HAdb 2.0 is available now!

TICAM1

TIR domain containing adaptor molecule 1
General Information
Name TIR domain containing adaptor molecule 1
Alias
  • TIR domain-containing adapter molecule 1
  • TIR domain containing adaptor inducing interferon-beta
  • TIR domain-containing adapter protein inducing IFN-beta
  • proline-rich, vinculin and TIR domain-containing protein B
  • putative NF-kappa-B-activating protein 502H
  • toll like receptor adaptor molecule 1
  • toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Gene_family TIR domain containing
organism Homo sapiens
entrez_id 148022
location 19p13.3
transcript_count 4
exon_count 3
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
    Stringdb TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively
    nextProt Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TICAM1 BioGRID TGFBRAP1 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID INPPL1 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID GPX1 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID DIS3L2 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID VPS11 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID CARM1 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID PELI1 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
TICAM1 BioGRID RIPK1 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID CASP8 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID RNF144B GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TICAM2 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID KCTD10 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TBK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TICAM1 BioGRID USP19 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TRAF3 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TLR4 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TLR3 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID ABCF1 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TRIM8 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TICAM1 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
TICAM1 BioGRID FOSL1 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TICAM1 BioGRID CEP170P1 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID Immt GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID CDCA5 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID KIF21B GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID MKNK2 GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID IRF3 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID CFLAR GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TICAM1 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID SYK GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TRIM38 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID PIAS4 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID SRSF4 GeneID BioGRID Two-hybrid
TICAM1 BioGRID MAVS GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Two-hybrid
TICAM1 BioGRID TRAF1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TICAM1 BioGRID TRIM56 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TRAF4 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TNFAIP3 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID TRAF5 GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID CBLB GeneID BioGRID Affinity Capture-Western
TICAM1 BioGRID UBQLN1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TICAM1 BioGRID TANK GeneID BioGRID Affinity Capture-MS
TICAM1 BioGRID RNF216 GeneID BioGRID Affinity Capture-Western
TICAM1 None TICAM2 GeneID HPRD
TICAM1 None MAVS GeneID HPRD
TICAM1 None AZI2 GeneID HPRD
TICAM1 None RIPK3 GeneID HPRD
TICAM1 None PIAS4 GeneID HPRD
TICAM1 None TIRAP GeneID HPRD
TICAM1 None TRAM1 GeneID HPRD
TICAM1 None IKBKE GeneID HPRD
TICAM1 None IRF7 GeneID HPRD
TICAM1 None TBK1 GeneID HPRD
TICAM1 None IRF3 GeneID HPRD
TICAM1 None RIPK1 GeneID HPRD
TICAM1 None TLR3 GeneID HPRD
TICAM1 None TLR2 GeneID HPRD
TICAM1 None TRAF4 GeneID HPRD
TICAM1 None TRAF6 GeneID HPRD
TICAM1 None TRAF3 GeneID HPRD
TICAM1 None TRAF1 GeneID HPRD
TICAM1 None TNFAIP3 GeneID HPRD
TICAM1 None PIK3CA GeneID HPRD
TICAM1 BioGRID RIPK3 GeneID BioGRID Affinity Capture-Western
TICAM1 None None None BIND An unspecified isoform of TRIF interacts with A20. This interaction was modeled on a demonstrated interaction between TRIF from an unspecified species and A20 from an unspecified species.
TICAM1 None None None BIND An unspecified isoform of TRIF interacts with TRAF6. This interaction was modeled on a demonstrated interaction between TRIF from an unspecified species and TRAF from an unspecified species.
TICAM1 Protein TBK1 GeneID BIND TRIF interacts with TBK1.
TICAM1 Protein TRAF6 GeneID BIND TRIF interacts with TRAF6.
TICAM1 None None None BIND TIRP interacts with TRIF.
