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MLKL

mixed lineage kinase domain like pseudokinase
General Information
Name mixed lineage kinase domain like pseudokinase
Alias
  • mixed lineage kinase domain-like protein
Gene_family
organism Homo sapiens
entrez_id 197259
location 16q23.1
transcript_count 11
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
    Stringdb Mixed lineage kinase domain-like protein; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity
    nextProt Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
MLKL BioGRID STT3B GeneID BioGRID Affinity Capture-MS
MLKL BioGRID SLC30A6 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID RETSAT GeneID BioGRID Affinity Capture-MS
MLKL BioGRID MRFAP1L1 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID OBSCN GeneID BioGRID Affinity Capture-MS
MLKL BioGRID PRKCZ GeneID BioGRID Affinity Capture-MS
MLKL BioGRID IMPDH2 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID EXO1 GeneID BioGRID Negative Genetic
MLKL BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID STAMBP GeneID BioGRID Biochemical Activity
MLKL BioGRID USP2 GeneID BioGRID Biochemical Activity
MLKL BioGRID TSG101 GeneID BioGRID Affinity Capture-Western
MLKL BioGRID CYLD GeneID BioGRID Biochemical Activity
MLKL BioGRID MVB12B GeneID BioGRID Affinity Capture-Western
MLKL BioGRID ITCH GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MLKL BioGRID VPS28 GeneID BioGRID Affinity Capture-Western
MLKL BioGRID RIPK3 GeneID BioGRID Affinity Capture-Western
MLKL BioGRID TNF GeneID BioGRID Affinity Capture-MS
MLKL BioGRID TRIM33 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID CECR2 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID BRD1 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID ZMYND8 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID BRD4 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID TRIM66 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID TRIM24 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID SP100 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID BRD2 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID SP110 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID S100A10 GeneID BioGRID Two-hybrid
MLKL BioGRID PSMB1 GeneID BioGRID Two-hybrid
MLKL BioGRID AAR2 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID EFTUD2 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID RIPK1 GeneID BioGRID Affinity Capture-Western
MLKL BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
MLKL BioGRID SNW1 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID LRCH3 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID PARP16 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID ZNF281 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID SRA1 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID GLG1 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID CASP8 GeneID BioGRID Affinity Capture-MS
MLKL BioGRID THOC3 GeneID BioGRID Two-hybrid
MLKL BioGRID RAD18 GeneID BioGRID Two-hybrid
MLKL BioGRID ANAPC11 GeneID BioGRID Two-hybrid
MLKL BioGRID NDUFB7 GeneID BioGRID Two-hybrid
MLKL BioGRID CDK1 GeneID BioGRID Two-hybrid
MLKL BioGRID PITPNA GeneID BioGRID Affinity Capture-MS
StringDB
A B experiments database textmining combined score hadb nhadb
MLKL USP18 0 0 122 194 1 1
MLKL ANO6 0 0 194 210 1 1
