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CGAS

cyclic GMP-AMP synthase
General Information
Name cyclic GMP-AMP synthase
Alias
  • cyclic GMP-AMP synthase
  • 2'3'-cGAMP synthase
  • DANGER family member 4
  • Mab-21 domain containing 1
  • cGAMP synthase
  • mab-21 domain-containing protein 1
  • protein MB21D1
Gene_family
organism Homo sapiens
entrez_id 115004
location 6q13
transcript_count 2
exon_count 5
Location
by NCBI GRCh38.p14
Summary
    Entrez Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]
    nextProt Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:24077100, PubMed:25131990, PubMed:23707061, PubMed:23722159, PubMed:29976794, PubMed:30799039, PubMed:21478870, PubMed:23707065, PubMed:24116191, PubMed:24462292, PubMed:32814054, PubMed:33273464, PubMed:26300263, PubMed:33542149, PubMed:31142647). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:33230297, PubMed:32817552, PubMed:33606975, PubMed:35438208, PubMed:35460603, PubMed:35322803). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:31299200, PubMed:28738408, PubMed:28759889, PubMed:33230297, PubMed:33031745). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:31299200, PubMed:28738408, PubMed:28759889, PubMed:33230297, PubMed:33031745, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:33542149, PubMed:33051594, PubMed:32911482, PubMed:32912999). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
CGAS BioGRID PRNP GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FOXO1 GeneID BioGRID Proximity Label-MS
CGAS BioGRID MARCHF8 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
CGAS BioGRID PRKN GeneID BioGRID Affinity Capture-MS
CGAS BioGRID USP7 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
CGAS BioGRID RAC3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SERPINB5 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID USP29 GeneID BioGRID Affinity Capture-Western
CGAS BioGRID USP25 GeneID BioGRID Affinity Capture-Western
CGAS BioGRID NUPR1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHMP4C GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CIT GeneID BioGRID Affinity Capture-MS
CGAS BioGRID KIF20A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PRC1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID USP27X GeneID BioGRID Affinity Capture-Western
CGAS BioGRID HSPA4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID BLVRA GeneID BioGRID Affinity Capture-MS
CGAS BioGRID HSPA4L GeneID BioGRID Affinity Capture-MS
CGAS BioGRID HSPH1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID GBF1 GeneID BioGRID Proximity Label-MS
CGAS BioGRID STING1 GeneID BioGRID Affinity Capture-Western
CGAS BioGRID H2BC21 GeneID BioGRID Affinity Capture-Western
CGAS BioGRID NR2C2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IFI16 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
CGAS BioGRID BRCA1 GeneID BioGRID Affinity Capture-Western
CGAS BioGRID RBX1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
CGAS BioGRID Trim56 GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
CGAS BioGRID CGAS GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS
CGAS BioGRID TRIM56 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
CGAS BioGRID MYC GeneID BioGRID Affinity Capture-MS
CGAS BioGRID US1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL54 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL49 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL48 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL47 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL46 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL19 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL18 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL40 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL39 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL38 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UL37 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CDK11A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RPL7L1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RPL22L1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID APOBEC3F GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TXLNA GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DHX36 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DTX3L GeneID BioGRID Affinity Capture-MS
CGAS BioGRID BROX GeneID BioGRID Affinity Capture-MS
CGAS BioGRID APOBEC3D GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHMP4B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IKBIP GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FTSJ3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LACTB GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LARP4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DDX60L GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DHX57 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PIP4P1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ZNF622 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID HELZ2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ZCCHC3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LTV1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ZNF512 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID C7orf50 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LLPH GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ASCC2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID GRWD1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PARP9 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ZNF93 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SKIC8 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPL24 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS34 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPL38 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPL41 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS5 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS9 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TRIM26 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TRIM25 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UBTF GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TUBG1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TSG101 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID THBS1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TGM2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID VAMP7 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SURF6 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SRP72 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SRP68 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FSCN1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SMARCA1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SLC25A1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SLC12A4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SKIC2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SH3GL1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SDCBP GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SDC4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RRBP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ABCE1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RNH1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UPF1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RAD23B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RAB5C GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RAB3B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PURB GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PURA GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PPP6C GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PDGFRA GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHMP1A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID OAS2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
CGAS BioGRID NEDD4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MYO5A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MYO1C GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MX2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MX1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MMP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MBD1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MAP1A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MAGOH GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LGALS9 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LGALS1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID KTN1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID KIF2A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ILK GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IGHMBP2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CCN1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IFIT3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IFIT1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IFIT2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID HSPB1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID HLA-B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID H1-0 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID GNB2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID GJA1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FN1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FMR1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FLOT2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID F2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID STOM GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CTSK GeneID BioGRID Affinity Capture-MS
CGAS BioGRID COL6A3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CNP GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CLCN7 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHD2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHD1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CENPB GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CAMK2D GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ASPH GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ANXA6 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ANXA5 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ANXA1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS15 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS26 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID YTHDC2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID NMNAT1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PARP12 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS25 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FAM111A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID APOBEC3G GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS35 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID WDFY1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID WDR18 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPL47 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID POGLUT1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS22 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PNO1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ZC3HAV1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID NKRF GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TSR1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MAP7D1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DDX27 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LYAR GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DDX60 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PIP4P2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MACROH2A2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LSG1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UEVLD GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ARL8B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SDAD1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RBM28 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PLEKHB2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PTCD3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LAMTOR1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TOR4A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHMP3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS23 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LARP7 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ZCCHC17 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID VTA1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHMP5 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID NOP16 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ANKFY1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS17 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID HERC5 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID VPS28 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRTO4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS7 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ASCC1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID EHD2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID EHD4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SEC61A1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID NOB1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS18B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DCPS GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS28 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID APOBEC3C GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHMP2A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID VPS4A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ZBTB11 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID STAU2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PELP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID AP3M1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID GREM1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MYOF GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RAI14 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SPATS2L GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CHMP2B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PES1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CAPN7 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID UFL1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DNAJC13 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ANKRD28 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SULF1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RRS1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FAM120A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CYFIP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS27 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MYCBP2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RBM34 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MAPRE1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RALY GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PWP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID KRR1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TRIOBP GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IMMT GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RAB32 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ASCC3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
CGAS BioGRID POP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TUBGCP2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID NES GeneID BioGRID Affinity Capture-MS
CGAS BioGRID CTCF GeneID BioGRID Affinity Capture-MS
