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SPRED2

sprouty related EVH1 domain containing 2
General Information
Name sprouty related EVH1 domain containing 2
Alias
  • sprouty-related, EVH1 domain-containing protein 2
  • sprouty protein with EVH-1 domain 2, related sequence
Gene_family
organism Homo sapiens
entrez_id 200734
location 2p14
transcript_count 9
exon_count 11
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
    Stringdb Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases
    nextProt Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
SPRED2 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA; Two-hybrid
SPRED2 BioGRID ORF1ab GeneID BioGRID Two-hybrid
SPRED2 BioGRID SMCHD1 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID AP4M1 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID CLPP GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID GNG5 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID CPT2 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID DPP9 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID PPCS GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID FTO GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID ARFGAP1 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID PDP1 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID ZDHHC13 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID ACTL6B GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID FAM162A GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID ZDHHC17 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
SPRED2 BioGRID ATG7 GeneID BioGRID Phenotypic Suppression
SPRED2 BioGRID RHOB GeneID BioGRID Proximity Label-MS
SPRED2 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
SPRED2 BioGRID KRAS GeneID BioGRID Proximity Label-MS
SPRED2 BioGRID EGFR GeneID BioGRID Positive Genetic
SPRED2 BioGRID FBXW8 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID VSNL1 GeneID BioGRID Two-hybrid
SPRED2 BioGRID TSNAX GeneID BioGRID Two-hybrid
SPRED2 BioGRID QARS1 GeneID BioGRID Two-hybrid
SPRED2 BioGRID NDUFB7 GeneID BioGRID Two-hybrid
SPRED2 BioGRID MDFI GeneID BioGRID Two-hybrid
SPRED2 BioGRID AQP1 GeneID BioGRID Two-hybrid
SPRED2 BioGRID KRTAP2-3 GeneID BioGRID Two-hybrid
SPRED2 BioGRID KPRP GeneID BioGRID Two-hybrid
SPRED2 BioGRID KRTAP12-2 GeneID BioGRID Two-hybrid
SPRED2 BioGRID LCE1C GeneID BioGRID Two-hybrid
SPRED2 BioGRID ZNF575 GeneID BioGRID Two-hybrid
SPRED2 BioGRID LCE5A GeneID BioGRID Two-hybrid
SPRED2 BioGRID ZNF417 GeneID BioGRID Two-hybrid
SPRED2 BioGRID ZNF837 GeneID BioGRID Two-hybrid
SPRED2 BioGRID KRTAP2-4 GeneID BioGRID Two-hybrid
SPRED2 BioGRID ZNF414 GeneID BioGRID Two-hybrid
SPRED2 BioGRID RBM48 GeneID BioGRID Two-hybrid
SPRED2 BioGRID MYO15B GeneID BioGRID Two-hybrid
SPRED2 BioGRID ZNF250 GeneID BioGRID Two-hybrid
SPRED2 BioGRID SPG21 GeneID BioGRID Two-hybrid
SPRED2 BioGRID KCNIP1 GeneID BioGRID Two-hybrid
SPRED2 BioGRID RPS6KA6 GeneID BioGRID Two-hybrid
SPRED2 BioGRID LCE2B GeneID BioGRID Two-hybrid
SPRED2 BioGRID NCS1 GeneID BioGRID Two-hybrid
SPRED2 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
SPRED2 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
SPRED2 BioGRID NBR1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
SPRED2 BioGRID CTSD GeneID BioGRID Reconstituted Complex
SPRED2 BioGRID MTDH GeneID BioGRID Protein-RNA