MLKL DFFB 0 0 212 212 1 1
MLKL MAMDC4 0 0 0 190 1 1
MLKL ISG15 0 0 66 157 1 2
MLKL NEK2 0 0 0 150 1 1
MLKL MAP3K12 0 0 530 304 1 1
MLKL RPS6KA1 0 0 0 155 1 1
MLKL CHMP6 0 600 0 608 1 1
MLKL IKBKG 0 0 459 470 1 1
MLKL PARD6B 0 0 0 189 1 1
MLKL DEDD2 0 0 149 180 1 1
MLKL DPM1 0 0 0 153 1 1
MLKL NOX1 0 0 166 229 1 1
MLKL CTSB 0 0 203 217 1 2
MLKL MCL1 0 0 282 298 1 2
MLKL SIRT1 0 0 136 155 1 2
MLKL GNA11 0 0 47 164 1 1
MLKL ITGAM 0 0 242 290 1 1
MLKL MAP3K5 0 0 289 387 1 1
MLKL MAPK6 0 0 0 184 1 1
MLKL HMGB1 0 0 498 506 1 2
MLKL HOXB8 0 0 108 182 1 1
MLKL WNT3A 0 0 0 158 1 2
MLKL ATG5 0 0 335 348 1 2
MLKL TLR8 0 0 92 168 1 1
MLKL XBP1 0 0 125 226 1 2
MLKL STAT2 0 0 139 262 1 1
MLKL ZNF281 246 0 0 277 1 1
MLKL STXBP5L 0 0 0 158 1 1
MLKL MAPK7 0 0 0 185 1 1
MLKL PTEN 0 0 376 426 1 2
MLKL RPS6KL1 0 0 0 155 1 1
MLKL SLC7A7 0 0 0 150 1 1
MLKL CASP5 0 0 235 399 1 1
MLKL DNM1L 0 0 587 602 1 2
MLKL TRAF7 0 0 66 195 1 1
MLKL PRKAA2 0 0 0 162 1 2
MLKL CLIC4 0 0 0 150 1 1
MLKL ATAD2B 0 0 0 170 1 1
MLKL RHOT2 0 0 0 179 1 1
MLKL NFKBIA 0 0 324 393 1 2
MLKL PARP16 198 0 0 213 1 1
MLKL MAPK14 0 0 96 278 1 2
MLKL CSF3R 0 0 0 161 1 1
MLKL MAPK10 0 0 108 208 1 2
MLKL CTSD 0 0 134 258 1 2
MLKL PLEKHG4B 0 0 0 184 1 1
MLKL EZR 0 0 0 155 1 1
MLKL TUBGCP2 0 0 0 161 1 1
MLKL ENSG00000267261 0 0 0 178 1 1
MLKL GNAI1 0 0 0 177 1 1
MLKL ATG7 0 0 321 360 1 2
MLKL CMPK2 0 0 61 174 1 1
MLKL SP110 154 0 0 264 1 1
MLKL EFNB2 0 0 0 168 1 1
MLKL FMN1 0 0 0 175 1 1
MLKL LRCH3 211 0 0 250 1 1
MLKL RBPJ 0 0 0 202 1 1
MLKL CXCL2 0 0 155 259 1 1
MLKL YWHAH 0 0 0 165 1 1
MLKL PHB2 0 0 59 156 1 1
MLKL EGFLAM 0 0 0 155 1 1
MLKL CSF1 0 0 119 167 1 1
MLKL ZNF320 0 0 123 159 1 1
MLKL PI4KA 0 0 0 165 1 1
MLKL UBE2L6 0 0 48 169 1 1
MLKL WNT2 0 0 0 183 1 1
MLKL CUL3 0 0 136 231 1 2
MLKL CHUK 0 0 349 349 1 1
MLKL SFN 0 0 0 165 1 2
MLKL CASP4 0 0 203 401 1 2
MLKL ITGAX 0 0 127 188 1 1
MLKL SLC11A1 0 0 0 208 1 1
MLKL PPIA 0 0 138 158 1 1
MLKL HSPA4L 0 0 0 166 1 1
MLKL ATG12 0 0 213 225 1 2
MLKL TNFRSF21 0 0 244 243 1 1
MLKL DAXX 0 0 97 187 1 1
MLKL TUBE1 0 0 134 194 1 1
MLKL TRIB3 0 0 81 197 1 2
MLKL CXCL1 0 0 260 356 1 2
MLKL IL33 0 0 310 309 1 2
MLKL GNA15 0 0 52 193 1 1
MLKL HSPA1B 0 0 52 196 1 1
MLKL LNX1 0 0 0 200 1 1
MLKL RPS6KC1 0 0 0 204 1 1
MLKL SHARPIN 0 0 469 497 1 1
MLKL GRID2 0 0 0 150 1 2
MLKL MALRD1 0 0 0 190 1 1
MLKL GNAI3 0 0 0 177 1 2
MLKL UGP2 0 0 0 162 1 1
MLKL CLIC1 0 0 0 154 1 1
MLKL CD86 0 0 123 172 1 1
MLKL ANKRD45 0 0 0 175 1 1
MLKL PIM3 0 0 0 191 1 1
MLKL PMAIP1 0 0 205 205 1 2
MLKL TLR2 0 0 284 363 1 2
MLKL LRRK2 0 0 96 174 1 2
MLKL GNAO1 0 0 0 177 1 1
MLKL MET 0 0 0 180 1 2
MLKL TRAF3 0 0 195 265 1 2
MLKL ARL4C 0 0 61 179 1 1
MLKL EIF4EBP2 0 0 0 278 1 1
MLKL DUSP3 0 0 53 155 1 1
MLKL FOXO1 0 0 81 154 1 2
MLKL SMIM12 0 0 194 194 1 1
MLKL CHMP5 0 600 0 621 1 1
MLKL NRAS 0 0 44 151 1 1
MLKL HSPA5 0 0 161 278 1 2
MLKL MYO3B 0 0 0 155 1 1
MLKL IRG1 0 0 124 220 1 1
MLKL PPM1N 0 0 0 198 1 1
MLKL YWHAZ 0 0 0 165 1 1
MLKL AIFM3 0 0 66 287 1 1
MLKL PINK1 0 0 286 316 1 2
MLKL GPT 0 0 228 257 1 1
MLKL MYOF 0 0 298 313 1 1
MLKL CYLD 0 0 681 690 1 1
MLKL ADRM1 0 0 0 156 1 1
MLKL HSP90AB1 0 800 0 840 1 2
MLKL GRIK4 0 0 0 150 1 1
MLKL AIFM1 0 0 128 308 1 1
MLKL RNF213 0 0 61 191 1 1
MLKL DENR 0 0 242 270 1 1
MLKL PPM1E 0 0 0 198 1 1
MLKL CSF2 0 0 202 202 1 1
MLKL EFNB3 0 0 0 168 1 1
MLKL GRIK1 0 0 0 150 1 1
MLKL WDTC1 0 0 0 164 1 1
