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CYP2E1

cytochrome P450 family 2 subfamily E member 1
General Information
Name cytochrome P450 family 2 subfamily E member 1
Alias
  • cytochrome P450 2E1
  • 4-nitrophenol 2-hydroxylase
  • CYPIIE1
  • cytochrome P450, family 2, subfamily E, polypeptide 1
  • cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
  • cytochrome P450-J
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • xenobiotic monooxygenase
Gene_family Cytochrome P450 family 2
organism Homo sapiens
entrez_id 1571
location 10q26.3
transcript_count 1
exon_count 9
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
    Stringdb Cytochrome P450 2E1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms; Cytochrome P450 family 2
    nextProt A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
CYP2E1 BioGRID POLR3E GeneID BioGRID Affinity Capture-MS
CYP2E1 BioGRID RMDN1 GeneID BioGRID Affinity Capture-MS
CYP2E1 BioGRID DDX39A GeneID BioGRID Affinity Capture-RNA
CYP2E1 BioGRID CYP2C2 GeneID BioGRID PCA
CYP2E1 BioGRID POR GeneID BioGRID PCA; Reconstituted Complex
CYP2E1 BioGRID ABCA5 GeneID BioGRID Two-hybrid
CYP2E1 BioGRID LAMC3 GeneID BioGRID Two-hybrid
CYP2E1 BioGRID NMI GeneID BioGRID Two-hybrid
CYP2E1 BioGRID PTN GeneID BioGRID Two-hybrid
CYP2E1 BioGRID MAFG GeneID BioGRID Two-hybrid
CYP2E1 BioGRID GATM GeneID BioGRID Two-hybrid
CYP2E1 BioGRID ECHS1 GeneID BioGRID Two-hybrid
CYP2E1 BioGRID CYB5A GeneID BioGRID Reconstituted Complex
CYP2E1 BioGRID AGXT2 GeneID BioGRID Two-hybrid
CYP2E1 BioGRID RPL13A GeneID BioGRID Two-hybrid
CYP2E1 BioGRID CLU GeneID BioGRID Two-hybrid
CYP2E1 BioGRID STUB1 GeneID BioGRID Biochemical Activity
CYP2E1 BioGRID AMFR GeneID BioGRID Biochemical Activity
CYP2E1 BioGRID FANCG GeneID BioGRID Affinity Capture-Western; Two-hybrid
CYP2E1 Protein POR GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
CYP2E1 DGAT2 0 0 294 310 1 1
CYP2E1 CRY1 0 0 154 161 1 1
CYP2E1 MB 0 0 156 156 1 2
CYP2E1 SLC2A4 0 0 181 222 1 1
CYP2E1 PLB1 0 650 55 661 1 1
CYP2E1 FOXO3 0 0 181 222 1 2
CYP2E1 GATA5 0 0 304 325 1 1
CYP2E1 APOE 0 0 232 248 1 2
CYP2E1 TM6SF2 0 0 261 280 1 1
CYP2E1 SCD 0 0 336 386 1 1
CYP2E1 HP 0 0 184 221 1 1
CYP2E1 AFMID 0 0 112 171 1 1
CYP2E1 SRC 0 0 167 186 1 2
CYP2E1 F2 0 0 216 265 1 1
CYP2E1 CYP11B1 0 0 141 305 1 1
CYP2E1 APOC1 0 0 136 253 1 1
CYP2E1 GPX6 0 0 55 404 1 1
CYP2E1 TIMM44 0 0 103 225 1 1
CYP2E1 SUOX 0 0 135 172 1 1
CYP2E1 WBSCR22 0 0 0 156 1 1
CYP2E1 PSMB5 0 0 72 194 1 1
CYP2E1 COQ6 0 0 0 240 1 1
CYP2E1 MVD 0 0 81 178 1 1
CYP2E1 UGT2B4 0 650 342 804 1 1
CYP2E1 COMT 0 0 390 416 1 1
CYP2E1 UGT2B7 0 650 561 869 1 1
CYP2E1 UGT2B15 0 650 391 819 1 1
CYP2E1 A2M 0 0 120 229 1 1
CYP2E1 EIF2AK3 0 0 216 216 1 2
CYP2E1 HNF4A 0 0 464 505 1 1
CYP2E1 JMJD7-PLA2G4B 0 650 0 650 1 1
CYP2E1 KLHL7 0 0 0 158 1 1
CYP2E1 ACLY 0 0 203 218 1 1
CYP2E1 FMO2 0 0 54 328 1 1
CYP2E1 NAT1 0 900 537 955 1 1
CYP2E1 HMOX1 0 0 602 621 1 2
CYP2E1 SLC17A7 0 0 0 173 1 1
CYP2E1 MGST1 0 650 246 733 1 1
CYP2E1 CYP4V2 0 0 249 339 1 1
CYP2E1 FGA 0 0 193 270 1 1
CYP2E1 DHRS9 0 0 134 159 1 1
CYP2E1 ADIPOR2 0 0 189 279 1 1
CYP2E1 TOMM20 0 0 137 196 1 2
CYP2E1 CYP2C9 0 900 876 910 1 1
CYP2E1 A1BG 0 0 0 208 1 1
CYP2E1 UGT2B11 0 650 134 743 1 1
CYP2E1 H6PD 0 0 109 189 1 1
CYP2E1 GLUL 0 0 394 407 1 1
CYP2E1 MSX2 0 0 0 400 1 1
CYP2E1 VDAC1 0 0 166 165 1 2
CYP2E1 KRT19 0 0 216 221 1 1
CYP2E1 ECI2 0 0 0 230 1 1
CYP2E1 TGFB1 0 0 231 279 1 2
CYP2E1 RIPK3 0 0 160 173 1 2
CYP2E1 HSD3B7 0 0 89 226 1 1
CYP2E1 GSTA3 0 650 298 769 1 1
CYP2E1 ACSM6 0 0 150 167 1 1
CYP2E1 HSD17B2 0 0 113 201 1 1
CYP2E1 GSTZ1 0 0 364 414 1 1
CYP2E1 CYP2D6 0 0 878 215 1 1
CYP2E1 GPC3 0 0 128 210 1 1
CYP2E1 GSTM4 0 650 241 835 1 1
CYP2E1 PPARG 0 0 460 481 1 2
CYP2E1 AKT1 0 0 390 410 1 2
CYP2E1 CPT1A 0 0 304 319 1 1
CYP2E1 BHMT 0 0 343 367 1 1
CYP2E1 CES5A 0 0 60 191 1 1
CYP2E1 ECHS1 111 0 161 289 1 1
CYP2E1 DRGX 0 0 0 396 1 1
CYP2E1 UGT1A1 0 650 638 886 1 1
CYP2E1 ST8SIA4 0 0 193 193 1 1
CYP2E1 GGT1 0 0 402 429 1 1
CYP2E1 LY96 0 0 150 181 1 1
CYP2E1 CYP8B1 0 0 393 220 1 1
CYP2E1 FAS 0 0 166 165 1 2
CYP2E1 ACOX2 0 0 113 185 1 1
CYP2E1 VCAM1 0 0 150 184 1 1
CYP2E1 ALKBH8 0 0 0 246 1 1
CYP2E1 HSPH1 0 0 0 153 1 1
CYP2E1 CD4 0 0 229 228 1 2