SPRED2 BioGRID PRTFDC1 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID RPS6KA3 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID RPS6KA2 GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID GNAQ GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID STOM GeneID BioGRID Affinity Capture-MS
SPRED2 BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
SPRED2 Protein RHOA GeneID HPRD
SPRED2 Protein KIT GeneID HPRD
SPRED2 BioGRID TESK1 GeneID BioGRID Affinity Capture-Western
StringDB
A B experiments database textmining combined score hadb nhadb
SPRED2 CTNNB1 0 0 83 168 1 2
SPRED2 CDCP1 0 0 103 165 1 1
SPRED2 CLSTN3 0 0 123 195 1 1
SPRED2 MAP1LC3A 270 0 43 271 1 2
SPRED2 HRAS 0 900 151 943 1 2
SPRED2 DMTN 0 0 0 183 1 1
SPRED2 ARL8A 0 0 0 158 1 1
SPRED2 EGR1 0 0 134 154 1 2
SPRED2 EPHA2 0 0 0 211 1 1
SPRED2 PASK 0 0 0 151 1 1
SPRED2 WIPF3 0 0 57 237 1 1
SPRED2 ERBB2IP 0 0 113 185 1 1
SPRED2 ARL1 0 0 0 158 1 1
SPRED2 RHOBTB1 0 0 0 171 1 1
SPRED2 NEO1 0 0 0 160 1 1
SPRED2 IGSF9B 0 0 0 173 1 1
SPRED2 EDEM3 0 0 97 192 1 1
SPRED2 PSMC2 0 900 0 900 1 1
SPRED2 PLD4 0 0 161 350 1 1
SPRED2 GBX2 0 0 125 162 1 1
SPRED2 ARF3 0 0 0 179 1 1
SPRED2 SERTAD1 0 0 211 265 1 1
SPRED2 MPO 0 0 0 173 1 2
SPRED2 RAB12 0 0 0 182 1 2
SPRED2 ZNF575 171 0 0 171 1 1
SPRED2 CCDC85B 0 0 178 177 1 1
SPRED2 PPP1R26 0 0 233 265 1 1
SPRED2 EGFL8 0 0 0 229 1 1
SPRED2 ACTR2 0 0 142 294 1 1
SPRED2 DNAJB4 0 0 0 329 1 1
SPRED2 DACT2 0 0 107 350 1 1
SPRED2 FGF13 0 0 74 206 1 1
SPRED2 RRAS 0 0 114 244 1 1
SPRED2 PRICKLE1 0 0 0 186 1 1
SPRED2 ARAF 0 0 74 214 1 1
SPRED2 FLRT2 0 0 149 205 1 1
SPRED2 PTGS1 0 0 0 173 1 1
SPRED2 NOTCH1 0 0 115 174 1 2
SPRED2 PSMB4 0 900 0 900 1 1
SPRED2 RHOU 0 0 0 205 1 1
SPRED2 PSMC6 0 900 46 900 1 1
SPRED2 PTPRU 0 0 0 220 1 1
SPRED2 RAB40B 0 0 142 157 1 1
SPRED2 WASL 0 0 0 161 1 1
SPRED2 WNT8A 0 0 60 170 1 1
SPRED2 ZDHHC17 270 0 108 506 1 1
SPRED2 FAM126B 0 0 0 261 1 1
SPRED2 RHOJ 0 0 0 171 1 1
SPRED2 CTNND1 0 0 0 196 1 1
SPRED2 GRID2IP 0 0 0 231 1 1
SPRED2 RGS4 0 0 124 211 1 1
SPRED2 DIAPH1 0 0 0 198 1 1
SPRED2 GRB10 0 0 0 294 1 1
SPRED2 ARL3 0 0 0 158 1 1
SPRED2 NTN3 0 0 0 160 1 1
SPRED2 PSMB1 0 900 0 901 1 1
SPRED2 TRIM9 0 0 0 213 1 1
SPRED2 PSMA1 0 900 0 900 1 1
SPRED2 ARF1 0 0 0 158 1 1
SPRED2 RHOBTB2 0 0 0 190 1 1
SPRED2 TOP3B 428 0 0 453 1 1
SPRED2 BAP1 0 0 66 209 1 1
SPRED2 IL2RB 0 0 108 245 1 1
SPRED2 ELOVL2 0 0 0 162 1 1
SPRED2 C20orf196 0 0 231 230 1 1
SPRED2 ARL14 0 0 0 158 1 1
SPRED2 PLCG2 0 0 0 219 1 1
SPRED2 SH2B3 0 0 181 181 1 1
SPRED2 KSR2 0 0 0 186 1 1
SPRED2 DUSP5 0 0 283 293 1 1
SPRED2 TRIM43 0 0 150 172 1 1
SPRED2 BCL9L 0 0 89 254 1 1
SPRED2 RIT2 0 0 81 265 1 1
SPRED2 ZMAT4 0 0 180 186 1 1
SPRED2 PTPN9 0 0 96 194 1 1
SPRED2 ARL5B 0 0 0 158 1 1
SPRED2 RAP1A 0 0 0 195 1 1
SPRED2 ENSG00000273748 0 0 150 160 1 1
SPRED2 MAP2K7 0 0 194 270 1 1
SPRED2 CRIM1 0 0 120 212 1 1
SPRED2 MAP6 0 0 73 155 1 1
SPRED2 ABL1 0 0 82 461 1 1
SPRED2 NF1 0 500 665 908 1 1
SPRED2 ETAA1 0 0 135 515 1 1
SPRED2 KITLG 0 0 358 376 1 1
SPRED2 FHL5 0 0 0 186 1 1
SPRED2 CLDN15 0 0 0 245 1 1
SPRED2 STAT4 0 0 287 286 1 1
SPRED2 EPHA8 0 0 0 188 1 1
SPRED2 FBXO42 0 0 171 298 1 1
SPRED2 ZAP70 0 0 0 184 1 1
SPRED2 TPO 0 0 0 173 1 1
SPRED2 AFF3 0 0 392 405 1 1
SPRED2 ABLIM2 0 0 53 193 1 1
SPRED2 NTNG2 0 0 0 160 1 1
SPRED2 DUPD1 0 0 103 153 1 1
SPRED2 PIM1 0 0 150 203 1 1
SPRED2 GNAQ 184 0 0 201 1 1
SPRED2 CBX4 0 0 66 159 1 1
SPRED2 PLAC8L1 0 0 113 176 1 1
SPRED2 IL2RA 0 0 260 260 1 1
SPRED2 ARL8B 0 0 0 158 1 1
