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USP12

ubiquitin specific peptidase 12
General Information
Name ubiquitin specific peptidase 12
Alias
  • ubiquitin carboxyl-terminal hydrolase 12
  • deubiquitinating enzyme 12
  • ubiquitin specific protease 12 like 1
  • ubiquitin thioesterase 12
  • ubiquitin thiolesterase 12
  • ubiquitin-hydrolyzing enzyme 1
  • ubiquitin-specific-processing protease 12
Gene_family Ubiquitin specific peptidases
organism Homo sapiens
entrez_id 219333
location 13q12.13
transcript_count 2
exon_count 9
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Enables cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability; Belongs to the peptidase C19 family. USP12/USP46 subfamily
    nextProt Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
USP12 BioGRID USP46 GeneID BioGRID Affinity Capture-MS; Negative Genetic; Proximity Label-MS
USP12 BioGRID MMP14 GeneID BioGRID Affinity Capture-Western
USP12 BioGRID BAX GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
USP12 BioGRID RAF1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID CDC73 GeneID BioGRID Reconstituted Complex; Two-hybrid
USP12 BioGRID MDK GeneID BioGRID Affinity Capture-Western
USP12 BioGRID HMGB1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
USP12 BioGRID CLASP2 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID VSX1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID PPM1B GeneID BioGRID Affinity Capture-Western
USP12 BioGRID EP300 GeneID BioGRID Affinity Capture-Western
USP12 BioGRID TSPYL6 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID VSX2 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID SGO1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID RNF19B GeneID BioGRID Affinity Capture-MS
USP12 BioGRID HSPB9 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID OPALIN GeneID BioGRID Affinity Capture-MS
USP12 BioGRID WDR20 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; Proximity Label-MS; Two-hybrid
USP12 BioGRID GORASP1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID IGDCC4 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID HSPB8 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID GPR161 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID PHF8 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID PNMA2 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID RAD51AP1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS
USP12 BioGRID YWHAG GeneID BioGRID Affinity Capture-MS
