CLN3

CLN3 lysosomal/endosomal transmembrane protein, battenin
General Information
Name CLN3 lysosomal/endosomal transmembrane protein, battenin
Alias
  • battenin
  • CLN3, battenin
  • batten disease protein
  • ceroid-lipofuscinosis, neuronal 3
Synonyms JNCL BTN1 BTS
Gene_family None
organism Homo sapiens
entrez_id 1201
location 16p12.1
transcript_count 6
exon_count 16
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
      Stringdb Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes
      nextProt Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10924275, PubMed:18817525, PubMed:18317235, PubMed:22261744, PubMed:15471887, PubMed:20850431). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:10924275, PubMed:18817525). Moreover regulates CTSD activity in response to osmotic stress (PubMed:23840424, PubMed:28390177). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:18317235). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:20850431). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (By similarity). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (By similarity). Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:17482562).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    CLN3 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
    CLN3 BioGRID TMPRSS11B GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TPRA1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID LRRC25 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC22A9 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID GLMP GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ARMC6 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID OPALIN GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID AGPAT2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID B3GALT4 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID DNAH17 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID VIPR2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SYP GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID P2RY2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID OPRL1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID LGALS9 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID HLA-B GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID GRPR GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID MLNR GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID GP5 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID GCGR GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID FUCA2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID C5AR1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID NPC1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID RARS2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID B3GALT2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID PTH1R GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A3 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID FADS2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID DPM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    CLN3 BioGRID CDS2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A11 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID UQCRC2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TFRC GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SSR4 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID RPN2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID RPN1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID RCN2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID PRKDC GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID EMD GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID DDOST GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID DBH GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A10 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    CLN3 BioGRID CSE1L GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID CPT1A GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID COX15 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID CALU GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID AUP1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ATP2A2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ATP1A1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ARF5 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ARF4 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ARF3 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A6 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A5 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A4 