SPRED2 MYC 0 0 113 152 1 2
SPRED2 PTPRN2 0 0 0 164 1 1
SPRED2 PFN4 0 0 0 310 1 1
SPRED2 WFS1 0 0 60 158 1 1
SPRED2 DSN1 0 0 108 169 1 1
SPRED2 WNT5A 0 0 74 211 1 2
SPRED2 C5orf30 0 0 377 377 1 1
SPRED2 RALGDS 0 0 90 171 1 1
SPRED2 CKS2 0 0 72 234 1 1
SPRED2 IGF1R 0 0 71 159 1 2
SPRED2 ABI3 0 0 0 188 1 1
SPRED2 TCERG1 0 0 0 161 1 1
SPRED2 GRB14 0 0 0 294 1 1
SPRED2 ROBO4 0 0 0 308 1 1
SPRED2 RASAL1 0 500 54 528 1 1
SPRED2 TAGAP 0 0 261 261 1 1
SPRED2 RIT1 0 0 56 237 1 1
SPRED2 FBXW8 270 0 0 270 1 1
SPRED2 BCL7A 0 0 134 283 1 1
SPRED2 PSMB3 0 900 0 900 1 1
SPRED2 DAB2IP 0 500 45 540 1 2
SPRED2 SPRY3 0 0 379 261 1 1
SPRED2 PPP1R1B 0 0 48 308 1 1
SPRED2 FRS2 0 0 160 206 1 1
SPRED2 RSG1 0 0 0 182 1 1
SPRED2 KIAA1024L 0 0 181 181 1 1
SPRED2 CCL21 0 0 243 242 1 1
SPRED2 PSMA6 0 900 0 900 1 1
SPRED2 MAP2K1 0 0 202 302 1 1
SPRED2 MAP3K8 0 0 95 151 1 1
SPRED2 FZD2 0 0 48 152 1 1
SPRED2 VASP 0 0 540 251 1 1
SPRED2 AMMECR1 0 0 0 177 1 1
SPRED2 JPH3 0 0 108 204 1 1
SPRED2 MEF2D 0 0 0 183 1 2
SPRED2 LRIG3 0 0 138 217 1 1
SPRED2 PBK 0 0 0 158 1 1
SPRED2 FHL2 0 0 0 186 1 1
SPRED2 CYFIP1 0 0 0 229 1 1
SPRED2 AMMECR1L 0 0 0 177 1 1
SPRED2 DUSP4 0 0 241 337 1 1
SPRED2 FHDC1 0 0 0 231 1 1
SPRED2 PKIA 0 0 108 201 1 1
SPRED2 OEBT 0 0 234 350 1 1
SPRED2 RAF1 0 0 435 498 1 2
SPRED2 PTPRD 0 0 0 196 1 1
SPRED2 CMTM6 0 0 134 274 1 1
SPRED2 TRAF1 0 0 260 273 1 1
SPRED2 MLIP 0 0 156 155 1 1
SPRED2 FHOD1 0 0 0 166 1 1
SPRED2 GOLIM4 0 0 108 163 1 1
SPRED2 ENSG00000124593 0 0 234 350 1 1
SPRED2 CT83 0 0 162 161 1 1
SPRED2 APBB1IP 0 0 0 294 1 1
SPRED2 MAP3K7 0 0 0 158 1 2
SPRED2 LPP 0 0 0 202 1 1
SPRED2 PSMA8 0 900 0 900 1 1
SPRED2 RASGRP2 0 0 90 182 1 1
SPRED2 ARF5 0 0 0 158 1 1
SPRED2 KIF5C 0 0 0 169 1 1
SPRED2 PRKCI 0 0 0 174 1 1
SPRED2 HOXA13 0 0 74 185 1 1
SPRED2 RAB2A 0 0 0 158 1 1
SPRED2 NCKAP1 0 0 0 153 1 1
SPRED2 STAU1 0 0 0 165 1 1
SPRED2 CCDC67 0 0 155 217 1 1
SPRED2 RAB4A 0 0 0 158 1 1
SPRED2 FGFR3 0 0 95 181 1 1
SPRED2 PPP1CC 0 0 0 152 1 1
SPRED2 SLAIN1 0 0 158 232 1 1
SPRED2 EGFR 0 0 454 482 1 2
SPRED2 KANK1 0 0 90 152 1 1
SPRED2 PSMD13 0 900 0 900 1 1
SPRED2 PTPRT 0 0 81 265 1 1
SPRED2 TRIM23 0 0 0 158 1 1
SPRED2 FHOD3 0 0 0 166 1 1
SPRED2 FMN2 0 0 0 231 1 1
SPRED2 PYCR1 0 0 0 188 1 1
SPRED2 PTPN22 0 0 321 394 1 1
SPRED2 RFC3 0 0 81 196 1 1
SPRED2 TGFA 0 0 75 449 1 1
SPRED2 TRIM8 0 0 0 303 1 1
SPRED2 CD300C 0 0 123 258 1 1
SPRED2 RASGRP3 0 0 81 332 1 1
SPRED2 JAK2 0 0 94 179 1 2
SPRED2 DIRAS1 0 0 0 182 1 1
SPRED2 WASF3 0 0 0 238 1 1
SPRED2 WNT5B 0 0 52 192 1 1
SPRED2 KIAA1217 0 0 134 152 1 1
SPRED2 PSME3 0 900 0 902 1 1
SPRED2 G3BP2 0 0 0 178 1 1
SPRED2 FLRT1 0 0 134 213 1 1
SPRED2 SHFM1 0 900 0 900 1 1
SPRED2 PSMD10 0 900 0 900 1 1
SPRED2 LIMD1 0 0 0 174 1 1
SPRED2 KLF10 0 0 0 210 1 1
SPRED2 PRTG 0 0 0 160 1 1
SPRED2 ENSG00000272822 0 0 0 158 1 1
SPRED2 ADD3 0 0 0 224 1 1
SPRED2 ANKRD55 0 0 450 450 1 1
SPRED2 RAP1B 0 0 0 195 1 1
SPRED2 A2ML1 0 0 113 168 1 1
SPRED2 ROBO3 0 0 0 308 1 1
SPRED2 UBE2QL1 0 0 166 184 1 1
SPRED2 RAPH1 0 0 0 314 1 1
SPRED2 MLLT4 0 0 0 163 1 1
SPRED2 ARL17A 0 0 0 158 1 1
SPRED2 SNAI2 0 0 48 206 1 1
SPRED2 RNF207 0 0 0 213 1 1
SPRED2 BCL9 0 0 81 212 1 1
SPRED2 ENSG00000255863 0 0 0 158 1 1
SPRED2 RAP2A 0 0 0 186 1 1
SPRED2 COMMD1 0 0 0 189 1 1
SPRED2 RAP1GAP2 0 0 170 323 1 1
SPRED2 RESP18 0 0 0 164 1 1
SPRED2 PSMA4 0 900 0 900 1 1
SPRED2 DAAM1 0 0 0 231 1 1
SPRED2 PIK3R5 0 0 122 191 1 1
SPRED2 MAP3K11 0 0 0 158 1 1
SPRED2 ZYX 0 0 0 174 1 1