USP12 BioGRID YWHAB GeneID BioGRID Affinity Capture-MS
USP12 BioGRID CX3CL1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID CD6 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID WDR48 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Co-localization; Proximity Label-MS; Reconstituted Complex
USP12 BioGRID USP1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID NMRAL1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID HNRNPH1 GeneID BioGRID Affinity Capture-RNA
USP12 BioGRID ILF3 GeneID BioGRID Proximity Label-MS
USP12 BioGRID DCAF4 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID MAVS GeneID BioGRID Affinity Capture-Western
USP12 BioGRID MDM2 GeneID BioGRID Affinity Capture-Western
USP12 BioGRID PHLPP1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS
USP12 BioGRID PHLPP2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
USP12 BioGRID AR GeneID BioGRID Affinity Capture-Western
USP12 BioGRID ITCH GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
USP12 BioGRID TRAT1 GeneID BioGRID Proximity Label-MS
USP12 BioGRID LAT GeneID BioGRID Proximity Label-MS
USP12 BioGRID ZAP70 GeneID BioGRID Proximity Label-MS
USP12 BioGRID GRB2 GeneID BioGRID Proximity Label-MS
USP12 BioGRID CBLB GeneID BioGRID Proximity Label-MS
USP12 BioGRID NOTCH1 GeneID BioGRID Biochemical Activity
USP12 BioGRID UBC GeneID BioGRID Reconstituted Complex
USP12 BioGRID APP GeneID BioGRID Reconstituted Complex
USP12 BioGRID WDR26 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID WDR77 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID H2BC21 GeneID BioGRID Biochemical Activity
USP12 BioGRID H2AC20 GeneID BioGRID Biochemical Activity
USP12 BioGRID DMWD GeneID BioGRID Affinity Capture-MS
USP12 BioGRID PAIP1 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID MMP2 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID DHX8 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID UCHL5 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID SDF4 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID NUP160 GeneID BioGRID Affinity Capture-MS
USP12 BioGRID USP39 GeneID BioGRID Affinity Capture-MS
StringDB
A B experiments database textmining combined score hadb nhadb
USP12 USP54 0 0 391 429 1 1
USP12 TXK 0 0 0 185 1 1
USP12 FAM63A 0 0 193 193 1 1
USP12 PFKFB2 0 0 0 156 1 1
USP12 CUL2 0 0 109 183 1 1
USP12 SIAH2 0 0 218 252 1 1
USP12 CTSA 0 0 143 176 1 1
USP12 USP17L26 0 0 468 215 1 1
USP12 MDM2 270 0 286 472 1 2
USP12 TP53 0 0 202 216 1 2
USP12 UBIAD1 0 0 54 159 1 1
USP12 USP37 0 0 502 258 1 1