CGAS BioGRID APPBP2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ECI2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID NSA2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IFITM3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MRPS31 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID FLOT1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PARP2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PDCD6IP GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MVP GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TRIM14 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID IST1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SKIC3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MACROH2A1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID VPS4B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TRIP4 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID USP10 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID BAZ1B GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TAX1BP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SQSTM1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID OASL GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PRKRA GeneID BioGRID Affinity Capture-MS
CGAS BioGRID AP3B1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID SMARCA5 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TFPI2 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RAB7A GeneID BioGRID Affinity Capture-MS
CGAS BioGRID DAP3 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LUZP1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID TRIM41 GeneID BioGRID Affinity Capture-Western
CGAS BioGRID NKX2-1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID RNF185 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
CGAS BioGRID ZNF593 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID Espl1 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID Mus81 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID LDHD GeneID BioGRID Affinity Capture-MS
CGAS BioGRID MPHOSPH8 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID PHF8 GeneID BioGRID Affinity Capture-MS
CGAS BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
StringDB
A B experiments database textmining combined score hadb nhadb
MB21D1 ULK1 0 0 295 295 2 1
MB21D1 MAP1LC3B 0 0 181 181 2 1
MB21D1 ISG15 0 0 560 586 2 1
MB21D1 IRF1 0 0 520 544 2 1
MB21D1 ATG5 0 0 325 325 2 1
MB21D1 CALCOCO2 0 0 392 392 2 1
MB21D1 HMGB1 0 0 372 372 2 1
MB21D1 PDCD1 0 0 261 261 2 1
MB21D1 OPTN 0 0 294 294 2 1
MB21D1 NFKBIA 0 0 284 284 2 1
MB21D1 SYK 0 0 171 171 2 1
MB21D1 DNM1L 0 0 161 161 2 1
MB21D1 NAMPT 0 0 140 374 2 1
MB21D1 IL10 0 0 360 374 2 1
MB21D1 ATG7 0 0 210 210 2 1
MB21D1 ATM 0 0 360 361 2 1
MB21D1 CASP4 0 0 125 225 2 1
MB21D1 CDKN2A 0 0 193 193 2 1
MB21D1 ATG16L1 0 0 276 276 2 1
MB21D1 NOD2 0 0 451 451 2 1
MB21D1 RIPK1 0 0 293 293 2 1
MB21D1 REL 0 0 150 174 2 1
MB21D1 NLRP3 0 0 656 656 2 1
MB21D1 IL33 0 0 163 163 2 1
MB21D1 CXCL1 0 0 216 216 2 1
MB21D1 CASP3 0 0 260 260 2 1
MB21D1 IL13 0 0 163 163 2 1
MB21D1 ATG12 0 0 212 212 2 1
MB21D1 CYBB 0 0 157 156 2 1
MB21D1 BECN1 0 0 988 988 2 1
MB21D1 TRAF3 0 0 458 457 2 1
MB21D1 TLR2 0 0 470 479 2 1
MB21D1 NOD1 0 0 325 325 2 1
MB21D1 KRAS 0 0 125 169 2 1
MB21D1 IRF3 0 0 856 856 2 1
MB21D1 PYCARD 0 0 358 384 2 1
MB21D1 TLR9 0 0 684 711 2 1
MB21D1 CXCL10 0 0 529 568 2 1
MB21D1 PINK1 0 0 218 218 2 1
MB21D1 NLRC4 0 0 390 390 2 1
MB21D1 IKBKB 0 0 337 337 2 1
MB21D1 CD4 0 0 460 459 2 1
MB21D1 AKT1 0 0 260 260 2 1
MB21D1 RIPK3 0 0 253 252 2 1
MB21D1 EIF2S1 0 0 202 202 2 1
MB21D1 JAK1 0 0 380 380 2 1
MB21D1 FOXP3 0 0 210 210 2 1
MB21D1 TBK1 0 0 904 907 2 1
MB21D1 TLR3 0 0 653 660 2 1
MB21D1 ATG3 0 0 139 156 2 1
MB21D1 CD47 0 0 232 231 2 1
MB21D1 CD274 0 0 460 471 2 1
MB21D1 ATR 0 0 150 168 2 1
MB21D1 RPS6KB1 0 0 172 187 2 1
MB21D1 CDK1 0 0 150 188 2 1
MB21D1 PRKDC 0 0 236 236 2 1
MB21D1 CANX 0 0 125 157 2 1
MB21D1 BLM 0 0 73 284 2 1
MB21D1 CTLA4 0 0 367 367 2 1
MB21D1 PPP1R15A 0 0 135 198 2 1
MB21D1 USP14 0 0 320 319 2 1
MB21D1 TANK 0 0 499 499 2 1
MB21D1 TNF 0 0 467 494 2 1
MB21D1 NBR1 0 0 195 195 2 1
MB21D1 RAB7A 0 0 167 167 2 1
MB21D1 DRAM1 0 0 81 163 2 1
MB21D1 CD63 0 0 134 152 2 1
MB21D1 TUFM 0 0 194 194 2 1
MB21D1 P2RX7 0 0 242 241 2 1
MB21D1 CCR2 0 0 177 177 2 1
MB21D1 TLR7 0 0 610 620 2 1
MB21D1 CYCS 0 0 181 181 2 1
MB21D1 TRAF6 0 0 400 400 2 1
MB21D1 IL17A 0 0 234 234 2 1
MB21D1 EP300 0 0 165 165 2 1
MB21D1 CCL2 0 0 302 302 2 1
MB21D1 CASP8 0 0 251 279 2 1
MB21D1 ALB 0 0 207 223 2 1
MB21D1 MAVS 0 0 759 782 2 1
MB21D1 AIM2 0 0 759 778 2 1
MB21D1 AGER 0 0 203 203 2 1
MB21D1 ATG9A 0 0 340 342 2 1
MB21D1 PARP1 0 0 181 181 2 1
MB21D1 MLKL 0 0 275 313 2 1
MB21D1 ICAM1 0 0 181 204 2 1
MB21D1 FBXW7 0 0 54 153 2 1
MB21D1 MUL1 0 0 204 204 2 1
MB21D1 ACTB 0 0 369 380 2 1
MB21D1 NLRX1 0 0 392 392 2 1
MB21D1 CD40 0 0 252 252 2 1
MB21D1 SQSTM1 0 0 297 297 2 1
MB21D1 CASP1 0 0 595 625 2 1
MB21D1 CHEK1 0 0 212 212 2 1
MB21D1 JUN 0 0 167 167 2 1
MB21D1 TICAM1 0 0 464 463 2 1
MB21D1 EIF2AK2 0 0 261 322 2 1
MB21D1 MFN1 0 0 232 231 2 1
MB21D1 TFAM 270 0 390 535 2 1
MB21D1 RIPK2 0 0 245 261 2 1
MB21D1 ANXA5 0 0 144 162 2 1
MB21D1 LRSAM1 0 0 134 178 2 1
MB21D1 CCL5 0 0 391 423 2 1
MB21D1 GSDMD 0 0 467 481 2 1
MB21D1 IFNG 0 0 170 354 2 1
MB21D1 ATG14 0 0 166 165 2 1
MB21D1 GAPDH 0 0 337 354 2 1
MB21D1 TLR4 0 0 519 522 2 1
MB21D1 PML 0 0 234 234 2 1
MB21D1 RELA 0 0 229 234 2 1
MB21D1 MFN2 0 0 183 183 2 1
MB21D1 HRAS 0 0 157 163 2 1
MB21D1 CTNNB1 0 0 160 159 2 1
MB21D1 IL1B 0 0 529 550 2 1
MB21D1 HIF1A 0 0 162 161 2 1
MB21D1 CXCL8 0 0 294 311 2 1
MB21D1 IL6 0 0 503 504 2 1
MB21D1 PIK3C3 0 0 235 235 2 1
MB21D1 STAT1 0 0 556 571 2 1
MB21D1 CXCR4 0 0 170 169 2 1
MB21D1 MTOR 0 0 214 214 2 1
MB21D1 RAD51 0 0 209 209 2 1
