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AGER

advanced glycosylation end-product specific receptor
General Information
Name advanced glycosylation end-product specific receptor
Alias
  • advanced glycosylation end product-specific receptor
  • receptor for advanced glycation end-products
Gene_family Scavenger receptors|C2-set domain containing
organism Homo sapiens
entrez_id 177
location 6p21.32
transcript_count 13
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
    Stringdb Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S [...]
    nextProt Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
AGER BioGRID FPR2 GeneID BioGRID Affinity Capture-Western
AGER BioGRID FPR1 GeneID BioGRID Affinity Capture-Western
AGER BioGRID FBXW7 GeneID BioGRID Affinity Capture-Western
AGER BioGRID ITGB1 GeneID BioGRID Proximity Label-MS
AGER BioGRID CMTM7 GeneID BioGRID Two-hybrid
AGER BioGRID C3orf52 GeneID BioGRID Two-hybrid
AGER BioGRID KRAS GeneID BioGRID Affinity Capture-Western
AGER BioGRID HMGB1 GeneID BioGRID Affinity Capture-Western
AGER BioGRID CREB3 GeneID BioGRID Two-hybrid
AGER BioGRID S100B GeneID BioGRID Affinity Capture-Western
AGER BioGRID FGFR1 GeneID BioGRID Affinity Capture-Western
AGER BioGRID FGF2 GeneID BioGRID Affinity Capture-Western
AGER BioGRID NRP1 GeneID BioGRID Affinity Capture-MS
AGER BioGRID CSTF2 GeneID BioGRID Affinity Capture-MS
AGER BioGRID GRB2 GeneID BioGRID Affinity Capture-MS
AGER BioGRID APP GeneID BioGRID Reconstituted Complex
AGER BioGRID SEC61B GeneID BioGRID Affinity Capture-Western
AGER Protein S100A12 GeneID HPRD
AGER Protein S100P GeneID HPRD
AGER Protein S100B GeneID HPRD
AGER Protein S100A1 GeneID HPRD
AGER Protein TTR GeneID HPRD
AGER Protein HMGB1 GeneID HPRD
AGER BioGRID S100P GeneID BioGRID Affinity Capture-Western
StringDB
A B experiments database textmining combined score hadb nhadb
AGER TSLP 0 0 171 171 1 1
AGER LEPREL2 0 0 134 204 1 1
AGER SERPINE1 0 0 460 459 1 1
AGER SLC2A1 0 0 377 377 1 2
AGER CCDC38 0 0 249 303 1 1
AGER MUC1 0 0 269 269 1 1
AGER MYD88 270 0 498 667 1 2
AGER AGTR1 0 0 476 476 1 1
AGER EGFR 270 0 233 416 1 2
AGER KRT20 0 0 0 303 1 1
AGER LCN2 0 0 294 294 1 1
AGER TP53 0 0 438 438 1 2
AGER IRS1 0 0 261 261 1 2
AGER P2RY10 0 0 143 168 1 1
AGER CFDP1 0 0 208 262 1 1
AGER S100A1 658 0 566 845 1 1
AGER HMGCR 0 0 294 294 1 1
AGER SIGLEC10 0 0 378 378 1 1
AGER MTHFR 0 0 171 171 1 1
AGER SLC7A5 0 0 135 154 1 1
AGER ICAM2 0 0 204 204 1 1
AGER SELPLG 0 0 214 254 1 1
AGER ABCG2 0 0 183 183 1 1
AGER ANXA2 0 0 213 213 1 1
AGER GIG25 0 0 209 209 1 1
AGER TNFRSF11B 0 0 229 228 1 1
AGER CD200R1 0 0 205 205 1 1
AGER NCF1 0 0 297 314 1 1
AGER CD36 0 0 150 282 1 2
AGER PPT2 0 0 391 404 1 1
AGER IRAK1 0 0 184 237 1 1
AGER CSF3 0 0 304 304 1 1
AGER NOS3 0 0 407 407 1 2
AGER CLIC3 0 0 49 168 1 1
AGER CD274 0 0 169 169 1 2
AGER CAMP 0 0 335 351 1 2
AGER MRPL43 0 0 67 164 1 1
AGER CCND1 0 0 171 171 1 2
AGER TRAF1 0 0 0 154 1 1
AGER FGF7 0 0 170 169 1 1
AGER TIMD4 0 0 284 284 1 1
AGER CRTAC1 0 0 63 459 1 1
AGER CYBA 0 0 243 270 1 1
AGER TMEM100 0 0 137 247 1 1
AGER CLU 0 0 501 501 1 2
AGER CTLA4 0 0 181 238 1 2
AGER LDLR 0 0 362 362 1 2
AGER SFTPC 0 0 339 461 1 1
AGER OPALIN 0 0 73 216 1 1
AGER JAK2 0 800 166 828 1 2
AGER HLA-DQB1 0 0 193 193 1 1
AGER CHRNA3 0 0 299 299 1 1
AGER S100A5 0 0 325 325 1 1
AGER PTX3 0 0 316 315 1 1
AGER ENSG00000264813 0 0 414 414 1 1
AGER THSD4 0 0 504 504 1 1
AGER SFTPD 0 0 566 712 1 1
AGER MXRA5 0 0 48 521 1 1