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC35B2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID MICOS13 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SFXN1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID FAR1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SFXN3 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A22 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID STRA6 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID XPO5 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TMEM33 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID HACD3 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID HSD17B12 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID KCNIP3 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    CLN3 BioGRID SEC61A1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    CLN3 BioGRID PHGDH GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SAMM50 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID FKBP8 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ECPAS GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ADGRL2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID NUP205 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ERLIN2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID IMMT GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID GCN1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ATP5MG GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SLC25A13 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SCAMP3 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID LPGAT1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TECR GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
    CLN3 BioGRID GEMIN4 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID GANAB GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID XPOT GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID DDX20 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ILVBL GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID CKAP4 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID AFG3L2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ATG7 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SIGMAR1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TELO2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID NUP93 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID NPEPPS GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TRIP13 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID VDAC2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID TMPO GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ABCD3 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID PHB1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID IRAK1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID CYC1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SFXN4 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID ESYT2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID CCDC47 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID UNC45A GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID CAND1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID FANCI GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID RIF1 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SEC61A2 GeneID BioGRID Affinity Capture-MS
    CLN3 BioGRID SBDS GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    CLN3 SPATA7 0 0 339 339 1 1
    CLN3 OXNAD1 0 0 0 155 1 1
    CLN3 CHKA 0 0 181 217 1 1
    CLN3 ACAP3 0 0 162 182 1 1
    CLN3 TUFM 0 0 236 460 1 1
    CLN3 KCTD7 0 0 710 752 1 1
    CLN3 HSPA6 0 0 159 191 1 1
    CLN3 KDM2A 0 0 0 180 1 1
    CLN3 CYB5R1 0 0 0 155 1 1
    CLN3 KCTD9 0 0 0 185 1 1
    CLN3 IMPDH1 0 0 108 244 1 1
    CLN3 IPO11 0 0 0 154 1 1
    CLN3 PRKAB1 0 0 57 160 1 2
    CLN3 MAPK8 0 0 75 192 1 2
    CLN3 TMEM2 0 0 90 248 1 1
    CLN3 HGSNAT 0 0 343 412 1 1
    CLN3 SORCS2 0 0 57 159 1 1
    CLN3 SBDS 192 0 432 629 1 1
    CLN3 CDC6 0 0 170 169 1 1
    CLN3 AIFM2 0 0 90 190 1 1
    CLN3 PAICS 0 0 166 165 1 1
    CLN3 ACP2 0 0 370 377 1 1
    CLN3 TREH 0 0 0 276 1 1
    CLN3 ATG4A 0 0 181 223 1 2
    CLN3 MFSD9 0 0 230 396 1 1
    CLN3 IMMT 423 0 0 422 1 1
    CLN3 GCN1L1 473 0 0 525 1 1
    CLN3 MAN2B2 0 0 46 182 1 1
    CLN3 CHEK2 0 0 70 170 1 1
    CLN3 LCA5 0 0 245 244 1 1
    CLN3 LHX8 0 0 0 151 1 1
    CLN3 PDE6B 0 0 170 169 1 1
    CLN3 PSMD4 0 0 150 235 1 1
    CLN3 XPO5 270 0 0 270 1 1
    CLN3 MYCL 0 0 398 398 1 1
    CLN3 DHDDS 0 0 155 154 1 1
    CLN3 CSE1L 270 0 0 298 1 1
    CLN3 MFSD2A 0 0 74 157 1 1
    CLN3 LHX5 0 0 0 173 1 1
    CLN3 ACSF3 0 0 117 170 1 1
    CLN3 TRIP13 129 0 0 152 1 1