MB21D1 CAMP 0 0 279 279 2 1
MB21D1 LMNA 0 0 170 169 2 1
MB21D1 TP53 0 0 323 323 2 1
MB21D1 CFLAR 0 0 134 156 2 1
MB21D1 EGFR 0 0 155 154 2 1
MB21D1 MYD88 0 0 600 627 2 1
MB21D1 FADD 0 0 170 174 2 1
MB21D1 LAMP1 0 0 230 229 2 1
MB21D1 MCOLN1 0 0 0 189 2 1
MB21D1 STAT3 0 0 260 260 2 1
MB21D1 EIF2AK4 0 0 139 156 2 1
MB21D1 JAK2 0 0 155 154 2 1
MB21D1 IL18 0 0 505 513 2 1
MB21D1 MYC 66 0 240 259 2 1
MB21D1 IRGM 0 0 218 218 2 1
MB21D1 TAB2 0 0 184 183 2 1
MB21D1 CD80 0 0 282 282 2 1
MB21D1 BRCA1 270 0 260 449 2 1
MB21D1 TAX1BP1 0 0 265 265 2 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0061501 Molecular Function 2',3'-cyclic GMP-AMP synthase activity enables EXP
GO:0061501 Molecular Function 2',3'-cyclic GMP-AMP synthase activity enables IBA
GO:0061501 Molecular Function 2',3'-cyclic GMP-AMP synthase activity enables IDA
GO:0005524 Molecular Function ATP binding enables IEA
GO:0003677 Molecular Function DNA binding enables IDA
GO:0005525 Molecular Function GTP binding enables IEA
GO:0003682 Molecular Function chromatin binding enables IBA
GO:0003682 Molecular Function chromatin binding enables IDA
GO:0003690 Molecular Function double-stranded DNA binding enables IBA
GO:0003690 Molecular Function double-stranded DNA binding enables IDA
GO:0046872 Molecular Function metal ion binding enables IEA
GO:0140693 Molecular Function molecular condensate scaffold activity enables IDA
GO:0031491 Molecular Function nucleosome binding enables IDA
GO:0005546 Molecular Function phosphatidylinositol-4,5-bisphosphate binding enables IDA
GO:0160004 Molecular Function poly-ADP-D-ribose modification-dependent protein binding enables ISS
GO:0005515 Molecular Function protein binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0006974 Biological Process DNA damage response involved_in IBA
GO:0006974 Biological Process DNA damage response involved_in IDA
GO:0006281 Biological Process DNA repair involved_in IEA
GO:0002218 Biological Process activation of innate immune response involved_in IBA
GO:0002218 Biological Process activation of innate immune response involved_in IDA
GO:0002218 Biological Process activation of innate immune response involved_in IMP
GO:0019933 Biological Process cAMP-mediated signaling involved_in IDA
GO:0140896 Biological Process cGAS/STING signaling pathway involved_in IDA
GO:0019934 Biological Process cGMP-mediated signaling involved_in IDA
GO:0071360 Biological Process cellular response to exogenous dsRNA involved_in IBA
GO:0002753 Biological Process cytoplasmic pattern recognition receptor signaling pathway involved_in IDA
GO:0051607 Biological Process defense response to virus involved_in IDA
GO:0008340 Biological Process determination of adult lifespan involved_in IEA
GO:0045087 Biological Process innate immune response involved_in IDA
GO:0160049 Biological Process negative regulation of cGAS/STING signaling pathway involved_in IDA
GO:2000042 Biological Process negative regulation of double-strand break repair via homologous recombination involved_in IBA
GO:2000042 Biological Process negative regulation of double-strand break repair via homologous recombination involved_in IDA
GO:0038001 Biological Process paracrine signaling involved_in IBA
GO:0038001 Biological Process paracrine signaling involved_in IDA
GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in IDA
GO:2000774 Biological Process positive regulation of cellular senescence involved_in ISS
GO:0002230 Biological Process positive regulation of defense response to virus by host involved_in IBA
GO:0002230 Biological Process positive regulation of defense response to virus by host involved_in IDA
GO:0002230 Biological Process positive regulation of defense response to virus by host involved_in IMP
GO:0032481 Biological Process positive regulation of type I interferon production involved_in IBA
GO:0032481 Biological Process positive regulation of type I interferon production involved_in IDA
GO:0032481 Biological Process positive regulation of type I interferon production involved_in TAS
GO:0050863 Biological Process regulation of T cell activation involved_in IEA
GO:0002637 Biological Process regulation of immunoglobulin production involved_in IEA
GO:0005737 Cellular Component cytoplasm is_active_in IDA
GO:0005829 Cellular Component cytosol is_active_in IBA
GO:0005829 Cellular Component cytosol is_active_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0016604 Cellular Component nuclear body located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0035861 Cellular Component site of double-strand break is_active_in IBA
GO:0035861 Cellular Component site of double-strand break located_in IDA
Pathways
Name DB ID
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
STING mediated induction of host immune responses Reactome R-HSA-1834941
Cytosolic sensors of pathogen-associated DNA Reactome R-HSA-1834949
STING pathway in Kawasaki-like disease and COVID-19 (WP4961) WikiPathways WP4961_r123345
Mitochondrial immune response to SARS-CoV-2 (WP5038) WikiPathways WP5038_r124641
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
Pathways of nucleic acid metabolism and innate immune sensing (WP4705) WikiPathways WP4705_r123423
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001410911 1 mRNA transcript variant 2 NC_000006 Reference
NM_138441 3 mRNA transcript variant 1 NC_000006 Reference