AGER HGF 0 0 212 212 1 2
AGER CCDC137 0 0 122 600 1 1
AGER TXN 0 0 203 203 1 1
AGER S100A10 0 0 174 173 1 1
AGER GDNF 0 0 156 155 1 2
AGER FCHO1 0 0 52 174 1 1
AGER STAT3 0 0 390 390 1 2
AGER PID1 0 0 392 430 1 1
AGER HAGH 0 0 231 230 1 1
AGER ADAMTS3 0 0 181 181 1 1
AGER ABCA3 0 0 167 252 1 1
AGER CACYBP 0 0 216 216 1 1
AGER TCF21 0 0 88 183 1 1
AGER IDE 0 0 560 560 1 1
AGER PECAM1 0 0 325 325 1 1
AGER CAT 0 0 295 295 1 2
AGER IGF1R 0 0 139 154 1 2
AGER TIRAP 270 0 323 537 1 1
AGER GPSM3 0 0 233 281 1 1
AGER ADAM10 0 0 504 504 1 1
AGER TNF 0 0 612 621 1 2
AGER TREM1 0 0 661 673 1 1
AGER PPARGC1A 0 0 166 165 1 2
AGER S100Z 0 0 290 290 1 1
AGER IL1RN 0 0 250 268 1 1
AGER S100A7 0 0 772 772 1 1
AGER MMP3 0 0 342 342 1 1
AGER APEX1 0 0 851 851 1 1
AGER IL1R1 0 0 294 318 1 1
AGER DAAM2 0 0 124 166 1 1
AGER VDR 0 0 155 154 1 2
AGER CD44 0 0 207 207 1 2
AGER IFNA1 0 0 266 266 1 1
AGER BDNF 102 0 373 412 1 2
AGER IL18 0 0 452 452 1 2
AGER AQP5 0 0 283 325 1 1
AGER NCSTN 0 0 294 294 1 1
AGER ADAMTS4 0 0 171 171 1 1
AGER NAPSA 0 0 74 152 1 1
AGER MMP7 0 0 228 227 1 1
AGER CD300LF 0 0 81 307 1 1
AGER HHIP 0 0 427 431 1 1
AGER SCGB3A2 0 0 45 362 1 1
AGER MEFV 0 0 283 282 1 1
AGER SMPD2 0 0 357 375 1 1
AGER GSTCD 0 0 560 571 1 1
AGER ADORA1 0 0 151 150 1 1
AGER RBFOX3 0 0 170 169 1 1
AGER APOH 0 0 161 161 1 1
AGER CD300A 0 0 108 598 1 1
AGER GCG 0 0 211 211 1 1
AGER IREB2 0 0 223 235 1 1
AGER PTCH1 0 0 162 161 1 1
AGER NFKB2 0 900 74 908 1 1
AGER SFTPA2 0 0 122 353 1 1
AGER IL1RL2 0 0 0 233 1 1
AGER VWF 0 0 414 426 1 1
AGER IL5 0 0 258 258 1 1
AGER SLC34A2 0 0 72 208 1 1
AGER CHI3L1 0 0 181 181 1 1
AGER AGT 0 0 195 195 1 1
AGER TXNIP 0 0 217 234 1 2
AGER S100A14 0 0 448 448 1 1
AGER MMP8 0 0 270 270 1 1
AGER TTN 0 0 66 166 1 1
AGER ENSG00000196136 0 0 209 209 1 1
AGER RELB 0 0 123 155 1 2
AGER S100A9 0 0 509 523 1 1
AGER FGF2 270 0 289 458 1 2
AGER CCL21 0 0 166 165 1 1
AGER CDH5 0 0 284 284 1 1
AGER RETN 0 0 213 236 1 1
AGER CD80 0 0 235 235 1 2
AGER OSM 0 0 156 186 1 1
AGER AQP1 0 0 146 176 1 1
AGER TLR1 0 0 321 345 1 1
AGER PAPPA 0 0 244 243 1 1
AGER MERTK 0 0 165 178 1 1
AGER NFE2L2 0 0 266 266 1 2
AGER CSF1R 0 0 203 203 1 1
AGER APOB 0 0 171 171 1 2
AGER MAPK1 0 600 134 638 1 2
AGER IRF7 0 0 152 192 1 1
AGER IGF1 0 0 323 323 1 2
AGER IFNG 0 0 325 325 1 2
AGER CLEC3B 0 0 103 159 1 1
AGER GSDMD 0 0 181 198 1 2
AGER CREB1 0 0 265 265 1 2
AGER HCST 0 0 444 464 1 1
AGER SDF4 0 0 399 399 1 1
AGER GPT 0 0 234 249 1 1
AGER CCL5 0 0 358 358 1 2
AGER ABCA12 0 0 0 210 1 1
AGER CXCL10 0 0 299 314 1 2
AGER HAVCR1 0 0 161 161 1 1
AGER EDNRB 0 0 128 151 1 1
AGER NOTCH4 0 0 297 324 1 1
AGER AXL 0 0 147 161 1 2
AGER MMAB 0 0 52 569 1 1
AGER CRTAP 0 0 0 447 1 1
AGER ZKSCAN3 0 0 210 210 1 2
AGER CLDN18 0 0 182 344 1 1
AGER DIAPH1 270 800 561 931 1 1
AGER TLR9 0 0 609 624 1 2
AGER SIRT2 0 0 155 154 1 2
AGER C5AR1 0 0 203 203 1 1
AGER CXCL13 0 0 134 173 1 1
AGER EPO 0 0 233 232 1 2
AGER LTB4R 0 0 709 718 1 1
AGER VLDLR 0 0 175 175 1 1
AGER LPCAT1 0 0 74 360 1 1
AGER FAM13A 0 0 518 533 1 1
AGER ANXA5 0 0 252 252 1 2
AGER HOPX 0 0 160 159 1 1
AGER S100A2 0 0 370 370 1 1
AGER ESAM 0 0 181 181 1 1
AGER HSPD1 0 0 150 169 1 1
AGER IRF3 0 0 248 248 1 2
AGER NGF 0 0 293 293 1 2
AGER TAGLN 0 0 208 208 1 1
AGER ECE1 0 0 171 171 1 1
AGER CD34 0 0 181 181 1 2
AGER ARG2 0 0 155 154 1 1
AGER HMGB2 0 0 454 466 1 1
AGER SLC5A4 0 0 219 219 1 1
AGER MAPK8IP1 0 0 307 307 1 1
AGER CSF2 0 0 335 335 1 1
AGER LY96 0 0 328 328 1 1
