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ADM

adrenomedullin
General Information
Name adrenomedullin
Alias
  • pro-adrenomedullin
  • preproadrenomedullin
  • proadrenomedullin N-20 terminal peptide
Gene_family Neuropeptides
organism Homo sapiens
entrez_id 133
location 11p15.4
transcript_count 1
exon_count 4
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
    Stringdb ADM; AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels; Endogenous ligands
    nextProt AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
ADM BioGRID DCLK3 GeneID BioGRID Reconstituted Complex
ADM BioGRID NAP1L5 GeneID BioGRID Affinity Capture-MS
ADM BioGRID DDX39A GeneID BioGRID Affinity Capture-RNA
ADM BioGRID DPYS GeneID BioGRID Affinity Capture-MS
ADM Protein CALCRL GeneID HPRD
ADM Protein EDN1 GeneID HPRD
ADM Protein CFH GeneID HPRD
ADM Protein MME GeneID HPRD
ADM Protein ADM GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
ADM RLN3 0 500 83 532 1 1
ADM CXCL12 0 0 343 357 1 2
ADM CCL18 0 0 180 186 1 1
ADM TIMP1 0 0 293 335 1 1
ADM PYY 0 0 241 240 1 1
ADM PI16 0 0 153 152 1 1
ADM TNNI3 0 0 289 288 1 1
ADM PLA2G1B 0 0 154 161 1 1
ADM CITED2 0 0 150 188 1 1
ADM CARTPT 0 0 122 218 1 1
ADM DUSP16 0 0 53 255 1 1
ADM S100A12 0 0 134 161 1 1
ADM RHOA 0 0 148 163 1 2
ADM SST 0 0 365 365 1 1
ADM FABP4 0 0 181 181 1 1
ADM GNRH1 0 0 291 290 1 1
ADM SUSD4 0 0 75 172 1 1
ADM S100B 0 0 263 263 1 1
ADM SPP1 0 0 294 294 1 2
ADM BLK 0 0 0 412 1 1
ADM MRC1 0 0 172 171 1 1
ADM GNB1 800 0 0 800 1 1
ADM ICAM1 0 0 284 304 1 2
ADM HIGD1A 0 0 87 154 1 1
ADM ADORA2A 0 0 233 232 1 1
ADM CSF1 0 0 179 223 1 1
ADM APLNR 0 0 208 208 1 1
ADM RLN2 0 500 108 545 1 1
ADM PPP1R3D 0 0 0 189 1 1
ADM PTPRC 0 0 167 167 1 1
ADM CEBPB 0 0 122 208 1 2
ADM CRP 0 0 594 594 1 2
ADM IL1RL1 0 0 134 154 1 1
ADM FIGF 0 0 282 303 1 1
ADM PTGS2 0 0 290 332 1 2
ADM F3 0 0 207 232 1 1
ADM CASP3 0 0 251 251 1 2
ADM IL33 0 0 157 156 1 2
ADM EGLN1 0 0 262 284 1 1
ADM CXCL1 0 0 171 241 1 2
ADM ALDOB 0 0 165 191 1 1
ADM HCRT 0 0 144 176 1 1
ADM REL 0 0 90 442 1 2
ADM LBP 0 0 113 411 1 1
ADM GNG2 800 0 0 800 1 1
ADM PLA2G7 0 0 174 173 1 1
ADM MMP14 0 0 142 236 1 1
ADM FOSL1 0 0 67 161 1 1
ADM BNIP3 0 0 268 313 1 2
ADM VEGFC 0 0 329 390 1 1
ADM CYBB 0 0 158 157 1 2
ADM CRYM 0 0 83 242 1 1
ADM PRLH 0 0 124 162 1 1
ADM THY1 0 0 136 155 1 1
ADM ANGPT1 0 0 391 403 1 1
ADM MAPK3 0 0 240 245 1 2
ADM MMP9 0 0 372 375 1 2