USP12 NEDD8 0 0 172 190 1 2
USP12 UCHL5 131 0 452 620 1 1
USP12 PRPF31 0 0 108 182 1 1
USP12 RPN1 0 0 0 208 1 1
USP12 CMSS1 0 0 216 216 1 1
USP12 MKRN1 0 0 134 370 1 1
USP12 UBR5 0 0 94 370 1 1
USP12 SLC13A5 0 0 167 167 1 1
USP12 USP17L29 0 0 468 215 1 1
USP12 GABPB2 0 0 214 280 1 1
USP12 EML2 0 0 0 211 1 1
USP12 HSPA12B 0 0 139 456 1 1
USP12 EML6 0 0 0 211 1 1
USP12 FBXL15 0 0 207 221 1 1
USP12 G3BP2 0 0 193 250 1 1
USP12 HUWE1 0 0 137 180 1 1
USP12 SENP5 0 0 95 151 1 1
USP12 MED23 0 0 61 221 1 1
USP12 ANKRD42 0 0 0 172 1 1
USP12 PSMD10 0 0 87 380 1 1
USP12 UBE4A 0 0 90 351 1 1
USP12 EIF3H 0 0 294 416 1 1
USP12 RNF168 0 0 161 161 1 1
USP12 USP15 0 0 504 281 1 1
USP12 KLHL21 0 0 151 164 1 1
USP12 LBR 0 0 204 213 1 1
USP12 USP10 0 0 0 214 1 1
USP12 CCDC8 0 0 135 158 1 1
USP12 KLB 0 0 0 161 1 1
USP12 MYC 0 0 174 217 1 2
USP12 HIPK1 0 0 0 215 1 1
USP12 UBE2H 0 0 234 299 1 1
USP12 IGF1R 0 0 0 157 1 2
USP12 UBE2D1 0 0 141 180 1 1
USP12 BTBD9 0 0 134 159 1 1
USP12 ADNP 0 0 90 501 1 1
USP12 FBXW8 0 0 115 188 1 1
USP12 CAB39 0 0 0 239 1 1
USP12 USP17L1P 0 0 267 154 1 1
USP12 UBE2K 0 0 48 172 1 1
USP12 PRR11 0 0 156 155 1 1
USP12 EML4 0 0 0 211 1 1
USP12 KIF20B 0 0 0 207 1 1
USP12 USP39 131 0 341 575 1 1
USP12 GRIN3B 0 0 0 154 1 1
USP12 USP38 0 0 358 184 1 1
USP12 PSMA6 0 0 0 187 1 1
USP12 BRCA1 0 0 120 157 1 2
USP12 MAGI1 0 0 0 161 1 1
USP12 MEF2D 0 0 70 324 1 2
USP12 PDZRN4 0 0 0 207 1 1
USP12 UBA1 0 0 113 152 1 1
USP12 HIPK4 0 0 0 215 1 1
USP12 FBXL16 0 0 210 224 1 1
USP12 CEP97 0 0 150 168 1 1
USP12 GRIA4 0 0 0 365 1 1
USP12 RRN3 0 0 0 248 1 1
USP12 GRIA2 0 0 45 368 1 1
USP12 KLK2 0 0 143 150 1 1
USP12 PRPF4 0 0 137 155 1 1
USP12 NPEPPS 0 0 0 189 1 1
USP12 HSPB6 0 0 81 321 1 1
USP12 TRIP12 0 0 0 492 1 1
USP12 GRIK2 0 0 0 154 1 1
USP12 KLF3 0 0 63 163 1 1
USP12 USP43 0 0 506 322 1 1
USP12 UBE2B 0 0 97 169 1 1
USP12 TANC1 0 0 60 242 1 1
USP12 PPAPDC1A 0 0 155 208 1 1
USP12 UBE2D3 0 0 143 168 1 1
USP12 PSMB1 0 0 90 446 1 1
USP12 WDR3 0 0 151 233 1 1
USP12 PRSS16 0 0 134 153 1 1
USP12 PSMA1 0 0 154 301 1 1
USP12 TRIM9 0 0 141 374 1 1
USP12 BAP1 0 0 92 241 1 1
USP12 USP44 0 0 469 231 1 1
USP12 HIST2H2AC 270 0 325 492 1 1
USP12 WWP1 0 0 67 297 1 1
USP12 BIRC2 0 0 82 277 1 1
USP12 USP9X 0 0 325 232 1 1
USP12 RNF6 0 0 324 511 1 1
USP12 KSR2 0 0 0 208 1 1
USP12 DUSP5 0 0 57 238 1 1
USP12 USP47 0 0 465 303 1 1
USP12 ACSS2 0 0 0 160 1 1
USP12 USP17L28 0 0 468 215 1 1
USP12 USP27X 0 0 343 226 1 1
USP12 PHLPP1 750 0 491 875 1 2
USP12 USP45 0 0 359 282 1 1
USP12 ZRANB1 0 0 390 448 1 1