    CLN3 CTSH 0 0 435 445 1 1
    CLN3 MFSD5 0 0 324 435 1 1
    CLN3 HOOK1 0 0 807 827 1 1
    CLN3 CTNS 0 0 414 527 1 1
    CLN3 NYX 0 0 167 181 1 1
    CLN3 TMEM180 0 0 194 486 1 1
    CLN3 ENSG00000239789 0 0 113 224 1 1
    CLN3 MRPL41 0 0 42 184 1 1
    CLN3 HESX1 0 0 0 151 1 1
    CLN3 GNB2 0 0 0 162 1 1
    CLN3 SORCS3 0 0 57 151 1 1
    CLN3 CD68 0 0 124 162 1 1
    CLN3 CASP8 0 0 123 159 1 2
    CLN3 SLC2A13 0 0 0 203 1 1
    CLN3 TBCK 0 0 124 197 1 1
    CLN3 GPR98 0 0 176 175 1 1
    CLN3 DRAM2 0 0 202 237 1 2
    CLN3 NRDE2 0 0 0 158 1 1
    CLN3 TECR 270 0 0 301 1 1
    CLN3 FAM161A 0 0 138 161 1 1
    CLN3 SLC17A6 0 0 0 179 1 1
    CLN3 SLC30A1 0 0 0 187 1 1
    CLN3 MFSD3 0 0 180 351 1 1
    CLN3 ARSG 0 0 293 400 1 1
    CLN3 PLD3 0 0 107 182 1 1
    CLN3 CALU 270 0 0 270 1 1
    CLN3 ARHGAP21 0 0 170 220 1 1
    CLN3 ADD3 0 0 134 191 1 1
    CLN3 AUP1 385 0 0 405 1 1
    CLN3 VPS35 0 0 167 287 1 1
    CLN3 VPS26A 0 0 151 251 1 1
    CLN3 EPM2A 0 0 159 197 1 1
    CLN3 CERS2 0 0 222 222 1 1
    CLN3 KCNIP3 270 0 650 746 1 1
    CLN3 CRX 0 0 167 167 1 1
    CLN3 CP 0 0 93 171 1 1
    CLN3 RAB3GAP2 0 0 155 154 1 1
    CLN3 RAB9B 0 0 0 163 1 1
    CLN3 PRPH2 0 0 205 205 1 1
    CLN3 HSPA14 0 0 143 176 1 1
    CLN3 SAMM50 270 0 0 270 1 1
    CLN3 DNM2 0 0 0 169 1 1
    CLN3 SPNS2 0 0 96 226 1 1
    CLN3 ATP2A1 0 0 398 414 1 1
    CLN3 PCDH15 0 0 171 171 1 1
    CLN3 MFSD12 0 0 170 325 1 1
    CLN3 ROCK2 0 0 81 174 1 1
    CLN3 LRRC28 0 0 180 212 1 1
    CLN3 DGCR14 0 0 95 151 1 1
    CLN3 POLG 0 0 204 283 1 1
    CLN3 MAP3K11 0 0 50 171 1 1
    CLN3 GLB1 0 0 261 261 1 1
    CLN3 ATG16L2 0 0 337 384 1 2
    CLN3 LGALS4 0 0 151 150 1 1
    CLN3 FBXO9 0 0 107 162 1 1
    CLN3 BOLA2B 0 0 0 183 1 1
    CLN3 EFHC1 0 0 203 203 1 1
    CLN3 UNC93B1 0 0 49 256 1 1
    CLN3 CCNB2 0 0 52 223 1 1
    CLN3 RALB 0 0 72 162 1 1
    CLN3 BOLL 0 0 0 197 1 1
    CLN3 GABARAPL1 0 0 150 235 1 2
    CLN3 TUBA1B 0 0 113 207 1 1
    CLN3 ENSG00000269590 0 0 0 215 1 1
    CLN3 MYH9 0 0 312 339 1 1
    CLN3 LMX1A 0 0 0 151 1 1
    CLN3 TMEM189 0 0 150 204 1 1
    CLN3 AGA 0 0 536 536 1 1
    CLN3 SLC35A3 0 0 0 182 1 1
    CLN3 RCN2 270 0 0 270 1 1
    CLN3 HSPA8 0 0 193 244 1 2
    CLN3 RAB24 0 0 235 306 1 2
    CLN3 CDHR1 0 0 208 208 1 1
    CLN3 SFTPB 0 0 0 155 1 1
    CLN3 OR10H5 0 0 267 318 1 1
    CLN3 ATG9A 0 0 217 350 1 2
    CLN3 SQSTM1 0 0 233 263 1 2
    CLN3 KEAP1 0 0 55 157 1 2
    CLN3 FAR1 270 0 528 640 1 1
    CLN3 ACR 0 0 284 284 1 1
    CLN3 SLC7A3 0 0 0 203 1 1
    CLN3 ARHGDIA 0 0 0 176 1 1
    CLN3 DPRX 0 0 0 151 1 1
    CLN3 NOBOX 0 0 0 151 1 1
    CLN3 ACTB 0 0 166 184 1 1
    CLN3 CERKL 0 0 231 230 1 1
    CLN3 FOXG1 0 0 154 228 1 1
    CLN3 HIATL1 0 0 166 220 1 1
    CLN3 ABCA4 0 0 321 321 1 1
    CLN3 ALX4 0 0 0 151 1 1
    CLN3 PRRX1 0 0 0 151 1 1
    CLN3 TFEB 0 0 392 438 1 2
    CLN3 HADHA 0 0 63 170 1 1
    CLN3 GGA2 0 0 123 257 1 1
    CLN3 HSP90AA1 0 0 151 182 1 2
    CLN3 YKT6 0 0 123 254 1 1
    CLN3 DAPK1 0 0 95 154 1 2
    CLN3 SNX1 0 0 82 172 1 1
    CLN3 PSAPL1 0 0 0 155 1 1
    CLN3 TPP1 0 0 759 824 1 1
    CLN3 DIDO1 0 0 82 191 1 1
    CLN3 SI 0 0 167 167 1 1
    CLN3 SIGLEC1 0 0 122 168 1 1
    CLN3 CALB1 0 0 148 184 1 1
    CLN3 XYLT1 0 0 73 170 1 1
    CLN3 SLC38A10 0 0 0 248 1 1
    CLN3 MANBA 0 0 96 360 1 1
    CLN3 HSPA1A 0 0 95 152 1 1
    CLN3 SRF 0 0 323 369 1 1
    CLN3 EPN1 0 0 0 165 1 1
    CLN3 PROP1 0 0 0 154 1 1
    CLN3 CAV1 0 0 141 153 1 1
    CLN3 CDC20 0 0 202 256 1 1
    CLN3 HPCAL1 0 0 96 170 1 1
    CLN3 ULK2 0 0 126 213 1 2
    CLN3 SWI5 0 0 502 502 1 1
    CLN3 ENSG00000258130 0 0 0 189 1 1
    CLN3 SNCA 0 0 283 282 1 2
    CLN3 NPC2 0 0 406 406 1 1
    CLN3 PELO 0 0 0 159 1 1
    CLN3 SGSH 0 0 470 561 1 1
    CLN3 CCNA2 0 0 125 157 1 1
    CLN3 HOOK2 0 0 495 495 1 1
    CLN3 ARSI 0 0 0 188 1 1
    CLN3 SCO1 0 0 77 239 1 1
    CLN3 GM2A 0 0 143 166 1 1
    CLN3 COX15 385 0 0 384 1 1
    CLN3 ARSA 0 0 135 206 1 2
    CLN3 SLC7A10 0 0 67 190 1 1
    CLN3 VSNL1 0 0 294 308 1 1
    CLN3 SLC36A2 0 0 0 193 1 1
    CLN3 ENSG00000270024 0 0 60 192 1 1
    CLN3 VTA1 0 0 0 155 1 1
    CLN3 NUPR1L 0 0 0 177 1 1
    CLN3 MCOLN3 0 0 74 216 1 1
    CLN3 ISL2 0 0 0 151 1 1
    CLN3 MCOLN2 0 0 56 201 1 1
    CLN3 EIF3K 0 0 292 358 1 1
    CLN3 RPN2 385 0 0 384 1 1
    CLN3 SOD1 0 0 82 181 1 1
    CLN3 LRAT 0 0 212 212 1 1
    CLN3 ALX1 0 0 0 151 1 1
    CLN3 ENTPD4 0 0 124 248 1 1
    CLN3 EPN2 0 0 0 157 1 1
    CLN3 GOLGA2 0 0 368 368 1 1
    CLN3 GRN 0 0 270 399 1 1
    CLN3 EYS 0 0 219 219 1 1
    CLN3 CTSF 0 0 562 606 1 1
    CLN3 LAMP2 0 0 218 251 1 2
    CLN3 VCP 0 0 170 192 1 2
    CLN3 SLC25A10 385 0 0 384 1 1