ADM B2M 0 0 182 181 1 1
ADM ACE 0 0 517 545 1 1
ADM GLP1R 0 0 195 209 1 1
ADM ANG 0 0 261 283 1 2
ADM TNNT1 0 0 167 167 1 1
ADM FGF1 0 0 197 197 1 1
ADM CTTN 0 0 72 199 1 1
ADM ENSG00000258555 0 0 170 169 1 1
ADM GPER1 0 0 128 182 1 2
ADM REN 0 0 698 698 1 1
ADM SPON2 0 0 81 179 1 1
ADM ACTB 0 0 267 271 1 2
ADM CLDN5 0 0 139 160 1 1
ADM SELP 0 0 181 181 1 1
ADM INS 0 0 468 468 1 2
ADM CAV1 0 0 151 203 1 2
ADM ANGPT4 0 0 218 218 1 1
ADM FLT4 0 0 234 245 1 1
ADM FGF23 0 0 159 158 1 1
ADM DUSP1 0 0 193 306 1 1
ADM COL18A1 0 0 155 180 1 1
ADM MET 0 0 143 168 1 2
ADM THBS1 0 0 272 316 1 1
ADM NTN4 0 0 134 173 1 1
ADM NR6A1 0 0 43 188 1 1
ADM SLC16A3 0 0 154 204 1 1
ADM PLAT 0 0 145 166 1 1
ADM NOS1 0 0 249 248 1 1
ADM SFRP2 0 0 159 249 1 1
ADM IL2 0 0 159 158 1 1
ADM PGF 0 0 391 390 1 1
ADM JUN 0 0 249 248 1 2
ADM FABP3 0 0 209 216 1 1
ADM GP1BA 0 0 0 189 1 1
ADM UTS2 0 0 323 373 1 1
ADM ADCYAP1R1 0 0 161 175 1 1
ADM SERPINB2 0 0 95 197 1 1
ADM NPPB 0 0 565 565 1 1
ADM DLL4 0 0 234 289 1 1
ADM TACR1 0 0 157 156 1 1
ADM NR2F2 0 0 150 168 1 1
ADM AMY2B 0 0 391 390 1 1
ADM SCD5 0 0 52 227 1 1
ADM WIPF2 0 0 82 163 1 1
ADM ARNT 0 0 341 356 1 2
ADM ANGPTL4 0 0 290 320 1 1
ADM SPINK13 0 0 103 165 1 1
ADM GPR182 0 0 825 825 1 1
ADM PENK 0 0 210 350 1 1
ADM FOS 0 0 342 366 1 2
ADM ANK1 0 0 134 157 1 1
ADM GHRH 0 500 184 593 1 1
ADM JAG1 0 0 108 155 1 1
ADM SOCS3 0 0 113 236 1 1
ADM ANGPT2 0 0 390 390 1 1
ADM TSHB 0 500 57 517 1 1
ADM PCSK4 0 0 81 177 1 1
ADM EPAS1 0 0 203 310 1 2
ADM MMP2 0 0 324 357 1 2
ADM PTH 0 500 283 642 1 1
ADM SOD2 0 0 96 151 1 2
ADM IGFBP3 0 0 162 203 1 2
ADM RAMP1 417 800 922 990 1 1
ADM VIPR1 0 0 336 450 1 1
ADM PDYN 0 0 134 210 1 1
ADM PTMS 0 0 82 175 1 1
ADM DACH2 0 0 54 153 1 1
ADM CD8A 0 0 164 163 1 1
ADM CALCA 0 800 857 974 1 1
ADM CYP11B2 0 0 351 351 1 1
ADM TM4SF1 0 0 66 636 1 1
ADM ENO2 0 0 240 256 1 1
ADM PTGIS 0 0 183 200 1 1
ADM CASR 0 0 166 209 1 2
ADM FN1 0 0 322 344 1 2
ADM BHLHE40 0 0 144 163 1 1
ADM ADIPOQ 0 0 391 390 1 2
ADM PTH2 0 500 246 606 1 1
ADM GAL 0 0 320 334 1 1
ADM UTS2R 0 0 143 167 1 1
ADM PDRG1 0 0 60 163 1 1
ADM NPS 0 500 143 553 1 1
ADM ARG1 0 0 181 198 1 2
ADM GCLC 0 0 142 201 1 1
ADM FRZB 0 0 167 181 1 1
ADM RAMP2 878 800 977 999 1 1
ADM CTGF 0 0 310 344 1 1
ADM CORT 0 0 391 390 1 1
ADM TGFBR1 0 0 54 218 1 1
ADM PDGFA 0 0 126 472 1 1
ADM CORIN 0 0 185 202 1 1
ADM WDFY4 0 0 0 244 1 1