StringDB
A B experiments database textmining combined score hadb nhadb
TICAM1 BCL3 0 0 0 303 1 1
TICAM1 FOSL1 270 0 0 313 1 1
TICAM1 PNPLA2 0 0 0 151 1 2
TICAM1 PDCD10 0 0 60 158 1 1
TICAM1 CD40 0 0 324 328 1 2
TICAM1 NLRX1 0 0 486 516 1 2
TICAM1 ACTB 0 0 292 292 1 2
TICAM1 JUNB 0 0 52 204 1 1
TICAM1 DPP7 0 0 0 155 1 1
TICAM1 TRAM1 213 0 125 377 1 1
TICAM1 SQSTM1 0 0 125 163 1 2
TICAM1 MMP9 0 0 113 198 1 2
TICAM1 MAPK3 0 0 124 158 1 2
TICAM1 IFNAR2 0 0 282 282 1 1
TICAM1 TNFRSF14 0 0 55 165 1 1
TICAM1 BAX 0 0 108 224 1 2
TICAM1 UBE2N 0 900 248 921 1 1
TICAM1 TLR5 0 0 519 539 1 1
TICAM1 ZBTB7B 0 0 0 181 1 1
TICAM1 PTPRC 0 0 175 175 1 1
TICAM1 RAB35 0 0 0 159 1 1
TICAM1 BCL10 0 0 180 186 1 1
TICAM1 MLKL 0 0 456 476 1 2
TICAM1 UNC93B1 0 0 418 522 1 1
TICAM1 ICAM1 0 0 203 250 1 2
TICAM1 RFTN1 0 0 223 252 1 1
TICAM1 OCA2 0 0 180 179 1 1
TICAM1 SH3TC1 0 0 0 151 1 1
TICAM1 PVRL2 0 0 0 213 1 1
TICAM1 NFKBIE 0 0 140 268 1 1
TICAM1 WDFY2 0 0 0 154 1 1
TICAM1 IFNK 0 0 112 205 1 1
TICAM1 NFKBIL1 0 0 146 221 1 1
TICAM1 LTA 0 0 162 238 1 1
TICAM1 CCR5 0 0 165 185 1 1
TICAM1 MEX3B 0 0 478 478 1 1
TICAM1 EIF2AK2 0 0 225 258 1 2
TICAM1 CD8A 0 0 367 367 1 1
TICAM1 ADAM8 0 0 0 210 1 1
TICAM1 WDFY1 0 0 454 535 1 1
TICAM1 RIPK2 0 0 294 322 1 2
TICAM1 CNPY3 0 0 186 186 1 1
TICAM1 TCIRG1 0 0 0 200 1 1
TICAM1 TRIM38 270 0 147 350 1 1
TICAM1 PVR 0 0 60 562 1 1
TICAM1 CASP1 0 0 450 482 1 2
TICAM1 REXO1 0 0 0 156 1 1
TICAM1 ZFP36 0 0 63 158 1 1
TICAM1 TNFSF10 0 0 181 198 1 2
TICAM1 MAP2K3 0 0 120 233 1 1
TICAM1 PADI4 0 0 66 159 1 1
TICAM1 JAK3 0 0 74 175 1 1
TICAM1 IL10RA 0 0 108 185 1 1
TICAM1 ENSG00000173366 0 0 715 723 1 1
TICAM1 JUN 0 0 310 335 1 2
TICAM1 TMEM173 0 0 454 487 1 1
TICAM1 TYK2 0 0 244 312 1 1
TICAM1 ZNF524 0 0 0 214 1 1
TICAM1 IRF2 0 0 162 181 1 1
TICAM1 TRIM5 0 0 155 154 1 1
TICAM1 ISG20 0 0 194 300 1 1
TICAM1 DDX1 0 0 373 373 1 1
TICAM1 CEBPD 0 0 66 173 1 1
TICAM1 NFYA 0 0 0 207 1 1
TICAM1 IER3 0 0 90 288 1 1
TICAM1 WASH2P 0 0 166 165 1 1
TICAM1 TRAF6 872 800 965 999 1 2
TICAM1 RNF144B 270 0 0 270 1 1
TICAM1 RPS6KA4 0 0 0 165 1 1
TICAM1 TLR7 0 0 661 674 1 2
TICAM1 DHX36 0 0 656 656 1 1
TICAM1 GADD45B 0 0 0 166 1 1
TICAM1 PLAU 0 0 0 162 1 1
TICAM1 IL17A 0 0 261 261 1 2
TICAM1 PCSK1 0 0 249 248 1 1
TICAM1 PELI1 0 0 241 293 1 1
TICAM1 KIAA0391 0 0 62 177 1 1
TICAM1 MAPK8 0 0 218 218 1 2
TICAM1 LDB3 0 0 0 191 1 1
TICAM1 DNAH5 0 0 51 156 1 1
TICAM1 OSBPL7 0 0 107 151 1 1
TICAM1 DNASE2 0 0 123 210 1 1
TICAM1 BATF3 0 0 122 154 1 1
TICAM1 DIABLO 0 0 193 193 1 2
TICAM1 IFIH1 0 0 662 696 1 1
TICAM1 FBXO11 0 0 47 210 1 1
TICAM1 DAPK3 0 0 0 179 1 2
TICAM1 MX2 0 0 159 158 1 1
TICAM1 IL2RG 0 0 54 282 1 1
TICAM1 CISH 0 0 142 204 1 1
TICAM1 PTGER4 0 0 85 179 1 1
TICAM1 TBC1D2 0 0 0 165 1 1
TICAM1 FAM26F 0 0 107 162 1 1
TICAM1 RNF31 0 0 170 227 1 1
TICAM1 CCL4 0 0 218 240 1 1
TICAM1 CEACAM1 0 0 328 328 1 1
TICAM1 IL1A 0 0 322 342 1 1
TICAM1 MAVS 270 0 683 767 1 2
TICAM1 CPTP 0 0 0 158 1 1
TICAM1 TRADD 0 0 503 589 1 1
TICAM1 PIK3AP1 0 0 115 174 1 1