AGER NFKB1 0 900 305 927 1 2
AGER CCL4L1 0 0 168 167 1 1
AGER PPARG 0 0 391 390 1 2
AGER MFAP2 0 0 122 162 1 1
AGER AKT1 0 0 466 488 1 2
AGER RELA 0 900 181 914 1 2
AGER BCL2L1 0 0 181 181 1 2
AGER TGFB2 0 0 193 193 1 1
AGER C2orf15 236 0 0 236 1 1
AGER VCAM1 0 0 528 528 1 1
AGER S100G 0 0 259 304 1 1
AGER CALCR 0 0 75 183 1 1
AGER CD4 0 0 380 401 1 2
AGER ITGA4 0 0 124 160 1 1
AGER INTS12 0 0 468 506 1 1
AGER CASP6 0 0 305 305 1 1
AGER CLEC7A 0 0 143 168 1 1
AGER TLR10 0 0 218 218 1 1
AGER APOA1 0 0 245 244 1 1
AGER PANX1 0 0 195 195 1 1
AGER DUOX1 0 0 236 236 1 1
AGER IKBKB 0 0 244 256 1 2
AGER NLRC4 0 0 213 251 1 2
AGER NOS2 0 0 300 300 1 2
AGER NTRK2 0 0 141 155 1 1
AGER CX3CL1 0 0 327 327 1 1
AGER MAP2K7 0 0 205 205 1 1
AGER CAPZA1 0 650 0 650 1 1
AGER FGFR1 270 0 142 346 1 1
AGER RUNX2 0 0 210 210 1 2
AGER SMAD2 0 0 193 193 1 2
AGER FAM107A 0 0 155 154 1 1
AGER TLR4 0 0 986 986 1 2
AGER STK19 0 0 118 223 1 1
AGER GAPDH 0 0 394 394 1 2
AGER NOX4 0 800 282 850 1 2
AGER CST3 0 0 285 284 1 1
AGER NDNF 0 0 57 237 1 1
AGER CXCL8 0 0 634 642 1 2
AGER PPBP 0 0 138 176 1 1
AGER TICAM2 270 0 0 270 1 1
AGER STAB1 0 0 213 213 1 1
AGER DDOST 0 0 621 621 1 1
AGER EGFL6 0 0 46 229 1 1
AGER FOXP3 0 0 170 190 1 2
AGER HMOX1 0 0 358 358 1 2
AGER IL6R 0 0 167 181 1 1
AGER EDN1 0 0 390 390 1 1
AGER HIF1A 0 0 341 341 1 2
AGER KDR 0 0 194 194 1 2
AGER MMP12 0 0 260 260 1 1
AGER PRKCB 0 0 181 181 1 2
AGER F11 0 0 387 386 1 1
AGER ATF6B 0 0 166 165 1 1
AGER AGTR2 0 0 181 181 1 1
AGER IL1B 0 0 653 659 1 2
AGER MAPKAPK5 417 0 61 429 1 1
AGER TGFB1 0 0 323 356 1 2
AGER DDR2 0 0 154 153 1 1
AGER CXCR2 0 0 249 248 1 1
AGER F2R 0 0 210 210 1 1
AGER SCGB1A1 0 0 464 645 1 1
AGER PF4 0 0 171 189 1 1
AGER TNFRSF1B 0 0 161 181 1 1
AGER CTNNB1 0 0 286 286 1 2
AGER KCNE2 0 0 111 153 1 1
AGER HRAS 0 800 243 842 1 2
AGER FCGR3A 0 0 158 176 1 1
AGER APLP2 0 0 355 355 1 1
AGER RIPK3 0 0 166 214 1 2
AGER APP 42 600 601 833 1 2
AGER FKBPL 0 0 143 196 1 1
AGER EGR1 0 0 239 238 1 2
AGER SLC2A4 0 0 202 202 1 1
AGER ZNF674 0 0 91 405 1 1
AGER MTOR 0 0 269 269 1 2
AGER BBOX1 0 0 233 232 1 1
AGER APOE 0 0 566 566 1 2
AGER NLRP1 0 0 262 262 1 1
AGER SAA1 0 600 235 680 1 1
AGER SPATA9 0 0 284 336 1 1
AGER BGLAP 0 0 181 204 1 1
AGER CD47 0 0 325 325 1 2
AGER CD163 0 0 246 245 1 1
AGER PSMC6 0 0 520 520 1 1
AGER C4A 0 0 204 240 1 1
AGER TNFSF11 0 0 234 234 1 2
AGER DGKK 0 0 67 311 1 1
AGER PSEN2 0 0 273 273 1 1
AGER CXCR4 0 0 390 412 1 2
AGER CDC42 0 0 322 321 1 2
AGER CD40LG 0 0 282 282 1 1
AGER HP 0 0 207 207 1 1
AGER S100A3 0 0 161 175 1 1
AGER MMP1 0 0 294 294 1 1
AGER NOTCH1 0 0 193 232 1 2
AGER SRC 0 0 292 321 1 2
AGER ENTPD1 0 0 155 154 1 1
AGER FLT1 0 0 182 181 1 1
AGER STAT1 0 0 195 195 1 2
AGER FN3K 0 0 203 203 1 1
AGER MIF 0 0 242 241 1 2
AGER OCLN 0 0 374 374 1 1
AGER LGALS3 0 0 451 451 1 2
AGER TLR3 0 0 396 396 1 2
AGER TNFRSF1A 0 0 294 294 1 1
AGER NPNT 0 0 374 404 1 1
AGER NPHS1 0 0 153 152 1 1
AGER MPO 0 0 466 465 1 2
AGER ACAN 0 0 204 204 1 1
AGER S100A6 800 0 955 991 1 1
AGER F11R 0 0 187 187 1 1
AGER IL6 0 0 661 661 1 2
AGER A2M 0 0 306 321 1 1
AGER EIF2AK3 0 0 222 222 1 2
AGER MOG 0 0 122 347 1 1
AGER SERPINB7 0 0 240 239 1 1
AGER CNDP1 0 0 125 167 1 1
AGER AHSG 0 0 217 217 1 1
AGER ADORA2A 0 0 154 184 1 1
AGER ICAM1 0 0 556 556 1 2
AGER CDC123 0 0 113 168 1 1
AGER CD24 0 0 509 509 1 2
AGER RIPK1 0 0 167 186 1 2
AGER SOX9 0 0 117 172 1 1
AGER CCT4 0 0 208 208 1 1
AGER SIRT7 0 0 157 156 1 2
AGER CSF1 0 0 261 261 1 1
