HAdb 2.0 is available now!

DAP

death associated protein
General Information
Name death associated protein
Alias
  • death-associated protein 1
  • DAP-1
Gene_family
organism Homo sapiens
entrez_id 1611
location 5p15.2
transcript_count 2
exon_count 4
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
    Stringdb Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death
    nextProt Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
DAP BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
DAP BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
DAP BioGRID SEC61B GeneID BioGRID Affinity Capture-MS
DAP BioGRID RACK1 GeneID BioGRID Affinity Capture-MS
DAP BioGRID RBM8A GeneID BioGRID Affinity Capture-MS
DAP BioGRID MAN2C1 GeneID BioGRID Affinity Capture-MS
DAP BioGRID HTRA4 GeneID BioGRID Affinity Capture-MS
DAP BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
DAP Protein SETDB1 GeneID HPRD
DAP BioGRID SETDB1 GeneID BioGRID Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
DAP NUDCD3 0 0 0 190 1 1
DAP ULK1 0 0 424 436 1 2
DAP NUDC 0 0 0 400 1 1
DAP SERF1A 0 0 0 304 1 1
DAP PRKAB1 0 0 90 287 1 2
DAP MLLT11 0 0 170 169 1 1
DAP MCM2 0 0 74 231 1 1
DAP HSPB1 0 0 453 469 1 2
DAP ADAM19 0 0 45 210 1 1
DAP FKBP1A 0 0 122 175 1 2
DAP DUSP14 0 0 0 370 1 1
DAP SESN2 0 0 143 175 1 2
DAP MAP1LC3B 0 0 90 238 1 2
DAP CAMK1 0 0 0 431 1 1
DAP PPT1 0 0 134 332 1 1
DAP ATG5 0 0 180 179 1 2
DAP DUSP21 0 0 0 370 1 1
DAP RPTOR 0 0 253 252 1 2
DAP CAPNS1 0 0 0 201 1 2
DAP SERBP1 0 0 0 206 1 1
DAP DPM1 0 0 174 232 1 1
DAP PRKAB2 0 0 54 154 1 1
DAP PRRT2 0 0 140 228 1 1
DAP DGKA 0 0 128 161 1 1
DAP SREBF1 0 0 142 179 1 1
DAP TENM1 0 0 174 173 1 1
DAP TELO2 0 0 143 161 1 1
DAP RRAGB 0 0 135 154 1 1
DAP UBN1 0 0 63 182 1 1
DAP DUSP28 0 0 0 226 1 1
DAP WIPI1 0 0 270 288 1 2
DAP SEPT10 0 0 0 200 1 1
DAP RSL1D1 0 0 233 232 1 1
DAP TRADD 0 0 71 250 1 1
DAP ATG7 0 0 170 169 1 2
DAP TRIM45 0 0 0 370 1 1
DAP ATG16L2 0 0 167 167 1 2
DAP SERF1B 0 0 0 304 1 1
DAP PDAP1 0 0 0 549 1 1
DAP ARPP21 0 0 193 247 1 1
DAP BCL2L13 0 0 0 461 1 2
DAP KRT72 0 0 152 277 1 1
DAP TTI1 0 0 166 172 1 1
DAP TXNDC12 0 0 0 317 1 1
DAP TXNDC17 0 0 218 385 1 1
DAP POU3F1 0 0 0 197 1 1
DAP PATL1 0 0 218 240 1 1
DAP LZTS1 0 0 184 212 1 1
DAP PSMB9 0 0 0 207 1 1
DAP WDR13 0 0 0 207 1 1
DAP EIF4B 0 0 212 212 1 1
DAP DAXX 0 0 101 257 1 1
DAP PSMB6 0 0 0 256 1 1
DAP TFEB 0 0 292 292 1 2
DAP C4BPA 0 0 260 260 1 1
DAP ATG101 0 0 165 189 1 2
DAP SEPT2 0 0 0 167 1 1
DAP HNRNPL 270 0 0 270 1 1
DAP MYT1 0 0 0 213 1 1
DAP BNIP3 0 0 194 199 1 2
DAP ATG13 0 0 465 475 1 2
DAP ATP6V1G2 0 0 0 226 1 1
DAP ULK2 0 0 184 185 1 2
DAP EEF2K 0 0 134 156 1 2
DAP AKT1S1 0 0 173 197 1 1
DAP EIF4EBP2 0 0 167 224 1 1
DAP BECN1 0 0 174 189 1 2
DAP DAPK1 0 0 641 645 1 2
DAP LPIN1 0 0 166 165 1 2
DAP HNRNPAB 0 0 181 201 1 1
DAP TPP1 0 0 66 174 1 1
DAP POLDIP3 0 0 175 175 1 1
DAP TSC1 0 0 206 206 1 2
DAP DEPTOR 0 0 280 306 1 2
DAP FAF1 0 0 0 159 1 1
DAP EIF1 0 0 0 232 1 1
DAP NUBPL 0 0 0 183 1 1
DAP CAPN8 0 0 0 225 1 1
DAP PGD 0 0 95 154 1 1
DAP MLST8 0 0 282 282 1 1
DAP CAMK1D 0 0 0 217 1 1