SPRED2 PSMB2 0 900 0 900 1 1
SPRED2 FNDC1 0 0 0 160 1 1
SPRED2 RHOB 0 0 0 171 1 1
SPRED2 PPP1CB 0 0 44 153 1 1
SPRED2 GPR20 0 0 165 165 1 1
SPRED2 EPHA4 0 0 94 233 1 1
SPRED2 MAP3K9 0 0 0 158 1 1
SPRED2 LAX1 0 0 95 257 1 1
SPRED2 FKBP4 0 0 0 183 1 1
SPRED2 DUSP8 0 0 170 182 1 1
SPRED2 RERG 0 0 0 182 1 1
SPRED2 PTPRJ 0 0 0 218 1 1
SPRED2 PRKCZ 0 0 0 174 1 1
SPRED2 RAP2B 0 0 0 182 1 1
SPRED2 SCG2 0 0 74 233 1 1
SPRED2 ABLIM3 0 0 0 183 1 1
SPRED2 NAA25 0 0 183 203 1 1
SPRED2 GRB7 0 0 0 294 1 1
SPRED2 FZD7 0 0 0 167 1 1
SPRED2 ARL9 0 0 0 158 1 1
SPRED2 BTG3 0 0 158 157 1 1
SPRED2 CBFA2T3 0 0 74 213 1 1
SPRED2 BRAF 0 0 0 163 1 2
SPRED2 ARL4D 0 0 0 158 1 1
SPRED2 FBLIM1 0 0 0 174 1 1
SPRED2 FGF18 0 0 128 411 1 1
SPRED2 NTNG1 0 0 0 197 1 1
SPRED2 GAB4 0 0 0 309 1 1
SPRED2 TBXA2R 0 0 74 167 1 1
SPRED2 LPO 0 0 0 173 1 1
SPRED2 SPRED3 0 500 764 544 1 1
SPRED2 PSMD11 0 900 0 900 1 1
SPRED2 RASA4 0 500 95 538 1 1
SPRED2 PAQR9 0 0 166 188 1 1
SPRED2 CISH 0 0 155 247 1 1
SPRED2 ABL2 0 0 0 416 1 1
SPRED2 GSKIP 0 0 103 176 1 1
SPRED2 ETV5 0 0 321 353 1 1
SPRED2 ZDHHC13 0 0 161 496 1 1
SPRED2 DIAPH2 0 0 0 198 1 1
SPRED2 MAMDC2 0 0 137 280 1 1
SPRED2 PTPRK 0 0 0 196 1 1
SPRED2 PIK3R1 0 0 82 179 1 1
SPRED2 RDX 0 0 0 265 1 1
SPRED2 PDE2A 0 0 112 269 1 1
SPRED2 PSMD4 0 900 0 900 1 1
SPRED2 DAB2 0 0 123 196 1 1
SPRED2 TRIB1 0 0 134 157 1 1
SPRED2 RBM47 0 0 113 211 1 1
SPRED2 ARL5C 0 0 0 158 1 1
SPRED2 CASP9 0 0 57 200 1 2
SPRED2 ELOVL1 0 0 0 426 1 1
SPRED2 RPS6KA3 179 0 52 188 1 1
SPRED2 RAC3 0 0 0 171 1 2
SPRED2 SHOC2 0 0 134 178 1 1
SPRED2 PTPN3 0 0 0 159 1 1
SPRED2 PTPRS 0 0 61 213 1 1
SPRED2 GNAZ 0 0 112 192 1 1
SPRED2 EGF 0 0 204 253 1 2
SPRED2 RASAL3 0 500 60 518 1 1
SPRED2 PELI1 0 0 166 165 1 1
SPRED2 ADD2 0 0 93 660 1 1
SPRED2 TIAM2 0 0 95 208 1 1
SPRED2 ARL11 0 0 0 158 1 1
SPRED2 ARID5B 0 0 103 290 1 1
SPRED2 HLA-DRB1 0 0 174 173 1 1
SPRED2 CAV1 0 0 388 402 1 2
SPRED2 GIN1 0 0 181 199 1 1
SPRED2 PTPN21 0 0 0 203 1 1
SPRED2 SH2D3C 0 0 0 187 1 1
SPRED2 ARL17B 0 0 0 158 1 1
SPRED2 PADI4 0 0 244 243 1 1
SPRED2 NEK8 0 0 84 291 1 1
SPRED2 ACTR3 0 0 0 175 1 1
SPRED2 TJP3 0 0 0 170 1 1
SPRED2 TRIO 0 0 48 162 1 1
SPRED2 TMEM130 0 0 157 221 1 1
SPRED2 PXDN 0 0 0 173 1 1
SPRED2 RHOT1 0 0 0 158 1 1
SPRED2 PLCG1 0 0 0 239 1 1
SPRED2 FZD1 0 0 0 170 1 1
SPRED2 ARL4A 0 0 0 158 1 1
SPRED2 MKX 0 0 172 677 1 1
SPRED2 GRB2 0 0 203 377 1 1
SPRED2 ARL10 0 0 0 158 1 1
SPRED2 NFKBIE 0 0 66 159 1 1
SPRED2 PSMD1 0 900 0 902 1 1
SPRED2 ABI1 0 0 0 188 1 1
SPRED2 RTN1 0 0 141 192 1 1
SPRED2 HIVEP3 0 0 96 215 1 1
SPRED2 CREB3L2 0 0 74 170 1 1
SPRED2 CCRL2 0 0 218 218 1 1
SPRED2 ZAK 0 0 0 158 1 1
SPRED2 DNAJC3 0 0 0 205 1 1
SPRED2 ELOVL6 0 0 0 189 1 1
SPRED2 FZD6 0 0 0 183 1 1
SPRED2 ACTR3C 0 0 0 175 1 1
SPRED2 RABL2A 0 0 57 172 1 1
SPRED2 PSMB8 0 900 0 900 1 1
SPRED2 RAP2C 0 0 0 186 1 1
SPRED2 RASD1 0 0 0 182 1 1
SPRED2 RIPK2 0 0 0 158 1 2
SPRED2 ETV1 0 0 205 341 1 1
SPRED2 CRK 0 0 54 159 1 1
SPRED2 NFATC3 0 0 0 232 1 1
SPRED2 SERTAD2 0 0 244 243 1 1
SPRED2 PLCH2 0 0 125 182 1 1
SPRED2 OLIG3 0 0 150 172 1 1
SPRED2 RHOA 213 0 57 331 1 2
SPRED2 ETV4 0 0 269 305 1 1
SPRED2 ATG9A 0 0 0 150 1 2
SPRED2 ERAS 0 0 0 182 1 1
SPRED2 RHOQ 0 0 0 171 1 1
SPRED2 LIMS2 0 0 0 174 1 1
SPRED2 GPR29 0 0 227 226 1 1
SPRED2 RASL12 0 0 0 182 1 1
SPRED2 PTPRC 0 0 113 256 1 1
SPRED2 MLKL 0 0 0 158 1 2
SPRED2 ENSG00000271810 0 0 0 171 1 1
SPRED2 COBLL1 0 0 113 347 1 1
SPRED2 RHOG 0 0 0 171 1 1
SPRED2 STK4 0 0 0 157 1 1