CYP2E1 CYP21A2 0 0 325 333 1 1
CYP2E1 ATF4 0 0 155 154 1 2
CYP2E1 CALR3 0 0 0 160 1 1
CYP2E1 ACACB 0 0 170 194 1 1
CYP2E1 SLC10A1 0 0 508 531 1 1
CYP2E1 DUOX1 0 0 246 321 1 1
CYP2E1 SLCO1A2 0 0 535 545 1 1
CYP2E1 COL1A2 0 0 170 169 1 1
CYP2E1 ATF6 0 0 260 272 1 2
CYP2E1 SLC26A6 0 0 0 151 1 1
CYP2E1 GSTM1 0 650 769 918 1 1
CYP2E1 IKBKB 0 0 138 151 1 2
CYP2E1 FMOD 0 0 88 254 1 1
CYP2E1 NOX4 0 0 323 426 1 2
CYP2E1 CYP2A7 0 0 709 161 1 1
CYP2E1 SLC7A2 0 0 70 185 1 1
CYP2E1 TCERG1L 0 0 107 173 1 1
CYP2E1 ADH4 0 900 612 960 1 1
CYP2E1 SEPP1 0 0 57 155 1 1
CYP2E1 GPT 0 0 739 747 1 1
CYP2E1 SLC12A6 0 0 46 164 1 1
CYP2E1 PINK1 0 0 139 165 1 2
CYP2E1 RDH16 0 0 125 177 1 1
CYP2E1 C1QTNF1 0 0 54 158 1 1
CYP2E1 HSP90AB1 0 0 50 313 1 2
CYP2E1 GATM 111 0 70 230 1 1
CYP2E1 ALAS1 0 0 134 181 1 1
CYP2E1 KIAA1456 0 0 0 156 1 1
CYP2E1 FGG 0 0 144 313 1 1
CYP2E1 TYMS 0 0 155 167 1 1
CYP2E1 UGT1A9 0 650 469 832 1 1
CYP2E1 KRT18 0 0 335 354 1 1
CYP2E1 LPA 0 0 0 231 1 1
CYP2E1 FDX1 0 0 362 408 1 1
CYP2E1 HYKK 0 0 123 152 1 1
CYP2E1 GSTA2 0 650 402 803 1 1
CYP2E1 HAO1 0 0 57 167 1 1
CYP2E1 AIFM1 0 0 0 162 1 1
CYP2E1 CYP2J2 0 900 652 912 1 1
CYP2E1 NR5A2 0 0 127 221 1 1
CYP2E1 NR1I2 0 0 664 703 1 1
CYP2E1 UGT1A6 0 650 653 891 1 1
CYP2E1 TLR9 0 0 164 163 1 2
CYP2E1 ENSG00000274276 0 0 150 219 1 1
CYP2E1 PRDX3 0 0 173 188 1 1
CYP2E1 GYS2 0 0 161 211 1 1
CYP2E1 SLC28A3 0 0 75 173 1 1
CYP2E1 TH 0 0 143 175 1 2
CYP2E1 AGO3 0 0 70 201 1 1
CYP2E1 CYP2C19 0 900 870 907 1 1
CYP2E1 CYB5R3 0 0 184 202 1 1
CYP2E1 FAM173B 0 0 45 159 1 1
CYP2E1 INMT 0 0 125 191 1 1
CYP2E1 ATP12A 0 0 251 263 1 1
CYP2E1 AXIN2 0 0 161 167 1 1
CYP2E1 GCG 0 0 240 239 1 1
CYP2E1 GSTP1 0 650 681 887 1 1
CYP2E1 APOC3 0 0 160 251 1 1
CYP2E1 CYP2A6 0 900 878 914 1 1
CYP2E1 THRSP 0 0 103 151 1 1
CYP2E1 SLC17A8 0 0 0 153 1 1
CYP2E1 PZP 0 0 0 160 1 1
CYP2E1 CNR1 0 0 202 202 1 1
CYP2E1 GSTM5 0 650 245 734 1 1
CYP2E1 VKORC1 0 0 241 240 1 1
CYP2E1 RETN 0 0 137 186 1 1
CYP2E1 APOB 0 0 272 310 1 2
CYP2E1 PLA2G3 0 650 0 650 1 1
CYP2E1 ACSBG2 0 0 0 152 1 1
CYP2E1 ANAPC2 0 0 0 157 1 1
CYP2E1 IGF1 0 0 211 228 1 2
CYP2E1 ITIH4 0 0 123 170 1 1
CYP2E1 ALDH9A1 0 0 149 192 1 1
CYP2E1 ARNTL 0 0 181 181 1 1
CYP2E1 FABP1 0 0 284 322 1 1
CYP2E1 SLC38A3 0 0 95 189 1 1
CYP2E1 SLC19A1 0 0 83 180 1 1
CYP2E1 TNF 0 0 556 608 1 2
CYP2E1 MSX1 0 0 0 261 1 1
CYP2E1 PLA2G2A 0 650 133 683 1 1
CYP2E1 XDH 0 0 184 329 1 1
CYP2E1 UGT1A4 0 650 465 831 1 1
CYP2E1 FAXDC2 0 0 0 199 1 1
CYP2E1 PLA2G12A 0 650 51 653 1 1
CYP2E1 BDNF 0 0 144 177 1 2
CYP2E1 PDLIM5 0 0 0 151 1 1
CYP2E1 IP6K1 0 0 53 163 1 1
CYP2E1 HDC 0 0 49 315 1 1
CYP2E1 SLC35F5 0 0 90 241 1 1
CYP2E1 IP6K3 0 0 67 175 1 1
CYP2E1 ABHD5 0 0 0 151 1 1
CYP2E1 VDR 0 0 204 261 1 2
CYP2E1 CES1 0 900 235 930 1 1
CYP2E1 SLC22A7 0 0 244 358 1 1
CYP2E1 PLA2G4D 0 650 0 650 1 1
CYP2E1 MUTYH 0 0 416 416 1 1
CYP2E1 ACADM 0 0 212 253 1 1
CYP2E1 PON3 0 0 94 191 1 1
CYP2E1 NRIP1 0 0 88 252 1 1
CYP2E1 UGT1A10 0 650 293 777 1 1
CYP2E1 ALDH7A1 0 0 123 158 1 1
CYP2E1 GLS2 0 0 113 179 1 1
CYP2E1 PAH 0 0 433 463 1 1
CYP2E1 CBSL 0 0 150 219 1 1
CYP2E1 SLC7A11 0 0 108 193 1 2
CYP2E1 MT2A 0 0 176 192 1 1
CYP2E1 LDLR 0 0 166 165 1 2
CYP2E1 ADH6 0 900 358 936 1 1
CYP2E1 SLCO1B1 0 0 500 513 1 1
CYP2E1 CYP4F22 0 0 134 421 1 1
CYP2E1 SLC39A13 0 0 47 193 1 1
CYP2E1 FAH 0 0 229 258 1 1
CYP2E1 SLC27A1 0 0 112 187 1 1
CYP2E1 AHCY 0 0 150 189 1 1
CYP2E1 HPRT1 0 0 248 248 1 1
CYP2E1 FDFT1 0 0 90 286 1 1
CYP2E1 UXS1 0 0 0 171 1 1
CYP2E1 AKR1C1 0 900 234 933 1 1
CYP2E1 NR1D1 0 0 155 160 1 2
CYP2E1 FOXA2 0 0 165 196 1 1
CYP2E1 SLC7A13 0 0 0 175 1 1
CYP2E1 CANX 0 0 123 158 1 2
CYP2E1 TXN 0 0 292 321 1 1
CYP2E1 ALDH5A1 0 0 167 200 1 1
CYP2E1 OPRM1 0 0 203 203 1 1
CYP2E1 ABCG5 0 0 146 197 1 1
CYP2E1 SLC17A5 0 0 0 155 1 1
CYP2E1 FADS2 0 0 134 172 1 1
CYP2E1 HPD 0 0 94 256 1 1
CYP2E1 ENSG00000264813 0 0 203 215 1 1
CYP2E1 AOX1 0 0 456 467 1 1
CYP2E1 CWF19L2 0 0 0 158 1 1
CYP2E1 HGF 0 0 252 283 1 2
CYP2E1 SFTPD 0 0 81 179 1 1
CYP2E1 OR1J1 0 0 143 294 1 1
CYP2E1 PLA2G12B 0 650 0 658 1 1
CYP2E1 SPINK1 0 0 450 463 1 1
CYP2E1 CAT 0 0 685 713 1 2
CYP2E1 GSTT2B 0 650 325 764 1 1
CYP2E1 SLC7A8 0 0 81 217 1 1
CYP2E1 PRRX2 0 0 0 170 1 1
CYP2E1 USHBP1 0 0 90 246 1 1
CYP2E1 SLCO2B1 0 0 269 285 1 1