    CLN3 ARF1 0 0 181 201 1 1
    CLN3 HSPA1L 0 0 154 207 1 1
    CLN3 PSAP 0 0 242 332 1 1
    CLN3 SIRT2 0 0 103 178 1 2
    CLN3 CCNB1 0 0 57 227 1 1
    CLN3 NPPA 0 0 389 388 1 1
    CLN3 GRIA4 0 0 142 226 1 1
    CLN3 SLC25A6 270 0 0 270 1 1
    CLN3 NPEPPS 142 0 0 189 1 1
    CLN3 AP3B1 0 0 0 188 1 1
    CLN3 HOPX 0 0 0 151 1 1
    CLN3 CHRNA4 0 0 181 181 1 1
    CLN3 PIK3R4 0 0 187 265 1 2
    CLN3 RDH12 0 0 284 348 1 1
    CLN3 DPEP2 0 0 127 158 1 1
    CLN3 KCNB1 0 0 144 156 1 2
    CLN3 FKBP8 270 0 62 285 1 1
    CLN3 RHOXF2B 0 0 0 151 1 1
    CLN3 GABARAPL2 0 0 206 260 1 2
    CLN3 ENSG00000258466 0 0 0 161 1 1
    CLN3 NMNAT1 0 0 247 246 1 1
    CLN3 APTX 0 0 0 196 1 1
    CLN3 SVOPL 0 0 134 323 1 1
    CLN3 GAPDH 0 0 141 210 1 2
    CLN3 SLC25A11 411 0 0 410 1 1
    CLN3 CHM 0 0 122 162 1 1
    CLN3 RPMS17 0 0 113 208 1 1
    CLN3 DDOST 478 0 113 625 1 1
    CLN3 UGT8 0 0 203 252 1 1
    CLN3 UBE2G1 0 0 166 176 1 1
    CLN3 ARF3 270 0 0 288 1 1
    CLN3 BBS1 0 0 310 309 1 1
    CLN3 ISL1 0 0 0 151 1 1
    CLN3 UQCRC2 270 0 47 274 1 1
    CLN3 ELK3 0 0 160 159 1 1
    CLN3 CNBP 0 0 0 168 1 1
    CLN3 CAPN5 0 0 334 401 1 1
    CLN3 RAB5A 0 0 146 169 1 2
    CLN3 DDX18 0 0 0 271 1 1
    CLN3 XPO1 385 0 0 384 1 1
    CLN3 MVB12B 0 0 140 193 1 1
    CLN3 ATP6V1B1 0 0 95 194 1 1
    CLN3 OSTM1 0 0 60 274 1 1
    CLN3 MAP1LC3A 0 0 389 388 1 2
    CLN3 PEX13 0 0 74 166 1 1
    CLN3 CDK2 0 0 142 205 1 1
    CLN3 APP 0 0 155 154 1 1
    CLN3 GANAB 237 0 94 306 1 1
    CLN3 SCN1A 0 0 151 150 1 1
    CLN3 GLA 0 0 210 214 1 1
    CLN3 SUV420H1 0 0 0 179 1 1
    CLN3 MTOR 0 0 181 308 1 2
    CLN3 SYT7 0 0 92 187 1 1
    CLN3 ATP5D 0 0 0 171 1 1
    CLN3 SULT1A2 0 0 268 294 1 1
    CLN3 SORT1 0 0 142 235 1 1
    CLN3 PEX19 0 0 84 160 1 1
    CLN3 LYPLA1 0 0 65 162 1 1
    CLN3 SPNS1 0 0 358 466 1 2
    CLN3 SEC61A1 270 0 57 342 1 1
    CLN3 SULT1A1 0 0 207 288 1 1
    CLN3 NPIPB9 0 0 423 422 1 1
    CLN3 RARS2 263 0 90 300 1 1
    CLN3 AP5B1 0 0 125 156 1 1
    CLN3 SLC25A1 270 0 0 270 1 1
    CLN3 PPP4C 0 0 102 202 1 1
    CLN3 PIK3C3 0 0 193 256 1 2
    CLN3 MFSD6 0 0 146 335 1 1
    CLN3 ESX1 0 0 0 151 1 1
    CLN3 LAMP1 0 0 392 464 1 2
    CLN3 LHX1 0 0 0 190 1 1
    CLN3 CDK4 0 0 96 192 1 1
    CLN3 HTT 0 0 171 171 1 1
    CLN3 TP53 0 0 113 152 1 2
    CLN3 STX5 0 0 183 294 1 1
    CLN3 RHOXF2 0 0 0 151 1 1
    CLN3 TMEM33 270 0 48 275 1 1
    CLN3 TGM2 0 0 74 159 1 1
    CLN3 YIF1A 0 0 310 462 1 1
    CLN3 SHOX 0 0 0 151 1 1
    CLN3 HMBS 0 0 0 155 1 1
    CLN3 TAAR5 0 0 117 309 1 1
    CLN3 HSPBP1 0 0 57 227 1 1
    CLN3 SS18L2 0 0 247 409 1 1
    CLN3 CTSA 0 0 71 246 1 1
    CLN3 ARF5 270 0 0 353 1 1
    CLN3 SLC25A4 270 0 0 270 1 1
    CLN3 SUMF1 0 0 305 387 1 1
    CLN3 LMX1B 0 0 0 151 1 1
    CLN3 SFXN1 270 0 0 270 1 1
    CLN3 ADH1A 0 0 167 167 1 1
    CLN3 C19orf70 270 0 0 270 1 1
    CLN3 CISD2 0 0 157 243 1 2
    CLN3 HGS 0 0 217 282 1 2
    CLN3 RPGR 0 0 290 312 1 1
    CLN3 MAGEB6 299 0 0 299 1 1
    CLN3 FAM104B 0 0 204 204 1 1
    CLN3 RAX2 0 0 113 215 1 1
    CLN3 HOOK3 0 0 608 608 1 1
    CLN3 SLC7A4 0 0 0 203 1 1
    CLN3 HSPA12B 0 0 187 218 1 1
    CLN3 GNAT1 0 0 101 181 1 1
    CLN3 RBM3 0 0 0 153 1 1
    CLN3 ARSB 0 0 157 286 1 2
    CLN3 CLCN5 0 0 134 476 1 1
    CLN3 CPVL 0 0 0 171 1 1
    CLN3 SNX12 0 0 44 154 1 1
    CLN3 RAB9A 0 0 0 163 1 2
    CLN3 DEGS2 0 0 258 335 1 1
    CLN3 RPN1 270 0 0 270 1 1
    CLN3 IMPDH2 0 0 0 188 1 1
    CLN3 SPTLC1 0 0 210 233 1 1
    CLN3 PRPF31 0 0 218 218 1 1
    CLN3 SFT2D2 0 0 60 159 1 1
    CLN3 MCOLN1 0 0 340 641 1 1
    CLN3 ABCC2 0 0 134 156 1 1
    CLN3 NPHP4 0 0 194 194 1 1
    CLN3 SCARB2 0 0 260 310 1 1
    CLN3 CIB3 0 0 155 172 1 1
    CLN3 CDC14A 0 0 281 298 1 1
    CLN3 WDR12 0 0 613 613 1 1
    CLN3 GSC 0 0 0 151 1 1
    CLN3 C9orf114 0 0 124 313 1 1
    CLN3 TBC1D24 0 0 181 181 1 1
    CLN3 MYC 0 0 469 469 1 2
    CLN3 IRGM 0 0 231 244 1 2
    CLN3 SVOP 0 0 161 312 1 1
    CLN3 RPL35A 0 0 74 278 1 1
    CLN3 LGMN 0 0 95 152 1 1
    CLN3 LMO3 0 0 0 151 1 1
    CLN3 PGA5 0 0 73 158 1 1
    CLN3 CERS1 0 0 213 213 1 1
    CLN3 GNAT2 0 0 75 157 1 1
    CLN3 NAPSA 0 0 0 170 1 1
    CLN3 SIGLEC11 0 0 74 233 1 1
    CLN3 SLC7A1 0 0 0 203 1 1
    CLN3 CDS2 270 0 0 270 1 1
    CLN3 CIB2 0 0 170 187 1 1
    CLN3 NPC1 0 0 402 476 1 2
    CLN3 MYH10 0 0 66 227 1 1
    CLN3 NUPR1 0 0 134 275 1 1
    CLN3 SFTPA2 0 0 157 156 1 1
    CLN3 CLCN4 0 0 0 207 1 1
    CLN3 SEBOX 0 0 0 151 1 1
    CLN3 SYNGR2 0 0 216 240 1 1
    CLN3 CTSE 0 0 0 170 1 1
    CLN3 CAND1 151 0 0 150 1 1
    CLN3 SSR4 270 0 0 270 1 1
    CLN3 ODC1 0 0 0 155 1 1
    CLN3 BOLA2 0 0 0 183 1 1
    CLN3 PEX1 0 0 0 156 1 1