TICAM1 AGER 0 0 134 161 1 2
TICAM1 DDX41 0 0 390 428 1 1
TICAM1 DDX58 0 0 681 687 1 1
TICAM1 AIM2 0 0 379 379 1 2
TICAM1 TRIM21 0 0 181 211 1 1
TICAM1 BCL2L13 0 0 81 165 1 2
TICAM1 MB21D1 0 0 464 463 1 1
TICAM1 IL4 0 0 266 266 1 1
TICAM1 SMAD3 0 0 48 168 1 2
TICAM1 BIRC3 0 900 166 916 1 1
TICAM1 IFNA6 0 0 437 437 1 1
TICAM1 ROBO3 0 0 415 414 1 1
TICAM1 CD276 0 0 162 161 1 1
TICAM1 LRRFIP1 0 0 190 211 1 1
TICAM1 GNB2 0 0 0 155 1 1
TICAM1 CCL2 0 0 324 323 1 2
TICAM1 ZNF653 0 0 0 151 1 1
TICAM1 ALB 0 0 171 171 1 2
TICAM1 CASP8 270 900 542 964 1 2
TICAM1 CASP7 0 0 167 191 1 1
TICAM1 TYROBP 0 0 107 415 1 1
TICAM1 GATA3 0 0 70 169 1 1
TICAM1 MUC5AC 0 0 92 204 1 1
TICAM1 STAT3 0 0 231 230 1 2
TICAM1 TRIM8 270 0 45 315 1 1
TICAM1 JAK2 0 0 117 295 1 2
TICAM1 NLRC5 0 0 203 250 1 1
TICAM1 RAD9A 0 0 0 190 1 1
TICAM1 LY86 0 0 216 248 1 1
TICAM1 RALBP1 0 0 96 260 1 1
TICAM1 IRAK1 0 800 601 927 1 1
TICAM1 CSF3 0 0 202 221 1 1
TICAM1 MUC5B 0 0 81 195 1 1
TICAM1 CARD9 0 0 218 282 1 1
TICAM1 TRAF1 677 0 453 839 1 1
TICAM1 MAP3K7 0 600 324 727 1 2
TICAM1 NLRP4 0 0 135 163 1 1
TICAM1 LCP2 0 0 66 247 1 1
TICAM1 EDARADD 0 0 123 160 1 1
TICAM1 ZBP1 0 0 483 494 1 1
TICAM1 NFKBIZ 0 0 113 230 1 1
TICAM1 IRF9 0 0 321 337 1 1
TICAM1 SARM1 270 600 807 943 1 1
TICAM1 FADD 0 900 422 942 1 2
TICAM1 TSLP 0 0 127 159 1 1
TICAM1 CFLAR 270 900 293 944 1 2
TICAM1 MYD88 0 0 893 909 1 2
TICAM1 TLR1 0 0 564 623 1 1
TICAM1 PGAM5 0 0 183 183 1 1
TICAM1 ZNF865 0 0 0 213 1 1
TICAM1 CD80 0 0 294 311 1 2
TICAM1 RBCK1 0 0 117 198 1 1
TICAM1 DHX58 0 0 466 521 1 1
TICAM1 MAP3K8 0 0 224 267 1 1
TICAM1 MKNK2 151 0 0 201 1 1
TICAM1 OAS3 0 0 107 150 1 1
TICAM1 SMAD4 0 0 0 206 1 2
TICAM1 CASP10 0 900 95 907 1 1
TICAM1 MEFV 0 0 297 297 1 1
TICAM1 TRAF2 677 0 170 762 1 2
TICAM1 TAB1 0 600 369 756 1 1
TICAM1 MX1 0 0 318 317 1 1
TICAM1 SBNO2 0 0 0 183 1 1
TICAM1 PIK3CA 213 0 0 213 1 2
TICAM1 IL1R1 0 0 524 536 1 1
TICAM1 CBLB 270 0 0 345 1 1
TICAM1 RARRES3 0 0 82 180 1 1
TICAM1 IKBKAP 0 0 0 215 1 1
TICAM1 IL15 0 0 155 154 1 1
TICAM1 ITGAE 0 0 181 181 1 1
TICAM1 MYC 0 0 148 168 1 2
TICAM1 RNF125 0 0 431 431 1 1
TICAM1 PARP12 0 0 72 262 1 1
TICAM1 IFNA1 0 0 560 560 1 1
TICAM1 PPIP5K1 0 0 398 398 1 1
TICAM1 IL18 0 0 392 392 1 2
TICAM1 TAB2 0 600 413 758 1 2
TICAM1 AZI2 213 0 301 426 1 1
TICAM1 TREM1 0 0 164 188 1 1
TICAM1 UBE2D1 0 900 0 900 1 1
TICAM1 SMAD2 0 0 48 211 1 2
TICAM1 TLR4 675 800 987 999 1 2
TICAM1 TMED7 0 0 73 166 1 1
TICAM1 SPSB1 0 0 82 164 1 1
TICAM1 TMEM102 0 0 0 151 1 1
TICAM1 ABCF1 270 0 0 270 1 1
TICAM1 GAPDH 0 0 294 294 1 2
TICAM1 CD14 0 600 87 648 1 1
TICAM1 CD83 0 0 155 185 1 1
TICAM1 NOS2 0 0 150 173 1 2
TICAM1 TRIM25 0 0 413 436 1 1
TICAM1 CLNK 0 0 210 210 1 1
TICAM1 TLR10 0 0 408 457 1 1
TICAM1 CLEC7A 0 0 290 290 1 1
TICAM1 TAB3 0 600 391 766 1 1
TICAM1 STAT4 0 0 92 192 1 1
TICAM1 NFKB1 0 0 260 323 1 2
TICAM1 TEC 0 0 0 174 1 1
TICAM1 ENSG00000026036 0 0 100 161 1 1
TICAM1 RELA 0 0 323 382 1 2
TICAM1 BCL2L1 0 0 137 299 1 2
TICAM1 CARM1 423 0 0 440 1 2