CYP2E1 RPS6KB1 0 0 119 154 1 2
CYP2E1 SERPINE1 0 0 181 181 1 1
CYP2E1 AHR 0 0 556 578 1 2
CYP2E1 SRP68 0 0 0 159 1 1
CYP2E1 LECT2 0 0 139 195 1 1
CYP2E1 SPAM1 0 0 43 213 1 1
CYP2E1 DAGLB 0 0 166 165 1 1
CYP2E1 NOX5 0 0 107 173 1 1
CYP2E1 CYP24A1 0 0 261 362 1 1
CYP2E1 GSTA1 0 650 459 821 1 1
CYP2E1 HMGCR 0 0 229 294 1 1
CYP2E1 AOC2 0 0 184 217 1 1
CYP2E1 FDXR 0 0 230 246 1 1
CYP2E1 LOX 0 0 218 218 1 2
CYP2E1 IRS1 0 0 268 269 1 2
CYP2E1 PRMT8 0 0 0 156 1 1
CYP2E1 ABCG2 0 0 390 418 1 1
CYP2E1 NCF1 0 0 323 323 1 1
CYP2E1 STON2 0 0 0 167 1 1
CYP2E1 MTHFR 0 0 406 428 1 1
CYP2E1 CYP20A1 0 0 231 288 1 1
CYP2E1 ADH5 0 900 556 953 1 1
CYP2E1 PRPF19 0 0 0 181 1 1
CYP2E1 SLC35A2 0 0 602 611 1 1
CYP2E1 CAPN11 0 0 134 179 1 1
CYP2E1 ENSG00000273171 0 0 0 182 1 1
CYP2E1 SREBF2 0 0 244 255 1 1
CYP2E1 AGXT 0 0 81 307 1 1
CYP2E1 CCND1 0 0 320 319 1 2
CYP2E1 ALDH2 0 900 739 974 1 2
CYP2E1 CD36 0 0 147 187 1 2
CYP2E1 JUND 0 0 73 203 1 1
CYP2E1 DPYD 0 0 283 300 1 1
CYP2E1 ACTA2 0 0 81 279 1 1
CYP2E1 NOS3 0 0 227 264 1 2
CYP2E1 NR5A1 0 0 53 155 1 1
CYP2E1 MTRR 0 0 134 175 1 1
CYP2E1 MUC6 0 0 488 487 1 1
CYP2E1 SDR42E2 0 0 0 171 1 1
CYP2E1 ATM 0 0 122 155 1 2
CYP2E1 HSD3B2 0 900 107 920 1 1
CYP2E1 PRKAG3 0 0 0 159 1 1
CYP2E1 SERPINC1 0 0 103 301 1 1
CYP2E1 SULT2B1 0 900 141 916 1 1
CYP2E1 PON2 0 0 202 202 1 1
CYP2E1 GOT2 0 0 261 265 1 1
CYP2E1 ALDH1B1 0 0 341 381 1 1
CYP2E1 HRG 0 0 0 155 1 1
CYP2E1 ENSG00000270386 0 0 223 371 1 1
CYP2E1 G6PD 0 0 413 431 1 1
CYP2E1 GDF15 0 0 54 155 1 1
CYP2E1 CCNL1 0 0 0 180 1 1
CYP2E1 NR1H4 0 0 460 494 1 1
CYP2E1 TJP1 0 0 193 193 1 1
CYP2E1 RXRG 0 0 97 170 1 1
CYP2E1 ATG7 0 0 193 193 1 2
CYP2E1 COL1A1 0 0 209 209 1 2
CYP2E1 CYP4F8 0 0 242 369 1 1
CYP2E1 GSTA5 0 650 208 739 1 1
CYP2E1 IL10 0 0 324 323 1 2
CYP2E1 FGFR4 0 0 128 172 1 1
CYP2E1 UGT1A7 0 650 365 800 1 1
CYP2E1 UGT1A5 0 650 325 787 1 1
CYP2E1 PTEN 0 0 205 209 1 2
CYP2E1 ACSM1 0 0 96 159 1 1
CYP2E1 GC 0 0 90 221 1 1
CYP2E1 VEGFA 0 0 234 234 1 2
CYP2E1 TXN2 0 0 163 181 1 1
CYP2E1 ACSL4 0 0 82 159 1 1
CYP2E1 AGO1 0 0 51 173 1 1
CYP2E1 FMO3 0 0 390 593 1 1
CYP2E1 SLC22A2 0 0 182 281 1 1
CYP2E1 PLA2G5 0 650 0 650 1 1
CYP2E1 NFE2L1 0 0 0 209 1 1
CYP2E1 FGB 0 0 158 193 1 1
CYP2E1 LEP 0 0 381 402 1 1
CYP2E1 NFKBIA 0 0 243 255 1 2
CYP2E1 HFE 0 0 134 200 1 1
CYP2E1 LDHA 0 0 89 153 1 2
CYP2E1 FAM173A 0 0 0 156 1 1
CYP2E1 SLC27A2 0 0 181 288 1 1
CYP2E1 SREBF1 0 0 561 570 1 1
CYP2E1 ALKBH7 0 0 0 213 1 1
CYP2E1 LPXN 0 0 0 152 1 1
CYP2E1 MAPK14 0 0 148 292 1 2
CYP2E1 SIRT1 0 0 391 392 1 2
CYP2E1 PLIN2 0 0 275 290 1 2
CYP2E1 MCL1 0 0 134 151 1 2
CYP2E1 ACADS 0 0 125 177 1 1
CYP2E1 KHK 0 0 166 186 1 1
CYP2E1 NOX1 0 0 261 334 1 1
CYP2E1 CTSB 0 0 151 173 1 2
CYP2E1 ACOX1 0 0 360 426 1 1
CYP2E1 SULT1E1 0 0 294 323 1 1
CYP2E1 WLS 0 0 112 167 1 1
CYP2E1 NAGS 0 0 134 207 1 1
CYP2E1 ESR1 0 0 294 332 1 2
CYP2E1 HMGB1 0 0 264 264 1 2
CYP2E1 DUOX2 0 0 242 317 1 1
CYP2E1 MAP3K5 0 0 322 326 1 1
CYP2E1 PDK4 0 0 167 255 1 1
CYP2E1 SMAD7 0 0 141 155 1 1
CYP2E1 ITGB3 0 0 292 292 1 1
CYP2E1 SLC17A2 0 0 0 171 1 1
CYP2E1 ATG5 0 0 181 181 1 2
CYP2E1 SLC22A5 0 0 171 271 1 1
CYP2E1 SLC6A3 0 0 210 242 1 1
CYP2E1 EPHX1 0 900 767 978 1 1
CYP2E1 IRF1 0 0 325 325 1 2
CYP2E1 SRD5A2 0 0 113 230 1 1
CYP2E1 ATP4A 0 0 249 261 1 1
CYP2E1 PRKAG2 0 0 0 167 1 1
CYP2E1 XBP1 0 0 254 259 1 2
CYP2E1 TPPP 0 0 64 150 1 1
CYP2E1 IVD 0 0 0 168 1 1
CYP2E1 NCF2 0 0 210 210 1 1
CYP2E1 ALKBH5 0 0 0 175 1 1
CYP2E1 CYB5D2 0 0 68 167 1 1
CYP2E1 AADAC 0 0 179 276 1 1
CYP2E1 HMOX2 0 0 153 194 1 1
CYP2E1 CYP2C8 0 900 841 912 1 1
CYP2E1 LSS 0 0 74 299 1 1
CYP2E1 CYP11B2 0 0 161 311 1 1
CYP2E1 GPX3 0 0 113 350 1 1
CYP2E1 CCNL2 0 0 0 161 1 1
CYP2E1 SOD3 0 0 170 210 1 1
CYP2E1 MMP13 0 0 150 179 1 2
CYP2E1 C3 0 0 232 295 1 2
CYP2E1 MT-CO1 0 0 123 152 1 1
CYP2E1 VTN 0 0 47 203 1 1
CYP2E1 FN1 0 0 203 203 1 2
CYP2E1 MT-CYB 0 0 430 448 1 1
CYP2E1 GPX1 0 0 407 480 1 1
CYP2E1 C14orf1 0 0 0 295 1 1
CYP2E1 ALKBH1 0 0 0 152 1 1
CYP2E1 GPX2 0 0 213 392 1 1
CYP2E1 PLA2G2F 0 650 58 662 1 1
CYP2E1 SOD2 0 0 392 396 1 2
CYP2E1 CYP2A13 0 900 739 909 1 1
CYP2E1 TAGLN2 0 0 0 213 1 1
CYP2E1 FOXO1 0 0 194 206 1 2
CYP2E1 FANCG 293 0 980 985 1 1
CYP2E1 KRAS 0 0 170 200 1 2
CYP2E1 KDM2B 0 0 0 154 1 1
CYP2E1 PRMT9 0 0 0 156 1 1