    CLN3 CYB5R2 0 0 0 155 1 1
    CLN3 B3GALT4 0 0 134 291 1 1
    CLN3 SLC30A10 0 0 0 187 1 1
    CLN3 BBS2 0 0 171 171 1 1
    CLN3 ICK 0 0 0 234 1 1
    CLN3 GALC 0 0 162 161 1 1
    CLN3 ATG10 0 0 202 220 1 2
    CLN3 SLC35E2 0 0 165 165 1 1
    CLN3 PLEKHN1 0 0 171 171 1 1
    CLN3 MAP1LC3B 0 0 181 196 1 2
    CLN3 TMEM79 0 0 107 198 1 1
    CLN3 LRP10 0 0 294 428 1 1
    CLN3 ALPK3 0 0 108 182 1 1
    CLN3 UBAP2L 0 0 223 223 1 1
    CLN3 NR2E3 0 0 193 291 1 1
    CLN3 ATP5G1 0 0 574 574 1 1
    CLN3 MFSD4 0 0 55 203 1 1
    CLN3 RPS18 0 0 0 154 1 1
    CLN3 ANO8 0 0 0 295 1 1
    CLN3 GNPTG 0 0 218 218 1 1
    CLN3 ULK1 0 0 98 154 1 2
    CLN3 C4orf27 0 0 0 556 1 1
    CLN3 SLC7A14 0 0 0 203 1 1
    CLN3 MFSD8 0 0 755 865 1 1
    CLN3 CARKD 0 0 0 155 1 1
    CLN3 SNX5 0 0 107 191 1 1
    CLN3 DPM1 270 0 0 270 1 1
    CLN3 SFXN3 270 0 0 270 1 1
    CLN3 SMCR8 0 0 107 157 1 2
    CLN3 CTSB 0 0 233 252 1 2
    CLN3 BBS5 0 0 157 156 1 1
    CLN3 ECI1 0 0 86 185 1 1
    CLN3 BACE1 0 0 96 179 1 1
    CLN3 AFG3L2 151 0 0 168 1 1
    CLN3 ATAD1 0 0 0 154 1 1
    CLN3 B3GALT2 240 0 0 252 1 1
    CLN3 PPT1 0 0 801 934 1 1
    CLN3 DYNC1H1 0 0 145 160 1 1
    CLN3 CHRNB2 0 0 151 150 1 1
    CLN3 SLC17A2 0 0 0 304 1 1
    CLN3 LAPTM5 0 0 283 314 1 1
    CLN3 ATG5 0 0 161 171 1 2
    CLN3 KCTD19 0 0 0 212 1 1
    CLN3 SYP 0 0 438 438 1 1
    CLN3 SNX6 0 0 90 159 1 1
    CLN3 GBE1 0 0 96 191 1 1
    CLN3 RHOXF1 0 0 0 151 1 1
    CLN3 HEMGN 0 0 113 174 1 1
    CLN3 UBE2Q1 0 0 208 208 1 1
    CLN3 WDR90 0 0 0 169 1 1
    CLN3 KIAA0368 385 0 62 398 1 1
    CLN3 FUS 0 0 95 151 1 1
    CLN3 GABARAP 0 0 113 162 1 2
    CLN3 TTC27 0 0 155 228 1 1
    CLN3 VPS26B 0 0 74 237 1 1
    CLN3 KDELC2 0 0 136 199 1 1
    CLN3 EIF3C 0 0 189 276 1 1
    CLN3 AGPS 0 0 177 350 1 1
    CLN3 WIPI1 0 0 120 175 1 2
    CLN3 CERK 0 0 142 165 1 1
    CLN3 NAGPA 0 0 309 351 1 1
    CLN3 RPS20 0 0 60 205 1 1
    CLN3 PRKAA2 0 0 125 158 1 2
    CLN3 AMBRA1 0 0 194 273 1 2
    CLN3 GBA2 0 0 60 171 1 1
    CLN3 CLN6 0 0 870 922 1 1
    CLN3 MAK 0 0 89 282 1 1
    CLN3 AIPL1 0 0 270 270 1 1
    CLN3 DNAJC11 0 0 46 176 1 1
    CLN3 CCDC115 0 0 170 359 1 1
    CLN3 SLC36A4 0 0 0 193 1 1
    CLN3 MAPK10 0 0 46 161 1 2
    CLN3 GUCY2D 0 0 294 294 1 1
    CLN3 CTSD 0 0 615 735 1 2
    CLN3 M6PR 0 0 370 370 1 1
    CLN3 GAD2 0 0 414 414 1 1
    CLN3 VTI1B 0 0 143 189 1 2
    CLN3 CLCN3 0 0 120 272 1 1
    CLN3 ATP5L 270 0 0 270 1 1
    CLN3 ARSJ 0 0 0 188 1 1
    CLN3 CA4 0 0 193 208 1 1
    CLN3 PNKP 0 0 113 363 1 1
    CLN3 ATG7 62 0 675 682 1 2
    CLN3 DBH 270 0 0 270 1 1
    CLN3 ATP6V0A1 0 0 108 174 1 1
    CLN3 ZNF821 0 0 409 421 1 1
    CLN3 STRADB 0 0 112 152 1 1
    CLN3 CNDP1 0 0 81 247 1 1
    CLN3 COL9A2 0 0 438 438 1 1
    CLN3 IQCB1 0 0 340 340 1 1
    CLN3 TMEM106B 0 0 228 241 1 1
    CLN3 DNAJA2 0 0 52 154 1 1
    CLN3 YIF1B 0 0 0 252 1 1
    CLN3 NDRG3 0 0 167 219 1 1
    CLN3 SMPD1 0 0 294 415 1 1
    CLN3 ATG16L1 0 0 119 174 1 2
    CLN3 SLC35A4 0 0 0 201 1 1
    CLN3 ENSG00000250644 0 0 0 170 1 1
    CLN3 ARFGAP1 0 0 96 220 1 1
    CLN3 CUL3 0 0 91 181 1 1
    CLN3 PDE6C 0 0 155 154 1 1
    CLN3 ATP1A2 0 0 139 162 1 1
    CLN3 GUSB 0 0 184 262 1 1
    CLN3 STAMBPL1 0 0 75 159 1 1
    CLN3 CNOT3 0 0 0 152 1 1
    CLN3 KCNQ2 0 0 155 154 1 1
    CLN3 ALX3 0 0 0 151 1 1
    CLN3 CASP4 0 0 155 154 1 2
    CLN3 CDC34 0 0 252 252 1 1
    CLN3 MOK 0 0 0 198 1 1
    CLN3 MFSD1 0 0 184 229 1 1
    CLN3 LHX6 0 0 0 151 1 1
    CLN3 ELP4 0 0 108 203 1 1
    CLN3 CSTB 0 0 321 367 1 1
    CLN3 DIRAS3 0 0 60 151 1 2
    CLN3 HSPA4L 0 0 167 188 1 1
    CLN3 RPL31 0 0 74 234 1 1
    CLN3 MRPL51 0 0 156 308 1 1
    CLN3 CTSS 0 0 173 229 1 1
    CLN3 ASAH1 0 0 241 246 1 1
    CLN3 ATG12 0 0 246 346 1 2
    CLN3 MFSD11 0 0 181 430 1 1
    CLN3 ATP6V1B2 0 0 82 182 1 1
    CLN3 RPS10-NUDT3 0 0 317 364 1 1
    CLN3 GMPPB 0 0 123 166 1 1
    CLN3 ATG4D 0 0 161 213 1 2
    CLN3 DMBX1 0 0 0 151 1 1
    CLN3 TULP1 0 0 310 309 1 1
    CLN3 HSPA1B 0 0 108 164 1 1
    CLN3 BIN2 0 0 123 187 1 1
    CLN3 ORMDL1 0 0 139 157 1 1
    CLN3 ATP6V0A4 0 0 135 199 1 1
    CLN3 DGCR2 0 0 112 167 1 1
    CLN3 UNC93A 0 0 161 307 1 1
    CLN3 IL18R1 0 0 61 229 1 1
    CLN3 STRA6 270 0 0 270 1 1
    CLN3 CLCN6 0 0 424 555 1 1
    CLN3 ATP1A1 270 0 123 350 1 1
    CLN3 TMPO 151 0 0 150 1 1
    CLN3 VAC14 0 0 113 155 1 1
    CLN3 CERS6 0 0 204 209 1 1
    CLN3 TMEM40 0 0 142 228 1 1
    CLN3 MET 0 0 138 180 1 1
    CLN3 ERLIN2 270 0 0 270 1 1
    CLN3 PHB 210 0 0 240 1 1
    CLN3 BECN1 0 0 193 198 1 2
    CLN3 EEF1G 0 0 0 182 1 1
    CLN3 SLC36A3 0 0 0 154 1 1
    CLN3 PRDM8 0 0 0 391 1 1
    CLN3 FBXL19 0 0 0 181 1 1
    CLN3 CYB5R4 0 0 0 155 1 1