AGER ABCA13 0 0 0 386 1 1
AGER HMGB3 0 0 664 670 1 1
AGER CXCR1 0 0 134 154 1 1
AGER NOD2 0 0 203 242 1 2
AGER FEN1 0 0 271 271 1 1
AGER PTPRC 0 0 251 273 1 1
AGER MLKL 0 0 182 195 1 2
AGER SEMA4A 0 0 0 219 1 1
AGER CEBPB 0 0 150 171 1 2
AGER GPIHBP1 0 0 71 162 1 1
AGER GPR126 0 0 292 293 1 1
AGER CXCL12 0 0 550 550 1 2
AGER CCL18 0 0 212 212 1 1
AGER TIMP1 0 0 334 334 1 1
AGER SPOCK3 0 0 50 215 1 1
AGER PIGR 0 0 82 559 1 1
AGER EPHB2 0 0 352 363 1 2
AGER TNNI3 0 0 337 337 1 1
AGER CHUK 0 0 210 223 1 1
AGER PLA2G1B 0 0 205 205 1 1
AGER S100A12 213 600 989 996 1 1
AGER TLR5 0 0 309 309 1 1
AGER RHOA 270 0 459 588 1 2
AGER CDKN2A 0 0 151 150 1 2
AGER SOX8 0 0 0 167 1 1
AGER CXCL16 0 0 181 181 1 1
AGER GSR 0 0 219 219 1 1
AGER FABP4 0 0 134 197 1 1
AGER CSTF2 285 0 0 284 1 1
AGER TTR 413 0 955 972 1 1
AGER GSK3B 0 0 214 227 1 2
AGER MRC1 0 0 193 193 1 1
AGER ITGAX 0 0 234 234 1 1
AGER SFTPB 0 0 293 586 1 1
AGER SFTPA1 0 0 113 347 1 1
AGER SPP1 0 0 297 297 1 2
AGER FAT4 0 0 0 302 1 1
AGER S100B 955 600 989 999 1 1
AGER IGSF10 0 0 0 208 1 1
AGER FPR3 0 0 245 244 1 1
AGER FCGR2B 0 0 161 185 1 1
AGER NT5DC1 0 0 95 157 1 1
AGER GLI3 0 0 280 280 1 1
AGER RNF5 0 0 160 159 1 1
AGER CYBB 0 800 391 877 1 2
AGER ABCG1 0 0 150 150 1 2
AGER ANGPT1 0 0 242 241 1 1
AGER SIRT3 0 0 161 161 1 2
AGER GLO1 0 0 395 394 1 1
AGER CXCL5 0 0 182 199 1 1
AGER ARHGEF38 0 0 180 332 1 1
AGER MMP9 0 0 520 532 1 2
AGER MAPK3 0 600 667 861 1 2
AGER CD40 0 0 276 276 1 2
AGER ACE 0 0 425 424 1 1
AGER FPR2 0 0 452 452 1 1
AGER ALOX5 0 0 123 173 1 1
AGER ABCA7 0 0 187 236 1 1
AGER SELL 0 0 195 224 1 1
AGER REN 0 0 384 384 1 1
AGER INS 0 0 518 518 1 2
AGER SELP 0 0 370 383 1 1
AGER GAS6 0 0 210 210 1 1
AGER CLDN5 0 0 358 372 1 1
AGER IL13 0 0 338 338 1 2
AGER ACTB 0 0 402 402 1 2
AGER EMP2 0 0 181 181 1 1
AGER CRP 0 0 561 561 1 2
AGER ENPP1 0 0 166 165 1 1
AGER PSEN1 0 0 468 468 1 2
AGER TNFRSF21 0 0 309 309 1 1
AGER MSR1 0 0 325 325 1 1
AGER IL1RL1 0 0 165 165 1 1
AGER CCL11 0 0 234 234 1 1
AGER PTGS2 0 0 422 422 1 2
AGER CASP3 0 0 456 456 1 2
AGER F3 0 0 391 390 1 1
AGER TMEM38B 0 0 0 211 1 1
AGER TRPM2 0 0 171 270 1 2
AGER CXCL1 0 0 414 427 1 2
AGER IL33 0 0 341 341 1 2
AGER S100A11 0 0 832 832 1 1
AGER APCS 0 0 166 165 1 1
AGER MBL2 0 0 205 205 1 1
AGER CLEC14A 0 0 46 331 1 1
AGER NLRP3 0 0 460 459 1 2
AGER HSP90AA1 0 0 204 204 1 2
AGER REL 0 0 153 152 1 2
AGER MMP14 0 0 167 167 1 1
AGER SHROOM4 0 0 73 325 1 1
AGER JUN 0 0 405 405 1 2
AGER PGF 0 0 154 153 1 1
AGER LPCAT2 0 0 0 184 1 1
AGER CLIC5 0 0 150 215 1 1
AGER NOD1 0 0 195 226 1 2
AGER GP1BA 0 0 119 158 1 1
AGER TMEM173 0 0 73 185 1 1
AGER ITGAL 0 0 195 220 1 1
AGER CD86 0 0 242 268 1 1
AGER NPPB 0 0 154 153 1 1
AGER BGN 0 0 204 204 1 1
AGER KL 0 0 202 202 1 2
AGER SERPINA1 0 0 288 288 1 2
AGER ENSG00000173366 0 0 602 602 1 1
AGER LRP2 0 0 358 358 1 1
AGER ECE2 0 0 166 165 1 1
AGER IFITM5 0 0 0 213 1 1
AGER HLA-DRB1 0 0 149 169 1 1
AGER CAV1 0 0 260 260 1 2
AGER TLR2 0 0 804 809 1 2
AGER APH1A 0 0 294 307 1 1
AGER TNFSF10 0 0 163 163 1 2
AGER HSPA1A 0 0 266 266 1 1
AGER FGF23 0 0 181 181 1 1
AGER AIF1 0 0 390 411 1 2
AGER SRF 0 0 158 157 1 1
AGER CHRNA7 0 0 307 307 1 1
AGER SLC5A2 0 0 223 223 1 1
AGER PADI4 0 0 216 216 1 1
AGER GRIN2B 0 0 181 181 1 1
AGER THBS1 0 0 260 260 1 1
AGER ABCB1 0 0 218 218 1 2
AGER PTGES 0 0 180 179 1 1
AGER DNTT 0 0 156 155 1 1
AGER SDC1 0 0 216 216 1 1
AGER MAPT 0 0 323 323 1 2
AGER BECN1 0 0 370 370 1 2
AGER PLAT 0 0 234 234 1 1
AGER SNCA 0 0 267 267 1 2