CYP2E1 AKR1A1 0 0 95 154 1 1
CYP2E1 HSPA5 0 0 293 308 1 2
CYP2E1 CCBL1 0 0 82 334 1 1
CYP2E1 NAA30 0 0 64 161 1 1
CYP2E1 METTL7B 0 0 75 219 1 1
CYP2E1 RXRA 0 0 171 324 1 1
CYP2E1 PON1 0 0 324 333 1 1
CYP2E1 CLDN2 0 0 109 153 1 1
CYP2E1 SLCO4A1 0 0 159 158 1 1
CYP2E1 FASLG 0 0 229 228 1 1
CYP2E1 MAT1A 0 0 260 296 1 1
CYP2E1 NAT2 0 900 701 971 1 1
CYP2E1 FOS 0 0 216 216 1 2
CYP2E1 VBP1 0 0 60 228 1 1
CYP2E1 GNMT 0 0 184 242 1 1
CYP2E1 CYP3A43 0 0 414 396 1 1
CYP2E1 LPIN1 0 0 261 261 1 2
CYP2E1 SIGMAR1 0 0 52 283 1 1
CYP2E1 ACOX3 0 0 113 170 1 1
CYP2E1 OTC 0 0 161 197 1 1
CYP2E1 SLC26A10 0 0 0 151 1 1
CYP2E1 ACADVL 0 0 127 180 1 1
CYP2E1 GSTM2 0 650 422 815 1 1
CYP2E1 SRD5A1 0 0 103 159 1 1
CYP2E1 CYP27C1 0 0 57 286 1 1
CYP2E1 MET 0 0 134 170 1 2
CYP2E1 SLC22A9 0 0 134 233 1 1
CYP2E1 TLR2 0 0 181 181 1 2
CYP2E1 ACADL 0 0 157 258 1 1
CYP2E1 PLA2G4F 0 650 0 650 1 1
CYP2E1 ALDH1A1 0 0 335 510 1 1
CYP2E1 ABCC1 0 0 260 285 1 1
CYP2E1 IL2 0 0 165 165 1 1
CYP2E1 FMO5 0 0 137 438 1 1
CYP2E1 FBXL19 0 0 0 157 1 1
CYP2E1 ABCB1 0 0 457 474 1 2
CYP2E1 CYP11A1 0 0 261 354 1 1
CYP2E1 CYB5R4 0 0 0 164 1 1
CYP2E1 ADHFE1 0 0 142 204 1 1
CYP2E1 BECN1 0 0 229 228 1 2
CYP2E1 MAOB 0 0 267 284 1 1
CYP2E1 UGT2A1 0 0 206 357 1 1
CYP2E1 METTL11B 0 0 90 171 1 1
CYP2E1 CYBB 0 0 324 391 1 2
CYP2E1 SULT1A3 0 0 210 275 1 1
CYP2E1 ABHD4 0 0 0 169 1 1
CYP2E1 SULT1C2 0 0 193 246 1 1
CYP2E1 AFM 0 0 49 218 1 1
CYP2E1 STS 0 900 66 902 1 1
CYP2E1 TNFRSF10B 0 0 137 154 1 2
CYP2E1 PRMT2 0 0 0 156 1 1
CYP2E1 ACE 0 0 212 224 1 1
CYP2E1 CYP46A1 0 0 260 340 1 1
CYP2E1 HSPA4L 0 0 0 153 1 1
CYP2E1 ALOX5 0 900 208 917 1 1
CYP2E1 PTGS2 0 900 457 945 1 2
CYP2E1 CYP26A1 0 0 341 370 1 1
CYP2E1 CASP3 0 0 518 531 1 2
CYP2E1 RPSA 0 0 0 190 1 1
CYP2E1 NQO1 0 0 608 608 1 2
CYP2E1 HADH 0 0 124 158 1 1
CYP2E1 LIPC 0 0 138 190 1 1
CYP2E1 AFP 0 0 390 420 1 2
CYP2E1 ENPP1 0 0 105 210 1 1
CYP2E1 RGN 0 0 233 282 1 1
CYP2E1 PRMT7 0 0 0 156 1 1
CYP2E1 DBI 0 0 134 194 1 1
CYP2E1 NLRP3 0 0 230 229 1 2
CYP2E1 PLA2G6 0 650 46 665 1 1
CYP2E1 ACSM3 0 0 108 221 1 1
CYP2E1 CXCL1 0 0 143 161 1 2
CYP2E1 ESRRG 0 0 160 188 1 1
CYP2E1 APCS 0 0 74 170 1 1
CYP2E1 KIAA1524 0 0 0 213 1 1
CYP2E1 CYP26B1 0 0 217 310 1 1
CYP2E1 CYP26C1 0 0 134 282 1 1
CYP2E1 ABCB4 0 0 284 312 1 1
CYP2E1 RIPK1 0 0 156 169 1 2
CYP2E1 AHSG 0 0 84 320 1 1
CYP2E1 SLCO1C1 0 0 146 224 1 1
CYP2E1 CEBPB 0 0 253 264 1 2
CYP2E1 DHFR 0 0 125 159 1 1
CYP2E1 CDO1 0 0 0 157 1 1
CYP2E1 TXNRD1 0 0 172 204 1 1
CYP2E1 PLA2G2C 0 650 0 651 1 1
CYP2E1 ACOT1 0 0 162 267 1 1
CYP2E1 FBP1 0 0 75 159 1 1
CYP2E1 PLA2G4B 0 650 0 650 1 1
CYP2E1 HPX 0 0 67 264 1 1
CYP2E1 PNPLA3 0 0 423 439 1 1
CYP2E1 GPX8 0 0 0 428 1 1
CYP2E1 TTR 0 0 240 279 1 1
CYP2E1 GSK3B 0 0 181 211 1 2
CYP2E1 KRT7 0 0 137 174 1 1
CYP2E1 CDKN2A 0 0 181 193 1 2
CYP2E1 ERCC1 0 0 211 222 1 1
CYP2E1 GUSB 0 0 144 163 1 1
CYP2E1 SAA1 0 0 135 154 1 1
CYP2E1 ACOT2 0 0 61 179 1 1
CYP2E1 CISD1 0 0 112 152 1 1
CYP2E1 HSD11B1L 0 900 0 909 1 1
CYP2E1 C4A 0 0 97 172 1 1
CYP2E1 POTEF 0 0 95 157 1 1
CYP2E1 MTOR 0 0 172 171 1 2
CYP2E1 SUV420H1 0 0 0 158 1 1
CYP2E1 SULT1A2 0 0 320 376 1 1
CYP2E1 SULT1A1 0 0 635 665 1 1
CYP2E1 PRMT1 0 0 57 170 1 1
CYP2E1 PTGS1 0 900 227 922 1 1
CYP2E1 PDE8B 0 0 0 150 1 1
CYP2E1 ABCB11 0 0 405 428 1 1
CYP2E1 FMO1 0 0 308 685 1 1
CYP2E1 GGTLC3 0 0 163 200 1 1
CYP2E1 OCLN 0 0 207 224 1 1
CYP2E1 TNFRSF1A 0 0 206 206 1 1
CYP2E1 ALDH3B1 0 900 169 938 1 1
CYP2E1 CYP4A11 0 900 669 949 1 1
CYP2E1 CYP4A22 0 900 662 948 1 1
CYP2E1 ENDOG 0 0 281 293 1 1
CYP2E1 STAT1 0 0 166 165 1 2
CYP2E1 CPS1 0 0 213 329 1 1
CYP2E1 IL6 0 0 520 539 1 2
CYP2E1 CTRL 0 0 212 234 1 2
CYP2E1 EPHX2 0 0 261 378 1 1
CYP2E1 MPO 0 0 455 465 1 2
CYP2E1 PLIN1 0 0 162 181 1 1
CYP2E1 UCP2 0 0 283 282 1 2
CYP2E1 SLC17A3 0 0 45 203 1 1
CYP2E1 DPM2 0 0 57 313 1 1
CYP2E1 UGT8 0 0 150 207 1 1
CYP2E1 CXCL8 0 0 286 286 1 2
CYP2E1 SLC22A25 0 0 0 150 1 1
CYP2E1 SLC10A7 0 0 57 171 1 1
CYP2E1 IL1B 0 0 504 505 1 2
CYP2E1 NR1H3 0 0 217 318 1 1
CYP2E1 SP1 0 0 195 210 1 2
CYP2E1 HIF1A 0 0 283 282 1 2
CYP2E1 CYP27B1 0 0 505 432 1 1
CYP2E1 SLC22A8 0 0 310 364 1 1
CYP2E1 CYP4F2 0 900 469 941 1 1
CYP2E1 BAAT 0 0 246 265 1 1
CYP2E1 PRKAG1 0 0 0 167 1 1
CYP2E1 ACSL5 0 0 107 231 1 1
CYP2E1 CYP4B1 0 0 566 488 1 1