    CLN3 WEE1 0 0 66 179 1 1
    CLN3 KIAA1919 0 0 108 311 1 1
    CLN3 NRL 0 0 142 195 1 1
    CLN3 POMK 0 0 202 216 1 1
    CLN3 SNX4 0 0 232 277 1 1
    CLN3 ARMC6 270 0 0 270 1 1
    CLN3 SNRNP200 0 0 141 184 1 1
    CLN3 SCAMP3 270 0 0 308 1 1
    CLN3 SIGLEC15 0 0 0 196 1 1
    CLN3 SH2B1 0 0 219 219 1 1
    CLN3 FOXO1 0 0 73 155 1 2
    CLN3 AP3S2 0 0 134 191 1 1
    CLN3 SLC35B2 270 0 0 299 1 1
    CLN3 DNM1 0 0 81 192 1 1
    CLN3 PDYN 0 0 398 398 1 1
    CLN3 ROM1 0 0 203 203 1 1
    CLN3 TOP2B 0 0 108 166 1 1
    CLN3 TFE3 0 0 124 166 1 1
    CLN3 CNNM4 0 0 249 312 1 1
    CLN3 SNX2 0 0 155 205 1 1
    CLN3 KDM2B 0 0 0 180 1 1
    CLN3 TADA3 0 0 202 282 1 1
    CLN3 PITRM1 0 0 135 194 1 1
    CLN3 LMO1 0 0 0 151 1 1
    CLN3 CCDC78 0 0 166 180 1 1
    CLN3 LMO2 0 0 0 151 1 1
    CLN3 SV2A 0 0 433 438 1 1
    CLN3 CNDP2 0 0 0 174 1 1
    CLN3 MAN2B1 0 0 123 317 1 1
    CLN3 GSC2 0 0 0 151 1 1
    CLN3 ANO10 0 0 0 295 1 1
    CLN3 ALG14 0 0 125 248 1 1
    CLN3 PNPLA7 0 0 134 226 1 1
    CLN3 MAG 0 0 61 154 1 1
    CLN3 CLGN 0 0 43 191 1 1
    CLN3 HIBCH 0 0 103 200 1 1
    CLN3 EMD 270 0 45 304 1 1
    CLN3 WWOX 0 0 109 164 1 1
    CLN3 ENSG00000258150 0 0 0 189 1 1
    CLN3 RALY 0 0 0 168 1 1
    CLN3 SLC7A2 0 0 0 203 1 1
    CLN3 PHGDH 270 0 62 285 1 1
    CLN3 PIKFYVE 0 0 57 170 1 1
    CLN3 USH2A 0 0 293 303 1 1
    CLN3 TAAR2 0 0 0 189 1 1
    CLN3 CRB1 0 0 390 394 1 1
    CLN3 IPO8 0 0 88 165 1 1
    CLN3 HSP90AB1 0 0 150 181 1 2
    CLN3 EFCAB13 0 0 161 390 1 1
    CLN3 ATP6V1A 0 0 233 336 1 1
    CLN3 PTPLAD1 270 0 0 276 1 1
    CLN3 IMMP1L 0 0 151 150 1 1
    CLN3 IGF2R 0 0 225 224 1 1
    CLN3 CCDC101 0 0 233 441 1 1
    CLN3 MGAM 0 0 161 161 1 1
    CLN3 ZNF408 0 0 137 154 1 1
    CLN3 AIFM1 0 0 113 177 1 1
    CLN3 APOL4 0 0 161 218 1 1
    CLN3 DHODH 0 0 0 158 1 1
    CLN3 LARP4B 0 0 143 329 1 1
    CLN3 DRGX 0 0 0 151 1 1
    CLN3 LHX2 0 0 0 151 1 1
    CLN3 WEE2 0 0 0 157 1 1
    CLN3 CPT1A 385 0 0 384 1 1
    CLN3 AKT1 0 0 150 179 1 2
    CLN3 RBMXL1 0 0 180 179 1 1
    CLN3 HSPH1 0 0 157 178 1 1
    CLN3 MAP3K15 0 0 113 248 1 1
    CLN3 SGK3 0 0 54 187 1 1
    CLN3 ALS2 0 0 166 193 1 1
    CLN3 CIRBP 0 0 61 186 1 1
    CLN3 ACE2 0 0 207 207 1 1
    CLN3 LRP4 0 0 250 250 1 1
    CLN3 AHI1 0 0 225 254 1 1
    CLN3 SLC36A1 0 0 0 193 1 1
    CLN3 TMEM74 0 0 370 459 1 2
    CLN3 NADK 0 0 96 182 1 1
    CLN3 ARF4 270 0 0 315 1 1
    CLN3 SLC25A3 270 0 64 301 1 1
    CLN3 HSD17B12 423 0 0 480 1 1
    CLN3 CYP4V2 0 0 170 213 1 1
    CLN3 CACNA1A 0 0 211 211 1 1
    CLN3 CLN8 0 0 856 895 1 1
    CLN3 RGS19 0 0 134 173 1 2
    CLN3 YTHDC2 0 0 0 157 1 1
    CLN3 SLC17A7 0 0 0 179 1 1
    CLN3 HIAT1 0 0 147 203 1 1
    CLN3 CDHR3 151 0 0 150 1 1
    CLN3 RAB11A 0 0 443 456 1 1
    CLN3 ATF6B 0 0 86 161 1 1
    CLN3 SPOCK2 0 0 75 248 1 1
    CLN3 RAB7B 0 0 520 581 1 1
    CLN3 RAX 0 0 0 151 1 1
    CLN3 SLC25A22 423 0 112 465 1 1
    CLN3 ECI2 0 0 88 150 1 1
    CLN3 DDX20 142 0 0 171 1 1
    CLN3 RABIF 0 0 177 177 1 1
    CLN3 GLUL 0 0 171 171 1 1
    CLN3 CLCN7 0 0 201 461 1 1
    CLN3 SLC25A13 270 0 0 270 1 1
    CLN3 ISX 0 0 0 151 1 1
    CLN3 OTP 0 0 0 151 1 1
    CLN3 NPIPB8 0 0 298 298 1 1
    CLN3 DUXA 0 0 0 151 1 1
    CLN3 DUSP11 0 0 126 297 1 1
    CLN3 DNAJC5 0 0 710 760 1 1
    CLN3 RABEP2 0 0 320 440 1 1
    CLN3 POLB 0 0 60 172 1 1
    CLN3 AP3M1 0 0 535 535 1 1
    CLN3 CDC42 0 0 122 158 1 1
    CLN3 MFSD6L 0 0 213 482 1 1
    CLN3 HSPA12A 0 0 181 212 1 1
    CLN3 ATG4C 0 0 135 174 1 2
    CLN3 SORL1 0 0 74 174 1 1
    CLN3 PKMYT1 0 0 0 176 1 1
    CLN3 HP 0 0 329 329 1 1
    CLN3 WBSCR22 0 0 107 246 1 1
    CLN3 FBXW11 0 0 113 162 1 1
    CLN3 NAGLU 0 0 370 415 1 1
    CLN3 HEXA 0 0 285 295 1 1
    CLN3 RABGEF1 0 0 61 284 1 1
    CLN3 CDKN3 0 0 134 155 1 1
    CLN3 SH3RF3 0 0 60 155 1 1
    CLN3 RPE65 0 0 232 231 1 1
    CLN3 SLC25A5 270 0 75 295 1 1
    CLN3 ATG3 0 0 181 270 1 2
    CLN3 JMJD7-PLA2G4B 0 0 0 186 1 1
    CLN3 CDK1 0 0 212 270 1 1
    CLN3 PRKDC 284 0 0 330 1 2
    CLN3 IDUA 0 0 159 171 1 1
    CLN3 LPGAT1 270 0 96 350 1 1
    CLN3 PGC 0 0 0 151 1 1
    CLN3 CNGB3 0 0 189 189 1 1
    CLN3 PRRX2 0 0 0 151 1 1
    CLN3 DMTF1 0 0 86 335 1 1
    CLN3 LMO4 0 0 0 151 1 1
    CLN3 SPNS3 0 0 182 300 1 1
    CLN3 UXT 0 0 146 199 1 1
    CLN3 SLC35A2 0 0 0 182 1 1
    CLN3 SIGLEC10 0 0 0 155 1 1
    CLN3 MARC1 0 0 143 196 1 1
    CLN3 UNCX 0 0 0 151 1 1
    CLN3 PPT2 0 0 398 573 1 1
    CLN3 PRKAA1 0 0 183 268 1 2
    CLN3 PRSS53 0 0 141 200 1 1
    CLN3 GPR143 0 0 158 165 1 1
    CLN3 FLI1 0 0 557 557 1 1
    CLN3 LPHN2 270 0 0 270 1 1
    CLN3 CCND1 0 0 87 225 1 1
    CLN3 SV2B 0 0 74 157 1 1
    CLN3 CLN5 270 0 944 969 1 1