SPRED2 RAB1A 0 0 194 446 1 1
SPRED2 ROBO1 0 0 0 339 1 1
SPRED2 PTPRN 0 0 0 164 1 1
SPRED2 IGDCC3 0 0 0 463 1 1
SPRED2 RALB 0 0 90 254 1 2
SPRED2 MAP4K5 0 0 112 151 1 1
SPRED2 DUX4L8 0 0 157 156 1 1
SPRED2 IL3 0 0 294 294 1 1
SPRED2 NHS 0 0 0 188 1 1
SPRED2 KIF5A 0 0 234 336 1 1
SPRED2 VPS13C 0 0 0 224 1 1
SPRED2 RHOV 0 0 0 171 1 1
SPRED2 PRPF40B 0 0 0 161 1 1
SPRED2 PSMA2 0 900 0 900 1 1
SPRED2 EPHA7 0 0 0 188 1 1
SPRED2 ENSG00000255835 0 0 0 188 1 1
SPRED2 UHRF1BP1 0 0 193 193 1 1
SPRED2 FGF1 0 0 103 242 1 1
SPRED2 TES 0 0 0 186 1 1
SPRED2 CD40 0 0 156 155 1 2
SPRED2 RPS6KA6 237 0 0 237 1 1
SPRED2 ZNF185 0 0 0 186 1 1
SPRED2 EPHA10 0 0 0 188 1 1
SPRED2 MSN 0 0 44 571 1 1
SPRED2 CIT 0 0 0 154 1 1
SPRED2 DNAJB5 0 0 0 219 1 1
SPRED2 SQSTM1 675 0 248 745 1 2
SPRED2 MFNG 0 0 0 183 1 1
SPRED2 ARL6 0 0 0 158 1 1
SPRED2 MAPK3 0 0 194 244 1 2
SPRED2 RND1 0 0 0 171 1 1
SPRED2 PRKCD 0 0 92 292 1 2
SPRED2 STK3 0 0 0 157 1 1
SPRED2 LEUTX 0 0 181 181 1 1
SPRED2 DHCR24 0 0 0 404 1 1
SPRED2 RIPK3 0 0 0 158 1 2
SPRED2 PSMF1 0 900 0 900 1 1
SPRED2 RASSF5 0 0 137 178 1 1
SPRED2 RBX1 0 900 0 900 1 1
SPRED2 FRG1 0 0 144 154 1 1
SPRED2 STXBP2 0 0 0 190 1 1
SPRED2 MOS 0 0 0 158 1 1
SPRED2 TESK2 0 0 0 265 1 1
SPRED2 PTPRQ 0 0 0 274 1 1
SPRED2 NTN1 0 0 0 160 1 1
SPRED2 RAC2 0 0 0 171 1 1
SPRED2 RAB11A 0 0 75 188 1 2
SPRED2 WASF1 0 0 0 238 1 1
SPRED2 PTPN7 0 0 90 255 1 1
SPRED2 RHOH 0 0 0 171 1 1
SPRED2 NUDT6 0 0 124 483 1 1
SPRED2 CEP68 0 0 391 390 1 1
SPRED2 TICAM2 0 0 160 159 1 1
SPRED2 TBK1 0 0 73 167 1 2
SPRED2 TBX4 0 0 95 161 1 1
SPRED2 LRRK1 0 0 0 158 1 1
SPRED2 PTPN6 0 0 142 321 1 1
SPRED2 METTL14 0 0 141 163 1 1
SPRED2 PTPRM 0 0 86 244 1 1
SPRED2 TP53INP1 0 0 62 265 1 2
SPRED2 TUFT1 0 0 108 169 1 1
SPRED2 FAM126A 0 0 0 261 1 1
SPRED2 KBTBD7 0 900 0 900 1 1
SPRED2 RASA3 0 500 0 510 1 1
SPRED2 LANCL3 0 0 234 306 1 1
SPRED2 PSMD7 0 900 0 900 1 1
SPRED2 COASY 0 0 0 187 1 1
SPRED2 PSMB5 0 900 0 900 1 1
SPRED2 ABLIM1 0 0 0 183 1 1
SPRED2 CADM1 0 0 69 278 1 1
SPRED2 DNMBP 0 0 141 185 1 1
SPRED2 DNAJB1 0 0 0 219 1 2
SPRED2 PXK 0 0 501 521 1 1
SPRED2 ROBO2 0 0 82 337 1 1
SPRED2 EPHB3 0 0 0 188 1 1
SPRED2 CRTC1 0 0 414 414 1 2
SPRED2 CDC42 0 0 72 198 1 2
SPRED2 GPN2 0 0 0 158 1 1
SPRED2 DUX4L7 0 0 158 157 1 1
SPRED2 RAB25 0 0 0 158 1 2
SPRED2 SRC 0 0 74 190 1 2
SPRED2 METTL3 0 0 156 156 1 2
SPRED2 SPRED1 42 500 768 540 1 1
SPRED2 KIF5B 0 0 0 169 1 1
SPRED2 RAPGEF2 0 0 161 179 1 1
SPRED2 FMNL1 0 0 0 275 1 1
SPRED2 COMMD10 0 0 0 177 1 1
SPRED2 ACVR1B 0 0 72 177 1 1
SPRED2 C19orf10 0 0 0 183 1 1
SPRED2 FBXO2 0 0 101 201 1 1
SPRED2 PSMC1 0 900 0 900 1 1
SPRED2 NTN5 0 0 0 160 1 1
SPRED2 SYNGAP1 0 500 283 641 1 1
SPRED2 SPG21 470 0 0 470 1 1
SPRED2 IL6ST 0 0 323 323 1 1
SPRED2 ITM2B 0 0 112 173 1 1
SPRED2 NUTM2E 0 0 155 154 1 1
SPRED2 RHOC 0 0 0 171 1 1
SPRED2 PTPN23 0 0 0 165 1 1
SPRED2 GSK3A 0 0 0 158 1 1
SPRED2 TCERG1L 0 0 0 161 1 1
SPRED2 KIAA1804 0 0 0 158 1 1
SPRED2 PSMD5 0 900 60 901 1 1
SPRED2 EDF1 0 0 113 175 1 1
SPRED2 SPRY4 0 0 556 613 1 1
SPRED2 PSME4 0 900 0 900 1 1
SPRED2 ARF4 0 0 0 158 1 1
SPRED2 B3GNT2 0 0 134 400 1 1
SPRED2 PSMD8 0 900 0 900 1 1
SPRED2 FGFR1 0 0 113 197 1 1
SPRED2 SPATA5 0 0 115 482 1 1
SPRED2 VCAM1 0 0 0 185 1 1
SPRED2 ARL15 0 0 0 158 1 1
SPRED2 PRICKLE3 0 0 0 186 1 1
SPRED2 RASD2 0 0 0 182 1 1
SPRED2 AKT1 0 0 186 277 1 2
SPRED2 VPS13D 0 0 0 183 1 1
SPRED2 ARL5A 0 0 0 158 1 1
SPRED2 RABL2B 0 0 0 158 1 1
SPRED2 DIAPH3 0 0 0 198 1 1
SPRED2 PEBP1 0 0 260 260 1 1
