HAdb 2.0 is available now!

DBP

D-box binding PAR bZIP transcription factor
General Information
Name D-box binding PAR bZIP transcription factor
Alias
  • D site-binding protein
  • D site of albumin promoter (albumin D-box) binding protein
  • albumin D box-binding protein
  • albumin D-element-binding protein
  • tax-responsive enhancer element-binding protein 302
Gene_family PAR bZIP family
organism Homo sapiens
entrez_id 1628
location 19q13.33
transcript_count 1
exon_count 4
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]
    Stringdb D site-binding protein; This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation; Belongs to the bZIP family. PAR subfamily
    nextProt This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
DBP BioGRID DDX39A GeneID BioGRID Affinity Capture-RNA
DBP BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
DBP BioGRID IFI16 GeneID BioGRID Affinity Capture-MS
DBP BioGRID CLOCK GeneID BioGRID Two-hybrid
DBP BioGRID BATF2 GeneID BioGRID FRET
DBP BioGRID BATF3 GeneID BioGRID FRET
DBP BioGRID BATF GeneID BioGRID FRET
DBP BioGRID EPAS1 GeneID BioGRID FRET
DBP BioGRID DDIT3 GeneID BioGRID FRET; Two-hybrid
DBP BioGRID CEBPG GeneID BioGRID FRET
DBP BioGRID CEBPA GeneID BioGRID FRET
DBP BioGRID ATF3 GeneID BioGRID FRET
DBP BioGRID HLF GeneID BioGRID Two-hybrid
DBP Protein EP300 GeneID HPRD
DBP Protein TEF GeneID HPRD
DBP Protein HLF GeneID HPRD
DBP Protein CEBPA GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
DBP DEPDC5 0 0 0 197 1 1
DBP MAT2A 0 0 0 167 1 1
DBP CREB3 0 0 181 181 1 1
DBP NCOA3 0 0 0 161 1 1
DBP TSHB 0 0 609 609 1 1
DBP TCF7 0 0 0 223 1 1
DBP INSIG2 0 0 301 302 1 1
DBP NEIL1 0 0 72 413 1 1
DBP PSMD1 0 0 0 206 1 1
DBP CSNK1A1 0 0 109 153 1 1
DBP ARNT 0 0 128 306 1 2
DBP PHF5A 0 0 45 154 1 1
DBP FUT2 0 0 66 296 1 1
DBP JUN 0 0 100 188 1 2
DBP BATF 271 0 0 309 1 1
DBP NCOA2 0 0 0 161 1 1
DBP CYP7A1 0 0 450 458 1 1
DBP PER2 0 0 653 712 1 1
DBP INS 0 0 206 206 1 2
DBP TLE6 0 0 535 552 1 1
DBP CSNK1E 0 0 392 434 1 1
DBP KLF15 0 0 101 177 1 1
DBP OPN4 0 0 261 272 1 1
DBP LARGE 0 0 166 165 1 1
DBP IL3 0 0 218 222 1 1
DBP SLC9A3 0 0 124 153 1 1
DBP CEBPA 465 0 286 609 1 1
DBP DEC1 0 0 470 470 1 1
DBP ARNTL2 0 0 391 518 1 1
DBP NELFE 0 0 108 163 1 1
DBP ELOVL3 0 0 144 231 1 1
DBP LDLRAP1 0 0 194 246 1 1
DBP NR1D2 0 0 509 921 1 1
DBP SFTPB 0 0 425 425 1 1
DBP TCF7L1 0 0 0 223 1 1
DBP KDM1A 0 0 45 155 1 2
DBP HNRNPM 0 0 0 167 1 1
DBP SLC15A1 0 0 184 202 1 1
DBP CIART 0 0 421 463 1 1
DBP KMT2B 0 0 0 154 1 1
DBP SLC37A2 0 0 183 200 1 1
DBP HLF 272 0 720 345 1 1
DBP KDM8 0 0 218 218 1 1
DBP NFIL3 0 0 681 305 1 1
DBP AANAT 0 0 180 194 1 1
DBP SCML1 0 0 241 257 1 1
DBP LONRF3 0 0 0 239 1 1
DBP FXYD4 0 0 171 171 1 1
DBP CUX1 0 0 0 216 1 1
DBP ALB 0 0 451 451 1 2
DBP TMEM14A 0 0 193 214 1 1
DBP CSNK1D 0 0 307 355 1 1
DBP AP1M1 0 0 0 167 1 1
DBP DUX4L3 0 0 194 247 1 1
DBP EP300 213 0 135 303 1 2
DBP LEF1 0 0 0 223 1 1
DBP HNF1B 0 0 155 500 1 1
