity Capture-MS
ECD BioGRID NAA40 GeneID BioGRID Proximity Label-MS
ECD BioGRID GPBP1L1 GeneID BioGRID Affinity Capture-MS
ECD BioGRID KIAA1143 GeneID BioGRID Affinity Capture-MS
ECD BioGRID EAPP GeneID BioGRID Affinity Capture-MS
ECD BioGRID TTC27 GeneID BioGRID Affinity Capture-MS
ECD BioGRID RBM38 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PCBP3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID AAR2 GeneID BioGRID Affinity Capture-MS
ECD BioGRID NCDN GeneID BioGRID Affinity Capture-MS
ECD BioGRID SNRNP200 GeneID BioGRID Affinity Capture-MS
ECD BioGRID POLR3G GeneID BioGRID Affinity Capture-MS
ECD BioGRID VTI1B GeneID BioGRID Affinity Capture-MS
ECD BioGRID TSSC4 GeneID BioGRID Affinity Capture-MS
ECD BioGRID SNRNP40 GeneID BioGRID Affinity Capture-MS
ECD BioGRID OASL GeneID BioGRID Affinity Capture-MS
ECD BioGRID RUVBL1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ECD BioGRID TPM3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID RPS9 GeneID BioGRID Affinity Capture-MS
ECD BioGRID MYH7 GeneID BioGRID Affinity Capture-MS
ECD BioGRID ZNHIT2 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
ECD BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
ECD BioGRID DNAJC1 GeneID BioGRID Proximity Label-MS
ECD BioGRID DNAJC17 GeneID BioGRID Affinity Capture-MS
ECD BioGRID DNAJC2 GeneID BioGRID Proximity Label-MS
ECD BioGRID NDN GeneID BioGRID Proximity Label-MS
ECD BioGRID HULC GeneID BioGRID Affinity Capture-MS
ECD BioGRID Rnf183 GeneID BioGRID Proximity Label-MS
ECD BioGRID HSCB GeneID BioGRID Affinity Capture-MS
ECD BioGRID TET2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
ECD BioGRID E6 GeneID BioGRID PCA; Two-hybrid
ECD BioGRID E6 GeneID BioGRID PCA
ECD BioGRID PINK1 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PTPN7 GeneID BioGRID Affinity Capture-MS
ECD BioGRID RAB27A GeneID BioGRID Affinity Capture-MS
ECD BioGRID GBF1 GeneID BioGRID Proximity Label-MS
ECD BioGRID RPS6KA2 GeneID BioGRID Proximity Label-MS
ECD BioGRID HOOK1 GeneID BioGRID Proximity Label-MS
ECD BioGRID HSPA8 GeneID BioGRID Proximity Label-MS
ECD BioGRID EZR GeneID BioGRID Proximity Label-MS
ECD BioGRID ZFP91 GeneID BioGRID Affinity Capture-Western
ECD BioGRID HNRNPF GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
ECD BioGRID MAPK6 GeneID BioGRID Affinity Capture-MS
ECD BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID RIPK4 GeneID BioGRID Affinity Capture-MS
ECD BioGRID DNAAF10 GeneID BioGRID Affinity Capture-MS
ECD BioGRID SLC7A6OS GeneID BioGRID Affinity Capture-MS
ECD BioGRID PRPF19 GeneID BioGRID Affinity Capture-MS
ECD BioGRID POLR1A GeneID BioGRID Affinity Capture-MS