ADM CALCRL 928 800 981 999 1 1
ADM VR1 0 0 234 234 1 1
ADM TIMP2 0 0 167 197 1 1
ADM TRAM2 0 0 72 333 1 1
ADM ADAM17 0 0 306 306 1 1
ADM CEBPD 0 0 134 183 1 1
ADM MT-ND1 0 0 0 211 1 1
ADM TIE1 0 0 119 183 1 1
ADM DEFB103B 0 0 171 171 1 1
ADM PPY 0 0 310 309 1 1
ADM GNAS 800 0 0 812 1 1
ADM TEK 0 0 295 302 1 1
ADM IER3 0 0 122 206 1 1
ADM CRH 0 500 293 631 1 1
ADM TATDN2 0 0 113 248 1 1
ADM LIF 0 0 163 195 1 2
ADM CFD 0 0 448 448 1 1
ADM GHRHR 0 0 124 184 1 1
ADM GCGR 0 0 218 231 1 1
ADM CRHR1 0 0 181 181 1 1
ADM ATP6AP2 0 0 295 295 1 1
ADM ELN 0 0 202 202 1 1
ADM PLAUR 0 0 235 309 1 1
ADM RGS2 0 0 157 173 1 1
ADM PLAU 0 0 234 341 1 1
ADM IGFBP1 0 0 141 163 1 1
ADM PRL 0 0 246 245 1 1
ADM EGF 0 0 294 294 1 2
ADM BMP2 0 0 156 177 1 1
ADM OTOR 0 0 81 320 1 1
ADM ETS1 0 0 306 306 1 1
ADM POMC 0 500 468 741 1 1
ADM TRPA1 0 0 137 160 1 1
ADM ITGAM 0 0 165 165 1 1
ADM GADD45B 0 0 116 170 1 1
ADM DUSP12 0 0 154 160 1 1
ADM SCTR 0 0 230 307 1 1
ADM NRP1 0 0 155 155 1 1
ADM COPS5 0 0 0 189 1 1
ADM ESR1 0 0 181 181 1 2
ADM ZC3H12A 0 0 52 156 1 1
ADM LDHA 0 0 218 218 1 2
ADM SCT 0 500 323 647 1 1
ADM OPRL1 0 0 134 193 1 1
ADM AMBP 0 0 442 442 1 1
ADM CASQ2 0 0 576 576 1 1
ADM NFKBIA 0 0 134 171 1 2
ADM KIT 0 0 142 161 1 2
ADM SERPINF1 0 0 118 160 1 1
ADM LEP 0 0 390 390 1 1
ADM NPPC 0 0 561 561 1 1
ADM PTH1R 0 0 134 208 1 1
ADM IL4 0 0 180 179 1 1
ADM UCP1 0 0 151 150 1 2
ADM ADRB3 0 0 112 206 1 1
ADM PGK1 0 0 181 198 1 2
ADM VEGFA 0 0 594 609 1 2
ADM FSD1L 0 0 119 182 1 1
ADM PVALB 0 0 56 150 1 1
ADM SLC2A14 0 0 146 196 1 1
ADM AACS 0 0 43 226 1 1
ADM ITLN1 0 0 207 207 1 1
ADM PTEN 0 0 135 153 1 2
ADM BET1 0 0 49 623 1 1
ADM MME 213 0 468 563 1 1
ADM LEPR 0 0 123 155 1 1
ADM MRGPRF 0 0 120 190 1 1
ADM SENP8 0 0 181 186 1 1
ADM CD68 0 0 150 171 1 2
ADM ALB 0 0 395 394 1 2
ADM CCL2 0 0 390 419 1 2
ADM KNG1 0 0 557 557 1 1
ADM TAC1 0 0 506 506 1 1
ADM FAM57A 0 0 108 164 1 1
ADM TJP1 0 0 186 186 1 1
ADM ACVR2B 0 0 63 164 1 1
ADM SELE 0 0 233 232 1 1
ADM EGLN2 0 0 211 237 1 1
ADM TGFBR2 0 0 81 421 1 1
ADM IL1A 0 0 209 232 1 1
ADM TFPI 0 0 155 154 1 1
ADM ATP8B3 0 0 103 164 1 1
ADM AVP 0 500 685 835 1 1
ADM CCL4 0 0 161 179 1 1
ADM GDF15 0 0 469 488 1 1
ADM IAPP 0 800 760 957 1 2
ADM CCNL1 0 0 96 242 1 1
ADM GFAP 0 0 140 159 1 2
ADM NR3C2 0 0 245 244 1 1
ADM DPP4 0 0 128 166 1 1
ADM EFNB2 0 0 151 151 1 1
ADM IL10 0 0 344 343 1 2
ADM NAMPT 0 0 210 271 1 2
ADM APITD1 0 0 45 150 1 1