DBP MAD1L1 0 0 0 151 1 1
DBP ANXA8 0 0 535 535 1 1
DBP ONECUT1 0 0 241 256 1 1
DBP CRY2 0 0 651 666 1 1
DBP DDX19B 0 0 225 224 1 1
DBP ESCO2 0 0 0 150 1 1
DBP HNF1A 0 0 211 350 1 1
DBP CYP27A1 0 0 143 156 1 1
DBP PXMP4 0 0 222 228 1 1
DBP PER3 0 0 617 811 1 1
DBP PPARA 0 0 341 378 1 2
DBP BATF3 271 0 0 309 1 1
DBP NR3C1 0 0 175 204 1 1
DBP ZNF597 0 0 193 237 1 1
DBP BHLHE40 0 0 322 365 1 1
DBP STXBP6 0 0 48 253 1 1
DBP FBXL3 0 0 321 339 1 1
DBP TCF3 0 0 329 368 1 1
DBP CLOCK 299 900 654 990 1 2
DBP NR0B2 0 0 207 234 1 1
DBP SDS 0 0 252 286 1 1
DBP LONRF1 0 0 163 617 1 1
DBP PPARGC1A 0 0 167 167 1 2
DBP WDR64 0 0 0 193 1 1
DBP AP4M1 0 0 0 167 1 1
DBP AP5M1 0 0 0 167 1 1
DBP G6PC 0 0 150 174 1 1
DBP MYLK4 0 0 173 179 1 1
DBP EFTUD2 0 0 0 191 1 1
DBP SERPINA6 0 0 90 155 1 1
DBP RIOK1 0 0 125 221 1 1
DBP NR1I3 0 0 247 289 1 1
DBP SLC5A1 0 0 161 175 1 1
DBP EMX2 0 0 0 167 1 1
DBP MSRB3 0 0 114 348 1 1
DBP SFPQ 0 0 155 154 1 1
DBP NCOA1 0 0 0 161 1 1
DBP COQ10B 0 0 194 228 1 1
DBP DHRS7 0 0 66 260 1 1
DBP INSIG1 0 0 180 179 1 1
DBP CCRN4L 0 0 302 302 1 1
DBP OSBPL5 0 0 167 219 1 1
DBP EMX1 0 0 0 219 1 1
DBP DDIT3 305 0 0 305 1 2
DBP SEC61A1 0 0 0 245 1 1
DBP HNRNPLL 0 0 45 209 1 1
DBP NPAS2 0 900 606 972 1 1
DBP PLEK 0 0 0 197 1 1
DBP BATF2 271 0 0 309 1 1
DBP MATN4 0 0 127 160 1 1
DBP WDR76 0 0 216 630 1 1
DBP SIRT5 0 0 140 188 1 1
DBP RETSAT 0 0 154 166 1 1
DBP PASK 0 0 0 159 1 1
DBP LONRF2 0 0 0 252 1 1
DBP ME1 0 0 163 178 1 1
DBP RORA 0 0 362 403 1 1
DBP USP47 0 0 0 195 1 1
DBP TCF7L2 0 0 0 223 1 1
DBP PDXK 0 0 723 723 1 1
DBP ESRRA 0 0 66 461 1 1
DBP ZNF394 0 0 217 230 1 1
DBP CREB1 0 0 95 207 1 2
DBP RPS3 0 0 0 173 1 1
DBP TEF 213 0 767 730 1 1
DBP ATF5 0 0 0 278 1 1
DBP TRIP12 0 0 0 154 1 1
DBP BTRC 0 0 0 193 1 1
DBP LHX4 0 0 0 154 1 1
DBP EPAS1 271 0 0 281 1 2
DBP IRF2BPL 0 0 0 167 1 1
DBP FGL1 0 0 134 156 1 1
DBP FOS 0 0 142 187 1 2
DBP PRDM8 0 0 0 151 1 1
DBP NCCRP1 0 0 0 223 1 1
DBP NOLC1 0 0 134 216 1 1
DBP TIMELESS 0 0 268 380 1 1
DBP CREBRF 0 0 0 160 1 1
DBP SRPX2 0 0 570 570 1 1
DBP ESRRG 0 0 0 168 1 1
DBP CEBPB 0 0 325 325 1 2
DBP AP1M2 0 0 0 167 1 1
DBP HDAC1 0 0 97 156 1 2
DBP GSK3B 0 0 120 150 1 2
DBP GK 0 0 169 174 1 1
DBP WDR41 0 0 157 156 1 1
DBP SPATA24 0 0 236 236 1 1
DBP CA11 0 0 243 323 1 1
DBP GNG3 0 0 167 167 1 1
DBP PRDM9 0 0 0 151 1 1
DBP NAMPT 0 0 232 288 1 2
DBP GFAP 0 0 0 190 1 2
DBP SYT2 0 0 0 191 1 1
DBP BHLHE41 0 0 557 606 1 1
DBP SREBF1 0 0 167 220 1 1
DBP RORC 0 0 306 341 1 1
DBP RORB 0 0 358 407 1 1
DBP PDK4 0 0 164 163 1 1
DBP SIRT1 0 0 231 344 1 2
DBP F9 0 0 211 223 1 1
DBP IRF2BP2 0 0 0 167 1 1
DBP PPIL1 0 0 61 160 1 1
DBP CRH 0 0 108 175 1 1
DBP CAMK2G 0 0 0 206 1 1
DBP LRP10 0 0 162 191 1 1
DBP FUT1 0 0 96 433 1 1
DBP PAQR3 0 0 181 218 1 2
DBP ESRP1 0 0 0 163 1 1
DBP RABL3 0 0 210 210 1 1
DBP THRSP 0 0 203 214 1 1
DBP KMT2A 0 0 0 181 1 1
DBP IFI16 270 0 0 270 1 1
DBP TLE2 0 0 518 536 1 1
DBP GSTP1 0 0 0 214 1 1
DBP ARNTL 0 900 739 992 1 1