ECD BioGRID ECD GeneID BioGRID Affinity Capture-MS
ECD BioGRID CD2BP2 GeneID BioGRID Affinity Capture-MS
ECD BioGRID SART3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID NONO GeneID BioGRID Affinity Capture-MS
ECD BioGRID PARP1 GeneID BioGRID Affinity Capture-MS
ECD BioGRID LYPD4 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PNKD GeneID BioGRID Affinity Capture-MS
ECD BioGRID CSNK2A1 GeneID BioGRID Biochemical Activity
ECD BioGRID PIH1D1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
ECD BioGRID ANAPC15 GeneID BioGRID Affinity Capture-MS
ECD BioGRID POC1A GeneID BioGRID Proximity Label-MS
ECD BioGRID MED12 GeneID BioGRID Affinity Capture-MS
ECD BioGRID KIAA0753 GeneID BioGRID Proximity Label-MS
ECD BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PDK3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID NPHP1 GeneID BioGRID Proximity Label-MS
ECD BioGRID GRIA2 GeneID BioGRID Affinity Capture-MS
ECD BioGRID CEP128 GeneID BioGRID Proximity Label-MS
ECD BioGRID CEP19 GeneID BioGRID Proximity Label-MS
ECD BioGRID CEP44 GeneID BioGRID Proximity Label-MS
ECD BioGRID CEP63 GeneID BioGRID Proximity Label-MS
ECD BioGRID RPGRIP1 GeneID BioGRID Proximity Label-MS
ECD BioGRID AHI1 GeneID BioGRID Proximity Label-MS
ECD BioGRID MED4 GeneID BioGRID Proximity Label-MS
ECD BioGRID Myh10 GeneID BioGRID Affinity Capture-MS
ECD BioGRID Ruvbl1 GeneID BioGRID Affinity Capture-MS
ECD BioGRID Mcm2 GeneID BioGRID Affinity Capture-MS
ECD BioGRID Junb GeneID BioGRID Affinity Capture-MS
ECD BioGRID GCFC2 GeneID BioGRID Affinity Capture-MS
ECD BioGRID PTGER3 GeneID BioGRID Affinity Capture-MS
ECD BioGRID TXNIP GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ECD BioGRID TP53 GeneID BioGRID Affinity Capture-Western
ECD BioGRID PSMD2 GeneID BioGRID Co-fractionation
ECD BioGRID PSMD1 GeneID BioGRID Co-fractionation
ECD BioGRID PSMC5 GeneID BioGRID Co-fractionation
ECD BioGRID PSMC3 GeneID BioGRID Co-fractionation
ECD BioGRID PSEN2 GeneID BioGRID Two-hybrid
ECD BioGRID Prpf8 GeneID BioGRID Affinity Capture-MS
ECD BioGRID EWSR1 GeneID BioGRID Two-hybrid
ECD Protein NR3C1 GeneID HPRD
ECD BioGRID NR3C1 GeneID BioGRID Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
ECD SGTA 0 0 217 270 1 1
ECD CTR9 0 0 0 152 1 1
ECD TSSC4 838 0 0 870 1 1
ECD TNK2 0 0 322 321 1 1
ECD EP300 0 0 60 280 1 2
ECD DPT 0 0 72 272 1 1
ECD ZCCHC14 0 0 0 157 1 1
ECD CPTP 0 0 0 213 1 1
ECD FKBP5 0 0 288 288 1 1
ECD LGALS4 0 0 150 203 1 1
ECD NR3C1 192 0 261 404 1 1
ECD VPS52 0 0 181 266 1 1
ECD NFIC 0 900 0 904 1 1
ECD AKAP13 0 0 0 321 1 1
ECD COX6A2 0 0 0 260 1 1
ECD URI1 0 0 91 265 1 1
ECD RUVBL1 270 0 44 272 1 1