ADM IGF2 0 0 194 199 1 1
ADM NDUFS2 0 0 72 193 1 1
ADM NMU 0 0 232 287 1 1
ADM PLG 0 0 321 321 1 1
ADM MLN 0 0 242 241 1 2
ADM THBD 0 0 182 206 1 1
ADM DUSP10 0 0 45 176 1 1
ADM BMP7 0 0 135 153 1 1
ADM SCG2 0 0 207 265 1 1
ADM PDPN 0 0 181 181 1 1
ADM BTBD11 0 0 202 202 1 1
ADM CCL3 0 0 166 165 1 1
ADM DUSP8 0 0 49 155 1 1
ADM ENG 0 0 202 219 1 2
ADM INSL6 0 0 124 178 1 1
ADM PAM 0 0 401 422 1 1
ADM TXNDC11 0 0 73 217 1 1
ADM TRH 0 0 233 232 1 1
ADM TNFRSF11B 0 0 184 202 1 1
ADM NPW 0 0 142 195 1 1
ADM ANXA2 0 0 146 196 1 1
ADM FOXC2 0 0 123 181 1 1
ADM MMRN1 0 0 48 154 1 1
ADM CALCB 0 800 764 950 1 1
ADM ADAMTS1 0 0 122 271 1 1
ADM COL23A1 0 0 70 163 1 1
ADM NOS3 0 0 467 467 1 2
ADM ANKRD37 0 0 181 254 1 1
ADM CSF3 0 0 154 172 1 1
ADM CAMP 0 0 273 273 1 2
ADM EDN3 0 0 386 397 1 1
ADM CCND1 0 0 123 155 1 2
ADM HK2 0 0 137 187 1 2
ADM TM4SF4 0 0 63 161 1 1
ADM NPB 0 0 134 284 1 1
ADM FGF7 0 0 144 182 1 1
ADM SLPI 0 0 195 211 1 1
ADM NEDD8 0 0 89 246 1 2
ADM SLC2A1 0 0 292 331 1 2
ADM SERPINE1 0 0 391 462 1 1
ADM SCG3 0 0 451 451 1 1
ADM PGR 0 0 164 163 1 1
ADM GRP 0 0 325 325 1 2
ADM ADORA3 0 0 180 179 1 1
ADM FCGR1A 0 0 95 159 1 1
ADM AGTR1 0 0 284 284 1 1
ADM DEFB103A 0 0 171 171 1 1
ADM ADRB2 0 0 243 242 1 1
ADM ECM1 0 0 108 211 1 1
ADM EGFR 0 0 215 237 1 2
ADM CGA 0 500 0 499 1 2
ADM LOX 0 0 175 241 1 2
ADM LHB 0 500 0 499 1 1
ADM SAG 0 0 180 194 1 1
ADM LCN2 0 0 368 368 1 1
ADM TP53 0 0 181 181 1 2
ADM EDNRA 0 0 357 357 1 1
ADM MYOZ2 0 0 443 443 1 1
ADM TAC4 0 0 181 181 1 1
ADM PROK2 0 0 113 168 1 1
ADM FSTL1 0 0 193 223 1 1
ADM PTN 0 0 155 161 1 1
ADM TGFA 0 0 323 323 1 1
ADM HGF 0 0 369 383 1 2
ADM NPR2 0 0 166 184 1 1
ADM ENSG00000264813 0 0 517 545 1 1
ADM HBEGF 0 0 218 237 1 1
ADM SLC9A3R1 0 0 124 162 1 1
ADM BMPR2 0 0 112 190 1 1
ADM TXN 0 0 134 152 1 1
ADM STAT3 0 0 218 218 1 2
ADM EDN2 0 0 194 209 1 1
ADM C2orf40 0 0 145 198 1 1
ADM GCLM 0 0 145 213 1 1
ADM PECAM1 0 0 295 295 1 1
ADM CAT 0 0 216 216 1 2
ADM GIP 0 500 161 570 1 1
ADM CHGB 0 0 156 254 1 1
ADM SLC26A5 0 0 0 188 1 1
ADM GHRL 0 0 371 371 1 1
ADM MDK 0 0 193 193 1 1
ADM BPIFC 0 0 0 188 1 1
ADM RBM3 0 0 90 190 1 1
ADM PTX3 0 0 294 356 1 1
ADM DDIT4 0 0 169 204 1 2
ADM ALDH7A1 0 0 181 181 1 1
ADM TMSB4X 0 0 150 188 1 1
ADM TAC3 0 0 151 157 1 1
ADM ACADM 0 0 419 418 1 1
ADM RCAN1 0 0 322 321 1 2
ADM MMP7 0 0 167 167 1 1
ADM PPP1R2 0 0 68 197 1 1
ADM RLN1 0 0 103 159 1 1