SPRED2 ANKK1 0 0 0 158 1 1
SPRED2 TMSB4X 0 0 108 401 1 1
SPRED2 ABI2 0 0 0 188 1 1
SPRED2 RGS3 0 0 183 218 1 1
SPRED2 ADCY6 0 0 0 153 1 1
SPRED2 ELOVL7 0 0 0 303 1 1
SPRED2 LMCD1 0 0 0 186 1 1
SPRED2 PIK3R2 0 0 95 310 1 1
SPRED2 DAAM2 0 0 0 231 1 1
SPRED2 JPH2 0 0 0 183 1 1
SPRED2 TJP2 0 0 0 170 1 1
SPRED2 CDC42BPB 0 0 0 160 1 1
SPRED2 NBR1 486 0 451 785 1 2
SPRED2 EPHB6 0 0 0 188 1 1
SPRED2 PSMD6 0 900 0 900 1 1
SPRED2 SDK2 0 0 0 165 1 1
SPRED2 RAB39A 0 0 0 158 1 1
SPRED2 RHEBL1 0 0 46 186 1 1
SPRED2 MAPK1 0 0 329 370 1 2
SPRED2 G3BP1 0 0 0 178 1 1
SPRED2 RAB1B 0 0 57 268 1 2
SPRED2 EPHB4 0 0 0 188 1 1
SPRED2 FHL3 0 0 0 186 1 1
SPRED2 CTNNBL1 0 0 113 221 1 1
SPRED2 DUX4L1 0 0 155 154 1 1
SPRED2 C1QTNF6 0 0 141 227 1 1
SPRED2 BCAP31 0 0 0 197 1 1
SPRED2 TNFAIP3 0 0 264 264 1 2
SPRED2 EDEM1 0 0 61 153 1 2
SPRED2 SOS1 0 0 122 167 1 1
SPRED2 RND3 0 0 0 171 1 1
SPRED2 ENSG00000272980 0 0 226 225 1 1
SPRED2 PYCR2 0 0 0 188 1 1
SPRED2 RHOF 0 0 0 171 1 1
SPRED2 SPRY2 0 0 460 362 1 1
SPRED2 RPS6KA2 130 0 72 158 1 1
SPRED2 EPHA1 0 0 47 193 1 1
SPRED2 HOXD8 0 0 0 157 1 1
SPRED2 ARL16 0 0 0 158 1 1
SPRED2 KXD1 0 0 0 183 1 1
SPRED2 CCND1 0 0 106 157 1 2
SPRED2 PLEKHG2 0 0 181 187 1 1
SPRED2 ARAP1 0 0 112 365 1 1
SPRED2 PSME1 0 900 0 900 1 1
SPRED2 PTPRE 0 0 115 262 1 1
SPRED2 FIBCD1 0 0 62 202 1 1
SPRED2 RRAD 0 0 0 182 1 1
SPRED2 RERGL 0 0 0 182 1 1
SPRED2 EPHB1 0 0 72 214 1 1
SPRED2 CBL 270 0 96 368 1 1
SPRED2 IPO9 0 0 0 157 1 1
SPRED2 HGNC:9979 0 0 166 165 1 1
SPRED2 REM1 0 0 0 267 1 1
SPRED2 USHBP1 0 0 0 160 1 1
SPRED2 AFTPH 0 0 341 341 1 1
SPRED2 CRLF1 0 0 181 307 1 1
SPRED2 DUSP6 0 0 450 493 1 1
SPRED2 C18orf42 0 0 255 254 1 1
SPRED2 INF2 0 0 0 231 1 1
SPRED2 PSMA3 0 900 0 902 1 1
SPRED2 TESK1 270 0 0 452 1 1
SPRED2 DNAJC27 0 0 0 158 1 1
SPRED2 UBB 0 900 0 900 1 1
SPRED2 ENSG00000258973 0 0 0 158 1 1
SPRED2 EGFL7 0 0 0 229 1 1
SPRED2 STXBP3 0 0 0 171 1 1
SPRED2 MAP4K3 0 0 107 224 1 1
SPRED2 STAU2 0 0 0 165 1 1
SPRED2 RASA1 0 500 293 655 1 1
SPRED2 MAP2K2 0 0 94 190 1 1
SPRED2 FGF16 0 0 107 196 1 1
SPRED2 SPRY1 0 0 710 337 1 1
SPRED2 PTPN2 0 0 103 272 1 2
SPRED2 RNASEL 0 0 0 151 1 1
SPRED2 EVL 0 0 113 153 1 1
SPRED2 ADD1 0 0 0 224 1 1
SPRED2 RHEB 0 0 0 182 1 2
SPRED2 WIPF1 0 0 0 199 1 1
SPRED2 RRAS2 0 0 193 405 1 1
SPRED2 PSMA7 0 900 0 900 1 1
SPRED2 RAB14 0 0 0 171 1 1
SPRED2 NDEL1 0 0 0 188 1 1
SPRED2 TRIM67 0 0 0 213 1 1
SPRED2 MRPL45 0 0 141 164 1 1
SPRED2 PSMC3 0 900 0 900 1 1
SPRED2 RASAL2 0 500 108 552 1 1
SPRED2 MARK2 0 0 107 162 1 1
SPRED2 UBA52 0 900 0 900 1 1
SPRED2 CORO1B 0 0 95 299 1 1
SPRED2 FHL1 0 0 0 186 1 1
SPRED2 HOXC11 0 0 75 218 1 1
SPRED2 PTPRG 0 0 85 228 1 1
SPRED2 RPL34 0 0 97 153 1 1
SPRED2 SYK 0 0 0 184 1 2
SPRED2 RHOT2 0 0 0 158 1 1
SPRED2 PHF6 0 0 0 348 1 1
SPRED2 KIT 213 0 577 684 1 2
SPRED2 BHLHE41 0 0 63 161 1 1
SPRED2 NREP 0 0 211 211 1 1
SPRED2 COX20 0 0 142 181 1 1
SPRED2 SCEL 0 0 0 186 1 1
SPRED2 FEZ1 0 0 103 200 1 1
SPRED2 MMEL1 0 0 170 180 1 1
SPRED2 LGALSL 0 0 157 156 1 1
SPRED2 PTEN 0 0 111 152 1 2
SPRED2 CYFIP2 0 0 0 206 1 1
SPRED2 DSTYK 0 0 0 158 1 1
SPRED2 PFN2 0 0 73 333 1 1
SPRED2 LRCH3 0 0 60 155 1 1
SPRED2 MRAS 0 0 72 208 1 1
SPRED2 PSMB7 0 900 0 900 1 1
SPRED2 UBASH3A 0 0 162 180 1 1
SPRED2 FMN1 0 0 0 231 1 1
SPRED2 PSMB10 0 900 0 900 1 1
SPRED2 NAMPT 0 0 71 150 1 2
SPRED2 PTPRF 0 0 0 216 1 1
SPRED2 RBPJ 0 0 264 264 1 1
SPRED2 TJP1 0 0 48 196 1 1
SPRED2 PSMB11 0 900 0 900 1 1
SPRED2 EPHA6 0 0 0 188 1 1