CYP2E1 PLA2G4A 0 650 157 692 1 1
CYP2E1 DHCR7 0 0 155 325 1 1
CYP2E1 LIPE 0 0 218 266 1 1
CYP2E1 EGR1 0 0 184 199 1 2
CYP2E1 RHBG 0 0 123 180 1 1
CYP2E1 CTNNB1 0 0 342 394 1 2
CYP2E1 SULT1B1 0 0 248 297 1 1
CYP2E1 SPRN 0 0 125 320 1 1
CYP2E1 HRAS 0 0 216 245 1 2
CYP2E1 AKR1C3 0 900 107 918 1 1
CYP2E1 CARM1 0 0 0 156 1 2
CYP2E1 AOC3 0 0 341 368 1 1
CYP2E1 BCL2L1 0 0 266 266 1 2
CYP2E1 GJB1 0 0 184 221 1 1
CYP2E1 KLF6 0 0 398 409 1 1
CYP2E1 XPA 0 0 155 154 1 1
CYP2E1 NFKB1 0 0 136 171 1 2
CYP2E1 SLC22A24 0 0 0 150 1 1
CYP2E1 GSTM3 0 650 504 823 1 1
CYP2E1 ALDH1A2 0 0 127 251 1 1
CYP2E1 NOS2 0 0 273 308 1 2
CYP2E1 APOA1 0 0 212 241 1 1
CYP2E1 HAMP 0 0 244 282 1 1
CYP2E1 GSTO1 0 650 244 732 1 1
CYP2E1 GAPDH 0 0 458 468 1 2
CYP2E1 PDE8A 0 0 0 150 1 1
CYP2E1 CYP1A1 0 900 872 927 1 2
CYP2E1 SLC22A13 0 0 45 160 1 1
CYP2E1 CYP1A2 0 900 914 930 1 1
CYP2E1 SMAD2 0 0 170 183 1 2
CYP2E1 PLGLB2 0 0 0 218 1 1
CYP2E1 TLR4 0 0 426 439 1 2
CYP2E1 TM7SF2 0 0 65 237 1 1
CYP2E1 CYP39A1 0 0 241 275 1 1
CYP2E1 CREB1 0 0 181 186 1 2
CYP2E1 AKR1B10 0 900 220 922 1 1
CYP2E1 HAL 0 0 0 161 1 1
CYP2E1 CCL5 0 0 150 168 1 2
CYP2E1 ETNPPL 0 0 112 166 1 1
CYP2E1 ACOT4 0 0 0 161 1 1
CYP2E1 HSD17B7 0 0 74 289 1 1
CYP2E1 HSD11B1 0 900 150 921 1 1
CYP2E1 IFNG 0 0 161 199 1 2
CYP2E1 NOX3 0 0 122 227 1 1
CYP2E1 APOA4 0 0 170 190 1 1
CYP2E1 SLC22A4 0 0 123 229 1 1
CYP2E1 CYP17A1 0 900 403 930 1 1
CYP2E1 UGT2A3 0 650 184 825 1 1
CYP2E1 HAVCR1 0 0 150 169 1 1
CYP2E1 GSTO2 0 650 183 720 1 1
CYP2E1 PRDX6 0 0 166 181 1 1
CYP2E1 LPCAT1 0 0 0 152 1 1
CYP2E1 EPHX4 0 0 95 155 1 1
CYP2E1 CYP4F3 0 900 492 941 1 1
CYP2E1 CA3 0 0 232 390 1 2
CYP2E1 SIRT2 0 0 148 155 1 2
CYP2E1 SC5D 0 0 54 234 1 1
CYP2E1 ALDH3B2 0 900 90 956 1 1
CYP2E1 MGMT 0 0 233 232 1 2
CYP2E1 HSPD1 0 0 134 168 1 1
CYP2E1 CCBL2 0 0 0 204 1 1
CYP2E1 SULT2A1 0 0 425 467 1 1
CYP2E1 CYP4X1 0 0 391 366 1 1
CYP2E1 FGF21 0 0 181 198 1 2
CYP2E1 PLA2G2E 0 650 91 668 1 1
CYP2E1 TEF 0 0 171 184 1 1
CYP2E1 ANXA5 0 0 202 202 1 2
CYP2E1 UGT3A2 0 0 113 280 1 1
CYP2E1 GGT2 0 0 151 189 1 1
CYP2E1 AGO4 0 0 66 211 1 1
CYP2E1 ACSL1 0 0 167 282 1 1
CYP2E1 XRCC3 0 0 247 246 1 1
CYP2E1 FHL2 0 0 142 178 1 1
CYP2E1 ALOX12 0 900 157 912 1 1
CYP2E1 TDO2 0 0 273 325 1 1
CYP2E1 UGT3A1 0 0 75 250 1 1
CYP2E1 HSD17B6 0 0 141 228 1 1
CYP2E1 ALOX12B 0 900 66 902 1 1
CYP2E1 POR 677 0 962 988 1 2
CYP2E1 PPIF 0 0 392 397 1 1
CYP2E1 CH25H 0 0 0 199 1 1
CYP2E1 OSM 0 0 181 195 1 1
CYP2E1 ASGR1 0 0 282 305 1 1
CYP2E1 CYB5A 270 0 940 960 1 1
CYP2E1 BRCA1 0 0 158 157 1 2
CYP2E1 ENSG00000254536 0 0 0 542 1 1
CYP2E1 ATCAY 0 0 0 202 1 1
CYP2E1 CYP3A7 0 0 633 459 1 1
CYP2E1 CARNS1 0 0 0 152 1 1
CYP2E1 NFE2L2 0 0 502 502 1 2
CYP2E1 AP1AR 0 0 455 455 1 1
CYP2E1 PPARGC1A 0 0 342 343 1 2
CYP2E1 PCK1 0 0 242 304 1 1
CYP2E1 IGF1R 0 0 75 168 1 2
CYP2E1 FA2H 0 0 108 363 1 1
CYP2E1 ABCC2 0 0 414 435 1 1
CYP2E1 NR0B2 0 0 398 431 1 1
CYP2E1 IL18 0 0 181 181 1 2
CYP2E1 CLOCK 0 0 210 213 1 2
CYP2E1 SLC6A4 0 0 241 245 1 1
CYP2E1 UGT2A2 0 650 231 772 1 1
CYP2E1 CYP51A1 0 0 420 311 1 1
CYP2E1 MYC 0 0 418 425 1 2
CYP2E1 DGAT1 0 0 175 205 1 2
CYP2E1 APEX1 0 0 174 173 1 1
CYP2E1 PPIG 0 0 875 876 1 1
CYP2E1 SDS 0 0 144 195 1 1
CYP2E1 ACACA 0 0 228 250 1 1
CYP2E1 RPSAP58 0 0 0 190 1 1
CYP2E1 LBR 0 0 0 217 1 1
CYP2E1 SERPINA5 0 0 171 207 1 1
CYP2E1 CES3 0 0 160 212 1 1
CYP2E1 NR1I3 0 900 601 961 1 1
CYP2E1 SLC22A10 0 0 0 192 1 1
CYP2E1 GSTCD 0 0 0 156 1 1
CYP2E1 APOH 0 0 122 247 1 1
CYP2E1 SLCO1B3 0 0 323 340 1 1
CYP2E1 CYP7B1 0 0 292 196 1 1
CYP2E1 SLC7A1 0 0 108 159 1 1
CYP2E1 TMBIM6 0 0 143 261 1 1
CYP2E1 P4HB 0 0 193 227 1 2
CYP2E1 GPX7 0 0 62 440 1 1
CYP2E1 G6PC 0 0 387 413 1 1
CYP2E1 SH3BP5 0 0 321 335 1 1
CYP2E1 SLC26A5 0 0 0 151 1 1
CYP2E1 PPARD 0 0 144 241 1 1
CYP2E1 SLCO1B3-SLCO1B7 0 0 323 340 1 1
CYP2E1 PLA2G4C 0 650 0 650 1 1
CYP2E1 CYBA 0 0 243 242 1 1
CYP2E1 SLC22A15 0 0 67 207 1 1
CYP2E1 UGT2B28 0 650 134 743 1 1
CYP2E1 GSTK1 0 0 244 260 1 1
CYP2E1 FMO6P 0 0 0 430 1 1
CYP2E1 TPMT 0 0 294 309 1 1
CYP2E1 ADH1C 0 900 654 972 1 1
CYP2E1 REG3G 0 0 143 156 1 1
CYP2E1 APAF1 0 0 143 172 1 2
CYP2E1 CPT2 0 0 181 214 1 1
CYP2E1 FANCC 0 0 181 181 1 1
CYP2E1 STAT3 0 0 297 297 1 2
CYP2E1 AGO2 0 0 61 182 1 2
CYP2E1 AKR1C4 0 0 171 274 1 1
CYP2E1 CES2 0 0 216 321 1 1