ADM SLC16A2 0 0 96 161 1 1
ADM EGLN3 0 0 283 311 1 1
ADM ADORA1 0 0 181 181 1 1
ADM PPP1R3C 0 0 75 210 1 1
ADM GNAQ 0 0 170 169 1 1
ADM INSL3 0 500 54 506 1 1
ADM TBX5 0 0 46 170 1 1
ADM NTS 0 0 296 340 1 1
ADM SEMA4D 0 0 128 151 1 1
ADM PI3 0 0 162 194 1 2
ADM LHX9 0 0 46 151 1 1
ADM TREM1 0 0 253 252 1 1
ADM TNF 0 0 465 476 1 2
ADM NOV 0 0 91 174 1 1
ADM PDK1 0 0 150 169 1 2
ADM MMP3 0 0 155 206 1 1
ADM MYC 0 0 204 204 1 2
ADM FAIM 0 0 68 229 1 1
ADM KDM3A 0 0 243 242 1 1
ADM BDNF 0 0 170 169 1 2
ADM IL18 0 0 203 203 1 2
ADM CD44 0 0 120 152 1 2
ADM UTS2B 0 0 181 237 1 1
ADM MC3R 0 0 94 150 1 1
ADM HTR1B 0 0 134 193 1 1
ADM NT5E 0 0 160 206 1 1
ADM DIRC2 0 0 160 159 1 1
ADM NPY 0 0 455 458 1 1
ADM UBASH3B 0 0 59 154 1 1
ADM FURIN 0 0 170 169 1 1
ADM ATF3 0 0 112 169 1 2
ADM AGTRAP 0 0 171 214 1 1
ADM CDH5 0 0 323 323 1 1
ADM RETN 0 0 324 323 1 1
ADM CYB5A 0 0 0 205 1 1
ADM PDGFB 0 0 246 288 1 2
ADM EPHB4 0 0 143 178 1 1
ADM CNR1 0 0 91 187 1 1
ADM IFFO1 0 0 103 197 1 1
ADM PFKFB4 0 0 67 150 1 1
ADM PCSK1N 0 0 140 176 1 1
ADM THBS2 0 0 111 164 1 1
ADM TIGD2 0 0 134 175 1 1
ADM BTK 0 0 141 156 1 1
ADM SOCS1 0 0 61 569 1 1
ADM PAPPA 0 0 193 193 1 1
ADM DEFB4A 0 0 156 155 1 1
ADM WDFY3 0 0 0 244 1 2
ADM IGF1 0 0 392 404 1 2
ADM TNNT2 0 0 283 282 1 1
ADM GCG 0 500 402 688 1 1
ADM ADM5 0 0 459 459 1 1
ADM TNFAIP6 0 0 234 271 1 1
ADM STC1 0 0 134 192 1 1
ADM AGT 0 0 397 461 1 1
ADM VWF 0 0 232 231 1 1
ADM TYMP 0 0 323 323 1 1
ADM PROX1 0 0 167 184 1 1
ADM SLC2A3 0 0 211 275 1 1
ADM ADM2 0 300 871 923 1 1
ADM TNFRSF12A 0 0 75 179 1 1
ADM EIF5B 0 0 261 261 1 1
ADM NANP 0 0 243 242 1 1
ADM NPR3 0 0 213 213 1 1
ADM CHGA 0 0 293 312 1 1
ADM FGF2 0 0 414 434 1 2
ADM COL25A1 0 0 124 178 1 1
ADM STC2 0 0 134 168 1 1
ADM NGLY1 0 0 0 210 1 1
ADM EPO 0 0 458 457 1 2
ADM VEGFB 0 0 181 353 1 1
ADM TH 0 0 181 181 1 2
ADM KLK4 0 0 243 242 1 1
ADM C19orf10 0 0 103 259 1 1
ADM NPPA 0 0 564 564 1 1
ADM ANXA5 0 0 120 164 1 2
ADM NUS1 0 0 58 205 1 1
ADM PNOC 0 0 212 230 1 1
ADM RAPGEF4 0 0 184 183 1 1
ADM ARG2 0 0 124 161 1 1
ADM ECE1 0 0 329 345 1 1
ADM NGF 0 0 227 259 1 2
ADM CD34 0 0 186 186 1 2
ADM GAST 0 0 181 181 1 1
ADM GJA1 0 0 217 236 1 1
ADM CCK 0 0 260 372 1 1
ADM RAPGEF3 0 0 203 203 1 1
ADM IFNG 0 0 268 268 1 2
ADM IL11 0 0 175 175 1 1
ADM CREB1 0 0 166 165 1 2
ADM PDE5A 0 0 247 246 1 1
ADM CCL5 0 0 219 219 1 2
ADM CXCL10 0 0 203 203 1 2
ADM HAVCR1 0 0 213 213 1 1