MLKL IFIT3 0 0 90 278 1 1
MLKL MAP3K15 0 0 0 173 1 1
MLKL FAS 0 0 394 419 1 2
MLKL SKI 0 0 86 157 1 1
MLKL NLRC4 0 0 373 403 1 2
MLKL ATP7A 0 0 0 152 1 1
MLKL PARL 0 0 123 247 1 1
MLKL SBK3 0 0 264 264 1 1
MLKL TBK1 0 0 260 178 1 2
MLKL CORO2A 0 0 0 162 1 1
MLKL PTPN6 0 0 67 174 1 1
MLKL IL4I1 0 0 0 511 1 1
MLKL PARD6G 0 0 0 189 1 1
MLKL RAC2 0 0 0 189 1 1
MLKL LRIT3 0 0 0 165 1 1
MLKL STAT5B 0 0 62 164 1 1
MLKL RAB7B 0 0 95 150 1 1
MLKL VDAC1 0 0 159 175 1 2
MLKL TGFB1 0 0 57 184 1 2
MLKL GLUL 0 0 241 266 1 1
MLKL ALG2 0 0 0 157 1 1
MLKL PRKCD 0 0 82 175 1 2
MLKL MAP3K6 0 0 0 173 1 1
MLKL RIPK3 870 800 990 989 1 2
MLKL FMNL1 0 0 0 163 1 1
MLKL FOXO3 0 0 109 180 1 2
MLKL CDC42 0 0 74 169 1 2
MLKL UAP1L1 0 0 0 169 1 1
MLKL ARHGAP27 0 0 0 157 1 1
MLKL TLR3 0 0 507 542 1 2
MLKL ANKRD17 0 0 67 175 1 1
MLKL ACSM2A 0 0 0 210 1 1
MLKL BIRC6 0 0 124 238 1 1
MLKL CORO1A 0 0 0 162 1 1
MLKL RSAD2 0 0 84 205 1 1
MLKL SLC30A8 0 0 0 176 1 1
MLKL ATG3 0 0 150 218 1 2
MLKL CHMP4B 0 600 181 671 1 2
MLKL PPP2CA 0 0 0 160 1 1
MLKL YWHAQ 0 0 0 165 1 1
MLKL RRAD 0 0 0 176 1 1
MLKL IPMK 0 0 206 221 1 1
MLKL IFT43 0 0 156 155 1 1
MLKL IFIT2 0 0 59 187 1 1
MLKL VPS37B 0 0 152 151 1 1
MLKL PPM1K 0 0 0 198 1 1
MLKL PRKAA1 0 0 0 162 1 2
MLKL LRGUK 0 0 0 161 1 1
MLKL UAP1 0 0 0 169 1 1
MLKL EFNA1 0 0 0 168 1 1
MLKL LPCAT3 0 0 154 153 1 1
MLKL DFFA 0 0 139 162 1 1
MLKL PHLPP2 0 0 0 162 1 1
MLKL MAP2K2 0 0 0 185 1 1
MLKL PPP2R5E 0 0 0 170 1 1
MLKL EVL 0 0 0 158 1 1
MLKL GRIK5 0 0 0 150 1 1
MLKL INADL 0 0 0 159 1 1
MLKL ENSG00000258973 0 0 0 424 1 1
MLKL S100A10 282 0 0 296 1 1
MLKL NUBP2 0 0 154 183 1 1
MLKL TXN 0 0 124 177 1 1
MLKL LCP1 0 0 0 159 1 1
MLKL CENPK 0 0 0 157 1 1
MLKL TSSK2 0 0 0 158 1 1
MLKL TIRAP 0 0 134 185 1 1
MLKL HSPA2 0 0 47 151 1 1
MLKL SDK2 0 0 0 171 1 1
MLKL TANK 0 0 112 186 1 2
MLKL GNAI2 0 0 0 177 1 1
MLKL CASP2 0 0 304 322 1 1
MLKL ATP11C 0 0 134 169 1 1
MLKL CHMP2A 0 600 165 666 1 1
MLKL HERC6 0 0 0 153 1 1
MLKL ABI2 0 0 0 150 1 1
MLKL VCL 0 0 107 162 1 1
MLKL TSSK1B 0 0 0 158 1 1
MLKL DFNB59 0 0 181 181 1 1
MLKL PPTC7 0 0 0 198 1 1
MLKL IREB2 0 0 181 218 1 1
MLKL IFNAR1 0 0 323 365 1 1
MLKL BCL2A1 0 0 82 212 1 1
MLKL CDK17 0 0 74 158 1 1
MLKL RELB 0 0 171 189 1 2
MLKL PPP2R5C 0 0 0 150 1 1
MLKL CCT2 0 0 81 194 1 1
MLKL EFNA3 0 0 0 168 1 1
MLKL MAPK1 0 0 66 208 1 2
MLKL P2RX7 0 0 166 165 1 2
MLKL PPP2CB 0 0 0 151 1 1
MLKL CHKA 0 0 0 159 1 1
MLKL GPX4 0 0 451 463 1 2
MLKL DIABLO 0 0 681 691 1 2
MLKL SPATA2 0 0 211 211 1 1
MLKL CLIC2 0 0 0 150 1 1
MLKL MAP2K4 0 0 145 160 1 1
MLKL MAPK8 0 0 256 339 1 2
MLKL GNAZ 0 0 0 177 1 1
MLKL PCSK1 0 0 825 837 1 1
MLKL PELI1 0 0 151 188 1 1
MLKL GAK 0 0 0 176 1 1
MLKL TRAF6 0 0 163 236 1 2
MLKL COLGALT1 0 0 181 181 1 1
MLKL PDP1 0 0 0 201 1 1
MLKL DHX36 0 0 0 185 1 1
MLKL NWD2 0 0 125 158 1 1
MLKL PPM1L 0 0 0 198 1 1
MLKL CYCS 0 0 469 469 1 2
MLKL CYP2E1 0 0 157 170 1 2
MLKL HSP90B1 0 0 48 255 1 1
MLKL PDZD2 0 0 0 159 1 1
MLKL HSPA4 0 0 278 349 1 1
MLKL CASP7 0 0 375 403 1 1
MLKL CSNK1D 0 0 0 164 1 1
MLKL IFI6 0 0 65 275 1 1
MLKL OTULIN 0 0 260 260 1 1
MLKL CDC37 0 600 261 727 1 1
MLKL CCL2 0 0 260 276 1 2
MLKL ALB 0 0 244 257 1 2
MLKL CD68 0 0 124 198 1 2
MLKL BPGM 0 0 0 151 1 1
MLKL BIRC3 0 0 422 606 1 1
MLKL ANXA8 0 0 167 167 1 1
MLKL NUMB 0 0 0 159 1 1
MLKL RAP1B 0 0 0 159 1 1
MLKL VPS35 0 0 0 171 1 2
MLKL MB21D1 0 0 275 313 1 1
MLKL AGER 0 0 182 195 1 2