CYP2E1 SLC22A3 0 0 86 278 1 1
CYP2E1 PRKAR2A 0 0 66 161 1 1
CYP2E1 GCLM 0 0 373 395 1 1
CYP2E1 MGST2 0 650 0 650 1 1
CYP2E1 UGT2B10 0 650 277 785 1 1
CYP2E1 ERN1 0 0 283 294 1 2
CYP2E1 MYD88 0 0 192 192 1 2
CYP2E1 CFLAR 0 0 127 158 1 2
CYP2E1 EGFR 0 0 218 235 1 2
CYP2E1 DECR1 0 0 109 159 1 1
CYP2E1 SLC2A1 0 0 107 152 1 2
CYP2E1 BCO2 0 0 113 162 1 1
CYP2E1 HMGCS1 0 0 107 208 1 1
CYP2E1 SLC26A7 0 0 0 158 1 1
CYP2E1 NR1H2 0 0 93 208 1 1
CYP2E1 ERCC2 0 0 279 279 1 1
CYP2E1 ALOX15 0 900 150 911 1 1
CYP2E1 MAOA 0 0 193 212 1 1
CYP2E1 TGM2 0 0 73 166 1 2
CYP2E1 MDM2 0 0 167 167 1 2
CYP2E1 SLC26A4 0 0 0 151 1 1
CYP2E1 PSCA 0 0 627 627 1 1
CYP2E1 LCN2 0 0 155 154 1 1
CYP2E1 TP53 0 0 466 475 1 2
CYP2E1 PCDH12 0 0 45 161 1 1
CYP2E1 SULT1C4 0 0 122 158 1 1
CYP2E1 PNLIP 0 0 142 176 1 1
CYP2E1 SLMAP 0 0 0 158 1 1
CYP2E1 DDIT3 0 0 257 268 1 2
CYP2E1 SLC22A6 0 0 178 247 1 1
CYP2E1 CPB2 0 0 66 301 1 1
CYP2E1 ADH1A 0 900 562 966 1 1
CYP2E1 SLC2A2 0 0 171 230 1 1
CYP2E1 WBSCR27 0 0 0 156 1 1
CYP2E1 PLA2G4E 0 650 0 650 1 1
CYP2E1 ACSL6 0 0 45 177 1 1
CYP2E1 KDELC1 0 0 154 186 1 1
CYP2E1 CDH1 0 0 210 210 1 2
CYP2E1 RMDN1 229 0 0 228 1 1
CYP2E1 HSD17B11 0 0 94 220 1 1
CYP2E1 CBR3 0 900 84 907 1 1
CYP2E1 PLG 0 0 150 314 1 1
CYP2E1 MLXIPL 0 0 258 276 1 1
CYP2E1 C8B 0 0 107 179 1 1
CYP2E1 AKR1D1 0 0 174 200 1 1
CYP2E1 PLA2G16 0 650 0 650 1 1
CYP2E1 ASL 0 0 103 172 1 1
CYP2E1 TSTA3 0 0 0 171 1 1
CYP2E1 ALDH3A2 0 900 122 946 1 1
CYP2E1 C4B 0 0 87 162 1 1
CYP2E1 HMGCS2 0 0 161 256 1 1
CYP2E1 CP 0 0 131 201 1 1
CYP2E1 NSDHL 0 0 0 171 1 1
CYP2E1 HLF 0 0 145 179 1 1
CYP2E1 SLC26A1 0 0 0 163 1 1
CYP2E1 PLA2G10 0 650 97 670 1 1
CYP2E1 SLC22A12 0 0 107 261 1 1
CYP2E1 CYP3A4 0 900 908 950 1 1
CYP2E1 ABCA1 0 0 181 208 1 2
CYP2E1 MRPS7 0 0 245 244 1 1
CYP2E1 SLC38A4 0 0 57 218 1 1
CYP2E1 AVP 0 0 737 740 1 1
CYP2E1 CCL4 0 0 195 200 1 1
CYP2E1 IL1A 0 0 193 210 1 1
CYP2E1 MAF 0 0 186 186 1 1
CYP2E1 DPP4 0 0 152 247 1 1
CYP2E1 DRD2 0 0 232 231 1 1
CYP2E1 BCHE 0 0 207 241 1 1
CYP2E1 SDR42E1 0 0 49 184 1 1
CYP2E1 MAP3K11 0 0 210 228 1 1
CYP2E1 SULT1A4 0 0 243 305 1 1
CYP2E1 SYCE1 0 0 265 435 1 1
CYP2E1 ALB 0 0 600 646 1 2
CYP2E1 CD68 0 0 209 209 1 2
CYP2E1 CASP8 0 0 298 303 1 2
CYP2E1 ABCC3 0 0 320 342 1 1
CYP2E1 MTG1 0 0 181 608 1 1
CYP2E1 CCL2 0 0 371 371 1 2
CYP2E1 CREB3L3 0 0 166 199 1 1
CYP2E1 SLC22A11 0 0 95 197 1 1
CYP2E1 CYP4F12 0 0 420 416 1 1
CYP2E1 LEPR 0 0 181 203 1 1
CYP2E1 ERO1L 0 0 156 170 1 1
CYP2E1 RASSF6 0 0 49 150 1 1
CYP2E1 HNF1B 0 0 141 192 1 1
CYP2E1 MYLK 0 0 113 174 1 1
CYP2E1 TNFRSF10A 0 0 134 151 1 1
CYP2E1 ABCC4 0 0 260 274 1 1
CYP2E1 ONECUT1 0 0 147 184 1 1
CYP2E1 SMAD3 0 0 168 181 1 2
CYP2E1 PRMT3 0 0 0 156 1 1
CYP2E1 NMRK1 0 0 96 256 1 1
CYP2E1 PKLR 0 0 119 159 1 1
CYP2E1 DDC 0 0 0 151 1 1
CYP2E1 A2ML1 0 0 0 160 1 1
CYP2E1 IL4 0 0 216 216 1 1
CYP2E1 WNT9B 0 0 103 197 1 1
CYP2E1 PRMT6 0 0 0 156 1 1
CYP2E1 PGRMC2 0 0 44 157 1 1
CYP2E1 GPX5 0 0 43 422 1 1
CYP2E1 IMPA2 0 0 81 188 1 1
CYP2E1 SLC17A6 0 0 0 153 1 1
CYP2E1 ADIPOR1 0 0 172 264 1 1
CYP2E1 AGXT2 111 0 92 200 1 1
CYP2E1 HSD17B13 0 0 226 303 1 1
CYP2E1 AGMO 0 0 0 199 1 1
CYP2E1 CYP4F11 0 0 370 402 1 1
CYP2E1 CLEC4F 0 0 134 283 1 1
CYP2E1 FASN 0 0 294 378 1 2
CYP2E1 HNF1A 0 0 480 506 1 1
CYP2E1 AKR1B1 0 900 216 920 1 1
CYP2E1 IGFBP1 0 0 159 184 1 1
CYP2E1 CYP27A1 0 0 369 408 1 1
CYP2E1 EGF 0 0 223 223 1 2
CYP2E1 OGG1 0 0 421 420 1 1
CYP2E1 CYCS 0 0 455 528 1 2
CYP2E1 PLGLB1 0 0 0 223 1 1
CYP2E1 SLC27A5 0 0 249 326 1 1
CYP2E1 SLC22A1 0 0 314 353 1 1
CYP2E1 MAPK9 0 0 286 297 1 2
CYP2E1 SLC1A2 0 0 113 182 1 1
CYP2E1 CASP9 0 0 325 325 1 2
CYP2E1 SQLE 0 0 105 291 1 1
CYP2E1 ALDH1L1 0 0 92 165 1 1
CYP2E1 NMRK2 0 0 0 200 1 1
CYP2E1 PPARA 0 0 620 656 1 2
CYP2E1 TAT 0 0 181 214 1 2
CYP2E1 RDH5 0 0 143 241 1 1
CYP2E1 LPL 0 0 166 165 1 1
CYP2E1 CBR1 0 900 112 910 1 1
CYP2E1 ACHE 0 0 157 193 1 2
CYP2E1 HSP90B1 0 0 182 234 1 1
CYP2E1 CCR2 0 0 156 155 1 2
CYP2E1 PGRMC1 0 0 160 266 1 1
CYP2E1 CRHR1 0 0 96 158 1 1
CYP2E1 B3GAT2 0 0 325 442 1 1
CYP2E1 STK16 0 0 321 321 1 1
CYP2E1 SLC26A2 0 0 0 151 1 1
CYP2E1 HSPA4 0 0 543 608 1 1
CYP2E1 CYP1B1 0 0 777 295 1 1
CYP2E1 CFD 0 0 67 183 1 1
CYP2E1 NR3C1 0 0 234 259 1 1
CYP2E1 FXR1 0 0 397 396 1 1
CYP2E1 CTGF 0 0 193 193 1 1
CYP2E1 CYP2B6 0 900 873 910 1 1