    CLN3 ATP2A2 270 0 48 294 1 1
    CLN3 GBA 0 0 315 437 1 1
    CLN3 ZCCHC7 0 0 0 190 1 1
    CLN3 APOBR 0 0 469 549 1 1
    CLN3 BAK1 0 0 233 280 1 2
    CLN3 MAP2K2 0 0 0 166 1 1
    CLN3 NAA20 0 0 0 189 1 1
    CLN3 UXS1 0 0 54 157 1 1
    CLN3 RHEB 0 0 72 498 1 2
    CLN3 SLC17A5 0 0 161 606 1 1
    CLN3 FADS2 270 0 0 270 1 1
    CLN3 MCM7 0 0 156 155 1 1
    CLN3 FBXL4 0 0 97 150 1 1
    CLN3 ABR 0 0 452 452 1 1
    CLN3 ALMS1 0 0 167 236 1 1
    CLN3 STX19 0 0 203 249 1 1
    CLN3 FANCI 151 0 0 150 1 1
    CLN3 CAT 0 0 0 219 1 1
    CLN3 MFSD10 0 0 188 317 1 1
    CLN3 HSPA13 0 0 162 194 1 1
    CLN3 NUP205 385 0 0 384 1 1
    CLN3 LAPTM4A 0 0 143 196 1 1
    CLN3 SRR 0 0 97 187 1 1
    CLN3 EPB41L2 0 0 112 152 1 1
    CLN3 HSPA2 0 0 138 192 1 1
    CLN3 NHLRC1 0 0 234 234 1 1
    CLN3 SNAP25 0 0 141 159 1 1
    CLN3 MARC2 0 0 138 226 1 1
    CLN3 OR10H1 0 0 240 293 1 1
    CLN3 LHX9 0 0 0 151 1 1
    CLN3 ALDH7A1 0 0 134 249 1 1
    CLN3 ATXN2L 0 0 321 321 1 1
    CLN3 PNPLA6 0 0 143 217 1 1
    CLN3 ATP13A2 0 0 600 640 1 2
    CLN3 IFT140 0 0 193 193 1 1
    CLN3 RPLP0 0 0 122 198 1 1
    CLN3 RBM8A 0 0 0 264 1 1
    CLN3 ZFAND5 0 0 108 163 1 1
    CLN3 CKAP4 210 0 0 210 1 1
    CLN3 NAGA 0 0 112 173 1 1
    CLN3 ATG4B 0 0 126 190 1 2
    CLN3 ARX 0 0 0 151 1 1
    CLN3 TFRC 270 0 125 342 1 1
    CLN3 CYB5R3 0 0 0 155 1 1
    CLN3 CCND2 0 0 61 265 1 1
    CLN3 SV2C 0 0 90 233 1 1
    CLN3 ABCC6 0 0 123 165 1 1
    CLN3 SLC17A8 0 0 0 179 1 1
    CLN3 RAB7A 0 0 644 700 1 2
    CLN3 DRAM1 0 0 113 185 1 2
    CLN3 CEP290 0 0 369 369 1 1
    CLN3 SEC61A2 129 0 0 201 1 1
    CLN3 CYB5RL 0 0 0 176 1 1
    CLN3 CCT2 0 0 66 269 1 1
    CLN3 CCND3 0 0 74 314 1 1
    CLN3 MTHFSD 0 0 161 161 1 1
    CLN3 WDR45 0 0 162 161 1 2
    CLN3 SNF8 0 0 96 189 1 1
    CLN3 SHOX2 0 0 0 151 1 1
    CLN3 UVRAG 0 0 137 196 1 2
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0048306 Molecular Function calcium-dependent protein binding enables IEA
    GO:0051861 Molecular Function glycolipid binding enables IDA
    GO:0017089 Molecular Function glycolipid transfer activity enables TAS
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0120146 Molecular Function sulfatide binding enables IDA
    GO:0090160 Biological Process Golgi to lysosome transport involved_in IMP
    GO:1903826 Biological Process L-arginine transmembrane transport involved_in IDA
    GO:0030036 Biological Process actin cytoskeleton organization involved_in IEA
    GO:0001508 Biological Process action potential involved_in ISS
    GO:0042987 Biological Process amyloid precursor protein catabolic process involved_in IDA
    GO:0008306 Biological Process associative learning involved_in ISS
    GO:0097352 Biological Process autophagosome maturation involved_in ISS
    GO:0061909 Biological Process autophagosome-lysosome fusion involved_in ISS
    GO:0043534 Biological Process blood vessel endothelial cell migration involved_in IEA
    GO:0035627 Biological Process ceramide transport involved_in TAS
    GO:0046474 Biological Process glycerophospholipid biosynthetic process involved_in IMP
    GO:0046836 Biological Process glycolipid transport involved_in IMP
    GO:0009992 Biological Process intracellular water homeostasis involved_in ISS
    GO:0035235 Biological Process ionotropic glutamate receptor signaling pathway involved_in ISS
    GO:0007611 Biological Process learning or memory involved_in ISS
    GO:0007042 Biological Process lysosomal lumen acidification involved_in IBA
    GO:0007042 Biological Process lysosomal lumen acidification involved_in IMP
    GO:0035752 Biological Process lysosomal lumen pH elevation involved_in IDA
    GO:1905146 Biological Process lysosomal protein catabolic process involved_in ISS
    GO:0007040 Biological Process lysosome organization involved_in IBA
    GO:0007040 Biological Process lysosome organization involved_in ISS
    GO:0061024 Biological Process membrane organization involved_in ISS
    GO:0043066 Biological Process negative regulation of apoptotic process involved_in IMP
    GO:0043066 Biological Process negative regulation of apoptotic process involved_in ISS
    GO:0043524 Biological Process negative regulation of neuron apoptotic process involved_in ISS
    GO:0045861 Biological Process negative regulation of proteolysis involved_in ISS
    GO:0050885 Biological Process neuromuscular process controlling balance involved_in ISS
    GO:0090384 Biological Process phagosome-lysosome docking involved_in ISS
    GO:0090385 Biological Process phagosome-lysosome fusion involved_in ISS
    GO:0044857 Biological Process plasma membrane raft organization involved_in ISS