TICAM1 CLCF1 0 0 0 154 1 1
TICAM1 TNFSF13 0 0 63 159 1 1
TICAM1 LGALS9 0 0 61 150 1 1
TICAM1 PHEX 0 0 0 206 1 1
TICAM1 ODF3B 0 0 0 152 1 1
TICAM1 UBE2D3 0 900 0 900 1 1
TICAM1 IFNG 0 0 184 235 1 2
TICAM1 BIRC2 0 900 211 917 1 1
TICAM1 DHX9 0 0 190 308 1 1
TICAM1 CCL5 0 0 416 416 1 2
TICAM1 GSDMD 0 0 203 244 1 2
TICAM1 ZNF628 0 0 0 183 1 1
TICAM1 NLRC3 0 0 134 167 1 1
TICAM1 IL6 0 0 509 526 1 2
TICAM1 STAT1 0 0 420 438 1 2
TICAM1 GZMB 0 0 153 152 1 1
TICAM1 TNFRSF1A 0 0 435 463 1 1
TICAM1 SECTM1 0 0 0 192 1 1
TICAM1 TRAF4 270 0 189 400 1 1
TICAM1 CXCR4 0 0 129 159 1 2
TICAM1 CD40LG 0 0 450 450 1 1
TICAM1 PTGS1 0 0 45 157 1 1
TICAM1 CBY1 0 0 46 210 1 1
TICAM1 NLRP1 0 0 230 229 1 1
TICAM1 RFXAP 0 0 0 173 1 1
TICAM1 DDX21 0 0 335 335 1 1
TICAM1 OLFM2 0 0 68 159 1 1
TICAM1 ADAR 0 0 140 186 1 1
TICAM1 ASPA 0 0 67 218 1 1
TICAM1 MFN2 0 0 0 188 1 2
TICAM1 IFNA4 0 0 411 410 1 1
TICAM1 TNFRSF1B 0 0 113 188 1 1
TICAM1 IKBKE 213 600 459 853 1 1
TICAM1 OAS1 0 0 226 245 1 1
TICAM1 TRAF5 270 0 233 432 1 1
TICAM1 IL1B 0 0 517 546 1 2
TICAM1 CDCA5 198 0 0 198 1 1
TICAM1 CXCL8 0 0 391 428 1 2
TICAM1 UBE2V1 0 900 287 926 1 1
TICAM1 CTSZ 0 0 0 214 1 1
TICAM1 CXCL1 0 0 246 286 1 2
TICAM1 APCS 0 0 0 167 1 1
TICAM1 NLRP3 0 0 427 426 1 2
TICAM1 REL 0 0 267 283 1 2
TICAM1 DHX29 0 0 159 158 1 1
TICAM1 PGLYRP1 0 0 134 168 1 1
TICAM1 CCDC71 0 0 139 266 1 1
TICAM1 CASP3 0 0 210 210 1 2
TICAM1 PTGS2 0 0 242 279 1 2
TICAM1 TNFSF13B 0 0 148 381 1 1
TICAM1 PPM1B 0 0 194 230 1 1
TICAM1 IL13 0 0 189 189 1 2
TICAM1 ATG12 0 0 151 150 1 2
TICAM1 TRIM56 270 0 95 311 1 1
TICAM1 NR2C2 0 0 141 229 1 1
TICAM1 TREML2 0 0 50 365 1 1
TICAM1 GUSB 0 0 73 232 1 1
TICAM1 RPS27A 0 900 46 901 1 1
TICAM1 EHBP1L1 0 0 0 213 1 1
TICAM1 ITGAX 0 0 293 293 1 1
TICAM1 SALL4 0 0 0 206 1 1
TICAM1 S100A12 0 0 56 150 1 1
TICAM1 NRROS 0 0 108 163 1 1
TICAM1 CHUK 0 600 456 776 1 1
TICAM1 ECSIT 0 0 171 191 1 1
TICAM1 CIITA 0 0 181 181 1 1
TICAM1 NOD2 0 0 413 446 1 2
TICAM1 AMZ1 0 0 113 199 1 1
TICAM1 CEBPB 0 0 113 204 1 2
TICAM1 UBE2L6 0 0 296 296 1 1
TICAM1 JOSD2 0 0 0 151 1 1
TICAM1 CDO1 0 0 45 205 1 1
TICAM1 ATG16L1 0 0 247 246 1 2
TICAM1 RIPK1 675 900 961 998 1 2
TICAM1 CSF1 0 0 169 218 1 1
TICAM1 FASLG 0 0 177 177 1 1
TICAM1 FBRS 0 0 0 153 1 1
TICAM1 FOS 0 0 205 205 1 2
TICAM1 YWHAZ 0 0 442 442 1 1
TICAM1 SOCS3 0 0 171 201 1 1
TICAM1 IL15RA 0 0 74 264 1 1
TICAM1 STAT5A 0 0 86 226 1 1
TICAM1 IRG1 0 0 134 164 1 1
TICAM1 IFNL3 0 0 288 288 1 1
TICAM1 PTPN11 0 900 90 907 1 1
TICAM1 TNIP1 0 0 67 174 1 1
TICAM1 IRAK3 0 0 381 404 1 1
TICAM1 SIGIRR 0 0 233 391 1 1
TICAM1 IFNGR1 0 0 258 258 1 1
TICAM1 HLA-B 0 0 65 161 1 1
TICAM1 BECN1 0 0 404 491 1 2
TICAM1 AKIRIN2 0 0 113 203 1 1
TICAM1 ZC3HAV1 0 0 82 189 1 1
TICAM1 TLR6 0 0 518 569 1 1
TICAM1 IL2 0 0 193 193 1 1
TICAM1 ITGA2 0 0 0 250 1 1
TICAM1 ZMYND11 0 0 428 428 1 1
TICAM1 MAPK11 0 0 70 197 1 1
TICAM1 TLR2 213 800 800 967 1 2
TICAM1 TOLLIP 0 0 585 637 1 1
TICAM1 ERF 0 0 0 177 1 1
TICAM1 TRAF3 766 800 961 998 1 2