MLKL SGK494 0 0 0 205 1 1
MLKL ECD 0 0 103 151 1 2
MLKL ALK 0 0 0 177 1 2
MLKL TRADD 0 0 687 707 1 1
MLKL IGDCC3 0 0 0 184 1 1
MLKL RHBDF2 0 0 51 152 1 1
MLKL NFS1 0 0 48 164 1 1
MLKL RNF8 0 0 0 239 1 1
MLKL XKR8 0 0 234 301 1 1
MLKL PTPRC 0 0 184 262 1 1
MLKL HUNK 0 0 0 235 1 1
MLKL BCL10 0 0 108 154 1 1
MLKL BAX 0 0 260 260 1 2
MLKL GNA12 0 0 0 177 1 1
MLKL N4BP1 0 0 73 152 1 1
MLKL BID 0 0 243 259 1 2
MLKL SLC11A2 0 0 0 182 1 1
MLKL BNIP3 0 0 170 188 1 2
MLKL SQSTM1 0 0 324 368 1 2
MLKL MAPK3 0 0 151 277 1 2
MLKL ULK4 0 0 113 258 1 1
MLKL GRAP2 0 0 0 170 1 1
MLKL NLRX1 0 0 66 209 1 2
MLKL GNA14 0 0 0 158 1 1
MLKL ATG13 0 0 140 158 1 2
MLKL SP100 154 0 0 251 1 1
MLKL HSP90AA1 0 800 521 914 1 2
MLKL ETNK2 0 0 0 167 1 1
MLKL DHX15 0 0 0 232 1 1
MLKL JUN 0 0 287 314 1 2
MLKL CTDSP2 0 0 57 159 1 1
MLKL CLIC5 0 0 0 150 1 1
MLKL GLG1 151 0 91 207 1 1
MLKL TRIO 0 0 0 172 1 1
MLKL ENSG00000173366 0 0 213 263 1 1
MLKL DIDO1 0 0 0 182 1 1
MLKL CORO2B 0 0 0 162 1 1
MLKL AIF1 0 0 194 246 1 2
MLKL PADI4 0 0 261 282 1 1
MLKL STXBP5 0 0 0 158 1 1
MLKL PIK3CG 0 0 0 155 1 1
MLKL MYO3A 0 0 0 155 1 1
MLKL DNTT 0 0 233 232 1 1
MLKL PPM1F 0 0 0 201 1 1
MLKL CSNK1G2 0 0 82 181 1 1
MLKL EIF2AK2 0 0 119 173 1 2
MLKL MFN1 0 0 134 229 1 2
MLKL SRA1 198 0 0 291 1 1
MLKL CLIP4 0 0 0 163 1 1
MLKL SOD1 0 0 180 223 1 2
MLKL LTA 0 0 69 151 1 1
MLKL ANKRD44 0 0 0 160 1 1
MLKL LRIT1 0 0 0 165 1 1
MLKL ABI1 0 0 0 150 1 1
MLKL GRB2 0 0 0 170 1 1
MLKL EYS 0 0 0 181 1 1
MLKL PP2D1 0 0 0 198 1 1
MLKL APC 0 0 0 151 1 1
MLKL EFNB1 0 0 0 168 1 1
MLKL GSDMD 0 0 686 704 1 2
MLKL PPID 0 0 252 270 1 1
MLKL GDF9 0 0 45 153 1 1
MLKL GRIK2 0 0 0 150 1 1
MLKL GRID2IP 0 0 0 260 1 1
MLKL MAP1LC3B2 0 0 0 341 1 1
MLKL EVPL 0 0 0 240 1 1
MLKL RELA 0 0 161 192 1 2
MLKL NABP1 0 0 125 167 1 1
MLKL TLR10 0 0 61 188 1 1
MLKL CASP6 0 0 234 251 1 1
MLKL STAT4 0 0 0 160 1 1
MLKL MAP2K7 0 0 156 171 1 1
MLKL TSSK3 0 0 0 162 1 1
MLKL GAPDH 0 0 408 433 1 2
MLKL ALG1L 0 0 0 157 1 1
MLKL CXCL8 0 0 219 300 1 2
MLKL POLR2C 0 0 0 154 1 1
MLKL FOLR2 0 0 0 151 1 1
MLKL STKLD1 0 0 194 212 1 1
MLKL VRK1 0 0 0 164 1 1
MLKL PASK 0 0 0 162 1 1
MLKL WNT2B 0 0 0 183 1 1
MLKL ALG1 0 0 0 157 1 1
MLKL SMC2 0 0 0 150 1 1
MLKL IGSF9B 0 0 0 156 1 1
MLKL CTNNB1 0 0 107 228 1 2
MLKL HRAS 0 0 141 259 1 2
MLKL ARL8A 0 0 0 151 1 1
MLKL MFN2 0 0 96 164 1 2
MLKL DCAF6 0 0 0 164 1 1
MLKL RANBP17 0 0 0 165 1 1
MLKL MTOR 0 0 170 249 1 2
MLKL TRIB2 0 0 72 189 1 1
MLKL DOHH 0 0 0 161 1 1
MLKL ENDOG 0 0 261 261 1 1
MLKL STAT1 0 0 232 366 1 2
MLKL PIK3C3 0 0 195 341 1 2
MLKL GNA13 0 0 0 177 1 1
MLKL LAMP1 0 0 134 165 1 2
MLKL ANKFY1 0 0 0 156 1 1
MLKL CFLAR 0 0 654 674 1 2
MLKL MAP3K13 0 0 556 316 1 1
MLKL LCN2 0 0 123 156 1 1
MLKL TP53 0 0 294 305 1 2
MLKL TIMM50 0 0 61 156 1 1
MLKL MAP3K7 0 0 326 153 1 2
MLKL SLC7A5 0 0 57 230 1 1
MLKL EDA 0 0 0 295 1 1
MLKL ZBP1 0 0 564 651 1 1
MLKL MAP1A 0 0 178 287 1 2
MLKL VPS4B 0 600 89 625 1 1
MLKL RBPMS2 0 0 91 153 1 1
MLKL CARD9 0 0 112 167 1 1
MLKL VRK3 0 0 230 328 1 1
MLKL MLIP 0 0 92 181 1 1
MLKL FHOD1 0 0 0 163 1 1
MLKL MELK 0 0 0 162 1 1
MLKL SENP5 0 0 0 177 1 1
MLKL BRD4 154 0 87 279 1 2
MLKL STMN4 0 0 0 150 1 1
MLKL TP53RK 0 0 0 210 1 1
MLKL NLRC5 0 0 106 187 1 1
MLKL C19orf24 0 0 158 269 1 1
MLKL APAF1 0 0 406 450 1 2
MLKL GNAT1 0 0 0 177 1 1
MLKL ETNK1 0 0 64 194 1 1
MLKL RHBDL3 0 0 0 166 1 1
MLKL FHOD3 0 0 0 163 1 1
MLKL UACA 0 0 73 183 1 1