SPRED2 DNAJB13 0 0 0 192 1 1
SPRED2 DIRAS2 0 0 0 182 1 1
SPRED2 HMP19 0 0 140 292 1 1
SPRED2 CTSD 270 0 0 270 1 2
SPRED2 CECR2 0 0 113 257 1 1
SPRED2 EZR 0 0 0 223 1 1
SPRED2 PRICKLE2 0 0 0 186 1 1
SPRED2 FLRT3 0 0 113 168 1 1
SPRED2 SSX2IP 0 0 0 260 1 1
SPRED2 PLEKHG4B 0 0 0 227 1 1
SPRED2 PTPN20A 0 0 73 181 1 1
SPRED2 RALA 0 0 90 258 1 1
SPRED2 PSMD14 0 900 0 900 1 1
SPRED2 GEM 0 0 0 203 1 1
SPRED2 AKT3 0 0 63 167 1 2
SPRED2 RASL11B 0 0 0 182 1 1
SPRED2 NEK2 0 0 0 261 1 1
SPRED2 RASL10A 0 0 0 182 1 1
SPRED2 RIPK4 0 0 0 158 1 1
SPRED2 STXBP4 0 0 0 154 1 1
SPRED2 DLX1 0 0 93 175 1 1
SPRED2 MYOZ1 0 0 89 151 1 1
SPRED2 PIAS3 0 0 125 204 1 1
SPRED2 UBC 0 900 0 900 1 2
SPRED2 ACTR3B 0 0 0 175 1 1
SPRED2 EHBP1 0 0 112 166 1 1
SPRED2 TRAM2 0 0 150 301 1 1
SPRED2 DUSP14 0 0 211 289 1 1
SPRED2 DLEU7 0 0 143 377 1 1
SPRED2 SMEK2 0 0 0 157 1 1
SPRED2 ARL13B 0 0 0 158 1 1
SPRED2 EPX 0 0 0 173 1 1
SPRED2 PXDNL 0 0 0 173 1 1
SPRED2 SMEK1 0 0 0 157 1 1
SPRED2 FPGT-TNNI3K 0 0 0 158 1 1
SPRED2 PTPN1 0 0 44 156 1 1
SPRED2 PLCD3 0 0 112 288 1 1
SPRED2 KSR1 0 0 60 161 1 1
SPRED2 WNT3A 0 0 61 154 1 2
SPRED2 PTPRA 0 0 0 199 1 1
SPRED2 FAM179A 0 0 294 294 1 1
SPRED2 TRIP6 0 0 87 339 1 1
SPRED2 IGDCC4 0 0 0 160 1 1
SPRED2 PSMC5 0 900 0 900 1 1
SPRED2 LYN 0 0 54 197 1 1
SPRED2 TMEM99 0 0 181 181 1 1
SPRED2 PSMD12 0 900 0 900 1 1
SPRED2 RAC1 0 0 0 171 1 2
SPRED2 IRF5 0 0 361 361 1 1
SPRED2 LIMCH1 0 0 0 186 1 1
SPRED2 PPP1CA 0 0 0 188 1 1
SPRED2 CTF1 0 0 136 226 1 1
SPRED2 SERBP1 0 0 94 232 1 1
SPRED2 NUAK1 0 0 141 188 1 1
SPRED2 TBX6 0 0 90 195 1 1
SPRED2 EOMES 0 0 53 157 1 1
SPRED2 LARP4 0 0 0 161 1 1
SPRED2 ARF6 0 0 0 158 1 1
SPRED2 ARL4C 0 0 0 158 1 1
SPRED2 RASL11A 0 0 0 182 1 1
SPRED2 STXBP1 0 0 0 202 1 1
SPRED2 ITGA2 0 0 0 228 1 1
SPRED2 DUSP1 0 0 139 169 1 1
SPRED2 FLT4 0 0 103 217 1 1
SPRED2 PRKCH 0 0 87 178 1 1
SPRED2 MET 0 0 56 150 1 2
SPRED2 PPM1A 0 0 0 163 1 1
SPRED2 LRRK2 0 0 0 158 1 2
SPRED2 ENOX1 0 0 201 201 1 1
SPRED2 RASL10B 0 0 0 182 1 1
SPRED2 PSMD9 0 900 0 900 1 1
SPRED2 REM2 0 0 0 182 1 1
SPRED2 PSMD2 0 900 0 900 1 1
SPRED2 RHOBTB3 0 0 0 171 1 1
SPRED2 PSME2 0 900 0 900 1 1
SPRED2 RHOD 0 0 0 171 1 1
SPRED2 DUSP27 0 0 112 162 1 1
SPRED2 WIPF2 0 0 61 216 1 1
SPRED2 AJUBA 0 0 0 174 1 1
SPRED2 PKP4 0 0 54 174 1 1
SPRED2 GAB1 0 0 0 309 1 1
SPRED2 PTPN18 0 0 162 287 1 1
SPRED2 PTPN11 0 0 203 369 1 1
SPRED2 TNIP1 0 0 161 161 1 1
SPRED2 RAB11B 0 0 0 158 1 1
SPRED2 FGF20 0 0 82 156 1 1
SPRED2 NRAS 0 600 118 756 1 1
SPRED2 DCC 0 0 0 160 1 1
SPRED2 SEC11A 0 0 165 165 1 1
SPRED2 C12orf43 0 0 248 329 1 1
SPRED2 RAB39B 0 0 0 158 1 1
SPRED2 KRAS 169 600 94 812 1 2
SPRED2 ZIC3 0 0 81 172 1 1
SPRED2 RND2 0 0 0 171 1 1
SPRED2 SOCS2 0 0 169 196 1 1
SPRED2 DUX4 0 0 151 150 1 1
SPRED2 EPHA3 0 0 0 188 1 1
SPRED2 RPS27A 0 900 0 901 1 1
SPRED2 FGF8 0 0 154 176 1 1
SPRED2 SIK1 0 0 123 212 1 1
SPRED2 BLK 0 0 242 313 1 1
SPRED2 PFN1 0 0 62 325 1 1
SPRED2 CUL3 0 900 48 904 1 2
SPRED2 EPHB2 0 0 0 188 1 2
SPRED2 RAB2B 0 0 0 158 1 1
SPRED2 PRTFDC1 130 0 73 184 1 1
SPRED2 WTIP 0 0 0 174 1 1
SPRED2 RASA2 0 500 180 581 1 1
SPRED2 ATG16L1 0 0 96 173 1 2
SPRED2 C6orf106 0 0 67 210 1 1
SPRED2 USE1 0 0 0 158 1 1
SPRED2 RAB42 0 0 0 158 1 1
SPRED2 MAP3K10 0 0 0 158 1 1
SPRED2 RIPK1 0 0 45 161 1 2
SPRED2 PSMD3 0 900 0 900 1 1
SPRED2 REL 0 0 140 158 1 2
SPRED2 PSMB6 0 900 0 917 1 1
SPRED2 WFIKKN2 0 0 57 152 1 1
SPRED2 LMO7 0 0 0 194 1 1
SPRED2 TNNI3K 0 0 0 158 1 1
SPRED2 PSMB9 0 900 0 909 1 1