TICAM1 IVNS1ABP 0 0 169 169 1 1
TICAM1 CD86 0 0 322 341 1 1
TICAM1 IFNA13 0 0 166 165 1 1
TICAM1 TBKBP1 0 0 282 308 1 1
TICAM1 CFB 0 0 104 177 1 1
TICAM1 CD81 0 0 144 165 1 1
TICAM1 SHARPIN 0 0 150 190 1 1
TICAM1 NOD1 0 0 377 407 1 2
TICAM1 CARD11 0 0 112 344 1 1
TICAM1 STAT2 0 0 325 348 1 1
TICAM1 CXCR3 0 0 134 155 1 1
TICAM1 IRF1 0 0 334 348 1 2
TICAM1 HLA-C 0 0 60 152 1 1
TICAM1 SASH3 0 0 81 265 1 1
TICAM1 ABHD16B 0 0 0 175 1 1
TICAM1 ATG5 0 0 171 171 1 2
TICAM1 SH2D3A 0 0 194 194 1 1
TICAM1 BCL2L14 0 0 46 173 1 1
TICAM1 TLR8 0 0 596 609 1 1
TICAM1 EYA4 0 0 61 224 1 1
TICAM1 ITGAM 0 0 273 299 1 1
TICAM1 IFNB1 0 0 806 806 1 1
TICAM1 HMGB1 0 0 324 323 1 2
TICAM1 IRF5 0 0 358 389 1 1
TICAM1 UBE2D2 0 900 0 900 1 1
TICAM1 SPI1 0 0 150 197 1 1
TICAM1 ABCD1 0 0 0 196 1 1
TICAM1 MAPK8IP3 0 0 141 229 1 1
TICAM1 CTSB 0 0 122 154 1 2
TICAM1 MCL1 0 0 83 182 1 2
TICAM1 GMIP 0 0 0 173 1 1
TICAM1 ELF4 0 0 0 197 1 1
TICAM1 IL10RB 0 0 170 205 1 1
TICAM1 IKBKG 0 600 404 768 1 1
TICAM1 RARA 0 0 57 155 1 2
TICAM1 ELANE 0 0 94 167 1 1
TICAM1 TBX21 0 0 97 205 1 1
TICAM1 RIN3 0 0 0 151 1 1
TICAM1 UBC 0 900 0 900 1 2
TICAM1 ISG15 0 0 386 408 1 2
TICAM1 NFKBIB 0 0 167 203 1 1
TICAM1 IL22RA1 0 0 63 232 1 1
TICAM1 USP18 0 0 202 225 1 1
TICAM1 KCNN4 0 0 0 152 1 1
TICAM1 NUDT18 0 0 0 153 1 1
TICAM1 CCL20 0 0 163 203 1 1
TICAM1 IL10 0 0 392 392 1 2
TICAM1 PFN2 0 0 0 248 1 1
TICAM1 IRAK4 0 800 564 923 1 1
TICAM1 CXCL2 0 0 203 237 1 1
TICAM1 TRAT1 0 0 154 153 1 1
TICAM1 OTUD5 0 0 174 198 1 1
TICAM1 RPL38 0 0 44 208 1 1
TICAM1 HLA-A 0 0 125 175 1 1
TICAM1 RNF220 0 0 73 165 1 1
TICAM1 CCL3 0 0 243 272 1 1
TICAM1 THBD 0 0 159 257 1 1
TICAM1 MAPK14 0 0 150 241 1 2
TICAM1 CLEC4E 0 0 186 186 1 1
TICAM1 GNB4 0 0 52 183 1 1
TICAM1 FCGR2A 0 0 161 161 1 1
TICAM1 UBA52 0 900 0 901 1 1
TICAM1 EFHD2 0 0 0 151 1 1
TICAM1 ZC3H12A 0 0 95 238 1 1
TICAM1 SYK 270 0 243 494 1 2
TICAM1 NFKBIA 0 0 393 416 1 2
TICAM1 FTSJ3 0 0 67 157 1 1
TICAM1 TRIM47 0 0 0 157 1 1
TICAM1 CASP5 0 0 127 164 1 1
TICAM1 TRAF7 0 0 150 204 1 1
TICAM1 ACSL4 0 0 57 203 1 1
TICAM1 TRAFD1 0 0 538 538 1 1
TICAM1 SCAF1 0 0 83 166 1 1
TICAM1 STX11 0 0 0 151 1 1
TICAM1 TESK1 0 0 0 165 1 1
TICAM1 UBB 0 900 0 900 1 1
TICAM1 BAK1 0 0 112 247 1 2
TICAM1 BCL2 0 0 44 221 1 2
TICAM1 SCX 0 0 53 193 1 1
TICAM1 EPDR1 0 0 61 152 1 1
TICAM1 IFI44 0 0 113 157 1 1
TICAM1 RNASEL 0 0 323 333 1 1
TICAM1 CTLA4 0 0 167 167 1 2
TICAM1 KCTD10 270 0 73 294 1 1
TICAM1 FLT3LG 0 0 57 158 1 1
TICAM1 CD274 0 0 170 251 1 2
TICAM1 BCL2L2 0 0 0 170 1 1
TICAM1 IFIT2 0 0 261 261 1 1
TICAM1 IRAK2 0 600 504 811 1 1
TICAM1 DDX60 0 0 282 308 1 1
TICAM1 SERPINE1 0 0 0 206 1 1
TICAM1 IDUA 0 0 47 325 1 1
TICAM1 MINK1 0 0 48 178 1 1
TICAM1 SOCS1 0 0 246 274 1 1
TICAM1 RNF41 0 0 166 288 1 1
TICAM1 BTK 0 0 222 353 1 1
TICAM1 IRF7 213 800 618 942 1 1
TICAM1 CSF1R 0 0 134 159 1 1
TICAM1 USP19 270 0 55 302 1 1
TICAM1 ATF3 0 0 150 172 1 2
TICAM1 IFNL1 0 0 209 209 1 1
TICAM1 BCL2A1 0 0 95 537 1 1
TICAM1 IFI16 0 0 294 319 1 1
TICAM1 IFNL2 0 0 195 195 1 1