    GO:0042998 Biological Process positive regulation of Golgi to plasma membrane protein transport involved_in ISS
    GO:2001288 Biological Process positive regulation of caveolin-mediated endocytosis involved_in ISS
    GO:0048549 Biological Process positive regulation of pinocytosis involved_in ISS
    GO:0072659 Biological Process protein localization to plasma membrane involved_in IEA
    GO:0016485 Biological Process protein processing involved_in ISS
    GO:0006898 Biological Process receptor-mediated endocytosis involved_in IMP
    GO:1900079 Biological Process regulation of arginine biosynthetic process involved_in ISS
    GO:1901096 Biological Process regulation of autophagosome maturation involved_in ISS
    GO:0016243 Biological Process regulation of autophagosome size involved_in IEA
    GO:0106049 Biological Process regulation of cellular response to osmotic stress involved_in IMP
    GO:0051493 Biological Process regulation of cytoskeleton organization involved_in IMP
    GO:0051480 Biological Process regulation of cytosolic calcium ion concentration involved_in ISS
    GO:0010762 Biological Process regulation of fibroblast migration involved_in IMP
    GO:0051489 Biological Process regulation of filopodium assembly involved_in IEA
    GO:1905244 Biological Process regulation of modification of synaptic structure involved_in ISS
    GO:1905162 Biological Process regulation of phagosome maturation involved_in ISS
    GO:1903076 Biological Process regulation of protein localization to plasma membrane involved_in ISS
    GO:0070613 Biological Process regulation of protein processing involved_in IMP
    GO:0048172 Biological Process regulation of short-term neuronal synaptic plasticity involved_in ISS
    GO:0032228 Biological Process regulation of synaptic transmission, GABAergic involved_in ISS
    GO:0051966 Biological Process regulation of synaptic transmission, glutamatergic involved_in ISS
    GO:0036359 Biological Process renal potassium excretion involved_in ISS
    GO:0047496 Biological Process vesicle transport along microtubule involved_in IMP
    GO:0005794 Cellular Component Golgi apparatus located_in IDA
    GO:0005794 Cellular Component Golgi apparatus located_in IMP
    GO:0000139 Cellular Component Golgi membrane located_in IDA
    GO:0000139 Cellular Component Golgi membrane located_in TAS
    GO:0005795 Cellular Component Golgi stack located_in IDA
    GO:0044754 Cellular Component autolysosome located_in ISS
    GO:0005776 Cellular Component autophagosome located_in ISS
    GO:0005901 Cellular Component caveola located_in IDA
    GO:0005901 Cellular Component caveola located_in IMP
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in IEA
    GO:0005769 Cellular Component early endosome located_in IDA
    GO:0031901 Cellular Component early endosome membrane located_in IMP
    GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IDA
    GO:0005770 Cellular Component late endosome located_in IDA
    GO:0005770 Cellular Component late endosome located_in IMP
    GO:0005770 Cellular Component late endosome located_in ISS
    GO:0031902 Cellular Component late endosome membrane located_in IEA
    GO:0005765 Cellular Component lysosomal membrane located_in HDA
    GO:0005765 Cellular Component lysosomal membrane located_in IDA
    GO:0005765 Cellular Component lysosomal membrane located_in IMP
    GO:0005764 Cellular Component lysosome is_active_in IBA
    GO:0005764 Cellular Component lysosome located_in IDA
    GO:0005764 Cellular Component lysosome located_in IMP
    GO:0016020 Cellular Component membrane located_in IDA
    GO:0045121 Cellular Component membrane raft located_in IDA
    GO:0045121 Cellular Component membrane raft located_in IMP
    GO:0043005 Cellular Component neuron projection located_in IDA
    GO:0005634 Cellular Component nucleus located_in IDA
    GO:0005886 Cellular Component plasma membrane located_in IDA
    GO:0005886 Cellular Component plasma membrane located_in IMP
    GO:0055037 Cellular Component recycling endosome located_in IDA
    GO:0008021 Cellular Component synaptic vesicle located_in IDA
    GO:0005802 Cellular Component trans-Golgi network located_in IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001286109 2 mRNA transcript variant 5 NC_000016 Reference
    NM_001286104 2 mRNA transcript variant 3 NC_000016 Reference
    NM_001286105 2 mRNA transcript variant 4 NC_000016 Reference
    NM_001286110 2 mRNA transcript variant 6 NC_000016 Reference
    NM_000086 2 mRNA transcript variant 2 NC_000016 Reference
    NM_001042432 2 mRNA transcript variant 1 NC_000016 Reference