MLKL FA2H 0 0 235 675 1 1
MLKL ABI3 0 0 0 150 1 1
MLKL TRIM33 154 0 0 168 1 1
MLKL ADAM10 0 0 205 205 1 1
MLKL PPP5C 0 0 107 195 1 1
MLKL PLCL1 0 0 0 236 1 1
MLKL CBLB 0 0 0 203 1 1
MLKL UCK2 0 0 0 171 1 1
MLKL APC2 0 0 0 151 1 1
MLKL IFNA1 0 0 208 208 1 1
MLKL PARK2 0 0 127 181 1 1
MLKL ILK 0 0 123 151 1 1
MLKL MEFV 0 0 391 423 1 1
MLKL PIM1 0 0 0 213 1 1
MLKL WDR64 0 0 0 176 1 1
MLKL GNAQ 0 0 0 158 1 1
MLKL CASP10 0 0 334 593 1 1
MLKL TNFRSF12A 0 0 159 177 1 1
MLKL SLC26A9 0 0 122 158 1 1
MLKL ACSM2B 0 0 92 252 1 1
MLKL STK11 0 0 60 165 1 2
MLKL CHAC1 0 0 161 163 1 1
MLKL OASL 0 0 0 225 1 1
MLKL ALG11 0 0 0 157 1 1
MLKL RB1CC1 0 0 193 193 1 2
MLKL MST1R 0 0 0 181 1 1
MLKL NCF2 0 0 53 166 1 1
MLKL MAP1LC3B 0 0 282 506 1 2
MLKL PIGA 0 0 0 157 1 1
MLKL EIF2A 0 0 57 600 1 2
MLKL EFNA2 0 0 0 168 1 1
MLKL ELANE 0 0 209 221 1 1
MLKL RIPK4 0 0 154 162 1 1
MLKL SPRED2 0 0 0 158 1 2
MLKL SENP3 0 0 66 194 1 1
MLKL PDK4 0 0 0 197 1 1
MLKL OPTN 0 0 265 277 1 2
MLKL UBQLN2 0 0 0 153 1 2
MLKL PIM2 0 0 0 162 1 1
MLKL CHKB 0 0 0 159 1 1
MLKL IFNB1 0 0 404 404 1 1
MLKL DFNA5 0 0 459 459 1 1
MLKL ILKAP 0 0 0 199 1 1
MLKL MIB1 0 0 0 188 1 1
MLKL IRF1 0 0 180 257 1 2
MLKL ACSL4 0 0 290 317 1 1
MLKL STK40 0 0 62 181 1 1
MLKL FPR1 0 0 122 184 1 1
MLKL NLRP6 0 0 173 193 1 1
MLKL DSTYK 0 0 153 152 1 1
MLKL SLC9C2 0 0 0 175 1 1
MLKL NME8 0 0 0 180 1 1
MLKL AASDHPPT 0 0 178 177 1 1
MLKL AMBRA1 0 0 93 150 1 2
MLKL ACER1 0 0 64 208 1 1
MLKL NLK 0 0 0 183 1 1
MLKL FAM20A 0 0 160 159 1 1
MLKL RFWD3 0 0 179 179 1 1
MLKL CLEC4E 0 0 202 253 1 1
MLKL CORO1B 0 0 0 162 1 1
MLKL TSSK6 0 0 0 158 1 1
MLKL CECR2 129 0 0 206 1 1
MLKL ATP7B 0 0 0 152 1 1
MLKL COPS7A 0 0 61 150 1 1
MLKL FCGR3B 0 0 81 154 1 1
MLKL RBM6 0 0 416 416 1 1
MLKL IL10 0 0 194 209 1 2
MLKL UBASH3A 0 0 90 166 1 1
MLKL FLT3 0 0 105 180 1 2
MLKL RIPK1 270 650 988 844 1 2
MLKL NOD2 0 0 194 229 1 2
MLKL PIK3CD 0 0 0 150 1 1
MLKL SMPD1 0 0 202 214 1 1
MLKL ATG16L1 0 0 189 189 1 2
MLKL INSRR 0 0 0 186 1 1
MLKL PPP6C 0 0 108 190 1 1
MLKL GSK3B 0 0 96 199 1 2
MLKL CYBB 0 0 180 254 1 2
MLKL MAPK15 0 0 0 184 1 1
MLKL OMA1 0 0 57 233 1 1
MLKL CTSS 0 0 48 167 1 1
MLKL PPM1B 0 0 391 490 1 1
MLKL TNFRSF10B 0 0 323 337 1 2
MLKL LTK 0 0 0 177 1 1
MLKL CASP3 0 0 633 659 1 2
MLKL RASGRP4 0 0 0 153 1 1
MLKL PTGS2 0 0 116 196 1 2
MLKL CARD16 0 0 0 170 1 1
MLKL NCAPH 0 0 0 188 1 1
MLKL NLRP3 0 800 650 932 1 2
MLKL REL 0 0 137 207 1 2
MLKL ZMYND8 154 0 0 168 1 1
MLKL ENSG00000251246 0 0 0 168 1 1
MLKL SGK223 0 0 150 173 1 1
MLKL MAPK11 0 0 0 184 1 1
MLKL DUSP1 0 0 57 158 1 1
MLKL NCAPD2 0 0 0 180 1 1
MLKL DNAJC10 0 0 0 166 1 1
MLKL AMH 0 0 0 188 1 1
MLKL HSH2D 0 0 171 211 1 1
MLKL PPM1A 0 0 73 225 1 1
MLKL BECN1 0 0 369 390 1 2
MLKL EEF1G 0 0 0 195 1 1
MLKL FBXL19 0 0 0 194 1 1
MLKL KANK2 0 0 405 454 1 1
MLKL TLR6 0 0 74 240 1 1
MLKL GYS1 0 0 0 157 1 1
MLKL ANXA1 0 0 134 196 1 1
MLKL SNRNP200 0 0 0 237 1 1
MLKL PKN2 0 0 93 185 1 1
MLKL KRAS 0 0 101 218 1 2
MLKL TSSK4 0 0 42 163 1 1
MLKL CORO1C 0 0 0 162 1 1
MLKL KIAA1614 0 0 0 189 1 1
MLKL PDHX 0 0 47 290 1 1
MLKL STAT5A 0 0 66 189 1 1
MLKL BIRC7 0 0 132 199 1 1
MLKL XAF1 0 0 75 324 1 1
MLKL FAF1 0 0 74 157 1 1
MLKL TNIP1 0 0 120 164 1 1
MLKL FASLG 0 0 469 469 1 1
MLKL SOCS3 0 0 63 219 1 1
MLKL GSK3A 0 0 0 177 1 1
MLKL BIRC5 0 0 81 205 1 2
MLKL ARPIN 0 0 135 488 1 1
MLKL PIKFYVE 0 0 85 264 1 2
MLKL BIRC8 0 0 140 228 1 1
MLKL CXCL10 0 0 156 214 1 2