USP12 NFKB1 0 0 0 157 1 2
USP12 PARP11 0 0 134 219 1 1
USP12 WDR26 270 0 0 270 1 1
USP12 POLH 0 0 0 166 1 1
USP12 NEDD4 0 0 222 399 1 2
USP12 HIF1A 0 0 241 241 1 2
USP12 FBXL12 0 0 150 165 1 1
USP12 USP41 0 0 369 232 1 1
USP12 NDRG1 0 0 75 168 1 1
USP12 UBE2R2 0 0 126 276 1 1
USP12 RIBC1 0 0 286 286 1 1
USP12 SART3 0 0 234 265 1 1
USP12 SUMO2 0 0 113 192 1 1
USP12 OTUD3 0 0 212 246 1 1
USP12 UBE2G1 0 0 106 165 1 1
USP12 GRIK3 0 0 0 154 1 1
USP12 BRWD3 0 0 0 228 1 1
USP12 MYSM1 0 0 391 494 1 1
USP12 CLK3 0 0 0 214 1 1
USP12 GPR37 0 0 0 206 1 1
USP12 TBL1XR1 0 0 81 260 1 1
USP12 USP17L27 0 0 468 215 1 1
USP12 UBE2A 0 0 233 280 1 1
USP12 MARK4 0 0 0 254 1 1
USP12 USP21 0 0 503 254 1 1
USP12 RRH 0 0 0 215 1 1
USP12 NOTCH1 270 0 93 354 1 2
USP12 PSMB4 0 0 90 152 1 1
USP12 SMARCAD1 0 0 0 198 1 1
USP12 USP42 0 0 344 207 1 1
USP12 MBD3 0 0 0 153 1 1
USP12 AR 675 600 292 899 1 2
USP12 RAD51AP1 488 0 167 599 1 1
USP12 USP33 0 0 458 264 1 1
USP12 UBE2L3 0 0 167 203 1 1
USP12 HNRNPH1 270 0 0 270 1 1
USP12 VSX2 422 0 0 422 1 1
USP12 NDUFAF6 0 0 140 271 1 1
USP12 UBE2N 0 0 95 169 1 1
USP12 GABPB1 0 0 90 167 1 1
USP12 IFT122 0 0 0 211 1 1
USP12 USP6 0 0 261 216 1 1
USP12 UBE2G2 0 0 95 170 1 1
USP12 WDR48 975 800 987 999 1 1
USP12 WDR38 0 0 0 249 1 1
USP12 USP16 0 0 0 184 1 1
USP12 NMD3 0 0 108 188 1 1
USP12 RNF8 0 0 150 184 1 1
USP12 FBXW7 0 0 108 388 1 2
USP12 MARS2 0 0 0 187 1 1
USP12 HIST2H2AA3 0 0 327 335 1 1
USP12 HSP90AA1 0 0 73 273 1 2
USP12 UFD1L 0 0 122 156 1 1
USP12 TBL2 0 0 0 211 1 1
USP12 C4orf19 0 0 0 187 1 1
USP12 DYRK2 0 0 81 339 1 1
USP12 RFFL 0 0 134 152 1 1
USP12 STUB1 0 0 234 253 1 2
USP12 GBP7 0 0 135 151 1 1
USP12 HIST2H2AA 0 0 327 335 1 1
USP12 USP17L2 0 0 504 226 1 1
USP12 CERKL 0 0 0 161 1 1
USP12 UBE2E1 0 0 154 160 1 1
USP12 ACTB 0 0 82 164 1 2
USP12 WHSC1L1 0 0 135 178 1 1
USP12 SQSTM1 0 0 0 189 1 2
USP12 MPND 0 0 362 464 1 1
USP12 BRCC3 0 0 334 440 1 1
USP12 RANBP9 0 0 150 282 1 1
USP12 DNAJC9 0 0 0 207 1 1
USP12 ALG13 0 0 150 293 1 1
USP12 GPR161 184 0 0 183 1 1
USP12 USP35 0 0 414 210 1 1
USP12 USP17L30 0 0 468 215 1 1
USP12 ENSG00000268434 0 0 0 606 1 1
USP12 CDC20 0 0 59 226 1 1
USP12 WDR33 0 0 0 228 1 1
USP12 TRIM17 0 0 96 202 1 1
USP12 GRIN2C 0 0 0 154 1 1
USP12 DNAJC16 0 0 181 404 1 1
USP12 PARD3B 0 0 134 173 1 1
USP12 ASB13 0 0 59 194 1 1
USP12 TNIP3 0 0 96 152 1 1
USP12 HIP1 0 0 0 156 1 1
USP12 GRIN2A 0 0 0 154 1 1
USP12 SPOP 0 0 179 208 1 1
USP12 WDFY2 0 0 0 228 1 1
USP12 CETN2 0 0 134 155 1 1
USP12 BMI1 0 0 134 182 1 1
USP12 TBL1X 0 0 48 234 1 1
USP12 USP4 0 0 457 267 1 1