TICAM1 RELB 0 0 235 370 1 2
TICAM1 NFKB2 0 0 261 322 1 1
TICAM1 TNFAIP3 270 0 252 488 1 2
TICAM1 IFNAR1 0 0 556 556 1 1
TICAM1 DDX3X 0 0 323 323 1 1
TICAM1 RNF135 0 0 184 183 1 1
TICAM1 CD209 0 0 205 205 1 1
TICAM1 NAIP 0 0 153 152 1 1
TICAM1 IL1RN 0 0 108 173 1 1
TICAM1 TIRAP 213 0 751 830 1 1
TICAM1 TNF 0 0 517 545 1 2
TICAM1 TANK 409 600 704 923 1 2
TICAM1 IFNLR1 0 0 230 229 1 1
TICAM1 RNF216 270 0 97 317 1 1
TICAM1 IKBKB 0 600 455 776 1 2
TICAM1 NLRC4 0 0 267 289 1 2
TICAM1 APOL3 0 0 81 157 1 1
TICAM1 FGFR1 0 0 0 206 1 1
TICAM1 WDTC1 0 0 74 192 1 1
TICAM1 CD4 0 0 342 342 1 2
TICAM1 CSF2 0 0 294 307 1 1
TICAM1 LY96 0 600 556 825 1 1
TICAM1 AKT1 0 0 204 245 1 2
TICAM1 GBP2 0 0 123 200 1 1
TICAM1 RNASET2 0 0 123 155 1 1
TICAM1 BBC3 0 0 107 157 1 2
TICAM1 UBA7 0 0 74 169 1 1
TICAM1 IRF3 462 800 754 980 1 2
TICAM1 TLR9 0 800 634 925 1 2
TICAM1 MAFK 0 0 0 213 1 1
TICAM1 SQRDL 0 0 0 154 1 1
TICAM1 MAP3K1 0 0 208 219 1 1
TICAM1 PYCARD 0 0 260 277 1 2
TICAM1 CYLD 0 0 275 275 1 1
TICAM1 MALT1 0 0 170 169 1 1
TICAM1 CXCL10 0 0 427 447 1 2
TICAM1 DDX56 0 0 377 377 1 1
TICAM1 PDLIM2 0 0 166 167 1 1
TICAM1 UBQLN1 270 0 0 270 1 1
TICAM1 IFNGR2 0 0 134 161 1 1
TICAM1 RNPEPL1 0 0 0 175 1 1
TICAM1 STAT6 0 0 119 282 1 1
TICAM1 ARHGAP27 0 0 0 172 1 1
TICAM1 NAGLU 0 0 56 290 1 1
TICAM1 CD180 0 0 181 253 1 1
TICAM1 TLR3 766 900 988 999 1 2
TICAM1 RSAD2 0 0 240 304 1 1
TICAM1 PARP9 0 0 49 220 1 1
TICAM1 LGALS3 0 0 92 171 1 2
TICAM1 RAG1 0 0 113 156 1 1
TICAM1 SRC 0 0 193 267 1 2
TICAM1 IRF8 0 0 170 200 1 1
TICAM1 KRTAP8-1 0 0 90 193 1 1
TICAM1 PARP10 0 0 0 215 1 1
TICAM1 RIPK3 270 800 580 938 1 2
TICAM1 ZNF70 0 0 170 202 1 1
TICAM1 IFIT1 0 0 390 390 1 1
TICAM1 STAT5B 0 0 75 167 1 1
TICAM1 ARHGAP15 0 0 215 392 1 1
TICAM1 TGFB1 0 0 57 167 1 2
TICAM1 JAK1 0 0 231 283 1 2
TICAM1 NFATC2 0 0 61 157 1 1
TICAM1 PIAS4 270 0 109 364 1 1
TICAM1 RAC2 0 0 48 153 1 1
TICAM1 TBK1 870 600 898 995 1 2
TICAM1 TICAM2 865 800 971 981 1 1
TICAM1 FOXP3 0 0 204 218 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0060090 Molecular Function molecular adaptor activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0019901 Molecular Function protein kinase binding enables IBA
GO:0019901 Molecular Function protein kinase binding enables IPI
GO:0042100 Biological Process B cell proliferation involved_in IEA
GO:0035666 Biological Process TRIF-dependent toll-like receptor signaling pathway involved_in IBA
GO:0035666 Biological Process TRIF-dependent toll-like receptor signaling pathway involved_in IMP
GO:0035666 Biological Process TRIF-dependent toll-like receptor signaling pathway involved_in ISS
GO:0097190 Biological Process apoptotic signaling pathway involved_in IEA
GO:0007249 Biological Process canonical NF-kappaB signal transduction involved_in IEA
GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in ISS
GO:0140052 Biological Process cellular response to oxidised low-density lipoprotein particle stimulus involved_in ISS