MLKL ITPK1 0 0 244 243 1 1
MLKL TLR9 0 0 234 272 1 2
MLKL PYCARD 0 0 321 354 1 2
MLKL NLRP7 0 0 148 184 1 1
MLKL GYS2 0 0 0 157 1 1
MLKL IRF3 0 0 317 327 1 2
MLKL AKT1 0 0 282 297 1 2
MLKL CD4 0 0 230 249 1 2
MLKL GNAL 0 0 0 158 1 1
MLKL UCKL1 0 0 0 171 1 1
MLKL CARD14 0 0 0 186 1 1
MLKL ATF6 0 0 164 184 1 2
MLKL IKBKB 0 0 325 168 1 2
MLKL PANX1 0 0 181 181 1 1
MLKL KLHL36 0 0 174 173 1 1
MLKL XIAP 0 0 503 554 1 2
MLKL PDK3 0 0 0 197 1 1
MLKL KDSR 0 0 0 173 1 1
MLKL PPBP 0 0 0 151 1 1
MLKL CHMP4A 0 600 215 689 1 1
MLKL LRRK1 0 0 92 167 1 1
MLKL RHOH 0 0 0 161 1 1
MLKL GLTP 0 0 141 159 1 1
MLKL HMOX1 0 0 160 173 1 2
MLKL PTPRQ 0 0 0 181 1 1
MLKL ERAL1 0 0 0 156 1 1
MLKL TOMM20 0 0 210 222 1 2
MLKL STX17 0 0 118 164 1 2
MLKL HACE1 0 0 82 223 1 1
MLKL PPM1D 0 0 52 278 1 1
MLKL SLC30A2 0 0 54 323 1 1
MLKL IFIT1 0 0 103 172 1 1
MLKL YWHAB 0 0 47 171 1 1
MLKL SPRED1 0 0 0 158 1 1
MLKL GPN2 0 0 0 158 1 1
MLKL GRAP 0 0 0 174 1 1
MLKL CHMP7 0 600 0 600 1 1
MLKL RNASEH1 0 0 0 179 1 1
MLKL RABGEF1 0 0 0 168 1 1
MLKL FRMPD2 0 0 0 193 1 1
MLKL STAT6 0 0 49 184 1 1
MLKL TNFSF12 0 0 181 181 1 1
MLKL EIF2AK3 0 0 208 236 1 2
MLKL ENAH 0 0 0 158 1 1
MLKL CDK1 111 0 81 198 1 2
MLKL TTBK1 0 0 0 164 1 1
MLKL RPS6KB1 0 0 104 177 1 2
MLKL DDX60 0 0 103 180 1 1
MLKL HSPA9 0 0 62 182 1 1
MLKL CBL 0 0 57 216 1 1
MLKL CLIC3 0 0 0 150 1 1
MLKL ALDH2 0 0 136 165 1 2
MLKL CD274 0 0 96 183 1 2
MLKL GRID1 0 0 0 150 1 2
MLKL BAK1 0 0 204 221 1 2
MLKL PITPNA 177 0 453 548 1 1
MLKL RNASEL 0 0 108 323 1 1
MLKL NUMBL 0 0 0 159 1 1
MLKL CHMP1A 0 600 0 612 1 1
MLKL PDPK1 0 0 0 192 1 2
MLKL CAT 0 0 124 164 1 2
MLKL C22orf29 0 0 219 219 1 1
MLKL TNF 0 0 611 654 1 2
MLKL NBR1 0 0 60 211 1 2
MLKL TRAP1 0 0 0 174 1 2
MLKL FIS1 0 0 135 228 1 2
MLKL NAIP 0 0 270 409 1 1
MLKL SLC7A11 0 0 183 229 1 2
MLKL RBFOX3 0 0 163 175 1 1
MLKL NFKB2 0 0 122 242 1 1
MLKL TNFAIP3 0 0 170 278 1 2
MLKL SDCBP 0 0 397 419 1 1
MLKL RPS6KA2 0 0 46 160 1 1
MLKL MAP3K14 0 0 90 151 1 1
MLKL FAM173B 0 0 180 193 1 1
MLKL IFI16 0 0 136 211 1 1
MLKL BMF 0 0 232 237 1 1
MLKL RAB7A 0 0 102 157 1 2
MLKL PARD6A 0 0 0 189 1 1
MLKL IFI35 0 0 45 236 1 1
MLKL IRF7 0 0 194 270 1 1
MLKL GLUD1 0 0 345 368 1 1
MLKL PRF1 0 0 150 169 1 1
MLKL GSDMB 0 0 166 165 1 1
MLKL SPRED3 0 0 0 158 1 1
MLKL IFIH1 0 0 183 258 1 1
MLKL BCKDK 0 0 0 197 1 1
MLKL GRAPL 0 0 0 170 1 1
MLKL SHANK2 0 0 0 161 1 1
MLKL CD59 0 0 117 173 1 1
MLKL ARL11 0 0 0 166 1 1
MLKL OIT3 0 0 108 160 1 1
MLKL CASP9 0 0 460 472 1 2
MLKL RPS6KA4 0 0 0 155 1 1
MLKL TLR7 0 0 160 227 1 2
MLKL MAPK9 0 0 142 238 1 2
MLKL ZNF7 0 0 195 228 1 1
MLKL PSKH2 0 0 150 188 1 1
MLKL RPS6KA3 0 0 45 159 1 1
MLKL AAR2 257 0 0 273 1 1
MLKL BPTF 0 0 0 285 1 1
MLKL DLG5 0 0 0 159 1 1
MLKL TRIB1 0 0 81 197 1 1
MLKL GNAS 0 0 0 158 1 1
MLKL GSKIP 0 0 0 196 1 1
MLKL PPIB 0 0 0 152 1 1
MLKL HSPG2 0 0 0 193 1 1
MLKL PHF11 0 0 66 166 1 1
MLKL ALG1L2 0 0 0 157 1 1
MLKL LRRFIP1 0 0 96 519 1 1
MLKL PPM1G 0 0 49 205 1 1
MLKL CASP8 246 0 845 927 1 2
MLKL XPO7 0 0 0 181 1 1
MLKL TNFRSF10A 0 0 342 374 1 1
MLKL IFI44L 0 0 90 170 1 1
MLKL PLCL2 0 0 0 160 1 1
MLKL FOLR3 0 0 0 162 1 1
MLKL TRIM21 0 0 102 212 1 1
MLKL SNX15 0 0 0 204 1 1
MLKL YWHAG 0 0 0 165 1 1
MLKL MAPKAPK2 0 0 123 174 1 1
MLKL AIM2 0 0 369 386 1 2
MLKL DDX58 0 0 285 346 1 1
MLKL IL1A 0 0 325 325 1 1
MLKL MAVS 0 0 321 346 1 2
MLKL CHMP3 0 600 0 644 1 1
MLKL PIK3R5 0 0 46 178 1 1
MLKL LLGL1 0 0 0 158 1 1