USP12 MIB2 0 0 0 272 1 1
USP12 UBE2F 0 0 134 188 1 1
USP12 SLC16A14 0 0 46 211 1 1
USP12 OTUD4 0 0 321 439 1 1
USP12 ANKRD44 0 0 0 150 1 1
USP12 UCHL1 0 0 317 469 1 2
USP12 WDFY1 0 0 0 228 1 1
USP12 USP50 0 0 426 228 1 1
USP12 LGALS7B 0 0 75 248 1 1
USP12 GRIN2D 0 0 66 176 1 1
USP12 FZR1 0 0 0 211 1 1
USP12 USP40 0 0 281 254 1 1
USP12 OTUD6B 0 0 371 586 1 1
USP12 FBXO36 0 0 245 411 1 1
USP12 WRAP53 0 0 81 157 1 1
USP12 USP24 0 0 340 283 1 1
USP12 SKP2 0 0 113 278 1 2
USP12 BTG3 0 0 194 194 1 1
USP12 USP36 0 0 392 222 1 1
USP12 KLF5 0 0 282 282 1 2
USP12 OTUB1 0 0 391 481 1 1
USP12 RCSD1 0 0 0 553 1 1
USP12 TANGO2 0 0 0 186 1 1
USP12 ENY2 0 0 203 222 1 1
USP12 FAM188B 0 0 181 181 1 1
USP12 H2AFZ 0 0 157 177 1 1
USP12 SRPK1 0 0 0 181 1 1
USP12 UBE4B 0 0 81 259 1 1
USP12 USP22 0 0 517 240 1 1
USP12 DYRK3 0 0 0 215 1 1
USP12 USP29 0 0 372 235 1 1
USP12 FAM188A 0 0 157 156 1 1
USP12 ZUFSP 0 0 241 240 1 1
USP12 TRIM55 0 0 0 214 1 1
USP12 CLSPN 0 0 112 170 1 1
USP12 NWD2 0 0 0 211 1 1
USP12 THSD1 0 0 167 167 1 1
USP12 PAN2 0 0 379 465 1 1
USP12 FIP1L1 0 0 0 156 1 1
USP12 ASNSD1 0 0 0 274 1 1
USP12 IGSF8 0 0 96 191 1 1
USP12 ARL11 0 0 171 171 1 1
USP12 OTUD6A 0 0 341 567 1 1
USP12 NFXL1 0 0 193 268 1 1
USP12 HCFC1 0 0 134 380 1 1
USP12 BIRC3 0 0 75 268 1 1
USP12 BRWD1 0 0 0 228 1 1
USP12 RNF123 0 0 163 361 1 1
USP12 OTULIN 0 0 213 222 1 1
USP12 CDC23 0 0 0 190 1 1
USP12 UCHL3 0 0 414 672 1 1
USP12 PLEKHO1 0 0 119 256 1 1
USP12 LGALS7 0 0 75 248 1 1
USP12 ERI1 0 0 0 222 1 1
USP12 USP28 0 0 427 630 1 1
USP12 CUL1 0 0 204 269 1 1
USP12 FANCM 0 0 74 153 1 1
USP12 FKBP5 0 0 134 193 1 1
USP12 USP17L24 0 0 468 215 1 1
USP12 PSMA4 0 0 95 257 1 1
USP12 MAVS 270 0 0 322 1 2
USP12 MAGI3 0 0 0 173 1 1
USP12 KIF20A 0 0 0 207 1 1
USP12 SPAST 0 0 71 171 1 1
USP12 RNF19B 130 0 0 167 1 1
USP12 YWHAG 131 0 0 176 1 1
USP12 USP32 0 0 460 296 1 1
USP12 ANKRD11 0 0 124 216 1 1
USP12 EML5 0 0 0 211 1 1
USP12 OTUB2 0 0 325 385 1 1
USP12 VCPIP1 0 0 326 444 1 1
USP12 C14orf2 0 0 193 193 1 1
USP12 KLHL25 0 0 184 196 1 1
USP12 TIMM10 0 0 122 214 1 1
USP12 WDR77 270 0 90 442 1 1
USP12 UBL4A 0 0 113 189 1 1
USP12 WDR37 0 0 0 211 1 1
USP12 HTATSF1 0 0 0 165 1 1
USP12 HIST2H2BE 270 0 420 566 1 1
USP12 RNF215 0 0 0 186 1 1
USP12 RFWD2 0 0 0 211 1 1
USP12 CCDC94 0 0 244 261 1 1
USP12 FANCI 0 0 261 343 1 1
USP12 PSMA3 0 0 90 152 1 1
USP12 CLK1 0 0 0 214 1 1
USP12 BARD1 0 0 96 230 1 1
USP12 UBB 800 0 0 813 1 1
USP12 CDIPT 0 0 0 256 1 1
USP12 SSBP1 0 0 0 169 1 1
USP12 MAGI2 0 0 0 161 1 1
USP12 GRIK5 0 0 0 154 1 1