CYP2E1 KDM2A 0 0 0 154 1 1
CYP2E1 CYP3A5 0 0 844 509 1 1
CYP2E1 VEZF1 0 0 388 399 1 1
CYP2E1 HIST2H3PS2 0 0 170 182 1 1
CYP2E1 MTR 0 0 285 284 1 1
CYP2E1 GPX4 0 0 215 428 1 2
CYP2E1 MAP2K4 0 0 150 173 1 1
CYP2E1 HBG1 0 0 151 150 1 1
CYP2E1 ARG1 0 0 166 198 1 2
CYP2E1 MAPK8 0 0 384 423 1 2
CYP2E1 GCLC 0 0 466 487 1 1
CYP2E1 PTGIS 0 0 261 281 1 1
CYP2E1 ADIPOQ 0 0 403 466 1 2
CYP2E1 XRCC1 0 0 500 499 1 1
CYP2E1 SLC47A1 0 0 135 178 1 1
CYP2E1 MMP2 0 0 210 216 1 2
CYP2E1 TBXAS1 0 0 450 408 1 1
CYP2E1 MAT2A 0 0 156 182 1 1
CYP2E1 AWAT1 0 0 287 286 1 1
CYP2E1 RBP4 0 0 165 273 1 1
CYP2E1 KRT8 0 0 181 198 1 1
CYP2E1 SLC7A10 0 0 0 172 1 1
CYP2E1 ALOX15B 0 900 66 906 1 1
CYP2E1 CD8A 0 0 181 181 1 1
CYP2E1 SORD 0 0 229 263 1 1
CYP2E1 IRS2 0 0 183 184 1 1
CYP2E1 CALR 0 0 108 218 1 1
CYP2E1 PEMT 0 0 123 192 1 1
CYP2E1 UGT1A8 0 650 650 890 1 1
CYP2E1 PRDX1 0 0 823 830 1 1
CYP2E1 AASDH 0 0 0 206 1 1
CYP2E1 TTPA 0 0 113 161 1 1
CYP2E1 DUSP22 0 0 157 156 1 1
CYP2E1 P2RY12 0 0 539 539 1 1
CYP2E1 ARNT 0 0 183 201 1 2
CYP2E1 AKR1C2 0 0 134 274 1 1
CYP2E1 LRAT 0 0 109 159 1 1
CYP2E1 LTA 0 0 93 188 1 1
CYP2E1 SOD1 0 0 372 396 1 2
CYP2E1 UGT2B17 0 650 231 771 1 1
CYP2E1 FDPS 0 0 95 151 1 1
CYP2E1 ZCCHC9 0 0 81 180 1 1
CYP2E1 ACAD11 0 0 108 159 1 1
CYP2E1 JUN 0 0 459 539 1 2
CYP2E1 GPSM2 0 0 0 258 1 1
CYP2E1 MGST3 0 650 153 690 1 1
CYP2E1 FMO4 0 0 112 620 1 1
CYP2E1 AMFR 270 0 150 357 1 1
CYP2E1 PFDN2 0 0 0 213 1 1
CYP2E1 SERPINA1 0 0 306 329 1 2
CYP2E1 ENSG00000173366 0 0 151 150 1 1
CYP2E1 CYP19A1 0 0 391 344 1 2
CYP2E1 BCL2L11 0 0 138 157 1 2
CYP2E1 R3HDM4 0 0 0 263 1 1
CYP2E1 KMO 0 0 61 256 1 1
CYP2E1 ABCC5 0 0 244 258 1 1
CYP2E1 GSTA4 0 650 469 817 1 1
CYP2E1 HSPA1A 0 0 90 169 1 1
CYP2E1 HAO2 0 0 91 183 1 1
CYP2E1 NOS1 0 0 142 183 1 1
CYP2E1 CASP1 0 0 217 217 1 2
CYP2E1 CYP4Z1 0 0 218 315 1 1
CYP2E1 ALDH1A3 0 0 161 204 1 2
CYP2E1 CYP7A1 0 900 519 924 1 1
CYP2E1 DNTT 0 0 283 282 1 1
CYP2E1 NNMT 0 0 143 193 1 1
CYP2E1 PI4K2B 0 0 48 152 1 1
CYP2E1 SNCA 0 0 138 175 1 2
CYP2E1 SIRT3 0 0 241 257 1 2
CYP2E1 KEAP1 0 0 416 501 1 2
CYP2E1 MMP9 0 0 244 255 1 2
CYP2E1 MAPK3 0 0 274 296 1 2
CYP2E1 SQSTM1 0 0 165 165 1 2
CYP2E1 PCK2 0 0 127 165 1 1
CYP2E1 CRYZ 0 0 341 365 1 1
CYP2E1 SLC11A2 0 0 90 152 1 1
CYP2E1 KIFC2 0 0 57 158 1 1
CYP2E1 MPND 0 0 52 168 1 1
CYP2E1 INS 0 0 508 509 1 2
CYP2E1 ACTB 0 0 508 541 1 2
CYP2E1 ALDH3A1 0 900 181 953 1 1
CYP2E1 MSMO1 0 0 46 203 1 1
CYP2E1 HOXA5 0 0 0 388 1 1
CYP2E1 FTCD 0 0 76 183 1 1
CYP2E1 STUB1 270 0 151 353 1 2
CYP2E1 GOT1 0 0 149 213 1 1
CYP2E1 DNMT1 0 0 170 170 1 2
CYP2E1 CEBPA 0 0 283 311 1 1
CYP2E1 ACSBG1 0 0 0 152 1 1
CYP2E1 COX4I1 0 0 141 182 1 1
CYP2E1 CRP 0 0 213 251 1 2
CYP2E1 ASS1 0 0 210 268 1 1
CYP2E1 UGT1A3 0 650 407 813 1 1
CYP2E1 SLC51B 0 0 140 173 1 1
CYP2E1 PNPLA2 0 0 182 188 1 2
CYP2E1 HSP90AA1 0 0 809 841 1 2
CYP2E1 HADHA 0 0 117 156 1 1
CYP2E1 NENF 0 0 75 174 1 1
CYP2E1 NPAT 0 0 0 189 1 1
CYP2E1 HPGDS 0 650 681 885 1 1
CYP2E1 ALDOB 0 0 224 266 1 1
CYP2E1 NDUFAF5 0 0 0 156 1 1
CYP2E1 ACSM5 0 0 181 256 1 1
CYP2E1 FOXA3 0 0 170 200 1 1
CYP2E1 ICAM1 0 0 205 219 1 2
CYP2E1 PLA2G2D 0 650 0 650 1 1
CYP2E1 MLKL 0 0 157 170 1 2
CYP2E1 CYP2R1 0 0 324 173 1 1
CYP2E1 SLC10A2 0 0 481 505 1 1
CYP2E1 ADH1B 0 900 682 975 1 1
CYP2E1 CYP2U1 0 900 408 914 1 1
CYP2E1 EHHADH 0 0 138 212 1 1
CYP2E1 ESR2 0 0 134 162 1 1
CYP2E1 ADH7 0 900 506 954 1 1
CYP2E1 FABP5 0 0 123 158 1 1
CYP2E1 PLA2G1B 0 650 150 695 1 1
CYP2E1 TOMM40 0 0 441 441 1 1
CYP2E1 MTTP 0 0 302 333 1 1
CYP2E1 MAT2B 0 0 57 185 1 1
CYP2E1 HSD3B1 0 900 181 927 1 1
CYP2E1 BAX 0 0 174 173 1 2
CYP2E1 METTL7A 0 0 0 165 1 1
CYP2E1 TIMP1 0 0 323 323 1 1
CYP2E1 CHST10 0 0 0 370 1 1
CYP2E1 NDUFAF6 0 0 0 248 1 1
CYP2E1 OAT 0 0 136 178 1 1
CYP2E1 NKRF 0 0 149 164 1 1
CYP2E1 SPP1 0 0 229 228 1 2
CYP2E1 EPCAM 0 0 161 179 1 2
CYP2E1 MOCS2 0 0 0 213 1 1
CYP2E1 AR 0 0 158 186 1 2
CYP2E1 KCNH2 0 0 108 199 1 1
CYP2E1 GSR 0 0 455 471 1 1
CYP2E1 HSPA8 0 0 254 282 1 2
CYP2E1 INSR 0 0 81 174 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0018601 Molecular Function 4-nitrophenol 2-monooxygenase activity enables IDA
GO:0030544 Molecular Function Hsp70 protein binding enables ISS
GO:0051879 Molecular Function Hsp90 protein binding enables ISS