ADM PFKFB3 0 0 150 375 1 2
ADM EDNRB 0 0 315 315 1 1
ADM GPRC5B 0 0 90 157 1 1
ADM KLKB1 0 0 162 161 1 1
ADM P4HA1 0 0 226 265 1 1
ADM NEFM 0 0 66 176 1 1
ADM RXFP1 0 0 165 253 1 1
ADM COL1A2 0 0 61 150 1 1
ADM SLC26A6 0 0 46 329 1 1
ADM ACE2 0 0 95 340 1 2
ADM NOS2 0 0 170 185 1 2
ADM INSL5 0 0 141 332 1 1
ADM VIP 0 500 560 778 1 1
ADM ENO1 0 0 147 166 1 1
ADM TLR4 0 0 193 210 1 2
ADM DUSP5 0 0 73 152 1 1
ADM ESM1 0 0 213 213 1 1
ADM GAPDH 0 0 294 294 1 2
ADM NOX4 0 0 161 161 1 2
ADM CST3 0 0 414 414 1 1
ADM HEYL 0 0 71 214 1 1
ADM ANKS6 0 0 70 167 1 1
ADM CFH 213 0 975 980 1 1
ADM LHX2 0 0 74 213 1 1
ADM CSF2 0 0 181 181 1 1
ADM PPARG 0 0 217 217 1 2
ADM ACKR3 0 0 362 362 1 1
ADM RAMP3 800 800 960 998 1 1
ADM NPR1 0 0 443 455 1 1
ADM APLN 0 0 391 390 1 1
ADM AKT1 0 0 392 416 1 2
ADM CALCR 0 800 817 965 1 1
ADM VCAM1 0 0 253 252 1 1
ADM CA9 0 0 260 323 1 1
ADM CD4 0 0 184 183 1 2
ADM KITLG 0 0 430 443 1 1
ADM UCN 0 0 450 450 1 1
ADM ACKR4 0 0 90 152 1 1
ADM CEP85 0 0 100 153 1 1
ADM PTHLH 0 500 263 618 1 1
ADM P4HA2 0 0 136 179 1 1
ADM ADCYAP1 0 500 337 654 1 1
ADM TGFB1 0 0 263 264 1 2
ADM MC4R 0 0 95 192 1 1
ADM DCLK3 0 0 292 292 1 1
ADM CXCR2 0 0 158 157 1 1
ADM RHO 0 0 166 165 1 2
ADM CSN3 0 0 163 163 1 1
ADM CACNA2D2 0 0 55 150 1 1
ADM F2R 0 0 187 187 1 1
ADM TAF5L 0 0 70 231 1 1
ADM UCN3 0 0 139 198 1 1
ADM BNIP3L 0 0 125 181 1 2
ADM ADORA2B 0 0 227 226 1 1
ADM CCBE1 0 0 136 190 1 1
ADM VIPR2 0 0 288 303 1 1
ADM BET1L 0 0 0 286 1 1
ADM CTNNB1 0 0 155 154 1 2
ADM TRPV1 0 0 234 234 1 2
ADM LIPE 0 0 154 153 1 1
ADM EGR1 0 0 208 225 1 2
ADM CXCL8 0 0 392 421 1 2
ADM NDRG1 0 0 161 186 1 1
ADM NRG1 0 0 145 164 1 2
ADM FSHB 0 500 0 499 1 1
ADM HMOX1 0 0 323 374 1 2
ADM MRVI1 0 0 126 375 1 1
ADM HCLS1 0 0 66 321 1 1
ADM HIF1A 0 0 547 547 1 2
ADM EDN1 213 0 710 773 1 1
ADM KDR 0 0 291 303 1 2
ADM AK4 0 0 113 194 1 1
ADM BAG3 0 0 76 164 1 2
ADM IL1B 0 0 458 471 1 2
ADM AGTR2 0 0 181 276 1 1
ADM UCN2 0 0 150 186 1 1
ADM HTR1D 0 0 90 167 1 1
ADM FLT1 0 0 294 294 1 1
ADM VHL 0 0 166 172 1 2
ADM OCLN 0 0 180 179 1 1
ADM LGALS3 0 0 395 424 1 2
ADM MIF 0 0 209 209 1 2
ADM ACTN4 0 0 57 170 1 1
ADM CDKN3 0 0 70 164 1 1
ADM TNFRSF1A 0 0 135 160 1 1
ADM PRKG1 0 0 142 192 1 1
ADM MPO 0 0 258 258 1 2
ADM GPHB5 0 500 0 499 1 1
ADM RNASE7 0 0 261 334 1 1
ADM GAD1 0 0 49 218 1 1
ADM IL6 0 0 517 545 1 2
ADM DPYS 336 0 0 336 1 1
ADM LYVE1 0 0 245 250 1 1
ADM HILPDA 0 0 134 172 1 1