ECD TRAF6 0 900 0 900 1 2
ECD AAR2 877 0 0 937 1 1
ECD XPO5 0 0 91 333 1 1
ECD KIAA1143 497 0 0 497 1 1
ECD SNRPN 0 0 0 185 1 1
ECD CRHR1 0 0 166 165 1 1
ECD SNRPD2 0 0 0 159 1 1
ECD XYLT1 0 0 181 181 1 1
ECD ZFP36 0 0 103 164 1 1
ECD SRF 0 0 213 213 1 1
ECD ETV1 0 0 0 223 1 1
ECD ZFP91 270 0 91 319 1 1
ECD ITGB1BP2 0 0 0 181 1 1
ECD RPL3 0 0 154 384 1 1
ECD FKBP3 0 0 75 186 1 1
ECD MED12 198 0 0 198 1 1
ECD ZBED4 0 0 0 154 1 1
ECD PSMD1 611 0 0 611 1 1
ECD NCBP1 0 0 152 172 1 1
ECD MLKL 0 0 103 151 1 2
ECD RPAP3 270 0 0 430 1 1
ECD PARP1 270 0 0 270 1 2
ECD MBD3 0 0 0 170 1 1
ECD HSPA8 83 0 120 158 1 2
ECD ZCCHC2 0 0 0 157 1 1
ECD FOXG1 0 0 181 181 1 1
ECD HNRNPF 270 0 145 349 1 1
ECD ACAA2 0 0 64 207 1 1
ECD SART3 270 0 0 306 1 1
ECD COX6B1 0 0 180 179 1 1
ECD MFAP1 0 0 113 656 1 1
ECD NR1H3 0 0 0 366 1 1
ECD CNBP 0 0 52 465 1 1
ECD CRHBP 0 0 206 206 1 1
ECD FGGY 0 0 0 205 1 1
ECD XPO1 0 0 163 287 1 1
ECD EFTUD1 0 0 0 201 1 1
ECD DMTN 0 0 75 448 1 1
ECD UROC1 0 0 127 492 1 1
ECD GPR1 0 0 234 234 1 1
ECD SMARCAD1 0 0 0 247 1 1
ECD NAT10 0 0 0 167 1 1
ECD SORT1 0 900 0 900 1 1
ECD GCFC2 130 0 0 232 1 1
ECD CCNC 0 0 46 176 1 1
ECD NFYB 0 0 248 248 1 1
ECD NPAS2 0 0 108 155 1 1
ECD NUDT3 0 0 90 230 1 1
ECD MSC 0 0 232 231 1 1
ECD SHPK 0 0 0 205 1 1
ECD CREBBP 0 0 0 175 1 1
ECD GRIA2 151 0 0 150 1 1
ECD REPIN1 0 0 349 359 1 1
ECD LANCL2 0 0 653 653 1 1
ECD MOGS 0 0 181 181 1 1
ECD SLC7A6OS 270 0 0 270 1 1
ECD PRPF38A 0 0 102 580 1 1
ECD NR2C1 0 0 0 181 1 1
ECD ZNF274 0 900 0 901 1 1
ECD LRP3 0 0 112 205 1 1
ECD PGA5 0 0 194 194 1 1
ECD ANAPC15 226 0 0 225 1 1
ECD EFTUD2 398 0 0 569 1 1
ECD ALOX12 0 0 43 209 1 1
ECD MRGPRG 0 0 365 365 1 1
ECD NFIX 0 0 136 166 1 1
ECD ENSG00000272772 0 0 0 187 1 1
ECD LNPEP 0 0 60 263 1 1
ECD MBD2 0 0 0 170 1 1
ECD GK2 0 0 0 205 1 1
ECD CD2BP2 270 0 0 410 1 1
ECD TP53 270 0 120 416 1 2
ECD NR1H2 0 0 0 366 1 1
ECD VPS4B 0 0 234 234 1 1
ECD KIF15 0 0 210 237 1 1
ECD HSCB 270 0 0 270 1 1
ECD CHN1 0 0 72 218 1 1
ECD MED29 0 0 171 171 1 1
ECD DDAH2 0 0 157 189 1 1
ECD PRPF31 0 0 57 553 1 1
ECD MKRN1 0 0 194 268 1 1
ECD NFIA 0 0 112 203 1 1
ECD TTC27 270 0 0 309 1 1
ECD NOSTRIN 0 0 246 245 1 1
ECD RPS20 0 0 150 536 1 1
ECD NME8 0 0 0 196 1 1
ECD C12orf5 0 0 123 258 1 1
ECD PSMC3 616 0 0 616 1 1
ECD NGFR 0 900 0 900 1 1
ECD SARNP 0 0 82 428 1 1
ECD VTI1B 242 0 0 241 1 2
ECD RET 0 0 0 417 1 1
ECD TRIM26 0 0 75 217 1 1
ECD RXRG 0 0 0 296 1 1
ECD SNRNP40 858 0 0 858 1 1
ECD GFRA1 0 0 0 220 1 1
ECD RBPJ 0 0 241 240 1 1
ECD CPEB1 0 0 123 183 1 1
ECD TET2 270 0 0 270 1 2
ECD KTI12 0 0 170 189 1 1
ECD ADAM17 0 900 0 900 1 1
ECD CHMP6 0 0 173 173 1 1
ECD GUCY2C 0 0 164 216 1 1