SPRED2 PTGS2 0 0 48 179 1 2
SPRED2 CYP26A1 0 0 54 155 1 1
SPRED2 EPHA5 0 0 141 272 1 1
SPRED2 WASF2 0 0 0 238 1 1
SPRED2 RAB4B 0 0 0 158 1 1
SPRED2 LIMS3 0 0 0 174 1 1
SPRED2 LIMS1 0 0 0 174 1 1
SPRED2 PPM1B 0 0 0 160 1 1
SPRED2 FGFRL1 0 600 0 622 1 1
SPRED2 RPL31 0 0 0 225 1 1
SPRED2 PSMA5 0 900 0 902 1 1
SPRED2 PRKCQ 0 0 193 214 1 2
SPRED2 LIMS3L 0 0 0 174 1 1
SPRED2 VPS13A 0 0 0 224 1 1
SPRED2 VEGFC 0 0 142 232 1 1
SPRED2 PSMC4 0 900 0 900 1 1
SPRED2 ENSG00000268643 0 0 0 158 1 1
SPRED2 DIRAS3 0 0 0 182 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005515 Molecular Function protein binding enables IPI
GO:0019901 Molecular Function protein kinase binding enables IBA
GO:0019901 Molecular Function protein kinase binding enables IPI
GO:0030291 Molecular Function protein serine/threonine kinase inhibitor activity enables ISS
GO:0005173 Molecular Function stem cell factor receptor binding enables ISS
GO:0070373 Biological Process negative regulation of ERK1 and ERK2 cascade involved_in ISS
GO:0043409 Biological Process negative regulation of MAPK cascade involved_in IBA
GO:0043409 Biological Process negative regulation of MAPK cascade acts_upstream_of_or_within ISS
GO:0010719 Biological Process negative regulation of epithelial to mesenchymal transition involved_in ISS
GO:1902747 Biological Process negative regulation of lens fiber cell differentiation involved_in ISS
GO:0010801 Biological Process negative regulation of peptidyl-threonine phosphorylation involved_in IMP
GO:0030512 Biological Process negative regulation of transforming growth factor beta receptor signaling pathway involved_in ISS
GO:0043517 Biological Process positive regulation of DNA damage response, signal transduction by p53 class mediator involved_in ISS
GO:0090311 Biological Process regulation of protein deacetylation involved_in ISS
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005886 Cellular Component plasma membrane located_in IEA
GO:0030658 Cellular Component transport vesicle membrane located_in IEA
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Disease Reactome R-HSA-1643685
Signaling by FGFR Reactome R-HSA-190236
Signaling by FGFR1 Reactome R-HSA-5654736
Regulation of RAS by GAPs Reactome R-HSA-5658442
FGFRL1 modulation of FGFR1 signaling Reactome R-HSA-5658623
Diseases of signal transduction by growth factor receptors and second messengers Reactome R-HSA-5663202
RAF/MAP kinase cascade Reactome R-HSA-5673001
MAPK family signaling cascades Reactome R-HSA-5683057
MAPK1/MAPK3 signaling Reactome R-HSA-5684996
RAS signaling downstream of NF1 loss-of-function variants Reactome R-HSA-6802953
Oncogenic MAPK signaling Reactome R-HSA-6802957
Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
Imatinib and chronic myeloid leukemia (WP3640) WikiPathways WP3640_r122579
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_005264202 6 mRNA transcript variant X6 NC_000002 Reference
XM_005264200 6 mRNA transcript variant X3 NC_000002 Reference
XM_047443712 1 mRNA transcript variant X7 NC_000002 Reference
XM_047443710 1 mRNA transcript variant X4 NC_000002 Reference
NM_181784 3 mRNA transcript variant 1 NC_000002 Reference
XM_047443709 1 mRNA transcript variant X1 NC_000002 Reference
NM_001128210 2 mRNA transcript variant 2 NC_000002 Reference
XM_047443711 1 mRNA transcript variant X5 NC_000002 Reference
XM_017003576 2 mRNA transcript variant X2 NC_000002 Reference