ADM OXT 0 0 253 252 1 1
ADM TRPV2 0 0 188 188 1 1
ADM APOE 0 0 170 169 1 2
ADM MTOR 0 0 155 154 1 2
ADM AP1B1 0 0 236 288 1 1
ADM TNFSF11 0 0 181 181 1 2
ADM MB 0 0 150 243 1 2
ADM BPI 0 0 124 258 1 1
ADM CYR61 0 0 141 227 1 1
ADM CRCP 0 0 725 728 1 1
ADM CXCR4 0 0 294 294 1 2
ADM FGF13 0 0 181 181 1 1
ADM GCA 0 0 218 218 1 1
ADM GPHA2 0 500 0 499 1 1
ADM CD40LG 0 0 108 201 1 1
ADM VNN1 0 0 194 215 1 1
ADM SCD 0 0 67 164 1 1
ADM LRRC15 0 0 124 208 1 1
ADM MMP1 0 0 194 241 1 1
ADM SRC 0 0 181 195 1 2
ADM NOTCH1 0 0 363 363 1 2
ADM ADAM12 0 0 137 173 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0031700 Molecular Function adrenomedullin receptor binding enables IBA
GO:0031700 Molecular Function adrenomedullin receptor binding enables IDA
GO:0005179 Molecular Function hormone activity enables IEA
GO:0005102 Molecular Function signaling receptor binding enables TAS
GO:0002031 Biological Process G protein-coupled receptor internalization involved_in IDA
GO:0007189 Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway involved_in IBA
GO:0007189 Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway involved_in IDA
GO:1990410 Biological Process adrenomedullin receptor signaling pathway involved_in IBA
GO:1990410 Biological Process adrenomedullin receptor signaling pathway involved_in IDA
GO:0008209 Biological Process androgen metabolic process involved_in IEA
GO:0031100 Biological Process animal organ regeneration involved_in IEA
GO:0060670 Biological Process branching involved in labyrinthine layer morphogenesis involved_in IEA
GO:0019933 Biological Process cAMP-mediated signaling involved_in IEA
GO:0048589 Biological Process developmental growth involved_in IEA
GO:0007565 Biological Process female pregnancy involved_in IEA
GO:0007507 Biological Process heart development involved_in IEA
GO:0006954 Biological Process inflammatory response involved_in TAS
GO:0008285 Biological Process negative regulation of cell population proliferation involved_in IEA
GO:0043116 Biological Process negative regulation of vascular permeability involved_in IEA
GO:0045906 Biological Process negative regulation of vasoconstriction involved_in IDA
GO:0001843 Biological Process neural tube closure involved_in IEA
GO:0031102 Biological Process neuron projection regeneration involved_in IEA
GO:0042475 Biological Process odontogenesis of dentin-containing tooth involved_in IEA