ECD HNRNPK 0 0 90 634 1 1
ECD VTN 0 0 0 260 1 1
ECD TBP 0 0 0 160 1 1
ECD NONO 270 0 0 270 1 1
ECD OSBP 0 0 0 430 1 1
ECD PSMC5 616 0 0 647 1 1
ECD YIPF1 0 0 46 247 1 1
ECD ILKAP 0 0 283 382 1 1
ECD YAP1 0 0 238 256 1 2
ECD MYBL2 0 0 103 159 1 1
ECD PSMD2 615 0 0 615 1 1
ECD RXRB 0 0 0 296 1 1
ECD TBPL1 0 0 90 153 1 1
ECD PSMD9 0 0 213 213 1 1
ECD RPL3L 0 0 0 183 1 1
ECD FBXL19 0 0 0 150 1 1
ECD SNRNP200 688 0 57 894 1 1
ECD TAS1R3 0 0 145 597 1 1
ECD LANCL1 0 0 560 560 1 1
ECD PNKD 212 0 0 212 1 1
ECD RXRA 0 0 0 296 1 1
ECD GK5 0 0 0 205 1 1
ECD POLR1A 270 0 0 270 1 1
ECD WDR92 270 0 0 418 1 1
ECD GK 0 0 0 205 1 1
ECD COX6A1 0 0 172 255 1 1
ECD NME2 0 0 167 597 1 1
ECD NR2C2 0 0 0 181 1 1
ECD SKP1 0 0 74 214 1 2
ECD ACD 0 0 0 642 1 2
ECD HAP1 0 0 188 188 1 1
ECD RB1 270 0 0 270 1 2
ECD GFM1 0 0 0 201 1 1
ECD LANCL3 0 0 391 390 1 1
ECD HFM1 0 0 74 353 1 1
ECD GUCA1A 0 0 182 307 1 1
ECD ZNHIT2 748 0 0 775 1 1
ECD GATM 0 0 52 261 1 1
ECD NME1-NME2 0 0 171 599 1 1
ECD GLTPD2 0 0 0 213 1 1
ECD RAE1 0 0 70 200 1 1
ECD SKI 0 0 288 288 1 1
ECD RPL35 0 0 0 264 1 1
ECD PDK3 226 0 0 236 1 1
ECD GMFG 0 0 260 546 1 1
ECD NFYC 0 0 154 153 1 1
ECD PIH1D1 678 0 95 736 1 1
ECD BCAS2 0 0 82 570 1 1
ECD RNF4 0 0 0 213 1 1
ECD NR4A2 0 0 0 188 1 1
ECD BDNF 0 900 66 902 1 2
ECD EAPP 751 0 0 751 1 1
ECD NME1 0 0 0 426 1 1
ECD OSBP2 0 0 0 239 1 1
ECD EEF2 0 0 0 214 1 2
ECD POU2F1 0 0 235 235 1 1
ECD TXNIP 270 0 0 270 1 2
ECD GMFB 0 0 0 304 1 1
ECD CSNK2A1 270 0 0 270 1 1
ECD SHROOM2 0 0 260 306 1 1
ECD NCBP2 0 0 213 213 1 1
ECD PRPF8 873 0 0 918 1 1
ECD STARD3 0 0 0 256 1 1
ECD ASCC3 0 0 0 330 1 1
ECD PRPF19 270 0 0 270 1 1
ECD ENSG00000257390 0 0 0 403 1 1
ECD ENSG00000273171 0 0 0 260 1 1
ECD CHORDC1 0 0 0 154 1 1
ECD PAXBP1 0 0 0 167 1 1
ECD MRGBP 0 0 242 241 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0035035 Molecular Function histone acetyltransferase binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0008380 Biological Process RNA splicing involved_in IEA
GO:0048144 Biological Process fibroblast proliferation involved_in IEA
GO:0006397 Biological Process mRNA processing involved_in IEA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:2000045 Biological Process regulation of G1/S transition of mitotic cell cycle involved_in IEA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus located_in IDA
Pathways
Name DB ID
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_024203 1 miscRNA transcript variant 4 NC_000010 Reference
NM_007265 3 mRNA transcript variant 1 NC_000010 Reference
NM_001135753 1 mRNA transcript variant 3 NC_000010 Reference
NM_001135752 1 mRNA transcript variant 2 NC_000010 Reference