USP12 CFAP44 0 0 0 211 1 1
USP12 GRIA1 0 0 46 369 1 1
USP12 PID1 0 0 122 264 1 1
USP12 USP13 0 0 400 623 1 1
USP12 PHLPP2 826 0 401 897 1 1
USP12 SMYD4 0 0 150 296 1 1
USP12 REEP4 0 0 182 236 1 1
USP12 UBFD1 0 0 0 213 1 1
USP12 GRID1 0 0 0 154 1 2
USP12 EML1 0 0 0 211 1 1
USP12 FBXL18 0 0 171 297 1 1
USP12 ITCH 299 0 113 569 1 1
USP12 USP14 0 0 557 361 1 2
USP12 RRS1 0 0 122 212 1 1
USP12 SHPRH 0 0 0 151 1 1
USP12 PNPLA6 0 0 103 181 1 1
USP12 MAK16 0 0 172 223 1 1
USP12 UBL3 0 0 143 202 1 1
USP12 NAIP 0 0 0 153 1 1
USP12 ASCC1 0 0 0 196 1 1
USP12 HIPK3 0 0 0 230 1 1
USP12 USP5 0 0 421 304 1 1
USP12 ELP2 0 0 46 165 1 1
USP12 HSPA13 0 0 117 445 1 1
USP12 NBR1 0 0 0 201 1 2
USP12 C1orf61 0 0 171 171 1 1
USP12 RNF4 0 0 134 154 1 1
USP12 TAF5 0 0 0 230 1 1
USP12 GRIA3 0 0 0 365 1 1
USP12 NEDD4L 0 0 91 298 1 1
USP12 PRPF8 0 0 215 341 1 1
USP12 USP19 0 0 392 283 1 1
USP12 FBXW2 0 0 108 210 1 1
USP12 HECW1 0 0 76 160 1 1
USP12 USP26 0 500 619 646 1 1
USP12 TNFAIP3 0 0 241 316 1 2
USP12 BYSL 0 0 103 180 1 1
USP12 NFKB2 0 0 54 151 1 1
USP12 U2AF2 0 0 0 428 1 1
USP12 FANCD2 0 0 390 529 1 1
USP12 FBXL17 0 0 162 176 1 1
USP12 USP53 0 0 296 306 1 1
USP12 DPH5 0 0 60 346 1 1
USP12 USP25 0 0 365 590 1 1
USP12 BIRC8 0 0 0 153 1 1
USP12 CYLD 0 0 325 343 1 1
USP12 GRIK4 0 0 0 154 1 1
USP12 BIRC5 0 0 0 153 1 2
USP12 USP3 0 0 509 199 1 1
USP12 OTUD7A 0 0 297 345 1 1
USP12 REG4 0 0 95 151 1 1
USP12 ASNS 0 0 0 177 1 1
USP12 XIAP 0 0 48 159 1 2
USP12 USP46 659 0 920 685 1 1
USP12 FBXL14 0 0 215 228 1 1
USP12 ENSG00000279392 0 0 167 203 1 1
USP12 CDK8 0 0 150 169 1 1
USP12 WDR78 0 0 0 228 1 1
USP12 UBTD1 0 0 216 251 1 1
USP12 B9D1 0 0 0 181 1 1
USP12 NUDT12 0 0 0 205 1 1
USP12 ZNF691 0 0 256 261 1 1
USP12 HSPH1 0 0 0 202 1 1
USP12 UBA5 0 0 123 189 1 1
USP12 GRIK1 0 0 0 154 1 1
USP12 UBLCP1 0 0 0 216 1 1
USP12 UBE3A 0 0 218 273 1 1
USP12 WDR20 870 800 832 998 1 1
USP12 AKT1 0 0 145 196 1 2
USP12 UBR1 0 0 165 323 1 1
USP12 USP7 0 0 601 313 1 1
USP12 CLK4 0 0 0 214 1 1
USP12 TEP1 0 0 0 228 1 1
USP12 HID1 0 0 0 252 1 1
USP12 TAF1D 0 0 310 325 1 1
USP12 DDB1 0 0 60 222 1 1
USP12 HACE1 0 0 58 195 1 1
USP12 TAF5L 0 0 0 230 1 1
USP12 RNF2 0 0 150 158 1 1
USP12 SKP1 0 0 107 162 1 2
USP12 USP1 0 0 710 323 1 1
USP12 NWD1 0 0 0 228 1 1
USP12 WASF1 0 0 67 455 1 1
USP12 RNF167 0 0 57 324 1 1
USP12 GIMAP2 0 0 66 158 1 1
USP12 USP17L25 0 0 468 215 1 1
USP12 FBXL13 0 0 161 175 1 1
USP12 MYO1E 0 0 0 176 1 1
USP12 UBE2C 0 0 112 151 1 1
USP12 KLHL7 0 0 62 171 1 1
USP12 YOD1 0 0 274 593 1 1
USP12 WWP2 0 0 48 283 1 1