AGER CASP1 0 0 458 474 1 2
AGER LRP1 0 0 683 683 1 1
AGER PRKCSH 0 0 458 469 1 1
AGER PSENEN 0 0 297 297 1 1
AGER TLR6 0 0 292 292 1 1
AGER IL2 0 0 289 288 1 1
AGER ANXA1 0 0 267 267 1 1
AGER OLR1 0 0 373 373 1 2
AGER ITGB2 0 900 381 939 1 1
AGER TAGLN2 0 0 101 169 1 1
AGER ANGPT2 0 0 390 390 1 1
AGER KRAS 270 800 218 875 1 2
AGER TFAM 0 0 715 720 1 2
AGER CHRNA5 0 0 242 241 1 1
AGER MMP2 0 0 391 390 1 2
AGER PTH 0 0 186 186 1 1
AGER RNASE3 0 0 154 153 1 1
AGER TREM2 0 0 341 341 1 1
AGER RBP4 0 0 349 349 1 1
AGER SOD2 0 0 162 161 1 2
AGER AZU1 0 0 229 228 1 1
AGER P2RY1 0 0 184 184 1 1
AGER ITGB1BP2 0 0 48 162 1 1
AGER ARMC2 0 0 294 370 1 1
AGER HAVCR2 0 0 269 269 1 1
AGER NRAS 0 800 0 800 1 1
AGER CD8A 0 0 341 341 1 1
AGER SORD 0 0 415 414 1 1
AGER CALR 0 0 301 301 1 1
AGER SAP25 0 0 0 172 1 1
AGER PICALM 0 0 282 282 1 1
AGER P2RY12 0 0 161 161 1 1
AGER CCR5 0 0 205 224 1 1
AGER AQP4 0 0 261 267 1 1
AGER GTPBP4 0 0 0 394 1 1
AGER SOD1 0 0 231 230 1 2
AGER PON1 0 0 170 195 1 1
AGER GRB2 338 0 74 360 1 1
AGER FASLG 0 0 180 179 1 1
AGER FOS 0 0 166 165 1 2
AGER TICAM1 0 0 134 161 1 2
AGER S100A8 0 0 625 635 1 2
AGER HMGB4 0 0 160 173 1 1
AGER FYN 0 0 141 178 1 1
AGER S100A13 800 0 671 931 1 1
AGER APLP1 0 0 306 306 1 1
AGER CA1 0 0 396 396 1 1
AGER AGPAT1 0 0 218 239 1 1
AGER P2RX7 0 0 391 390 1 2
AGER CTGF 0 0 244 243 1 1
AGER S100A4 417 0 975 985 1 1
AGER NKX2-1 0 0 171 215 1 1
AGER ADAM19 0 0 371 371 1 1
AGER HSPB1 0 0 204 204 1 2
AGER NCF2 0 0 142 174 1 1
AGER PTGER4 0 0 141 172 1 1
AGER CCR1 0 0 130 161 1 1
AGER HTR4 0 0 57 158 1 1
AGER PRNP 0 0 306 306 1 2
AGER STAB2 0 0 325 325 1 1
AGER TIMP2 0 0 171 171 1 1
AGER TNS1 0 0 249 265 1 1
AGER RIN3 0 0 208 247 1 1
AGER S100P 892 0 456 940 1 1
AGER HIST2H3PS2 0 0 156 155 1 1
AGER ADAM17 0 0 222 222 1 1
AGER ELANE 0 0 294 294 1 1
AGER PRKCA 0 0 171 171 1 1
AGER CD300LB 0 0 163 369 1 1
AGER PLD1 0 0 309 309 1 2
AGER CAPZA2 0 650 0 650 1 1
AGER VTN 0 0 270 270 1 1
AGER FN1 0 0 391 390 1 2
AGER ADIPOQ 0 0 390 390 1 2
AGER IKBKG 0 0 142 167 1 1
AGER C6orf10 0 0 161 161 1 1
AGER MMP13 0 0 325 325 1 2
AGER ARG1 0 0 320 319 1 2
AGER MAPK8 0 0 211 211 1 2
AGER SEC61B 270 0 0 270 1 1
AGER C3 0 0 248 265 1 2
AGER SPI1 0 0 90 162 1 1
AGER AKR1B1 0 0 466 465 1 1
AGER NOX1 0 800 245 842 1 1
AGER CTSB 0 0 297 297 1 2
AGER BAI1 0 0 289 288 1 1
AGER IL17A 0 0 391 390 1 2
AGER EGF 0 0 288 288 1 2
AGER PRTN3 0 0 218 218 1 1
AGER SIRT1 0 0 315 315 1 2
AGER MYOCD 0 0 201 201 1 1
AGER QRFPR 0 0 50 468 1 1
AGER SLC1A2 0 0 156 155 1 1
AGER CASP9 0 0 217 217 1 2
AGER BACE1 0 0 504 504 1 2
AGER TRAF6 0 0 273 273 1 2
AGER P2RY2 0 0 241 240 1 1
AGER ITGAM 0 900 392 939 1 1
AGER CYCS 0 0 268 268 1 2
AGER COL6A6 0 0 54 259 1 1
AGER NRP1 201 0 84 236 1 1
AGER BTNL2 0 0 169 169 1 1
AGER TLR7 0 0 369 369 1 2
AGER IFNB1 0 0 293 293 1 1
AGER MIER1 272 0 0 272 1 1
AGER HMGB1 698 900 989 999 1 2
AGER DUOX2 0 0 245 244 1 1
AGER HSPB3 0 0 156 155 1 1
AGER HSP90B1 0 0 162 161 1 1
AGER ATG5 0 0 212 212 1 2
AGER CCR2 0 0 325 342 1 2
AGER PPARA 0 0 207 207 1 2
AGER SYP 0 0 235 235 1 1
AGER TLR8 0 0 274 296 1 1
AGER ACHE 0 0 236 244 1 2
AGER TEK 0 0 216 216 1 1
AGER IL12B 0 0 46 301 1 1
AGER CXCL9 0 0 174 192 1 1
AGER HSPA4 0 0 483 483 1 1
AGER CXCR3 0 0 143 159 1 1
AGER SCARF1 0 0 204 204 1 1
AGER ELN 0 0 310 309 1 1
AGER CX3CR1 0 0 268 268 1 1
AGER ANXA3 0 0 125 165 1 1
AGER FPR1 0 0 392 392 1 1
AGER VEGFA 0 0 519 519 1 2
AGER ITGB1 128 0 101 182 1 1
AGER PTEN 0 0 170 169 1 2