DAP GFPT2 0 0 141 194 1 1
DAP EIF1B 0 0 0 263 1 1
DAP PERP 0 0 123 181 1 1
DAP MGMT 0 0 112 229 1 2
DAP CADM2 0 0 148 179 1 1
DAP MAP1LC3B2 0 0 0 197 1 1
DAP EIF4EBP1 0 0 249 280 1 2
DAP GRB10 0 0 194 194 1 1
DAP SDF2 0 0 0 224 1 1
DAP ATRX 0 0 61 157 1 1
DAP PRR5 0 0 254 264 1 1
DAP DAPL1 0 0 216 250 1 1
DAP RAB18 0 0 0 651 1 1
DAP TMED10 0 0 0 154 1 1
DAP PSMD5 0 0 0 463 1 1
DAP BCL2L1 0 0 134 155 1 2
DAP SERF2 0 0 0 304 1 1
DAP RPL13 0 0 81 152 1 1
DAP MAF1 0 0 218 378 1 1
DAP TSC2 0 0 213 222 1 2
DAP RETSAT 0 0 0 166 1 1
DAP POP4 0 0 0 293 1 1
DAP NUBP1 0 0 0 440 1 1
DAP RRAGA 0 0 202 202 1 1
DAP ARPP19 0 0 193 243 1 1
DAP UBN2 0 0 108 221 1 1
DAP MTOR 0 0 334 334 1 2
DAP MAPKAP1 0 0 158 207 1 1
DAP FOXO3 0 0 142 169 1 2
DAP GCA 0 0 0 164 1 1
DAP PTAFR 0 0 0 432 1 1
DAP CRADD 0 0 285 284 1 1
DAP C6orf57 0 0 123 177 1 1
DAP CAPNS2 0 0 0 164 1 1
DAP DUSP18 0 0 0 642 1 1
DAP PEF1 0 0 0 453 1 1
DAP PPT2 0 0 0 151 1 1
DAP RPS6KB1 0 0 195 195 1 2
DAP EIF4E 0 0 162 161 1 2
DAP FADD 0 0 71 194 1 2
DAP TRIM24 0 0 160 159 1 1
DAP DGKH 0 0 185 185 1 1
DAP SGK1 0 0 165 171 1 2
DAP ADAM9 0 0 0 168 1 1
DAP FAF2 0 0 171 203 1 1
DAP NUBP2 0 0 0 183 1 1
DAP ATG2A 0 0 170 169 1 2
DAP HTRA4 270 0 0 270 1 1
DAP CHGB 0 0 123 157 1 1
DAP SSR3 0 0 0 183 1 1
DAP RHEB 0 0 245 310 1 2
DAP PDCD6 0 0 0 164 1 1
DAP PDCD6IP 0 0 0 190 1 1
DAP WIPI2 0 0 384 426 1 2
DAP RICTOR 0 0 232 231 1 2
DAP P4HB 0 0 0 156 1 2
DAP ATP6V1G1 0 0 0 226 1 1
DAP NUDCD2 0 0 0 190 1 1
DAP SDK2 0 0 216 296 1 1
DAP ATP6V1G3 0 0 0 194 1 1
DAP KIAA0141 0 0 324 323 1 1
DAP CAPN13 0 0 0 226 1 1
DAP CYB5A 0 0 107 157 1 1
DAP SSR4 0 0 0 187 1 1
DAP LARP1 0 0 166 165 1 1
DAP RB1CC1 0 0 325 325 1 2
DAP SRI 0 0 0 164 1 1
DAP RPL7A 0 0 166 201 1 1
DAP SDF2L1 0 0 0 557 1 1
DAP DGUOK 0 0 166 223 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0070513 Molecular Function death domain binding enables IBA
GO:0070513 Molecular Function death domain binding enables IPI
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in IMP
GO:0006915 Biological Process apoptotic process acts_upstream_of_or_within IGI
GO:0097190 Biological Process apoptotic signaling pathway involved_in IBA
GO:0097190 Biological Process apoptotic signaling pathway involved_in IMP
GO:0006914 Biological Process autophagy involved_in IEA
GO:0034198 Biological Process cellular response to amino acid starvation involved_in IBA
GO:0034198 Biological Process cellular response to amino acid starvation involved_in IDA
GO:0045892 Biological Process negative regulation of DNA-templated transcription involved_in IMP
GO:0032088 Biological Process negative regulation of NF-kappaB transcription factor activity involved_in IMP
GO:0010507 Biological Process negative regulation of autophagy involved_in IBA
GO:0010507 Biological Process negative regulation of autophagy involved_in IMP
GO:0006417 Biological Process regulation of translation involved_in IEA
Pathways
Name DB ID
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001291963 2 mRNA transcript variant 1 NC_000005 Reference
NM_004394 3 mRNA transcript variant 2 NC_000005 Reference