USP12 PSMD7 0 0 298 426 1 1
USP12 FBXW11 0 0 123 167 1 1
USP12 CADM1 0 0 153 153 1 1
USP12 GMPS 0 0 207 273 1 1
USP12 BIRC6 0 0 0 183 1 1
USP12 TP53I11 0 0 123 210 1 1
USP12 ATAD5 0 0 234 382 1 1
USP12 USP8 0 0 519 260 1 1
USP12 SMURF2 0 0 122 408 1 1
USP12 STAMBP 0 0 282 340 1 1
USP12 PRPF4B 0 0 0 181 1 1
USP12 DAP3 0 0 135 158 1 1
USP12 DNAJC5 0 0 0 156 1 1
USP12 USP2 0 0 468 246 1 1
USP12 STAMBPL1 0 0 247 308 1 1
USP12 RPS27A 800 0 0 804 1 1
USP12 CDC34 0 0 155 318 1 1
USP12 HIP1R 0 0 0 156 1 1
USP12 GRIN3A 0 0 46 186 1 1
USP12 APBB2 0 0 0 165 1 1
USP12 FBXL7 0 0 130 168 1 1
USP12 CUL3 0 0 140 388 1 2
USP12 DTL 0 0 82 194 1 1
USP12 JOSD2 0 0 464 613 1 1
USP12 SLC4A1 0 0 193 253 1 1
USP12 UBE2L6 0 0 95 155 1 1
USP12 GPI 0 0 0 169 1 2
USP12 COPS8 0 0 134 193 1 1
USP12 CTSZ 0 0 0 228 1 1
USP12 LNX1 0 0 0 153 1 1
USP12 BRCA2 0 0 86 350 1 1
USP12 PSMB6 0 0 165 280 1 1
USP12 SMURF1 0 0 0 262 1 1
USP12 USP11 0 0 501 279 1 2
USP12 PPM1B 0 0 0 150 1 1
USP12 TONSL 0 0 0 158 1 1
USP12 SRPK3 0 0 0 181 1 1
USP12 USP48 0 0 371 231 1 1
USP12 CDC20B 0 0 0 211 1 1
USP12 OTUD7B 0 0 342 387 1 1
USP12 RASL11A 0 0 282 282 1 1
USP12 USP51 0 0 423 197 1 1
USP12 USP49 0 0 507 247 1 1
USP12 PHIP 0 0 0 228 1 1
USP12 AGBL5 0 0 53 168 1 1
USP12 DNAJC10 0 0 95 405 1 1
USP12 PPM1A 0 0 0 150 1 1
USP12 PICK1 0 0 0 258 1 1
USP12 ATXN3 0 0 253 302 1 2
USP12 GRIN2B 0 0 0 171 1 1
USP12 USP20 0 0 420 244 1 1
USP12 RNF20 0 0 213 244 1 1
USP12 GRID2 0 0 0 154 1 2
USP12 UBE2E3 0 0 142 193 1 1
USP12 PPM1N 0 0 0 150 1 1
USP12 IGSF6 0 0 122 218 1 1
USP12 ANKRD32 0 0 0 178 1 1
USP12 WDR59 0 0 0 230 1 1
USP12 TMUB1 0 0 66 293 1 1
USP12 BIRC7 0 0 0 185 1 1
USP12 SPATA2L 0 0 277 277 1 1
USP12 COPS6 0 0 210 274 1 1
USP12 SRPK2 0 0 0 181 1 1
USP12 DYNAP 0 0 295 295 1 1
USP12 WDR17 0 0 0 228 1 1
USP12 BTRC 0 0 214 224 1 1
USP12 PICALM 0 0 0 162 1 1
USP12 UEVLD 0 0 202 207 1 1
USP12 TPTE2 0 0 163 191 1 1
USP12 PSMD14 0 0 338 553 1 1
USP12 PARD6B 0 0 386 399 1 1
USP12 EML3 0 0 0 211 1 1
USP12 FANCL 0 0 60 150 1 1
USP12 ODF1 0 0 108 400 1 1
USP12 ATXN3L 0 0 370 411 1 1
USP12 OTUD1 0 0 321 363 1 1
USP12 CLK2 0 0 0 214 1 1
USP12 URB2 0 0 180 307 1 1
USP12 UBE3B 0 0 134 214 1 1
USP12 ISG15 0 0 138 172 1 2
USP12 UBC 847 0 124 870 1 2
USP12 EIF2A 0 0 109 470 1 2
USP12 MYO1F 0 0 0 176 1 1
USP12 SUGT1 0 0 150 181 1 1
USP12 USP18 0 0 333 222 1 1
USP12 USP30 0 0 423 279 1 1
USP12 UBE2J2 0 0 122 205 1 1
USP12 MSL2 0 0 132 157 1 1
USP12 DMWD 413 0 289 821 1 1
USP12 DYRK1A 0 0 0 215 1 1
USP12 HIPK2 0 0 0 215 1 2
USP12 TANC2 0 0 0 164 1 1