GO:0008392 Molecular Function arachidonic acid epoxygenase activity enables IBA
GO:0070330 Molecular Function aromatase activity enables IEA
GO:0019899 Molecular Function enzyme binding enables IPI
GO:0020037 Molecular Function heme binding enables IBA
GO:0020037 Molecular Function heme binding enables IDA
GO:0005506 Molecular Function iron ion binding enables IEA
GO:0120319 Molecular Function long-chain fatty acid omega-1 hydroxylase activity enables IDA
GO:0004497 Molecular Function monooxygenase activity enables IDA
GO:0004497 Molecular Function monooxygenase activity enables TAS
GO:0016491 Molecular Function oxidoreductase activity enables IDA
GO:0016709 Molecular Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen enables TAS
GO:0016712 Molecular Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enables IBA
GO:0019825 Molecular Function oxygen binding enables TAS
GO:0018960 Biological Process 4-nitrophenol metabolic process involved_in IDA
GO:0018910 Biological Process benzene metabolic process involved_in TAS
GO:0018885 Biological Process carbon tetrachloride metabolic process involved_in TAS
GO:0019373 Biological Process epoxygenase P450 pathway involved_in IBA
GO:0042197 Biological Process halogenated hydrocarbon metabolic process involved_in TAS
GO:0046483 Biological Process heterocycle metabolic process involved_in IDA
GO:0002933 Biological Process lipid hydroxylation involved_in IDA
GO:0042759 Biological Process long-chain fatty acid biosynthetic process involved_in TAS
GO:0001676 Biological Process long-chain fatty acid metabolic process involved_in IDA
GO:0016098 Biological Process monoterpenoid metabolic process involved_in IDA
GO:0009617 Biological Process response to bacterium involved_in IEA
GO:0008202 Biological Process steroid metabolic process involved_in IMP
GO:0006805 Biological Process xenobiotic metabolic process involved_in IBA
GO:0006805 Biological Process xenobiotic metabolic process involved_in IDA
GO:0006805 Biological Process xenobiotic metabolic process involved_in IMP
GO:0006805 Biological Process xenobiotic metabolic process involved_in TAS
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in TAS
GO:0043231 Cellular Component intracellular membrane-bounded organelle is_active_in IBA
GO:0005743 Cellular Component mitochondrial inner membrane located_in ISS
Pathways
Name DB ID
Metabolism Reactome R-HSA-1430728
Biological oxidations Reactome R-HSA-211859
Cytochrome P450 - arranged by substrate type Reactome R-HSA-211897
Phase I - Functionalization of compounds Reactome R-HSA-211945
Xenobiotics Reactome R-HSA-211981
CYP2E1 reactions Reactome R-HSA-211999
Metabolism of lipids Reactome R-HSA-556833
Biosynthesis of DHA-derived SPMs Reactome R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) Reactome R-HSA-9018678
Biosynthesis of maresins Reactome R-HSA-9018682
Biosynthesis of maresin-like SPMs Reactome R-HSA-9027307
Drug ADME Reactome R-HSA-9748784
Aspirin ADME Reactome R-HSA-9749641
Paracetamol ADME Reactome R-HSA-9753281
Ethanol effects on histone modifications (WP3996) WikiPathways WP3996_r107156
Nuclear receptors in lipid metabolism and toxicity (WP299) WikiPathways WP299_r117807
Folate-alcohol and cancer pathway hypotheses (WP1589) WikiPathways WP1589_r122870
Metapathway biotransformation Phase I and II (WP702) WikiPathways WP702_r106643
Metabolism of dichloroethylene by CYP450 (WP3666) WikiPathways WP3666_r117778
Ethanol metabolism production of ROS by CYP2E1 (WP4269) WikiPathways WP4269_r117715
Tamoxifen metabolism (WP691) WikiPathways WP691_r114497
Oxidation by cytochrome P450 (WP43) WikiPathways WP43_r122562
Gut-liver indole metabolism (WP3627) WikiPathways WP3627_r119388
Acrylamide biotransformation and exposure biomarkers (WP4233) WikiPathways WP4233_r117644
Felbamate metabolism (WP2816) WikiPathways WP2816_r117724
Nonalcoholic fatty liver disease (WP4396) WikiPathways WP4396_r123350
Vitamin A and carotenoid metabolism (WP716) WikiPathways WP716_r116512
Fatty acid omega-oxidation (WP206) WikiPathways WP206_r117723
Benzene metabolism (WP3891) WikiPathways WP3891_r106161
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_000773 4 mRNA None NC_000010 Reference