AGER TYROBP 0 0 125 156 1 1
AGER MBP 0 0 211 211 1 2
AGER MME 0 0 392 392 1 1
AGER LEPR 0 0 181 181 1 1
AGER ALB 0 0 775 775 1 2
AGER CD68 0 0 369 369 1 2
AGER CASP8 0 0 195 195 1 2
AGER CD200 0 0 360 360 1 1
AGER KNG1 0 0 180 179 1 1
AGER CCL2 0 0 563 563 1 2
AGER RARB 0 0 181 181 1 1
AGER ROCK1 0 0 150 164 1 2
AGER ZBTB12 0 0 75 167 1 1
AGER LEP 0 0 325 325 1 1
AGER SYK 0 0 150 185 1 2
AGER TNXB 0 0 234 234 1 1
AGER NFKBIA 0 0 284 284 1 2
AGER SERPINF1 0 0 308 307 1 1
AGER CLEC4E 0 0 167 167 1 1
AGER SIRPA 0 0 172 171 1 1
AGER CDK5 0 0 211 211 1 2
AGER MEOX2 0 0 142 166 1 1
AGER MAPK14 0 0 204 204 1 2
AGER NGFR 0 0 156 155 1 1
AGER PBX2 0 0 442 475 1 1
AGER FCGR2A 0 0 183 183 1 1
AGER IL4 0 0 383 382 1 1
AGER SCARB1 0 0 374 390 1 1
AGER TYRO3 0 0 146 160 1 1
AGER SERPINC1 0 0 241 240 1 1
AGER PLG 0 0 364 364 1 1
AGER CTSD 0 0 156 155 1 2
AGER MARCO 0 0 301 318 1 1
AGER EZR 0 0 171 171 1 1
AGER MFGE8 0 0 262 262 1 1
AGER CD33 0 0 189 189 1 1
AGER PRKCZ 270 0 128 404 1 1
AGER THBD 0 0 403 403 1 1
AGER MB21D1 0 0 203 203 1 1
AGER CDH1 0 0 231 230 1 2
AGER PDPN 0 0 217 261 1 1
AGER ITGA2B 0 0 155 176 1 1
AGER SNAP47 0 0 180 179 1 1
AGER C10orf11 0 0 341 341 1 1
AGER ICAM3 0 0 141 172 1 1
AGER CCL3 0 0 336 336 1 1
AGER CTSG 0 0 234 234 1 1
AGER FCGR3B 0 0 159 178 1 1
AGER CCL22 0 0 167 167 1 1
AGER C4B 0 0 205 223 1 1
AGER SIRT6 0 0 149 170 1 2
AGER DDX58 0 0 315 315 1 1
AGER AIM2 0 0 370 370 1 2
AGER SELE 0 0 391 390 1 1
AGER TJP1 0 0 294 294 1 1
AGER CRYGC 0 0 207 207 1 1
AGER CCL4 0 0 243 242 1 1
AGER ATG7 0 0 154 153 1 2
AGER IL1A 0 0 395 394 1 1
AGER DLG4 0 0 205 205 1 2
AGER GDF15 0 0 193 193 1 1
AGER ABCA1 0 0 249 267 1 2
AGER OPRD1 0 0 330 330 1 1
AGER IAPP 0 0 290 290 1 2
AGER DPP4 0 0 180 179 1 1
AGER BCHE 0 0 164 173 1 1
AGER BSG 0 0 233 232 1 1
AGER GFAP 0 0 260 266 1 2
AGER JAM3 0 0 157 156 1 1
AGER IL10 0 0 504 504 1 2
AGER CCL20 0 0 181 181 1 1
AGER FMN1 0 0 635 635 1 1
AGER IRAK4 270 0 194 449 1 1
AGER CXCL2 0 0 248 264 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0044548 Molecular Function S100 protein binding enables IPI
GO:0050785 Molecular Function advanced glycation end-product receptor activity enables NAS
GO:0001540 Molecular Function amyloid-beta binding enables IDA
GO:0001540 Molecular Function amyloid-beta binding enables IPI
GO:0001540 Molecular Function amyloid-beta binding enables NAS
GO:0001540 Molecular Function amyloid-beta binding enables TAS
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0005055 Molecular Function laminin receptor activity enables IBA
GO:0060090 Molecular Function molecular adaptor activity enables EXP
GO:0005515 Molecular Function protein binding enables IPI
GO:0044877 Molecular Function protein-containing complex binding enables IPI
GO:0005044 Molecular Function scavenger receptor activity enables TAS
GO:0038023 Molecular Function signaling receptor activity enables IBA
GO:0038023 Molecular Function signaling receptor activity enables IMP
GO:0004888 Molecular Function transmembrane signaling receptor activity enables TAS
GO:0048143 Biological Process astrocyte activation involved_in IGI
GO:0007155 Biological Process cell adhesion involved_in IEA
GO:0007166 Biological Process cell surface receptor signaling pathway involved_in TAS
GO:1904646 Biological Process cellular response to amyloid-beta involved_in ISS
GO:0006897 Biological Process endocytosis involved_in IEA
GO:0010255 Biological Process glucose mediated signaling pathway involved_in IDA