USP12 NUP160 131 0 0 159 1 1
USP12 UFM1 0 0 0 165 1 1
USP12 TSR1 0 0 109 197 1 1
USP12 GNB1L 0 0 0 211 1 1
USP12 MIB1 0 0 0 272 1 1
USP12 UBE2Q1 0 0 129 206 1 1
USP12 KSR1 0 0 0 208 1 1
USP12 WDR18 0 0 0 211 1 1
USP12 TSPYL6 145 0 0 163 1 1
USP12 SENP3 0 0 91 172 1 1
USP12 COPS5 0 0 294 395 1 1
USP12 PSMD12 0 0 0 157 1 1
USP12 TP53BP1 0 0 113 168 1 1
USP12 GMIP 0 0 173 188 1 1
USP12 PDZRN3 0 0 143 601 1 1
USP12 IFT80 0 0 0 211 1 1
USP12 DIMT1 0 0 150 259 1 1
USP12 FAM63B 0 0 206 206 1 1
USP12 UBA52 800 0 0 807 1 1
USP12 YDJC 0 0 193 193 1 1
USP12 UIMC1 0 0 183 183 1 1
USP12 ZBTB12 0 0 204 395 1 1
USP12 NFKBIA 0 0 92 197 1 2
USP12 COMMD3-BMI1 0 0 136 184 1 1
USP12 S1PR1 0 0 0 189 1 1
USP12 RNF14 0 0 180 197 1 1
USP12 SENP8 0 0 170 227 1 1
USP12 DYRK4 0 0 0 220 1 1
USP12 PTEN 0 0 86 205 1 2
USP12 RPL10A 0 0 74 327 1 1
USP12 HECW2 0 0 150 227 1 1
USP12 JOSD1 0 0 390 514 1 1
USP12 UBE2S 0 0 75 197 1 1
USP12 UPP2 0 0 151 150 1 1
USP12 VWA1 0 0 0 157 1 1
USP12 TRAT1 114 0 211 271 1 1
USP12 OTUD5 0 0 295 431 1 1
USP12 USP34 0 0 186 215 1 1
USP12 DHX8 131 0 0 150 1 1
USP12 DYRK1B 0 0 0 215 1 1
USP12 DNAJC5B 0 0 171 382 1 1
USP12 TTC28 0 0 184 183 1 1
USP12 TRIM54 0 0 0 214 1 1
USP12 MDM4 0 0 54 339 1 1
USP12 TRIM63 0 0 0 214 1 1
USP12 EIF3F 0 0 170 237 1 1
USP12 WDR55 0 0 0 232 1 1
USP12 MRE11A 0 0 0 159 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004843 Molecular Function cysteine-type deubiquitinase activity enables IBA
GO:0004843 Molecular Function cysteine-type deubiquitinase activity enables IDA
GO:0004843 Molecular Function cysteine-type deubiquitinase activity enables TAS
GO:0004197 Molecular Function cysteine-type endopeptidase activity enables IMP
GO:0046872 Molecular Function metal ion binding enables IEA
GO:0005515 Molecular Function protein binding enables IPI
GO:0016579 Biological Process protein deubiquitination involved_in IBA
GO:0016579 Biological Process protein deubiquitination involved_in IDA
GO:0005575 Cellular Component cellular_component is_active_in ND
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol is_active_in IBA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IDA
Pathways
Name DB ID
Metabolism of proteins Reactome R-HSA-392499
Deubiquitination Reactome R-HSA-5688426
Ub-specific processing proteases Reactome R-HSA-5689880
Post-translational protein modification Reactome R-HSA-597592
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_005266282 3 mRNA transcript variant X1 NC_000013 Reference
NM_182488 4 mRNA None NC_000013 Reference