GO:0051607 Biological Process defense response to virus involved_in IEA
GO:0006954 Biological Process inflammatory response involved_in IEA
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0031663 Biological Process lipopolysaccharide-mediated signaling pathway involved_in IBA
GO:0002281 Biological Process macrophage activation involved in immune response involved_in IEA
GO:0006809 Biological Process nitric oxide biosynthetic process involved_in IEA
GO:0030890 Biological Process positive regulation of B cell proliferation involved_in IEA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IBA
GO:0010508 Biological Process positive regulation of autophagy involved_in ISS
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in HMP
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IBA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IMP
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in ISS
GO:0032722 Biological Process positive regulation of chemokine production involved_in IEA
GO:1900017 Biological Process positive regulation of cytokine production involved in inflammatory response involved_in IBA
GO:1900017 Biological Process positive regulation of cytokine production involved in inflammatory response involved_in ISS
GO:0010628 Biological Process positive regulation of gene expression involved_in ISS
GO:0032728 Biological Process positive regulation of interferon-beta production involved_in IEA
GO:0032755 Biological Process positive regulation of interleukin-6 production involved_in IEA
GO:0060907 Biological Process positive regulation of macrophage cytokine production involved_in IEA
GO:0002735 Biological Process positive regulation of myeloid dendritic cell cytokine production involved_in IBA
GO:0002735 Biological Process positive regulation of myeloid dendritic cell cytokine production involved_in ISS
GO:0032816 Biological Process positive regulation of natural killer cell activation involved_in IBA
GO:0045429 Biological Process positive regulation of nitric oxide biosynthetic process involved_in IEA
GO:0031398 Biological Process positive regulation of protein ubiquitination involved_in IEA
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IEA
GO:0032481 Biological Process positive regulation of type I interferon production involved_in IDA
GO:0043254 Biological Process regulation of protein-containing complex assembly involved_in IEA
GO:0043330 Biological Process response to exogenous dsRNA involved_in IBA
GO:0043330 Biological Process response to exogenous dsRNA acts_upstream_of_or_within IMP
GO:0043330 Biological Process response to exogenous dsRNA involved_in ISS
GO:0034138 Biological Process toll-like receptor 3 signaling pathway involved_in IDA
GO:0002224 Biological Process toll-like receptor signaling pathway involved_in IDA
GO:0005776 Cellular Component autophagosome located_in IEA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005769 Cellular Component early endosome is_active_in IDA