MLKL RNF31 0 0 469 481 1 1
MLKL GABARAPL1 0 0 120 176 1 2
MLKL PDK2 0 0 0 197 1 1
MLKL ADAD1 0 0 66 200 1 1
MLKL NIM1K 0 0 0 158 1 1
MLKL CBLC 0 0 0 203 1 1
MLKL TLR5 0 0 123 166 1 1
MLKL HSPA8 0 0 53 181 1 2
MLKL GDF10 0 0 43 151 1 1
MLKL PARP1 0 0 392 408 1 2
MLKL RHOA 0 0 82 176 1 2
MLKL LLGL2 0 0 0 158 1 1
MLKL JUP 0 0 0 171 1 1
MLKL KEAP1 0 0 193 196 1 2
MLKL ROS1 0 0 0 177 1 1
MLKL CSNK1E 0 0 0 164 1 1
MLKL INHBE 0 0 56 163 1 1
MLKL FPR2 0 0 61 162 1 1
MLKL SPG7 0 0 52 186 1 1
MLKL CD40 0 0 113 252 1 2
MLKL STUB1 0 0 206 302 1 2
MLKL RPS6KA6 0 0 0 155 1 1
MLKL ACTB 0 0 459 498 1 2
MLKL COX4I1 0 0 170 182 1 1
MLKL DYRK2 0 0 67 150 1 1
MLKL HTRA2 0 0 240 254 1 1
MLKL TFEB 0 0 125 158 1 2
MLKL RHOT1 0 0 63 178 1 1
MLKL TNIP3 0 0 49 273 1 1
MLKL TMEM173 0 0 103 187 1 1
MLKL BCL2L11 0 0 259 287 1 2
MLKL MAPK12 0 0 0 184 1 1
MLKL HSPA1A 0 0 113 248 1 1
MLKL TNFSF10 0 0 459 487 1 2
MLKL MAP2K3 0 0 75 158 1 1
MLKL VRK2 0 0 0 164 1 1
MLKL CASP1 0 0 609 684 1 2
MLKL TFAM 0 0 95 161 1 2
MLKL RIPK2 0 0 443 266 1 2
MLKL PSMB8 0 0 60 160 1 1
MLKL ARHGEF2 0 0 0 175 1 1
MLKL CALR 0 0 156 175 1 1
MLKL FUNDC1 0 0 171 181 1 2
MLKL CD8A 0 0 261 272 1 1
MLKL MIB2 0 0 61 234 1 1
MLKL CSNK1A1 0 0 73 153 1 1
MLKL TICAM1 0 0 456 476 1 2
MLKL LAMP2 0 0 118 183 1 2
MLKL YWHAE 0 0 0 165 1 1
MLKL BIRC2 0 0 652 681 1 1
MLKL IFNG 0 0 109 220 1 2
MLKL CCL5 0 0 144 203 1 2
MLKL MAPK4 0 0 0 184 1 1
MLKL PRKACA 0 0 60 155 1 1
MLKL HAVCR1 0 0 123 155 1 1
MLKL HSPA1L 0 0 0 166 1 1
MLKL GSDMA 0 0 505 505 1 1
MLKL MAPKBP1 0 0 0 185 1 1
MLKL PDP2 0 0 0 201 1 1
MLKL PLEC 0 0 0 159 1 1
MLKL ANXA5 0 0 464 495 1 2
MLKL BCL2L1 0 0 358 358 1 2
MLKL PIK3R4 0 0 81 152 1 2
MLKL LONRF2 0 0 0 200 1 1
MLKL CLEC7A 0 0 134 186 1 1
MLKL TAB3 0 0 294 400 1 1
MLKL RPS6KA5 0 0 0 155 1 1
MLKL BRD1 154 0 0 172 1 1
MLKL NMI 0 0 0 214 1 1
MLKL GABARAPL2 0 0 123 179 1 2
MLKL CHMP1B 0 600 0 612 1 1
MLKL NF1 0 0 0 155 1 1
MLKL CLIC6 0 0 0 167 1 1
MLKL KSR2 0 0 89 151 1 1
MLKL TLR4 0 0 463 519 1 2
MLKL ATG14 0 0 181 239 1 2
MLKL TNFRSF25 0 0 195 213 1 1
MLKL RNF11 0 0 74 188 1 1
MLKL DOK7 0 0 0 175 1 1
MLKL MAPK13 0 0 0 184 1 1
MLKL GRIK3 0 0 0 150 1 1
MLKL TRPM7 0 800 552 906 1 1
MLKL HIF1A 0 0 170 195 1 2
MLKL OAS1 0 0 54 177 1 1
MLKL TRAF5 0 0 368 523 1 1
MLKL PYGL 0 0 326 356 1 1
MLKL IL1B 0 0 519 576 1 2
MLKL CSNK1G1 0 0 74 154 1 1
MLKL TNFRSF1B 0 0 82 165 1 1
MLKL HERC5 0 0 0 166 1 1
MLKL MAP1LC3A 0 0 122 262 1 2
MLKL ZNF134 0 0 122 158 1 1
MLKL NLRP1 0 0 282 297 1 1
MLKL DDX21 0 0 0 220 1 1
MLKL PIDD1 0 0 114 260 1 1
MLKL BRD2 154 0 0 243 1 1
MLKL TNFRSF1A 0 0 681 695 1 1
MLKL VPS4A 0 600 90 626 1 1
MLKL RAB12 0 0 0 182 1 2
MLKL MPO 0 0 260 289 1 2
MLKL CHMP2B 0 600 46 614 1 2
MLKL FRAT2 0 0 57 179 1 1
MLKL IL6 0 0 372 387 1 2
MLKL FADD 0 0 802 841 1 2
MLKL MYD88 0 0 334 448 1 2
MLKL TRIM24 154 0 0 168 1 1
MLKL TTBK2 0 0 0 164 1 1
MLKL SLMAP 0 0 0 239 1 1
MLKL TXK 0 0 156 212 1 1
MLKL CSF3 0 0 106 267 1 1
MLKL KIF15 0 0 45 154 1 1
MLKL PPP1R27 0 0 66 164 1 1
MLKL TRAF1 0 0 145 253 1 1
MLKL PCP4L1 0 0 108 170 1 1
MLKL TGM1 0 0 0 189 1 1
MLKL RPGR 0 0 0 159 1 1
MLKL SH3BP5 0 0 234 289 1 1
MLKL KDM7A 0 0 0 182 1 1
MLKL STAT3 0 0 167 258 1 2
MLKL TRIM23 0 0 0 169 1 1
MLKL ERN1 0 0 193 219 1 2
MLKL TAB2 0 0 391 440 1 2
MLKL CORO6 0 0 0 162 1 1
MLKL IL1R1 0 0 193 205 1 1
MLKL ARL8B 0 0 0 151 1 1
MLKL PDK1 0 0 0 197 1 2
MLKL MYC 0 0 141 163 1 2