GO:0050930 Biological Process induction of positive chemotaxis involved_in IEA
GO:0006954 Biological Process inflammatory response involved_in TAS
GO:0007611 Biological Process learning or memory involved_in IGI
GO:0001774 Biological Process microglial cell activation involved_in IGI
GO:0001774 Biological Process microglial cell activation involved_in ISS
GO:1903523 Biological Process negative regulation of blood circulation involved_in ISS
GO:0032693 Biological Process negative regulation of interleukin-10 production involved_in IDA
GO:1900453 Biological Process negative regulation of long-term synaptic depression involved_in IGI
GO:1900272 Biological Process negative regulation of long-term synaptic potentiation involved_in IGI
GO:1900272 Biological Process negative regulation of long-term synaptic potentiation involved_in ISS
GO:0031175 Biological Process neuron projection development involved_in IGI
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IGI
GO:0046330 Biological Process positive regulation of JNK cascade involved_in IGI
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
GO:0042104 Biological Process positive regulation of activated T cell proliferation involved_in IMP
GO:1902961 Biological Process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process involved_in IGI
GO:0032722 Biological Process positive regulation of chemokine production involved_in ISS
GO:2001200 Biological Process positive regulation of dendritic cell differentiation involved_in IMP
GO:1904472 Biological Process positive regulation of endothelin production involved_in ISS
GO:0034116 Biological Process positive regulation of heterotypic cell-cell adhesion involved_in IGI
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in ISS
GO:0032735 Biological Process positive regulation of interleukin-12 production involved_in IMP
GO:0032755 Biological Process positive regulation of interleukin-6 production involved_in ISS
GO:0071639 Biological Process positive regulation of monocyte chemotactic protein-1 production involved_in IEA
GO:2000439 Biological Process positive regulation of monocyte extravasation involved_in IMP
GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in IGI
GO:1900745 Biological Process positive regulation of p38MAPK cascade involved_in IGI
GO:0001934 Biological Process positive regulation of protein phosphorylation involved_in IGI
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in ISS
GO:0072657 Biological Process protein localization to membrane involved_in IEA
GO:2000514 Biological Process regulation of CD4-positive, alpha-beta T cell activation involved_in IDA
GO:0001914 Biological Process regulation of T cell mediated cytotoxicity involved_in IDA
GO:0050727 Biological Process regulation of inflammatory response involved_in IBA
GO:1900271 Biological Process regulation of long-term synaptic potentiation involved_in ISS
GO:1901222 Biological Process regulation of non-canonical NF-kappaB signal transduction involved_in NAS
GO:1900744 Biological Process regulation of p38MAPK cascade involved_in IBA
GO:1900744 Biological Process regulation of p38MAPK cascade involved_in ISS
GO:0150003 Biological Process regulation of spontaneous synaptic transmission involved_in IGI
GO:0048167 Biological Process regulation of synaptic plasticity involved_in TAS
GO:1904645 Biological Process response to amyloid-beta involved_in ISS
GO:1904645 Biological Process response to amyloid-beta involved_in TAS