DBP ESRRB 0 0 60 185 1 1
DBP SEC61A2 0 0 0 189 1 1
DBP ATF3 271 0 0 309 1 2
DBP SIN3A 0 0 92 194 1 1
DBP GSAP 0 0 167 167 1 1
DBP ARNT2 0 0 0 203 1 1
DBP SMARCD1 0 0 101 160 1 1
DBP PRDM5 0 0 0 151 1 1
DBP DMPK 0 0 109 179 1 1
DBP ZNF207 0 0 0 177 1 1
DBP PIGZ 0 0 0 299 1 1
DBP ATXN2L 0 0 0 167 1 1
DBP NR1D1 0 0 710 889 1 2
DBP RANBP3L 0 0 213 213 1 1
DBP ACOT13 0 0 181 181 1 1
DBP KLF9 0 0 118 191 1 1
DBP TMEM243 0 0 0 252 1 1
DBP CLK1 0 0 154 179 1 1
DBP PAGE5 0 0 181 181 1 1
DBP GRIA1 0 0 47 253 1 1
DBP IRF2BP1 0 0 0 167 1 1
DBP HMGCR 0 0 218 226 1 1
DBP PROK2 0 0 124 161 1 1
DBP ENPP5 0 0 156 185 1 1
DBP PER1 0 0 392 591 1 1
DBP NCOR1 0 0 143 162 1 1
DBP DDB2 0 0 74 424 1 1
DBP XAGE5 0 0 285 284 1 1
DBP ADRA2C 0 0 140 176 1 1
DBP PRPF19 0 0 0 203 1 1
DBP PRSS50 0 0 155 296 1 1
DBP TFCP2 0 0 104 163 1 1
DBP MRPL4 0 0 172 190 1 1
DBP SIN3B 0 0 157 251 1 1
DBP USP2 0 0 174 231 1 1
DBP CRY1 0 0 701 714 1 1
DBP CREB5 0 0 91 154 1 1
DBP CUX2 0 0 0 155 1 1
DBP ATXN2 0 0 0 167 1 1
DBP HNF4A 0 0 201 250 1 1
DBP PRDM6 0 0 0 151 1 1
DBP FBXW11 0 0 0 193 1 1
DBP SF3B1 0 0 0 231 1 1
DBP KDM5A 0 0 167 185 1 1
DBP FOXA1 0 0 71 188 1 1
DBP CYP8B1 0 0 223 235 1 1
DBP ATF1 0 0 0 160 1 1
DBP ATF4 0 0 0 278 1 2
DBP PPARG 0 0 194 222 1 2
DBP LHX3 0 0 0 154 1 1
DBP PRDM4 0 0 0 151 1 1
DBP RAI1 0 0 65 264 1 1
DBP CEBPG 271 0 106 346 1 1
DBP BRDT 0 0 66 162 1 1
DBP CA10 0 0 123 480 1 1
DBP ALAS1 0 0 184 196 1 1
DBP SF1 0 0 0 189 1 1
DBP GYS2 0 0 115 188 1 1
DBP NR1I2 0 0 134 178 1 1
DBP CREM 0 0 0 160 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0001228 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific enables IDA
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables IBA
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables ISA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IBA
GO:0000977 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:1990837 Molecular Function sequence-specific double-stranded DNA binding enables IDA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0006357 Biological Process regulation of transcription by RNA polymerase II involved_in IBA
GO:0006357 Biological Process regulation of transcription by RNA polymerase II involved_in NAS
GO:0048511 Biological Process rhythmic process involved_in IEA
GO:0090575 Cellular Component RNA polymerase II transcription regulator complex part_of IPI
GO:0000785 Cellular Component chromatin part_of ISA
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus located_in NAS
Pathways
Name DB ID
BMAL1:CLOCK,NPAS2 activates circadian gene expression Reactome R-HSA-1368108
Circadian Clock Reactome R-HSA-400253
7-oxo-C and 7-beta-HC pathways (WP5064) WikiPathways WP5064_r120384
Circadian rhythm genes (WP3594) WikiPathways WP3594_r117682
Oxysterols derived from cholesterol (WP4545) WikiPathways WP4545_r123863
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001352 5 mRNA None NC_000019 Reference