GO:0005768 Cellular Component endosome is_active_in IDA
GO:0010008 Cellular Component endosome membrane is_active_in IDA
GO:0010008 Cellular Component endosome membrane located_in TAS
GO:0005739 Cellular Component mitochondrion located_in ISS
GO:0097342 Cellular Component ripoptosome part_of IDA
Pathways
Name DB ID
Apoptosis Reactome R-HSA-109581
Caspase activation via Death Receptors in the presence of ligand Reactome R-HSA-140534
ZBP1(DAI) mediated induction of type I IFNs Reactome R-HSA-1606322
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome R-HSA-168181
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
TICAM1, RIP1-mediated IKK complex recruitment Reactome R-HSA-168927
RIP-mediated NFkB activation via ZBP1 Reactome R-HSA-1810476
Cytosolic sensors of pathogen-associated DNA Reactome R-HSA-1834949
TRIF-mediated programmed cell death Reactome R-HSA-2562578
Diseases of Immune System Reactome R-HSA-5260271
Caspase activation via extrinsic apoptotic signalling pathway Reactome R-HSA-5357769
Programmed Cell Death Reactome R-HSA-5357801
Diseases associated with the TLR signaling cascade Reactome R-HSA-5602358
TICAM1 deficiency - HSE Reactome R-HSA-5602566
TRAF3 deficiency - HSE Reactome R-HSA-5602571
TLR3-mediated TICAM1-dependent programmed cell death Reactome R-HSA-9013957
TICAM1-dependent activation of IRF3/IRF7 Reactome R-HSA-9013973
TICAM1,TRAF6-dependent induction of TAK1 complex Reactome R-HSA-9014325
Activation of IRF3, IRF7 mediated by TBK1, IKBKE Reactome R-HSA-936964
IKK complex recruitment mediated by RIP1 Reactome R-HSA-937041
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
TRAF6-mediated induction of TAK1 complex within TLR4 complex Reactome R-HSA-937072
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome R-HSA-975138
MyD88 dependent cascade initiated on endosome Reactome R-HSA-975155
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Reactome R-HSA-975163
TLR4 signaling and tolerance (WP3851) WikiPathways WP3851_r121712
Hepatitis B infection (WP4666) WikiPathways WP4666_r123495
Toll-like receptor signaling related to MyD88 (WP3858) WikiPathways WP3858_r117850
SARS coronavirus and innate immunity (WP4912) WikiPathways WP4912_r124650
Acute viral myocarditis (WP4298) WikiPathways WP4298_r123508
Toll-like receptor signaling pathway (WP75) WikiPathways WP75_r119233
Mitochondrial immune response to SARS-CoV-2 (WP5038) WikiPathways WP5038_r124641
Nanoparticle triggered regulated necrosis (WP2513) WikiPathways WP2513_r119820
Host-pathogen interaction of human coronaviruses - interferon induction (WP4880) WikiPathways WP4880_r124638
Fibrin complement receptor 3 signaling pathway (WP4136) WikiPathways WP4136_r120387
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001385679 1 mRNA transcript variant 3 NC_000019 Reference
NM_001385678 1 mRNA transcript variant 2 NC_000019 Reference
NM_001385680 1 mRNA transcript variant 4 NC_000019 Reference
NM_182919 4 mRNA transcript variant 1 NC_000019 Reference