GO:0001666 Biological Process response to hypoxia involved_in IEA
GO:0009611 Biological Process response to wounding involved_in TAS
GO:0045056 Biological Process transcytosis involved_in ISS
GO:0150104 Biological Process transport across blood-brain barrier involved_in IDA
GO:0150104 Biological Process transport across blood-brain barrier involved_in NAS
GO:0016324 Cellular Component apical plasma membrane located_in IDA
GO:0030054 Cellular Component cell junction located_in IDA
GO:0009986 Cellular Component cell surface located_in NAS
GO:0005576 Cellular Component extracellular region located_in IEA
GO:0001650 Cellular Component fibrillar center located_in IDA
GO:0005886 Cellular Component plasma membrane is_active_in IBA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in NAS
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0098794 Cellular Component postsynapse located_in TAS
Pathways
Name DB ID
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Reactome R-HSA-166058
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
Toll Like Receptor 10 (TLR10) Cascade Reactome R-HSA-168142
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade Reactome R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade Reactome R-HSA-168179
Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade Reactome R-HSA-168188
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
DDX58/IFIH1-mediated induction of interferon-alpha/beta Reactome R-HSA-168928
Toll Like Receptor 2 (TLR2) Cascade Reactome R-HSA-181438
TAK1-dependent IKK and NF-kappa-B activation Reactome R-HSA-445989
Interleukin-1 family signaling Reactome R-HSA-446652
Signaling by Interleukins Reactome R-HSA-449147
Advanced glycosylation endproduct receptor signaling Reactome R-HSA-879415
Interleukin-1 signaling Reactome R-HSA-9020702
TRAF6 mediated NF-kB activation Reactome R-HSA-933542
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome R-HSA-975138
MyD88 dependent cascade initiated on endosome Reactome R-HSA-975155
MyD88 cascade initiated on plasma membrane Reactome R-HSA-975871
Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
Chronic hyperglycemia impairment of neuron function (WP5283) WikiPathways WP5283_r124551
Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
Nuclear receptors meta-pathway (WP2882) WikiPathways WP2882_r120815
NRF2 pathway (WP2884) WikiPathways WP2884_r106658
LTF danger signal response pathway (WP4478) WikiPathways WP4478_r121699
Supression of HMGB1 mediated inflammation by THBD (WP4479) WikiPathways WP4479_r121700
AGE/RAGE pathway (WP2324) WikiPathways WP2324_r120674
Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_038190 2 miscRNA transcript variant 10 NC_000006 Reference
NM_001206932 2 mRNA transcript variant 3 NC_000006 Reference
NM_172197 3 mRNA transcript variant 7 NC_000006 Reference
NM_001206954 2 mRNA transcript variant 8 NC_000006 Reference
NM_001206936 2 mRNA transcript variant 5 NC_000006 Reference
NM_001136 5 mRNA transcript variant 1 NC_000006 Reference
NM_001206966 2 mRNA transcript variant 9 NC_000006 Reference
NM_001206940 2 mRNA transcript variant 6 NC_000006 Reference
XM_017010328 3 mRNA transcript variant X1 NC_000006 Reference
NM_001206929 2 mRNA transcript variant 2 NC_000006 Reference
NM_001206934 2 mRNA transcript variant 4 NC_000006 Reference
XM_047418261 1 mRNA transcript variant X3 NC_000006 Reference
XM_047418260 1 mRNA transcript variant X2 NC_000006 Reference