GO:0045766 Biological Process positive regulation of angiogenesis involved_in IEA
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IEA
GO:0008284 Biological Process positive regulation of cell population proliferation involved_in IEA
GO:0007204 Biological Process positive regulation of cytosolic calcium ion concentration involved_in IEA
GO:0010460 Biological Process positive regulation of heart rate involved_in IBA
GO:0010460 Biological Process positive regulation of heart rate involved_in IDA
GO:2000184 Biological Process positive regulation of progesterone biosynthetic process involved_in TAS
GO:2001214 Biological Process positive regulation of vasculogenesis involved_in IEA
GO:0031623 Biological Process receptor internalization involved_in IDA
GO:0003073 Biological Process regulation of systemic arterial blood pressure involved_in IBA
GO:0003073 Biological Process regulation of systemic arterial blood pressure involved_in IDA
GO:0002026 Biological Process regulation of the force of heart contraction involved_in IEA
GO:0035809 Biological Process regulation of urine volume involved_in IDA
GO:0051384 Biological Process response to glucocorticoid involved_in IEA
GO:0001666 Biological Process response to hypoxia involved_in IEA
GO:0032868 Biological Process response to insulin involved_in IEA
GO:0032496 Biological Process response to lipopolysaccharide involved_in IEA
GO:0042594 Biological Process response to starvation involved_in IEA
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0097084 Biological Process vascular associated smooth muscle cell development involved_in IEA
GO:0001570 Biological Process vasculogenesis involved_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space is_active_in IBA
GO:0005615 Cellular Component extracellular space located_in IDA
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Signaling by GPCR Reactome R-HSA-372790
Class B/2 (Secretin family receptors) Reactome R-HSA-373080
GPCR downstream signalling Reactome R-HSA-388396
G alpha (s) signalling events Reactome R-HSA-418555
Calcitonin-like ligand receptors Reactome R-HSA-419812
GPCR ligand binding Reactome R-HSA-500792
Complement system (WP2806) WikiPathways WP2806_r116569
Myometrial relaxation and contraction pathways (WP289) WikiPathways WP289_r122789
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001124 3 mRNA None NC_000011 Reference