MLKL CHMP4C 0 600 0 614 1 1
MLKL IL18 0 0 458 473 1 2
MLKL PLAC8L1 0 0 181 181 1 1
MLKL GNAT2 0 0 0 177 1 1
MLKL EFNA4 0 0 0 168 1 1
MLKL TRAF2 270 0 459 668 1 2
MLKL GNAT3 0 0 0 177 1 1
MLKL TAB1 0 0 194 326 1 1
MLKL DHX33 0 0 180 271 1 1
MLKL TAX1BP1 0 0 96 165 1 2
MLKL SHANK1 0 0 0 161 1 1
MLKL STXBP6 0 0 0 158 1 1
MLKL EFNA5 0 0 0 168 1 1
MLKL NCKAP1L 0 0 0 152 1 1
MLKL DSP 0 0 0 163 1 1
MLKL RBCK1 0 0 457 477 1 1
MLKL DHX58 0 0 107 180 1 1
MLKL MFF 0 0 401 400 1 1
MLKL VASP 0 0 0 179 1 1
MLKL MAP2K1 0 0 53 190 1 1
MLKL PPIF 0 0 503 511 1 1
MLKL SLC30A3 0 0 0 176 1 1
MLKL TLR1 0 0 135 240 1 1
MLKL PGAM5 0 800 906 985 1 1
MLKL WDR62 0 0 0 185 1 1
MLKL MAP2K5 0 0 54 190 1 1
MLKL UCK1 0 0 0 171 1 1
MLKL ENSG00000272772 0 0 0 196 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005524 Molecular Function ATP binding enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0004672 Molecular Function protein kinase activity NOT enables ISS
GO:0019901 Molecular Function protein kinase binding enables IEA
GO:0004674 Molecular Function protein serine/threonine kinase activity NOT enables IBA
GO:0044877 Molecular Function protein-containing complex binding enables IDA
GO:0007166 Biological Process cell surface receptor signaling pathway involved_in IEA
GO:0051607 Biological Process defense response to virus involved_in ISS
GO:0097528 Biological Process execution phase of necroptosis involved_in IDA
GO:0097528 Biological Process execution phase of necroptosis involved_in ISS
GO:0070266 Biological Process necroptotic process involved_in IMP
GO:0097527 Biological Process necroptotic signaling pathway involved_in IMP
GO:0070207 Biological Process protein homotrimerization involved_in IDA
GO:0030054 Cellular Component cell junction located_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005634 Cellular Component nucleus located_in ISS
GO:0005886 Cellular Component plasma membrane located_in IDA
Pathways
Name DB ID
Disease Reactome R-HSA-1643685
Stimuli-sensing channels Reactome R-HSA-2672351
TRP channels Reactome R-HSA-3295583
Transport of small molecules Reactome R-HSA-382551
RIPK1-mediated regulated necrosis Reactome R-HSA-5213460
Regulated Necrosis Reactome R-HSA-5218859
Programmed Cell Death Reactome R-HSA-5357801
Regulation of necroptotic cell death Reactome R-HSA-5675482
Diseases of programmed cell death Reactome R-HSA-9645723
Microbial modulation of RIPK1-mediated regulated necrosis Reactome R-HSA-9686347
Defective RIPK1-mediated regulated necrosis Reactome R-HSA-9693928
Ion channel transport Reactome R-HSA-983712
DNA damage response (only ATM dependent) (WP710) WikiPathways WP710_r116542
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_005255834 5 mRNA transcript variant X1 NC_000016 Reference
NM_001142497 3 mRNA transcript variant 2 NC_000016 Reference
NM_152649 4 mRNA transcript variant 1 NC_000016 Reference
XM_047433704 1 mRNA transcript variant X2 NC_000016 Reference
XM_047433710 1 mRNA transcript variant X9 NC_000016 Reference
XM_047433707 1 mRNA transcript variant X5 NC_000016 Reference
XM_047433705 1 mRNA transcript variant X3 NC_000016 Reference
XM_047433708 1 mRNA transcript variant X6 NC_000016 Reference
XM_047433709 1 mRNA transcript variant X7 NC_000016 Reference
XM_047433706 1 mRNA transcript variant X4 NC_000016 Reference
XM_011522936 3 mRNA transcript variant X8 NC_000016 Reference